fluorouracil has been researched along with floxuridine in 843 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 400 (47.45) | 18.7374 |
| 1990's | 197 (23.37) | 18.2507 |
| 2000's | 167 (19.81) | 29.6817 |
| 2010's | 67 (7.95) | 24.3611 |
| 2020's | 12 (1.42) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, MS; Prusoff, WH; Schinazi, RF | 1 |
| Ferguson, PW; Holshouser, MH; Shipp, AM | 1 |
| Cook, AF; Holman, MJ; Kramer, MJ | 1 |
| Chen, R; Farquhar, D; Khan, S | 1 |
| Farquhar, D; Khan, S; Saunders, PP; Srivastva, DN | 1 |
| Baldwin, RW; Bycroft, BW; Chhabra, SR; Garnett, MC; Henn, TF | 1 |
| Balzarini, J; De Clercq, E; Gazivoda, T; Hergold-Brundić, A; Marunović, A; Mintas, M; Nagl, A; Raić-Malić, S; Svedruzić, D | 1 |
| Borch, RF; Tobias, SC | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Cordeiro, MN; Fernández, F; García-Mera, X; Helguera, AM; Rodríguez-Borges, JE | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Grube, M; Guitton, J; Hübner, T; Jedlitschky, G; Köck, K; Kowalczyk, DW; Kroemer, HK; Lerch, MM; Mayerle, J; Mews, S; Nambaru, PK; Payen, L; Rimmbach, C; Ritter, CA; Rosskopf, D; Sendler, M; Weiss, FU | 1 |
| Balzarini, J; Komiotis, D; Liekens, S; Manta, S; Tsoukala, E; Tzioumaki, N; Vande Voorde, J | 1 |
| Balzarini, J; Gonczy, B; Liekens, S; McGuigan, C; Murziani, P; Slusarczyk, M; Vande Voorde, J | 1 |
| Baraniak, D; Celewicz, L; Czarnecka, A; Kleczewska, N; Lewandowska, M; Ruszkowski, P | 1 |
| Antoszczak, M; Celewicz, L; Huczyński, A; Janczak, J; Kleczewska, N; Lewandowska, M; Maj, E; Stefańska, J; Wietrzyk, J | 1 |
| Celewicz, L; Chojnacka, K; Hoffmann, M; Kacprzak, K; Kleczewska, N; Lewandowska, M; Ruszkowski, P | 1 |
| Celewicz, L; Gajecka, M; Klich, K; Kubicka, MM; Przybylski, P; Pyta, K; Ruszkowski, P | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Morgan, MW | 1 |
| Chabner, BA; Donehower, RC; Myers, CE | 1 |
| Chabner, BA; Coleman, CN; Johns, DG; Myers, CE | 1 |
| Grunden, EE; Jato, JG; Johnson, BM; Lake, LM | 1 |
| Forsthoefel, PF; Williams, ML | 1 |
| Morgenthaler, FR; Pettavel, J | 1 |
| Carter, SK; Wasserman, TH | 1 |
| Cove, DJ; Palmer, LM; Scazzocchio, C | 1 |
| Baker, MS; Benedict, WF; Heidelberger, C; Jones, PA; Mondal, S; Rapp, U | 1 |
| Lin, H | 1 |
| Macdonald, JS; Schein, PS; Woolley, PV | 1 |
| Morgenthaler, F; Pettavel, J | 2 |
| Chadwick, M; Chang, C | 1 |
| Buroker, T; Correa, J; Fraile, R; Samson, M; Vaitkevicius, VK | 1 |
| Moertel, CG | 2 |
| Pfefferkorn, ER; Pfefferkorn, LC | 1 |
| Facher, R; Meyer, JS | 1 |
| Schabel, FM | 1 |
| Kramer, PA; Simmons, SP | 1 |
| Pogosiants, EE; Sokova, OI; Volgareva, GM | 1 |
| Ahmed, R; Clouse, ME; McCaffrey, JA; Oberfield, RA; Ryan, RB | 1 |
| Brockman, RW; Rose, LM; Shaddix, SC | 1 |
| Cass, CE; Lynch, TP; Paterson, AR | 1 |
| Mizuno, S; Nitta, K; Tsukeda, H | 1 |
| Lee, YT | 1 |
| Come, S; Ensminger, WD; Frei, E; Glode, M; Levin, DC; Raso, V; Rosowsky, A; Steele, G | 1 |
| Blend, MJ; Forsthoefel, PF; Snow, JW | 1 |
| Danhauser, L; Rustum, YM; Wang, G | 1 |
| Boyd, MR; Buckpitt, AR; Chabner, BA; Jones, RA; Londer, HH; Myers, CE | 1 |
| Houghton, JA; Houghton, PJ; Wooten, RS | 1 |
| Shadomy, S; Wagner, GE | 1 |
| Bowen, D; Diasio, RB; Goldman, ID | 1 |
| Bland, KI; Garrison, RN; Knutson, CO | 1 |
| Clouse, ME; Hamilton, T; McCaffrey, JA; Oberfield, RA; Polio, J | 1 |
| Santi, DV; Washtien, WL | 1 |
| Oberfield, RA | 5 |
| Hanas, RJ; Tlsty, TD; Wilkinson, DS | 1 |
| Glouse, M; Metman, EH; Oberfield, R; Ryan, R | 1 |
| Cady, B; Oberfield, RA; Wellwood, JM | 1 |
| Morgan, MW; O'Hare, MJ | 1 |
| Ashida, N; Baba, M; Ikeda, T; Machida, H; Sakata, S; Shigeta, S | 1 |
| Fujiwara, Y; Nishio, K; Ohe, Y; Ohmori, T; Saijo, N; Sugimoto, Y | 1 |
| Antonakis, K; Halmos, T; Moroni, P; Uriel, J | 1 |
| Khaw, PT; MacKay, SL; Rossi, MJ; Schultz, G; Sherwood, MB | 1 |
| Hoshi, A; Iigo, M; Nishikata, K | 1 |
| Daemen, T; Morselt, H; Regts, J; Scherphof, GL | 1 |
| Araya, S; Fukumoto, M; Hayashi, H; Kawabata, K; Kimura, H; Masai, Y; Meyer, C; Nio, Y; Tseng, CC; Tsubono, M | 1 |
| Kiyabu, M; Laine, L; Leichman, CG; Leichman, L; Muggia, FM; Radin, R; Ray, M; Silberman, H; Spears, CP; Stain, S | 1 |
| Bajetta, E; Colleoni, M; de Braud, F; Nelli, P; Nolè, F; Zilembo, N | 1 |
| Huang, Y; Scher, BM; Scher, M; Waxman, S | 1 |
| Aschele, C; Bertino, JR; Faderan, MA; Sobrero, A | 1 |
| Cloos, J; Noordhuis, P; Peters, GJ; Pinedo, HM; Smid, K; van der Wilt, CL | 1 |
| Encke, A; Hottenrott, C; Inglis, R; Lorenz, M; Maier, P; Reimann, M | 1 |
| Harstrick, A; Rustum, YM; Zhang, ZG | 1 |
| Kemeny, NE | 1 |
| O'Connell, MJ | 1 |
| Barberi-Heyob, M; Merlin, JL; Webér, B | 1 |
| Jampel, HD; Koya, P; Leong, K; Quigley, HA | 1 |
| Senderoff, RI; Smith, DR; Sokoloski, TD; Weber, PA | 1 |
| Ensminger, WD; Greenberg, HS; Lawrence, TS; Mancini, WR; Stetson, PL; Wagner, JG | 1 |
| de Bruijn, EA; Geng, Y; Gheuens, E | 1 |
| Rustum, YM; Yin, MB | 1 |
| Chase, JL; Grobman, BJ; Hohn, DC; Lewis, BJ; Mulvihill, SJ; Rayner, AA; Roh, M; Stagg, RJ; Venook, AP; Warren, RS | 1 |
| Fukuda, S; Iwasaki, Y; Kawai, Y; Miyamoto, H; Nozue, M; Todoroki, T; Ueda, H | 1 |
| Collins, JM | 1 |
| Daher, GC; Diasio, RB; Harris, BE; Willard, EM | 1 |
| Maeda, H; Miyamoto, T; Mochinaga, N; Tsunoda, T | 1 |
| Daher, GC; Diasio, RB; el Kouni, MH; Naguib, FN; Soong, SJ; Zhang, RW | 1 |
| Hiehle, JF; Levine, MS | 1 |
| Bose, S; Chowdhury, M; Chowdhury, SR; Guha, S; Paul, P; Sen, U | 1 |
| Burton, EC; Dusenbury, CE; Ensminger, WD; Jing, HW; Maybaum, J; Shelton, DA; Stetson, PL | 1 |
| Boven, E; Haisma, HJ; Maas, IW; Pinedo, HM; Schlüper, HM | 1 |
| Fujita, H; Hori, T; Mikami, H; Miyata, S; Tai, M | 1 |
| Kubo, M; Sasabe, H; Shimizu, T | 1 |
| Adachi, S; Akaza, H; Ishitsuka, H; Kanazawa, K; Miwa, M; Nitta, K; Sekiguchi, F; Tokita, H | 1 |
| Moran, RG; Scanlon, KL | 1 |
| Bertino, JR; Duafala, ME; Markman, M; Smith-Rogers, JA; Tong, WP | 1 |
| Rustum, YM | 1 |
| Machover, D | 1 |
| Anfossi, A; Anzá, M; Balletto, N; Cavaliere, P; Civalleri, D; Cosimelli, M; Di Tora, P; Durante, F; Mannella, E; Porcellana, M | 1 |
| Da Pian, PP; Lise, M; Nitti, D; Pilati, PL | 1 |
| Akebi, N; Josen, T; Kobashi, K; Matsumura, Y; Nanba, K; Nasu, Y; Ochi, J; Ohmori, H; Saika, T; Tanahashi, T | 1 |
| Allegra, CJ; Chabner, BA; Chu, E; Grem, JL; Johnson, P; Yeh, GC | 1 |
| Hasegawa, K; Ikeda, M; Kinugasa, M; Kobashi, Y; Noda, K; Odagiri, H; Ohiwa, T; Sekiba, K; Takeuchi, K; Watanabe, Y | 1 |
| Akazai, Y; Fuchimoto, S; Iwagaki, H; Matsubara, N; Orita, K; Shiiki, S; Watanabe, T | 1 |
| Altendorf-Hofmann, A; Gall, FP; Scheele, J; Stangl, R | 1 |
| Bishop, JF; Guentert, TW; Hill, HS; Hillcoat, BL; Morris, RG; Olver, IN; Reece, PA | 1 |
| Griffiths, JR; Maxwell, RJ; Prior, MJ | 1 |
| Dallemagne, B; Demoulin, JC; Focan, C; Focan-Henrard, D; Jacquet, N; Jehaes, C; Longrée, L; Markiewicz, S; Mazy, V; Weerts, J | 1 |
| De Clercq, E; Iigo, M; Nakajima, Y; Nishikata, K; Szabolcs, A; Szinai, I; Veres, Z | 1 |
| Curley, SA; Hohn, DC; Roh, MS | 1 |
| Berger, M; Friedl, P; Hull, W; Schlag, P; Yi, J | 1 |
| Eda, H; Fujimoto, K; Ishida, M; Ishitsuka, H; Miwa, M; Ninomiya, Y; Sahara, H; Umeda, I; Yokose, K | 1 |
| Harada, T; Hirano, M; Kikkawa, H; Masuda, S; Matsu, T; Saito, H; Sakatoku, M; Tatsuzawa, T | 1 |
| Imai, S; Morimoto, H; Nio, Y; Shiraishi, T; Tobe, T; Tseng, CC; Tsubono, M | 1 |
| Gayral, F | 1 |
| Tuchmann, A | 1 |
| De Clercq, E; Iigo, M; Miwa, M | 1 |
| Aschele, C; Guglielmi, A; Nobile, MT; Rosso, R; Sobrero, A | 1 |
| Bertino, JR; Carotti, S; Coronnello, M; Gerli, A; Mazzei, T; Mini, E; Moroson, BA; Periti, P; Pesciullesi, A | 1 |
| Aikawa, T; Hirai, T; Kaji, M; Kitada, M; Kotsuma, Y; Maeura, Y; Miyauchi, K; Satomi, T; Takatsuka, Y; Yayoi, E | 1 |
| Fitzgibbons, RJ; Krook, JE; Mailliard, JA; Martin, JK; Nagorney, DM; O'Connell, MJ; Rubin, J; Tschetter, LK; Wieand, HS | 1 |
| Foth, H; Kahl, GF; Kunellis, EM; Müseler, T | 1 |
| Arai, Y; Endo, T; Kido, C; Miyake, Y | 1 |
| Hrushesky, WJ | 4 |
| Izumi, T; Kumagai, K; Kurihara, M; Masuo, K; Nishida, Y; Sanada, Y; Yasui, A | 1 |
| Beger, HG; Bittner, R; Roscher, R; Safi, F; Schumacher, K | 1 |
| Bertino, JR; Romanini, A | 1 |
| Inaba, M; Mitsuhashi, J; Ozawa, S | 1 |
| Beatty, JD; Hill, LR; Kemeny, MM; Kokal, WA; Leong, L; Riihimaki, DU; Terz, JJ; Wagman, LD | 1 |
| Adachi, I; Douden, K; Hayashi, H; Hikishima, H; Iwa, T; Munemoto, Y; Okada, Y; Omura, K; Watanabe, Y | 1 |
| Bruso, CE; Lawrence, TS; Shewach, DS | 1 |
| Cha, S; Darnowski, JW; el Kouni, MH; Naguib, FN; Park, KS; Soong, SJ | 1 |
| Hirose, S; Kito, M; Takeshima, S; Urakami, K; Yoshida, S | 1 |
| Allegra, C; Gazdar, AF; Kramer, BS; Perng, RP; Tsai, CM | 1 |
| Lankelma, J; Laurensse, E; Leyva, A; Peters, GJ; Pinedo, HM | 1 |
| Fukushima, T; Hara, Y; Hashimoto, T; Hirakawa, T; Kono, A; Tanaka, M; Tomonaga, M; Yamashita, M | 1 |
| Laurensse, E; Leyva, A; Peters, GJ; Pinedo, HM | 1 |
| Armstrong, RD; Cadman, EC; Takimoto, CH; Tan, YY | 1 |
| Crissman, HA; Elias, L | 1 |
| Herrmann, R | 2 |
| Porschen, R; Strohmeyer, G | 1 |
| Aiba, K; Allegra, CJ; Baram, J; Chabner, BA; Curt, GA; Yeh, GC | 1 |
| Anderson, N; Bern, M; Lokich, J; Moore, C; Wallach, S; Williams, D | 1 |
| Anderson, N; Bern, M; Lokich, J; Moore, C; Umprayn, V; Wallach, S; Williams, D | 1 |
| Morgan, RG | 1 |
| Lönn, S; Lönn, U; Nylen, U; Winblad, G | 1 |
| Ando, J; Kosaka, A; Sumiyoshi, K | 1 |
| Braakhuis, BJ; de Bruijn, EA; Laurensse, EJ; Peters, GJ; Pinedo, HM; van Walsum, M | 1 |
| LaCreta, FP; Warren, BS; Williams, WM | 1 |
| Araki, E; Hoshi, A; Iigo, M; Nakajima, Y | 1 |
| Baba, T; Furukohri, N; Itoh, T; Munakata, A; Ogasawara, H; Saitoh, S; Sakata, Y; Tamura, Y; Tsushima, K; Yoshida, Y | 1 |
| De Clercq, E; Hoshi, A; Iigo, M; Nakajima, Y; Nishikata, K; Odagiri, H; Okudaira, N | 1 |
| Kesseler, J; Ploss, HJ; Schmitz, R; Zanea-Wangler, E | 1 |
| Barkun, J; Klauke, H; Krakamp, B; Mennigen, R; Schmitz, R | 1 |
| Bertino, JR; Nicolin, A; Romanini, A; Rosso, R; Russello, O; Sobrero, A | 1 |
| Droz, JP; Ducreux, M; Elias, D; Ghosn, M; Lasser, P; Lumbroso, J; Rougier, P; Sidibe, S | 2 |
| Ajani, JA; Carrasco, CH; Jackson, DE; Wallace, S | 1 |
| Ishikawa, T; Ishitsuka, H; Ohkawa, T; Tanaka, Y | 1 |
| Danenberg, KD; Danenberg, PV | 1 |
| Katsuki, Y; Nishimura, A; Tsuji, Y; Yasuda, T | 1 |
| Beger, HG; Bitter, R; Gaus, W; Roscher, R; Safi, F; Schumacher, KA | 1 |
| Goto, M; Maeda, T; Misaki, O; Okamoto, Y; Okamura, S; Sugimoto, O; Ueda, M; Ueki, M; Yamada, T | 1 |
| Didolkar, MS | 1 |
| Hottenrott, C; Inglis, R; Kirkowa-Reimann, M; Lorenz, M | 1 |
| Ho, DH; Kamiya, K; Nakamura, T; Sasaki, K; Tsutani, H; Uchida, M; Yoshimura, T | 1 |
| Braakhuis, BJ; Laurensse, EJ; Peters, GJ; Pinedo, HM | 1 |
| Darland, G; Kaplan, L; Rosenbach, M | 1 |
| Armand, JP; De Forni, M; Malet-Martino, MC; Martino, R | 1 |
| Bertino, JR; Chang, YM | 1 |
| Blijham, G; Neyt, JP; Planting, AS; Runhaar, EA; Taal, BG; Verwey, J | 1 |
| Kashani-Sabet, M; Scanlon, KJ; Sowers, LC | 1 |
| Au, JL; Su, MH; Wientjes, MG | 1 |
| Hottenrott, C; Lorenz, M | 1 |
| Glazer, RI; Iigo, M | 1 |
| Endoh, F; Fujimoto, S; Igarashi, K; Kawata, S; Miyazaki, M; Ohta, M; Shimura, T; Shrestha, RD; Sugasawa, H; Takahashi, O | 1 |
| Chapman, J; Chinn, B; Duffin, H; Enochs, K; Groshko, G; Maniscalco, E; Reznik, S; Vaughn, CB; Young, S; Zaks, J | 1 |
| Boothman, DA; Greer, SB; Mekras, JA | 1 |
| de Bruijn, EA; Pinedo, HM; Reeuwijk, HJ; Tjaden, UR; van Oosterom, AT | 1 |
| Edwards, IR; Ferry, DG; Hung, CT; Perrier, DG; Schaaf, LJ | 1 |
| Benson, AB; Cummings, KB; Fischer, PH; Trump, DL | 1 |
| Daly, JM; Ridge, JA | 1 |
| Baba, H; Kunimoto, T; Nitta, K; Sasaki, T; Takeuchi, M; Tanaka, T; Uehara, N | 1 |
| Donegan, WL | 1 |
| Crea, P; Stephens, FO; Walker, PJ | 1 |
| Kada, T; Ohta, T; Shirasu, Y; Tsukamoto, R; Watanabe, M | 1 |
| Ottery, FD; Scupham, RK; Weese, JL | 1 |
| Hiraoka, O; Hirota, Y; Koyama, Y; Tanaka, S; Wataya, Y; Yoshioka, A | 1 |
| Armand, JP; Bernadou, J; Béteille, JP; Bon, M; Lopez, A; Malet-Martino, MC; Martino, R | 1 |
| Chisholm, EM; Finan, PJ; Giles, GR; Woodhouse, L | 2 |
| Aguiar, JL; Bartkowski, R; Berger, MR; Dörsam, J; Geelhaar, GH; Henne, TH; Herfarth, C; Schlag, P | 1 |
| Coronnello, M; Criscuoli, L; Gualtieri, M; Mazzei, T; Mini, E; Periti, P | 2 |
| Alison, DL; Calvert, AH; Harrap, KR; Jackman, AL | 1 |
| Heath, TD; Lewis, GP; Lopez, NG; Stern, WH | 1 |
| Armstrong, RD; Cadman, EC; Takimoto, CH | 1 |
| Clark, CG | 1 |
| Holl, E; Lange, J; Siewert, JR; Zänker, KS | 1 |
| Endoh, F; Fujimoto, S; Igarashi, K; Miyazaki, M; Ohta, M; Okui, K; Shrestha, RD; Togawa, Y | 1 |
| Ramirez, G; Weese, JL | 1 |
| Lönn, S; Lönn, U | 2 |
| Lokich, JJ | 1 |
| Aguiar, JL; Bartkowski, R; Berger, MR; Dörsam, J; Geelhaar, GH; Henne, TH; Herfarth, C; Schlag, P; Schmähl, D | 1 |
| Bollag, W; Hartmann, HR | 2 |
| Keyomarsi, K; Moran, RG | 3 |
| Faure, F; Hollande, E; Malet-Martino, MC; Martino, R; Palevody, C; Vialaneix, JP | 1 |
| Lankelma, J; Laurensse, EJ; Leyva, A; Peters, GJ; Pinedo, HM; van Dijk, J; van Groeningen, C | 1 |
| Fischer, PH; Grem, JL | 1 |
| Fosså, SD; Heier, MS; Heintz, R | 1 |
| Hori, M; Kano, T; Mizuno, K; Nishida, Y; Ohta, M; Okamoto, E; Sakakibara, K; Tokuhashi, Y; Tomita, Y; Yoshio, G | 1 |
| Flentje, D; Flentje, M; Schlag, P | 1 |
| Au, JL; Canobbio, L; Rustum, YM; Trave, F | 1 |
| Chen, TS; Huang, KC; Warren, BS; Williams, WM | 1 |
| DeSimone, P; MacDonald, J; Maruyama, Y; Raju, PI | 1 |
| Blumenkranz, MS; Hajek, AS; Hartzer, MK | 1 |
| Bertino, JR; Mini, E; Moroson, BA | 1 |
| Cook, A; Ishitsuka, H; Miwa, M | 1 |
| Boothman, DA; Briggle, TV; Greer, S | 1 |
| LaCreta, FP; Williams, WM | 1 |
| Fujita, F; Fujita, M; Inaba, H; Sakamoto, Y; Shimozuma, K; Taguchi, T | 1 |
| Taguchi, T | 2 |
| Fujii, S | 1 |
| Balch, CM; Levin, B | 1 |
| Berg-Johnsen, J; Heier, MS; Langmoen, IA | 1 |
| Bertino, JR; Coronnello, M; Criscuoli, L; Gualtieri, M; Mazzei, T; Mini, E; Periti, P | 1 |
| Ishitsuka, H; Kamiyama, T; Miwa, M; Nishimura, J | 1 |
| Miller, DM; Monk, MR; Phelps, CD; Sanchez, JD | 1 |
| Fisher, K; Flam, M; Gandara, D; Hannigan, J; Hendrickson, C; Kohler, M; Richman, E; Valone, FH; Yu, KP | 1 |
| Cohen, CJ; Dottino, PR; Goodman, HM; Kredenster, D; Mark, M; Runowicz, C | 1 |
| Barnes, S; Diasio, RB; Sweeny, DJ | 1 |
| Eda, H; Fujimoto, K; Fukuda, H; Ishitsuka, H; Miwa, M | 1 |
| Au, JL; Rustum, YM; Slocum, HK | 1 |
| Ajmera, S; Bapat, AR; Danenberg, PV; Stephanian, E | 1 |
| Alberto, P; Cavalli, F; Germano, G; Joss, R; Kaplan, S; Martz, G; Mermillod, B; Spati, B; Weber, W | 1 |
| Alley, PA; Choong, YS; Lee, SP | 1 |
| Brouwers, JR; Koks, CH; Sleijfer, DT | 1 |
| Aigner, KR; Danenberg, PV; Link, KH; Peschau, K; Schwemmle, K; Warthona, M | 1 |
| Ichihara, S; Kuruma, I; Odagiri, H; Semura, E; Tateishi, M; Utoh, M | 1 |
| Malik, ST; Wrigley, PF | 1 |
| Almersjö, O; Berne, M; Gustavsson, B; Spears, P; Sundström, E | 1 |
| Aigner, F; Margreiter, R; Pernthaler, H; Schmid, T; Steiner, E; Then, P | 1 |
| Allegra, CJ; Collins, JM; Gazdar, AF; Greene, RF; Kramer, BS; Park, JG; Steinberg, SM | 1 |
| Cagnazzo, P; Cardi, G; Ficorella, C; Frati, L; Marchei, P; Marchetti, P; Ricciuti, FP | 1 |
| Glimelius, B; Påhlman, L | 1 |
| Dobbs, BR; Edwards, IR; Perrier, DG; Schaaf, LJ | 2 |
| Lin, FH; Williams, WM | 1 |
| Zhao, B; Zhao, XL | 1 |
| Muhrer, KH; Schwemmle, K | 1 |
| Laurensse, EJ; Peters, GJ; Pinedo, HM | 1 |
| Hattori, T; Hirabayashi, N; Kirihara, Y; Niimoto, M; Nishiyama, M; Nosoh, Y; Saeki, T; Takagami, S | 1 |
| Keyomarsi, K; Moran, RG; Patel, R | 1 |
| Taylor, I | 1 |
| Dahl, O; Fosså, SD; Heier, M; Hoel, R; Loeb, M | 1 |
| Byfield, JE | 1 |
| Bernheim, JL; De Dobbeleer, GB; Roobol, C | 2 |
| Hoshi, A; Iigo, M; Nishimura, S; Yamaizumi, Z | 1 |
| Cranford, SK; Fernandes, DJ | 1 |
| Abe, Y; Ido, T; Ishiwata, K; Matsuzawa, T; Murakami, M | 1 |
| Jones, RB | 1 |
| Applefeld, MM; Newman, KA; Reed, WP; Sutton, FJ | 1 |
| Benedict, WF; Heidelberger, C; Peterson, AR | 1 |
| Aoyama, A; Hirata, K; Niitani, H; Ootsuka, M; Shibuya, M; Shimabukuro, Z; Yano, T | 1 |
| Cohen, AM; Kaufman, SD; Wood, WC | 1 |
| Lin, F; Warren, BS; Williams, WM | 1 |
| Choong, YS; Lee, SP | 1 |
| Johnson, RO; Sedransk, N; Shingleton, WW | 1 |
| Couture, J; Deschênes, L | 1 |
| Greenwald, ES | 1 |
| Bagshaw, MA; Goffinet, DR | 1 |
| Bean, B; Tomasz, A | 2 |
| Liebman, IM; Maguire, HC | 1 |
| Cheng, CC | 1 |
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| Capanu, M; Chatila, WK; Chou, JF; Connell, LC; D'Angelica, MI; Jarnagin, WR; Kemeny, NE; Kingham, TP; Sanchez-Vega, F; Shi, H | 1 |
| Jangili, P; Kim, JH; Kim, JS; Kong, N; Liu, H; Tao, W; Zhang, X; Zhou, J | 1 |
| Billingsley, KG; Dewey, EN; Herzig, DO; Kolbeck, KJ; Korngold, EK; Lopez, CD; Mayo, SC; Nabavizadeh, N; Sutton, TL; Walker, BS | 1 |
| Borro, M; De Bernardini, D; De Luca, O; Gentile, G; Lionetto, L; Salerno, G; Simmaco, M; Torre, MS | 1 |
| Chang, I; Chang, WJ; Chen, R; Circelli, J; Harpel, Z; Rivera, J; Wei, R; Wu, S | 1 |
| BOLAFFI, JL; CHEONG, L; EIDINOFF, ML; KNOLL, JE; RICH, MA | 1 |
| BURCHENAL, JH; CLARKSON, B; GLATSTEIN, N; MILLER, E; SULLIVAN, RD; YOUNG, CW | 1 |
| BURCHENAL, JH; ELLISON, RR; ESCHER, G; KARNOFSKY, DA; KAUFMAN, R; LEVICK, SN; LI, MC; MILLER, E; SULLIVAN, RD; WOLDOW, I; YOUNG, CW | 1 |
| NICHOL, CA; WHITE, PJ | 1 |
| Gero, AM; Lutze-Mann, LH; Murray, V; Taylor, CB | 1 |
| Beijnen, JH; Derissen, EJ; Huitema, AD; Jacobs, BA; Rosing, H; Schellens, JH | 1 |
| Beumer, JH; Eiseman, JL; Holleran, JL; Kummar, S; Parise, RA | 1 |
| Andersen, EC; García-González, AP; Ritter, AD; Shrestha, S; Walhout, AJM; Yilmaz, LS | 1 |
| Allen, PJ; Balachandran, VP; Boucher, T; Capanu, M; Cercek, A; Chou, JF; D'Angelica, MI; DeMatteo, RP; Jarnagin, WR; Kemeny, NE; Kingham, TP; Pak, LM | 1 |
| Aviñó, A; Eritja, R; Fàbrega, C; Jorge, AF; Pais, AACC | 1 |
| Aziz, MY; Azizi, J; Kamaruzaman, S; Keyon, ASA; Mohamad Zain, NN; Noordin, SS; Saad, B; Semail, NF; Waras, MN; Yahaya, N | 1 |
| Clua, A; Eritja, R; Fàbrega, C; García-Chica, J; Grijalvo, S | 1 |
| Cui, S; Jiang, L; Liu, X; Luo, D; Lv, Q; Pan, T; Qu, X; Wan, S; Yuan, W | 1 |
109 review(s) available for fluorouracil and floxuridine
| Article | Year |
|---|---|
The clinical pharmacology of antineoplastic agents (first of two parts).
Topics: Animals; Antineoplastic Agents; Asparaginase; Binding Sites; Biological Transport; Chemical and Drug Induced Liver Injury; Depression, Chemical; DNA, Neoplasm; Drug Interactions; Drug Resistance; Floxuridine; Fluorouracil; Folic Acid Antagonists; Humans; Kidney Diseases; Liver; Lung Diseases; Methotrexate; Mice; Neoplasms; Tetrahydrofolate Dehydrogenase | 1975 |
Chemotherapy of colorectal carcinoma.
Topics: Administration, Oral; Antineoplastic Agents; Carmustine; Colonic Neoplasms; Drug Administration Schedule; Drug Therapy, Combination; Floxuridine; Fluorouracil; Humans; Mitomycins; Perfusion; Rectal Neoplasms; Semustine; Time Factors | 1976 |
Rationale for adjuvant chemotherapy.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carmustine; Cyclophosphamide; Cytarabine; Doxorubicin; Drug Therapy, Combination; Female; Floxuridine; Fluorouracil; Humans; Lung Neoplasms; Mammary Neoplasms, Experimental; Mice; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental | 1977 |
Nonsystemic treatment of metastatic tumors of the liver--a review.
Topics: Antineoplastic Agents; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Ligation; Liver Neoplasms; Middle Aged; Neoplasm Metastasis | 1978 |
Is hepatic infusion of chemotherapy effective treatment for liver metastases? Yes!
Topics: Actuarial Analysis; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Dexamethasone; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusion Pumps; Infusions, Intra-Arterial; Infusions, Intravenous; Liver Diseases; Liver Neoplasms; Quality of Life; Retrospective Studies; Survival Analysis | 1992 |
Is hepatic infusion of chemotherapy effective treatment for liver metastases? No!
Topics: Antineoplastic Agents; Colorectal Neoplasms; Floxuridine; Fluorouracil; Forecasting; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Injections, Intravenous; Leucovorin; Liver Neoplasms; Mitomycin; Survival Rate | 1992 |
Biochemical basis for circadian-dependent metabolism of fluoropyrimidines.
Topics: Animals; Circadian Rhythm; Dihydrouracil Dehydrogenase (NADP); Floxuridine; Fluorouracil; Humans; Oxidoreductases; Thymidine Phosphorylase | 1991 |
Modulation of fluoropyrimidines by leucovorin: rationale and status.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Administration Schedule; Floxuridine; Fluorouracil; Humans; Leucovorin | 1991 |
Developments of the fluoropyrimidines as inhibitors of thymidylate synthetase: pharmacologic and clinical aspects.
Topics: Animals; Antineoplastic Agents; Colorectal Neoplasms; Drug Synergism; Floxuridine; Fluorouracil; Humans; Leucovorin; Organoplatinum Compounds; Prodrugs; Pyrimidines; Thymidylate Synthase | 1991 |
Antimetabolites.
Topics: Animals; Antimetabolites; Antineoplastic Agents; Cytarabine; Cytidine; Drug Interactions; Drug Resistance; Floxuridine; Fluorouracil; Folic Acid Antagonists; Humans; Methotrexate; Neoplasms | 1991 |
[Intra-arterial and intravenous chemotherapy in the treatment of hepatic metastases of colorectal origin: review of the literature and preliminary results].
Topics: Aged; Antineoplastic Agents; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusion Pumps; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Portal Vein | 1990 |
[Treatment of hepatic metastases].
Topics: Adult; Aged; Female; Floxuridine; Fluorouracil; Hepatectomy; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Liver Neoplasms; Liver Transplantation; Male; Middle Aged; Multivariate Analysis; Prognosis; Survival Rate | 1990 |
[Intra-arterial chemotherapy of the liver].
Topics: Antineoplastic Combined Chemotherapy Protocols; Catheters, Indwelling; Floxuridine; Fluorouracil; Hepatectomy; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms | 1990 |
Biochemical modulation of fluoropyrimidines by antifolates and folates in an in vitro model of human leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Floxuridine; Fluorouracil; Folic Acid; Folic Acid Antagonists; Humans; Leukemia, Experimental | 1990 |
More evidence for circadian rhythm effects in cancer chemotherapy: the fluoropyrimidine story.
Topics: Circadian Rhythm; DNA; Floxuridine; Fluorouracil; Humans; Neoplasms | 1990 |
[Interdisciplinary therapy concepts in primary and secondary neoplasms of the liver].
Topics: Carcinoma, Hepatocellular; Combined Modality Therapy; Floxuridine; Fluorouracil; Follow-Up Studies; Gastrointestinal Neoplasms; Humans; Liver Neoplasms | 1989 |
Antimetabolites.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Cytarabine; Floxuridine; Fluorouracil; Folic Acid Antagonists; Humans; Mercaptopurine; Methotrexate; Purines; Thioguanine | 1987 |
Leucovorin enhancement of the effects of the fluoropyrimidines on thymidylate synthase.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Synergism; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Leucovorin; Neoplasms; Thymidylate Synthase | 1989 |
Treatment of colorectal hepatic metastases.
Topics: Antineoplastic Agents; Colonic Neoplasms; Combined Modality Therapy; Drug Administration Schedule; Floxuridine; Fluorouracil; Hepatectomy; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Prognosis; Radiotherapy Dosage; Rectal Neoplasms | 1985 |
Cytostatic drug therapy in disseminated colorectal cancer.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Leucovorin; Methotrexate; Semustine; Vincristine | 1988 |
[Therapy concepts in colorectal liver metastases. What is proven, what is open to discussion?].
Topics: Colorectal Neoplasms; Combined Modality Therapy; Floxuridine; Fluorouracil; Hepatectomy; Humans; Infusions, Intra-Arterial; Liver Neoplasms | 1988 |
Adjuvant cytotoxic chemotherapy for colorectal cancer: the present position.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Combined Modality Therapy; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Liver Neoplasms; Neoplasm Recurrence, Local; Neoplasm Staging; Postoperative Period; Random Allocation; Semustine | 1988 |
Oncogenic transformation of C3H/10T1/2 Cl 8 mouse embryo fibroblasts by inhibitors of nucleotide metabolism.
Topics: Animals; Bromodeoxyuridine; Cell Line; Cell Transformation, Neoplastic; Cytidine; Deoxycytidine; Deoxyribonucleotides; DNA; Embryo, Mammalian; Fibroblasts; Floxuridine; Fluorouracil; Idoxuridine; Methotrexate; Mice; Mice, Inbred C3H; Mutation; Thymidine; Trifluridine | 1985 |
Cancer chemotherapy. II.
Topics: Animals; Antineoplastic Agents; Asparaginase; Azathioprine; Bleomycin; Cytarabine; Dactinomycin; Daunorubicin; Dimethylamines; Doxorubicin; Floxuridine; Fluorouracil; Humans; Hydroxyurea; Imidazoles; Mercaptopurine; Mitomycins; Mitotane; Neoplasms; Nitrosourea Compounds; Pipobroman; Procarbazine; Streptonigrin; Streptozocin; Thioguanine; Triazenes; Triazines; Vinblastine; Vincristine | 1972 |
Clinical use of radiation sensitizing agents.
Topics: Animals; Antimetabolites, Antineoplastic; Bleomycin; Bromodeoxycytidine; Bromodeoxyuridine; Bromouracil; Carcinoma, Squamous Cell; Dactinomycin; Dose-Response Relationship, Radiation; Floxuridine; Fluorouracil; Head and Neck Neoplasms; Humans; Hydroxyurea; Idoxuridine; Neoplasms; Neoplasms, Experimental; Radiation-Sensitizing Agents | 1974 |
Some pyrimidines of biological and medicinal interest. I.
Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Antimalarials; Antimetabolites; Antithyroid Agents; Bacteria; Bromine; Chlorine; Floxuridine; Fluorine; Fluorouracil; Humans; Iodine; Pyrimethamine; Pyrimidines; Rodenticides; Sulfonamides | 1969 |
Solid tumor chemotherapy: What have we to offer.
Topics: Adult; Antineoplastic Agents; Child; Cyclophosphamide; Dactinomycin; Floxuridine; Fluorouracil; Humans; Hydroxyurea; Methotrexate; Neoplasms; Nitrogen Mustard Compounds; Palliative Care; Thiotepa; Time Factors; Vincristine | 1970 |
Fluorinated pyrimidines.
Topics: Animals; Carcinoma, Ehrlich Tumor; Clinical Trials as Topic; DNA; DNA Viruses; Enzyme Induction; Floxuridine; Fluorouracil; Humans; Ligases; Protein Biosynthesis; RNA Viruses | 1965 |
[Chemotherapy of cancer of the rectum and the colon].
Topics: Antimetabolites; Colonic Neoplasms; Drug Synergism; Floxuridine; Fluorouracil; Humans; Injections, Intra-Arterial; Injections, Intravenous; Liver Neoplasms; Mitomycins; Neoplasm Metastasis; Rectal Neoplasms | 1970 |
5-Fluorouracil in the treatment of gastrointestinal neoplasia.
Topics: Administration, Oral; Antineoplastic Agents; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Humans; Injections, Intravenous; Liver Neoplasms; Neoplasm Metastasis; Remission, Spontaneous; Time Factors | 1973 |
Lysogenic induction.
