fluorouracil has been researched along with folic acid in 199 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 43 (21.61) | 18.7374 |
| 1990's | 39 (19.60) | 18.2507 |
| 2000's | 39 (19.60) | 29.6817 |
| 2010's | 60 (30.15) | 24.3611 |
| 2020's | 18 (9.05) | 2.80 |
| Authors | Studies |
|---|---|
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Bertino, JR | 1 |
| Hutchison, DJ; Mehta, BM | 1 |
| Carmel, R | 1 |
| Hoffbrand, AV; Hooton, JW | 2 |
| Bruckner, HW; Schreiber, C; Waxman, S | 1 |
| Aceto, L; Gaspari, AL; Masi, G; Natoli, C; Rapani, C; Sica, G; Tinari, N; Trulli, R; Visini, R; Zakaria, M | 1 |
| Seitz, DE | 1 |
| Miyachi, H; Ohnuma, T; Sekiguchi, S; Takemura, Y | 1 |
| Allegra, CJ; Boarman, D; Chu, E; Zinn, S | 1 |
| Czejka, MJ; Fogl, U; Jäger, W; Schernthaner, G; Schüller, J | 1 |
| Adkins, DA; Houghton, JA; Houghton, PJ; Rahman, A | 1 |
| Cravo, ML; Mason, JB; Rosenberg, IH; Selhub, J | 1 |
| Arai, K; Awane, Y; Kitamura, M; Miyashita, K | 1 |
| Bertino, JR; Carotti, S; Coronnello, M; Gerli, A; Mazzei, T; Mini, E; Moroson, BA; Periti, P; Pesciullesi, A | 1 |
| Abdolrahim zadeh, S; Aronne, T; Codacci-Pisanelli, G; Franchi, F; Seminara, P | 1 |
| Archili, C; Barni, S; Crispino, S; Lissoni, P; Paolorossi, F; Tancini, G | 1 |
| Carenza, L; Giovagnoli, MR; Prosperi Porta, R; Rulli, G | 1 |
| Armenio, S; Francini, G; Gennari, C; Lorenzini, L | 1 |
| Kane, MA; Raptis, G; Roth, E; Schreiber, C; Waxman, S | 1 |
| Arbuck, SG; Creaven, PJ; Herrera, L; Mittelman, A; Petrelli, N; Rustum, YM; Trave, F; Zakrzewski, SF | 1 |
| Danenberg, KD; Danenberg, PV | 1 |
| Alison, DL; Calvert, AH; Harrap, KR; Jackman, AL | 1 |
| Keyomarsi, K; Moran, RG | 1 |
| Abels, J; Ermens, AA; Lindemans, J | 1 |
| Cantwell, BM; Harris, AL | 1 |
| deGraaf, SS; Houghton, JA; Houghton, PJ; Radparvar, S; Rodman, JR; Wainer, IW; Williams, LG | 1 |
| Ratner, LH | 1 |
| Hartenstein, RC; Rohloff, R; Trott, KR; Wendt, TG; Wustrow, TP | 1 |
| Lu, Y; Newman, EM; Priest, DG; Scanlon, KJ | 1 |
| Allegra, CJ; Bagley, C; Chabner, BA; Drake, JC; Lippman, ME; Sholar, PW | 1 |
| Asbury, RF; Bennett, J; Boros, L; Brower, M; Chang, A; Woll, J | 1 |
| Xu, B | 1 |
| Ambaye, RY; Ganu, UK; Gokhale, SV | 1 |
| Leibenguth, F | 1 |
| Reich, J; Soska, J | 1 |
| Spector, RG | 1 |
| Carlisle, H; Spector, RG | 1 |
| Joseph, LB; Simon, GT; Singh, AD; Singh, SP; Von Essen, CF | 1 |
| Herbert, V; Waxman, S | 1 |
| Bjerregaard, MR; Hutchison, DJ; Ittensohn, OL | 1 |
| Bertino, JR; Fernandes, DJ | 1 |
| Bertino, JR; Fernandes, DJ; Moroson, BA | 1 |
| Hakala, MT; Yin, MB; Zakrzewski, SF | 1 |
| Ambaye, RY; Gokhale, SV; Parchure, M | 1 |
| Bertino, JR; Fernandes, DJ; Mini, E | 1 |
| Bruckner, H; Waxman, S | 1 |
| Wickramasinghe, SN | 1 |
| Okabe, H; Takeda, S; Toko, T; Unemi, N; Yuasa, C | 1 |
| Healy, JB | 1 |
| Grygiel, JJ; Mainwaring, P | 1 |
| Brennan, J; Hageboutros, A; Hudes, GR; LaCreta, FP; McAleer, C; Newman, EM; O'Dwyer, PJ; Ozols, RF; Rogatko, A | 1 |
| Allegra, CJ | 1 |
| Mezger, J | 1 |
| Bastian, G; Brienza, S; Comisso, M; Etienne, MC; Lévi, F; Massari, C; Metzger, G; Milano, G; Misset, JL; Touitou, Y | 1 |
| Maxwell, RJ | 1 |
| Erlichman, C; Mitrovski, B | 1 |
| Bertrand, R; Jolivet, J | 1 |
| Goldschmidt, E; Grison, X; Guillot, T; Hannoun, L; Lotz, JP; Machover, D; Marquet, J; Metzger, G; Richaud, J; Zittoun, J | 1 |
| Bunni, MA; Priest, DG; Schmitz, JC | 1 |
| Dohden, K; Ohmura, K; Watanabe, Y | 1 |
| Fukushima, M; Ohshimo, H; Saito, H; Shimamoto, Y; Shirasaka, T | 1 |
| Bovo, G; Bratina, G; Brenna, A; Brivio, F; Brivio, O; Fumagalli, L; Lavorato, F; Perego, P; Uggeri, F | 1 |
| Carlsson, G; Gustavsson, BG; Jaresko, G; Muggia, FM; Spears, CP | 1 |
| Allegra, CJ; Drake, J; Geoffrey, F; Grem, JL; Johnston, PG; Voeller, D | 1 |
| Chéradame, S; Dassonville, O; Demard, F; Etienne, MC; Formento, P; Milano, G; Schneider, M | 1 |
| Goepel, M; Krege, S; Otto, B; Otto, T; Rübben, H | 1 |
| Chazal, M; Chéradame, S; Etienne, MC; Fischel, JL; Formento, P; Guillot, T; Milano, G | 1 |
| Brienza, S; Cvitkovic, E; Raymond, E; Soulié, P | 1 |
| Allegra, CJ; Chabner, BA; Chu, E; Fidias, P; Grem, JL; Grossbard, ML; Johnston, PG; Takimoto, CH | 1 |
| Branda, RF; Hacker, M; Lafayette, AR; Nigels, E | 1 |
| Geisler, J; Geisler, SB; Lønning, PE; Refsum, H; Smaaland, R; Tveit, KM; Ueland, PM | 1 |
| Priest, DG; Raghunathan, K | 1 |
| Amirault, P; Bonnans, H; Gauzan, MF; Lokiec, F; Santoni, J; Sauvage, N | 1 |
| Beger, HG; Butzer, U; Danenberg, KD; Danenberg, PV; Kornmann, M; Leder, G; Link, KH; Pillasch, J; Salonga, D; Sunelaitis, E | 1 |
| Backus, HH; Jansen, G; Molders, N; Padrón, JM; Peters, GJ; Pinedo, HM; van Der Wilt, CL; van Groeningen, CJ; Wouters, D | 1 |
| Araki, H; Fukushima, M; Kamiyama, Y; Shirasaka, T | 1 |
| Backus, HH; Bunni, MA; Comijn, L; Jackman, AL; Jansen, G; Mitchell, F; Peters, GJ; Priest, DG; Smid, K; van der Wilt, CL; Veerman, G; Voorn, DA; Wouters, D | 1 |
| Gmeiner, WH; Kolar, C; Lawson, TA; Liu, J | 1 |
| Adler, G; Lutz, MP | 1 |
| Inoue, H; Kim, R; Tanabe, K; Toge, T | 1 |
| Branda, RF; Brooks, EM; Chen, Z; Naud, SJ; Nicklas, JA | 1 |
| Höffken, K; Kliche, KO; Kubsch, K; Masri-Zada, R; Raida, M | 1 |
| Berger, FG; Bunni, MA; Davis, C; Kitchens, ME; Priest, DG; Spencer, HT; Tucker, JM | 1 |
| Branda, RF; Brooks, EM; Chen, Z; McCormack, JJ; Naud, SJ; Trainer, TD | 1 |
| Kornek, GV; Locker, GJ; Mader, RM; Pluschnig, U; Scheithauer, W; Steger, GG; Wenzel, C | 1 |
| Aschelter, AM; Bria, E; Cristaudo, A; Garufi, C; Santucci, B; Terzoli, E; Vanni, B | 1 |
| Büchler, MW; Dunn, JA; Friess, H; Ghaneh, P; Hickey, H; Neoptolemos, JP; Raraty, MG; Stocken, DD | 1 |
| Büchler, MW; Fischer, L; Friess, H; Uhl, W; Z'graggen, K | 1 |
| König, HH; Leidl, R; Link, KH; Monz, BU; Staib, L | 1 |
| Clippe, C; Freyer, G; Milano, G; Trillet-Lenoir, V | 1 |
| Chen, GL; Epner, DE; Kwabi-Addo, B; Lu, S; Ren, C | 1 |
| ANSFIELD, FJ | 1 |
| BIEDLER, JL; GREENBERG, NH; HUTCHISON, DJ; ROBINSON, DL; SCHRECKER, AW; VENDITTI, JM | 1 |
| LITTMAN, ML; MIWATANI, T | 1 |
| ANDERSON, EP; BROCKMAN, RW | 1 |
| CHAUVERGNE, J; HUGUES, A; LACHAPELE, AP; LAGARDE, C | 1 |
| CAVANAGH, D; FERGUSON, JH; MARTIN, DS | 1 |
| Curley, SA; Ellis, LM; Gentner, B; Parikh, AA; Vauthey, JN; Wu, TT | 1 |
| Baba, E; Fujishima, H; Harada, M; Kikuchi, I; Mitsugi, K; Miyanaga, O; Nakano, S; Ueda, A | 1 |
| Ajani, JA; Cohen, DS; Feig, B; Gunderson, LL; Janjan, N; Lynch, PM; Mansfield, PF; Morris, J; Myerson, R; Nivers, R; Pisters, PW | 1 |
| Alfieri, S; Cellini, N; De Paoli, A; Di Miceli, D; Doglietto, GB; Gambacorta, MA; Mantini, G; Miccichè, F; Morganti, AG; Ratto, C; Rossi, C; Rotondi, F; Valentini, V; Vargas, JG | 1 |
| Danenberg, PV | 1 |
| Medinger, M; Mross, K; Steinbild, S | 1 |
| Aparicio, J; Calderero, V; Díaz, R; Guerrero, A; Pellín, L; Segura, A | 1 |
| Boynton, A; Robien, K; Ulrich, CM | 1 |
| Casali, A; Gallo Curcio, C; Gionfra, T; Modugno, G; Paoletti, G; Tonachella, R; Tropea, F; Verri, C | 1 |
| Beale, P; Clarke, SJ; Horvath, L; Ong, S; Rivory, L; Sharma, R | 1 |
| Assenat, E; Duffour, J; Ychou, M | 1 |
| Iacopetta, B | 1 |
| Büchler, MW; Hoffmann, K; Jäger, D; Märten, A; Schmidt, J | 1 |
| Gupta, Y; Jain, A; Jain, P; Jain, SK | 1 |
| Caca, K; Feisthammel, J; Mössner, J; Schoppmeyer, K; Schulze, M; Wiedmann, M | 1 |
| Alvarez-Cabellos, R; Garcia-Carbonero, R; Garcia-Lacalle, C; Gomez, P; Paz-Ares, L; Sanchez, D; Tercero, A | 1 |
| Arnheim, KE | 1 |
| Asthana, A; Gupta, U; Jain, NK; Singh, P | 1 |
| Kim, YI | 1 |
| Fukuda, T; Shiroiwa, T; Tsutani, K | 1 |
| Lang, M; Li, J; Li, L; Shen, X; Tang, X; Zhang, Y | 1 |
| Fukushima, M; Kiniwa, M; Nakagawa, F; Saito, H; Sakamoto, E; Tsujimoto, H; Tsukioka, S; Uchida, J | 1 |
| Jennings, BA; Kwok, CS; Loke, YK; Matthews, V; Wawruch, P; Willis, G | 1 |
| Cai, Z; Chen, Y; Sun, B; Sun, Y; Yu, F; Zhang, H | 1 |
| Bao, L; Hao, Q; Liu, W; Wang, K; Zhang, L | 1 |
| Mathews, CK | 1 |
| Mohapatra, S; Sahu, S | 1 |
| Chang, GC; Chiu, LY; Hsu, SL; Huang, YR; Sheu, GT; Yang, TY | 1 |
| Cho, RC; Cole, PD; Croxford, R; Ishiguro, L; Kamen, BA; Kim, SE; Kim, YI; Ly, A; Sohn, KJ | 1 |
| Cho, YK; Chong, SY; Hong, SP; Hwang, SG; Jang, MJ; Jeon, YJ; Ji, YG; Kim, JW; Kim, NK; Oh, D | 1 |
| Arima, H; Hattori, K; Higashi, T; Koshigoe, T; Motoyama, K; Okamatsu, A; Onodera, R; Shimada, Y; Takeuchi, T | 1 |
| Besznyák, I; Bursics, A; Dede, K; Fekete, A; Kőszegi, G; Láng, I; Mersich, T; Mester, G; Pörneczi, B | 1 |
| Chen, L; Gao, W; Kong, LX; Li, P; Wang, Y; Zeng, F | 1 |
| Peng, X; Wei, K; Zou, F | 1 |
| Gao, QH; He, YX; Li, HL; Wu, GZ | 1 |
| Balasubramanian, S; Girija, AR; Iwai, S; Kizhikkilot, V; Maekawa, T; Nagaoka, Y; Nair, SD; Suzuki, M; Yoshida, Y | 1 |
| Azoulay, D; Calderaro, J; Zafrani, ES | 1 |
| Jennings, BA; Willis, G | 1 |
| Chen, DP; Li, MY; Liang, YY; Liu, JQ; Qi, B; Yin, WJ | 1 |
| Altug-Teber, Ö; Benedetti, JK; Blanke, CD; Holmes, RS; Lenz, HJ; Makar, KW; Rankin, C; Smalley, SR; Toriola, AT; Ulrich, CM | 1 |
| Lang, MD; Le, VM; Liu, JW; Nguyen, TL; Shi, WB; Wang, JJ; Xu, LM; Yin, GF; Yuan, M; Zheng, YH | 1 |
| Baigude, H; Gao, X; Hai, X; Li, Z; Shen, B; Su, H; Tan, Z; Yu, S; Zhang, R | 1 |
| Carlsson, G; Gustavsson, B; Odin, E; Sondén, A; Wettergren, Y | 2 |
| Boonsiri, P; Daduang, J; Daduang, S; Limpaiboon, T; Ngernyuang, N; Seubwai, W | 1 |
| Costache, M; Galateanu, B; Ginghina, O; Hayes, AW; Hudita, A; Ion, RM; Negrei, C; Nikitovic, D; Spandidos, DA; Stan, M; Tsatsakis, AM | 1 |
| Croxford, R; Grin, A; Ishiguro, L; Kim, YI; Sohn, KJ; Streutker, CJ; Yang, M | 1 |
| Abdullah, J; Abu, N; Alitheen, NB; Bwatanglang, IB; Hussein, MZ; Mohammad, F; Mohammed, NE; Nordin, N; Yeap, SK; Yusof, NA; Zamberi, NR | 1 |
| Ho, C; Jonker, D; Rayson, D; Stitt, L; Tokmakejian, S; Tomiak, A; Vincent, MD; Winquist, E; Yan, M | 1 |
| Danenberg, PV; Gustavsson, B; Johnston, P; Lindberg, P; Moser, R; Odin, E; Peters, GJ; Petrelli, N | 1 |
| Arias, JL; Delgado, ÁV; El-Hammadi, MM; Melguizo, C; Prados, JC | 1 |
| Baigude, H; Gao, X; Guan, W; Hai, X; Liu, Z | 1 |
| Asai, A; Doki, Y; Ishii, H; Kawamoto, K; Konno, M; Mori, M; Nishida, N; Satoh, T | 1 |
| Nordlund, JJ | 1 |
| Mohammadnejad, J; Narmani, A; Yavari, K | 1 |
| Antoniraj, MG; Ayyavu, M; Henry, LJK; Kandasamy, R; Nageshwar Rao, G; Natesan, S; Sundar, DS | 1 |
| Liu, J; Ren, F; Shen, M; Yang, B | 1 |
| A, S; Ayyavu, M; Kandasamy, R; M, GA; S, AT | 1 |
| Abdulla, A; Bagust, A; Beale, S; Boland, A; Fleeman, N; Kotas, E; McEntee, J; Palmer, D; Richardson, M; Stainthorpe, A | 1 |
| Amini, M; Angali, KA; Dorkoosh, FA; Handali, S; Kouchak, M; Moghimipour, E; Ramezani, Z; Rezaei, M | 1 |
| Al-Ramadhani, H; Al-Yacoub, S; Kadi, T; Tantawi, DA; Yousef, AM; Zawiah, M | 1 |
| Nawaz, A; Wong, TW | 1 |
| Boucheix, C; Dairou, J; Desterke, C; Gaston-Mathé, Y; Goldschmidt, E; Haghighi-Rad, F; Machover, D; Mollicone, R; Saffroy, R | 1 |
| de Moreno de LeBlanc, A; LeBlanc, JG; Levit, R; Savoy de Giori, G | 2 |
| Kim, K; Kim, S; Mani, G | 1 |
| Dong, H; Feng, YJ; Meng, XB; Sheng, JL; Sun, XJ; Yang, GX; Zhang, FM; Zhang, X | 1 |
| Ajaj, AR; Al-Hiary, R; Al-Yacoub, S; Kadi, T; Majdalawi, K; Mukred, R; Tantawi, D; Yousef, AM; Yousef, M; Zawiah, M | 1 |
| Decker, T; Denzlinger, C; Fischer von Weikersthal, L; Freiberg-Richter, J; Giessen-Jung, C; Graeven, U; Heinemann, V; Held, S; Jung, A; Kirchner, T; Modest, DP; Peuser, B; Peveling Genannt Reddemann, C; Schenk, M; Schuch, G; Schwaner, I; Stahler, A; Stintzing, S; Uhlig, J; Vehling-Kaiser, U | 1 |
| Amanlou, M; Bigdeli, B; Dehghani, S; Goliaei, B; Hosseini, M; Khoobi, M; Lotfabadi, A; Naeimi, H; Nejadshafiee, V; Nezamtaheri, MS; Sadighi, A; Sharifzadeh, M | 1 |
| Christy-Bittel, J; Ciardiello, F; Cuyle, PJ; Desai, J; Elez, E; Fakih, M; Gollerkeri, A; Grothey, A; Huijberts, S; Kopetz, S; Maharry, K; Montagut, C; Peeters, M; Sandor, V; Schellens, JHM; Tabernero, J; Van Cutsem, E; Wasan, H; Yaeger, R; Yoshino, T | 1 |
| Chen, HY; Hu, SW; Li, XL; Wang, J; Xu, JJ; Zhang, TT | 1 |
| Amini, M; Angali, KA; Dorkoosh, FA; Handali, S; Kouchak, M; Moghimipour, E; Ramezani, Z; Rezaei, M; Saremy, S | 1 |
| Dajani, O; Glimelius, B; Guren, TK; Hamfjord, J; Johansen, JS; Kure, EH; Lingjærde, OC; Pallisgaard, N; Pfeiffer, P; Sorbye, H; Spindler, KG; Tveit, KM | 1 |
| Abe, K; Eguchi, S; Fukui, S; Inoue, Y; Ito, S; Kanetaka, K; Kobayashi, K; Kosaka, T; Kuba, S; Morita, M; Sakimura, C; Takatsuki, M; Yamanouchi, K | 1 |
| Iimura, Y; Kanemoto, Y; Kuroda, S; Kurokawa, T; Nojima, M; Tsurita, G; Yazawa, K | 1 |
| Cui, R; Gao, X; Liu, Z; Song, L | 1 |
| Abazari, R; Ataei, F; L Carpenter-Warren, C; Morsali, A; Slawin, AMZ | 1 |
| Cui, X; Du, YE; Hou, Y; Liu, M; Liu, S; Peng, M; Qiao, Y; Qin, Y; Teng, Y; Wan, X; Yang, L; Zeng, H; Zhao, M | 1 |
| Kumar, P; Musalli, AH; Roy, P; Talukdar, PD; Wong, TW | 1 |
| Dusane, AC; Indukuri, VV; Janardhanam, LSL; Venuganti, VVK; Verma, P | 1 |
| He, DX; Huang, C; Huang, W; Liu, Y; Long, J; Tan, XW; Tang, S; Wei, H; Xiang, Y; Yu, CY; Zhou, Y | 1 |
| Musa, N; Wong, TW | 1 |
| de Gramont, A; Glimelius, B; Marshall, J; Stintzing, S; Yoshino, T | 1 |
| Abdul Qadir, M; Ahmad, S; Ahmed, M; Alharthy, RD; Hameed, A; Mirza, MU; Sarwar, S; Vanmeert, M | 1 |
| Ali, A; Basit, A; Jan, N; Khan, MM; Khan, S; Madni, A; Rai, N; Shafiq, A; Shah, H | 1 |
| Deng, F; Deng, W; Engel, A; Goldys, E; Sang, R | 1 |
| Dae-Hee, L; Ge, Y; Kou, F; Kwon, MH; Lee, DJ; Ma, N; Palanisamy, S; Shin, IS; You, S; Zhang, Y | 1 |
| Car, H; Lazny, R; Markiewicz, KH; Milewska, S; Misztalewska-Turkowicz, I; Niemirowicz-Laskowska, K; Sawicka, D; Siemiaszko, G; Szymczuk, D; Wilczewska, AZ | 1 |
| Mahdieh, A; Nyström, B; Sande, SA; Yeganeh, H | 1 |
| Ardakani, MT; Baneshi, M; Bardania, H; Barmak, MJ; Jafari, F; Mahmoudi, R; Safari, F | 1 |
| Cui, K; Fei, B; Huang, Z; Li, C; Ling, F; Sun, S; Teng, P; Yao, S | 1 |
| Bonvin, AM; Gahtory, D; Javed, A; Klumperman, J; Koukos, PI; Maas, PE; Maurice, MM; Mol, JA; Schwarz, LL; Shukla, R; Strous, GJ; Timmermans-Sprang, EP; van den Nieuwboer, M; van der Krift, F; van der Stelt, M; Veldhuizen, EJ; Vermeulen, M; Weingarth, M; Zijlmans, DW | 1 |
28 review(s) available for fluorouracil and folic acid
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[Totally implantable systems for long-term chemotherapeutic treatment].
Topics: Antineoplastic Combined Chemotherapy Protocols; Evaluation Studies as Topic; Fluorouracil; Folic Acid; Humans; Infusion Pumps, Implantable; Neoplasms; Time Factors | 1992 |
Biochemical modulation of fluoropyrimidines by antifolates and folates in an in vitro model of human leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Floxuridine; Fluorouracil; Folic Acid; Folic Acid Antagonists; Humans; Leukemia, Experimental | 1990 |
[New trends in antineoplastic drug research].
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Carboplatin; Danazol; Fluorouracil; Folic Acid; Harringtonines; Humans; Organoplatinum Compounds; Quinazolines; Thymine Nucleotides | 1985 |
The deoxyuridine suppression test: a review of its clinical and research applications.