Topics: Animals; Bacteria; Bacteriolysis; Bacteriophages; Cell Transformation, Neoplastic; Chromosomes; Coliphages; Conjugation, Genetic; Crosses, Genetic; DNA, Bacterial; DNA, Viral; Escherichia coli; Floxuridine; Fluorouracil; Genes; Lysogeny; Mitomycins; Mutation; Thymine; Transcription, Genetic; Ultraviolet Rays; Virus Replication | 1973 |
A review of chemotherapy in gastric cancer.
Topics: Adenocarcinoma; Antineoplastic Agents; Carmustine; Chlorambucil; Chromomycins; Cyclophosphamide; Cytarabine; Drug Evaluation; Drug Therapy, Combination; Floxuridine; Fluorouracil; Humans; Mechlorethamine; Methotrexate; Mitomycins; Nitrosourea Compounds; Olivomycins; Stomach Neoplasms | 1974 |
Chemotherapy of residual disease in solid tumours.
Topics: Colonic Neoplasms; Cyclophosphamide; Floxuridine; Fluorouracil; Head and Neck Neoplasms; Humans; Lung Neoplasms; Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds; Rectal Neoplasms; Stomach Neoplasms; Thiotepa; Wilms Tumor | 1971 |
The pharmacology of prodrugs of 5-fluorouracil and 1-beta-D-arabinofuranosylcytosine.
Topics: Acylation; Ancitabine; Animals; Antineoplastic Agents; Chemistry, Pharmaceutical; Cytarabine; Floxuridine; Fluorouracil; Humans; Phospholipids; Pyrimidines; Steroids; Tegafur | 1984 |
Intraarterial hepatic infusion chemotherapy in metastatic liver cancer.
Topics: Antineoplastic Agents; Colonic Neoplasms; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Rectal Neoplasms | 1983 |
Comparison of systemic chemotherapy with hepatic arterial infusion in metastatic colorectal carcinoma.
Topics: Antineoplastic Agents; Catheterization; Colonic Neoplasms; Drug Therapy, Combination; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Prospective Studies; Random Allocation; Rectal Neoplasms | 1983 |
Hepatic arterial chemotherapy for colorectal cancer metastatic to the liver.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Mitomycins; Rectal Neoplasms | 1984 |
Selective uptake and retention of anticancer agents by sensitive cells.
Topics: Animals; Antineoplastic Agents; Cytarabine; Doxorubicin; Floxuridine; Fluorouracil; Humans; Melphalan; Methotrexate; Neoplasms | 1980 |
Drug-induced megaloblastic change.
Topics: Cyclophosphamide; Cytarabine; DNA; Erythrocytes, Abnormal; Floxuridine; Fluorouracil; Folic Acid Antagonists; Humans; Hydroxyurea; Megaloblasts; Methotrexate; Phenytoin; Pyrimethamine; Ribonucleotides; Thymidine Monophosphate; Thymidylate Synthase; Triamterene; Trimethoprim | 1980 |
[Results of resection and adjuvant therapy of liver metastases of primary colorectal tumors--a review of the literature].
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Chemotherapy, Adjuvant; Chemotherapy, Cancer, Regional Perfusion; Colorectal Neoplasms; Combined Modality Therapy; Disease-Free Survival; Floxuridine; Fluorouracil; Follow-Up Studies; Hepatectomy; Humans; Immunotherapy, Active; Infusions, Intra-Arterial; Liver Neoplasms; Treatment Outcome | 1995 |
Prolonged infusion of fluorinated pyrimidines in gastrointestinal malignancies: a review of recent clinical trials.
Topics: Carcinoma, Squamous Cell; Circadian Rhythm; Cisplatin; Clinical Trials as Topic; Colorectal Neoplasms; Drug Administration Schedule; Esophageal Neoplasms; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Interferons; Leucovorin | 1994 |
[What is the value of arterial chemotherapy in treatment of colorectal liver metastases].
Topics: Antineoplastic Agents; Chemotherapy, Adjuvant; Clinical Trials as Topic; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Palliative Care; Survival Rate; Treatment Outcome | 1994 |
[Adjuvant and palliative regional therapy of liver metastases in colorectal tumors].
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Chemotherapy, Cancer, Regional Perfusion; Colorectal Neoplasms; Combined Modality Therapy; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Palliative Care; Randomized Controlled Trials as Topic; Time Factors | 1995 |
Update on regional treatments for hepatobiliary malignancies.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biliary Tract Neoplasms; Carcinoma, Hepatocellular; Colorectal Neoplasms; Cryosurgery; Cryotherapy; Doxorubicin; Ethanol; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Injections, Intralesional; Liver Neoplasms; Male; Treatment Outcome | 1995 |
Current status of radiation sensitization by fluoropyrimidines.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Combined Modality Therapy; Digestive System Neoplasms; DNA, Neoplasm; Floxuridine; Fluorouracil; Humans; Radiation-Sensitizing Agents; Survival Rate; Tumor Cells, Cultured; Urologic Neoplasms | 1995 |
Clinical cancer chronotherapy trials: a review.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Circadian Rhythm; Clinical Trials as Topic; Drug Administration Schedule; Floxuridine; Fluorouracil; Humans; Neoplasms; Randomized Controlled Trials as Topic | 1995 |
Cancer chronotherapy: is there a right time in the day to treat?
Topics: Animals; Antineoplastic Agents; Circadian Rhythm; Floxuridine; Fluorouracil; Humans; Neoplasms; Neoplasms, Experimental; Time Factors | 1995 |
Hepatic artery chemotherapy for colorectal liver metastases.
Topics: Antineoplastic Agents; Colorectal Neoplasms; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Randomized Controlled Trials as Topic | 1995 |
Circadian pharmacodynamics of anticancer therapies.
Topics: Animals; Antineoplastic Agents; Circadian Rhythm; Floxuridine; Fluorouracil; Humans | 1993 |
Hepatic arterial chemotherapy for metastatic colorectal carcinoma.
Topics: Colorectal Neoplasms; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Maleic Anhydrides; Mitomycin; Polystyrenes; Zinostatin | 1994 |
Antimetabolites.
Topics: Antimetabolites, Antineoplastic; Cytarabine; Drug Design; Drug Resistance; Floxuridine; Fluorouracil; Humans; Methotrexate; Purines | 1993 |
Recent advances in the treatment of advanced colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Drug Administration Schedule; Drug Interactions; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Hydroxyurea; Infusions, Intra-Arterial; Leucovorin; Methotrexate; Neoplasm Staging; Phosphonoacetic Acid; Prospective Studies; Randomized Controlled Trials as Topic | 1993 |
Fluoropyrimidine catabolism.
Topics: Animals; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Floxuridine; Fluorouracil; Humans; Neoplasms; Oxidoreductases; Polymorphism, Genetic | 1995 |
Reappraisal of hepatic arterial infusion in the treatment of nonresectable liver metastases from colorectal cancer.
Topics: Antimetabolites, Antineoplastic; Colorectal Neoplasms; Floxuridine; Fluorouracil; Health Care Costs; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms | 1996 |
Biochemical modulation of fluoropyrimidines: is there an optimal (6R,S) leucovorin dose and schedule?
Topics: Animals; Antimetabolites, Antineoplastic; Colonic Neoplasms; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Leucovorin | 1996 |
Preclinical studies of chemotherapy and radiation therapy for pancreatic carcinoma.
Topics: Antimetabolites, Antineoplastic; Bromodeoxyuridine; Combined Modality Therapy; Deoxycytidine; Floxuridine; Fluorouracil; Gemcitabine; Idoxuridine; Pancreatic Neoplasms; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 1996 |
Regional versus systemic chemotherapy in the treatment of colorectal carcinoma metastatic to the liver. Is there a survival difference? Meta-analysis of the published literature.
Topics: Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Survival Rate; Treatment Outcome | 1996 |
Hepatic arterial infusion for metastatic colorectal cancer: the price of "success".
Topics: Antimetabolites, Antineoplastic; Colorectal Neoplasms; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Treatment Outcome | 1996 |
Chemotherapy for the treatment of patients with metastatic colorectal cancer: an overview.
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Quinazolines; Thiophenes; Thymidylate Synthase; Trimetrexate | 1997 |
Chemotherapy of colorectal cancer: history and new themes.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Floxuridine; Fluorouracil; History, 20th Century; Humans; Prodrugs; Uridine | 1997 |
[Treatment strategy for recurrent breast cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Cyclophosphamide; Doxorubicin; Epirubicin; Female; Floxuridine; Fluorouracil; Gonadotropin-Releasing Hormone; Humans; Infusions, Intravenous; Medroxyprogesterone Acetate; Neoplasm Recurrence, Local; Palliative Care; Survival Rate; Tamoxifen | 1998 |
Continuous infusion of chemotherapy: focus on 5-fluorouracil and fluorodeoxyuridine.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous | 1998 |
Comparison of 5-fluoro-2'-deoxyuridine with 5-fluorouracil and their role in the treatment of colorectal cancer.
Topics: Antimetabolites, Antineoplastic; Cell Division; Clinical Trials as Topic; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Tumor Cells, Cultured | 1998 |
Is repeated treatment with a 5-fluorouracil-based regimen useful in colorectal cancer?
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Injections, Intravenous; Irinotecan; Leucovorin; Liver Neoplasms; Organoplatinum Compounds; Oxaliplatin; Randomized Controlled Trials as Topic; Salvage Therapy | 1998 |
Basic research supported developments of chemotherapy in nonresectable isolated colorectal liver metastases to a protocol of hepatic artery infusion using mitoxantrone, 5-FU + folinic acid and mitomycin C.
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colorectal Neoplasms; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Male; Middle Aged; Mitomycin; Mitoxantrone; Randomized Controlled Trials as Topic; Survival Analysis | 1999 |
[Gastrointestinal cancer and oral anticancer agents].
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Agents; Camptothecin; Drug Combinations; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Humans; Irinotecan; Organoplatinum Compounds; Oxonic Acid; Prodrugs; Pyridines; Tegafur; Uracil | 1999 |
[Recent development of oral anti-cancer drugs for breast cancer].
Topics: Administration, Oral; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Clinical Trials, Phase II as Topic; Cyclophosphamide; Drug Administration Schedule; Fadrozole; Female; Floxuridine; Fluorouracil; Gonadotropin-Releasing Hormone; Humans; Medroxyprogesterone Acetate; Survival Rate; Tamoxifen; Toremifene | 1999 |
[Oral fluoropyrimidines in oncology].
Topics: Administration, Oral; Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Clinical Trials as Topic; Combined Modality Therapy; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Male; Neoplasm Recurrence, Local; Neoplasms; Tegafur; Time Factors; Uracil | 1998 |
Survival impact of chemotherapy in patients with colorectal metastases confined to the liver: a re-analysis of 1458 non-operable patients randomised in 22 trials and 4 meta-analyses. Meta-Analysis Group in Cancer.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Evaluation Studies as Topic; Female; Floxuridine; Fluorouracil; Humans; Injections, Intralesional; Liver Neoplasms; Male; Methotrexate; Middle Aged; Palliative Care; Prognosis; Randomized Controlled Trials as Topic; Survival Analysis; Terminally Ill; Treatment Outcome | 1999 |
[New drugs in gastrointestinal oncology. Current status and future directions].
Topics: Antineoplastic Agents; Camptothecin; Capecitabine; Deoxycytidine; Docetaxel; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Gemcitabine; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Quinazolines; Taxoids; Tegafur; Thiophenes; Vinblastine; Vinorelbine | 1999 |
Relevance of locoregional chemotherapy in patients with liver metastases from colorectal primaries.
Topics: Antimetabolites, Antineoplastic; Colorectal Neoplasms; Floxuridine; Fluorouracil; Follow-Up Studies; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Liver Neoplasms; Neoplasm Staging; Randomized Controlled Trials as Topic; Survival Rate; Treatment Outcome | 2000 |
Hepatic arterial chemotherapy for colorectal cancer metastatic to the liver.
Topics: Antimetabolites, Antineoplastic; Colorectal Neoplasms; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Patient Selection | 2000 |
Relation between tumour response to first-line chemotherapy and survival in advanced colorectal cancer: a meta-analysis. Meta-Analysis Group in Cancer.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Floxuridine; Fluorouracil; Leucovorin; Methotrexate; Randomized Controlled Trials as Topic; Survival Analysis; Treatment Outcome | 2000 |
[The role of prophylactic hepatic arterial infusion chemotherapy after potentially curative resection of hepatic metastases from colorectal cancer].
Topics: Antimetabolites, Antineoplastic; Colorectal Neoplasms; Floxuridine; Fluorouracil; Hepatectomy; Hepatic Artery; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Liver Neoplasms; Neoplasm Recurrence, Local; Survival Analysis | 2000 |
[Hepatic arterial infusion chemotherapy for liver metastases from colorectal cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Survival Rate | 2000 |
Therapeutic approaches to metastasis confined to the liver.
Topics: Antimetabolites, Antineoplastic; Chemoembolization, Therapeutic; Chemotherapy, Adjuvant; Colorectal Neoplasms; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms | 2001 |
[Evidence for and practical use of arterial infusion chemotherapy for liver metastases].
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Administration Schedule; Evidence-Based Medicine; Floxuridine; Fluorouracil; Humans; Informed Consent; Infusions, Intra-Arterial; Liver Neoplasms | 2002 |
Intrahepatic arterial infusion of chemotherapy: pharmacologic principles.
Topics: Animals; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Liver Neoplasms | 2002 |
Intrahepatic arterial infusion of chemotherapy: clinical results.
Topics: Antimetabolites, Antineoplastic; Colorectal Neoplasms; Combined Modality Therapy; Floxuridine; Fluorouracil; Hepatectomy; Hepatic Artery; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Liver Neoplasms; Neoplasm Recurrence, Local; Patient Selection; Randomized Controlled Trials as Topic | 2002 |
Thymidylate Synthase expression as a predictor of clinical response to fluoropyrimidine-based chemotherapy in advanced colorectal cancer.
Topics: Colorectal Neoplasms; Cytological Techniques; Drug Resistance, Neoplasm; Floxuridine; Fluorouracil; Humans; In Vitro Techniques; Predictive Value of Tests; Reference Standards; Thymidylate Synthase | 2002 |
The mechanism of action of radiosensitization of conventional chemotherapeutic agents.
Topics: Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Floxuridine; Fluorouracil; Gemcitabine; Humans; Neoplasms; Radiation-Sensitizing Agents; Randomized Controlled Trials as Topic; Risk Factors | 2003 |
Complications of hepatic artery infusion: a review of 4580 reported cases.
Topics: Antimetabolites, Antineoplastic; Arterial Occlusive Diseases; Bone Marrow Diseases; Catheters, Indwelling; Cholangitis, Sclerosing; Colorectal Neoplasms; Digestive System Diseases; Floxuridine; Fluorouracil; Foreign-Body Migration; Hepatic Artery; Hepatitis; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Thrombosis | 2001 |
[The role of the regional (intra-arterial) chemotherapy in the treatment of hepatic metastases of colorectal cancer].
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Carmustine; Colorectal Neoplasms; Cross-Over Studies; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Meta-Analysis as Topic; Mitomycin; Prospective Studies; Randomized Controlled Trials as Topic; Time Factors | 2003 |
Arterial chemotherapy as adjuvant and palliative treatment of hepatic colorectal metastases: an update.
Topics: Antineoplastic Agents; Chemotherapy, Adjuvant; Colorectal Neoplasms; Combined Modality Therapy; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Neoplasm Recurrence, Local; Palliative Care; Randomized Controlled Trials as Topic | 2003 |
BIOCHEMICAL MECHANISMS OF ACTION OF FLUORINATED PYRIMIDINES.
Topics: DNA; DNA, Neoplasm; Floxuridine; Fluorouracil; Ligases; Neoplasms; Pharmacology; Pyrimidines; Research; RNA; RNA, Neoplasm | 1963 |
EXPERIMENTAL AND CLINICAL USE OF FLUORINATED PYRIMIDINES IN CANCER CHEMOTHERAPY.
Topics: Breast Neoplasms; Carbon Isotopes; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Humans; Metabolism; Neoplasms; Neoplasms, Experimental; Pharmacology; Pyrimidines | 1963 |
BIOCHEMISTRY OF CANCER (METABOLIC ASPECTS).
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Azaguanine; Azaserine; Carcinoma, Ehrlich Tumor; DNA; DNA, Neoplasm; Floxuridine; Fluorouracil; Folic Acid; Glutamine; Leukemia L1210; Mercaptopurine; Methotrexate; Mitomycin; Neoplasms; Neoplasms, Experimental; Pharmacology; Purines; Puromycin; Pyrimidines; Research; RNA; RNA, Neoplasm; Thioguanine; Thiouracil | 1963 |
EFFECTS OF GROWTH-INHIBITING CHEMICALS ON THE SAND-DOLLAR EMBRYO, ECHINARACHNIUS PARMA.
Topics: Adenine; Animals; Azaguanine; Bromodeoxyuridine; Colchicine; Dinitrophenols; Echinodermata; Embryo, Mammalian; Embryo, Nonmammalian; Enzyme Inhibitors; Floxuridine; Fluorouracil; Growth; Idoxuridine; Mercaptopurine; Pharmacology; Pyrimidines; Sea Urchins | 1963 |
Review article: colorectal cancer chemotherapy.
Topics: Antineoplastic Agents; Camptothecin; Chemotherapy, Adjuvant; Clinical Trials as Topic; Colorectal Neoplasms; Drug Design; Floxuridine; Fluorouracil; Forecasting; Hepatic Artery; Humans; Infusions, Intra-Arterial; Irinotecan; Liver Neoplasms; Organoplatinum Compounds; Oxaliplatin; Pyrimidines; Quinazolines; Thiophenes | 2003 |
[Doxifluridine for treatment of colorectal cancer].
Topics: Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Floxuridine; Fluorouracil; Humans; Pentosyltransferases; Prodrugs; Prognosis; Pyrimidine Phosphorylases; Thymidine Phosphorylase | 2003 |
Defining the role of hepatic arterial infusion chemotherapy in metastatic colorectal cancer.
Topics: Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Colorectal Neoplasms; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Liver Neoplasms; Neoadjuvant Therapy; Randomized Controlled Trials as Topic | 2004 |
Hepatic arterial infusion chemotherapy for metastatic colorectal cancer: a concise overview.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Combined Modality Therapy; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Randomized Controlled Trials as Topic; Survival Analysis; Treatment Outcome | 2004 |
Uridine phosophorylase: an important enzyme in pyrimidine metabolism and fluoropyrimidine activation.
Topics: Animals; Antimetabolites, Antineoplastic; Floxuridine; Fluorouracil; Gene Expression Regulation, Enzymologic; Humans; Neoplasms; Pyrimidines; Uridine; Uridine Phosphorylase | 2004 |
Role of DNA mismatch repair in apoptotic responses to therapeutic agents.
Topics: Alkylating Agents; Antineoplastic Agents; Apoptosis; Base Pair Mismatch; Camptothecin; Cisplatin; DNA Adducts; DNA Repair; Floxuridine; Fluorouracil; Guanine Nucleotides; HCT116 Cells; Humans; Irinotecan; Radiation, Ionizing; Thionucleotides | 2004 |
[Effectiveness of chemoradiotherapy for three cases of squamous cell anal carcinoma].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Anus Neoplasms; Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Female; Floxuridine; Fluorouracil; Humans; Lymphatic Metastasis; Middle Aged; Radiotherapy, Adjuvant; Tegafur; Uracil | 2004 |
[Current combination chemotherapy containing paclitaxel for advanced, recurrent gastric cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Drug Combinations; Floxuridine; Fluorouracil; Humans; Oxonic Acid; Paclitaxel; Pyridines; Quality of Life; Stomach Neoplasms; Tegafur | 2004 |
Dihydropyrimidine dehydrogenase deficiency: impact of pharmacogenetics on 5-fluorouracil therapy.
Topics: Antidotes; Antimetabolites, Antineoplastic; Biotransformation; Deoxyuracil Nucleotides; Diarrhea; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); DNA Mutational Analysis; Drug Eruptions; Fever; Floxuridine; Fluorouracil; Humans; Inactivation, Metabolic; Mass Screening; Mucositis; Mutation; Prodrugs; Pyrimidine Nucleosides; Thymidylate Synthase; Uridine Triphosphate | 2004 |
Uridine phosphorylase in breast cancer: a new prognostic factor?
Topics: Animals; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Breast Neoplasms; Capecitabine; Deoxycytidine; Enzyme Induction; Female; Floxuridine; Fluorouracil; Gene Expression Regulation; Humans; Mice; Prodrugs; Prognosis; Pyrimidinones; Treatment Outcome; Uridine Phosphorylase | 2006 |
Emerging efficacy endpoints for targeted therapies in advanced renal cell carcinoma.
Topics: Antimetabolites, Antineoplastic; Benzenesulfonates; Carcinoma, Renal Cell; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Disease Progression; Drug Delivery Systems; Endpoint Determination; Floxuridine; Fluorouracil; Humans; Kidney Neoplasms; Niacinamide; Phenylurea Compounds; Pyridines; Risk; Sorafenib; Survival Analysis; Treatment Outcome | 2006 |
A phase II study of irinotecan in combination with doxifluridine, an intermediate form of capecitabine, in patients with metastatic colorectal cancer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Female; Floxuridine; Fluorouracil; Follow-Up Studies; Hematologic Diseases; Humans; Irinotecan; Leukocyte Count; Male; Middle Aged; Neoplasm Metastasis; Sample Size; Survival Analysis | 2008 |
[Current therapeutic options for liver metastasis].
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma; Catheter Ablation; Colorectal Neoplasms; Combined Modality Therapy; Cryosurgery; Floxuridine; Fluorouracil; Hepatectomy; Humans; Irinotecan; Liver Neoplasms; Neoplasm Staging; Prognosis; Survival Rate; Time Factors | 2008 |
Regional chemotherapy for liver-limited metastatic colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Colorectal Neoplasms; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Irinotecan; Leucovorin; Liver Neoplasms; Mitomycin; Neoadjuvant Therapy; Organoplatinum Compounds; Oxaliplatin | 2008 |
Patterns of chemotherapy-induced hepatic injury and their implications for patients undergoing liver resection for colorectal liver metastases.
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Combined Modality Therapy; Fatty Liver; Floxuridine; Fluorouracil; Hepatectomy; Hepatic Veno-Occlusive Disease; Humans; Irinotecan; Leucovorin; Liver; Liver Neoplasms; Neoadjuvant Therapy; Organoplatinum Compounds; Oxaliplatin; Risk Factors | 2009 |
The role of floxuridine in metastatic liver disease.
Topics: Antineoplastic Agents; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver; Liver Neoplasms; Neoadjuvant Therapy; Survival Analysis | 2009 |
Fluoropyrimidine-HAI (hepatic arterial infusion) versus systemic chemotherapy (SCT) for unresectable liver metastases from colorectal cancer.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Randomized Controlled Trials as Topic | 2009 |
Selective internal radiation therapy for liver metastases from colorectal cancer.
Topics: Antimetabolites, Antineoplastic; Colorectal Neoplasms; Combined Modality Therapy; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Microspheres; Radiotherapy; Randomized Controlled Trials as Topic; Yttrium Radioisotopes | 2009 |
Therapeutic usefulness of postoperative adjuvant chemotherapy with Tegafur-Uracil (UFT) in patients with breast cancer: focus on the results of clinical studies in Japan.
Topics: Administration, Oral; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Chemotherapy, Adjuvant; Cisplatin; Clinical Trials as Topic; Deoxycytidine; Drug Combinations; Female; Floxuridine; Fluorouracil; Humans; Japan; Methotrexate; Oxonic Acid; Tegafur; Uracil | 2010 |
Chemotherapy for the conversion of unresectable colorectal cancer liver metastases to resection.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biological Therapy; Camptothecin; Chemotherapy, Adjuvant; Colorectal Neoplasms; Floxuridine; Fluorouracil; Hepatectomy; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Organoplatinum Compounds; Survival Analysis; Treatment Outcome | 2011 |
Oral versus intravenous fluoropyrimidines for colorectal cancer.
Topics: Administration, Oral; Adult; Antineoplastic Agents; Camptothecin; Capecitabine; Chemotherapy, Adjuvant; Colorectal Neoplasms; Disease-Free Survival; Female; Floxuridine; Fluorouracil; Humans; Injections, Intravenous; Irinotecan; Male; Neoadjuvant Therapy; Organoplatinum Compounds; Palliative Care; Pyridines; Pyrimidines; Randomized Controlled Trials as Topic; Tegafur; Uracil | 2017 |
83 trial(s) available for fluorouracil and floxuridine
| Article | Year |
|---|---|
Hepatic artery infusion of 5-FUDR after prior systemic 5-fluorouracil.
Topics: Adult; Aged; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Injections, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Neoplasm Metastasis | 1976 |
Preoperative systemic chemotherapy followed by adjuvant postoperative intraperitoneal therapy for gastric cancer: a University of Southern California pilot program.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Drug Administration Schedule; Feasibility Studies; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Infusions, Parenteral; Leucovorin; Male; Middle Aged; Pilot Projects; Stomach Neoplasms; Survival Analysis; Treatment Outcome | 1992 |
Continuous regional treatment with fluoropyrimidines for metastases from colorectal carcinomas: influence of modulation with leucovorin.
Topics: Colorectal Neoplasms; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusion Pumps; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Male | 1992 |
Is hepatic infusion of chemotherapy effective treatment for liver metastases? Yes!
Topics: Actuarial Analysis; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Dexamethasone; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusion Pumps; Infusions, Intra-Arterial; Infusions, Intravenous; Liver Diseases; Liver Neoplasms; Quality of Life; Retrospective Studies; Survival Analysis | 1992 |
Is hepatic infusion of chemotherapy effective treatment for liver metastases? No!
Topics: Antineoplastic Agents; Colorectal Neoplasms; Floxuridine; Fluorouracil; Forecasting; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Injections, Intravenous; Leucovorin; Liver Neoplasms; Mitomycin; Survival Rate | 1992 |
Alternating hepatic intra-arterial floxuridine and fluorouracil: a less toxic regimen for treatment of liver metastases from colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Evaluation; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Injections, Intra-Arterial; Liver Neoplasms; Male; Middle Aged | 1991 |
Two consecutive clinical trials on cisplatin (CDDP), hepatic arterial infusion (HAI), and i.v. 5-fluorouracil (5-FU) chemotherapy for unresectable colorectal liver metastases: an alternative to FUdR-based regimens?
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Evaluation; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Middle Aged; Organoplatinum Compounds; Survival Rate | 1991 |
Intra-arterial floxuridine vs systemic fluorouracil for hepatic metastases from colorectal cancer. A randomized trial.
Topics: Adenocarcinoma; Aged; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Injections, Intravenous; Liver Neoplasms; Male; Middle Aged; Multicenter Studies as Topic; Prospective Studies; Randomized Controlled Trials as Topic; Survival Rate | 1990 |
[Requirements for the randomized trial of i.a. vs. i.v. administration to reveal the impact of hepatic arterial infusion on survival in the treatment of liver metastases].
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Randomized Controlled Trials as Topic; Stomach Neoplasms; Survival Rate | 1990 |
Cancer chronotherapy: a drug delivery challenge.
Topics: Animals; Antineoplastic Agents; Carcinoma, Renal Cell; Circadian Rhythm; Colorectal Neoplasms; Drug Administration Schedule; Drug Tolerance; Female; Floxuridine; Fluorouracil; Humans; Kidney Neoplasms; Liver Neoplasms; Mice; Neoplasms; Ovarian Neoplasms | 1990 |
A prospective, randomized evaluation of the treatment of colorectal cancer metastatic to the liver.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Combined Modality Therapy; Evaluation Studies as Topic; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Liver Neoplasms; Male; Middle Aged; Neoplasm Staging; Survival Rate | 1990 |
[Is there a primary indication for regional therapy of liver metastases of gastrointestinal tumors?].
Topics: Antineoplastic Agents; Clinical Trials as Topic; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Infusion Pumps; Infusions, Intra-Arterial; Liver Neoplasms; Prospective Studies; Random Allocation | 1989 |
Value of in vivo tissue testing in predicting the clinical response to regional perfusion chemotherapy in colorectal cancer patients with liver metastases.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Infusion Pumps; Liver Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Transplantation, Heterologous | 1989 |
[Regional chemotherapy of liver metastases in colorectal carcinoma. Intra-arterial vs intravenous plus intra-arterial therapy].
Topics: Adult; Aged; Colorectal Neoplasms; Combined Modality Therapy; Evaluation Studies as Topic; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Liver Neoplasms; Male; Middle Aged; Mitomycins; Postoperative Care | 1989 |
Prevention of extrahepatic disease during intraarterial floxuridine of colorectal liver metastases by simultaneous systemic 5-fluorouracil treatment? A prospective multicenter study.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Colorectal Neoplasms; Floxuridine; Fluorouracil; Germany, West; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Infusions, Intravenous; Liver Neoplasms; Middle Aged; Multicenter Studies as Topic; Neoplasm Metastasis; Prospective Studies; Random Allocation; Remission Induction; Survival Rate | 1989 |
[European topic: liver surgery II--regional chemotherapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Combined Modality Therapy; Floxuridine; Fluorouracil; Humans; Infusion Pumps; Infusions, Intra-Arterial; Liver Neoplasms; Mitomycin | 1989 |
Systemic infusional chemotherapy for liver metastasis: an improved schedule for 5-fluorouracil.
Topics: Clinical Trials as Topic; Colonic Neoplasms; Drug Administration Schedule; Floxuridine; Fluorouracil; Follow-Up Studies; Humans; Infusions, Parenteral; Liver Neoplasms; Rectal Neoplasms | 1986 |
A Northern California Oncology Group randomized trial of leucovorin plus 5-fluorouracil versus sequential methotrexate, 5-fluorouracil, and leucovorin in patients with advanced colorectal cancer who failed treatment with 5-fluorouracil or 5-fluorodeoxyuri
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Colonic Neoplasms; Drug Administration Schedule; Drug Resistance; Floxuridine; Fluorouracil; Humans; Leucovorin; Methotrexate; Rectal Neoplasms | 1987 |
Continuous infusion fluoropyrimidines as salvage therapy for patients with advanced ovarian carcinoma.
Topics: Adult; Aged; Cyclophosphamide; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Middle Aged; Neoplasm Recurrence, Local; Ovarian Neoplasms | 1988 |
A randomized comparison of doxifluridine and fluorouracil in colorectal carcinoma.
Topics: Adenocarcinoma; Antineoplastic Agents; Clinical Trials as Topic; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Random Allocation; Rectal Neoplasms | 1988 |
Regional infusion of fluoropyrimidines for hepatic metastases of colorectal cancer.
Topics: Clinical Trials as Topic; Colonic Neoplasms; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusion Pumps; Infusions, Intra-Arterial; Liver Neoplasms; Portal System; Rectal Neoplasms | 1988 |
Cytostatic drug therapy in disseminated colorectal cancer.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Leucovorin; Methotrexate; Semustine; Vincristine | 1988 |
The pharmacokinetics of doxifluridine and 5-fluorouracil after single intravenous infusions of doxifluridine to patients with colorectal cancer.
Topics: Adult; Aged; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Half-Life; Humans; Infusions, Intravenous; Male; Middle Aged | 1988 |
Fluorinated pyrimidines.
Topics: Animals; Carcinoma, Ehrlich Tumor; Clinical Trials as Topic; DNA; DNA Viruses; Enzyme Induction; Floxuridine; Fluorouracil; Humans; Ligases; Protein Biosynthesis; RNA Viruses | 1965 |
Adrenal function in patients treated with testosterone and fluorinated pyrimidines.
Topics: 17-Ketosteroids; Adenocarcinoma; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Aged; Breast Neoplasms; Clinical Trials as Topic; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Pituitary-Adrenal Function Tests; Rectal Neoplasms; Sertoli-Leydig Cell Tumor; Stomach Neoplasms; Testosterone | 1968 |
Adjuvant chemotherapy of large bowel cancer.
Topics: Antineoplastic Agents; Clinical Trials as Topic; Colonic Neoplasms; Drug Therapy, Combination; Floxuridine; Fluorouracil; Humans; Lymphatic Metastasis; Mechlorethamine; Palliative Care; Random Allocation; Rectal Neoplasms; Thiotepa | 1982 |
Chemotherapy of large bowel cancer.
Topics: Antineoplastic Agents; Clinical Trials as Topic; Drug Therapy, Combination; Floxuridine; Fluorouracil; Follow-Up Studies; Humans; Intestinal Neoplasms; Liver Neoplasms; Semustine; Tegafur; Vincristine | 1982 |
[Chrono-chemotherapy and dose intensity].
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chronobiology Phenomena; Circadian Rhythm; Cisplatin; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Infusion Pumps; Interferon-alpha; Leucovorin; Male; Mice; Neoplasms; Neoplasms, Experimental; Organoplatinum Compounds; Ovarian Neoplasms; Oxaliplatin; Rats | 1995 |
Suramin in patients with metastatic colorectal cancer pretreated with fluoropyrimidine-based chemotherapy. A phase II study.
Topics: Adult; Aged; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Metastasis; Suramin; Treatment Outcome | 1995 |
[5-FU concentrations in the blood and tumor tissue after 5'-DFUR or UFT administration in the patients with uterine cervical cancer].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Female; Floxuridine; Fluorouracil; Humans; Lymph Nodes; Middle Aged; Tegafur; Uracil; Uterine Cervical Neoplasms | 1995 |
[Pharmacological study of 5'-DFUR oral administration and the clinical responses against gastrointestinal carcinoma].
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Pancreatic Neoplasms; Stomach Neoplasms; Treatment Outcome | 1995 |
A phase I trial of immediate postoperative intraperitoneal floxuridine and leucovorin plus systemic 5-fluorouracil and levamisole after resection of high risk colon cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Combined Modality Therapy; Female; Floxuridine; Fluorouracil; Humans; Infusions, Parenteral; Leucovorin; Levamisole; Male; Middle Aged; Neoplasm Recurrence, Local; Postoperative Period; Survival Analysis | 1994 |
[Hepatic arterial infusion after hepatectomy for liver metastases of colorectal carcinoma to prevent residual hepatic recurrence].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Hepatectomy; Hepatic Artery; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm, Residual; Prognosis | 1994 |
[A study of preoperative administration of 5'-DFUR in patients with colo-rectal cancer].
Topics: Administration, Oral; Antineoplastic Agents; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Lymph Nodes; Lymphatic Metastasis; Pentosyltransferases; Preoperative Care; Pyrimidine Phosphorylases | 1994 |
[Randomized controlled study of sequential methotrexate and 5-fluorouracil therapy with or without 5'-deoxy-5-fluorouridine against advanced gastrointestinal cancer. Hirosaki Cooperative Study Group for Cancer Chemotherapy].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Quality of Life; Survival Analysis | 1994 |
[Sequential methotrexate/5-fluorouracil therapy with 5'-deoxy-5-fluorouridine against advanced gastric cancer: comparison between bolus injection and drip infusion of 5-fluorouracil administration. Hirosaki Cooperative Study Group for Cancer Chemotherapy]
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Alopecia; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Injections, Intravenous; Leukopenia; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Stomach Neoplasms | 1994 |
Prospective randomised trial comparing fluorouracil versus doxifluridine for the treatment of advanced colorectal cancer.
Topics: Adult; Aged; Antineoplastic Agents; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Leukopenia; Male; Middle Aged; Prospective Studies | 1993 |
A pilot study of hepatic artery floxuridine combined with systemic 5-fluorouracil and leucovorin. A potential adjuvant program after resection of colorectal hepatic metastases.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Male; Middle Aged; Pilot Projects; Survival Rate | 1993 |
Systemic chemotherapy for gastric carcinoma followed by postoperative intraperitoneal therapy: a final report.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Infusions, Parenteral; Leucovorin; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Stomach Neoplasms; Tomography, X-Ray Computed | 1997 |
Effect of regional and systemic fluorinated pyrimidine chemotherapy on quality of life in colorectal liver metastasis patients.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Middle Aged; Pain Measurement; Quality of Life; Survival Analysis | 1997 |
Doxifluridine in colorectal cancer patients resistant to 5-fluorouracil (5-FU) containing regimens.
Topics: Administration, Oral; Adult; Aged; Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Agents; Colorectal Neoplasms; Drug Resistance, Neoplasm; Drug Therapy, Combination; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Tomography, X-Ray Computed | 1997 |
Thymidylate synthase is a predictor for response and resistance in hepatic artery infusion chemotherapy.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Colorectal Neoplasms; Drug Administration Schedule; Drug Resistance, Neoplasm; Epirubicin; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Male; Middle Aged; Mitoxantrone; Polymerase Chain Reaction; Predictive Value of Tests; Prognosis; RNA, Messenger; Survival Rate; Thymidylate Synthase; Transcription, Genetic | 1997 |
Sequential intrahepatic fluorodeoxyuridine and systemic fluorouracil plus leucovorin for the treatment of metastatic colorectal cancer confined to the liver.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease-Free Survival; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Leucovorin; Liver Neoplasms; Male; Middle Aged; Treatment Outcome | 1998 |
Oral doxifluridine plus levoleucovorin in elderly patients with advanced breast cancer.
Topics: Administration, Oral; Aged; Aged, 80 and over; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Methotrexate; Neoplasm Staging | 1998 |
Hepatic arterial floxuridine as second-line treatment for systemic fluorouracil-resistant colorectal liver metastases.
Topics: Colorectal Neoplasms; Drug Resistance, Neoplasm; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Injections, Intra-Arterial; Liver Neoplasms; Middle Aged; Quality of Life; Survival Rate; Time Factors; Treatment Outcome | 1998 |
[Intra-arterial (5-FU/FA and FUDR) versus systemic chemotherapy (5-FU/FA) of non-resectable colorectal liver metastases].