Topics: Alcoholism; Anemia, Hemolytic; Anticonvulsants; Bone Marrow Cells; Bone Marrow Diseases; Cells; Deoxyuridine; Erythrocytes, Abnormal; Female; Fluorouracil; Folic Acid; Folic Acid Deficiency; Formyltetrahydrofolates; Homocysteine; Humans; Hypothyroidism; Lymphocyte Activation; Methionine; Pregnancy; Pregnancy Complications; Statistics as Topic; Tetrahydrofolates; Vitamin B 12; Vitamin B 12 Deficiency | 1981 |
[Adjuvant therapy in colorectal carcinomas].
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Fluorouracil; Folic Acid; Humans; Levamisole; Prospective Studies; Radiotherapy, Adjuvant; Rectal Neoplasms; Semustine; Vincristine | 1994 |
New techniques in the pharmacokinetic analysis of cancer drugs. III. Nuclear magnetic resonance.
Topics: Antineoplastic Agents; Fluorouracil; Folic Acid; Humans; Magnetic Resonance Spectroscopy; Misonidazole; Neoplasms | 1993 |
Cellular interactions between the natural and unnatural isomers of 5-formyltetrahydrofolate.
Topics: Animals; Cell Division; Cell Survival; Fluorouracil; Folic Acid; Humans; Leucovorin; Methotrexate; Stereoisomerism; Tumor Cells, Cultured | 1993 |
Folate metabolites as modulators of antitumor drug activity.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biological Transport; Biotransformation; Cell Line; Colorectal Neoplasms; Female; Fluorouracil; Folic Acid; Humans; Leucovorin; Ovarian Neoplasms; Tetrahydrofolates; Tumor Cells, Cultured | 1993 |
Aspects of one-carbon folate cycling related to fluoropyrimidine and antifolate therapy.
Topics: Animals; Antimetabolites, Antineoplastic; Fluorodeoxyuridylate; Fluorouracil; Folic Acid; Folic Acid Antagonists; Glycine Hydroxymethyltransferase; Humans; Leucovorin; Neoplasms | 1995 |
[Oxaliplatin: the first DACH platinum in clinical practice].
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Female; Fluorouracil; Folic Acid; Humans; Male; Neoplasms; Organoplatinum Compounds; Ovarian Neoplasms; Oxaliplatin; Peripheral Nervous System Diseases; Survival Analysis | 1997 |
Antimetabolites.
Topics: Animals; Antimetabolites, Antineoplastic; Cytarabine; DNA; Drug Resistance, Neoplasm; Fluorouracil; Folic Acid; Humans; Methotrexate | 1997 |
[Chemotherapy of colorectal carcinoma].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma; Chemotherapy, Adjuvant; Clinical Trials as Topic; Colorectal Neoplasms; Drug Administration Schedule; Fluorouracil; Folic Acid; Humans; Irinotecan; Neoadjuvant Therapy; Organoplatinum Compounds; Oxaliplatin; Palliative Care; Survival Analysis; Treatment Outcome | 2001 |
[Adjuvant and additive therapy for cancer of the pancreas].
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Chemotherapy, Adjuvant; Clinical Trials as Topic; Clinical Trials, Phase III as Topic; Combined Modality Therapy; Controlled Clinical Trials as Topic; Deoxycytidine; Doxorubicin; Female; Fluorouracil; Folic Acid; Gemcitabine; Hematinics; Humans; Leucovorin; Male; Mitoxantrone; Multicenter Studies as Topic; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Pancreatic Neoplasms; Quality of Life; Radiotherapy Dosage; Randomized Controlled Trials as Topic; Retrospective Studies; Surveys and Questionnaires; Time Factors | 2003 |
BIOCHEMISTRY OF CANCER (METABOLIC ASPECTS).
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Azaguanine; Azaserine; Carcinoma, Ehrlich Tumor; DNA; DNA, Neoplasm; Floxuridine; Fluorouracil; Folic Acid; Glutamine; Leukemia L1210; Mercaptopurine; Methotrexate; Mitomycin; Neoplasms; Neoplasms, Experimental; Pharmacology; Purines; Puromycin; Pyrimidines; Research; RNA; RNA, Neoplasm; Thioguanine; Thiouracil | 1963 |
Pharmacogenomics of thymidylate synthase in cancer treatment.
Topics: Animals; Antineoplastic Agents; Fluorouracil; Folic Acid; Gene Expression Regulation, Neoplastic; Humans; Loss of Heterozygosity; Neoplasms; Pharmacogenetics; Polymerase Chain Reaction; Polymorphism, Genetic; Promoter Regions, Genetic; Thymidylate Synthase; Treatment Outcome | 2004 |
[Adjuvant and palliative anticancer treatment of colon carcinoma in 2004].
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Cetuximab; Chemotherapy, Adjuvant; Clinical Trials, Phase III as Topic; Colon; Colonic Neoplasms; Colorectal Neoplasms; Combined Modality Therapy; Fluorouracil; Folic Acid; Humans; Leucovorin; Neoplasm Recurrence, Local; Neoplasm Staging; Organoplatinum Compounds; Palliative Care; Postoperative Care; Randomized Controlled Trials as Topic; Time Factors | 2004 |
Pharmacogenetics of folate-related drug targets in cancer treatment.
Topics: Animals; Antineoplastic Agents; Fluorouracil; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Models, Biological; Neoplasms; Pharmacogenetics; Polymorphism, Genetic; Thymidylate Synthase | 2005 |
[Irinotecan for the treatment of metastatic colorectal cancer].
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Folic Acid; Humans; Irinotecan; Maximum Tolerated Dose; Multicenter Studies as Topic; Pharmacogenetics | 2006 |
Methyl-group metabolism and the response of colorectal cancer to 5-fluorouracil.
Topics: Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); DNA Methylation; Fluorouracil; Folic Acid; Humans; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Microsatellite Repeats; Thymidylate Synthase | 2006 |
Role of the MTHFR polymorphisms in cancer risk modification and treatment.
Topics: Antineoplastic Agents; Drug Resistance, Neoplasm; Fluorouracil; Folic Acid; Genetic Predisposition to Disease; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Neoplasms; Polymorphism, Single Nucleotide; Risk Factors | 2009 |
Functional polymorphisms of folate metabolism and response to chemotherapy for colorectal cancer, a systematic review and meta-analysis.
Topics: Capecitabine; Colorectal Neoplasms; Databases, Genetic; Deoxycytidine; Fluorouracil; Folic Acid; Gene Expression Regulation, Neoplastic; Genetic Association Studies; Genetic Variation; Genotype; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 2012 |
How folate metabolism affects colorectal cancer development and treatment; a story of heterogeneity and pleiotropy.
Topics: Capecitabine; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Genetic Heterogeneity; Genetic Pleiotropy; Genetic Variation; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Thymidylate Synthase | 2015 |
Folates as adjuvants to anticancer agents: Chemical rationale and mechanism of action.
Topics: Antineoplastic Combined Chemotherapy Protocols; Fluorouracil; Folic Acid; Humans; Neoplasms | 2016 |
The one-carbon metabolism pathway highlights therapeutic targets for gastrointestinal cancer (Review).
Topics: Aminohydrolases; Antineoplastic Agents; Fluorouracil; Folic Acid; Folic Acid Antagonists; Gastrointestinal Neoplasms; Glycine Hydroxymethyltransferase; Humans; Metabolic Networks and Pathways; Metabolome; Methionine; Methylenetetrahydrofolate Dehydrogenase (NADP); MicroRNAs; Mitochondria; Molecular Targeted Therapy; Multienzyme Complexes; Nucleosides; Nucleotides; Oxidoreductases Acting on CH-NH Group Donors; Purines; Reactive Oxygen Species; Serine | 2017 |
The Medical Treatment of Vitiligo: An Historical Review.
Topics: Administration, Cutaneous; Adrenal Cortex Hormones; Anthelmintics; Antimalarials; Antimetabolites, Antineoplastic; Calcineurin Inhibitors; Catalase; Clofazimine; Fluorouracil; Folic Acid; History, 16th Century; History, 17th Century; History, 18th Century; History, 19th Century; History, 20th Century; Humans; Khellin; Leprostatic Agents; Levamisole; Phenylalanine; PUVA Therapy; Vitiligo | 2017 |
Pegylated Liposomal Irinotecan Hydrochloride Trihydrate for Treating Pancreatic Cancer After Gemcitabine: An Evidence Review Group Perspective of a NICE Single Technology Appraisal.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cost-Benefit Analysis; Fluorouracil; Folic Acid; Humans; Irinotecan; Leucovorin; Pancreatic Neoplasms; Technology Assessment, Biomedical; Topoisomerase I Inhibitors | 2018 |
Metastatic colorectal cancer: Advances in the folate-fluoropyrimidine chemotherapy backbone.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colorectal Neoplasms; Fluorouracil; Folic Acid; Humans; Irinotecan; Leucovorin; Oxaliplatin; Prognosis | 2021 |
24 trial(s) available for fluorouracil and folic acid
| Article | Year |
|---|---|
Phase I study of phosphonacetyl-L-aspartate, 5-fluorouracil, and leucovorin in patients with advanced cancer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Diarrhea; Digestive System; Drug Synergism; Female; Fluorouracil; Folic Acid; Humans; Leucovorin; Male; Middle Aged; Neoplasms; Neutropenia; Phosphonoacetic Acid; Proportional Hazards Models; Pyrimidines; Remission Induction; Risk Factors; Thymidylate Synthase | 1995 |
[Adjuvant therapy in colorectal carcinomas].
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Fluorouracil; Folic Acid; Humans; Levamisole; Prospective Studies; Radiotherapy, Adjuvant; Rectal Neoplasms; Semustine; Vincristine | 1994 |
Spontaneous or imposed circadian changes in plasma concentrations of 5-fluorouracil coadministered with folinic acid and oxaliplatin: relationship with mucosal toxicity in patients with cancer.
Topics: Adult; Aged; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Circadian Rhythm; Colorectal Neoplasms; Female; Fluorouracil; Folic Acid; Humans; Infusion Pumps; Leucovorin; Male; Middle Aged; Mouth Mucosa; Organoplatinum Compounds; Oxaliplatin; Stereoisomerism; Stomatitis; Tetrahydrofolates | 1994 |
5-Fluorouracil combined with the pure [6S]-stereoisomer of folinic acid in high doses for treatment of patients with advanced colorectal carcinoma: a phase I-II study of two consecutive regimens.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Dose-Response Relationship, Drug; Fluorouracil; Folic Acid; Follow-Up Studies; Humans; Leucovorin; Middle Aged; Pyrimidines; Stereoisomerism | 1993 |
[Therapy with mitomycin C, folic acid and 5-fluorouracil in treatment of metastatic, refractory urinary bladder carcinoma--phase II study].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Transitional Cell; Drug Resistance, Neoplasm; Female; Fluorouracil; Folic Acid; Follow-Up Studies; Humans; Male; Middle Aged; Mitomycin; Neoplasm Metastasis; Prospective Studies; Survival Rate; Urinary Bladder Neoplasms | 1997 |
Changes in folate status as determined by reduction in total plasma homocysteine levels during leucovorin modulation of 5-fluorouracil therapy in cancer patients.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Colorectal Neoplasms; Creatinine; Erythrocytes; Female; Fluorouracil; Folic Acid; Homocysteine; Humans; Leucovorin; Male; Middle Aged; Vitamin B 12 | 1998 |
Thymidylate synthase quantitation and in vitro chemosensitivity testing predicts responses and survival of patients with isolated nonresectable liver tumors receiving hepatic arterial infusion chemotherapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Epirubicin; Female; Fluorouracil; Folic Acid; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Mitomycin; Mitoxantrone; Predictive Value of Tests; Prospective Studies; Thymidylate Synthase; Treatment Outcome; Tumor Stem Cell Assay | 2000 |
Chronomodulated chemotherapy in metastatic gastrointestinal cancer combining 5-FU and sodium folinate with oxaliplatin, irinotecan or gemcitabine: the Jena experience in 79 patients.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biliary Tract Neoplasms; Camptothecin; Colorectal Neoplasms; Deoxycytidine; Female; Fluorouracil; Folic Acid; Gastrointestinal Neoplasms; Gemcitabine; Humans; Irinotecan; Male; Middle Aged; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Pancreatic Neoplasms; Stomach Neoplasms | 2002 |
Capecitabine treatment results in increased mean corpuscular volume of red blood cells in patients with advanced solid malignancies.
Topics: Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Erythrocyte Indices; Erythrocytes; Female; Fluorouracil; Folic Acid; Hematinics; Homocysteine; Humans; Male; Middle Aged; Neoplasms; Prospective Studies; Retrospective Studies; Thymidylate Synthase; Vitamin B 12 | 2003 |
Skin testing and hypersensitivity reactions to oxaliplatin.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Hypersensitivity; Female; Fluorouracil; Folic Acid; Humans; Injections, Intradermal; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Predictive Value of Tests; Skin Tests | 2003 |
Cost effectiveness of adding folinic acid to fluorouracil plus levamisole as adjuvant chemotherapy in patients with colon cancer in Germany.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Cost-Benefit Analysis; Female; Fluorouracil; Folic Acid; Germany; Humans; Levamisole; Male; Middle Aged; National Health Programs; Quality-Adjusted Life Years | 2003 |
Phase I study of CPT-11 and bolus 5-FU/ l-leucovorin in patients with metastatic colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Female; Fluorouracil; Folic Acid; Humans; Infusions, Intravenous; Irinotecan; Leucovorin; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Metastasis; Treatment Outcome | 2004 |
Multi-institutional trial of preoperative chemoradiotherapy in patients with potentially resectable gastric carcinoma.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Female; Fluorouracil; Folic Acid; Gastrectomy; Humans; Leucovorin; Male; Middle Aged; Neoplasm Staging; Radiotherapy; Stomach Neoplasms; Survival Analysis; Treatment Outcome | 2004 |
Chemoradiation with raltitrexed (Tomudex) in preoperative treatment of stage II-III resectable rectal cancer: a phase II study.
Topics: Aged; Antimetabolites, Antineoplastic; Female; Fluorouracil; Folic Acid; Follow-Up Studies; Hematinics; Humans; Male; Middle Aged; Neoplasm Staging; Quinazolines; Radiotherapy, Conformal; Rectal Neoplasms; Thiophenes | 2004 |
A phase II study of fixed-dose capecitabine and assessment of predictors of toxicity in patients with advanced/metastatic colorectal cancer.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Diarrhea; Disease Progression; Fatigue; Female; Fluorouracil; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Neoplasm Metastasis; Predictive Value of Tests; Survival Analysis | 2006 |
Impact of interferon-alpha in combined chemoradioimmunotherapy for pancreatic adenocarcinoma (CapRI): first data from the immunomonitoring.
Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Cytokines; Fluorouracil; Folic Acid; Granzymes; Humans; Immunophenotyping; Interferon-alpha; Killer Cells, Natural; Leukocytes; Pancreatic Neoplasms; Prospective Studies | 2007 |
Irinotecan with 5-FU/FA in advanced biliary tract adenocarcinomas: a multicenter phase II trial.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Biliary Tract Neoplasms; Camptothecin; Female; Fluorouracil; Folic Acid; Humans; Irinotecan; Male; Middle Aged; Survival Analysis; Vitamin B Complex | 2007 |
Fluorouracil-based chemotherapy in patients with gastrointestinal malignancies: influence of nutritional folate status on toxicity.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Female; Fluorouracil; Folic Acid; Gastrointestinal Neoplasms; Homocysteine; Humans; Male; Middle Aged; Vitamin B 12 | 2007 |
Cost-effectiveness analysis of XELOX for metastatic colorectal cancer based on the NO16966 and NO16967 trials.
Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colorectal Neoplasms; Cost-Benefit Analysis; Deoxycytidine; Disease-Free Survival; Female; Fluorouracil; Folic Acid; Health Care Costs; Humans; Male; Middle Aged; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Quality of Life; Retrospective Studies; Treatment Outcome | 2009 |
Glycididazole sodium combined with radiochemotherapy for locally advanced nasopharyngeal carcinoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Case-Control Studies; Chemoradiotherapy; Cisplatin; Female; Fluorouracil; Folic Acid; Follow-Up Studies; Humans; Male; Metronidazole; Middle Aged; Nasopharyngeal Neoplasms; Neoplasm Staging; Prognosis; Survival Rate | 2014 |
Polymorphisms in folate-metabolizing enzymes and response to 5-fluorouracil among patients with stage II or III rectal cancer (INT-0144; SWOG 9304).
Topics: Adult; Aged; Aged, 80 and over; Disease-Free Survival; Female; Fluorouracil; Folic Acid; Genetic Association Studies; Genetic Predisposition to Disease; Glycine Hydroxymethyltransferase; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Pharmacogenetics; Polymorphism, Single Nucleotide; Rectal Neoplasms; Reduced Folate Carrier Protein; Thymidylate Synthase | 2014 |
Sequential Versus Combination Therapy of Metastatic Colorectal Cancer Using Fluoropyrimidines, Irinotecan, and Bevacizumab: A Randomized, Controlled Study-XELAVIRI (AIO KRK0110).
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colorectal Neoplasms; Deoxycytidine; Drug Administration Schedule; Female; Fluorouracil; Folic Acid; Humans; Irinotecan; Leucovorin; Male | 2019 |
Binimetinib, Encorafenib, and Cetuximab Triplet Therapy for Patients With
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Carbamates; Cetuximab; Colorectal Neoplasms; Female; Fluorouracil; Folic Acid; Humans; Irinotecan; Male; Middle Aged; Mutation; Progression-Free Survival; Proto-Oncogene Proteins B-raf; Sulfonamides; Survival Rate | 2019 |
Total circulating cell-free DNA as a prognostic biomarker in metastatic colorectal cancer before first-line oxaliplatin-based chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Cell-Free Nucleic Acids; Clinical Trials, Phase III as Topic; Colorectal Neoplasms; Female; Fluorouracil; Folic Acid; Follow-Up Studies; Humans; Liver Neoplasms; Lymphatic Metastasis; Male; Oxaliplatin; Prognosis; Prospective Studies; Retrospective Studies; Survival Rate | 2019 |
148 other study(ies) available for fluorouracil and folic acid
| Article | Year |
|---|---|
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Toward improved selectivity in cancer chemotherapy: the Richard and Hinda Rosenthal Foundation Award Lecture.
Topics: Animals; Antineoplastic Agents; Carboxypeptidases; Drug Resistance; Drug Therapy, Combination; Fluorouracil; Folic Acid; Folic Acid Antagonists; Humans; Leucovorin; Methotrexate; Neoplasms; Uracil Nucleotides | 1979 |
Microbiologic assays of cancer chemotherapeutic agents.
Topics: Antineoplastic Agents; Biological Assay; Cytarabine; Fluorouracil; Folic Acid; Lacticaseibacillus casei; Leucovorin; Mercaptopurine; Methotrexate; Pediococcus; Streptococcus; Tetrahydrofolates; Thioguanine | 1977 |
Effects of antineoplastic drugs on Lactobacillus casei and radioisotopic assays for serum folate.
Topics: Antineoplastic Agents; Biological Assay; Drug Interactions; Fluorouracil; Folic Acid; Humans; Lacticaseibacillus casei; Methotrexate; Radioisotopes | 1978 |
[3H]Thymidine triphosphate incorporation into isolated nuclei.
Topics: Anemia, Megaloblastic; Cell Nucleus; DNA Replication; Fluorouracil; Folic Acid; Humans; Hydroxyurea; Lectins; Lymphocyte Activation; Lymphocytes; Thymine Nucleotides; Vitamin B 12 | 1976 |
Thymidine kinase in megaloblastic anaemia.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Female; Fluorouracil; Folic Acid; Folic Acid Deficiency; Humans; Lectins; Lymphocyte Activation; Male; Methotrexate; Puromycin; Sonication; Thymidine Kinase; Vitamin B 12; Vitamin B 12 Deficiency | 1976 |
Interaction of chemotherapeutic agents with methotrexate and 5-fluorouracil and its effect on de novo DNA synthesis.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cephalosporins; Dexamethasone; DNA; DNA, Neoplasm; Fluorouracil; Folic Acid; Glucocorticoids; Humans; Hydrocortisone; Idoxuridine; In Vitro Techniques; Leukemia L1210; Methotrexate; Mice; Mice, Inbred DBA; Prednisolone; Prednisone; Vincristine | 1975 |
Oncology drug discovery and clinical trial testing: who's listening?
Topics: Antineoplastic Agents; Clinical Trials as Topic; Drug Evaluation; Fluorouracil; Folic Acid; Humans; Neoplasms; Quinazolines; Thymidylate Synthase | 1992 |
A human leukemia cell line made resistant to two folate analogues, trimetrexate and N10-propargyl-5,8-dideazafolic acid (CB3717).
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Division; Cell Line; Cisplatin; Cross Reactions; Dactinomycin; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Etoposide; Fluorouracil; Folic Acid; Humans; Leucovorin; Membrane Glycoproteins; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quinazolines; RNA, Messenger; Thymidylate Synthase; Trimetrexate; Vincristine | 1991 |
Interaction of gamma interferon and 5-fluorouracil in the H630 human colon carcinoma cell line.
Topics: Adenocarcinoma; Cell Division; Colonic Neoplasms; DNA; Drug Interactions; Drug Resistance; Fluorodeoxyuridylate; Fluorouracil; Folic Acid; Humans; Interferon-gamma; RNA; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Tumor Cells, Cultured | 1990 |
[Pharmacokinetic aspects of the combination of interferon-alpha-2b and folic acid with fluorouracil].
Topics: Aged; Biological Availability; Female; Fluorouracil; Folic Acid; Humans; Injections, Intravenous; Interferon alpha-2; Interferon-alpha; Male; Recombinant Proteins | 1991 |
Interaction between 5-fluorouracil, [6RS]leucovorin, and recombinant human interferon-alpha 2a in cultured colon adenocarcinoma cells.
Topics: Adenocarcinoma; Cell Survival; Colonic Neoplasms; Drug Synergism; Fluorouracil; Folic Acid; Interferon Type I; Leucovorin; Quinazolines; Recombinant Proteins; Thymidylate Synthase; Tumor Cells, Cultured | 1991 |
Use of the deoxyuridine suppression test to evaluate localized folate deficiency in rat colonic epithelium.
Topics: Animals; Cells, Cultured; Colon; Deoxyuridine; DNA; Epithelium; Fluorouracil; Folic Acid; Male; Rats; Rats, Inbred Strains; Thymidine | 1991 |
[Macrocytic anemia as a possible adverse effect of fluoropyrimidines].
Topics: Anemia, Macrocytic; Antineoplastic Combined Chemotherapy Protocols; Erythrocyte Indices; Female; Fluorouracil; Folic Acid; Humans; Male; Retrospective Studies; Stomach Neoplasms; Tegafur; Uracil; Vitamin B 12 | 1990 |
Discoloration of the nails and early anemia after mitoxantrone, folinic acid and 5-fluorouracil.
Topics: Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Folic Acid; Hemoglobins; Humans; Mitoxantrone; Nail Diseases; Pigmentation Disorders | 1990 |
A study of the pineal hormone melatonin as a second line therapy in metastatic colorectal cancer resistant to fluorouracil plus folates.
Topics: Adult; Aged; Antineoplastic Agents; Colorectal Neoplasms; Drug Resistance; Female; Fluorouracil; Folic Acid; Humans; Male; Melatonin; Middle Aged; Neoplasm Metastasis | 1990 |
Modulation of fluoropyrimidines by folates. Workshop on new frontiers in medical oncology. Erice, Italy, March 20-23, 1989. Proceedings.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Fluorouracil; Folic Acid; Humans; Neoplasms | 1990 |
Chemosensitivity and DNA content as prognostic factors in ovarian cancer: preliminary results.
Topics: Adenocarcinoma; Aged; Colony-Forming Units Assay; Doxorubicin; Female; Fluorouracil; Folic Acid; Humans; In Vitro Techniques; Middle Aged; Ovarian Neoplasms; Ploidies; Prognosis; Tumor Stem Cell Assay | 1990 |
Palliative chemotherapy for relief of subocclusive symptoms.