Topics: Adult; Aged; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Leucovorin; Liver Neoplasms; Male; Middle Aged; Prospective Studies; Survival Rate; Treatment Outcome | 1998 |
Continuous delivery of venous 5-fluorouracil and arterial 5-fluorodeoxyuridine for hepatic metastases from colorectal cancer: feasibility and tolerance in a randomized phase II trial comparing flat versus chronomodulated infusion.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biological Clocks; Colonic Neoplasms; Colorectal Neoplasms; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Liver Neoplasms; Male; Middle Aged; Rectal Neoplasms; Stomatitis | 1999 |
Hepatic arterial infusion of chemotherapy after resection of hepatic metastases from colorectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Combined Modality Therapy; Dexamethasone; Disease-Free Survival; Equipment Failure; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Infusions, Intravenous; Leucovorin; Liver Neoplasms; Male; Middle Aged; Survival Rate | 1999 |
Randomized, multicenter trial of fluorouracil plus leucovorin administered either via hepatic arterial or intravenous infusion versus fluorodeoxyuridine administered via hepatic arterial infusion in patients with nonresectable liver metastases from colore
Topics: Adenocarcinoma; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Catheters, Indwelling; Colonic Neoplasms; Disease Progression; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Leucovorin; Liver Neoplasms; Male; Middle Aged; Rectal Neoplasms; Survival Analysis; Treatment Outcome | 2000 |
Selective augmentations of intratumoral 5-fluorouracil concentration by local immunotherapy with OK-432 and fibrinogen.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Chemotherapy, Adjuvant; Colon; Colorectal Neoplasms; Combined Modality Therapy; Drug Synergism; Female; Fibrinogen; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Neoadjuvant Therapy; Picibanil; Rectum | 2000 |
A phase III randomized study comparing oral doxifluridine and oral 5-fluorouracil after curative resection of gastric cancer.
Topics: Administration, Oral; Adult; Aged; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Stomach Neoplasms; Time Factors | 2000 |
A prospective randomized trial comparing intravenous 5-fluorouracil and oral doxifluridine as postoperative adjuvant treatment for advanced rectal cancer.
Topics: Adenocarcinoma; Administration, Oral; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Disease-Free Survival; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasm Recurrence, Local; Postoperative Period; Prospective Studies; Quality of Life; Rectal Neoplasms; Treatment Outcome | 2000 |
Intravenous 5-fluorouracil versus oral doxifluridine as preoperative concurrent chemoradiation for locally advanced rectal cancer: prospective randomized trials.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Combined Modality Therapy; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Prospective Studies; Quality of Life; Rectal Neoplasms | 2001 |
Variations in 5-fluorouracil concentrations of colorectal tissues as compared with dihydropyrimidine dehydrogenase (DPD) enzyme activities and DPD messenger RNA levels.
Topics: Antimetabolites, Antineoplastic; Colon; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Oxidoreductases; Rectum; RNA, Messenger | 2001 |
Combined-modality treatment for resectable metastatic colorectal carcinoma to the liver: surgical resection of hepatic metastases in combination with continuous infusion of chemotherapy--an intergroup study.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Combined Modality Therapy; Disease-Free Survival; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Liver Neoplasms; Logistic Models; Male; Neoplasm Recurrence, Local; Survival Rate; Treatment Outcome | 2002 |
Preoperative chemoradiation in patients with resectable rectal cancer: results on tumor response.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Rectal Neoplasms; Treatment Outcome | 2002 |
Systemic irinotecan or regional floxuridine chemotherapy prolongs survival after hepatic cryosurgery in patients with metastatic colon cancer refractory to 5-fluorouracil.
Topics: Antimetabolites, Antineoplastic; Camptothecin; Chemotherapy, Adjuvant; Chemotherapy, Cancer, Regional Perfusion; Colorectal Neoplasms; Cryosurgery; Disease-Free Survival; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Irinotecan; Liver Neoplasms; Neoplasm Recurrence, Local; Prodrugs; Survival Analysis; Tomography, X-Ray Computed; Topoisomerase I Inhibitors; Treatment Outcome | 2001 |
Oral doxifluridine plus leucovorin in metastatic colorectal cancer: randomized phase II trial with intravenous 5-fluorouracil plus leucovorin.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Survival Analysis | 2003 |
Population pharmacokinetics and concentration-effect relationships of capecitabine metabolites in colorectal cancer patients.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; beta-Alanine; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Male; Middle Aged | 2003 |
A randomized controlled trial of postoperative adjuvant immunochemotherapy for colorectal cancer with oral medicines.
Topics: Adjuvants, Immunologic; Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Immunosuppressive Agents; Lymphatic Metastasis; Male; Middle Aged; Prognosis; Recurrence; Time Factors; Treatment Outcome | 2003 |
Plasma concentrations of 5-fluorouracil and its metabolites in colon cancer patients.
Topics: Adult; Aged; Area Under Curve; Chromatography, High Pressure Liquid; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Injections, Intravenous; Kinetics; Leucovorin; Male; Middle Aged; Uridine | 2004 |
Important role of the dihydrouracil/uracil ratio in marked interpatient variations of fluoropyrimidine pharmacokinetics and pharmacodynamics.
Topics: Adult; Antimetabolites, Antineoplastic; Chorionic Gonadotropin; Female; Floxuridine; Fluorouracil; Gestational Trophoblastic Disease; Humans; Leukocyte Count; Metabolic Clearance Rate; Neutrophils; Prodrugs; Prospective Studies; Uracil | 2004 |
Gene expression profiles of colorectal carcinoma in response to neo-adjuvant chemotherapy.
Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma; Chemotherapy, Adjuvant; Colorectal Neoplasms; Drug Interactions; Female; Floxuridine; Fluorouracil; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, fos; Humans; Infusions, Intravenous; Irinotecan; Male; Middle Aged; Neoadjuvant Therapy; Treatment Outcome; Up-Regulation | 2004 |
Pharmacokinetic and pharmacodynamic comparison of fluoropyrimidine derivatives, capecitabine and 5'-deoxy-5-fluorouridine (5'-DFUR).
Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Area Under Curve; Breast Neoplasms; Capecitabine; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Middle Aged | 2005 |
Improved hepatic toxicity profile of portal vein adjuvant hepatic infusional chemotherapy.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Liver Neoplasms; Male; Middle Aged; Portal Vein | 2005 |
Pharmacokinetic modelling of 5-FU production from capecitabine--a population study in 40 adult patients with metastatic cancer.
Topics: Adult; Aged; Algorithms; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Camptothecin; Capecitabine; Chromatography, High Pressure Liquid; Deoxycytidine; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Humans; Irinotecan; Middle Aged; Models, Biological; Molecular Structure; Neoplasm Metastasis; Neoplasms; Prodrugs; Sesquiterpenes | 2005 |
A phase II trial of neoadjuvant cisplatin-fluorouracil followed by postoperative intraperitoneal floxuridine-leucovorin in patients with locally advanced gastric cancer.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Disease-Free Survival; Endoscopy, Digestive System; Feasibility Studies; Female; Floxuridine; Fluorouracil; Humans; Injections, Intraperitoneal; Leucovorin; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Postoperative Period; Quality of Life; Stomach Neoplasms; Survival Analysis; Treatment Failure | 2006 |
A phase II study of irinotecan in combination with doxifluridine, an intermediate form of capecitabine, in patients with metastatic colorectal cancer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Female; Floxuridine; Fluorouracil; Follow-Up Studies; Hematologic Diseases; Humans; Irinotecan; Leukocyte Count; Male; Middle Aged; Neoplasm Metastasis; Sample Size; Survival Analysis | 2008 |
Concentrations of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU).
Topics: Antineoplastic Agents; Chromatography, High Pressure Liquid; Deoxycytidine; DNA Modification Methylases; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Reproducibility of Results; Tandem Mass Spectrometry; Tetrahydrouridine; Uridine | 2008 |
A phase I safety, tolerability, and pharmacokinetic study of enzastaurin combined with capecitabine in patients with advanced solid tumors.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Capecitabine; Cohort Studies; Deoxycytidine; Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Follow-Up Studies; Humans; Indoles; Male; Middle Aged; Monocytes; Neoplasms; Phosphorylation; Protein Kinase C; Protein Kinase C beta | 2008 |
Phase I trial of adjuvant hepatic arterial infusion (HAI) with floxuridine (FUDR) and dexamethasone plus systemic oxaliplatin, 5-fluorouracil and leucovorin in patients with resected liver metastases from colorectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cohort Studies; Colorectal Neoplasms; Disease-Free Survival; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Survival Rate; Treatment Outcome; Vitamin B Complex | 2009 |
Alternating systemic and hepatic artery infusion therapy for resected liver metastases from colorectal cancer: a North Central Cancer Treatment Group (NCCTG)/ National Surgical Adjuvant Breast and Bowel Project (NSABP) phase II intergroup trial, N9945/CI-
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Catheter Ablation; Chemotherapy, Adjuvant; Colorectal Neoplasms; Cryosurgery; Deoxycytidine; Dexamethasone; Drug Administration Schedule; Feasibility Studies; Female; Floxuridine; Fluorouracil; Hepatectomy; Hepatic Artery; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Kaplan-Meier Estimate; Liver Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Proportional Hazards Models; Risk Assessment; Time Factors; Treatment Outcome; United States | 2010 |
Plasma disposition of capecitabine and its metabolites 5'DFCR and 5'DFUR in a standard and dose-intensified monotherapy regimen.
Topics: Aged; Antimetabolites, Antineoplastic; Area Under Curve; Capecitabine; Colorectal Neoplasms; Cross-Over Studies; Deoxycytidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged | 2011 |
Hepatic arterial infusion and systemic chemotherapy after multiple metastasectomy in patients with colorectal carcinoma metastatic to the liver: a North Central Cancer Treatment Group (NCCTG) phase II study, 92-46-52.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Combined Modality Therapy; Cryosurgery; Female; Floxuridine; Fluorouracil; Follow-Up Studies; Hepatic Artery; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Lymphatic Metastasis; Male; Metastasectomy; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Survival Rate; Treatment Outcome | 2012 |
Higher capecitabine AUC in elderly patients with advanced colorectal cancer (SWOGS0030).
Topics: Age Factors; Aged; Antimetabolites, Antineoplastic; Area Under Curve; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Female; Floxuridine; Fluorouracil; Glomerular Filtration Rate; Humans; Male; Metabolic Clearance Rate; Middle Aged; Sex Factors | 2013 |
Phase II trial of hepatic artery infusional and systemic chemotherapy for patients with unresectable hepatic metastases from colorectal cancer: conversion to resection and long-term outcomes.
Topics: Adult; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Chemotherapy, Adjuvant; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Follow-Up Studies; Hepatectomy; Hepatic Artery; Humans; Infusions, Intra-Arterial; Irinotecan; Liver Neoplasms; Male; Middle Aged; Multivariate Analysis; Neoadjuvant Therapy; Organoplatinum Compounds; Oxaliplatin; Prospective Studies; Survival Analysis; Treatment Outcome | 2015 |
Phase I trial of hepatic arterial infusion (HAI) of floxuridine with modified oxaliplatin, 5-fluorouracil and leucovorin (m-FOLFOX6) in Chinese patients with unresectable liver metastases from colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asian People; China; Colorectal Neoplasms; Diarrhea; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Male; Middle Aged; Neutropenia; Organoplatinum Compounds; Oxaliplatin; Survival Analysis; Treatment Outcome; Young Adult | 2014 |
Simultaneous determination of capecitabine and its three nucleoside metabolites in human plasma by high performance liquid chromatography-tandem mass spectrometry.
Topics: Antimetabolites, Antineoplastic; Capecitabine; Chromatography, High Pressure Liquid; Deoxycytidine; Floxuridine; Fluorouracil; Humans; Male; Neoplasms; Tandem Mass Spectrometry; Therapeutic Equivalency | 2015 |
Pharmacokinetics and pharmacogenetics of capecitabine and its metabolites following replicate administration of two 500 mg tablet formulations.
Topics: Activation, Metabolic; Administration, Oral; Adult; Aged; Alleles; Antimetabolites, Antineoplastic; Area Under Curve; Capecitabine; Carboxylesterase; Cytidine Deaminase; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Female; Floxuridine; Fluorouracil; Genotype; Humans; Liver; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Neoplasm Proteins; Polymorphism, Single Nucleotide; Prodrugs; Tablets; Therapeutic Equivalency; Thymidine Phosphorylase; Thymidylate Synthase | 2015 |
Randomized Controlled Trial of Intraportal Chemotherapy Combined With Adjuvant Chemotherapy (mFOLFOX6) for Stage II and III Colon Cancer.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Chemotherapy, Adjuvant; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Survival Rate; Tomography, X-Ray Computed; Treatment Outcome | 2016 |
Randomized Controlled Trial of Adjuvant Chemotherapy with Fluoropyrimidines
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Staging; Stomach Neoplasms; Survival Analysis; Tegafur; Uracil | 2017 |
A Randomized Phase II Trial of Adjuvant Hepatic Arterial Infusion and Systemic Therapy With or Without Panitumumab After Hepatic Resection of KRAS Wild-type Colorectal Cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Leucovorin; Male; Middle Aged; Panitumumab; Proto-Oncogene Proteins p21(ras) | 2021 |
Prospective phase II trial of combination hepatic artery infusion and systemic chemotherapy for unresectable colorectal liver metastases: Long term results and curative potential.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colorectal Neoplasms; Deoxyuridine; Disease-Free Survival; Female; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Irinotecan; Leucovorin; Liver Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Prospective Studies; Survival Rate; Treatment Outcome | 2018 |
656 other study(ies) available for fluorouracil and floxuridine
| Article | Year |
|---|---|
Synthesis and biological activities of some uronic acids, uronates, uronamides, and urononitriles of pyrimidine nucleosides.
Topics: Animals; Cell Division; Cells, Cultured; Chick Embryo; Pyrimidine Nucleosides; Sarcoma 180; Simplexvirus; Streptococcus; Structure-Activity Relationship; Substrate Specificity; Thymidine Kinase; Thymidylate Synthase; Uronic Acids; Virus Replication | 1978 |
Synthesis and antitumor activity of a series of ftorafur analogues: the effect of varying electronegativity at the 1'-position.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Female; Fluorouracil; Leukemia L1210; Leukemia P388; Mice; Tegafur | 1985 |
Fluorinated pyrimidine nucleosides. 4. Synthesis and antitumor testing of a series of 2',5'-dideoxy- and 2',3',5'-trideoxynucleosides of 5-fluorouracil.
Topics: Animals; Antineoplastic Agents; Deoxyuridine; Floxuridine; Fluorouracil; Mice; Sarcoma 180; Tegafur | 1980 |
5'-[4-(Pivaloyloxy)-1,3,2-dioxaphosphorinan-2-yl]-2'-deoxy-5-fluorouridine: a membrane-permeating prodrug of 5-fluoro-2'-deoxyuridylic acid (FdUMP).
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Cell Membrane; CHO Cells; Cricetinae; Esterases; Fluorodeoxyuridylate; Leukemia P388; Male; Mice; Phosphoric Monoester Hydrolases; Prodrugs; Swine | 1995 |
Synthesis and antitumor evaluation of bis[(pivaloyloxy)methyl] 2'-deoxy-5-fluorouridine 5'-monophosphate (FdUMP): a strategy to introduce nucleotides into cells.
Topics: Animals; Antineoplastic Agents; Carboxylesterase; Carboxylic Ester Hydrolases; Cell Division; CHO Cells; Cricetinae; Drug Screening Assays, Antitumor; Drug Stability; Fluorodeoxyuridylate; Leukemia P388; Mice; Phosphoric Monoester Hydrolases; Prodrugs | 1994 |
Synthesis of 2'-deoxyuridine and 5-fluoro-2'-deoxyuridine derivatives and evaluation in antibody targeting studies.
Topics: Antibodies, Monoclonal; Antibodies, Neoplasm; Antimetabolites, Antineoplastic; Deoxyuridine; Drug Screening Assays, Antitumor; Floxuridine; Humans; Serum Albumin; Tumor Cells, Cultured | 1993 |
Synthesis and antitumor activities of novel pyrimidine derivatives of 2,3-O,O-dibenzyl-6-deoxy-L-ascorbic acid and 4,5-didehydro-5,6- dideoxy-L-ascorbic acid.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Ascorbic Acid; Cell Line; Crystallography, X-Ray; Cytomegalovirus; Drug Screening Assays, Antitumor; Fluorouracil; Herpesvirus 3, Human; HIV; Humans; Magnetic Resonance Spectroscopy; Mice; Models, Molecular; Pyrimidines; Structure-Activity Relationship; Tumor Cells, Cultured | 2000 |
Synthesis and biological studies of novel nucleoside phosphoramidate prodrugs.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Floxuridine; Fluorodeoxyuridylate; Magnetic Resonance Spectroscopy; Mice; Prodrugs; Thymidine Kinase; Thymidylate Synthase; Tumor Cells, Cultured; Uridine Monophosphate | 2001 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Probing the anticancer activity of nucleoside analogues: a QSAR model approach using an internally consistent training set.
Topics: Algorithms; Antineoplastic Agents; Databases, Factual; Discriminant Analysis; Models, Molecular; Nucleosides; Quantitative Structure-Activity Relationship | 2007 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Drug efflux transporter multidrug resistance-associated protein 5 affects sensitivity of pancreatic cancer cell lines to the nucleoside anticancer drug 5-fluorouracil.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluorouracil; Gene Knockdown Techniques; Humans; Multidrug Resistance-Associated Proteins; Pancreas; Pancreatic Neoplasms; RNA; RNA Interference; Tumor Cells, Cultured | 2011 |
Synthesis and biological evaluation of unsaturated keto and exomethylene D-arabinopyranonucleoside analogs: novel 5-fluorouracil analogs that target thymidylate synthase.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cell Line, Tumor; Enzyme Inhibitors; Fluorouracil; Humans; Inhibitory Concentration 50; Mice; Nucleosides; Substrate Specificity; Thymidylate Synthase; Uridine Phosphorylase; Viruses | 2011 |
Phosphoramidate ProTides of the anticancer agent FUDR successfully deliver the preformed bioactive monophosphate in cells and confer advantage over the parent nucleoside.
Topics: Antineoplastic Agents; Cell Culture Techniques; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Equilibrative Nucleoside Transporter 1; Floxuridine; Humans; Mycoplasma hyorhinis; Organophosphorus Compounds; Prodrugs; Pyrimidine Phosphorylases; Structure-Activity Relationship | 2011 |
Synthesis of 3'-azido-2',3'-dideoxy-5-fluorouridine phosphoramidates and evaluation of their anticancer activity.
Topics: Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Floxuridine; HeLa Cells; Humans; KB Cells; MCF-7 Cells; Molecular Structure; Structure-Activity Relationship; Tumor Cells, Cultured | 2013 |
Synthesis and biological activity of salinomycin conjugates with floxuridine.
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Design; Floxuridine; Humans; Methicillin-Resistant Staphylococcus aureus; Molecular Structure; Pyrans; Staphylococcus epidermidis; Structure-Activity Relationship | 2015 |
Synthesis and anticancer activity of some 5-fluoro-2'-deoxyuridine phosphoramidates.
Topics: Amides; Antineoplastic Agents; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deoxyuridine; Humans; Neoplasms; Phosphoric Acids | 2016 |
Synthesis, Antibacterial, and Anticancer Evaluation of Novel Spiramycin-Like Conjugates Containing C(5) Triazole Arm.
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Cell Line, Tumor; Cycloaddition Reaction; Drug Screening Assays, Antitumor; Gram-Positive Bacteria; Humans; Microbial Sensitivity Tests; Models, Molecular; Solubility; Spiramycin; Structure-Activity Relationship; Thermodynamics; Triazoles | 2016 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Adrenal suppression after short-term corticosteroid therapy.
Topics: Adrenal Cortex; Adrenal Insufficiency; Depression, Chemical; Floxuridine; Fluorouracil; Humans; In Vitro Techniques; Time Factors | 1979 |
New developments on the mechanisms of action of antineoplastic drugs.
Topics: Antineoplastic Agents; Bleomycin; Doxorubicin; Drug Interactions; Drug Synergism; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Methotrexate | 1979 |
Effect of deoxyuridine coadministration on toxicity and antitumor activity of fluorouracil and floxuridine.
Topics: Animals; Antineoplastic Agents; Biological Assay; Deoxyuridine; Drug Combinations; Drug Synergism; Female; Floxuridine; Fluorouracil; Lethal Dose 50; Mice; Sarcoma 180; Skin Neoplasms | 1975 |
The effects of 5-fluorouracil and 5-fluorodeoxyuridine used alone and in combination with normal nucleic acid precursors on development of mice in lines selected for low and high expression of Strong's luxoid gene.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Cell Survival; Drug Synergism; Female; Fetal Death; Floxuridine; Fluorouracil; Forelimb; Genes; Hindlimb; Mice; Mutation; Nucleic Acids; Pregnancy; Protein Precursors; Thymidine; Thymine; Tibia; Toes; Uracil | 1975 |
[Treatment of primary and secondary liver tumors using a combination of chemotherapy and surgery].
Topics: Antineoplastic Agents; Carmustine; Drug Therapy, Combination; Floxuridine; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Methods; Methotrexate; Remission, Spontaneous; Vincristine | 1975 |
The chemotherapy of urologic cancer.
Topics: Adenocarcinoma; Adult; Aged; Alkylating Agents; Antineoplastic Agents; Doxorubicin; Drug Therapy, Combination; Estradiol; Female; Floxuridine; Fluorouracil; Humans; Hydroxyurea; Kidney Neoplasms; Male; Methotrexate; Middle Aged; Mitomycins; Plicamycin; Prostatic Neoplasms; Testicular Neoplasms; Thiotepa; Urinary Bladder Neoplasms; Urogenital Neoplasms; Vincristine | 1975 |
Pyrimidine biosynthesis in Aspergillus nidulans. Isolation and characterisation of mutants resistant to fluoropyrimidines.
Topics: Aspergillus nidulans; Floxuridine; Fluorouracil; Mutation; Pyrimidines | 1975 |
Oncogenic transformation of C3H/10T1/2 clone 8 mouse embryo cells by halogenated pyrimidine nucleosides.
Topics: Animals; Antigens, Viral; Bromodeoxyuridine; Cell Division; Cell Line; Cell Transformation, Neoplastic; Clone Cells; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Idoxuridine; Mice; Oncogenic Viruses; Sarcoma, Experimental; Thymidine; Time Factors; Trifluridine | 1976 |
Schedule-dependent effect of phase-specific cytotoxic agents on production of hemolytic plaque-forming cells.
Topics: Animals; Antineoplastic Agents; Cytarabine; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Male; Methotrexate; Mice; Mice, Inbred AKR; Time Factors | 1976 |
[Hepatic metastases of cancers of the large intestine. Results of arterial chemotherapeutic treatment].
Topics: Female; Floxuridine; Fluorouracil; Humans; Injections, Intra-Arterial; Intestinal Neoplasms; Intestine, Large; Liver Neoplasms; Middle Aged; Neoplasm Metastasis; Perfusion | 1976 |
Comparative physiologic dispositions of 5-fluoro-2'-deoxyuridine and 5-fluorouracil in mice bearing solid L1210 lymphocytic leukemia.
Topics: Animals; Drug Administration Schedule; Floxuridine; Fluorouracil; Leukemia L1210; Mice | 1976 |
Chemotherapy of gastrointestinal cancer.
Topics: Doxorubicin; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Humans; Liver Neoplasms; Mitomycins; Nitrosourea Compounds; Pancreatic Neoplasms; Razoxane; Streptozocin | 1976 |
Toxoplasma gondii: characterization of a mutant resistant to 5-fluorodeoxyuridine.
Topics: Animals; Cell Line; Deoxyuridine; DNA; Drug Resistance; Floxuridine; Fluorouracil; Genes; Mutation; RNA; Thymidine; Toxoplasma; Uridine | 1977 |
Thymidine labeling index of human breast carcinoma. Enhancement of in vitro labeling by 5-fluorouracil and 5-fluoro-2'-deoxyuridine.
Topics: Breast Neoplasms; DNA, Neoplasm; Female; Floxuridine; Fluorouracil; Humans; In Vitro Techniques; Methyltransferases; Middle Aged; Thymidylate Synthase | 1977 |
Liposomal entrapment of floxuridine.
Topics: Chemistry, Pharmaceutical; Cholesterol; Diffusion; Eggs; Floxuridine; Fluorouracil; Liposomes; Phosphatidylcholines; Sphingomyelins; Sucrose; Time Factors | 1977 |
[Mechanism of the chromosome damaging effect of ftorafur].
Topics: Animals; Cell Line; Chromosome Aberrations; Chromosomes; Cricetinae; Floxuridine; Fluorouracil; Mitosis; Mutagens; Tegafur; Thymidine | 1977 |
Complications of long term transbrachial hepatic arterial infusion chemotherapy.
Topics: Adolescent; Adult; Aged; Brachial Artery; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Parenteral; Liver Neoplasms; Middle Aged; Thrombosis | 1977 |
Biochemical aspects of chemotherapy of mouse colon carcinoma: fluoropyrimidines and pyrazofurin.
Topics: Amidophosphoribosyltransferase; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Carcinoma; Colon; Colonic Neoplasms; DNA; DNA, Neoplasm; Floxuridine; Fluorouracil; Mice; Neoplasms, Experimental; Pyrimidine Nucleotides; Ribonucleosides; RNA; RNA, Neoplasm | 1977 |
Defective transport of thymidine by cultured cells resistant to 5-bromodeoxyuridine.
Topics: Biological Transport, Active; Bromodeoxyuridine; Drug Resistance; Floxuridine; Fluorouracil; HeLa Cells; Kinetics; Mutation; Ribonucleosides; Thymidine; Thymidine Kinase | 1977 |
Susceptibilities of normal and malignant human lung cells in culture to the cytocidal action of antitumor agents.
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line; Cell Survival; Doxorubicin; Drug Evaluation, Preclinical; Floxuridine; Fluorouracil; Humans; Kinetics; Lung; Lung Neoplasms; Neoplasms, Experimental | 1978 |
A clinical-pharmacological evaluation of hepatic arterial infusions of 5-fluoro-2'-deoxyuridine and 5-fluorouracil.
Topics: Adult; Aged; Drug Evaluation; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Infusions, Parenteral; Liver; Liver Neoplasms; Male; Middle Aged; Neoplasm Metastasis | 1978 |
Biochemical aspects of the interactions of the teratogens 5-fluorouracil and 5-fluorodeoxyuridine with normal nucleic acid precursors in mice selected for low and high expression of Strong's luxoid gene.
Topics: Animals; Carbon Radioisotopes; DNA; Embryo, Mammalian; Floxuridine; Fluorouracil; Mice; Mice, Mutant Strains; Nucleic Acid Precursors; RNA; Teratogens; Thymidine | 1978 |
Selectivity of action of 5-FU: biochemical basis.
Topics: Animals; Colonic Neoplasms; Drug Resistance; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Leukemia L1210; Mice; Mice, Inbred Strains; Rats; RNA, Neoplasm; Thymidine; Uridine | 1979 |
Potential clinical applications of a new method for quantitation of plasma levels of 5-fluorouracil and 5-fluorodeoxyuridine.
Topics: Chromatography, High Pressure Liquid; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Injections, Intraperitoneal; Methods | 1979 |
Mechanism of induction of gastrointestinal toxicity in the mouse by 5-fluorouracil, 5-fluorouridine, and 5-fluoro-2'-deoxyuridine.
Topics: Animals; Body Weight; Digestive System; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Lethal Dose 50; Male; Mice; Mice, Inbred CBA; RNA; Time Factors; Uridine | 1979 |
Studies on the mode of action of 5-fluorocytosine in Aspergillus species.
Topics: Aspergillus fumigatus; Aspergillus niger; Chromatography, Thin Layer; Cytosine; DNA; Drug Resistance, Microbial; Floxuridine; Flucytosine; Fluorouracil; Microbial Sensitivity Tests; Microbiological Techniques; RNA | 1979 |
Distinguishing between membrane transport and intracellular metabolism of fluorodeoxyuridine in Ehrlich ascites tumor cells by application of kinetic and high performance liquid chromatographic techniques.
Topics: Animals; Biological Transport, Active; Carcinoma, Ehrlich Tumor; Cell Membrane; Chromatography, High Pressure Liquid; Deoxyuridine; Floxuridine; Fluorouracil; Kinetics; Mice; Thymidine; Uridine | 1979 |
Colorectal carcinoma: overview of management techniques.
Topics: BCG Vaccine; Carcinoembryonic Antigen; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; Radiotherapy, High-Energy; Rectal Neoplasms | 1979 |
Prolonged and continuous percutaneous intra-arterial hepatic infusion chemotherapy in advanced metastatic liver adenocarcinoma from colorectal primary.
Topics: Adenocarcinoma; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Rectal Neoplasms; Thrombosis | 1979 |
Assay of intracellular free and macromolecular-bound metabolites of 5-fluorodeoxyuridine and 5-fluorouracil.
Topics: Animals; Chromatography, Gel; Culture Techniques; Cytosol; Deoxyuracil Nucleotides; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Kinetics; Leukemia L1210; Rats; RNA; Thymidine Kinase | 1979 |
Current status of regional arterial infusion chemotherapy.
Topics: Adenocarcinoma; Antineoplastic Agents; Carcinoma, Hepatocellular; Carotid Arteries; Catheterization; Chemotherapy, Cancer, Regional Perfusion; Floxuridine; Fluorouracil; Head and Neck Neoplasms; Hepatic Artery; Humans; Liver Neoplasms; Melanoma; Methotrexate; Mouth Neoplasms; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Neoplasms; Temporal Arteries; Time Factors | 1975 |
Clinical management of advanced gastrointestinal cancer.
Topics: Adenoma, Islet Cell; Carcinoma, Hepatocellular; Carmustine; Colonic Neoplasms; Cytarabine; Drug Therapy, Combination; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Humans; Liver Neoplasms; Lomustine; Malignant Carcinoid Syndrome; Mitomycins; Pancreatic Neoplasms; Rectal Neoplasms; Stomach Neoplasms; Streptozocin | 1975 |
The inhibition of ribosomal RNA synthesis and maturation in Novikoff hepatoma cells by 5-fluorouridine.
Topics: Animals; Carcinoma, Hepatocellular; Cells, Cultured; Floxuridine; Fluorouracil; In Vitro Techniques; Liver Neoplasms; Neoplasms, Experimental; RNA, Neoplasm; RNA, Ribosomal; Time Factors; Uridine | 1975 |
[Fluorinated pyrimidines administered by percutaneous arterial perfusion in primary or secondary cancers of the liver].
Topics: Carcinoma, Hepatocellular; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Neoplasm Metastasis | 1977 |
Treatment of primary liver cancer: response to regional chemotherapy.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Carcinoma, Hepatocellular; Chemotherapy, Cancer, Regional Perfusion; Doxorubicin; Female; Floxuridine; Fluorouracil; Hepatectomy; Humans; Liver Neoplasms; Male; Methotrexate; Middle Aged; Prognosis | 1979 |
Cytotoxic drugs and the human adrenal cortex: a cell culture study.
Topics: Adrenal Cortex; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Alkylating Agents; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Bucladesine; Cells, Cultured; Cyclic AMP; Floxuridine; Fluorouracil; Humans; Mitochondria; Vinca Alkaloids | 1979 |
In vitro drug combination of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil with anti-human immunodeficiency virus or anticancer nucleosides.
Topics: Antiviral Agents; Arabinofuranosyluracil; Bromouracil; Cytarabine; Drug Combinations; Floxuridine; Fluorouracil; Herpesvirus 3, Human; HIV-1; Humans; Zidovudine | 1992 |
In vitro enhancement of fluoropyrimidine-induced cytotoxicity by leucovorin in colorectal and gastric carcinoma cell lines but not in non-small-cell lung carcinoma cell lines.
Topics: Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Cell Survival; Colony-Forming Units Assay; Colorectal Neoplasms; Drug Synergism; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Leucovorin; Lung Neoplasms; Stomach Neoplasms; Tetrahydrofolates; Thymidylate Synthase; Tumor Cells, Cultured | 1992 |
Fatty acid conjugates of 2'-deoxy-5-fluorouridine as prodrugs for the selective delivery of 5-fluorouracil to tumor cells.
Topics: Cell Survival; Fatty Acids; Floxuridine; Fluorouracil; Humans; Lymphocytes; Phytohemagglutinins; Prodrugs; Tumor Cells, Cultured | 1992 |
Five-minute treatments with fluorouracil, floxuridine, and mitomycin have long-term effects on human Tenon's capsule fibroblasts.
Topics: Cell Division; Cells, Cultured; Connective Tissue; Connective Tissue Cells; Dose-Response Relationship, Drug; Eye; Fibroblasts; Floxuridine; Fluorouracil; Humans; Mitomycin; Osmolar Concentration; Time Factors | 1992 |
In vivo antitumor effects of fluoropyrimidines on colon adenocarcinoma 38 and enhancement by leucovorin.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Cell Division; Colonic Neoplasms; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Leucovorin; Male; Mice; Mice, Inbred Strains; Thymidylate Synthase; Uridine | 1992 |
The effect of liver macrophages on in vitro cytolytic activity of 5FU and FUdR on colon carcinoma cells: evidence of macrophage activation.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adenocarcinoma; Animals; Colonic Neoplasms; Cytotoxicity, Immunologic; Female; Floxuridine; Fluorouracil; Liver; Macrophage Activation; Rats; Rats, Inbred Strains; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1992 |
A comparative study of the antitumor activities of 5'-deoxy-5-fluorouridine and its prodrug trimethoxybenzoyl-5'-deoxy-5-fluorocytidine (Ro09-1390) on human digestive organ cancer xenograft lines transplanted into nude mice.
Topics: Animals; Antineoplastic Agents; Deoxycytidine; Digestive System Neoplasms; Floxuridine; Fluorouracil; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Prodrugs; Transplantation, Heterologous | 1992 |
Reversal of resistance to doxifluridine and fluorouracil in metastatic colorectal cancer: the role of high-dose folinic acid.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Resistance; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Metastasis | 1992 |
Enhancement of differentiation and cytotoxicity of leukemia cells by combinations of fluorinated pyrimidines and differentiation inducers: development of DNA double-strand breaks.
Topics: Cell Differentiation; Cell Line, Transformed; Dimethyl Sulfoxide; Drug Therapy, Combination; Floxuridine; Fluorouracil; Humans; Leukemia; Pyrimidines; Tretinoin; Tumor Cells, Cultured | 1992 |
Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules.
Topics: Cell Line; Cell Survival; Colonic Neoplasms; Drug Resistance; Floxuridine; Fluorouracil; Humans; Kinetics; Methotrexate; Pteroylpolyglutamic Acids; Pyrimidines; RNA, Neoplasm; Thymidylate Synthase; Time Factors | 1992 |
Effect of folinic acid on fluorouracil activity and expression of thymidylate synthase.
Topics: Animals; Colonic Neoplasms; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Leucovorin; Mice; Mice, Inbred BALB C; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured; Uridine Monophosphate | 1992 |
Mechanisms of resistance to fluoropyrimidines.
Topics: Cecal Neoplasms; Deoxyuracil Nucleotides; Drug Resistance; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Ileal Neoplasms; Leucovorin; Tetrahydrofolates; Thymidylate Synthase; Tumor Cells, Cultured | 1992 |
Determination of 5-fluorouracil and its main metabolites in plasma by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Hydrogen-Ion Concentration; Phosphates; Potassium; Potassium Compounds; Spectrophotometry, Ultraviolet; Uridine | 1992 |
In vitro release of hydrophobic drugs from polyanhydride disks.
Topics: Alkaloids; Cell Division; Cells, Cultured; Decanoic Acids; Delayed-Action Preparations; Dicarboxylic Acids; Drug Implants; Etoposide; Fibroblasts; Floxuridine; Fluorouracil; Glaucoma; Humans; Mercaptopurine; Paclitaxel; Polymers; Postoperative Complications; Vincristine | 1991 |
Evaluation of antiproliferative agents using a cell-culture model.
Topics: Animals; Bleomycin; Cell Count; Cell Division; Cells, Cultured; Colorimetry; Cricetinae; Cytarabine; Drug Evaluation, Preclinical; Floxuridine; Fluorouracil; Tetrazolium Salts; Thiazoles; Time Factors; Uridine | 1990 |
Variability of 5-bromo-2'-deoxyuridine incorporation into DNA of human glioma cell lines and modulation with fluoropyrimidines.
Topics: Bromodeoxyuridine; DNA, Neoplasm; Floxuridine; Fluorouracil; Glioma; Humans; Tumor Cells, Cultured | 1991 |
Activation and cytotoxicity of 5'-deoxy-5-fluorouridine in c-H-ras transformed NIH 3T3 cells.
Topics: Animals; Biotransformation; Cell Survival; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Genes, ras; Mice; Mice, Nude; Structure-Activity Relationship; Transfection; Tumor Cells, Cultured | 1991 |
Comparative DNA strand breakage induced by FUra and FdUrd in human ileocecal adenocarcinoma (HCT-8) cells: relevance to cell growth inhibition.
Topics: Adenocarcinoma; Cell Division; Colonic Neoplasms; DNA; DNA Damage; Dose-Response Relationship, Drug; Drug Synergism; Floxuridine; Fluorouracil; Humans; In Vitro Techniques; Leucovorin; Thymidine; Time Factors | 1991 |
[5-fluorouracil concentration in gastroenterological tumor tissues, in adjacent normal tissues, and in serum after preoperative oral administration of 5'-deoxy-5-fluorouridine (5'-DFUR)].
Topics: Administration, Oral; Colonic Neoplasms; Floxuridine; Fluorouracil; Gallbladder Neoplasms; Humans; Stomach Neoplasms | 1991 |
Pharmacokinetic aspects of arterial fluoropyrimidine delivery.
Topics: Animals; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial | 1991 |
[5-Fluorouracil level and pyrimidine nucleoside phosphorylase activity in cancer patients after oral administration of doxifluridine (5'-DFUR)].
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Aged, 80 and over; Breast Neoplasms; Colonic Neoplasms; Enzyme Activation; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Pentosyltransferases; Pyrimidine Phosphorylases; Stomach Neoplasms | 1991 |
Inhibition of fluoropyrimidine catabolism by benzyloxybenzyluracil. Possible relevance to regional chemotherapy.
Topics: Animals; Floxuridine; Fluorouracil; Liver; Male; Perfusion; Rats; Rats, Inbred Strains; Uracil | 1991 |
Gastrointestinal toxicity of 5-FU and 5-FUDR: radiographic findings.
Topics: Aged; Carcinoma; Duodenitis; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Ileitis; Infusion Pumps; Infusions, Intra-Arterial; Injections, Intravenous; Liver Neoplasms; Male; Middle Aged | 1991 |
The role of glutathione in evaluating the efficacy of antimetabolites in transplanted tumors.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Count; Female; Floxuridine; Fluorouracil; Glutathione; Liver; Mice; Microscopy, Fluorescence; Neoplasm Transplantation | 1991 |
Divergent patterns of incorporation of bromodeoxyuridine and iododeoxyuridine in human colorectal tumor cell lines.