Topics: Abdominal Neoplasms; Drug Therapy, Combination; Fluorouracil; Folic Acid; Humans; Palliative Care; Pelvic Neoplasms | 1987 |
Effect of intracellular folate concentration on the modulation of 5-fluorouracil cytotoxicity by the elevation of phosphoribosylpyrophosphate in cultured human KB cells.
Topics: Adenosine; Carcinoma, Squamous Cell; Cell Survival; Fluorouracil; Folic Acid; Glucose; Humans; KB Cells; Leucovorin; Leukemia, Myeloid, Acute; Methotrexate; Nasopharyngeal Neoplasms; Pentosephosphates; Phosphoribosyl Pyrophosphate; Thymidine | 1987 |
Biochemical and pharmacologic basis for potentiation of 5-fluorouracil action by leucovorin.
Topics: Animals; Biotransformation; Cell Division; Colonic Neoplasms; DNA; Drug Synergism; Fluorouracil; Folic Acid; Humans; Leucovorin; Leukemia L1210; Mice; RNA; Stomach Neoplasms; Thymidine; Thymidylate Synthase | 1987 |
Activity of thymidylate synthetase and its inhibition by 5-fluorouracil in highly enzyme-overproducing cells resistant to 10-propargyl-5,8-dideazafolate.
Topics: Animals; Blotting, Southern; Drug Resistance; Floxuridine; Fluorouracil; Folic Acid; Gene Amplification; Mice; Quinazolines; Thymidylate Synthase; Tumor Cells, Cultured | 1989 |
Increased thymidylate synthase in L1210 cells possessing acquired resistance to N10-propargyl-5,8-dideazafolic acid (CB3717): development, characterization, and cross-resistance studies.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Deoxyuridine; Drug Resistance; Floxuridine; Fluorouracil; Folic Acid; Folic Acid Antagonists; Hypoxanthine; Hypoxanthines; Kinetics; Leukemia L1210; Mice; Quinazolines; Thymidylate Synthase; Tritium | 1986 |
Folinic acid augmentation of the effects of fluoropyrimidines on murine and human leukemic cells.
Topics: Animals; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Floxuridine; Fluorouracil; Folic Acid; Humans; Leucovorin; Leukemia; Leukemia L1210; Mice | 1986 |
Moderate antiproliferative effect of the antifolate CB3717 in the BN myeloid leukaemia model.
Topics: Animals; Antineoplastic Agents; Deoxyuridine; DNA; Fluorouracil; Folic Acid; Folic Acid Antagonists; Leukemia, Myeloid, Acute; Quinazolines; Rats; Thymidine Monophosphate; Thymidylate Synthase | 1988 |
The efficacy of 5-fluorouracil in human colorectal cancer is not enhanced by thymidylate synthetase inhibition with CB3717 (N10-propargyl-5,8 dideazafolic acid).
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Fluorouracil; Folic Acid; Humans; Middle Aged; Quinazolines; Rectal Neoplasms; Thymidylate Synthase | 1988 |
Selectivity of CF and 5-fluorouracil: critical role of polyglutamylation.
Topics: Adenocarcinoma; Animals; Cell Line; Colonic Neoplasms; Fluorouracil; Folic Acid; Humans; Leucovorin; Mice; Neoplasm Transplantation; Pteroylpolyglutamic Acids; Thymidylate Synthase; Transplantation, Heterologous | 1988 |
Folic acid instead of leucovorin for 5-FU modulation?
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Costs and Cost Analysis; Fluorouracil; Folic Acid; Humans; Leucovorin | 1988 |
Accelerated split-course radiotherapy and simultaneous cis-dichlorodiammine-platinum and 5-fluorouracil chemotherapy with folinic acid enhancement for unresectable carcinoma of the head and neck.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Cobalt Radioisotopes; Combined Modality Therapy; Female; Fluorouracil; Folic Acid; Follow-Up Studies; Gamma Rays; Head and Neck Neoplasms; Humans; Male; Middle Aged; Radiotherapy Planning, Computer-Assisted | 1987 |
Biochemical basis for cisplatin and 5-fluorouracil synergism in human ovarian carcinoma cells.
Topics: Carcinoma; Cell Line; Cisplatin; Drug Synergism; Female; Fluorodeoxyuridylate; Fluorouracil; Folic Acid; Humans; Ovarian Neoplasms; Tetrahydrofolates; Thymidine Monophosphate; Thymidylate Synthase | 1986 |
Preliminary results of a phase II trial for the treatment of metastatic breast cancer with 5-fluorouracil and leucovorin.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Evaluation; Fluorodeoxyuridylate; Fluorouracil; Folic Acid; Humans; Leucovorin; Middle Aged; Neoplasm Metastasis; Thymidylate Synthase | 1987 |
5-Fluorouracil and high-dose folic acid treatment for metastatic colon cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Diarrhea; Female; Fluorouracil; Folic Acid; Humans; Male; Middle Aged; Neoplasm Metastasis | 1987 |
Effects of anticancer drugs on folate disposition and excretion.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Fluorouracil; Folic Acid; Liver; Lung Neoplasms; Male; Methotrexate; Mice | 1985 |
[On tryptophan pyrrolase activity in the embryonic chick liver].
Topics: Animals; Chick Embryo; Enzyme Repression; Fluorouracil; Folic Acid; Liver; Stimulation, Chemical; Testosterone; Tryptophan Oxygenase | 1969 |
Thymineless death in Lactobacillus acidophilus R-26.
Topics: Adenine Nucleotides; Culture Media; Fluorouracil; Folic Acid; Lactobacillus acidophilus; Thymine | 1970 |
Influence of folic acid on noradrenaline stimulation of rat brain synaptosomes.
Topics: Animals; Brain; Epinephrine; Fluorouracil; Folic Acid; Folic Acid Antagonists; In Vitro Techniques; Nerve Endings; Norepinephrine; Oxygen Consumption; Phenobarbital; Rats; Synaptic Vesicles; Synaptosomes | 1971 |
The effect of anti-metabolites on leptazol induced fits in rats.
Topics: Animals; Antimetabolites; Azathioprine; Brain; Cytarabine; Daunorubicin; Fluorouracil; Folic Acid; Folic Acid Antagonists; Methotrexate; Pentylenetetrazole; Pyrimethamine; Rats; Seizures | 1971 |
Sequential chemotherapy and radiation therapy of buccal mucosa carcinoma in South India. Methods and preliminary results.
Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Cheek; Cobalt Isotopes; Deoxyuridine; Female; Fluorouracil; Folic Acid; Humans; India; Leukocyte Count; Male; Methotrexate; Middle Aged; Mouth Mucosa; Mouth Neoplasms; Radioisotope Teletherapy; Radiotherapy Dosage | 1968 |
Mechanism of pyrimethamine-induced megaloblastosis in human bone marrow.
Topics: Anemia, Macrocytic; Bone Marrow; Bone Marrow Diseases; Chorioretinitis; Culture Techniques; Deoxyuridine; DNA; Erythrocytes; Female; Fluorouracil; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Middle Aged; Nucleotides; Oxidation-Reduction; Pyrimethamine; Thymidine; Tritium | 1969 |
Growth of L1210 mouse leukemia cells in vitro.
Topics: Animals; Chromosomes; Culture Techniques; Fluorouracil; Folic Acid; Leukemia L1210; Mercaptopurine; Methotrexate; Mice; Microscopy | 1966 |
5-fluorouracil-methotrexate synergy: enhancement of 5-fluorodeoxyridylate binding to thymidylate synthase by dihydropteroylpolyglutamates.
Topics: Animals; Cell Survival; Drug Synergism; Floxuridine; Fluorouracil; Folic Acid; Leukemia L1210; Methotrexate; Methyltransferases; Polyglutamic Acid; Protein Binding; Pteroylpolyglutamic Acids; Thymidylate Synthase | 1980 |
The role of methotrexate and dihydrofolate polyglutamates in the enhancement of fluorouracil action by methotrexate.
Topics: Animals; Cell Line; Cell Survival; Drug Administration Schedule; Drug Therapy, Combination; Fluorodeoxyuridylate; Fluorouracil; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Polyglutamic Acid; Pteroylpolyglutamic Acids; Thymidylate Synthase | 1981 |
Relationship of cellular folate cofactor pools to the activity of 5-fluorouracil.
Topics: Animals; Carcinoma; Chromatography, Gel; Fibroblasts; Fluorouracil; Folic Acid; gamma-Glutamyl Hydrolase; Humans; Mice; Sarcoma 180; Species Specificity; Thymidylate Synthase | 1983 |
Combination of anticancer agents with folic acid in the treatment of murine leukaemia P388.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Drug Evaluation, Preclinical; Drug Synergism; Fluorouracil; Folic Acid; Leukemia P388; Leukemia, Experimental; Methotrexate; Mice; Mitomycins | 1984 |
Sequential methotrexate and 5-fluorouracil: mechanisms of synergy.
Topics: Animals; Biotransformation; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Fluorodeoxyuridylate; Fluorouracil; Folic Acid; Humans; Methotrexate; Mice; Neoplasm Transplantation; Sarcoma, Experimental; Thymidylate Synthase; Time Factors | 1983 |
The enhancement of 5-fluorouracil anti-metabolic activity by leucovorin, menadione and alpha-tocopherol.
Topics: Animals; Antimetabolites; Cell Count; Cell Division; Cell Line; Deoxyuridine; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Interactions; Fluorouracil; Folic Acid; Leucovorin; Leukemia, Erythroblastic, Acute; Mice; Vitamin E; Vitamin K | 1982 |
[Augmentation of chemotherapeutic efficaciousness of UFT by oral l-leucovorin--l-leucovorin factors enhancing cytotoxic activity of 5-fluorouracil].
Topics: Adenocarcinoma; Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Fluorouracil; Folic Acid; Humans; Leucovorin; Tegafur; Tumor Cells, Cultured; Uracil | 1995 |
Re: Enigma of fluorouracil and levamisole.
Topics: Antimetabolites, Antineoplastic; Fluorouracil; Folic Acid; Humans; Leucovorin; Levamisole; Neoplasms | 1995 |
Interaction of 5-fluorouracil with folates.
Topics: Aged; Colonic Neoplasms; Drug Interactions; Drug Therapy, Combination; Female; Fluorouracil; Folic Acid; Humans; Male; Middle Aged; Rectal Neoplasms | 1995 |
New therapeutic strategies for patients with gastrointestinal malignancies using biochemical modulation of fluorouracil.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Colonic Neoplasms; Fatal Outcome; Fluorouracil; Folic Acid; Folic Acid Antagonists; Gastrointestinal Neoplasms; Gene Expression Regulation, Enzymologic; Humans; Interferon-alpha; Leucovorin; Liver Neoplasms; Male; Middle Aged; Prognosis; Quinazolines; RNA, Messenger; RNA, Neoplasm; Thymidylate Synthase | 1995 |
Comparative cytotoxicity of folate-based inhibitors of thymidylate synthase and 5-fluorouracil +/- leucovorin in MGH-U1 cells.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Survival; Drug Screening Assays, Antitumor; Fluorouracil; Folic Acid; Glutamates; Humans; Indoles; Isoindoles; Leucovorin; Quinazolines; Thymidylate Synthase; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1994 |
Ternary complex formation and reduced folate in surgical specimens of human adenocarcinoma tissues.
Topics: Adenocarcinoma; Colorectal Neoplasms; Culture Techniques; Fluorouracil; Folic Acid; Humans; Leucovorin; Lymph Nodes; Phosphorylation; Stomach Neoplasms; Tetrahydrofolates; Thymidine Kinase; Thymidylate Synthase | 1993 |
Metabolic basis of the synergistic antitumor activities of 5-fluorouracil and cisplatin in rodent tumor models in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Ascites; Cisplatin; Drug Synergism; Fluorouracil; Folic Acid; Leukemia P388; Male; Mice; Mice, Inbred DBA; Neoplasm Transplantation; Neoplasms, Experimental; Oxidation-Reduction; Rats; Rats, Inbred Strains; Sarcoma, Yoshida; Tumor Cells, Cultured | 1993 |
Pre-operative interleukin-2 immunotherapy induces eosinophilic infiltration in colorectal neoplastic stroma.
Topics: Adult; Antineoplastic Agents; Carcinoma; Chemotaxis, Leukocyte; Chemotherapy, Adjuvant; Colorectal Neoplasms; Combined Modality Therapy; Connective Tissue; Eosinophilia; Eosinophils; Female; Fluorouracil; Folic Acid; Humans; Immunologic Factors; Immunotherapy; Interleukin-2; Leukocyte Count; Male; Middle Aged; Neoplasm Recurrence, Local; Palliative Care; Premedication; Prognosis; Recombinant Proteins; Treatment Outcome | 1995 |
The cellular interaction of 5-fluorouracil and cisplatin in a human colon carcinoma cell line.
Topics: Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Cell Division; Cisplatin; Colonic Neoplasms; DNA Damage; DNA, Neoplasm; Drug Administration Schedule; Drug Synergism; Fluorouracil; Folic Acid; Humans; Thymidylate Synthase; Tumor Cells, Cultured | 1996 |
Tumoral-reduced folates and clinical resistance to fluorouracil-based treatment in head and neck cancer patients.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Drug Resistance, Neoplasm; Female; Fluorouracil; Folic Acid; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Staging; Remission Induction | 1997 |
Relevance of tumoral folylpolyglutamate synthetase and reduced folates for optimal 5-fluorouracil efficacy: experimental data.
Topics: Antidotes; Antimetabolites, Antineoplastic; Biopsy; Drug Screening Assays, Antitumor; Drug Synergism; Female; Fluorouracil; Folic Acid; Humans; Leucovorin; Neoplasms; Peptide Synthases; Tumor Cells, Cultured | 1997 |
Nutritional folate status influences the efficacy and toxicity of chemotherapy in rats.
Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Cyclophosphamide; Disease Progression; Doxorubicin; Female; Fluorouracil; Folic Acid; Folic Acid Deficiency; Mammary Neoplasms, Experimental; Neoplasm Transplantation; Nutritional Status; Rats; Rats, Inbred F344; Remission Induction; Tumor Cells, Cultured | 1998 |
Modulation of fluorouracil antitumor activity by folic acid in a murine model system.
Topics: Animals; Antidotes; Antimetabolites, Antineoplastic; Diet; Disease Models, Animal; Drug Synergism; Fluorouracil; Folic Acid; Folic Acid Deficiency; Leucovorin; Mice; Mice, Inbred C3H; Neoplasms, Experimental | 1999 |
[Stability of 5-fluorouracil-folinic acid mixture: influence of concentrations, container and form of folinic acid].
Topics: Antimetabolites, Antineoplastic; Drug Combinations; Drug Packaging; Drug Stability; Fluorouracil; Folic Acid; Hematinics | 1999 |
Folate depletion increases sensitivity of solid tumor cell lines to 5-fluorouracil and antifolates.
Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Carrier Proteins; Colonic Neoplasms; Fluorouracil; Folic Acid; Folic Acid Antagonists; Head and Neck Neoplasms; Humans; Leucovorin; Lung Neoplasms; Membrane Proteins; Membrane Transport Proteins; Mice; Multienzyme Complexes; Neoplasms; Peptide Synthases; Reduced Folate Carrier Protein; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Tumor Cells, Cultured | 2000 |
Effect of consecutive lower-dose cisplatin in enhancement of 5-fluorouracil cytotoxicity in experimental tumor cells in vivo.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Drug Synergism; Enzyme Induction; Fluorouracil; Folic Acid; Male; Methionine; Mice; Neoplasm Transplantation; Oxonic Acid; Pyridines; Rats; Sarcoma, Yoshida; Tegafur | 2000 |
Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Colonic Neoplasms; Diet; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Female; Fluorouracil; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Leucovorin; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Pemetrexed; Quinazolines; Thiophenes; Thymidine; Thymidine Kinase; Thymidylate Synthase | 2001 |
Targeted drug delivery to chemoresistant cells: folic acid derivatization of FdUMP[10] enhances cytotoxicity toward 5-FU-resistant human colorectal tumor cells.
Topics: Antineoplastic Agents; Carrier Proteins; Colorectal Neoplasms; Drug Delivery Systems; Drug Resistance, Neoplasm; Fluorodeoxyuridylate; Fluorouracil; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Membrane Proteins; Membrane Transport Proteins; Receptors, Cell Surface; RNA, Messenger; Thymidylate Synthase; Tumor Cells, Cultured | 2001 |
Mechanism(s) of antitumor action in protracted infusion of low dose 5-fluorouracil and cisplatin in gastric carcinoma.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspase 3; Caspase 8; Caspase 9; Caspases; Cells, Cultured; Cisplatin; Cytochrome c Group; Dihydrouracil Dehydrogenase (NADP); DNA Fragmentation; Dose-Response Relationship, Drug; fas Receptor; Fluorouracil; Folic Acid; Humans; Models, Biological; Oxidoreductases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Signal Transduction; Stomach Neoplasms; Time Factors; Tumor Cells, Cultured | 2002 |
Dietary modulation of mitochondrial DNA deletions and copy number after chemotherapy in rats.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Cyclophosphamide; Diet; DNA, Mitochondrial; Female; Fluorouracil; Folic Acid; Gene Dosage; Mitochondria, Liver; Rats; Rats, Inbred F344; Sequence Deletion | 2002 |
Response to 5-fluorouracil chemotherapy is modified by dietary folic acid deficiency in Apc(Min/+) mice.
Topics: Animals; Antimetabolites, Antineoplastic; Diet; DNA Primers; Fluorouracil; Folic Acid; Folic Acid Deficiency; Genes, APC; Intestinal Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Polymerase Chain Reaction | 2002 |
Diet modulates the toxicity of cancer chemotherapy in rats.
Topics: Animal Feed; Animals; Antimetabolites, Antineoplastic; Cyclophosphamide; Diet; Dietary Supplements; Dose-Response Relationship, Drug; Female; Fluorouracil; Folic Acid; Glutathione; Kidney; Lethal Dose 50; Liver; Longevity; Nutritional Status; Rats; Rats, Inbred F344 | 2002 |
[Operative management in the treatment of pancreatic cancer].
Topics: Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Combined Modality Therapy; Drug Therapy, Combination; Fluorouracil; Folic Acid; Hematinics; Humans; Multicenter Studies as Topic; Neoplasm Metastasis; Pancreatic Neoplasms; Pancreaticoduodenectomy; Prospective Studies; Time Factors | 2003 |
Lethal toxicity of capecitabine due to abusive folic acid prescription?
Topics: Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Deoxycytidine; Drug Interactions; Female; Fluorouracil; Folic Acid; Humans; Middle Aged | 2003 |
Methionine restriction selectively targets thymidylate synthase in prostate cancer cells.
Topics: Antimetabolites, Antineoplastic; Cell Division; Fluorouracil; Folic Acid; Humans; Male; Methionine; Nucleotides; Prostatic Neoplasms; Thymidylate Synthase; Tumor Cells, Cultured | 2003 |
Ineffectiveness of 5-fluoro-2'-deoxyuridine in man after failure of 5-fluorouracil.
Topics: Deoxyuridine; Floxuridine; Fluorouracil; Folic Acid; Humans | 1963 |
ASSOCIATION OF INCREASED DIHYDROFOLATE REDUCTASE LEVELS AND CHROMOSOME ALTERATION IN AMETHOPTERIN-RESISTANT SUBLINES OF LEUKEMIA L1210.
Topics: Animals; Azaserine; Chromosomes; Fluorouracil; Folic Acid; Genetics; Leukemia L1210; Mercaptopurine; Methotrexate; Mice; Oxidoreductases; Research; Tetrahydrofolate Dehydrogenase | 1963 |
EFFECT OF WATER SOLUBLE VITAMINS AND THEIR ANALOGUES ON THE GROWTH OF CANDIDA ALBICANS. I. BIOTIN, PYRIDOXAMINE, PYRIDOXINE AND FLUORINATED PYRIMIDINES.
Topics: Amines; Ascorbic Acid; Biotin; Candida; Candida albicans; Culture Media; Floxuridine; Fluorouracil; Folic Acid; Metabolism; Pharmacology; Pyridoxamine; Pyridoxine; Pyrimidines; Research; Vitamin B 12; Vitamin B Complex; Vitamins | 1963 |
[ANTI-CANCER CHEMOTHERAPY BY PROLONGED INTRA-ARTERIAL INFUSIONS].
Topics: Adrenal Cortex Hormones; Aminocaproates; Aminocaproic Acid; Anti-Bacterial Agents; Chemotherapy, Cancer, Regional Perfusion; Coagulase; Drug Therapy; Fluorouracil; Folic Acid; Humans; Hydrolases; Infusions, Intra-Arterial; Methotrexate; Neoplasms; Thiotepa; Vitamin B Complex | 1965 |
CLOSED PELVIC PERFUSION IN ADVANCED GYNECOLOGIC CANCER.
Topics: Catheterization; Chemotherapy, Cancer, Regional Perfusion; Cyclophosphamide; Female; Fluorouracil; Folic Acid; Genital Neoplasms, Female; Geriatrics; Humans; Lymphography; Neoplasms; Nitrogen Mustard Compounds; Palliative Care; Pelvis; Postoperative Care; Prognosis; Toxicology; Uracil; Uracil Mustard; Urography; Uterine Cervical Neoplasms; Vulvar Neoplasms | 1965 |
Perioperative complications in patients undergoing major liver resection with or without neoadjuvant chemotherapy.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Camptothecin; Colonic Neoplasms; Female; Fluorouracil; Folic Acid; Hepatectomy; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Male; Middle Aged; Neoadjuvant Therapy; Postoperative Complications; Retrospective Studies | 2003 |
Lethal toxicity after 5-fluorouracil chemotherapy and its possible relationship to dihydropyrimidine dehydrogenase deficiency: a case report and review of the literature.
Topics: Antimetabolites, Antineoplastic; Colorectal Neoplasms; Deficiency Diseases; Dihydropyrimidine Dehydrogenase Deficiency; Fatal Outcome; Female; Fluorouracil; Folic Acid; Humans; Middle Aged | 2004 |
Treatment of advanced colorectal and gastric cancer with 5-fluorouracil and calcium n-methyltetrahydrofolate.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Female; Fluorouracil; Folic Acid; Humans; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Stomach Neoplasms; Treatment Outcome | 1989 |
Design and development of folate appended liposomes for enhanced delivery of 5-FU to tumor cells.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Survival; Cholesterol; Drug Delivery Systems; Drug Design; Drug Screening Assays, Antitumor; Fluorouracil; Folic Acid; Inhibitory Concentration 50; Liposomes; Melanoma, Experimental; Mice; Neoplasm Transplantation; Particle Size; Phosphatidylcholines; Polyethylene Glycols | 2007 |
[Therapy of colorectal carcinoma. To combine saves lives].
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chemotherapy, Adjuvant; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Folic Acid; Humans; Multicenter Studies as Topic; Organoplatinum Compounds; Oxaliplatin; Palliative Care; Randomized Controlled Trials as Topic; Time Factors; Vitamin B Complex | 2004 |
Folate and folate-PEG-PAMAM dendrimers: synthesis, characterization, and targeted anticancer drug delivery potential in tumor bearing mice.
Topics: Animals; Antineoplastic Agents; Dendrimers; Drug Carriers; Female; Fluorouracil; Folic Acid; Hemolysis; Mice; Mice, Inbred BALB C; Neoplasms; Polyamines; Polyethylene Glycols; Succinimides; Tissue Distribution | 2008 |
Folate-functionalized nanoparticles for controlled 5-Fluorouracil delivery.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Delayed-Action Preparations; Drug Carriers; Female; Fluorouracil; Folic Acid; Humans; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred BALB C; Microscopy, Electron, Scanning; Molecular Structure; Nanoparticles; Stomach Neoplasms | 2011 |
In vivo evidence for a significant role of folylpolyglutamate synthase in combined chemotherapy with oral fluoropyrimidine, UFT or S-1, and leucovorin.