Topics: Bromodeoxyuridine; Cell Division; Colorectal Neoplasms; DNA, Neoplasm; Floxuridine; Fluorouracil; Gas Chromatography-Mass Spectrometry; Humans; Idoxuridine; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 1991 |
The effects of gamma-interferon combined with 5-fluorouracil or 5-fluoro-2'-deoxyuridine on proliferation and antigen expression in a panel of human colorectal cancer cell lines.
Topics: Antibodies, Monoclonal; Carcinoembryonic Antigen; Cell Division; Cell Line; Colonic Neoplasms; Drug Interactions; Drug Screening Assays, Antitumor; Floxuridine; Fluorouracil; Histocompatibility Antigens Class I; Humans; Interferon-gamma; Kinetics; Recombinant Proteins; Rectal Neoplasms | 1991 |
Competitive binding radioassay for the determination of 5-fluorodeoxyuridine and 5-fluorodeoxyuridine-5'-monophosphate levels in plasma and tumor tissue.
Topics: Animals; Carcinoma, Ehrlich Tumor; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Kinetics; Lacticaseibacillus casei; Mice; Mice, Inbred Strains; Radioligand Assay; Thymidine Kinase; Thymidylate Synthase; Tritium | 1991 |
Highly sensitive method for the determination of 5-fluorouracil in biological samples in the presence of 2'-deoxy-5-fluorouridine by gas chromatography-mass spectrometry.
Topics: Acetamides; Animals; Floxuridine; Fluoroacetates; Fluorouracil; Gas Chromatography-Mass Spectrometry; Indicators and Reagents; Male; Organosilicon Compounds; Rats; Rats, Inbred Strains | 1991 |
[Comparative studies on the antitumor activity of fluorinated pyrimidine derivatives against human bladder, cervical and ovarian cancer xenografts in nude mice].
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Female; Floxuridine; Fluorouracil; Humans; Mice; Mice, Nude; Ovarian Neoplasms; Tegafur; Uracil; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms | 1991 |
Schedule-dependent enhancement of the cytotoxicity of fluoropyrimidines to human carcinoma cells in the presence of folinic acid.
Topics: Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Floxuridine; Fluorouracil; Humans; Leucovorin; Tumor Cells, Cultured | 1991 |
High-performance liquid chromatographic method for the simultaneous measurement of floxuridine and fluorouracil in human body fluids.
Topics: Ascitic Fluid; Body Fluids; Chromatography, High Pressure Liquid; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged | 1991 |
Colorectal metastases to the liver: present results and future strategies.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Combined Modality Therapy; Female; Floxuridine; Fluorouracil; Hepatectomy; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Survival Rate; Time Factors | 1991 |
[Phase II study of 5'-DFUR treatment of the bladder and prostatic cancer].
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anorexia; Antineoplastic Agents; Diarrhea; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Multicenter Studies as Topic; Nausea; Prostatic Neoplasms; Urinary Bladder Neoplasms | 1991 |
[Investigation of 5-fluorouracil (5-FU) levels and pyrimidine nucleoside phosphorylase activities in the tissues from patients with uterine cervical and ovarian cancers after oral administration of 5'-DFUR].
Topics: Administration, Oral; Antineoplastic Agents; Female; Floxuridine; Fluorouracil; Humans; Lymph Nodes; Ovarian Neoplasms; Ovary; Pentosyltransferases; Pyrimidine Phosphorylases; Uterine Cervical Neoplasms; Uterus | 1991 |
Comparative antitumor activity of 5-fluorouracil and its prodrugs in combination with hyperthermia in vitro.
Topics: Antineoplastic Agents; Cell Survival; Floxuridine; Fluorouracil; Hot Temperature; Humans; Infant, Newborn; Prodrugs; Tegafur; Tumor Cells, Cultured | 1991 |
[Regional chemotherapy of diffuse liver metastases of colorectal cancer].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Combined Modality Therapy; Female; Floxuridine; Fluorouracil; Follow-Up Studies; Humans; Infusion Pumps; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Mitomycin; Survival Rate | 1991 |
Pharmacokinetic study of doxifluridine given by 5-day stepped-dose infusion.
Topics: Adult; Aged; Antineoplastic Agents; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms | 1990 |
In vivo 19F NMR spectroscopy of the antimetabolite 5-fluorouracil and its analogues. An assessment of drug metabolism.
Topics: Animals; Antineoplastic Agents; beta-Alanine; Carcinoid Tumor; Female; Floxuridine; Fluorouracil; Infusions, Intravenous; Liver; Magnetic Resonance Spectroscopy; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Tegafur | 1990 |
Differential effects of 2,2'-anhydro-5-ethyluridine, a uridine phosphorylase inhibitor, on the antitumor activity of 5-fluorouridine and 5-fluoro-2'-deoxyuridine.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Drug Interactions; Floxuridine; Fluorouracil; Humans; Kinetics; Male; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Neoplasm Transplantation; Pentosyltransferases; Thymidine Phosphorylase; Tumor Cells, Cultured; Uridine; Uridine Phosphorylase | 1990 |
Hepatic artery infusion pumps: cannulation techniques and other surgical considerations.
Topics: Animals; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Liver Neoplasms; Postoperative Complications | 1990 |
[Animal experiment studies of the toxicity of fluorodeoxyuridine (FUDR) and 5-fluorouracil (FU) within the scope of regional liver infusion chemotherapy].
Topics: Animals; Bile; Chemical and Drug Induced Liver Injury; Female; Floxuridine; Fluorouracil; Inactivation, Metabolic; Infusions, Intra-Arterial; Liver; Rats; Rats, Inbred Strains | 1990 |
Comparative antitumor activity and intestinal toxicity of 5'-deoxy-5-fluorouridine and its prodrug trimethoxybenzoyl-5'-deoxy-5-fluorocytidine.
Topics: Animals; Antineoplastic Agents; Deoxycytidine; Floxuridine; Fluorouracil; Intestines; Male; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Prodrugs | 1990 |
[A study on preoperative administration of doxifluridine in carcinoma of the colon and rectum].
Topics: Adenocarcinoma; Administration, Oral; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Lymph Nodes; Preoperative Care | 1990 |
[Chemotherapy with fluoropyrimidines for MOPC-104E plasmacytoma transplanted in mice with CCl4 induced chronic liver dysfunction].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Floxuridine; Fluorouracil; Male; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Plasmacytoma; Tegafur; Uracil | 1990 |
Optimal treatment regimens for 5'-deoxy-5-fluorouridine, with or without (E)-5-(2-bromovinyl)-2'-deoxyuridine, against various tumors in mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antiviral Agents; Bromodeoxyuridine; Colonic Neoplasms; Drug Therapy, Combination; Floxuridine; Fluorouracil; Liver Neoplasms; Lung Neoplasms; Mice; Mice, Inbred BALB C; Pentosyltransferases; Prodrugs; Pyrimidine Phosphorylases | 1990 |
Resistance to 5-fluorouracil and 5-fluoro-2'-deoxyuridine mechanisms and clinical implications.
Topics: Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Resistance; Floxuridine; Fluorouracil; Humans; Time Factors; Tumor Cells, Cultured | 1990 |
[The study of 5-FU levels and pyrimidine nucleoside phosphorylase (PyNPase) activity in human breast cancer tissue after administration of 5'-deoxy-5-fluorouridine (5'-DFUR)].
Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Middle Aged; Pentosyltransferases; Pyrimidine Phosphorylases | 1990 |
Nonlinear elimination kinetics of 5-fluoro-2'-deoxyuridine in isolated perfused rat liver and isolated hepatocytes.
Topics: Animals; beta-Alanine; Chromatography, Thin Layer; Floxuridine; Fluorouracil; Half-Life; Liver; Male; Rats; Rats, Inbred Strains | 1990 |
[Preoperative chemotherapy and anti-cancer effect of gastric carcinoma].
Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Drug Evaluation; Floxuridine; Fluorouracil; Gastrectomy; Humans; Middle Aged; Neoplasm Staging; Preoperative Care; Stomach Neoplasms | 1990 |
Regional chemotherapy in liver metastases of colorectal carcinoma: monitoring with arterial computed tomography.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Doxorubicin; Female; Floxuridine; Fluorouracil; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Mitomycin; Mitomycins; Monitoring, Physiologic; Survival Rate; Tomography, X-Ray Computed | 1990 |
Modulation of fluoropyrimidines by pretreatment with antifolates or folinic acid (leucovorin).
Topics: Antineoplastic Combined Chemotherapy Protocols; Drug Synergism; Floxuridine; Fluorouracil; Humans; Leucovorin; Methotrexate; Neoplasms | 1990 |
Kinetic analysis of 5-fluorouracil action against various cancer cells.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Colonic Neoplasms; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Humans; Kidney Neoplasms; Leukemia P388; Mice; RNA, Ribosomal; S Phase; Time Factors; Uridine | 1990 |
[A study on pre-operative administration of 5'-DFUR in carcinomas of the gastric, breast, thyroid and colon].
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Cycle; Colonic Neoplasms; Combined Modality Therapy; Female; Floxuridine; Fluorouracil; Humans; Lymph Nodes; Pentosyltransferases; Preoperative Care; Pyrimidine Phosphorylases; Stomach Neoplasms; Thyroid Neoplasms; Tissue Distribution | 1990 |
Fluorodeoxyuridine-induced radiosensitization and inhibition of DNA double strand break repair in human colon cancer cells.
Topics: Cell Survival; Colonic Neoplasms; DNA Damage; DNA Repair; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Humans; Interphase; Radiation Tolerance; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 1990 |
Circadian rhythm of hepatic uridine phosphorylase activity and plasma concentration of uridine in mice.
Topics: Animals; Circadian Rhythm; Female; Floxuridine; Fluorouracil; Liver; Male; Mice; Uridine; Uridine Phosphorylase | 1990 |
High-performance liquid chromatography with chemiluminescence detection of serum levels of pre-column derivatized fluoropyrimidine compounds.
Topics: Chromatography, High Pressure Liquid; Coumarins; Floxuridine; Fluorine; Fluorouracil; Humans; Molecular Structure; Pyrimidines; Tegafur; Umbelliferones; Uridine | 1990 |
Enhancement of fluorinated pyrimidine-induced cytotoxicity by leucovorin in human lung cancer cell lines.
Topics: Adenocarcinoma; Adenocarcinoma, Bronchiolo-Alveolar; Carcinoma, Squamous Cell; Cell Line; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug Synergism; Floxuridine; Fluorouracil; Humans; Leucovorin; Lung Neoplasms; Tumor Cells, Cultured | 1990 |
Sensitivity of human, murine, and rat cells to 5-fluorouracil and 5'-deoxy-5-fluorouridine in relation to drug-metabolizing enzymes.
Topics: Animals; Cells, Cultured; DNA; Floxuridine; Fluorouracil; Humans; Mice; Orotate Phosphoribosyltransferase; Rats; RNA; Thymidylate Synthase; Uridine Kinase; Uridine Phosphorylase | 1986 |
[5'-Deoxy-5-fluorouridine and 5-fluorouracil concentrations and thymidine phosphorylase activity in brain tumors following intravenous administration of 5'-deoxy-5-fluorouridine].
Topics: Adult; Aged; Astrocytoma; Brain Neoplasms; Cerebral Ventricle Neoplasms; Child; Choroid Plexus; Ependymoma; Female; Floxuridine; Fluorouracil; Glioma; Humans; Infant; Male; Middle Aged; Papilloma; Pentosyltransferases; Thymidine Phosphorylase | 1985 |
Modulation of cytotoxicity and metabolism of 5-fluorouracil in two intestine cell lines.
Topics: Cell Cycle; Cell Line; DNA; Drug Synergism; Floxuridine; Fluorouracil; Humans; Hypoxanthine; Hypoxanthines; In Vitro Techniques; Inosine; Organophosphorus Compounds; Pentosyltransferases; Pyrimidine Phosphorylases; Ribosemonophosphates; RNA; Thymidine; Thymidylate Synthase | 1986 |
Correlation between ribosomal RNA production and RNA-directed fluoropyrimidine cytotoxicity.
Topics: Animals; Cell Nucleus; Cell Survival; Cytoplasm; DNA; Floxuridine; Fluorouracil; Mice; RNA; RNA, Messenger; RNA, Ribosomal; Sarcoma 180; Uridine | 1987 |
Interferon effects upon the adenocarcinoma 38 and HL-60 cell lines: antiproliferative responses and synergistic interactions with halogenated pyrimidine antimetabolites.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Cell Division; Drug Synergism; Floxuridine; Fluorouracil; Humans; Interferons; Leukemia, Myeloid, Acute; Recombinant Proteins; Tumor Cells, Cultured | 1988 |
A phase I clinical trial of combined fluoropyrimidines with leucovorin in a 14-day infusion. Demonstration of biochemical modulation.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Diarrhea; Drug Administration Schedule; Drug Evaluation; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Neoplasms; Remission Induction; Stomatitis | 1989 |
Combined 5-fluorouracil and floxuridine administered as a 14-day infusion. A phase I study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoembryonic Antigen; Catheterization, Central Venous; Drug Administration Schedule; Drug Combinations; Drug Evaluation; Enteritis; Floxuridine; Fluorouracil; Humans; Neoplasms | 1989 |
5-Fluoropyrimidine-induced DNA damage in human colon adenocarcinoma and its augmentation by the nucleoside transport inhibitor dipyridamole.
Topics: Adenocarcinoma; Colonic Neoplasms; Dipyridamole; DNA; DNA Damage; Floxuridine; Fluorouracil; Humans; Methotrexate; Nucleosides; Tumor Cells, Cultured | 1989 |
[The serum and tissue concentration of FT-207, 5'-DFUR and 5-FU in patients with breast cancer by preoperative administration of UFT and 5'-DFUR].
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast; Breast Neoplasms; Floxuridine; Fluorouracil; Humans; Lymph Nodes; Preoperative Care; Tegafur; Tissue Distribution; Uracil | 1989 |
Enhanced therapeutic efficacy of 5'deoxy-5-fluorouridine in 5-fluorouracil resistant head and neck tumours in relation to 5-fluorouracil metabolising enzymes.
Topics: Animals; Antineoplastic Agents; Carcinoma; Colonic Neoplasms; Drug Resistance; Female; Floxuridine; Fluorouracil; Head and Neck Neoplasms; Isomerism; Mice; Mice, Nude; Neoplasm Transplantation; Pentosyltransferases; Pyrimidine Phosphorylases | 1989 |
Effects of pyrimidine nucleoside phosphorylase inhibitors on hepatic fluoropyrimidine elimination in the rat.
Topics: Animals; Floxuridine; Fluorouracil; Kinetics; Liver; Male; Pentosyltransferases; Perfusion; Pyridines; Pyrimidine Phosphorylases; Rats; Rats, Inbred Strains | 1989 |
Enhanced antitumor effect of 5'-deoxy-5-fluorouridine by oral administration with L-cysteine.
Topics: Adenocarcinoma; Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Chromatography, High Pressure Liquid; Colonic Neoplasms; Cysteine; Drug Synergism; Floxuridine; Fluorouracil; Humans; Injections, Intravenous; Lung Neoplasms; Male; Mice | 1989 |
[Two cases of gastrointestinal cancers with major responses to sequential methotrexate 5-FU plus 5'-DFUR].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carcinoembryonic Antigen; Colonic Neoplasms; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Lymphatic Metastasis; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Remission Induction; Stomach Neoplasms | 1989 |
Enhancing effect of bromovinyldeoxyuridine on antitumor activity of 5'-deoxy-5-fluorouridine against adenocarcinoma 755 in mice. Correlation with pharmacokinetics of plasma 5-fluorouracil levels.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Bromodeoxyuridine; Chromatography, High Pressure Liquid; Drug Synergism; Floxuridine; Fluorouracil; Half-Life; Male; Mice; Neoplasm Transplantation; Spectrophotometry, Ultraviolet | 1989 |
MTX-5-FU combination therapy compared to FUDR monotherapy in nude mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Methotrexate; Mice; Mice, Nude; Neoplasm Transplantation; Transplantation, Heterologous | 1989 |
Sequence-dependent enhancement of HCT-8 cell kill by trimetrexate and fluoropyrimidines: implications for the mechanism of this interaction.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Colony-Forming Units Assay; Drug Interactions; Drug Synergism; Floxuridine; Fluorouracil; Folic Acid Antagonists; Humans; Methotrexate; Quinazolines; Trimetrexate; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1989 |
Intra-arterial hepatic chemotherapy for metastatic liver from colo-rectal carcinoma origin.
Topics: Adenocarcinoma; Adult; Aged; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusion Pumps; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Thrombosis | 1989 |
Combination of cisplatin plus fluoropyrimidine chemotherapy effective against liver metastases from carcinoma of the anal canal.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Anus Neoplasms; Carcinoma, Squamous Cell; Cisplatin; Female; Floxuridine; Fluorouracil; Humans; Liver Neoplasms; Middle Aged; Tomography, X-Ray Computed | 1989 |
Comparative antitumor activity of 5-fluorouracil and 5'-deoxy-5-fluorouridine in combination with radiation therapy in mice bearing colon 26 adenocarcinoma.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Bone Marrow; Colonic Neoplasms; Combined Modality Therapy; Female; Floxuridine; Fluorouracil; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Spleen; Thymus Gland; Weight Gain | 1989 |
Activity of thymidylate synthetase and its inhibition by 5-fluorouracil in highly enzyme-overproducing cells resistant to 10-propargyl-5,8-dideazafolate.
Topics: Animals; Blotting, Southern; Drug Resistance; Floxuridine; Fluorouracil; Folic Acid; Gene Amplification; Mice; Quinazolines; Thymidylate Synthase; Tumor Cells, Cultured | 1989 |
[Evaluation of long survival cases treated with intra-arterial cancer chemotherapy using implantable reservoirs].
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Doxorubicin; Evaluation Studies as Topic; Female; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Humans; Infusion Pumps; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Quality of Life | 1989 |
[In vitro studies of 5-FU sensitivity on uterine cervical cancer cell lines--comparison between squamous cell carcinoma and adenocarcinoma].
Topics: Adenocarcinoma; Carcinoma, Squamous Cell; Cell Survival; DNA, Neoplasm; Drug Screening Assays, Antitumor; Female; Floxuridine; Fluorouracil; Humans; Thymidylate Synthase; Tumor Cells, Cultured; Uterine Cervical Neoplasms | 1989 |
Regional chemotherapy for hepatic metastases from colorectal carcinoma.
Topics: Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Liver Neoplasms | 1989 |
Transport and intracellular metabolism of fluorinated pyrimidines in cultured cell lines.
Topics: Animals; Biological Transport; Erythrocytes; Floxuridine; Fluorouracil; HeLa Cells; Humans; Leukemia L1210; Mice; Tumor Cells, Cultured; Uridine | 1989 |
Fluoropyrimidine metabolism in human head and neck cancer xenografts and murine colon tumors.
Topics: Animals; Colonic Neoplasms; Drug Screening Assays, Antitumor; Floxuridine; Fluorouracil; Head and Neck Neoplasms; Humans; Mice; Neoplasm Transplantation; Orotate Phosphoribosyltransferase; Pentosyltransferases; Pyrimidine Phosphorylases; Tumor Cells, Cultured | 1989 |
Isolation of a thymidine kinase negative mutant of Nocardia lactamdurans.
Topics: DNA, Bacterial; Floxuridine; Fluorouracil; Mutation; Nocardia; Phenotype; Thymidine; Thymidine Kinase; Thymine | 1989 |
[Potentialities of fluorine-19 and phosphorus-31 NMR for studying the metabolism and pharmacokinetics of fluorinated or phosphoric antineoplastic agents].
Topics: Floxuridine; Fluorine; Fluorouracil; Humans; Ifosfamide; Magnetic Resonance Spectroscopy; Phosphorus | 1989 |
Enhancement of fluoropyrimidine inhibition of cell growth by leucovorin and deoxynucleosides in a human squamous cell carcinoma cell line.
Topics: Carcinoma, Squamous Cell; Culture Media; Deoxyribonucleosides; Drug Synergism; Floxuridine; Fluorouracil; Humans; Leucovorin; Tumor Cells, Cultured | 1989 |
Treatment of liver metastases from colorectal cancer with continuous high dose intra-arterial floxuridine (FUDR) and systemic fluorouracil: a phase II study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Evaluation; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged | 1989 |
Overexpression of DNA replication and repair enzymes in cisplatin-resistant human colon carcinoma HCT8 cells and circumvention by azidothymidine.
Topics: Cell Line; Cisplatin; Colonic Neoplasms; DNA Polymerase I; DNA Polymerase II; DNA Repair; DNA Replication; Drug Resistance; Etoposide; Floxuridine; Fluorouracil; Humans; Methotrexate; Tetrahydrofolate Dehydrogenase; Thymidine Kinase; Thymidylate Synthase; Tumor Cells, Cultured; Zidovudine | 1989 |
Extraction of intracellular nucleosides and nucleotides with acetonitrile.
Topics: Acetonitriles; Animals; Bone Marrow; Chemical Precipitation; Chromatography, High Pressure Liquid; Female; Floxuridine; Fluorouracil; Hydroxides; Indicators and Reagents; Intestinal Mucosa; Intestines; Nucleosides; Nucleotides; Perchlorates; Potassium; Potassium Compounds; Rats; Tritium | 1989 |
Antagonistic effect of polyinosinic-polycytidylic acid on the cell lethality produced by 5-fluorouracil in human colon carcinoma cells in vitro.
Topics: Cell Survival; Cells, Cultured; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; Interferons; Poly C; Poly I; Poly I-C; RNA | 1985 |
[Anticancer treatment with a combination of antimetabolites of polyamine and pyrimidine].
Topics: Animals; DNA Replication; Drug Therapy, Combination; Eflornithine; Floxuridine; Fluorouracil; Mice; Mice, Nude; Mitoguazone; Ornithine; Polyamines; Spermine; Stomach Neoplasms | 1985 |
Hepatic arterial and systemic chemotherapy for the treatment of primary and secondary malignancies of the liver.
Topics: Administration, Oral; Adult; Antineoplastic Combined Chemotherapy Protocols; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Infusions, Parenteral; Liver Neoplasms; Lomustine; Male; Mitomycin; Mitomycins; Time Factors | 1985 |
Use of 5-trifluoromethyldeoxycytidine and tetrahydrouridine to circumvent catabolism and exploit high levels of cytidine deaminase in tumors to achieve DNA- and target-directed therapies.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cells, Cultured; Cytidine Deaminase; Deoxycytidine; DNA; Female; Floxuridine; Fluorouracil; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasms, Experimental; Nucleoside Deaminases; Tetrahydrouridine; Thymidylate Synthase; Trifluridine; Uridine | 1985 |
Pharmacology of 5'-deoxy-5-fluorouridine in patients with resistant ovarian cancer.
Topics: Adult; Aged; Antineoplastic Agents; Female; Floxuridine; Fluorouracil; Humans; Kinetics; Middle Aged; Ovarian Neoplasms | 1985 |
Analysis of 5'-deoxy-5-fluorouridine and 5-fluorouracil in human plasma and urine by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Floxuridine; Fluorouracil; Humans; Hydrogen-Ion Concentration; Kinetics; Spectrophotometry, Ultraviolet | 1985 |
Modulation of 5-iodo-2'-deoxyuridine metabolism and cytotoxicity in human bladder cancer cells by fluoropyrimidines.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Line; Cell Survival; DNA; Floxuridine; Fluorouracil; Humans; Idoxuridine; Urinary Bladder Neoplasms | 1985 |
The therapeutic effects of orally administered 5'-deoxy-5-fluorouridine, 1-(2-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil on experimental murine tumors.
Topics: Animals; Antineoplastic Agents; Floxuridine; Fluorouracil; Leukemia L1210; Mice; Neoplasms, Experimental; Tegafur | 1985 |
Hepatic artery infusion chemotherapy for colorectal metastases: a personal experience.
Topics: Adult; Aged; Carcinoma; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Mitomycins; Postoperative Complications; Rectal Neoplasms | 1985 |
The implantable "Infusaid" infusion pump. The Sydney experience using 5-fluorouracil.
Topics: Australia; Colonic Neoplasms; Floxuridine; Fluorouracil; Gastrointestinal Hemorrhage; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged | 1986 |
Antimutagenic effects of 5-fluorouracil and 5-fluorodeoxyuridine on UV-induced mutagenesis in Escherichia coli.
Topics: Alkaline Phosphatase; DNA Repair; Escherichia coli; Floxuridine; Fluorouracil; Genes; Genes, Bacterial; Mutagenicity Tests; Mutation; Structure-Activity Relationship; Ultraviolet Rays | 1986 |
Chemical cholecystitis after intrahepatic chemotherapy. The case for prophylactic cholecystectomy during pump placement.
Topics: Adult; Cholecystectomy; Cholecystitis; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Middle Aged; Nitrosourea Compounds; Semustine | 1986 |
The mechanism of dNTP-unbalanced cell death induced by 5-fluorouracil and its derivatives.
Topics: Animals; Cell Line; Cell Survival; Deoxyribonucleotides; Floxuridine; Fluorouracil; Kinetics; Mammary Neoplasms, Experimental; Mice | 1985 |
Evidence for the importance of 5'-deoxy-5-fluorouridine catabolism in humans from 19F nuclear magnetic resonance spectrometry.
Topics: Aged; Antineoplastic Agents; beta-Alanine; Female; Floxuridine; Fluorouracil; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Urea | 1986 |
Incorporation of intermediary products of 5-FU anabolism into colorectal cancer.
Topics: Aged; Colon; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Intestinal Mucosa; Male; Rectal Neoplasms; Uridine | 1986 |
Experiments on the efficacy and toxicity of locoregional chemotherapy of liver tumors with 5-fluoro-2'-deoxyuridine (FUDR) and 5-fluorouracil (5-FU) in an animal model.
Topics: Animals; DNA, Neoplasm; Floxuridine; Fluorouracil; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Rats | 1986 |
Enhancement of fluoropyrimidine cytotoxicity by 5-methyltetrahydrofolate in a human leukemia cell line, CCRF-CEM.
Topics: Cell Division; Cell Line; Drug Synergism; Floxuridine; Fluorouracil; Humans; Leukemia; Tetrahydrofolates; Time Factors | 1985 |
Increased thymidylate synthase in L1210 cells possessing acquired resistance to N10-propargyl-5,8-dideazafolic acid (CB3717): development, characterization, and cross-resistance studies.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Deoxyuridine; Drug Resistance; Floxuridine; Fluorouracil; Folic Acid; Folic Acid Antagonists; Hypoxanthine; Hypoxanthines; Kinetics; Leukemia L1210; Mice; Quinazolines; Thymidylate Synthase; Tritium | 1986 |
Fluoropyrimidine treatment of ocular cicatricial disease.
Topics: Animals; Cell Division; Cicatrix; Eye Diseases; Fibroblasts; Floxuridine; Fluorouracil; Osmolar Concentration; Rabbits; Skin; Uridine | 1986 |
Precursor-dependent differences in the incorporation of fluorouracil in RNA.
Topics: Animals; Cell Survival; Cells, Cultured; Floxuridine; Fluorouracil; Mice; RNA, Neoplasm; Sarcoma, Experimental; Thymidine; Uridine | 1986 |
Implantable vascular access devices in the treatment of colorectal liver metastases.
Topics: Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Prostheses and Implants; Rectal Neoplasms | 1986 |
On the differential affinities of two anticancer analogues to their target.
Topics: Adenocarcinoma; Chromatography, High Pressure Liquid; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Kinetics; Liver Circulation; Liver Neoplasms; Male; Middle Aged | 1985 |
Combined therapy of polyamine antimetabolites and antitumor drugs for human gastric cancer xenotransplanted into nude mice.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Carcinoma; Eflornithine; Floxuridine; Fluorouracil; Mice; Mice, Inbred BALB C; Mice, Nude; Mitoguazone; Neoplasm Transplantation; Nimustine; Nitrosourea Compounds; Ornithine; Stomach Neoplasms | 1986 |
An implantable pump for regional chemotherapy of liver metastases.
Topics: Adult; Aged; Catheters, Indwelling; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged | 1986 |
DNA lesions in human neoplastic cells and cytotoxicity of 5-fluoropyrimidines.
Topics: Aphidicolin; Cell Survival; Centrifugation, Density Gradient; Diterpenes; DNA, Neoplasm; Floxuridine; Fluorouracil; Humans; Methotrexate; Neoplasms; Time Factors | 1986 |
Enhancement of the effects of 5-fluorouracil.
Topics: Antineoplastic Combined Chemotherapy Protocols; Drug Evaluation; Drug Synergism; Floxuridine; Fluorouracil; Humans; Methotrexate; Neoplasms; Pyrimidines | 1986 |
Experiments on the toxicity of locoregional liver chemotherapy with 5-fluoro-2'-deoxyuridine and 5-fluorouracil in an animal model.
Topics: Animals; Female; Floxuridine; Fluorouracil; Hepatic Artery; Infusions, Intra-Arterial; Infusions, Parenteral; Liver; Liver Neoplasms, Experimental; Portal Vein; Rats; Rats, Inbred Strains | 1986 |
Modulation of the effects of fluoropyrimidines on toxicity and tumor inhibition in rodents by uridine and thymidine.
Topics: Animals; Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Leukemia L1210; Lung Neoplasms; Male; Mice; Rats; Rats, Inbred Strains; Sarcoma 180; Thymidine; Uridine | 1986 |
Folinic acid augmentation of the effects of fluoropyrimidines on murine and human leukemic cells.
Topics: Animals; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Floxuridine; Fluorouracil; Folic Acid; Humans; Leucovorin; Leukemia; Leukemia L1210; Mice | 1986 |
Noninvasive fluorine-19 NMR study of fluoropyrimidine metabolism in cell cultures of human pancreatic and colon adenocarcinoma.
Topics: Adenocarcinoma; Cells, Cultured; Colonic Neoplasms; Floxuridine; Fluorine; Fluorouracil; Humans; Macromolecular Substances; Magnetic Resonance Spectroscopy; Pancreatic Neoplasms; Spectrum Analysis | 1986 |
Toxicity and antitumor effect of 5-fluorouracil and its rescue by uridine.
Topics: Animals; Body Temperature Regulation; Carcinoma; Colonic Neoplasms; Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Hematopoiesis; Leukocyte Count; Mice; Uridine | 1986 |
Alteration of fluorouracil metabolism in human colon cancer cells by dipyridamole with a selective increase in fluorodeoxyuridine monophosphate levels.
Topics: Cells, Cultured; Colonic Neoplasms; Deoxyuracil Nucleotides; Deoxyuridine; Dipyridamole; DNA; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Ribonucleotides; Time Factors; Uridine Triphosphate | 1986 |
Passage of 5'-dFUrd and its metabolites 5-FU and 5-FUH2 to CSF in a clinical phase 1 study.
Topics: Adult; Aged; Drug Evaluation; Female; Floxuridine; Fluorouracil; Humans; Kinetics; Male; Middle Aged | 1986 |
[The determination of thymidylate synthetase inhibition for testing fluoropyrimidines--pharmacokinetics and metabolism of carmofur (HCFU) in patients with gynecologic malignancies--Tokai HCFU Study Group for Gynecologic Malignancies].
Topics: Antineoplastic Agents; Female; Floxuridine; Fluorouracil; Genital Neoplasms, Female; Half-Life; Humans; Kinetics; Thymidylate Synthase | 1986 |
Comparison of 5-FU versus FUDR activity in human colorectal cancer using an in vitro clonogenic assay (HTCA).
Topics: Colonic Neoplasms; Colony-Forming Units Assay; Culture Techniques; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Humans; Rectal Neoplasms; Tumor Stem Cell Assay | 1986 |
Role of administration route in the therapeutic efficacy of doxifluridine.
Topics: Administration, Oral; Animals; Biological Availability; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Infusions, Intravenous; Injections, Intravenous; Kinetics; Neoplasm Transplantation; Rats; Rats, Inbred F344 | 1987 |
Dose-dependent elimination of 5-fluoro-2'-deoxyuridine in the monkey.
Topics: Animals; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Humans; Kinetics; Macaca fascicularis; Macaca mulatta; Rats | 1987 |
Treatment of liver metastases with a combination of chemotherapy and hyperfractionated external radiation therapy.
Topics: Combined Modality Therapy; Floxuridine; Fluorouracil; Humans; Liver; Liver Neoplasms | 1987 |
Selection of therapeutic agents for intraocular proliferative disease. II. Differing antiproliferative activity of the fluoropyrimidines.
Topics: Animals; Antineoplastic Agents; Cattle; Cell Division; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Eye Neoplasms; Floxuridine; Flucytosine; Fluorouracil; Humans; Uridine | 1987 |
Cytotoxicity of floxuridine and 5-fluorouracil in human T-lymphoblast leukemia cells: enhancement by leucovorin.
Topics: Cell Division; Cell Line; Cell Survival; Drug Synergism; Floxuridine; Fluorouracil; Humans; Leucovorin; Leukemia, Lymphoid; T-Lymphocytes; Thymidine | 1987 |
Enzymatic cleavage of various fluorinated pyrimidine nucleosides to 5-fluorouracil and their antiproliferative activities in human and murine tumor cells.
Topics: Animals; Cell Division; Floxuridine; Fluorouracil; Humans; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Substrate Specificity; Thymidine Phosphorylase; Uridine Phosphorylase | 1986 |
Tumor-selective metabolism of 5-fluoro-2'-deoxycytidine coadministered with tetrahydrouridine compared to 5-fluorouracil in mice bearing Lewis lung carcinoma.
Topics: Animals; Antimetabolites; Deoxycytidine; Female; Floxuridine; Fluorouracil; Lung Neoplasms; Mice; Tetrahydrouridine; Uridine | 1987 |
High-performance liquid chromatographic analysis of fluoropyrimidine nucleosides and fluorouracil in plasma.
Topics: Animals; Chromatography, Gas; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Floxuridine; Fluorouracil; Humans; Kinetics; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet | 1987 |
[Combination chemotherapy with 3 or 4 drugs on human breast and gastrointestinal cancer xenografts in nude mice (II)].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Colonic Neoplasms; Cyclophosphamide; Doxorubicin; Female; Floxuridine; Fluorouracil; Humans; Methotrexate; Mice; Mice, Nude; Mitomycin; Mitomycins; Neoplasm Transplantation; Stomach Neoplasms; Tegafur; Vindesine | 1987 |
[5'-DFUR (doxifluridine)].
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Drug Evaluation; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Humans; Liver Neoplasms, Experimental; Mice; Sarcoma, Experimental | 1987 |
[BOF-A1 and BOF-A2, new 5-FU degradation-inhibitory agents].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Floxuridine; Fluorouracil; Liver; Mice; Pyridines; Pyrimidines; Rats; Sarcoma 180; Sarcoma, Experimental; Sarcoma, Yoshida; Tegafur; Uracil | 1987 |
The relationship between plasma pharmacokinetics and tissue metabolites of 5-fluorouracil (5-FU) in patients with colorectal cancer.
Topics: Aged; Aged, 80 and over; Colon; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Kinetics; Male; Middle Aged; Rectal Neoplasms; Uridine | 1987 |
Regional and systemic chemotherapy for colorectal metastases to the liver.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Prognosis; Rectal Neoplasms | 1987 |
Reduced hippocampal field potentials during administration of fluoropyrimidines in vitro.
Topics: Action Potentials; Animals; Evoked Potentials; Floxuridine; Fluorouracil; Hippocampus; In Vitro Techniques; Nerve Fibers; Rats; Rats, Inbred Strains; Synapses | 1987 |
Effects of 5-methyltetrahydrofolate on the activity of fluoropyrimidines against human leukemia (CCRF-CEM) cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cell Line; Dose-Response Relationship, Drug; Drug Synergism; Floxuridine; Fluorouracil; Humans; Leukemia, Lymphoid; Methionine; Tetrahydrofolates; Thymidine | 1987 |
[Conversion of 5'-deoxy-5-fluorouridine to 5-FU by pyrimidine nucleoside phosphorylases in normal and tumor tissues from rodents bearing tumors and cancer patients].
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Floxuridine; Fluorouracil; Humans; Leukemia L1210; Leukemia P388; Mice; Neoplasms; Neoplasms, Experimental; Pentosyltransferases; Pyrimidine Phosphorylases; Rats; Sarcoma 180 | 1987 |
Myocardial ischemia with fluorouracil and floxuridine therapy.
Topics: Adenocarcinoma; Aged; Colonic Neoplasms; Coronary Disease; Electrocardiography; Floxuridine; Fluorouracil; Humans; Male | 1987 |
[Locoregional chemotherapy of hepatic metastases of colorectal cancer].
Topics: Adenocarcinoma; Adult; Aged; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; Infusion Pumps; Infusions, Intra-Arterial; Liver Neoplasms; Middle Aged; Rectal Neoplasms | 1987 |
Biochemical rationale for the synergism of 5-fluorouracil and folinic acid.
Topics: Animals; Cell Division; Cell Survival; Deoxyuracil Nucleotides; Drug Synergism; Floxuridine; Fluorouracil; Hydroxyurea; Leucovorin; Leukemia L1210; Mice; Structure-Activity Relationship; Tumor Cells, Cultured | 1987 |
Formation of conjugates of 2-fluoro-beta-alanine and bile acids during the metabolism of 5-fluorouracil and 5-fluoro-2-deoxyuridine in the isolated perfused rat liver.
Topics: Alanine; Animals; beta-Alanine; Bile; Bile Acids and Salts; Chromatography, High Pressure Liquid; Floxuridine; Fluorouracil; Gas Chromatography-Mass Spectrometry; In Vitro Techniques; Liver; Male; Perfusion; Rats | 1988 |
[Comparative studies on the antitumor activity of the fluorinated pyrimidines 5'-DFUR, tegafur, UFT and FUra on various murine tumors].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Floxuridine; Fluorouracil; Leukemia P388; Liver Neoplasms, Experimental; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Neoplasms, Experimental; Sarcoma 180; Tegafur; Uracil | 1988 |
Biological activities of 5-fluorouracil and its prodrug 5'-deoxy-5-fluorouridine in rats.
Topics: Animals; Body Weight; Colonic Neoplasms; Drug Therapy; Female; Floxuridine; Fluorouracil; Prodrugs; Rats; Rats, Inbred Strains | 1987 |
Synthesis and interaction with uridine phosphorylase of 5'-deoxy-4',5-difluorouridine, a new prodrug of 5-fluorouracil.
Topics: Animals; Antineoplastic Agents; Floxuridine; Fluorouracil; Hydrolysis; Kinetics; Mice; Mice, Inbred DBA; Pentosyltransferases; Pharmaceutical Preparations; Prodrugs; Tumor Cells, Cultured; Uridine Phosphorylase | 1988 |
Comparison of the pyrimidine nucleoside phosphorylase activity in human tumors and normal tissues.
Topics: Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; In Vitro Techniques; Pentosyltransferases; Prodrugs; Pyrimidine Phosphorylases; Spectrophotometry; Stomach Neoplasms | 1988 |
Increased levels of DNA lesions induced by leucovorin-5-fluoropyrimidine in human colon adenocarcinoma.
Topics: Adenocarcinoma; Aphidicolin; Cell Line; Cell Survival; Colonic Neoplasms; Diterpenes; DNA; DNA Damage; Drug Synergism; Floxuridine; Fluorouracil; Humans; Leucovorin; Pyrimidines; Thymidine | 1988 |
Concentration and time dependence of the toxicity of fluorinated pyrimidines to HT 29 colorectal carcinoma cells.
Topics: Cell Line; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Humans; Rectal Neoplasms; Time Factors; Tumor Cells, Cultured; Uridine | 1988 |
Determination of 5-fluorouracil in plasma and liver after oral administration of 5'-deoxy-5-fluorouridine using gas chromatography-mass spectrometry.
Topics: Administration, Oral; Adult; Floxuridine; Fluorouracil; Gas Chromatography-Mass Spectrometry; Humans; Liver; Middle Aged | 1988 |
Intra-arterial hepatic chemotherapy for liver malignancy.
Topics: Floxuridine; Fluorouracil; Humans; Injections, Intra-Arterial; Liver Neoplasms | 1988 |
Mechanism of the cytotoxic synergism of fluoropyrimidines and folinic acid in mouse leukemic cells.
Topics: Animals; Cell Survival; Drug Synergism; Floxuridine; Fluorouracil; Kinetics; Leucovorin; Leukemia L1210; Mice; Thymidylate Synthase | 1988 |
Inhibition of thymidylate synthase after administration of doxifluridine in a transplantable colon carcinoma in the rat.
Topics: Animals; Carcinoma; Colonic Neoplasms; Female; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Male; Neoplasm Transplantation; Rats; Rats, Inbred Strains; Thymidylate Synthase | 1988 |
[Our therapy concept in nonresectable liver metastases].
Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Combined Modality Therapy; Female; Floxuridine; Fluorouracil; Humans; Infusion Pumps; Infusions, Intra-Arterial; Liver Neoplasms; Liver Transplantation; Male; Middle Aged; Mitomycin; Mitomycins | 1988 |
Enhancement of fluorinated pyrimidine-induced cytotoxicity by leucovorin in human colorectal carcinoma cell lines.
Topics: Carcinoma; Cell Survival; Colorectal Neoplasms; Drug Synergism; Floxuridine; Fluorouracil; Humans; Leucovorin; Tumor Cells, Cultured | 1988 |
[Rationale and current results of loco-regional chemotherapy in hepatic metastases of colorectal carcinoma].
Topics: Antineoplastic Agents; Carmustine; Cisplatin; Colorectal Neoplasms; Doxorubicin; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Methotrexate; Mitomycin; Mitomycins; Models, Biological; Prognosis | 1987 |
The in vitro stability of doxifluridine in whole blood and plasma.
Topics: Drug Stability; Floxuridine; Fluorouracil; Half-Life; Humans | 1988 |
Catabolism of 5-fluoro-2'-deoxyuridine by isolated rat intestinal epithelial cells.
Topics: Animals; Epithelium; Floxuridine; Fluorouracil; In Vitro Techniques; Intestinal Mucosa; Kinetics; Male; Pentosyltransferases; Pyrimidine Phosphorylases; Rats; Rats, Inbred Strains; Thymidine; Uracil | 1988 |
[Pharmacokinetic studies on 5-fluorouracil and its metabolite in rabbits by high pressure liquid chromatography].
Topics: Animals; Chromatography, High Pressure Liquid; Female; Floxuridine; Fluorouracil; Male; Rabbits; Species Specificity | 1988 |
A sensitive non-radioactive assay for pyrimidine nucleoside phosphorylase using reversed-phase high performance liquid chromatography.
Topics: Cell Line, Transformed; Chromatography, High Pressure Liquid; Floxuridine; Fluorouracil; Humans; Kinetics; Pentosyltransferases; Pyrimidine Phosphorylases; Tumor Cells, Cultured; Uracil; Uridine | 1988 |
The antiproliferative effects of fluoropyrimidine derivatives against human tumor xenografts in a subrenal capsule assay.
Topics: Animals; Antineoplastic Agents; Body Weight; Cell Division; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Male; Mice; Mice, Nude; Stomach Neoplasms; Subrenal Capsule Assay; Tegafur; Transplantation, Heterologous | 1988 |
Tumor cell responses to inhibition of thymidylate synthase.
Topics: Animals; Cell Line; Cell Survival; Drug Screening Assays, Antitumor; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Kinetics; Leucovorin; Protein Binding; Thymidylate Synthase; Tumor Cells, Cultured | 1988 |
Doxifluridine (5'-dFUrd) in patients with advanced colorectal carcinoma. A phase II study.
Topics: Angina Pectoris; Brain Diseases; Carcinoembryonic Antigen; Colonic Neoplasms; Drug Evaluation; Electromyography; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Peripheral Nervous System Diseases; Rectal Neoplasms | 1985 |
Combined use of drugs and radiation in the treatment of liver metastases.
Topics: Amifostine; Bromodeoxyuridine; Combined Modality Therapy; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Liver; Liver Neoplasms | 1986 |
5-Fluoro-5'-deoxyuridine is an inhibitor of uridylate nucleotidase in L1210 leukaemia.
Topics: 5'-Nucleotidase; Animals; Antimetabolites, Antineoplastic; Biotransformation; Cell Cycle; DNA, Neoplasm; Floxuridine; Fluorouracil; Leukemia L1210; Mice; Nucleotidases; Pentosyltransferases; Pyrimidine Phosphorylases; RNA, Neoplasm; Thymidylate Synthase | 1986 |
Elevation of plasma levels of fluorinated pyrimidines by guanosine 5'-monophosphate.
Topics: Animals; Deoxycytidine; Drug Interactions; Floxuridine; Fluorouracil; Guanine Nucleotides; Guanosine Monophosphate; Guanosine Triphosphate; Inosine Monophosphate; Male; Mice | 1987 |
Resistance of CCRF-CEM cloned sublines to 5-fluorodeoxyuridine associated with enhanced phosphatase activities.
Topics: Acid Phosphatase; Alkaline Phosphatase; Biological Transport; Clone Cells; Drug Resistance; Floxuridine; Fluorouracil; Humans; Leukemia; Thymidine Kinase; Thymidine Monophosphate | 1985 |
Studies on 18F-labeled pyrimidines III. Biochemical investigation of 18F-labeled pyrimidines and comparison with 3H-deoxythymidine in tumor-bearing rats and mice.
Topics: Animals; Floxuridine; Fluorouracil; Iron Radioisotopes; Liver Neoplasms, Experimental; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Neoplasms, Experimental; Pyrimidines; Radionuclide Imaging; Rats; Thymidine; Tissue Distribution; Tritium; Uridine | 1985 |
Treatment of hepatic metastases.
Topics: Chemotherapy, Cancer, Regional Perfusion; Combined Modality Therapy; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Liver Function Tests; Liver Neoplasms | 1985 |
Drug extravasation as a complication of venous access ports.
Topics: Adolescent; Adult; Aged; Dobutamine; Extravasation of Diagnostic and Therapeutic Materials; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Infusions, Parenteral; Male; Middle Aged; Necrosis; Punctures; Skin; Time Factors | 1985 |
[Experimental results of survivals with different dose schedule of 5-FU and 5'-DFUR].
Topics: Animals; Antineoplastic Agents; Drug Administration Schedule; Floxuridine; Fluorouracil; Lung Neoplasms; Male; Mice | 1985 |
Treatment of colorectal cancer hepatic metastases by hepatic artery chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carmustine; Colonic Neoplasms; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver; Liver Neoplasms; Mitomycins; Radionuclide Imaging; Rectal Neoplasms | 1985 |
Gas-liquid chromatographic analysis of fluoropyrimidine nucleosides and fluorouracil in plasma and urine.
Topics: Animals; Chromatography, Gas; Chromatography, Ion Exchange; Dogs; Floxuridine; Fluorouracil; Humans; Hydrogen-Ion Concentration; Kidney; Kinetics; Uridine | 1985 |
The degradation of 5'-deoxy-5-fluorouridine by pyrimidine nucleoside phosphorylase in normal and cancer tissues.
Topics: Animals; Colon; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Humans; Hydrogen-Ion Concentration; Intestine, Small; Kinetics; Lymph Nodes; Mice; Pentosyltransferases; Pyrimidine Phosphorylases; Spectrophotometry, Ultraviolet; Tissue Distribution | 1985 |
Systemic chemotherapy of mammary carcinoma.
Topics: Amines; Antineoplastic Agents; Azirines; Azo Compounds; Breast Neoplasms; Caproates; Carbohydrates; Chlorambucil; Cyclophosphamide; Evaluation Studies as Topic; Floxuridine; Fluorouracil; Humans; Imidazoles; Mercaptopurine; Methotrexate; Mitomycins; Palliative Care; Prednisone; Triazines; Vincristine | 1971 |
Intra-arterial infusion--an adjuvant to the treatment of oral carcinoma.
Topics: Adult; Aged; Carotid Artery, External; Catheterization; Evaluation Studies as Topic; Floxuridine; Fluorouracil; Gingival Neoplasms; Humans; Injections, Intra-Arterial; Leucovorin; Lip Neoplasms; Methotrexate; Middle Aged; Mouth Neoplasms; Palatal Neoplasms; Palliative Care | 1972 |
5-Fluoropyrimidine-resistant mutants of pneumococcus.
Topics: Carbon Isotopes; Chromatography, Thin Layer; Cytosine; Deoxyribonucleosides; Drug Resistance, Microbial; Floxuridine; Fluorine; Fluorouracil; Mutation; N-Glycosyl Hydrolases; Pentosyltransferases; Phosphoric Monoester Hydrolases; Phosphotransferases; Pyrimidines; Ribonucleosides; Streptococcus pneumoniae; Transformation, Genetic; Uridine | 1973 |
The treatment of hepatic metastases by long-term chemotherapeutic infusions.
Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Colonic Neoplasms; Evaluation Studies as Topic; Female; Floxuridine; Fluorouracil; Humans; Infusions, Parenteral; Liver Neoplasms; Male; Methods; Methotrexate; Middle Aged; Neoplasm Metastasis; Rectal Neoplasms | 1970 |
Maintenance of delayed hypersensitivity reactions in patients receiving cancer chemotherapy.
Topics: Cyclophosphamide; Female; Floxuridine; Fluorouracil; Humans; Hypersensitivity, Delayed; Immunity; Male; Neoplasm Metastasis; Neoplasms; Skin Tests | 1968 |
[Treatment of inoperable tumors by continuous and prolonged arterial perfusion of an antimitotic association].
Topics: Antineoplastic Agents; Catheterization; Chemotherapy, Cancer, Regional Perfusion; Floxuridine; Fluorouracil; Humans; Methotrexate; Mitomycins; Neoplasms; Palliative Care; Perfusion; Vinblastine; Vincristine | 1969 |
Cytochemical evaluation of metabolic inhibitors in cell culture.
Topics: Animals; Cell Division; Chloramphenicol; Culture Techniques; Dactinomycin; DNA; Floxuridine; Fluorouracil; Histocytochemistry; Mechlorethamine; Mitomycins; Neoplasms; Protein Biosynthesis; Puromycin; Radiation Effects; RNA; Spectrophotometry | 1965 |
Effect of fluoropyrimidines on delayed cutaneous hypersensitivity.
Topics: Floxuridine; Fluorouracil; Humans; Hypersensitivity, Delayed; Neoplasms; Pyrimidines; Skin Tests | 1965 |
Inhibition of plaque formation by myxoma and fibroma viruses with pyrimidine analogues.
Topics: Antiviral Agents; Benzimidazoles; Bromodeoxyuridine; Culture Techniques; Cytosine; DNA, Viral; Fibroma; Floxuridine; Fluorouracil; Idoxuridine; Mercaptopurine; Methotrexate; Myxoma virus; Nucleosides; Oncogenic Viruses; Thiosemicarbazones; Thymine | 1965 |
Congenital malformations produced in chickens by fluorinated pyrimidines.
Topics: Abnormalities, Drug-Induced; Animals; Antimetabolites; Chick Embryo; Floxuridine; Fluorouracil; Pyrimidines; Thymidine | 1966 |
Comparative responses of regulative and determinate embryos to metabolic inhibitors.
Topics: 5-Hydroxytryptophan; Amino Acids; Animals; Antimetabolites; Arginine; Canavanine; Chordata, Nonvertebrate; Dactinomycin; Echinodermata; Embryo, Nonmammalian; Floxuridine; Fluorouracil; In Vitro Techniques; Proteins; Puromycin; RNA; Tryptophan | 1965 |
Chemotherapy studies in an animal tumor spectrum. II. Sensitivity of tumors to fourteen antitumor chemicals.
Topics: Animals; Antineoplastic Agents; Arsenicals; Busulfan; Cyclophosphamide; Dactinomycin; Diethylstilbestrol; Floxuridine; Fluorouracil; Hydrocortisone; Mercaptopurine; Methotrexate; Mice; Mitomycins; Neoplasms, Experimental; Urethane; Vinblastine | 1966 |
Myeloid leukemia C-1498 as a screen for cancer chemotherapeutic agents.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Azaguanine; Azaserine; Busulfan; Cyclophosphamide; Dactinomycin; Female; Floxuridine; Fluorouracil; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice; Neoplasms, Experimental; Prednisone; Pyrazoles; Pyrimidines; Triethylenemelamine; Vinblastine; Vincristine | 1966 |
An evaluation of 51 patients with hepatic artery infusion.
Topics: Antineoplastic Agents; Catheterization; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Hepatic Artery; Humans; Injections, Intra-Arterial; Liver Neoplasms; Melphalan; Methotrexate; Neoplasm Metastasis | 1966 |
The effect of fluorouracil and fluorodeoxyuridine on the genetic recombination in Schizosaccharomyces pombe.
Topics: Ascomycota; Floxuridine; Fluorouracil; Genetics | 1966 |
The effect of nucleic acid synthesis inhibitors on the chlorophyll formation by etiolated bean leaves.
Topics: Azaguanine; Chlorophyll; Dactinomycin; Floxuridine; Fluorouracil; In Vitro Techniques; Mitomycins; Plants, Edible; Thiouracil; Thymidine; Uridine | 1966 |
Acridine orange fluorochroming and ultraviolet absorption of Staphylococcus aureus cells modified by unbalanced nucleic acid and cell wall synthesis.
Topics: Acridines; Aminopterin; Antimetabolites; Azaguanine; Cell Wall; DNA, Bacterial; Floxuridine; Fluorouracil; Microscopy, Fluorescence; Mitomycins; RNA, Bacterial; Staphylococcus; Ultraviolet Rays | 1966 |
The response in vitro, of continuous cultures of human lymphoblasts (CCRF-CEM cells) to chemotherapeutic agents.
Topics: Animals; Azaserine; Chloramphenicol; Culture Media; Culture Techniques; Cyclophosphamide; Cytarabine; Dactinomycin; Deoxyuridine; Floxuridine; Fluorouracil; Humans; Hydrocortisone; Lymphocytes; Mechlorethamine; Mercaptopurine; Methotrexate; Mitomycins; Puromycin; Thymidine; Triazines; Vincristine | 1967 |
Induction of inter- and intragenic mitotic recombination by fluorodeoxyuridine and fluorouracil in Aspergillus nidulans.
Topics: Aspergillus; Cytogenetics; Floxuridine; Fluorouracil; Genes | 1967 |
New concepts in chemotherapy of advanced gastrointestinal cancer.
Topics: Aged; Cyclophosphamide; Female; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Humans; Male; Methotrexate; Middle Aged | 1967 |
A deoxythymidine kinase-deficient mutant of Escherichia coli. I. Isolation and some properties.
Topics: Bromodeoxyuridine; Carbon Isotopes; Chromatography, Paper; Coliphages; Escherichia coli; Floxuridine; Fluorouracil; Mutation; Thymidine Kinase | 1967 |
Determinants of human tumor sensitivity to fluorinated pyrimidine chemotherapy.
Topics: DNA, Neoplasm; Floxuridine; Fluorouracil; Humans; In Vitro Techniques; Ligases; Neoplasm Metastasis; Neoplasms; Phosphotransferases; Thymidine; Thymidine Kinase; Uracil Nucleotides; Uridine | 1967 |
Infusion of fluorinated pyrimidines into hepatic artery for treatment of metastatic carcinoma of liver.
Topics: Adenocarcinoma; Catheterization; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Hepatic Artery; Humans; Infusions, Parenteral; Liver Neoplasms; Neoplasm Metastasis | 1967 |
Steroid induction of porphyrin synthesis in liver cell culture. II. The effects of heme, uridine diphosphate glucuronic acid, and inhibitors of nucleic acid and protein synthesis on the induction process.
Topics: Acetates; Amides; Animals; Azaserine; Azo Compounds; Chick Embryo; Culture Techniques; Cycloheximide; Dactinomycin; Floxuridine; Fluorine; Fluorouracil; Glucosamine; Glucose; Glucuronates; Hexosephosphates; Leucine; Liver; Mitomycins; Organometallic Compounds; Phenylalanine; Porphyrias; Porphyrins; Pregnanes; Puromycin; Uracil Nucleotides | 1968 |
Hepatic artery catheterization for chemotherapy.
Topics: Angiography; Catheterization; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Parenteral; Liver Neoplasms; Methods | 1968 |
Multiplication of meningopneumonitis organisms in white blood cells.
Topics: Animals; Chlamydia; Chlamydia Infections; Floxuridine; Fluorescent Antibody Technique; Fluorouracil; Kidney; Leukocytes; Liver; Mice; Phagocytosis; Rabbits; Spleen | 1968 |
[Effect of inhibitors of DNA synthesis on chlorophyll formation].
Topics: Chlorophyll; Chloroplasts; DNA; Floxuridine; Fluorouracil; Mitomycins; Plants; RNA | 1966 |
Determination of certain antitumor agents in mouse blood by microbiologic assay.
Topics: Anilides; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Biological Assay; Floxuridine; Fluorouracil; Mercaptopurine; Methods; Methotrexate; Mice | 1968 |
Radiosensitization of brain tumor cells with a thymidine analogue (bromouridine).
Topics: Astrocytoma; Brain Neoplasms; Bromodeoxyuridine; Culture Techniques; DNA; Floxuridine; Fluorouracil; Follow-Up Studies; Glioma; Humans; Meningioma; Methotrexate; Oligodendroglioma; Radiation-Sensitizing Agents; Thymidine | 1968 |
The use of uterine vascular clamping in the pregnant rat to modify the embryotoxic effects of anticancer drugs.
Topics: Aminopterin; Animals; Chemotherapy, Cancer, Regional Perfusion; Female; Fetus; Floxuridine; Fluorouracil; Maternal-Fetal Exchange; Methods; Nitrogen Mustard Compounds; Pregnancy; Pregnancy, Animal; Rats; Time Factors; Uterus | 1968 |
Responses of freshly cultured tumour cells to certain selected chemotherapeutic agents.
Topics: Adenocarcinoma; Antineoplastic Agents; Chlorambucil; Colchicine; Culture Techniques; Cyclophosphamide; Dactinomycin; Female; Floxuridine; Fluorouracil; Hodgkin Disease; Humans; Melphalan; Mercaptopurine; Methotrexate; Nandrolone; Neoplasms; Nitrogen Mustard Compounds; Norethindrone; Prednisolone; Progesterone; Testosterone; Thiotepa; Uterine Neoplasms; Vinblastine | 1968 |
The value of fluorinated pyrimidines in advanced malignancy.
Topics: Adult; Breast Neoplasms; Colonic Neoplasms; Diarrhea; Female; Floxuridine; Fluorouracil; Humans; Leukocyte Count; Male; Middle Aged; Neoplasms; Stomach Neoplasms; Ulcer | 1968 |
Perfusion and infusion chemotherapy for cancer of the head and neck.
Topics: Antineoplastic Agents; Bromodeoxyuridine; Carotid Arteries; Catheterization; Chemotherapy, Cancer, Regional Perfusion; Cyclophosphamide; Dactinomycin; DNA; Floxuridine; Fluorouracil; Head; Humans; Infusions, Parenteral; Melphalan; Methods; Neck; Nitrogen Mustard Compounds | 1964 |
Protracted intra-arterial chemotherapy with sequential courses of antimitotics and hydrogen peroxyde in the treatment of head and neck tumors.
Topics: Antineoplastic Agents; Catheterization; Floxuridine; Fluorouracil; Head and Neck Neoplasms; Humans; Hydrogen Peroxide; Injections, Intra-Arterial; Methods; Methotrexate; Mitomycins; Mitosis; Mouth Neoplasms; Nitrogen Mustard Compounds; Oxygen Inhalation Therapy; Perfusion; Stimulation, Chemical | 1969 |
[Comparative in vitro studies with 5-fluorouracil and some of its derivatives].
Topics: Acyltransferases; Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Cell-Free System; Depression, Chemical; DNA Nucleotidyltransferases; DNA, Neoplasm; Floxuridine; Fluorine; Fluorouracil; In Vitro Techniques; Leucine; Neoplasm Proteins; Nucleotides; RNA, Neoplasm; Thymidine; Uridine | 1969 |
Enzymatic determinants of responsiveness of the LPC-1 plasma cell neoplasm to fluorouracil and fluorodeoxyuridine.
Topics: Animals; Cell Line; Disease Models, Animal; Floxuridine; Fluorouracil; Intestinal Neoplasms; Mice; Neoplasms, Experimental; Nucleotides; Phosphotransferases; Plasmacytoma; Thymidine Kinase; Transferases; Uridine | 1970 |
Determinants of responsiveness to 5-fluorouridine in transplantable murine leukemias.
Topics: Animals; Antineoplastic Agents; Biodegradation, Environmental; Biological Transport; Cell Line; Cell Survival; Cells, Cultured; Deoxyuridine; DNA Replication; DNA, Neoplasm; Drug Resistance; Floxuridine; Fluorine; Fluorouracil; Leukemia, Experimental; Mice; Neoplasm Transplantation; Pentosyltransferases; Phosphotransferases; Uridine | 1971 |
Nucleic acid related compounds. 3. A facile synthesis of 5-fluorouracil bases and nucleosides by direct fluorination.
Topics: Floxuridine; Fluorouracil; Methods; Methylation; Nucleic Acids; Nucleosides; Pyrimidines | 1971 |
The effect of a series of anti-cancer drugs on plasma cholinesterase activity.
Topics: Antineoplastic Agents; Benzoates; Choline; Cholinesterase Inhibitors; Cholinesterases; Cyclophosphamide; Dactinomycin; Floxuridine; Fluorouracil; Humans; Hydrolysis; In Vitro Techniques; Mechlorethamine; Procaine; Thiotepa; Triethylenemelamine; Vinblastine; Vincristine | 1972 |
The physiological disposition of 5-fluorouracil in mice bearing solid L1210 lymphocytic leukemia.
Topics: Animals; Bone Marrow; Brain; Carbon Isotopes; Cerebellum; Chromatography, Ion Exchange; Chromatography, Thin Layer; Cytosine Nucleotides; Floxuridine; Fluorouracil; Intestine, Small; Kidney; Leukemia L1210; Liver; Medulla Oblongata; Mice; Spleen; Uracil Nucleotides | 1972 |
Metabolism of pyrimidines and pyrimidine nucleosides by Salmonella typhimurium.
Topics: Aminohydrolases; Cytidine; Cytosine; Deoxyuridine; Floxuridine; Flucytosine; Fluorouracil; Genetics, Microbial; Genotype; Mutation; Nucleosides; Nucleotidyltransferases; Pentosyltransferases; Phosphotransferases; Pyrimidines; Salmonella typhimurium; Thymidine; Uracil; Uracil Nucleotides; Uridine | 1972 |
Chemotherapy of cancer of the colon and rectum.
Topics: Antineoplastic Agents; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; Nitrosourea Compounds; Rectal Neoplasms; Thiotepa | 1972 |
Practical aspects of investigation and treatment of colorectal cancer.
Topics: Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Infusions, Parenteral; Liver Function Tests; Liver Neoplasms; Lymphatic Metastasis; Male; Methotrexate; Neoplasm Metastasis; Proctoscopy; Prognosis; Rectal Neoplasms; Sex Factors | 1972 |
Chemotherapy of colon and rectal cancer.
Topics: Administration, Oral; Antigens, Neoplasm; Chemotherapy, Cancer, Regional Perfusion; Colonic Neoplasms; Drug Combinations; Floxuridine; Fluorouracil; Humans; Neoplasm Metastasis; Rectal Neoplasms | 1972 |
5-Fluorouracil and derivatives in cancer chemotherapy. II. Possible in vivo formation and stabilization of 5-fluoro-2'-deoxyuridine.
Topics: Biopharmaceutics; Biotransformation; Chromatography, Thin Layer; Deoxyuridine; Dialysis; Drug Stability; Floxuridine; Fluorouracil; Humans; Neoplasms; Spectrophotometry, Ultraviolet | 1972 |
Effect of resection of the primary neoplasm on responsiveness to chemotherapy of patients with large bowel cancer.
Topics: Adenocarcinoma; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; Nitrosourea Compounds; Rectal Neoplasms | 1972 |
Chemotherapy of gastrointestinal cancer.
Topics: Antineoplastic Agents; Colonic Neoplasms; Esophageal Neoplasms; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Humans; Prognosis; Rectal Neoplasms; Stomach Neoplasms | 1972 |
Comparison of the effects of several inhibitors of the synthesis of nucleic acids upon the viability and progression through the cell cycle of cultured H. Ep. no. 2 cells.
Topics: Antimetabolites; Azaguanine; Carcinoma; Cell Division; Cell Line; Cell Survival; Cytarabine; DNA Replication; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Humans; Hydroxyurea; Laryngeal Neoplasms; Mercaptopurine; Methotrexate; Mitosis; Ribonucleosides; Thioguanine; Time Factors; Tritium | 1972 |
Incorporation of thymidine after administration of fluorouracil and fluorouridine to adult and embryo mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Cleft Palate; Dose-Response Relationship, Drug; Embryo, Mammalian; Female; Fetus; Floxuridine; Fluorine; Fluorouracil; Mice; Mice, Inbred Strains; Pregnancy; Rats; Thymidine; Time Factors; Tritium; Uridine | 1971 |
Distribution of 5-fluorouracil-2- 14 C and its metabolites in a murine glioma.
Topics: Animals; Brain; Brain Neoplasms; Carbon Isotopes; Chromatography, Ion Exchange; Chromatography, Thin Layer; Ependymoma; Floxuridine; Fluorouracil; Glioma; Half-Life; Injections, Intraperitoneal; Kinetics; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Propionates; Time Factors; Uracil Nucleotides | 1972 |
Incorporation of idoxuridine analogs into corneal herpes simplex virus.
Topics: Animals; Autoradiography; Bromodeoxyuridine; Cornea; DNA, Viral; Epithelium; Floxuridine; Fluorouracil; Herpes Simplex; Idoxuridine; Keratitis, Dendritic; Ophthalmic Solutions; Rabbits; Thymidine; Tritium; Uracil | 1972 |
Enhancement of the antitumor activity of 5-fluorouracil by drug combinations.
Topics: Animals; Body Weight; Carcinoma, Ehrlich Tumor; Cell Count; Floxuridine; Fluorouracil; Hydroxyurea; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Time Factors; Transplantation, Homologous; Vinblastine | 1973 |
Complex formation of uracil, 2'-deoxyuridine and their 5-halogenated derivatives.
Topics: Bromodeoxyuridine; Bromouracil; Chemical Phenomena; Chemistry; Copper; Deoxyuridine; Drug Stability; Floxuridine; Fluorouracil; Idoxuridine; Mathematics; Nickel; Potentiometry; Silver; Uracil | 1973 |
The nucleotides of fluorinated pyrimidines and their biological activities.
Topics: Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Cells, Cultured; Chromatography, Ion Exchange; Floxuridine; Fluorine; Fluorouracil; Formates; HeLa Cells; Kinetics; Mice; Models, Biological; Pyrimidine Nucleotides; Pyrimidines; RNA; Structure-Activity Relationship; Thymidylate Synthase; Thymine; Vaccinia virus | 1971 |
Regional arterial chemotherapy for advanced carcinoma of the head and neck. A ten-year review.
Topics: Antimetabolites; Antineoplastic Agents; Carotid Arteries; Catheterization; Digestive System; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Head; Head and Neck Neoplasms; Humans; Infusions, Parenteral; Methotrexate; Neoplasms; Remission, Spontaneous | 1973 |
5-Fluorouracil and derivatives in cancer chemotherapy. 3. In vivo enhancement of antitumor activity of 5-fluorouracil (FU) and 5-fluoro-2'-deoxyuridine (FUDR).
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Chromatography, Thin Layer; Deoxycytidine; Deoxyuridine; Dialysis; Drug Synergism; Drug Therapy, Combination; Floxuridine; Fluorouracil; Leukemia L1210; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Neoplasms, Experimental; Transplantation, Homologous | 1973 |
Adenocarcinomas of stomach, pancreas, liver, and biliary tracts. Survival of 328 patients treated with fluoropyrimidine therapy.
Topics: Adenocarcinoma; Antineoplastic Agents; Bile Duct Neoplasms; Evaluation Studies as Topic; Floxuridine; Fluorouracil; Follow-Up Studies; Gallbladder Neoplasms; Humans; Liver Neoplasms; Pancreatic Neoplasms; Stomach Neoplasms | 1974 |
Regional infusion chemotherapy of hepatic metastases from carcinoma of the colon.
Topics: Age Factors; Aspartate Aminotransferases; Catheterization; Chemotherapy, Cancer, Regional Perfusion; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Injections, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Prognosis; Radiography; Radionuclide Imaging; Remission, Spontaneous; Time Factors | 1974 |
Assay of 5-fluorodeoxyuridine 5'-monophosphate deoxyuridine 5'-monophosphate pools following 5-fluorouracil.
Topics: Animals; Cell Line; Clinical Enzyme Tests; Deoxyuridine; Depression, Chemical; DNA, Neoplasm; Floxuridine; Fluorouracil; Hydrogen-Ion Concentration; Lacticaseibacillus casei; Mice; Neoplasms, Experimental; Phosphates; Thymidylate Synthase | 1974 |
Application of gas chromatography-chemical ionization mass fragmentography in the evaluation of bases and nucleoside analogues used in cancer chemotherapy.
Topics: Animals; Antineoplastic Agents; Base Sequence; Chromatography, Gas; Cytarabine; Drug Evaluation; Floxuridine; Fluorouracil; Mass Spectrometry; Mercaptopurine; Methods; Methylation; Mice; Nucleosides; Purines; Pyrimidines; Ribonucleosides | 1974 |
R factor elimination by inhibitors of thymidylate synthetase (fluorodeoxyuridine and showdomycin) and the occurrence of single strand breaks in plasmid DNA.
Topics: Antibiotics, Antineoplastic; DNA, Bacterial; Drug Resistance, Microbial; Escherichia coli; Extrachromosomal Inheritance; Floxuridine; Fluorouracil; Genetics, Microbial; Methyltransferases; Molecular Biology; Nucleosides; Thymidine; Uracil Nucleotides | 1974 |
Infusion of liver tumours.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Chemotherapy, Cancer, Regional Perfusion; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Liver Neoplasms; Methotrexate; Neoplasm Metastasis; Radioisotopes | 1968 |
Considerations in the development of a predictive system for cancer chemotherapy.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line; DNA; Floxuridine; Fluorouracil; Liver Neoplasms; Neoplasms, Experimental; Nucleosides; Thymine | 1971 |
Experience with hepatic arterial infusions.
Topics: Adult; Aged; Bile Duct Neoplasms; Carcinoma, Hepatocellular; Female; Floxuridine; Fluorouracil; Gallbladder Neoplasms; Hepatic Artery; Humans; Injections, Intra-Arterial; Intestinal Neoplasms; Liver Neoplasms; Male; Middle Aged; Neoplasm Metastasis | 1971 |
Inhibitory effects and metabolism of 5-fluoropyrimidine derivatives in pneumococcus.
Topics: Aluminum; Autoradiography; Bacterial Proteins; Bacteriological Techniques; Carbon Isotopes; Cell-Free System; Chemical Precipitation; Chromatography, Ion Exchange; Chromatography, Thin Layer; Colorimetry; Culture Media; Cytosine; DNA, Bacterial; Filtration; Floxuridine; Fluorouracil; Freezing; Microscopy, Phase-Contrast; Nucleotidyltransferases; Oxides; Pyrimidinones; RNA, Bacterial; Streptococcus pneumoniae; Thymidine; Trichloroacetic Acid | 1971 |
[Determination, properties and inhibition of thymidilate synthetase in immature myeloid blood and bone marrow cells].
Topics: Bone Marrow; Bone Marrow Cells; Floxuridine; Fluorouracil; Folic Acid Antagonists; Humans; Hydrogen-Ion Concentration; Ions; Leukocytes; Magnesium; Mercaptoethanol; Methyltransferases; NADP; Transferases; Tritium; Uracil Nucleotides | 1971 |
The effect of pre-inhibition of DNA synthesis in continuous human amniotic cell culture (strain FL) on adenovirus type 5 reproduction.
Topics: Adenoviridae; Aminopterin; Amnion; Animals; Antigens; Autoradiography; Cell Line; Cell Nucleus; Cells, Cultured; DNA; Floxuridine; Fluorescent Antibody Technique; Fluorouracil; Humans; Immune Sera; Rabbits; Radiation Effects; Thymidine; Time Factors; Tritium; Ultraviolet Rays; Virus Replication | 1969 |
A minicolony assay for the viability of mammalian cells in vitro.
Topics: Agar; Animals; Cell Aggregation; Cell Count; Cell Division; Culture Media; Culture Techniques; Floxuridine; Fluorouracil; L Cells; Life Support Systems; Mice; Time Factors; Vinblastine | 1968 |
[Intra-arterial chemotherapy using an implantable infusion pump in liver metastases of colorectal tumors and hepatomas].
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Colonic Neoplasms; Doxorubicin; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Prognosis; Rectal Neoplasms | 1984 |
The effect of 5-fluorouracil and 5-fluorocytosine on the development of the filarial nematodes Brugia pahangi and Dirofilaria immitis.
Topics: Animals; Brugia; Cytosine; Dirofilaria immitis; Female; Filariasis; Filarioidea; Floxuridine; Flucytosine; Fluorouracil; Male; Microfilariae | 1981 |
5-fluorouracil-methotrexate synergy: enhancement of 5-fluorodeoxyridylate binding to thymidylate synthase by dihydropteroylpolyglutamates.
Topics: Animals; Cell Survival; Drug Synergism; Floxuridine; Fluorouracil; Folic Acid; Leukemia L1210; Methotrexate; Methyltransferases; Polyglutamic Acid; Protein Binding; Pteroylpolyglutamic Acids; Thymidylate Synthase | 1980 |
Selective activation of 5'-deoxy-5-fluorouridine by tumor cells as a basis for an improved therapeutic index.
Topics: Animals; Biotransformation; Bone Marrow; Carcinoma, Ehrlich Tumor; Cells, Cultured; Floxuridine; Fluorouracil; Mice; RNA; Thymidylate Synthase | 1981 |
Comparison of the reversed-phase high-performance liquid chromatographic separations of fluoropyrimides, pyrimidines, and purines.
Topics: Chromatography, High Pressure Liquid; Floxuridine; Fluorouracil; Indicators and Reagents; Purines; Pyrimidines; Structure-Activity Relationship | 1982 |
Reversed-phase ion-pair high-performance liquid chromatographic assay of 5-fluorouracil, 5'-deoxy-5-fluorouridine, their nucleosides, mono-, di-, and triphosphate nucleotides with a mixture of quaternary ammonium ions.
Topics: Chromatography, High Pressure Liquid; Deoxyuracil Nucleotides; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Isomerism; Structure-Activity Relationship; Uracil Nucleotides; Uridine | 1982 |
Clinical pharmacological studies of concurrent infusion of 5-fluorouracil and thymidine in treatment of colorectal carcinomas.
Topics: Colonic Neoplasms; Drug Therapy, Combination; Floxuridine; Fluorouracil; Humans; Infusions, Parenteral; Rectal Neoplasms; Thymidine; Thymine | 1982 |
Intra-arterial chemotherapy using an implantable infusion pump and liver irradiation for the treatment of hepatic metastases.
Topics: Adult; Aged; Bone Neoplasms; Chemotherapy, Cancer, Regional Perfusion; Colonic Neoplasms; Drug Administration Schedule; Floxuridine; Fluorouracil; Gastrointestinal Diseases; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Lung Neoplasms; Middle Aged; Thrombocytopenia | 1982 |
5-Fluorouracil incorporation in DNA of human breast carcinoma cells.
Topics: Breast Neoplasms; Cell Line; DNA Replication; DNA, Neoplasm; Female; Floxuridine; Fluorouracil; Humans; Kinetics; Phosphorus Radioisotopes; Thymidine; Tritium | 1982 |
Modulation of 1-beta-D-arabinofuranosylcytosine metabolism and cytotoxicity in L1210 cells by fluoropyrimidine pretreatment.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Cell Line; Cell Survival; Clone Cells; Cytarabine; Deoxyribonucleotides; Deoxyuridine; Drug Interactions; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Leukemia L1210; Mice; Uridine | 1982 |
Biochemical pharmacology in medical oncology.
Topics: Antineoplastic Agents; Cisplatin; Doxorubicin; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Infusions, Parenteral; Neoplasms; Pharmacology, Clinical | 1981 |
The potential for clinical application of in vitro assays predicting 5-FU sensitivity in man.