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Colorectal Neoplasms; Down-Regulation; Fluorouracil; Folic Acid; Gene Expression Regulation, Neoplastic; Humans; Leucovorin; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Peptide Synthases; RNA, Small Interfering; Xenograft Model Antitumor Assays | 2011 |
Folate-conjugated β-cyclodextrin from click chemistry strategy and for tumor-targeted drug delivery.
Topics: Antimetabolites, Antineoplastic; beta-Cyclodextrins; Cell Line, Tumor; Click Chemistry; Drug Carriers; Drug Delivery Systems; Endocytosis; Fluorouracil; Folic Acid; HeLa Cells; Humans; Nanoparticles; Neoplasms; Polyethylene Glycols | 2012 |
Folate intake and methylenetetrahydrofolate reductase gene polymorphisms as predictive and prognostic biomarkers for ovarian cancer risk.
Topics: Biomarkers, Tumor; Case-Control Studies; Cohort Studies; Dietary Supplements; Eating; Feeding Behavior; Female; Fluorouracil; Folic Acid; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Ovarian Neoplasms; Polymorphism, Single Nucleotide; Prognosis; Prospective Studies; Risk; Surveys and Questionnaires | 2012 |
DNA synthesis as a therapeutic target: the first 65 years.
Topics: Aminopterin; Antimetabolites, Antineoplastic; DNA Replication; Fluorouracil; Folic Acid; Folic Acid Antagonists; History, 20th Century; Humans; Hydroxyurea; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase | 2012 |
Multifunctional magnetic fluorescent hybrid nanoparticles as carriers for the hydrophobic anticancer drug 5-fluorouracil.
Topics: Animals; beta-Cyclodextrins; Cell Line; Cell Survival; Drug Carriers; Ferrosoferric Oxide; Fluorouracil; Folic Acid; Glutathione; HeLa Cells; Humans; Hydrophobic and Hydrophilic Interactions; Magnetite Nanoparticles; Mice; Silicon Dioxide; Terbium; Yttrium | 2013 |
Effect of folic acid and vitamin B12 on pemetrexed antifolate chemotherapy in nutrient lung cancer cells.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Dietary Supplements; Drug Screening Assays, Antitumor; Fluorouracil; Folic Acid; Folic Acid Antagonists; G1 Phase; Glutamates; Guanine; Humans; Lung Neoplasms; Neoplasm Proteins; Pemetrexed; Protein Stability; Serum; Treatment Outcome; Vitamin B 12 | 2013 |
γ-Glutamyl hydrolase modulation and folate influence chemosensitivity of cancer cells to 5-fluorouracil and methotrexate.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Colonic Neoplasms; Drug Screening Assays, Antitumor; Female; Fluorouracil; Folic Acid; gamma-Glutamyl Hydrolase; HCT116 Cells; Humans; Male; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Nude; RNA, Small Interfering; Transfection; Xenograft Model Antitumor Assays | 2013 |
Polymorphisms of folate metabolism-related genes and survival of patients with colorectal cancer in the Korean population.
Topics: Aged; Asian People; Colorectal Neoplasms; Female; Fluorouracil; Folic Acid; Humans; Male; Metabolic Networks and Pathways; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Population; Reduced Folate Carrier Protein; Republic of Korea; Survival Analysis; Thymidylate Synthase | 2014 |
Design and evaluation of folate-appended α-, β-, and γ-cyclodextrins having a caproic acid as a tumor selective antitumor drug carrier in vitro and in vivo.
Topics: Animals; Antibiotics, Antineoplastic; Caproates; Cell Line, Tumor; Cyclodextrins; Doxorubicin; Drug Carriers; Drug Screening Assays, Antitumor; Drug Stability; Fluorouracil; Folate Receptor 1; Folic Acid; Humans; Mice, Inbred BALB C; Neoplasm Transplantation; Tumor Burden | 2013 |
[Preoperative chemotherapy in the surgical treatment of colorectal liver metastases].
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Chemotherapy, Adjuvant; Colorectal Neoplasms; Disease-Free Survival; Female; Fluorouracil; Folic Acid; Hepatectomy; Hospitals, General; Humans; Irinotecan; Kaplan-Meier Estimate; Length of Stay; Liver Neoplasms; Male; Middle Aged; Neoadjuvant Therapy; Operative Time; Organoplatinum Compounds; Oxaliplatin; Surgery Department, Hospital; Treatment Outcome | 2013 |
Targeted delivery of 5-fluorouracil to HT-29 cells using high efficient folic acid-conjugated nanoparticles.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Biological Transport; Cell Survival; Colonic Neoplasms; Cross-Linking Reagents; Diamines; Drug Carriers; Drug Compounding; Drug Delivery Systems; Fluorouracil; Folic Acid; HT29 Cells; Humans; Inhibitory Concentration 50; Kinetics; Lactic Acid; Microscopy, Fluorescence; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Surface Properties | 2015 |
Folate-decorated PEG-PLGA nanoparticles with silica shells for capecitabine controlled and targeted delivery.
Topics: Capecitabine; Delayed-Action Preparations; Deoxycytidine; Drug Delivery Systems; Fluorouracil; Folic Acid; Nanoparticles; Polyesters; Polyethylene Glycols; Silicon Dioxide | 2014 |
Folate-polyethylene glycol conjugated carboxymethyl chitosan for tumor-targeted delivery of 5-fluorouracil.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Chitosan; Drug Carriers; Fluorouracil; Folic Acid; HeLa Cells; Hep G2 Cells; Humans; Polyethylene Glycols | 2014 |
Curcumin and 5-fluorouracil-loaded, folate- and transferrin-decorated polymeric magnetic nanoformulation: a synergistic cancer therapeutic approach, accelerated by magnetic hyperthermia.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line; Combined Modality Therapy; Curcumin; Drug Carriers; Fluorouracil; Folic Acid; Humans; Hyperthermia, Induced; Lactic Acid; Magnetite Nanoparticles; MCF-7 Cells; Mice; Nanoconjugates; Nanomedicine; Nanotechnology; Neoplasms; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Transferrin | 2014 |
Hepatocellular carcinoma and nodular regenerative hyperplasia after chemotherapy for metastatic colorectal carcinoma.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Colorectal Neoplasms; Drug Therapy; Fluorouracil; Folic Acid; Hepatectomy; Humans; Hyperplasia; Liver; Liver Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Vascular Diseases | 2014 |
An investigation of antitumor efficiency of novel sustained and targeted 5-fluorouracil nanoparticles.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Fluorouracil; Folic Acid; HCT116 Cells; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Neoplasms, Experimental; Polymers; Structure-Activity Relationship | 2015 |
Inorganic nanovehicle for potential targeted drug delivery to tumor cells, tumor optical imaging.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Chitosan; Drug Carriers; Ferrosoferric Oxide; Fluorouracil; Folic Acid; HEK293 Cells; HeLa Cells; Humans; Magnetite Nanoparticles; Microscopy, Confocal; Nanostructures; Rhodamines; Zirconium | 2015 |
Expression of Folate Pathway Genes in Stage III Colorectal Cancer Correlates with Recurrence Status Following Adjuvant Bolus 5-FU-Based Chemotherapy.
Topics: Adult; Aged; Aged, 80 and over; Chemotherapy, Adjuvant; Colorectal Neoplasms; Disease-Free Survival; Female; Fluorouracil; Folic Acid; Gene Expression Regulation, Neoplastic; Humans; Leucovorin; Male; Middle Aged; Neoplasm Proteins; Neoplasm Recurrence, Local; Neoplasm Staging; Proton-Coupled Folate Transporter; Reduced Folate Carrier Protein; Signal Transduction | 2015 |
Targeted delivery of 5-fluorouracil to cholangiocarcinoma cells using folic acid as a targeting agent.
Topics: Apoptosis; Cell Line, Tumor; Cholangiocarcinoma; Fluorouracil; Folic Acid; Humans; Nanomedicine; Nanoparticles | 2016 |
Impact of multicellular tumor spheroids as an in vivo‑like tumor model on anticancer drug response.
Topics: Adenocarcinoma; Antineoplastic Agents; Colonic Neoplasms; Drug Screening Assays, Antitumor; Fluorouracil; Folic Acid; HT29 Cells; Humans; Liposomes; Organoplatinum Compounds; Oxaliplatin; Spectrophotometry; Spheroids, Cellular | 2016 |
Folic Acid Supplementation Adversely Affects Chemosensitivity of Colon Cancer Cells to 5-fluorouracil.
Topics: Animals; Cell Proliferation; Colonic Neoplasms; Dietary Supplements; Disease Models, Animal; Drug Interactions; Epithelial Cells; Fluorouracil; Folic Acid; Gene Expression Regulation, Neoplastic; HCT116 Cells; Homocysteine; Humans; Male; Mice; Mice, Nude; Multidrug Resistance-Associated Proteins; Xenograft Model Antitumor Assays | 2016 |
In vivo tumor targeting and anti-tumor effects of 5-fluororacil loaded, folic acid targeted quantum dot system.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Fluorouracil; Folic Acid; Humans; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Quantum Dots; Structure-Activity Relationship | 2016 |
Pretreatment Serum Folate Levels and Toxicity/Efficacy in Colorectal Cancer Patients Treated With 5-Fluorouracil and Folinic Acid.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cohort Studies; Colorectal Neoplasms; Female; Fluorouracil; Folic Acid; Humans; Leucovorin; Male; Middle Aged; Prospective Studies | 2016 |
Folic acid-decorated and PEGylated PLGA nanoparticles for improving the antitumour activity of 5-fluorouracil.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line; Chemistry, Pharmaceutical; Colonic Neoplasms; Drug Carriers; Drug Delivery Systems; Female; Fluorouracil; Folic Acid; HT29 Cells; Humans; Inhibitory Concentration 50; MCF-7 Cells; Nanoparticles; Polyesters; Polyethylene Glycols; Tissue Distribution | 2017 |
Fabrication of functional hollow microspheres constructed from MOF shells: Promising drug delivery systems with high loading capacity and targeted transport.
Topics: Biological Transport; Cell Line, Tumor; Cell Survival; Chitosan; Drug Delivery Systems; Drug Liberation; Fluoresceins; Fluorouracil; Folic Acid; Humans; Metal-Organic Frameworks; Microspheres; Nanoparticles; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction | 2016 |
Imaging, biodistribution and in vitro study of smart
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Dendrimers; Female; Fluorouracil; Folic Acid; Humans; Mice; Organotechnetium Compounds; Polyethylene Glycols | 2017 |
Cytocompatible chitosan-graft-mPEG-based 5-fluorouracil-loaded polymeric nanoparticles for tumor-targeted drug delivery.
Topics: Animals; Cell Line; Cell Line, Tumor; Cell Survival; Chitosan; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Fluorouracil; Folic Acid; Humans; MCF-7 Cells; Mice; Nanoparticles; Particle Size; Polyethylene Glycols; Polymers; RAW 264.7 Cells | 2018 |
Post-Synthetic Modification Nanoscale Metal-Organic Frameworks for Targeted Drug Delivery in Cancer Cells.
Topics: A549 Cells; Antineoplastic Agents; Cell Survival; Drug Carriers; Drug Liberation; Fluorouracil; Folic Acid; HeLa Cells; Humans; KB Cells; Metal-Organic Frameworks; Molecular Targeted Therapy; Nanoparticles; Particle Size; Surface Properties; Zinc | 2017 |
Synthesis and characterization of cystamine conjugated chitosan-SS-mPEG based 5-Fluorouracil loaded polymeric nanoparticles for redox responsive drug release.
Topics: Biological Transport; Cell Survival; Chemistry, Pharmaceutical; Chitosan; Cystamine; Drug Delivery Systems; Drug Liberation; Fluorouracil; Folic Acid; Humans; MCF-7 Cells; Nanoparticles; Oxidation-Reduction; Particle Size; Polyethylene Glycols; Surface Properties | 2018 |
Folic acid-modified liposomal drug delivery strategy for tumor targeting of 5-fluorouracil.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Delivery Systems; Fluorouracil; Folic Acid; Liposomes; Male; Mice; Mice, Inbred BALB C; Neoplasms; Rats; Rats, Wistar | 2018 |
The association of polymorphisms in folate-metabolizing genes with response to adjuvant chemotherapy of colorectal cancer.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chemotherapy, Adjuvant; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Folic Acid; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Tetrahydrofolate Dehydrogenase; Young Adult | 2018 |
Chitosan-Carboxymethyl-5-Fluorouracil-Folate Conjugate Particles: Microwave Modulated Uptake by Skin and Melanoma Cells.