Topics: Breast Neoplasms; Cell-Free System; Cytosol; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; In Vitro Techniques; Phosphorylation; Uridine | 1981 |
Quantitative analysis of 5-fluorouracil and 5,6-dihydrofluorouracil in plasma by gas chromatography mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Floxuridine; Fluorouracil; Gas Chromatography-Mass Spectrometry; Humans; Time Factors; Uracil | 1982 |
Intraarterial infusion chemotherapy in the treatment of liver metastases from ovarian cancer.
Topics: Antineoplastic Agents; Cystadenocarcinoma; Doxorubicin; Drug Therapy, Combination; Endometriosis; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Middle Aged; Ovarian Neoplasms; Vincristine | 1981 |
Nucleotide levels and incorporation of 5-fluorouracil and uracil into DNA of cells treated with 5-fluorodeoxyuridine.
Topics: Deoxyribonucleotides; DNA; Floxuridine; Fluorouracil; Humans; Lymphocytes; Uracil; Uracil Nucleotides | 1982 |
Evidence that 5'-deoxy-5-fluorouridine may not be activated by the same mechanism as 5-fluorouracil.
Topics: Animals; Biotransformation; Cells, Cultured; Floxuridine; Fluorouracil; Inosine; Liver Neoplasms, Experimental | 1982 |
Therapeutic response of leukemic mice treated with fluorinated pyrimidines and inhibitors of deoxyuridylate synthesis.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chick Embryo; Cytosol; Deoxyuracil Nucleotides; Floxuridine; Fluorouracil; Leukemia L1210; Leukemia, Experimental; Mice; Phosphorylation; Pyrimidines; Ribonucleotide Reductases | 1982 |
Studies on the designing of chemotherapy for gastric cancer in man, based on the tumor tissue concentration of anticancer agents.
Topics: Antineoplastic Agents; Floxuridine; Fluorouracil; Gastric Mucosa; Humans; Stomach Neoplasms; Tegafur | 1982 |
Human leukemic cells resistant to 5-fluoro-2'-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides.
Topics: Cell Line; Deoxyribonucleotides; Drug Resistance; Floxuridine; Fluorouracil; Humans; Kinetics; Leukemia, Lymphoid; Methyltransferases; Protein Binding; Thymidylate Synthase | 1983 |
Mode of action of 5-fluorocytosine and 5-fluorouracil in dematiaceous fungi.
Topics: Cytosine; Drug Resistance, Microbial; Floxuridine; Flucytosine; Fluorouracil; Mitosporic Fungi; RNA, Fungal; RNA, Ribosomal; Species Specificity; Uridine | 1983 |
Differential selectivity of 5-fluorouracil and 5'-deoxy-5-fluorouridine in cultured human B lymphocytes and mouse L1210 leukemia.
Topics: Animals; Antineoplastic Agents; Ascitic Fluid; B-Lymphocytes; Biotransformation; Cell Division; Cells, Cultured; DNA; Female; Floxuridine; Fluorouracil; Humans; Leukemia L1210; Mice; Mice, Inbred DBA; Uridine Phosphorylase | 1983 |
5'-Deoxy-5-fluorouridine selective toxicity for human tumor cells compared to human bone marrow.
Topics: Antineoplastic Agents; Bone Marrow; Breast Neoplasms; Cell Survival; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; Leukemia, Myeloid, Acute; Neoplasms; Osteosarcoma | 1983 |
Decreased immunosuppression associated with antitumor activity of 5-deoxy-5-fluorouridine compared to 5-fluorouracil and 5-fluorouridine.
Topics: Animals; Antineoplastic Agents; Cell Survival; Female; Floxuridine; Fluorouracil; Immunosuppression Therapy; Inflammation; Male; Mice; Mice, Inbred C57BL; Pyrans; Thioglycolates; Uridine | 1983 |
[Pharmacological and pharmacodynamic aspects of cancer chemotherapy, with special reference to 5-fluorouracil and its derivatives].
Topics: Antineoplastic Combined Chemotherapy Protocols; Drug Combinations; Floxuridine; Fluorouracil; Humans; Kinetics; Neoplasms; Tegafur; Uracil | 1982 |
Studies on 18F-labeled pyrimidines. Tumor uptakes of 18F-5-fluorouracil, 18F-5-fluorouridine, and 18F-5-fluorodeoxyuridine in animals.
Topics: Animals; Autoradiography; Floxuridine; Fluorine; Fluorouracil; Liver Neoplasms, Experimental; Male; Radioisotopes; Rats; Rats, Inbred Strains; Tissue Distribution; Tomography, Emission-Computed; Uridine | 1983 |
Effective retreatment of patients with colorectal cancer and liver metastases.
Topics: Adenocarcinoma; Antibiotics, Antineoplastic; Antineoplastic Agents; Colonic Neoplasms; Drug Resistance; Drug Therapy, Combination; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Mitomycin; Mitomycins; Postoperative Complications | 1983 |
Chemical cholecystitis associated with hepatic artery infusion chemotherapy.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Arteries; Cholecystitis; Female; Floxuridine; Fluorouracil; Gallbladder; Hepatic Artery; Humans; Infusions, Intra-Arterial; Male; Middle Aged; Mitomycin; Mitomycins; Radiography | 1983 |
Enhancement of the incorporation of 5-fluorodeoxyuridylate into DNA of HL-60 cells by metabolic modulations.
Topics: Cell Line; Deoxyuracil Nucleotides; DNA Replication; DNA, Neoplasm; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Kinetics; Leukemia, Myeloid, Acute; Methotrexate; Thymidine; Tritium | 1983 |
Pharmacokinetic studies of 5-fluorouracil and 5'-deoxy-5-fluorouridine in rats.
Topics: Animals; Chromatography, High Pressure Liquid; Colonic Neoplasms; Dimethylhydrazines; Female; Floxuridine; Fluorouracil; Kidney; Kinetics; Neoplasm Transplantation; Protein Binding; Rats; Rats, Inbred F344; Time Factors | 1983 |
Simultaneous analysis of 5'-deoxy-5-fluorouridine and 5-fluorouracil in plasma by analytical isotachophoresis.
Topics: Electrophoresis; Floxuridine; Fluorouracil; Humans | 1983 |
Intra-arterial infusion in tumors of the pelvis.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Floxuridine; Fluorouracil; Humans; Iliac Artery; Infusions, Intra-Arterial; Leucovorin; Male; Melanoma; Methotrexate; Middle Aged; Ovarian Neoplasms; Pelvic Neoplasms; Prostatic Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms | 1983 |
Prolonged and continuous percutaneous intra-arterial hepatic infusion chemotherapy in advanced metastatic liver adenocarcinoma from colorectal primary.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Combined Modality Therapy; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Prognosis; Rectal Neoplasms | 1983 |
Intrahepatic chemotherapy in isolated liver metastases.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carmustine; Dacarbazine; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Prognosis; Vincristine | 1983 |
[Local infusion therapy in liver metastases of colorectal cancers. Results of a phase-II study].
Topics: Catheters, Indwelling; Colonic Neoplasms; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Parenteral; Life Expectancy; Liver Neoplasms; Rectal Neoplasms; Umbilical Veins | 1984 |
Regional chemotherapy: application in hepatic metastases.
Topics: Antineoplastic Agents; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms | 1984 |
Studies on 18F-labeled pyrimidines. II. Metabolic investigation of 18F-5-fluorouracil, 18F-5-fluoro-2'-deoxyuridine and 18F-5-fluorouridine in rats.
Topics: Animals; Bile; Floxuridine; Fluorine; Fluorouracil; Radioisotopes; Rats; Rats, Inbred Strains; Uridine | 1984 |
Tumor specific conversion of a pyrimidine antimetabolite.
Topics: Animals; Antineoplastic Agents; Cell Line; Floxuridine; Fluorouracil; Isomerism; Mice; Neoplasms, Experimental | 1984 |
31P-topical nuclear magnetic resonance (31P-TMR) studies of cardiotoxic effects of 5-fluorouracil (5-FU) and 5'-deoxy-5-fluorouridine (5'-DFUR).
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Electrocardiography; Floxuridine; Fluorouracil; Guinea Pigs; Heart; Magnetic Resonance Spectroscopy; Male; Myocardium; Phosphocreatine | 1984 |
5-fluorouracil and 5-fluoro-2'-deoxyuridine follow different metabolic pathways in the induction of cell lethality in L1210 leukaemia.
Topics: Animals; Cell Survival; Cells, Cultured; DNA, Neoplasm; Floxuridine; Fluorouracil; Isomerism; Leukemia L1210; Thymidine Monophosphate; Uridine Triphosphate | 1984 |
Rate-limiting steps in the interactions of fluoropyrimidines and methotrexate.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; Deoxyuridine; DNA, Neoplasm; Drug Interactions; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Methotrexate; Mice; Neoplasm Proteins; RNA, Neoplasm; Thymidine Monophosphate | 1984 |
Occurrence of induced 6-thioguanine-resistant colonies in synchronized V79 cells after treatment with ftorafur. Effects of the S9 fraction.
Topics: Animals; Cell Cycle; Cell Line; Cricetinae; Drug Resistance; Floxuridine; Fluorouracil; Male; Microsomes, Liver; Mutation; Tegafur; Thioguanine | 1984 |
Effect of guanosine on antitumor activity of fluorinated pyrimidines against P 388 leukemia.
Topics: Animals; Antineoplastic Agents; Drug Synergism; Floxuridine; Fluorouracil; Guanosine; Leukemia P388; Leukemia, Experimental; Male; Mice; Mice, Inbred Strains; Nucleosides; Uridine | 1984 |
[5'-Deoxy-5-fluorouridine enzymatic activation from the masked compound to 5-fluorouracil in human malignant tissues].
Topics: Administration, Oral; Aged; Animals; Antineoplastic Agents; Enzyme Activation; Female; Floxuridine; Fluorouracil; Humans; Infusions, Parenteral; Liver Neoplasms; Lung Neoplasms; Male; Mice; Neoplasms; Pentosyltransferases; Pyrimidine Phosphorylases; Sarcoma, Experimental; Stomach Neoplasms; Uridine Phosphorylase; Uterine Neoplasms | 1984 |
[Measurement of 5'-deoxy-5-fluorouridine (5'-DFUR) by high-performance liquid chromatography and studies on pharmacokinetics of 5'-DFUR and 5-fluorouracil by oral and intravenous administration].
Topics: Administration, Oral; Aged; Chromatography, High Pressure Liquid; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Injections, Intravenous; Kinetics; Male; Middle Aged; Stomach Neoplasms | 1984 |
[Development of fluoropyrimidine derivatives].
Topics: Animals; DNA Replication; Floxuridine; Fluorouracil; Mice; Phosphorylation; Pyrimidine Nucleotides; Rats; Sarcoma, Experimental; Tegafur; Uracil | 1984 |
Prognostic factors and in vitro cytotoxic sensitivity in colorectal cancer.
Topics: Antineoplastic Agents; Cell Division; Cell Survival; Cells, Cultured; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; Neoplasm Staging; Prognosis; Rectal Neoplasms; Thymidine; Tumor Stem Cell Assay | 1984 |
Syntheses of 18F-labeled pyrimidines and their usefulness for tumor imaging.
Topics: Animals; Chromatography, High Pressure Liquid; Floxuridine; Fluorine; Fluorouracil; Glioma; Liver Neoplasms, Experimental; Mammary Neoplasms, Experimental; Mice; Radioisotope Dilution Technique; Radioisotopes; Radionuclide Imaging; Rats; Uridine | 1984 |
Modulation of fluoropyrimidine cytotoxicity by methotrexate or 5-methyltetrahydrofolate in human leukemia cells in vitro.
Topics: Cells, Cultured; Drug Synergism; Floxuridine; Fluorouracil; Humans; Leukemia; Methotrexate; Tetrahydrofolates | 1984 |
Metabolism and biological activity of 5'-deoxy-5-fluorouridine, a novel fluoropyrimidine.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cells, Cultured; Chromatography, Liquid; Floxuridine; Fluorouracil; Male; Mice; Neoplasm Transplantation; Phosphotransferases; Structure-Activity Relationship; Thymidylate Synthase | 1980 |
[Completely implantable infusion pump. A new therapeutic possibility for selected patients with liver tumors].
Topics: Carcinoma, Hepatocellular; Catheters, Indwelling; Colonic Neoplasms; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Neoplasm Metastasis; Prostheses and Implants; Rectal Neoplasms | 1983 |
Surgical considerations in the management of hepatic neoplasia.
Topics: Adenoma, Bile Duct; Antineoplastic Agents; Carcinoma, Hepatocellular; Catheterization; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Ligation; Liver Circulation; Liver Neoplasms; Liver Transplantation; Portal Vein; Radionuclide Imaging | 1983 |
Potentiation of antitumor activity of 5-fluoro-2'-deoxyuridine by guanosine-5'-monophosphate.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclic GMP; Drug Synergism; Floxuridine; Fluorouracil; Leukemia P388; Male; Mice; Mice, Inbred Strains | 1984 |
On the mechanism of cytotoxicity of fluorinated pyrimidines in four human colon adenocarcinoma xenografts maintained in immune-deprived mice.
Topics: Adenocarcinoma; Animals; Cell Survival; Colonic Neoplasms; Female; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Male; Mice; Mice, Inbred CBA; Neoplasm Transplantation; Neoplasms, Experimental; Transplantation, Heterologous; Uridine | 1980 |
Effects of thymidine and thymidine plus 5-fluorouracil on the growth kinetics of a human lymphoid cell line.
Topics: Cell Cycle; Cell Division; Cell Line; Cell Survival; DNA Replication; Floxuridine; Fluorouracil; Humans; Thymidine; Thymine | 1980 |
Isolation of a cellular subpopulation from a human colonic carcinoma cell line.
Topics: Animals; Carcinoembryonic Antigen; Cell Division; Cell Line; Cells, Cultured; Colonic Neoplasms; Drug Resistance; Floxuridine; Fluorouracil; Humans; Mice; Microscopy, Electron; Neoplasm Transplantation | 1980 |
Hepatic arterial infusion chemotherapy for cancer of the liver.
Topics: Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms | 1980 |
Role of uridine phosphorylase for antitumor activity of 5'-deoxy-5-fluorouridine.
Topics: Animals; Biotransformation; Floxuridine; Fluorouracil; Leukemia L1210; Male; Mice; Pentosyltransferases; Sarcoma 180; Tegafur; Thymidine; Uridine; Uridine Phosphorylase | 1980 |
Combined effects of methotrexate and 5-fluoropyrimidine on human breast cancer cells in serum-free culture.
Topics: Breast Neoplasms; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Floxuridine; Fluorouracil; Humans; Methotrexate | 1980 |
A sensitive method for determination of 5-fluorouracil and 5-fluoro-2'-deoxyuridine in human plasma by high-pressure liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Floxuridine; Fluorouracil; Humans; Methods; Microchemistry | 1980 |
[Genetic control of pathways of pyrimidine metabolism in Aspergillus nidulans. 1. Isolation and genetic analysis of 6-azauracil resistant mutants].
Topics: Aspergillus nidulans; Chromosome Mapping; Drug Resistance; Floxuridine; Fluorouracil; Genes, Dominant; Genes, Recessive; Mutation; Pyrimidines; Uracil | 1980 |
Mechanism of cytotoxicity of 5-fluorouracil: distinction between the irreversible cytotoxic effect of 5-fluorouridine and the reversible cytotoxic effect of 5-fluoro-2'-deoxyuridine on murine lymphoma L5178Y cells in culture.
Topics: Animals; Cell Division; Cell Line; Floxuridine; Fluorouracil; Leukemia, Experimental; Mice; Uridine | 1980 |
Biochemical and genetic basis of the response to 5-fluorouracil in Drosophila melanogaster.
Topics: Animals; Chromosome Mapping; Cross Reactions; Drosophila melanogaster; Drug Resistance; Floxuridine; Fluorouracil; Genes; Mutation; Thymidylate Synthase | 1980 |
Regulation of RNA- and DNA-directed actions of 5-fluoropyrimidines in mouse T-lymphoma (S-49) cells.
Topics: Animals; Cell Cycle; DNA, Neoplasm; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Leukemia, Experimental; Lymphoma; Mice; Pyrimidine Nucleotides; Pyrimidines; RNA, Neoplasm; Thymidine | 1980 |
Comparative studies on the immunosuppressive effect among 5'-deoxy-5-fluorouridine, ftorafur, and 5-fluorouracil.
Topics: Animals; Antibody Formation; Erythrocytes; Female; Floxuridine; Fluorouracil; Graft Rejection; Hypersensitivity, Delayed; Immunity, Cellular; Immunosuppressive Agents; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation; Tegafur | 1980 |
Tissue distribution of 5'-deoxy-5-fluorouridine and derived 5-fluorouracil in tumor-bearing mice and rats.
Topics: Animals; Carcinoma 256, Walker; Female; Floxuridine; Fluorouracil; Male; Mice; Rats; Sarcoma 180; Tegafur; Tissue Distribution | 1980 |
The difference in mechanism of action of 5-fluorouracil and its nucleosides in L5178y cells.
Topics: Animals; Cell Division; Cell Line; DNA, Neoplasm; Floxuridine; Fluorouracil; Leukemia L5178; Leukemia, Experimental; Mice; Neoplasm Proteins; RNA, Neoplasm; Thymidylate Synthase; Uridine | 1980 |
Isolation and characterization of the murine lymphoma L5178Y cell line highly resistant to 5-fluorouracil.
Topics: Animals; Cell Division; Cell Line; Drug Resistance; Floxuridine; Fluorouracil; Leukemia L5178; Leukemia, Experimental; Mice; Uridine | 1980 |
Determination of 5-fluoro-2'-deoxyuridine[6-3H] as an impurity in 5-fluoro-uracil[6-3H] by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Floxuridine; Fluorouracil; Tritium | 1981 |
Reverse mutation tests in Salmonella typhimurium and chromosomal aberration tests in mammalian cells in culture on fluorinated pyrimidine derivatives.
Topics: Animals; Cell Line; Chromosome Aberrations; Cricetinae; Cricetulus; Floxuridine; Fluorouracil; Mutagenicity Tests; Mutagens; Salmonella typhimurium | 1981 |
Methods for the complete analysis of 5-fluorouracil metabolites in cell extracts.
Topics: Animals; Biotransformation; Cell Extracts; Cells, Cultured; Chromatography, High Pressure Liquid; Floxuridine; Fluorouracil; Leukemia L1210; Mice; Time Factors | 1981 |
Isolation of fluoropyrimidine-resistant murine leukemic cell lines by one-step mutation and selection.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line; Cell Separation; Cytological Techniques; Drug Resistance; Floxuridine; Fluorouracil; Leukemia L1210; Leukemia P388; Leukemia, Experimental; Mice; Mutation; Phenotype; Selection, Genetic; Uridine | 1982 |
An optimal, generalized sampling time of 30 +/- 6 h after double dosing in the mouse peripheral blood micronucleus test.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Carcinogens; Colchicine; Cyclophosphamide; Cytarabine; Floxuridine; Fluorouracil; Kinetics; Methotrexate; Mice; Mice, Inbred Strains; Micronucleus Tests; Mitomycin; Mutagens; Reticulocytes; Sulfuric Acid Esters; Time Factors | 1995 |
Evaluation of plasma 5-fluorouracil nucleoside levels in patients with metastatic breast cancer: relationships with toxicities.
Topics: Adult; Antimetabolites, Antineoplastic; Breast Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Middle Aged; Neoplasm Metastasis; Uridine | 1995 |
Contrasting patterns of DNA fragmentation induced by thymidylate synthase inhibitors, ZD1694 and AG-331.
Topics: Antimetabolites, Antineoplastic; Aphidicolin; Cell Division; DNA Damage; DNA, Neoplasm; Enzyme Inhibitors; Floxuridine; Fluorouracil; Genome; Humans; Indoles; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1995 |
Comparison of 5-fluoro-2'-deoxyuridine and 5-fluorouracil in the treatment of murine colon cancer; effects on thymidylate synthase.
Topics: Animals; Biotransformation; Cell Line; Colonic Neoplasms; Female; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Mice; Mice, Inbred BALB C; Thymidylate Synthase | 1994 |
Increased sensitivity to the prodrug 5'-deoxy-5-fluorouridine and modulation of 5-fluoro-2'-deoxyuridine sensitivity in MCF-7 cells transfected with thymidine phosphorylase.
Topics: Antineoplastic Agents; Biological Availability; Breast; Breast Neoplasms; Cell Communication; Cell Division; Drug Screening Assays, Antitumor; Floxuridine; Fluorouracil; Humans; Prodrugs; Thymidine; Thymidine Phosphorylase; Transfection; Tumor Cells, Cultured | 1995 |
Ionization of bromouracil and fluorouracil stimulates base mispairing frequencies with guanine.
Topics: Base Sequence; Bromodeoxyuridine; Bromouracil; DNA; Floxuridine; Fluorouracil; Guanine; Hydrogen Bonding; Hydrogen-Ion Concentration; Ions; Molecular Sequence Data; Nucleic Acid Heteroduplexes; RNA-Directed DNA Polymerase; Templates, Genetic; Thymine Nucleotides | 1993 |
Sensitivity of human KB cells expressing platelet-derived endothelial cell growth factor to pyrimidine antimetabolites.
Topics: Cell Division; Floxuridine; Fluorouracil; Humans; KB Cells; RNA; Tegafur; Thymidine Kinase; Thymidine Phosphorylase; Transfection | 1993 |
A phase I trial of immediate postoperative intraperitoneal floxuridine and leucovorin plus systemic 5-fluorouracil and levamisole after resection of high risk colon cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Clinical Trials, Phase I as Topic; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; Leucovorin; Levamisole | 1995 |
Flow cytometric analysis of cell-killing actions of 5-fluorouracil in human colorectal cancer cells.
Topics: Cell Cycle; Cell Survival; Colorectal Neoplasms; DNA, Neoplasm; DNA, Ribosomal; Dose-Response Relationship, Drug; Flow Cytometry; Floxuridine; Fluorouracil; Humans; Tumor Cells, Cultured; Tumor Stem Cell Assay; Uridine | 1994 |
Interferon alpha and 5'-deoxy-5-fluorouridine in colon cancer: effects as single agents and in combination on growth of xenograft tumours.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Combined Modality Therapy; Floxuridine; Fluorouracil; Humans; Interferon Type I; Male; Mice; Mice, Nude; Neoplasm Transplantation; Pentosyltransferases; Prodrugs; Pyrimidine Phosphorylases; Recombinant Proteins; Transplantation, Heterologous | 1994 |
Compatibility of morphine, baclofen, floxuridine and fluorouracil in an implantable medication pump.
Topics: Baclofen; Chromatography, High Pressure Liquid; Drug Incompatibility; Drug Stability; Floxuridine; Fluorouracil; Infusion Pumps, Implantable; Morphine; Solutions; Spectrophotometry, Ultraviolet | 1995 |
The effects of 5-fluoropyrimidines on nascent DNA synthesis in Chinese hamster ovary cells monitored by pH-step alkaline and neutral elution.
Topics: Animals; Cell Survival; CHO Cells; Cricetinae; DNA; Floxuridine; Fluorouracil; Hydrogen-Ion Concentration | 1994 |
Characterization of and the influence of calcium channel blockers on the renal excretion of pyrimidine anticancer agents.
Topics: Absorption; Animals; Biological Transport; Blood Proteins; Calcium Channels; Carrier Proteins; Chromatography, High Pressure Liquid; Diltiazem; Floxuridine; Fluorouracil; Inulin; Kidney; Male; Membrane Proteins; Mice; Monosaccharide Transport Proteins; Nucleoside Transport Proteins; Verapamil | 1994 |
Regional chemotherapy for colorectal liver metastases: thirty years without patient benefit.
Topics: Colorectal Neoplasms; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Incidence; Infusions, Intra-Arterial; Liver Neoplasms; Randomized Controlled Trials as Topic; Time Factors; Treatment Failure | 1994 |
[The evolution of the liver metastases from colorectal carcinoma treated with hepatic intra-arterial chemotherapy. The echographic and CT aspects].
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Colorectal Neoplasms; Floxuridine; Fluorouracil; Follow-Up Studies; Humans; Infusions, Intra-Arterial; Italy; Leucovorin; Liver; Liver Neoplasms; Remission Induction; Retrospective Studies; Tomography, X-Ray Computed; Ultrasonography | 1994 |
Differential effects of acyclothymidine, a potent pyrimidine nucleoside phosphorylase inhibitor, on the pharmacokinetics of doxifluridine in rabbits via oral administration.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Drug Interactions; Floxuridine; Fluorouracil; Male; Pentosyltransferases; Pyrimidine Phosphorylases; Rabbits; Uracil | 1993 |
[A comparative study on the serum and tissue 5-FU concentrations in patients with hepatocellular carcinoma after preoperative oral administration of UFT and 5'-DFUR].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Chemotherapy, Adjuvant; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Liver; Liver Neoplasms; Male; Middle Aged; Tegafur; Uracil | 1994 |
New mechanism of action of the cancer chemotherapeutic agent 5-fluorouracil in human cells.
Topics: Binding, Competitive; Cell Count; Cells, Cultured; DNA; DNA Glycosylases; Fibroblasts; Floxuridine; Fluorouracil; Humans; Kinetics; N-Glycosyl Hydrolases; Uracil; Uracil-DNA Glycosidase | 1994 |
The significance of preoperative chemotherapy for early gastric carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Staging; Preoperative Care; Prognosis; Stomach Neoplasms; Tegafur; Uracil | 1993 |
[Study on the relationship between concentrations of 5-FU and PyNPase activity in tumor tissue during oral 5'-DFUR treatment in patients with advanced colorectal cancer].
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Antineoplastic Agents; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Pentosyltransferases; Pyrimidine Phosphorylases | 1994 |
Differences in activities and substrate specificity of human and murine pyrimidine nucleoside phosphorylases: implications for chemotherapy with 5-fluoropyrimidines.
Topics: Animals; Floxuridine; Fluorouracil; Humans; Liver; Mice; Placenta; Species Specificity; Substrate Specificity; Thymidine Phosphorylase; Uridine; Uridine Phosphorylase | 1993 |
Cytokines induce thymidine phosphorylase expression in tumor cells and make them more susceptible to 5'-deoxy-5-fluorouridine.
Topics: Antineoplastic Agents; Blotting, Northern; Cell Division; Colonic Neoplasms; Cytokines; Depression, Chemical; Drug Synergism; Enzyme Induction; Floxuridine; Fluorouracil; Humans; Interferon-gamma; Interleukin-1; RNA, Messenger; Stomach Neoplasms; Thymidine Phosphorylase; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1993 |
Cytotoxic mechanisms of 5-fluoropyrimidines. Relationships with poly(ADP-ribose) polymerase activity, DNA strand breakage and incorporation into nucleic acids.
Topics: Animals; Benzamides; CHO Cells; Colony-Forming Units Assay; Cricetinae; Cricetulus; DNA Damage; Floxuridine; Fluorouracil; NAD; Nucleic Acids; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases | 1993 |
Functional effects of a naturally occurring amino acid substitution in human thymidylate synthase.
Topics: Base Sequence; Binding Sites; Floxuridine; Fluorouracil; Histidine; Humans; Hydrogen-Ion Concentration; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Temperature; Tetrahydrofolates; Thymidylate Synthase; Tumor Cells, Cultured; Tyrosine | 1993 |
Solid-phase extraction of fluoropyrimidine derivatives on a copper-modified strong cation exchanger: determination of doxifluridine, 5-fluorouracil and its main metabolites in serum by high-performance liquid chromatography with ultraviolet detection.
Topics: Adsorption; Antineoplastic Agents; Cations; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Copper; Floxuridine; Fluorouracil; Humans; Isomerism; Spectrophotometry, Ultraviolet | 1993 |
Circadian rhythm of orotate phosphoribosyltransferase, pyrimidine nucleoside phosphorylases and dihydrouracil dehydrogenase in mouse liver. Possible relevance to chemotherapy with 5-fluoropyrimidines.
Topics: Animals; Circadian Rhythm; Dihydrouracil Dehydrogenase (NAD+); Female; Floxuridine; Fluorouracil; Liver; Mathematics; Mice; Orotate Phosphoribosyltransferase; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Purine-Nucleoside Phosphorylase | 1993 |
Isolation and characterization of a human ileocecal carcinoma cell line (HCT-8) subclone resistant to fluorodeoxyuridine.
Topics: Antimetabolites, Antineoplastic; Cell Division; Colonic Neoplasms; Drug Resistance; Floxuridine; Fluorouracil; Humans; Methotrexate; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidine Kinase; Thymidine Phosphorylase; Thymidylate Synthase; Tumor Cells, Cultured | 1993 |
Cytokines induce uridine phosphorylase in mouse colon 26 carcinoma cells and make the cells more susceptible to 5'-deoxy-5-fluorouridine.
Topics: Animals; Antineoplastic Agents; Cell Division; Colonic Neoplasms; Cytokines; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Induction; Fibroblast Growth Factor 2; Floxuridine; Fluorouracil; Interferon-gamma; Interleukin-1; Mice; RNA, Neoplasm; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Uridine; Uridine Phosphorylase | 1993 |
Regional hepatic arterial chemotherapy for colorectal cancer metastatic to the liver: the controversy continues.
Topics: Colorectal Neoplasms; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusion Pumps; Infusions, Intra-Arterial; Liver Neoplasms; Randomized Controlled Trials as Topic | 1993 |
Characteristics of cancer cell death after exposure to cytotoxic drugs in vitro.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Death; Dexamethasone; DNA, Neoplasm; Flow Cytometry; Floxuridine; Fluorouracil; Humans; Leukemia-Lymphoma, Adult T-Cell; Methotrexate; Tumor Cells, Cultured; Vincristine | 1996 |
Role of fluoropyrimidine Schedule and (6R,S)leucovorin dose in a preclinical animal model of colorectal carcinoma.
Topics: Animals; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Leucovorin; Rats; Rats, Inbred F344; Time Factors | 1996 |
Re: Reappraisal of hepatic arterial infusion in the treatment of nonresectable liver metastases from colorectal cancer.
Topics: Antimetabolites, Antineoplastic; Colorectal Neoplasms; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Quality of Life; Survival Analysis; Treatment Outcome | 1996 |
The influence of BIBW22BS, a dipyridamole derivative, on the antiproliferative effects of 5-fluorouracil, methotrexate and gemcitabine in vitro and in human tumour xenografts.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Deoxycytidine; Dipyridamole; Doxorubicin; Drug Resistance; Female; Floxuridine; Fluorouracil; Gemcitabine; Humans; Methotrexate; Mice; Mice, Nude; Morpholines; Neoplasms; Neoplasms, Experimental; Protein Binding; Transplantation, Heterologous; Triamterene; Tumor Cells, Cultured; Vincristine | 1995 |
Intraarterial hepatic chemotherapy with fluorouracil, fluorodeoxyuridine, mitomycin C, cisplatin or methotrexate as single-agent anticancer drugs for a transplanted experimental liver tumor in rats.
Topics: Angiography; Animals; Antineoplastic Agents; Cisplatin; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Injections, Intra-Arterial; Liver Neoplasms, Experimental; Male; Methotrexate; Mitomycin; Neoplasm Transplantation; Prospective Studies; Rats; Rats, Sprague-Dawley | 1996 |
Modulation of the pharmacokinetics of 5'-deoxy-5-fluorouridine and 5-fluorouracil in rats by oral co-administration of acyclothymidine.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Drug Interactions; Enzyme Inhibitors; Floxuridine; Fluorouracil; Intestines; Liver; Male; Pentosyltransferases; Pyrimidine Phosphorylases; Rats; Uracil | 1996 |
Isolated lung perfusion with FUDR in the rat: pharmacokinetics and survival.
Topics: Animals; Antimetabolites, Antineoplastic; Chemotherapy, Cancer, Regional Perfusion; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Floxuridine; Fluorouracil; Infusions, Intravenous; Lung; Lung Neoplasms; Male; Rats; Rats, Inbred F344 | 1996 |
[Intra-arterial infusion chemotherapy for liver metastases from breast cancer].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Administration Schedule; Epirubicin; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Liver Neoplasms; Medroxyprogesterone; Middle Aged | 1996 |
Alternating floxuridine and 5-fluorouracil hepatic arterial chemotherapy for colorectal liver metastases minimizes biliary toxicity.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biliary Tract Diseases; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Retrospective Studies | 1996 |
Preparation of anti-human thymidine phosphorylase monoclonal antibodies useful for detecting the enzyme levels in tumor tissues.
Topics: Animals; Antibodies, Monoclonal; Enzyme-Linked Immunosorbent Assay; Floxuridine; Fluorouracil; Humans; Male; Mice; Mice, Inbred BALB C; Neoplasms; Thymidine Phosphorylase | 1996 |
Mechanisms of acquired resistance to modulation of 5-fluorouracil by leucovorin in HCT-8 human ileocecal carcinoma cells.
Topics: Antimetabolites, Antineoplastic; Drug Resistance; Floxuridine; Fluorouracil; Humans; Leucovorin; Thymidylate Synthase; Tumor Cells, Cultured | 1997 |
[Pyrimidine nucleoside phosphorylase activity, 5-fluorouracil concentration and thymidylate synthase inhibition rate in colorectal cancer after oral administration of 5'-doxifluridine].
Topics: Adenocarcinoma; Administration, Oral; Aged; Antineoplastic Agents; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Pentosyltransferases; Pyrimidine Phosphorylases; Thymidylate Synthase | 1997 |
Irreversible cytotoxic effect of a novel lowly immunosuppressive antitumor fluorouridine derivative, UK-21.
Topics: Antimetabolites, Antineoplastic; Cell Cycle; Cell Survival; Flow Cytometry; Floxuridine; Fluorouracil; Glycine; Humans; Immunosuppressive Agents; KB Cells; Neoplastic Stem Cells; Thymidine; Uridine | 1997 |
Moment analysis of intestinal first-pass metabolism by portal-systemic concentration difference in single conscious rat using 5'-deoxy-5-fluorouridine and 5-fluorouracil as model drug system.
Topics: Animals; Biological Availability; Floxuridine; Fluorouracil; Intestinal Mucosa; Liver; Male; Rats; Rats, Wistar | 1997 |
Positive correlation between the efficacy of capecitabine and doxifluridine and the ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase activities in tumors in human cancer xenografts.
Topics: Animals; Antineoplastic Agents; Capecitabine; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Floxuridine; Fluorouracil; Humans; Mice; Neoplasm Transplantation; Oxidoreductases; Thymidine Phosphorylase | 1998 |
Mechanisms for 5-fluorouracil resistance in human colon cancer DLD-1 cells.
Topics: Antimetabolites, Antineoplastic; Cell Count; Colorectal Neoplasms; Drug Resistance, Neoplasm; Floxuridine; Fluorouracil; Humans; Intracellular Fluid; Phosphoribosyl Pyrophosphate; RNA, Neoplasm; Thymidylate Synthase; Tumor Cells, Cultured; Uridine | 1998 |
Effect of coadministered uridine on intestinal first-pass metabolism of 5'-deoxy-5-fluorouridine in conscious rats--an evaluation by method of portal-systemic concentration difference.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Arteries; Drug Interactions; Floxuridine; Fluorouracil; Intestinal Absorption; Intestinal Mucosa; Intestines; Male; Portal System; Portal Vein; Rats; Rats, Wistar; Uridine | 1998 |
Antitumor activities of a novel fluoropyrimidine, N4-pentyloxycarbonyl-5'-deoxy-5-fluorocytidine (capecitabine).
Topics: Analysis of Variance; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Capecitabine; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Male; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Pyrimidines; Subrenal Capsule Assay | 1998 |
[The correlation between thymidine phosphorylase activity of renal cancer cells and the chemosensitivity to 5-FU and 5'-DFUR].
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Carcinoma, Renal Cell; Drug Screening Assays, Antitumor; Floxuridine; Fluorouracil; Humans; Kidney Neoplasms; Thymidine Phosphorylase; Tumor Cells, Cultured | 1998 |
[In vitro study on intrathecal application of 5-fluoro-2'-deoxyuridine (FdUrd) for meningeal dissemination of malignant tumor].
Topics: Animals; Antimetabolites, Antineoplastic; Brain Neoplasms; Carcinoma 256, Walker; Floxuridine; Fluorouracil; Glioma; Humans; Injections, Spinal; Mice; Mice, Inbred C57BL; Rats; Thymidine Kinase; Thymidine Phosphorylase; Tumor Cells, Cultured | 1998 |
A cystic biliary tumour responding to regional fluorinated pyrimidine infusion.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biliary Tract Neoplasms; Cysts; Floxuridine; Fluorouracil; Hamartoma; Humans; Infusions, Intra-Arterial; Male; Pyrimidines; Treatment Outcome | 1998 |
Thymidine phosphorylase activity in human bladder cancer: difference between superficial and invasive cancer.
Topics: Epithelial Cells; Floxuridine; Fluorouracil; Humans; Kinetics; Neoplasm Invasiveness; Neoplasm Staging; Thymidine Phosphorylase; Urinary Bladder; Urinary Bladder Neoplasms | 1997 |
Therapeutic efficacy of fluoropyrimidines depends on the duration of thymidylate synthase inhibition in the murine colon 26-B carcinoma tumor model.
Topics: Animals; Antimetabolites, Antineoplastic; Colonic Neoplasms; Female; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Mice; Mice, Inbred BALB C; RNA; Thymidylate Synthase; Time Factors | 1996 |
Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue.
Topics: Animals; Capecitabine; Carboxylic Ester Hydrolases; Cytidine Deaminase; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Liver; Male; Mice; Neoplasms; Thymidine Phosphorylase | 1998 |
[A case of giant advanced breast cancer responding remarkably to chemo-endocrine therapy chiefly with doxifluridine].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Carcinoma, Ductal, Breast; Cyclophosphamide; Drug Administration Schedule; Epirubicin; Female; Floxuridine; Fluorouracil; Humans; Pleural Effusion, Malignant; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen | 1998 |
Enhancement of 5-fluorouracil cytotoxicity by human thymidine-phosphorylase expression in cancer cells: in vitro and in vivo study.
Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma; Colonic Neoplasms; Drug Synergism; Floxuridine; Fluorouracil; Humans; Mice; Mice, Inbred BALB C; Neoplasm Proteins; Thymidine Phosphorylase; Transfection | 1999 |
Suppression of replication of multidrug-resistant HIV type 1 variants by combinations of thymidylate synthase inhibitors with zidovudine or stavudine.
Topics: Anti-HIV Agents; Antimetabolites; Drug Interactions; Drug Resistance, Microbial; Drug Resistance, Multiple; Floxuridine; Fluorouracil; HIV-1; Humans; Mutation; Reverse Transcriptase Inhibitors; Stavudine; Thymidylate Synthase; Thymine Nucleotides; Virus Replication; Zidovudine | 1999 |
[Effective chemo-endocrine combination therapy for obstructive-jaundice caused by multiple liver metastasis of recurrent breast cancer--a case report].
Topics: Aged; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cholestasis; Cyclophosphamide; Doxorubicin; Drainage; Female; Floxuridine; Fluorouracil; Humans; Liver Neoplasms; Lung Neoplasms; Mastectomy, Radical; Medroxyprogesterone Acetate; Tamoxifen; Tegafur; Toremifene; Uracil | 1999 |
Inhibition of cyclin D1 expression in human pancreatic cancer cells is associated with increased chemosensitivity and decreased expression of multiple chemoresistance genes.
Topics: Adenocarcinoma; Cyclin D1; Drug Resistance, Neoplasm; Enzyme Induction; Floxuridine; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Mitoxantrone; Neoplasm Proteins; Oligonucleotides, Antisense; Pancreatic Neoplasms; RNA, Messenger; RNA, Neoplasm; Thymidine Phosphorylase; Thymidylate Synthase; Transfection; Tumor Cells, Cultured | 1999 |
Antitumor activity of ZD1694 (tomudex) against human head and neck cancer in nude mouse models: role of dosing schedule and plasma thymidine.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Head and Neck Neoplasms; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Quinazolines; Thiophenes; Thymidine; Transplantation, Heterologous; Tumor Cells, Cultured | 1999 |
[A case of breast cancer with liver metastases responding remarkably to combination therapy of mitoxantrone (MIT), doxifluridine (5'-DFUR) and medroxyprogesterone acetate (MPA)].
Topics: Administration, Oral; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Drug Resistance, Neoplasm; Epirubicin; Female; Floxuridine; Fluorouracil; Humans; Liver Neoplasms; Medroxyprogesterone Acetate; Middle Aged; Mitoxantrone; Tamoxifen | 1999 |
Induction of thymidine phosphorylase expression and enhancement of efficacy of capecitabine or 5'-deoxy-5-fluorouridine by cyclophosphamide in mammary tumor models.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Capecitabine; Cyclophosphamide; Deoxycytidine; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Humans; Kinetics; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasm Transplantation; Thymidine Phosphorylase; Time Factors; Up-Regulation | 1999 |
Increased cytotoxicity and bystander effect of 5-fluorouracil and 5-deoxy-5-fluorouridine in human colorectal cancer cells transfected with thymidine phosphorylase.
Topics: Adenocarcinoma; Antineoplastic Agents; Cell Survival; Cloning, Molecular; Colorectal Neoplasms; DNA, Complementary; Floxuridine; Fluorouracil; Humans; Recombinant Proteins; Thymidine Phosphorylase; Transfection; Tumor Cells, Cultured | 1999 |
UFT and its metabolites inhibit the angiogenesis induced by murine renal cell carcinoma, as determined by a dorsal air sac assay in mice.
Topics: 4-Butyrolactone; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cell Division; Diffusion Chambers, Culture; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Hydroxybutyrates; Kidney Neoplasms; Male; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neovascularization, Pathologic; Tegafur; Tumor Cells, Cultured; Uracil | 1999 |
Antisense down-regulation of thymidylate synthase to suppress growth and enhance cytotoxicity of 5-FUdR, 5-FU and Tomudex in HeLa cells.
Topics: Antimetabolites, Antineoplastic; Cell Count; Down-Regulation; Female; Floxuridine; Fluorouracil; HeLa Cells; Humans; Oligonucleotides, Antisense; Quinazolines; RNA, Messenger; Thiophenes; Thymidylate Synthase; Transfection | 1999 |
[Successful endocrine chemotherapy in patients with multiple bone metastases of breast cancer--a case report].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Combined Modality Therapy; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Medroxyprogesterone; Middle Aged; Tamoxifen | 1999 |
[Long-term complete response in a case of unresectable rectal cancer following chemoradiation].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Radiotherapy Dosage; Rectal Neoplasms; Remission Induction; Tegafur; Uracil | 2000 |
[A case of diffusely infiltrating carcinoma of the sigmoid colon associated with lymphangitis carcinomatosa effectively treated with sequential MTX.5-FU and 5'-DFUR].
Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Floxuridine; Fluorouracil; Humans; Lymphangitis; Male; Methotrexate; Sigmoid Neoplasms | 2000 |
Theoretical considerations and in vitro concentration response studies with two human colorectal carcinoma cell lines. The rational experimental base for clinical studies in regional chemotherapy.
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Carcinoma; Cisplatin; Colorectal Neoplasms; Doxorubicin; Epirubicin; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Melphalan; Mitomycin; Mitoxantrone; Tumor Cells, Cultured | 2000 |
[A case of recurrent breast cancer with carcinoma erysipeloides responding to sequential therapy with docetaxel (TXT) and doxifluridine (5'-DFUR) accompanied by leucovorin (LV)].
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma; Cyclophosphamide; Docetaxel; Doxorubicin; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Injections, Intra-Arterial; Leucovorin; Mastectomy; Middle Aged; Neoplasm Recurrence, Local; Paclitaxel; Skin Neoplasms; Taxoids | 2000 |
Hepatic arterial infusion of chemotherapy for metastatic colorectal cancer.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Data Interpretation, Statistical; Disease-Free Survival; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Survival Rate | 2000 |
Different mechanisms of acquired resistance to fluorinated pyrimidines in human colorectal cancer cells.
Topics: Antimetabolites, Antineoplastic; Cell Division; Colorectal Neoplasms; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Floxuridine; Fluorouracil; Humans; Neoplasm Proteins; Thymidylate Synthase; Trifluridine; Tumor Cells, Cultured | 2000 |
[Comparison of pharmacokinetics of 5-FU and alpha-fluoro-beta-alanine, a metabolite of 5-FU, in plasma after administration of UFT, tegafur, 5-FU or doxifluridine to rats].
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; beta-Alanine; Floxuridine; Fluorouracil; Male; Rats; Rats, Sprague-Dawley; Tegafur; Uracil | 2000 |
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Capecitabine; Carbamates; Carboxylic Ester Hydrolases; Deoxycytidine; Drug Delivery Systems; Floxuridine; Fluorouracil; Humans; Intestines; Kinetics; Liver; Macaca fascicularis; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Prodrugs; Structure-Activity Relationship; Substrate Specificity; Transplantation, Heterologous | 2000 |
Disposition and availability of 5-fluorouracil prodrug 5'-deoxy-5-fluorouridine after oral administration in rats.
Topics: Absorption; Administration, Oral; Animals; Antimetabolites, Antineoplastic; Biological Availability; Female; Floxuridine; Fluorouracil; Prodrugs; Rats; Rats, Inbred F344 | 1987 |
Intratumoral pyrimidine nucleoside phosphorylase (PyNPase) activity predicts a selective effect of adjuvant 5'-deoxy-5-fluorouridine (5'DFUR) on breast cancer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Breast Neoplasms; Carcinoma, Ductal, Breast; Chemotherapy, Adjuvant; Chromatography, High Pressure Liquid; Disease-Free Survival; Female; Floxuridine; Fluorouracil; Follow-Up Studies; Humans; Lymphatic Metastasis; Mastectomy, Radical; Menopause; Middle Aged; Mitomycin; Neoplasm Proteins; Pentosyltransferases; Prodrugs; Pyrimidine Phosphorylases; Tamoxifen; Thymidine Phosphorylase; Treatment Outcome | 2000 |
Pharmacokinetics of gemcitabine and 2',2'-difluorodeoxyuridine in a patient with ascites.
Topics: Abdominal Pain; Adenocarcinoma; Antimetabolites, Antineoplastic; Ascites; Catheters, Indwelling; Chromatography, High Pressure Liquid; Deoxycytidine; Female; Floxuridine; Fluorouracil; Gemcitabine; Humans; Middle Aged; Pancreatic Neoplasms; Urinary Tract Infections | 2000 |
[A case of locally advanced rectal carcinoma with liver metastasis treated with a combination of CRT, HAI, and systemic chemotherapy].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Combined Modality Therapy; Drug Administration Schedule; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Radiotherapy Dosage; Rectal Neoplasms; Suppositories | 2000 |
Surrogate endpoints for new colorectal cancer drugs.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Leucovorin; Methotrexate; Randomized Controlled Trials as Topic; Survival Analysis | 2000 |
[A case of advanced breast cancer that responded remarkably to chemotherapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Medroxyprogesterone Acetate; Middle Aged | 2000 |
Reduced cellular transport and activation of fluoropyrimidine nucleosides and resistance in human lymphocytic cell lines selected for arabinosylcytosine resistance.
Topics: Antimetabolites, Antineoplastic; Biological Transport; Cell Line; Cytarabine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Floxuridine; Fluorouracil; HL-60 Cells; Humans | 2001 |
[A case of breast cancer with multiple organ metastases responding remarkably to combination therapy of CAF (cyclophosphamide, adriamycin and 5-FU), 5'-DFUR and MPA (medroxyprogesterone acetate)].
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Mastectomy; Medroxyprogesterone Acetate; Middle Aged; Remission Induction | 2000 |
[Advanced breast cancer with multiple bone metastases successfully treated with combined chemoendocrine-therapy of CEF (cyclophosphamide, epirubicin, 5-fluorouracil) and 5'-DFUR (5'-deoxy-5-fluorouridine) + MPA (medroxyprogesterone acetate)--a case report
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Cyclophosphamide; Drug Therapy, Combination; Epirubicin; Female; Floxuridine; Fluorouracil; Humans; Medroxyprogesterone; Middle Aged; Progesterone Congeners; Treatment Outcome | 2001 |
Enhancement of sensitivity to capecitabine in human renal carcinoma cells transfected with thymidine phosphorylase cDNA.
Topics: Animals; Antimetabolites, Antineoplastic; Capecitabine; Carcinoma, Renal Cell; Cell Survival; Deoxycytidine; Disease Models, Animal; DNA, Complementary; Drug Screening Assays, Antitumor; Floxuridine; Fluorouracil; Kidney Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Thymidine Phosphorylase; Transfection; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2001 |
Thymidine kinase, thymidylate synthase, and dihydropyrimidine dehydrogenase profiles of cell lines of the National Cancer Institute's Anticancer Drug Screen.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Cell Line; Databases, Factual; Dihydrouracil Dehydrogenase (NADP); DNA; Drug Screening Assays, Antitumor; Floxuridine; Fluorouracil; Humans; Mutation; National Institutes of Health (U.S.); Oxidoreductases; RNA, Messenger; Thymidine; Thymidine Kinase; Thymidylate Synthase; Tumor Cells, Cultured; Tumor Suppressor Protein p53; United States | 2001 |
Schedule dependency of antitumor activity in combination therapy with capecitabine/5'-deoxy-5-fluorouridine and docetaxel in breast cancer models.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Deoxycytidine; Disease Models, Animal; Docetaxel; Drug Administration Schedule; Drug Combinations; Female; Floxuridine; Fluorouracil; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Paclitaxel; Taxoids; Thymidine Phosphorylase; Tumor Cells, Cultured; Up-Regulation; Xenograft Model Antitumor Assays | 2001 |
Role of the human concentrative nucleoside transporter (hCNT1) in the cytotoxic action of 5[Prime]-deoxy-5-fluorouridine, an active intermediate metabolite of capecitabine, a novel oral anticancer drug.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Capecitabine; Carrier Proteins; Cell Survival; CHO Cells; Cloning, Molecular; Cricetinae; Deoxycytidine; DNA, Complementary; Drug Screening Assays, Antitumor; Fetus; Floxuridine; Fluorouracil; Humans; Liver; Membrane Transport Proteins; Oocytes; Prodrugs; Transfection; Xenopus laevis | 2001 |
Beyond hydroxyurea.
Topics: Animals; Antiviral Agents; Benzamidines; Dipyridamole; Disease Models, Animal; Floxuridine; Fluorouracil; Humans; Hydroxamic Acids; Hydroxyurea; Mice; Murine Acquired Immunodeficiency Syndrome; Ribonucleotide Reductases | 1995 |
Sequential intrahepatic and systemic fluoropyrimidine-based chemotherapy for metastatic colorectal cancer confined to the liver. A phase II study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease-Free Survival; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Male; Middle Aged; Survival Rate; Treatment Outcome | 2001 |
Role of the hMLH1 DNA mismatch repair protein in fluoropyrimidine-mediated cell death and cell cycle responses.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antimetabolites, Antineoplastic; Carrier Proteins; Cell Death; Colonic Neoplasms; Cyclin B; Cyclin B1; DNA Damage; DNA Repair; Drug Resistance, Neoplasm; Fibroblasts; Floxuridine; Fluorouracil; G2 Phase; GADD45 Proteins; Humans; Intracellular Signaling Peptides and Proteins; Mice; Mitosis; MutL Protein Homolog 1; Neoplasm Proteins; Nuclear Proteins; Proteins; Staining and Labeling; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2001 |
Impact of thymidine phosphorylase surexpression on fluoropyrimidine activity and on tumour angiogenesis.
Topics: Animals; Antimetabolites, Antineoplastic; Colonic Neoplasms; Drug Resistance, Neoplasm; Floxuridine; Fluorouracil; Formazans; Neoplasm Transplantation; Neovascularization, Pathologic; Pentosyltransferases; Pyrimidine Phosphorylases; Rats; Tetrazolium Salts; Thymidine Phosphorylase; Transfection; Tumor Cells, Cultured | 2001 |
Thymidine phosphorylase expression is useful in selecting adjuvant chemotherapy for stage III gastric cancer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Floxuridine; Fluorouracil; Humans; Immunoenzyme Techniques; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Staging; Stomach Neoplasms; Survival Rate; Thymidine Phosphorylase; Treatment Outcome | 2001 |
Docetaxel alone or orally combined with 5-fluorouracil and its derivatives: effects on mouse mammary tumor cell line MM2 in vitro and in vivo.
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Docetaxel; Drug Synergism; Female; Floxuridine; Fluorouracil; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Paclitaxel; Prodrugs; Taxoids; Thymidine Phosphorylase; Tumor Cells, Cultured; Up-Regulation | 2001 |
[Effect of peroral doxifluridine plus hepatic arterial infusion for synchronous liver metastasis of colorectal cancer--correlation with the expression of thymidine phosphorylase and dihydropyrimidine dehydrogenase in primary colorectal cancer lesions].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Oxidoreductases; Survival Rate; Thymidine Phosphorylase | 2001 |
Plasma, intestine and tumor levels of 5-fluorouracil in mice bearing L1210 ascites tumor following oral administration of 5-fluorouracil, UFT (mixed compound of tegafur and uracil), carmofur and 5'-deoxy-5-fluorouridine.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Drug Combinations; Floxuridine; Fluorouracil; Intestinal Mucosa; Leukemia L1210; Male; Mice; Tegafur; Uracil | 2001 |
Immunohistochemical variation of human equilibrative nucleoside transporter 1 protein in primary breast cancers.
Topics: Affinity Labels; Animals; Antibodies, Monoclonal; Antibody Formation; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Deoxycytidine; Drug Resistance, Neoplasm; Equilibrative Nucleoside Transporter 1; Female; Floxuridine; Fluorouracil; Humans; Immunoenzyme Techniques; Membrane Transport Proteins; Mice; Neoplasm Invasiveness; Neoplasm Proteins; Neoplasm Staging; Thioinosine | 2002 |
gamma-Hydroxybutyric acid and 5-fluorouracil, metabolites of UFT, inhibit the angiogenesis induced by vascular endothelial growth factor.
Topics: Angiogenesis Inhibitors; Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Carcinoma; Carcinoma, Renal Cell; Chemotaxis; Colonic Neoplasms; DNA Replication; Drug Combinations; Endothelial Growth Factors; Endothelium, Vascular; Female; Fibroblast Growth Factor 2; Floxuridine; Fluorouracil; Humans; Intercellular Signaling Peptides and Proteins; Kidney Neoplasms; Lung Neoplasms; Lymphokines; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Neoplasm Proteins; Neovascularization, Pathologic; Prodrugs; Prostheses and Implants; Recombinant Proteins; Sodium Oxybate; Stomach Neoplasms; Tegafur; Tumor Cells, Cultured; Uracil; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Xenograft Model Antitumor Assays | 2001 |
Overexpression of pyrimidine nucleoside phosphorylase enhances the sensitivity to 5'-deoxy-5-fluorouridine in tumour cells in vitro and in vivo.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Cell Survival; Colonic Neoplasms; Combined Modality Therapy; DNA, Complementary; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Floxuridine; Fluorouracil; Genetic Therapy; Humans; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Pentosyltransferases; Prodrugs; Pyrimidine Phosphorylases; Transfection; Tumor Cells, Cultured | 2002 |
Echogenicity of liver metastases from colorectal carcinoma is an independent prognostic factor in patients treated with regional chemotherapy.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Liver Neoplasms; Male; Middle Aged; Monitoring, Intraoperative; Predictive Value of Tests; Prospective Studies; Retrospective Studies; Survival Analysis; Treatment Outcome; Ultrasonography | 2002 |
Thymidine phosphorylase activity in renal cell carcinoma: relationship between histological parameters and chemosensitivity to fluorouracil-related drugs.
Topics: Antimetabolites, Antineoplastic; Carcinoma, Renal Cell; Floxuridine; Fluorouracil; Humans; Kidney; Kidney Neoplasms; Reference Values; Thymidine Phosphorylase | 2002 |
[A case of recurrent gastric cancer that responded dramatically to docetaxel and 5'-DFUR combination chemotherapy].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Docetaxel; Drug Administration Schedule; Floxuridine; Fluorouracil; Gastrectomy; Humans; Liver Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Invasiveness; Paclitaxel; Pancreatic Neoplasms; Stomach Neoplasms; Taxoids; Treatment Outcome | 2002 |
[A case of colon metastasis to the lung treated successfully with combined chemotherapy of CPT-11 and 5'-DFUR].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Drug Administration Schedule; Drug Combinations; Floxuridine; Fluorouracil; Humans; Irinotecan; Lung Neoplasms; Male; Middle Aged; Rectal Neoplasms; Tegafur; Uracil | 2002 |
Comparison of 5-fluorouracil and 5-fluoro-2'-deoxyuridine as an effector in radiation-activated prodrugs.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Colony-Forming Units Assay; Female; Floxuridine; Fluorouracil; Humans; In Vitro Techniques; Injections, Intraperitoneal; Mice; Mice, Inbred C3H; Pancreatic Neoplasms; Prodrugs; Tumor Cells, Cultured | 2002 |
Cytosolic and microsomal activation of doxifluridine and tegafur to produce 5-fluorouracil in human liver.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Cytosol; Floxuridine; Fluorouracil; Humans; In Vitro Techniques; Microsomes, Liver; Mixed Function Oxygenases; Steroid Hydroxylases; Tegafur; Thymidine Phosphorylase | 2002 |
Detection of thymidylate synthase modulators by a novel screening assay.
Topics: Antimetabolites, Antineoplastic; DNA-Binding Proteins; Early Growth Response Protein 1; Enzyme Induction; Floxuridine; Fluorouracil; Humans; Immediate-Early Proteins; Luciferases; Promoter Regions, Genetic; Thymidylate Synthase; Transcription Factors; Transfection; Tumor Cells, Cultured; Up-Regulation | 2003 |
Penetration of capecitabine and its metabolites into malignant and healthy tissue of patients with advanced breast cancer.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Deoxycytidine; Electrophoresis, Capillary; Extracellular Space; Floxuridine; Fluorouracil; Humans; Prodrugs; Skin Neoplasms; Tissue Distribution | 2002 |
Technical complications of continuous intra-arterial chemotherapy with 5-fluorodeoxyuridine and 5-fluorouracil for colorectal liver metastases.
Topics: Antimetabolites, Antineoplastic; Catheterization; Colorectal Neoplasms; Disease-Free Survival; Female; Floxuridine; Fluorouracil; Humans; Infusion Pumps; Infusions, Intra-Arterial; Liver Neoplasms; Male; Postoperative Care; Retrospective Studies | 2003 |
Hepatic artery infusion for liver metastases from colorectal cancer.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Colorectal Neoplasms; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Irinotecan; Liver Neoplasms; Survival Analysis; Treatment Outcome | 2003 |
Depression of phenytoin metabolic capacity by 5-fluorouracil and doxifluridine in rats.
Topics: Animals; Anticonvulsants; Antimetabolites, Antineoplastic; Cytochrome P-450 Enzyme System; Down-Regulation; Drug Interactions; Floxuridine; Fluorouracil; Male; Microsomes, Liver; Phenytoin; Rats; Rats, Sprague-Dawley | 2003 |
Effects of chlorin-mediated photodynamic therapy combined with fluoropyrimidines in vitro and in a patient.
Topics: Apoptosis; Breast Neoplasms; Carcinoma, Basal Cell; Floxuridine; Fluorouracil; Humans; Male; Mesoporphyrins; Photochemotherapy; Photosensitizing Agents; Porphyrins; Prostatic Neoplasms; Skin Neoplasms; Tumor Cells, Cultured | 2003 |
Preparation and characterization of chitosan microspheres containing doxifluridine.
Topics: Animals; Antimetabolites, Antineoplastic; Chemistry, Pharmaceutical; Chitin; Chitosan; Drug Implants; Floxuridine; Fluorouracil; Male; Mice; Microspheres; Rats; Rats, Wistar; Tegafur | 2003 |
MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine.
Topics: Adenine; Adenosine Triphosphate; Animals; Antineoplastic Agents; Antiviral Agents; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Cell Membrane; Colforsin; Coloring Agents; Cyclic AMP; Cyclic GMP; DNA, Complementary; Dose-Response Relationship, Drug; Drug Resistance; Floxuridine; Fluorouracil; Genetic Vectors; Growth Inhibitors; Immunoblotting; Inhibitory Concentration 50; Insecta; Models, Biological; Nitrosamines; Nucleotides; Organophosphonates; Swine; Tetrazolium Salts; Thiazoles; Time Factors; Transfection; Zalcitabine | 2003 |
Hepatic artery chemotherapy and colorectal liver metastases.
Topics: Antineoplastic Agents; Colorectal Neoplasms; Controlled Clinical Trials as Topic; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusion Pumps, Implantable; Injections, Intra-Arterial; Liver Neoplasms | 2003 |
Hepatic artery chemotherapy and colorectal liver mestastases.
Topics: Antineoplastic Agents; Catheters, Indwelling; Colorectal Neoplasms; Controlled Clinical Trials as Topic; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusion Pumps, Implantable; Injections, Intra-Arterial; Liver Neoplasms; Research Design | 2003 |
Can colorectal cancer patients with thymidylate synthase-overexpressing liver metastases have an overall survival advantage with hepatic arterial infusion alone?
Topics: Antimetabolites, Antineoplastic; Colorectal Neoplasms; Disease Progression; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Prognosis; Survival Rate; Thymidylate Synthase | 2003 |
A comparative study of 5-fluorouracil (FU), 5-fluorodeoxyuridine (FUDR), and methotrexate (MTX)-progress report.
Topics: Antineoplastic Agents; Floxuridine; Fluorouracil; Folic Acid Antagonists; Methotrexate; Nucleosides; Nucleotides; Research Report; Uracil | 1962 |
[Studies on the mechanism of induction. IV. The effect of 5-bromouracil on induction with 5-fluorouracil and 5-fluorodeoxyuridine].
Topics: Bromouracil; Coliphages; Escherichia coli; Floxuridine; Fluorouracil; Uracil | 1963 |
[Studies on the mechanism of induction. I. The effect of some base analogs on lysogenic bacteria].
Topics: Bacteria; Culture Media; Escherichia coli; Floxuridine; Fluorouracil; Lysogeny; Thymidine | 1963 |
[Studies on the mechanism of induction. III. The effect of uracil on the induction effect of 5-fluorouracil and 5-fluorodeoxyuridine].
Topics: Coliphages; Culture Media; Escherichia coli; Floxuridine; Fluorouracil; Uracil | 1963 |
Ultraviolet absorption spectra and structure of halogenated uracils and their glycosides.
Topics: Floxuridine; Fluorouracil; Glycosides; Nucleosides; Uracil | 1963 |
In vitro synthesis of acidsoluble thymine compounds by human neoplastic tissues.
Topics: DNA; DNA, Neoplasm; Floxuridine; Fluorouracil; Humans; In Vitro Techniques; Neoplasms; Thymine | 1963 |
The coupled formation of deoxyribonucleic acid, nuclear ribonucleic acid and protein in animal-cell cultures.
Topics: Cell Culture Techniques; DNA; Floxuridine; Fluorouracil; Nucleosides; Proteins; RNA; Thymidine; Tissue Culture Techniques | 1962 |
On the replication of vaccinia virus.
Topics: DNA; DNA Replication; DNA, Viral; Floxuridine; Fluorouracil; Poliovirus; Vaccinia virus; Virus Cultivation | 1962 |
Controlled-dose therapy as an adjunct to surgery.
Topics: Carcinoma; Carcinoma 256, Walker; Floxuridine; Fluorouracil; Humans; Protein Deficiency | 1963 |
Chemotherapy of disseminated solid tumors.
Topics: Antineoplastic Agents; Floxuridine; Fluorouracil; Humans; Neoplasms | 1962 |
Ineffectiveness of 5-fluoro-2'-deoxyuridine in man after failure of 5-fluorouracil.
Topics: Deoxyuridine; Floxuridine; Fluorouracil; Folic Acid; Humans | 1963 |
Fluorinated pyrimidines in treatment of breast cancer patients with liver metastases.
Topics: Breast Neoplasms; Floxuridine; Fluorouracil; Humans; Liver Neoplasms; Pyrimidines | 1963 |
INHIBITION OF EHRLICH ASCITES TUMOR WITH 5-FLUOROURACIL AND OTHER AGENTS.
Topics: Animals; Antineoplastic Agents; Carcinoma; Carcinoma, Ehrlich Tumor; Floxuridine; Fluorouracil; Hydrocortisone; Mice; Pharmacology; Research | 1963 |
FACTORS AFFECTING PRIMARY AND SECONDARY ANTIBODY PRODUCTION BY SPLENIC TISSUES.
Topics: Animals; Antibody Formation; Cattle; Endotoxins; Floxuridine; Fluorouracil; gamma-Globulins; Hemagglutination; Hemagglutination Inhibition Tests; Hemagglutination Tests; Rabbits; Radiation Effects; Research; Spleen | 1963 |
[STUDIES ON THE MECHANISM OF INDUCTION. V. EXPERIMENTS ON ANALYSIS OF THE INDUCTIVE EFFECT OF HALOGENATED BASES AND THEIR DESOXYRIBONUCLEOSIDES].
Topics: Coliphages; Culture Media; Cytosine Nucleotides; Deoxyribonucleosides; Escherichia coli; Floxuridine; Fluorouracil; Halogenation; Uracil; Uracil Nucleotides | 1963 |
SUMMARY OF INFORMAL DISCUSSIONS ON THE ROLE OF PYRIMIDINE ANTAGONISTS FOLLOWING PAPERS BY DR. PRUSOFF AND DR. CALABRESI.
Topics: Antimetabolites; Antineoplastic Agents; Floxuridine; Fluorouracil; Idoxuridine; Neoplasms; Nucleosides; Pyrimidines | 1963 |
EFFECTS OF 5-FLUOROURACIL, ACTINOMYCIN D AND MITOMYCIN C ON THE INDUCTION OF THYMIDINE KINASE BY VACCINIA-INFECTED L-CELLS.
Topics: Dactinomycin; DNA; DNA, Viral; Enzyme Inhibitors; Floxuridine; Fluorouracil; Metabolism; Mice; Mitomycin; Mitomycins; Pharmacology; Phosphotransferases; Research; RNA; RNA, Viral; Thymidine; Thymidine Kinase; Tissue Culture Techniques; Tritium; Vaccinia; Vaccinia virus; Virus Cultivation | 1963 |
FLUORINATED PYRIMIDINES. XIX. SOME BIOLOGICAL EFFECTS OF 5-TRIFLUOROMETHYLURACIL AND 5-TRIFLUOROMETHYL-2'-DEOXYURIDINE ON ESCHERICHIA COLI AND BACTERIOPHAGE T4B.
Topics: Antimetabolites; Carbon Isotopes; Chromatography; Coliphages; Escherichia coli; Floxuridine; Fluorouracil; Metabolism; Mutation; Pharmacology; Pyrimidines; Research; Thymine; Trifluridine; Virus Cultivation | 1963 |
CHEMOTHERAPY OF METASTATIC LIVER CANCER BY PROLONGED HEPATIC-ARTERY INFUSION.
Topics: Alkaline Phosphatase; Bile Duct Neoplasms; Bilirubin; Chemotherapy, Cancer, Regional Perfusion; Colonic Neoplasms; Erythrocyte Count; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Liver Neoplasms; Methotrexate; Neoplasm Metastasis; Pancreatic Neoplasms; Rectal Neoplasms; Stomach Neoplasms; Sulfobromophthalein; Transaminases; Uterine Cervical Neoplasms | 1964 |
EFFECT OF WATER SOLUBLE VITAMINS AND THEIR ANALOGUES ON THE GROWTH OF CANDIDA ALBICANS. I. BIOTIN, PYRIDOXAMINE, PYRIDOXINE AND FLUORINATED PYRIMIDINES.
Topics: Amines; Ascorbic Acid; Biotin; Candida; Candida albicans; Culture Media; Floxuridine; Fluorouracil; Folic Acid; Metabolism; Pharmacology; Pyridoxamine; Pyridoxine; Pyrimidines; Research; Vitamin B 12; Vitamin B Complex; Vitamins | 1963 |
FURTHER CLINICAL COMPARISON BETWEEN 5-FLUOROURACIL (5-FU) AND 5-FLUORO-2' -DEOXYURIDINE (5-FUDR).
Topics: Brain Neoplasms; Breast Neoplasms; Diarrhea; Floxuridine; Fluorouracil; Geriatrics; Humans; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Neoplasm Metastasis; Stomatitis; Toxicology; Vomiting | 1963 |
CANCER CHEMOTHERAPY BY PROLONGED ARTERIAL INFUSION.
Topics: Angiography; Arm; Brachiocephalic Trunk; Brain Neoplasms; Carotid Arteries; Chemotherapy, Cancer, Regional Perfusion; Floxuridine; Fluorescent Dyes; Fluorouracil; Head and Neck Neoplasms; Hepatic Artery; Humans; Iliac Artery; Leg; Liver Neoplasms; Methotrexate; Neoplasms; Pelvic Neoplasms; Subclavian Artery; Temporal Arteries; Thoracic Neoplasms; Toxicology | 1964 |
EFFECTS OF 2'-DEOXY-5-FLUOROURIDINE (NSC-27640) AND 5-FLUOROURACIL (NSC-19893) ON CHILDHOOD LEUKEMIA.
Topics: Bone Marrow Examination; Child; Floxuridine; Fluorouracil; Leukemia; Leukopenia; Melena; Nausea; Toxicology; Uridine; Vomiting | 1964 |
EFFECTS OF SELECTED CYTOTOXIC AGENTS ON ANTIBODY PRODUCTION IN MAN; A PRELIMARY REPORT.
Topics: Agglutination; Antibody Formation; Biomedical Research; Cyclophosphamide; Cytotoxins; Floxuridine; Fluorouracil; Francisella tularensis; Hemagglutination; Mechlorethamine; Mercaptopurine; Skin Tests | 1964 |
ACUTE GASTRITIS RESULTING FROM REGIONAL INFUSION OF AN ANTIMETABOLITE.
Topics: Adenocarcinoma; Angiography; Antimetabolites; Chemotherapy, Cancer, Regional Perfusion; Diagnosis, Differential; Floxuridine; Fluorouracil; Gastritis; Gastroscopy; Humans; Liver Neoplasms; Stomach Neoplasms; Toxicology | 1963 |
CHEMOTHERAPY OF COLON CANCER.
Topics: Androgens; Colonic Neoplasms; Cortisone; Floxuridine; Fluorouracil; Hydrochlorothiazide; Pyrimidines; Spironolactone; Toxicology | 1964 |
RATIONALE FOR THE DESIGN OF FLUORINATED PYRIMIDINES.
Topics: Animals; Antimetabolites; DNA; Floxuridine; Fluorouracil; Halogenation; Ligases; Mice; Neoplasms; Neoplasms, Experimental; Pharmacology; Pyrimidines; Rats; Research; RNA | 1964 |
THE CLINICAL EFFECTS OF THE CONTINUOUS INTRAVENOUS INFUSION OF CANCER CHEMOTHERAPEUTIC COMPOUNDS.
Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Antineoplastic Agents; Floxuridine; Fluorouracil; Infusions, Intravenous; Infusions, Parenteral; Methotrexate; Mitomycin; Mitomycins; Neoplasms; Thymidine | 1964 |
INDIVIDUALIZED CHEMOTHERAPY BY IN VITRO DRUG SELECTION.
Topics: Antineoplastic Agents; Bone Neoplasms; Dactinomycin; Female; Floxuridine; Fluorouracil; Genital Neoplasms, Female; Humans; In Vitro Techniques; Intestinal Neoplasms; Leukemia; Mechlorethamine; Melanoma; Mercaptopurine; Methotrexate; Neoplasms; Pharyngeal Neoplasms; Respiratory Tract Neoplasms; Stomach Neoplasms; Thiotepa | 1964 |
THE EFFECT OF NATURAL AND UNNNATURAL PYRIMIDINES AND PYRIMIDINE NUCLEOSIDES ON THE PHOSPHOROLYSIS OF 5-IODODEOXYURIDINE BY MOUSE LIVER EXTRACT.
Topics: Animals; Chromatography; Deoxyuridine; Floxuridine; Fluorouracil; Idoxuridine; Iodine Isotopes; Liver; Liver Extracts; Metabolism; Mice; Nucleosides; Pharmacology; Phosphotransferases; Pyrimidine Nucleosides; Pyrimidines; Research; Thymidine; Thymine; Uracil | 1964 |
INCOMPLETE SIMIAN PAPOVAVIRUS SV40. FORMATION OF NON-INFECTIOUS VIRAL ANTIGEN IN THE PRESENCE OF FLUOROURACIL.
Topics: Animals; Antigens; Antigens, Viral; Cell Nucleus; Electrons; Floxuridine; Fluorescence; Fluorescent Antibody Technique; Fluorouracil; Haplorhini; Kidney; Microscopy; Microscopy, Electron; Microscopy, Fluorescence; Oncogenic Viruses; Pharmacology; Research; Simian virus 40; Tissue Culture Techniques; Viral Proteins; Virus Cultivation | 1964 |
PROTRACTED AMBULATORY INFUSION CANCER CHEMOTHERAPY BY THE WATKINS CHRONOMETRIC INFUSOR.
Topics: Adenoma; Antineoplastic Agents; Breast Neoplasms; Carcinosarcoma; Colonic Neoplasms; Dermatitis, Exfoliative; Equipment and Supplies; Floxuridine; Fluorouracil; Humans; Infusion Pumps; Infusions, Parenteral; Lung Neoplasms; Lymphoma, Non-Hodgkin; Male; Melanoma; Methotrexate; Mitomycin; Mitomycins; Pancreatic Neoplasms; Stomach Neoplasms; Testicular Neoplasms; Thyroid Neoplasms; Tongue Neoplasms; Toxicology | 1964 |
RESPONSE OF PRIMARY UNKNOWN CANCERS TO TREATMENT WITH 5-FLUOROURACIL (NSC-19893).
Topics: Adolescent; Biomedical Research; Child; Cyclophosphamide; Floxuridine; Fluorouracil; Geriatrics; Neoplasm Metastasis; Neoplasms; Neoplasms, Unknown Primary; Toxicology; Wisconsin | 1964 |
A COMPARISON OF THE EFFECTS OF SELECTED CYTOTOXIC AGENTS ON THE PRIMARY AGGLUTININ RESPONSE IN RATS INJECTED WITH SHEEP ERYTHROCYTES.
Topics: Agglutinins; Animals; Antibodies; Antibody Formation; Antigen-Antibody Reactions; Antigens; Antineoplastic Agents; Cyclophosphamide; Cytotoxins; Erythrocytes; Floxuridine; Fluorouracil; Immunity; Immunization; Mechlorethamine; Mercaptopurine; Methotrexate; Purines; Rats; Research; Sheep; Toxicology; Vinblastine | 1964 |
CEREBELLAR ATAXIA ASSOCIATED WITH FLUORINATED PYRIMIDINE THERAPY.
Topics: Ataxia; Cerebellar Ataxia; Cerebellar Diseases; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Neoplasms; Pyrimidines; Toxicology | 1964 |
A LESS TOXIC FLUOROURACIL DOSAGE SCHEDULE.
Topics: Alopecia; Breast Neoplasms; Colonic Neoplasms; Diarrhea; Drug Eruptions; Epistaxis; Female; Floxuridine; Fluorouracil; Humans; Leukopenia; Liver Neoplasms; Neoplasms; Ovarian Neoplasms; Rectal Neoplasms; Toxicology; Uterine Cervical Neoplasms | 1964 |
LYSOGENIC CONVERSION BY BACTERIOPHAGE P2 RESULTING IN AN INCREASED SENSITIVITY OF ESCHERICHIA COLI TO 5-FLUORODEOXYURIDINE.
Topics: Alcohols; Anti-Bacterial Agents; Bacteriophage P2; Coliphages; Dermatologic Agents; Escherichia coli; Floxuridine; Fluorouracil; Muramidase; Nucleosides; Penicillins; Pharmacology; Research; Sucrose | 1964 |
ANTIMITOTIC EFFECTS OF CHLORAMPHENICOL AND OTHER INHIBITORY AGENTS IN CHLAMYDOMONAS.