Topics: Administration, Cutaneous; Cell Line, Tumor; Chitosan; Drug Delivery Systems; Fluorouracil; Folic Acid; Humans; Melanoma; Membrane Microdomains; Microwaves; Nanoparticles; Skin; Skin Absorption; Skin Neoplasms | 2018 |
Enhancement of 5-Fluorouracil Cytotoxicity by Pyridoxal 5'-Phosphate and Folinic Acid in Tandem.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Colonic Neoplasms; Drug Synergism; Fluorouracil; Folic Acid; HCT116 Cells; HT29 Cells; Humans; Inhibitory Concentration 50; Intracellular Space; Leucovorin; Mice; Pyridoxal Phosphate | 2018 |
Folate-producing lactic acid bacteria reduce inflammation in mice with induced intestinal mucositis.
Topics: Animals; Caco-2 Cells; Cytokines; Diarrhea; Fluorouracil; Folic Acid; Humans; Inflammation; Intestinal Mucosa; Intestines; Lactobacillales; Mice; Mucositis; Probiotics; Streptococcus thermophilus | 2018 |
Development of Folate-Thioglycolate-Gold Nanoconjugates by Using Citric Acid-PEG Branched Polymer for Inhibition of MCF-7 Cancer Cell Proliferation.
Topics: Antineoplastic Agents; Cell Proliferation; Citric Acid; Fluorouracil; Folic Acid; Gold; Humans; MCF-7 Cells; Metal Nanoparticles; Polyethylene Glycols; Thioglycolates | 2018 |
Folic Acid Functionalized Zirconium-Based Metal-Organic Frameworks as Drug Carriers for Active Tumor-Targeted Drug Delivery.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Drug Carriers; Drug Liberation; Fluorouracil; Folic Acid; HeLa Cells; Humans; Metal-Organic Frameworks; Mice; Microscopy, Confocal; Zirconium | 2018 |
Early disease relapse in a patient with colorectal cancer who harbors genetic variants of DPYD, TYMS, MTHFR and DHFR after treatment with 5-fluorouracil-based chemotherapy.
Topics: Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Folic Acid; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Neoplasm Recurrence, Local; Pharmacogenomic Testing; Polymorphism, Genetic; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 2018 |
Magnetic bio-metal-organic framework nanocomposites decorated with folic acid conjugated chitosan as a promising biocompatible targeted theranostic system for cancer treatment.
Topics: Animals; Biocompatible Materials; Cell Death; Cell Line, Tumor; Cell Survival; Chitosan; Curcumin; Drug Liberation; Erythrocytes; Ferric Compounds; Fluorouracil; Folic Acid; Hemolysis; Humans; Magnetic Resonance Imaging; Magnetics; Metal-Organic Frameworks; Mice; Mice, Inbred BALB C; Nanocomposites; Neoplasms; NIH 3T3 Cells; Phantoms, Imaging; Protein Corona; Theranostic Nanomedicine; X-Ray Diffraction | 2019 |
Targeted Transmembrane Delivery of Ca
Topics: Animals; Calcium; Cell Line, Tumor; Cell Proliferation; Cell Survival; Doxorubicin; Drug Carriers; Fluorouracil; Folic Acid; HeLa Cells; Humans; Hydrogels; Hydrogen-Ion Concentration; Ions; Metal Nanoparticles; Mice; Neoplasms; Xenograft Model Antitumor Assays | 2019 |
New folate receptor targeted nano liposomes for delivery of 5-fluorouracil to cancer cells: Strong implication for enhanced potency and safety.
Topics: Apoptosis; Caco-2 Cells; Cell Line, Tumor; Cell Survival; Drug Delivery Systems; Fibroblasts; Fluorouracil; Folic Acid; HeLa Cells; HT29 Cells; Humans; Liposomes; MCF-7 Cells; Microscopy, Electron, Transmission; Nanospheres; Reactive Oxygen Species | 2019 |
Folate pathway genes linked to mitochondrial biogenesis and respiration are associated with outcome of patients with stage III colorectal cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Cell Respiration; Colorectal Neoplasms; Female; Fluorouracil; Folic Acid; Follow-Up Studies; Gene Expression Profiling; Humans; Leucovorin; Male; Middle Aged; Organelle Biogenesis; Oxaliplatin; Prognosis; Retrospective Studies; Survival Rate; Young Adult | 2019 |
A Complete Response Achieved in a Patient with Hepatic Metastasis from Sigmoid Colon Cancer by a Regimen Containing Ramucirumab: a Case Report.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Folic Acid; Humans; Liver Neoplasms; Middle Aged; Oxaliplatin; Prognosis; Ramucirumab; Remission Induction; Sigmoid Neoplasms | 2020 |
Potential thiamine deficiency and neurological symptoms in patients receiving chemotherapy for gastrointestinal cancer.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Female; Fluorouracil; Folic Acid; Gastrointestinal Neoplasms; Humans; Male; Middle Aged; Nervous System Diseases; Retrospective Studies; Risk Factors; Sodium; Thiamine; Thiamine Deficiency; Vitamin B 12; Young Adult | 2020 |
Hollow structural metal-organic frameworks exhibit high drug loading capacity, targeted delivery and magnetic resonance/optical multimodal imaging.
Topics: Drug Carriers; Drug Liberation; Fluorouracil; Folic Acid; Hep G2 Cells; Humans; Magnetic Resonance Imaging; Metal-Organic Frameworks; Multimodal Imaging; Optical Imaging | 2019 |
A Luminescent Amine-Functionalized Metal-Organic Framework Conjugated with Folic Acid as a Targeted Biocompatible pH-Responsive Nanocarrier for Apoptosis Induction in Breast Cancer Cells.
Topics: Amines; Apoptosis; Biocompatible Materials; Breast Neoplasms; Cell Proliferation; Drug Carriers; Drug Liberation; Female; Fluorouracil; Folic Acid; Humans; Luminescent Agents; MCF-7 Cells; Metal-Organic Frameworks; Nanoparticles; Reactive Oxygen Species | 2019 |
Drosha-independent miR-6778-5p strengthens gastric cancer stem cell stemness via regulation of cytosolic one-carbon folate metabolism.
Topics: 14-3-3 Proteins; Animals; Carbon; Cell Line, Tumor; Cytosol; Female; Fluorouracil; Folic Acid; Gene Expression Regulation, Neoplastic; Glycine Hydroxymethyltransferase; Humans; Mice; MicroRNAs; Neoplasm Transplantation; Neoplastic Stem Cells; Ribonuclease III; Stomach Neoplasms; Up-Regulation | 2020 |
Folate-induced nanostructural changes of oligochitosan nanoparticles and their fate of cellular internalization by melanoma.
Topics: Antineoplastic Agents; Cell Line, Tumor; Chitin; Chitosan; Drug Carriers; Fluorouracil; Folic Acid; Humans; Melanoma; Melanoma, Cutaneous Malignant; Nanoparticles; Oligosaccharides; Skin Neoplasms | 2020 |
Functionalized layer-by-layer assembled film with directional 5-fluorouracil release to target colon cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Caco-2 Cells; Capsules; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chitosan; Colonic Neoplasms; Drug Compounding; Fluorouracil; Folic Acid; Humans; Male; Polyesters; Rabbits; Rats; Spheroids, Cellular; Xenograft Model Antitumor Assays | 2020 |
Facile Fabrication of Nanoparticles with Dual-Targeting Ligands for Precise Hepatocellular Carcinoma Therapy
Topics: A549 Cells; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line; Cell Line, Tumor; Chitosan; Fluorouracil; Folic Acid; Hepatocytes; Human Umbilical Vein Endothelial Cells; Humans; Ligands; Liver Neoplasms; Nanoparticles; Precision Medicine; Prodrugs; Solubility | 2020 |
Design of polysaccharidic nano-in-micro soft agglomerates as primary oral drug delivery vehicle for colon-specific targeting.
Topics: Administration, Oral; Alginates; Antimetabolites; Chitosan; Colon; Drug Delivery Systems; Drug Liberation; Fluorouracil; Folic Acid; Humans; Nanoparticles; Pectins; Vitamin B Complex | 2020 |
Evaluation of vitamin-producing and immunomodulatory lactic acid bacteria as a potential co-adjuvant for cancer therapy in a mouse model.
Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents; Breast Neoplasms; Caco-2 Cells; Cell Line; Cell Survival; Cytokines; Disease Models, Animal; Female; Fluorouracil; Folic Acid; Humans; Immunomodulation; Intestinal Mucosa; Lactobacillales; Mice; Mice, Inbred BALB C; Mucositis; Riboflavin; Vitamins | 2021 |
Folate Conjugated Polyethylene Glycol Probe for Tumor-Targeted Drug Delivery of 5-Fluorouracil.
Topics: Animals; Cell Line, Tumor; Chlorocebus aethiops; Fluorouracil; Folic Acid; Humans; Mice; Molecular Docking Simulation; Polyethylene Glycols; Vero Cells | 2022 |
Folate decorated lipid chitosan hybrid nanoparticles of 5-fluorouracil for enhanced anticancer efficacy against colon cancer.
Topics: Cell Line, Tumor; Chitosan; Colonic Neoplasms; Drug Carriers; Drug Delivery Systems; Fluorouracil; Folic Acid; Humans; Lipids; Nanoparticles; Particle Size | 2022 |
Lipid-polymer nanocarrier platform enables X-ray induced photodynamic therapy against human colorectal cancer cells.
Topics: Antineoplastic Agents; Cell Line, Tumor; Colorectal Neoplasms; Fluorouracil; Folic Acid; Humans; Lipids; Nanoparticles; Photochemotherapy; Photosensitizing Agents; Polymers; Reactive Oxygen Species; Verteporfin; X-Rays | 2022 |
A novel sulfated mannan-carboxymethyl-5-fluorouracil-folic acid conjugates for targeted anticancer drug delivery.
Topics: Animals; Antineoplastic Agents; Drug Carriers; Drug Delivery Systems; Fluorouracil; Folic Acid; Humans; Mannans; Mice; Sulfates | 2023 |
Folic-Acid-Conjugated Thermoresponsive Polymeric Particles for Targeted Delivery of 5-Fluorouracil to CRC Cells.
Topics: Colorectal Neoplasms; Drug Carriers; Drug Delivery Systems; Fluorouracil; Folic Acid; Humans; Nanoparticles; Polymers; Quality of Life; Spectroscopy, Fourier Transform Infrared | 2023 |
Design of novel polyurethane-based ionene nanocarriers for cancer therapy: Synthesis, in-vitro, and in-vivo studies.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Carriers; Drug Delivery Systems; Fluorouracil; Folic Acid; Mice; Nanoparticles; Neoplasms; Polyurethanes | 2023 |
Folic Acid-Functionalized Albumin/Graphene Oxide Nanocomposite to Simultaneously Deliver Curcumin and 5-Fluorouracil into Human Colorectal Cancer Cells: An
Topics: Albumins; Colonic Neoplasms; Curcumin; Excipients; Fluorouracil; Folic Acid; Graphite; Humans | 2023 |
Acetylation of aldehyde dehydrogenase ALDH1L2 regulates cellular redox balance and the chemosensitivity of colorectal cancer to 5-fluorouracil.
Topics: Acetylation; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Drug Resistance, Neoplasm; Fluorouracil; Folic Acid; Gene Expression Regulation, Neoplastic; Mice; Mutation; Oxidation-Reduction; Oxidoreductases Acting on CH-NH Group Donors; Sirtuin 3; Up-Regulation | 2023 |
A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance.
Topics: Fluorouracil; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Tetrahydrofolate Dehydrogenase | 2023 |