Topics: Antimitotic Agents; Cell Division; Cell Nucleus; Chlamydia; Chlamydomonas; Chloramphenicol; Chlorides; DNA; Floxuridine; Fluorouracil; Glycols; Mercaptoethanol; Nucleosides; Pharmacology; Proteins; Radiation Effects; Research; RNA; Uracil | 1964 |
[RESEARCH ON THE MECHANISM OF INDUCTION. 8. THE EFFECT OF 5-FLUOROURACIL ON INDUCTION BY MEANS OF THYMINE DEFICIENCY].
Topics: Bacteriolysis; Coliphages; Floxuridine; Fluorouracil; Genetics; Pharmacology; Research; Thymine | 1964 |
CANCER CHEMOTHERAPY OF THE GASTROINTESTINAL TRACT WITH REFERENCE TO INTRA-ARTERIAL INFUSION AND IRRADIATION.
Topics: Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Cobalt Isotopes; Cyclophosphamide; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Humans; Infusions, Intra-Arterial; Injections, Intra-Arterial; Neoplasm Metastasis; Neoplasms; Palliative Care; Radiotherapy, High-Energy; Toxicology | 1965 |
FLUORINATED PYRIMIDINES. XXII. EFFECTS OF VARIOUS COMPOUNDS ON THE INCORPORATION OF (14C)FORMATE INTO DNA THYMINE IN SUSPENSIONS OF EHRLICH ASCITES CELLS.
Topics: Animals; Antineoplastic Agents; Ascites; Carbon Isotopes; Carcinoma; Carcinoma, Ehrlich Tumor; DNA; DNA, Neoplasm; Floxuridine; Fluorouracil; Formates; Metabolism; Mutagens; Pharmacology; Pyrimidines; Research; Suspensions; Thymine; Tissue Culture Techniques | 1964 |
FLUORESCENCE MICROSCOPY OF POLYOMA-INFECTED CELLS TREATED WITH HALOGENATED PYRIMIDINE ANALOGUES.
Topics: Antimetabolites; Floxuridine; Fluorescence; Fluorouracil; Idoxuridine; Mice; Microscopy; Microscopy, Fluorescence; Nucleosides; Pharmacology; Polyomavirus; Pyrimidines; Research; Toxicology; Virus Diseases | 1964 |
BIOCHEMICALLY MARKED VARIANTS OF THE SYRIAN HAMSTER FIBROBLAST CELL LINE BHK21 AND ITS DERIVATIVES.
Topics: 2-Aminopurine; Amphotericin B; Animals; Antineoplastic Agents; Azaguanine; Bromodeoxyuridine; Carbon Isotopes; Cell Division; Cell Line; Cricetinae; Dactinomycin; Fibroblasts; Floxuridine; Fluorouracil; Hexoses; Hypoxanthines; Mercaptopurine; Mesocricetus; Metabolism; Mitomycin; Mitomycins; Mutation; Nucleosides; Pharmacology; Puromycin; Research; Thioguanine; Tissue Culture Techniques; Tritium; Vinblastine | 1965 |
PYRIMIDINE METABOLISM IN TISSUE CULTURE CELLS DERIVED FROM RAT HEPATOMAS. I. SUSPENSION CELL CULTURES DERIVED FROM THE NOVIKOFF HEPATOMA.
Topics: Animals; Carcinoma, Hepatocellular; Cell Culture Techniques; Floxuridine; Fluorouracil; Glycine; Liver Neoplasms; Liver Neoplasms, Experimental; Metabolism; Methotrexate; Mutation; Neoplasms; Neoplasms, Experimental; Nucleosides; Pharmacology; Pyrimidines; Rats; Research; Serine; Thymidine; Thymidine Kinase; Thymine; Tissue Culture Techniques; Toxicology; Uracil | 1965 |
SYSTEMIC CHEMOTHERAPY FOR CNS METASTASES OF SOLID TUMORS.
Topics: Adenocarcinoma; Brain Neoplasms; Breast Neoplasms; Cyclophosphamide; Drug Therapy; Floxuridine; Fluorouracil; Humans; Lung Neoplasms; Neoplasm Metastasis; Neoplasms; Palliative Care; Spinal Cord Neoplasms | 1965 |
EFFECT OF SPLENECTOMY ON TOLERANCE TO FLUORINATED PYRIMIDINES.
Topics: Dogs; Drug Tolerance; Floxuridine; Fluorouracil; Gastrectomy; Immune Tolerance; Pharmacology; Pyrimidines; Research; Splenectomy; Toxicology | 1965 |
DIFFERENTIAL EFFECTS OF INHIBITORS ON THE STEPS LEADING TO THE FORMATION OF SV40 TUMOR AND VIRUS ANTIGENS.
Topics: Animals; Antigens; Antigens, Viral; Antimetabolites; Chlorocebus aethiops; Complement Fixation Tests; Dactinomycin; DNA, Viral; Floxuridine; Fluorescence; Fluorescent Antibody Technique; Fluorouracil; Idoxuridine; Microscopy; Microscopy, Fluorescence; Mitomycin; Neoplasms; Nucleosides; Pharmacology; Phenylalanine; Puromycin; Research; Simian virus 40; Tissue Culture Techniques; Virus Cultivation | 1965 |
Effects of 5-fluorodeoxyuridine and related halogenated pyrimidines on the sand-dollar embryo.
Topics: Cytidine; DNA; Female; Floxuridine; Fluorouracil; Humans; Orotic Acid; Pregnancy; Pyrimidines; Thymidine; Thymine; Uridine | 1960 |
Studies on the feasibility of adjuvant chemotherapy with 5-fluorouracil (FU) and 5-fluoro-2'-deoxyuridine (FUDR) in the immediate postoperative period.
Topics: Antineoplastic Agents; Chemotherapy, Adjuvant; Deoxyuridine; Floxuridine; Fluorouracil; Humans; Postoperative Period; Pyrimidines; Uracil | 1962 |
Reversal of toxicity of 5-fluorouracil and 5-fluorodeoxyuridine for Candida albicans by pyridoxine and pyridoxamine.
Topics: Candida; Candida albicans; Floxuridine; Fluorouracil; Nucleosides; Nucleotides; Pyridoxamine; Pyridoxine | 1961 |
Pharmacokinetics of 5-fluorouracil following hepatic intra-arterial infusion in a VX2 hepatic metastasis model.
Topics: Animals; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Disease Models, Animal; Drug Administration Schedule; Floxuridine; Fluorouracil; Hepatic Artery; Infusions, Intra-Arterial; Liver Neoplasms; Rabbits; Tissue Distribution | 2003 |
ZD1839 (Iressa) modifies the activity of key enzymes linked to fluoropyrimidine activity: rational basis for a new combination therapy with capecitabine.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Cell Cycle; Cell Division; Cell Line, Tumor; Cell Survival; Deoxycytidine; DNA Primers; Floxuridine; Fluorouracil; Gefitinib; Head and Neck Neoplasms; Humans; Models, Chemical; Polymerase Chain Reaction; Pyrimidines; Quinazolines; RNA; RNA, Messenger; Time Factors; Transcription, Genetic | 2003 |
[A case of hepatic metastasis and local recurrence from rectal cancer responding to hepatic arterial infusion and systemic chemotherapy].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Drug Administration Schedule; Drug Combinations; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Irinotecan; Leucovorin; Liver Neoplasms; Male; Neoplasm Recurrence, Local; Rectal Neoplasms; Tegafur; Uracil | 2003 |
In vivo monitoring of capecitabine metabolism in human liver by 19fluorine magnetic resonance spectroscopy at 1.5 and 3 Tesla field strength.
Topics: Aged; Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Female; Floxuridine; Fluorine; Fluorouracil; Humans; Liver; Liver Neoplasms; Magnetic Resonance Spectroscopy; Male; Middle Aged; Prodrugs | 2003 |
Enzyme-prodrug systems: thymidine phosphorylase/5'-deoxy-5-fluorouridine.
Topics: Animals; Antimetabolites, Antineoplastic; Biotransformation; Cell Line; Coculture Techniques; DNA, Complementary; Floxuridine; Fluorouracil; Genetic Therapy; Genetic Vectors; Humans; Mammals; Restriction Mapping; Thymidine Phosphorylase; Transfection; Tritium; Tumor Cells, Cultured | 2004 |
Correlation of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase with sensitivity of gastrointestinal cancer cells to 5-fluorouracil and 5-fluoro-2'-deoxyuridine.
Topics: Antimetabolites, Antineoplastic; Cell Line, Tumor; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Drug Resistance, Neoplasm; Enzymes; Floxuridine; Fluorouracil; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Stomach Neoplasms; Thymidine Phosphorylase; Thymidylate Synthase | 2004 |
Cytotoxic chemotherapy for metastatic renal cell carcinoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Carcinoma, Renal Cell; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Deoxycytidine; Floxuridine; Fluorouracil; Gemcitabine; Humans; Kidney Neoplasms; Neoplasm Metastasis; Survival Rate | 2004 |
Bioactivation of capecitabine in human liver: involvement of the cytosolic enzyme on 5'-deoxy-5-fluorocytidine formation.
Topics: Antimetabolites, Antineoplastic; Capecitabine; Cytosol; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Floxuridine; Fluorouracil; Humans; In Vitro Techniques; Microsomes, Liver; Prodrugs; Pyridines; Thymidine Phosphorylase | 2004 |
Effects of oxaliplatin and CPT-11 on cytotoxicity and nucleic acid incorporation of the fluoropyrimidines.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Drug Synergism; Floxuridine; Fluorouracil; Humans; Irinotecan; Nucleic Acids; Organoplatinum Compounds; Oxaliplatin; Uridine | 2004 |
The HPV16 E6/E7 oncogene sensitizes human ovarian surface epithelial cells to low-dose but not high-dose 5-FU and 5-FUdR.
Topics: Apoptosis; Cell Line, Tumor; Dose-Response Relationship, Drug; Epithelial Cells; Female; Floxuridine; Fluorouracil; Humans; Oncogene Proteins, Viral; Ovarian Neoplasms; Recombinant Proteins; Thymidylate Synthase | 2004 |
Intra-aortal therapy with 5-fluorouracil- polyethylene glycol stealth liposomes: does the metabolism of 5-fluorouracil into 5-fluoro-2'-deoxyuridine depend on ph value?. An animal study in VX-2 liver tumor-bearing rabbits.
Topics: Animals; Antimetabolites, Antineoplastic; Aorta, Abdominal; Cell Line, Tumor; Chromatography, High Pressure Liquid; Floxuridine; Fluorouracil; Hydrogen-Ion Concentration; In Vitro Techniques; Liposomes; Liver; Liver Neoplasms, Experimental; Male; Polyethylene Glycols; Rabbits; Tissue Distribution | 2004 |
S-1-induced, prolonged complete regression of lung metastasis from gastric cancer refractory to 5'-DFUR: a case report with pharmacokinetic study.
Topics: Adenocarcinoma, Mucinous; Administration, Oral; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Drug Administration Schedule; Drug Combinations; Esophagectomy; Female; Floxuridine; Fluorouracil; Gastrectomy; Humans; Lung Neoplasms; Middle Aged; Oxonic Acid; Pyridines; Radiography, Thoracic; Remission Induction; Stomach Neoplasms; Tegafur; Tomography, X-Ray Computed | 2004 |
Hepatic artery infusion chemotherapy for metastatic colorectal cancer to the liver at the lahey clinic: comparison between two methods of treatment, surgical versus percutaneous catheter placement.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Brachial Artery; Catheterization, Peripheral; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusion Pumps; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Survival Analysis | 2004 |
A novel combination antimetabolite, TAS-102, exhibits antitumor activity in FU-resistant human cancer cells through a mechanism involving FTD incorporation in DNA.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Colonic Neoplasms; DNA Damage; DNA, Neoplasm; Drug Combinations; Drug Resistance, Neoplasm; Floxuridine; Fluorouracil; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Pyrrolidines; Rats; Rats, Nude; Stomach Neoplasms; Thymine; Trifluridine; Uracil; Xenograft Model Antitumor Assays | 2004 |
[Enhancement effect of interferon gamma on the sensitivity of RT4 bladder cancer cells to 5'-deoxy-5-fluorouridine,and 5-fluorouracil through up-regulation of PD-ECGF/TP].
Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Synergism; Floxuridine; Fluorouracil; Humans; Interferon-gamma; RNA, Messenger; Thymidine Phosphorylase; Up-Regulation; Urinary Bladder Neoplasms | 2004 |
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
Topics: Antineoplastic Agents; beta-Alanine; Cell Line, Tumor; Dihydrouracil Dehydrogenase (NADP); Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Foot Dermatoses; Hand Dermatoses; Humans; Inhibitory Concentration 50; Keratinocytes; Syndrome; Thymidine Phosphorylase | 2004 |
[A case of disseminated tumor from cecal cancer with survival for over 5 years after twice surgical resection and systemic chemotherapy].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoembryonic Antigen; Cecal Neoplasms; Combined Modality Therapy; Floxuridine; Fluorouracil; Humans; Irinotecan; Leucovorin; Male; Neoplasm Seeding; Peritoneal Neoplasms; Reoperation | 2004 |
[A case of long-term survival after chemo-radiation for postoperative local recurrence of rectal cancer].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Radiotherapy Dosage; Rectal Neoplasms | 2004 |
A non-radioactive sensitive assay to measure 5-fluorouracil incorporation into DNA of solid tumors.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Colonic Neoplasms; DNA; Drug Screening Assays, Antitumor; Floxuridine; Fluorouracil; Gas Chromatography-Mass Spectrometry; Mice; Neoplasms; Sensitivity and Specificity; Time Factors | 2004 |
Comparative antitumor activity of 5-fluorouracil and 5'-deoxy-5-fluorouridine in combination with interferon-alpha in renal cell carcinoma cell lines.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Drug Screening Assays, Antitumor; Floxuridine; Fluorouracil; Humans; Interferon-alpha; Kidney Neoplasms; Tumor Cells, Cultured | 2004 |
[Successful combination therapy with 5'-DFUR and MPA for breast cancer with spinal and vertebral metastases].
Topics: Adenocarcinoma, Scirrhous; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Magnetic Resonance Imaging; Mastectomy; Medroxyprogesterone Acetate; Middle Aged; Remission Induction; Spinal Cord Neoplasms; Spinal Neoplasms | 2004 |
[Significance of tissue thymidine phosphorylase and dihydropyrimidine dehydrogenase activities in ovarian cancer].
Topics: 5'-Nucleotidase; Adenocarcinoma, Scirrhous; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Female; Floxuridine; Fluorouracil; Humans; Middle Aged; Ovarian Neoplasms; Survival Rate | 2004 |
Thymidine phosphorylase expression and efficacy of adjuvant doxifluridine in advanced colorectal cancer patients.
Topics: Administration, Oral; Aged; Antibodies, Monoclonal; Antimetabolites, Antineoplastic; Cell Differentiation; Cell Line, Tumor; Chemotherapy, Adjuvant; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Immunohistochemistry; Male; Middle Aged; Prognosis; Risk; Thymidine Phosphorylase; Time Factors; Treatment Outcome | 2005 |
The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites.
Topics: Adenosine Triphosphate; Antimetabolites, Antineoplastic; Apoptosis; Biological Transport; Cells, Cultured; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Floxuridine; Fluorouracil; Humans; Kidney; Multidrug Resistance-Associated Proteins; Phosphorylation; Thioguanine; Thymidylate Synthase | 2005 |
Polymorphic tandem repeat sequences of the thymidylate synthase gene correlates with cellular-based sensitivity to fluoropyrimidine antitumor agents.
Topics: Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Proliferation; Floxuridine; Fluorouracil; Gene Expression Regulation, Enzymologic; Genotype; Humans; Luciferases; Polymorphism, Genetic; RNA, Messenger; Tandem Repeat Sequences; Thymidylate Synthase | 2005 |
Effects of oral 5-fluorouracil drugs on hepatic fat content in patients with colon cancer.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Chi-Square Distribution; Colonic Neoplasms; Fatty Liver; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Retrospective Studies; Tegafur; Tomography, X-Ray Computed; Uracil | 2005 |
Correlations between antitumor activities of fluoropyrimidines and DPD activity in lung tumor xenografts.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Cell Line, Tumor; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Floxuridine; Fluorouracil; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Orotate Phosphoribosyltransferase; Oxonic Acid; Pyridines; Tegafur; Thymidine Phosphorylase; Treatment Outcome; Uracil; Xenograft Model Antitumor Assays | 2005 |
5-Fluorouracil concentration in blood, liver and tumor tissues and apoptosis of tumor cells after preoperative oral 5'-deoxy-5-fluorouridine in patients with hepatocellular carcinoma.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Carcinoma, Hepatocellular; Female; Floxuridine; Fluorouracil; Humans; Liver; Liver Neoplasms; Male; Middle Aged; Preoperative Care | 2005 |
Preferential inhibition of bone metastases by 5'-deoxy-5-fluorouridine and capecitabine in the 4T1/luc mouse breast cancer model.
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Capecitabine; Cell Line, Tumor; Deoxycytidine; Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Luciferases; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Time Factors; Transfection; Treatment Outcome | 2005 |
[Experience with capecitabine in patients with anthracycline and/or taxane-resistant recurrent breast cancer].
Topics: Administration, Oral; Anthracyclines; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Deoxycytidine; Drug Resistance, Neoplasm; Female; Floxuridine; Fluorouracil; Humans; Middle Aged; Taxoids | 2005 |
Improvement in 5-fluorouracil (5-FU) and 5-fluoro-2'-deoxyuridine (FdUrd) concentration by 5-fluorouracil-polyethylene-glycol-liposomes in abdominal stop-flow: treatment of VX2 liver-tumor-bearing rabbits.
Topics: Animals; Biological Availability; Blood Flow Velocity; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Floxuridine; Fluorouracil; Hydrogen-Ion Concentration; Infusions, Intra-Arterial; Infusions, Intravenous; Liposomes; Liver Neoplasms, Experimental; Male; Oxygen Consumption; Probability; Rabbits; Risk Factors; Sensitivity and Specificity | 2005 |
Simultaneous determination of capecitabine and its metabolites by HPLC and mass spectrometry for preclinical and clinical studies.
Topics: Animals; Capecitabine; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Deoxycytidine; Drug Stability; Floxuridine; Fluorouracil; Humans; Liver; Mice; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2005 |
[Case report--postoperative continuous intraarterial infusion of small doses of 5-FU successfully controlled residual tumor and liver metastasis of stage IV gastric cancer].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Disease-Free Survival; Doxorubicin; Drug Combinations; Floxuridine; Fluorouracil; Gastrectomy; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Lymph Node Excision; Lymph Nodes; Lymphatic Metastasis; Male; Methotrexate; Mitomycin; Neoplasm Staging; Picibanil; Proteoglycans; Stomach Neoplasms; Tegafur; Uracil | 2005 |
Perfusion chemotherapy for colorectal liver metastases: a randomized study comparing FUDR against 5-FU/BCNU.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carmustine; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Liver Neoplasms; Neoplasm Metastasis; Randomized Controlled Trials as Topic; Treatment Outcome | 1989 |
Predicting toxicity during 5-fluorocytosine (5-FC) therapy by plasma level monitoring: a lesson to learn from cytostatic 5-fluorouracil (5 FU) pro-drugs.
Topics: Antimetabolites; Floxuridine; Flucytosine; Fluorouracil; Humans; Metabolic Clearance Rate; Monitoring, Physiologic; Prodrugs | 1989 |
[Pharmacokinetic comparison of capecitabine and 5'-deoxy-5-fluorouridine (doxifluridine; 5'-DFUR)].
Topics: Antimetabolites, Antineoplastic; Area Under Curve; Breast Neoplasms; Capecitabine; Clinical Trials, Phase II as Topic; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Prodrugs | 2005 |
Upregulation of thymidine phosphorylase in rectal cancer tissues by mitomycin C.
Topics: Adult; Aged; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chemotherapy, Adjuvant; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Disease-Free Survival; Female; Floxuridine; Fluorouracil; Humans; Immunohistochemistry; Male; Middle Aged; Mitomycin; Rectal Neoplasms; Thymidine Phosphorylase; Up-Regulation | 2006 |
Modulation of uridine phosphorylase gene expression by tumor necrosis factor-alpha enhances the antiproliferative activity of the capecitabine intermediate 5'-deoxy-5-fluorouridine in breast cancer cells.
Topics: Animals; Base Sequence; Capecitabine; Deoxycytidine; DNA Primers; Drug Synergism; Electrophoretic Mobility Shift Assay; Floxuridine; Fluorouracil; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Mammary Neoplasms, Experimental; Mice; NF-kappa B; Tumor Necrosis Factor-alpha; Uridine Phosphorylase | 2006 |
Induction of thymidine phosphorylase expression by AZT contributes to enhancement of 5'-DFUR cytotoxicity.
Topics: Antimetabolites; Cell Survival; Drug Synergism; Floxuridine; Fluorouracil; Humans; Thymidine Phosphorylase; Transfection; U937 Cells; Zidovudine | 2006 |
Chemotherapy-induced sclerosing cholangitis: long-term response to endoscopic therapy.
Topics: Adult; Aged; Alkaline Phosphatase; Antineoplastic Combined Chemotherapy Protocols; Cholangiopancreatography, Endoscopic Retrograde; Cholangitis, Sclerosing; Colonic Neoplasms; Constriction, Pathologic; Female; Floxuridine; Fluorouracil; Hepatic Duct, Common; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Palliative Care; Retrospective Studies; Treatment Outcome | 2006 |
The role of thymidine phosphorylase and uridine phosphorylase in (fluoro)pyrimidine metabolism in peripheral blood mononuclear cells.
Topics: Cells, Cultured; Floxuridine; Fluorouracil; Humans; Inhibitory Concentration 50; Leukocytes, Mononuclear; Pyrimidines; RNA; Substrate Specificity; Thymidine; Thymidine Phosphorylase; Uridine Phosphorylase | 2006 |
Relationship between AUC of 5'-DFUR and toxicity of capecitabine, fluoropyrimidine carbamate analogs, and 5'-DFUR in monkeys, mice, and rats.
Topics: Animals; Antimetabolites, Antineoplastic; Area Under Curve; Capecitabine; Carbamates; Deoxycytidine; Floxuridine; Fluorouracil; Intestines; Macaca fascicularis; Male; Mice; Rats; Rats, Sprague-Dawley | 2006 |
Irinotecan cytotoxicity does not necessarily depend on the UGT1A1 polymorphism but on fluoropyrimidine: a molecular case report.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Glucuronosyltransferase; Humans; Irinotecan; Polymorphism, Genetic | 2006 |
Genomic copy number changes affecting the thymidylate synthase (TYMS) gene in cancer: a model for patient classification to aid fluoropyrimidine therapy.
Topics: 5' Untranslated Regions; Alleles; Antimetabolites, Antineoplastic; Cell Line, Tumor; Colorectal Neoplasms; DNA, Complementary; Drug Resistance, Neoplasm; Floxuridine; Fluorouracil; Gene Dosage; Gene Targeting; Genotype; Humans; Loss of Heterozygosity; Neoplasm Proteins; Pancreatic Neoplasms; Patient Selection; Tandem Repeat Sequences; Thymidylate Synthase; Transplantation, Heterologous | 2006 |
[Effectiveness of preoperative chemoradiotherapy for advanced rectal cancer].
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Staging; Pelvis; Preoperative Care; Radiotherapy Dosage; Radiotherapy, Adjuvant; Rectal Neoplasms; Rectum; Survival Rate | 2006 |
Thymidylate synthase as a chemotherapeutic drug target: where are we after fifty years?
Topics: Animals; Antimetabolites, Antineoplastic; Drug Delivery Systems; Enzyme Inhibitors; Floxuridine; Fluorouracil; Humans; Mice; Thymidylate Synthase | 2006 |
Tezacitabine enhances the DNA-directed effects of fluoropyrimidines in human colon cancer cells and tumor xenografts.
Topics: Apoptosis; Cell Line, Tumor; Colonic Neoplasms; Deoxycytidine; DNA; DNA Damage; Floxuridine; Fluorouracil; Humans; Thymidine Phosphorylase; Thymidylate Synthase; Transplantation, Heterologous | 2007 |
Rapid and simultaneous determination of capecitabine and its metabolites in mouse plasma, mouse serum, and in rabbit bile by high-performance liquid chromatography.
Topics: Animals; Bile; Calibration; Capecitabine; Chromatography, High Pressure Liquid; Deoxycytidine; Floxuridine; Fluorouracil; Mice; Plasma; Rabbits; Reproducibility of Results; Serum | 2007 |
The Hollow Fibre Assay as a model for in vivo pharmacodynamics of fluoropyrimidines in colon cancer cells.
Topics: Administration, Oral; Animals; Apoptosis; Capecitabine; Cell Cycle; Cell Line, Tumor; Colonic Neoplasms; Deoxycytidine; Drug Combinations; Drug Synergism; Enzyme Inhibitors; Flow Cytometry; Floxuridine; Fluorouracil; Humans; Mice; Mice, Inbred BALB C; Pyrrolidines; Sensitivity and Specificity; Thymidine Phosphorylase; Thymine; Treatment Outcome; Trifluridine; Tumor Cells, Cultured; Uracil; Xenograft Model Antitumor Assays | 2007 |
[A case of colon cancer liver metastases treated by combined therapies].
Topics: Antineoplastic Combined Chemotherapy Protocols; Catheter Ablation; Chemotherapy, Adjuvant; Colon, Sigmoid; Combined Modality Therapy; Floxuridine; Fluorouracil; Hepatectomy; Humans; Jaundice, Obstructive; Leucovorin; Liver Neoplasms; Lymph Node Excision; Male; Middle Aged; Sigmoid Neoplasms; Stents; Tegafur | 2006 |
[Evaluation of combination therapy of high-dose toremifene and oral chemotherapy].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Cyclophosphamide; Deoxycytidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Female; Floxuridine; Fluorouracil; Humans; Liver Neoplasms; Lung Neoplasms; Lymph Nodes; Lymphatic Metastasis; Middle Aged; Neoplasm Recurrence, Local; Oxonic Acid; Quality of Life; Skin Neoplasms; Tegafur; Toremifene | 2007 |
Development and characterization of a model of liver metastasis using human colon cancer HCT-116 cells.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Adhesion; Cell Line, Tumor; Collagen Type II; Colonic Neoplasms; Female; Fibronectins; Floxuridine; Fluorouracil; Humans; Irinotecan; Laminin; Liver Neoplasms; Mice; Mice, Inbred C57BL; Mice, Nude; Models, Biological; Neoplasm Metastasis; Paclitaxel | 2007 |
Assessing the optimal duration of chemotherapy in patients with colorectal liver metastases.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Dexamethasone; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Irinotecan; Leucovorin; Liver Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Retrospective Studies; Time Factors; Treatment Outcome | 2008 |
Hepatic arterial infusion chemotherapy for metastases from colorectal cancer: is it really the end of an era?
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Liver Neoplasms | 2008 |
Immunochemotherapy with PSK and fluoropyrimidines improves long-term prognosis for curatively resected colorectal cancer.
Topics: Aged; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Combined Modality Therapy; Drug Combinations; Female; Floxuridine; Fluorouracil; Humans; Immunotherapy; Kaplan-Meier Estimate; Male; Middle Aged; Prognosis; Proportional Hazards Models; Proteoglycans; Retrospective Studies; Tegafur; Uracil | 2008 |
Simultaneous determination of doxifluridine and 5-fluorouracil in monkey serum by high performance liquid chromatography with tandem mass spectrometry.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Chromatography, High Pressure Liquid; Drug Stability; Floxuridine; Fluorouracil; Linear Models; Macaca fascicularis; Male; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2008 |
Challenge of high polarity and low concentrations in analysis of cytostatics and metabolites in wastewater by hydrophilic interaction chromatography/tandem mass spectrometry.
Topics: Adsorption; Chromatography, Liquid; Cytostatic Agents; Deoxycytidine; Drug Residues; Floxuridine; Fluorouracil; Gemcitabine; Hydrophobic and Hydrophilic Interactions; Linear Models; Models, Molecular; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Tandem Mass Spectrometry; Water; Water Pollutants, Chemical | 2009 |
[Preparation of floxuridine loaded polycation and its antitumor activity].
Topics: Antimetabolites, Antineoplastic; beta-Cyclodextrins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Floxuridine; Fluorouracil; Humans; Liver Neoplasms; Polyethyleneimine; Prodrugs | 2009 |
Postoperative chemotherapy after neoadjuvant chemoradiation and surgery for rectal cancer: is it essential for patients with ypT0-2N0?
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Floxuridine; Fluorouracil; Follow-Up Studies; Humans; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Rectal Neoplasms; Retrospective Studies; Tegafur; Uracil | 2009 |
Simultaneous quantification of 5-FU, 5-FUrd, 5-FdUrd, 5-FdUMP, dUMP and TMP in cultured cell models by LC-MS/MS.
Topics: Cell Line; Cell Line, Tumor; Chromatography, Liquid; Deoxyuracil Nucleotides; Drug Stability; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Tandem Mass Spectrometry; Thymidine Monophosphate | 2009 |
A new, validated HPLC-MS/MS method for the simultaneous determination of the anti-cancer agent capecitabine and its metabolites: 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, 5-fluorouracil and 5-fluorodihydrouracil, in human plasma.
Topics: 1-Propanol; Acetonitriles; Antimetabolites, Antineoplastic; Capecitabine; Chemical Precipitation; Chromatography, High Pressure Liquid; Deoxycytidine; Drug Stability; Floxuridine; Fluorouracil; Furans; Humans; Linear Models; Pyrimidines; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Trichloroacetic Acid; Uracil; Vidarabine | 2010 |
Mass flows of X-ray contrast media and cytostatics in hospital wastewater.
Topics: Contrast Media; Cytostatic Agents; Deoxycytidine; Environmental Monitoring; Floxuridine; Fluorouracil; Gemcitabine; Hospitals; Medical Waste Disposal; Waste Disposal, Fluid; Water Pollutants; Water Pollution, Chemical; Water Purification; X-Rays | 2009 |
Hepatic arterial infusion for unresectable colorectal liver metastases combined or not with systemic chemotherapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cohort Studies; Colorectal Neoplasms; Dexamethasone; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Male; Middle Aged; Retrospective Studies; Survival Rate; Treatment Outcome | 2009 |
Increased anticoagulant activity of warfarin used in combination with doxifluridine.
Topics: Administration, Oral; Aged; Anticoagulants; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Humans; International Normalized Ratio; Warfarin | 2010 |
In defense of hepatic arterial infusion for hepatic metastases of colorectal cancer.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Dexamethasone; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Survival Analysis; United States | 2010 |
Plasma disposition of capecitabine (CCB) and its metabolites 5'-deoxy-5-fluorocytidine (5'-DFCR) and 5'-deoxy-5-fluorouracil (5'-DFUR) with two different capecitabine/oxaliplatin dosage regimens.
Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Floxuridine; Fluorouracil; Humans; Organoplatinum Compounds; Oxaliplatin | 2010 |
Vorinostat synergises with capecitabine through upregulation of thymidine phosphorylase.
Topics: Animals; Antineoplastic Agents; Apoptosis; Capecitabine; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Drug Synergism; Female; Floxuridine; Fluorouracil; Gene Expression Regulation, Enzymologic; Histone Deacetylase Inhibitors; Hydroxamic Acids; Mice; Mice, Inbred BALB C; Thymidine Phosphorylase; Thymidylate Synthase; Up-Regulation; Vorinostat; Xenograft Model Antitumor Assays | 2010 |
Genome-wide mRNA and microRNA profiling of the NCI 60 cell-line screen and comparison of FdUMP[10] with fluorouracil, floxuridine, and topoisomerase 1 poisons.
Topics: Camptothecin; Cell Line, Tumor; DNA Damage; DNA Repair; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Endocytosis; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genome, Human; Humans; Irinotecan; MicroRNAs; National Cancer Institute (U.S.); Nucleosides; RNA, Messenger; Topoisomerase I Inhibitors; Topotecan; United States | 2010 |
Selective intra-arterial chemotherapy with floxuridine as second- or third-line approach in patients with unresectable colorectal liver metastases.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cohort Studies; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Follow-Up Studies; Hepatic Artery; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Organoplatinum Compounds; Oxaliplatin; Prospective Studies; Retrospective Studies; Survival Rate; Treatment Outcome | 2011 |
The achievement of mass balance by simultaneous quantification of floxuridine prodrug, floxuridine, 5-fluorouracil, 5-dihydrouracil, α-fluoro-β-ureidopropionate, α-fluoro-β-alanine using LC-MS.
Topics: Analysis of Variance; Antimetabolites, Antineoplastic; beta-Alanine; Cell Extracts; Cell Line, Tumor; Chromatography, High Pressure Liquid; Floxuridine; Fluorouracil; Humans; Linear Models; Mass Spectrometry; Reproducibility of Results; Uracil; Urea | 2011 |
Poly(ADP-Ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Benzimidazoles; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Checkpoint Kinase 1; Checkpoint Kinase 2; DNA Repair; DNA-Binding Proteins; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Female; Floxuridine; Fluorouracil; Humans; Ovarian Neoplasms; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Protein Kinases; Protein Serine-Threonine Kinases; RNA, Small Interfering; Transfection; Tumor Suppressor Proteins; X-ray Repair Cross Complementing Protein 1 | 2011 |
UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.
Topics: Animals; Cell Cycle; Cell Line, Tumor; DNA; DNA Damage; DNA Repair; Endodeoxyribonucleases; Floxuridine; Fluorouracil; Gene Knockdown Techniques; Humans; Mice; MutS Homolog 2 Protein; RNA; Thymidine; Thymine DNA Glycosylase; Uracil-DNA Glycosidase; Uridine | 2011 |
[Improved sensitivity of gastric carcinoma cells to fluorouracil-related drugs by transfection of thymidine phosphorylase gene].
Topics: Antimetabolites, Antineoplastic; Capecitabine; Cell Line, Tumor; Deoxycytidine; Floxuridine; Fluorouracil; Humans; Plasmids; Recombinant Proteins; RNA, Messenger; Sensitivity and Specificity; Stomach Neoplasms; Thymidine Phosphorylase; Transfection | 2011 |
Postoperative intraperitoneal 5-fluoro-2'-deoxyuridine added to chemoradiation in patients curatively resected (R0) for locally advanced gastric and gastroesophageal junction adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Combined Modality Therapy; Esophagogastric Junction; Feasibility Studies; Female; Floxuridine; Fluorouracil; Follow-Up Studies; Gastrectomy; Humans; Leucovorin; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Pilot Projects; Postoperative Period; Prognosis; Radiotherapy Dosage; Stomach Neoplasms; Survival Rate | 2012 |
Cellular response to efficient dUTPase RNAi silencing in stable HeLa cell lines perturbs expression levels of genes involved in thymidylate metabolism.
Topics: Floxuridine; Fluorouracil; Gene Expression Regulation; HeLa Cells; Humans; Nucleoside-Phosphate Kinase; Pyrophosphatases; RNA Interference; Thymidine Kinase | 2011 |
Inhibition of EGFR phosphorylation in a panel of human breast cancer cells correlates with synergistic interactions between gefitinib and 5'-DFUR, the bioactive metabolite of Xeloda.
Topics: Antineoplastic Agents; Breast Neoplasms; Capecitabine; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deoxycytidine; Drug Synergism; ErbB Receptors; Female; Floxuridine; Fluorouracil; Gefitinib; Gene Expression Regulation, Enzymologic; Humans; Inhibitory Concentration 50; Methotrexate; Phosphorylation; Protein Processing, Post-Translational; Quinazolines; Thymidine Phosphorylase; Thymidylate Synthase | 2012 |
Reliability of tumor primary cultures as a model for drug response prediction: expression profiles comparison of tissues versus primary cultures from colorectal cancer patients.
Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Cisplatin; Colorectal Neoplasms; Deoxycytidine; Down-Regulation; Doxorubicin; Etoposide; Floxuridine; Fluorescent Antibody Technique; Fluorouracil; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genomic Instability; Humans; Irinotecan; Metaphase; Paclitaxel; Polymerase Chain Reaction; Predictive Value of Tests; Protein Array Analysis; Reproducibility of Results; Tegafur; Tissue Array Analysis; Tumor Cells, Cultured; Up-Regulation; Uracil | 2012 |
Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil.
Topics: Ataxia Telangiectasia Mutated Proteins; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; DNA Mismatch Repair; DNA Repair; DNA-Binding Proteins; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Floxuridine; Fluorouracil; Humans; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Protein Serine-Threonine Kinases; Signal Transduction; Small Molecule Libraries; Tumor Suppressor Proteins; X-ray Repair Cross Complementing Protein 1 | 2011 |
The effect of chemotherapy or radiotherapy on thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in cancer of the uterine cervix.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Capecitabine; Carcinoma, Squamous Cell; Chemoradiotherapy; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Female; Floxuridine; Fluorouracil; Humans; Ifosfamide; Middle Aged; Neoadjuvant Therapy; Organoplatinum Compounds; Peplomycin; Thymidine Phosphorylase; Uterine Cervical Neoplasms | 2012 |
A thymidylate synthase ternary complex-specific antibody, FTS, permits functional monitoring of fluoropyrimidines dosing.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Monitoring; Female; Floxuridine; Fluorouracil; Immunoenzyme Techniques; Methotrexate; Mice; Mice, Nude; Pancreatic Neoplasms; Rats; Thymidylate Synthase; Transplantation, Heterologous; Tumor Cells, Cultured | 2012 |
Aquaporin 3 (AQP3) participates in the cytotoxic response to nucleoside-derived drugs.
Topics: Antineoplastic Agents; Apoptosis; Aquaporin 3; Blotting, Western; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Size; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Deoxycytidine; Dose-Response Relationship, Drug; fas Receptor; Floxuridine; Fluorouracil; Gemcitabine; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; MCF-7 Cells; Nucleosides; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Up-Regulation | 2012 |
Predictive markers of capecitabine sensitivity identified from the expression profile of pyrimidine nucleoside-metabolizing enzymes.
Topics: Animals; Antimetabolites, Antineoplastic; Capecitabine; Cell Line, Tumor; Cytidine Deaminase; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Floxuridine; Fluorouracil; Mice; Mice, Nude; Neoplasms; Nucleoside-Phosphate Kinase; Orotate Phosphoribosyltransferase; Ribonucleotide Reductases; RNA, Messenger; Thymidine Kinase; Thymidine Phosphorylase; Thymidylate Synthase; Uridine Kinase; Uridine Phosphorylase | 2013 |
Pharmacokinetic analysis of doxifluridine and its metabolites, 5-fluorouracil and 5-fluorouridine, after oral administration in beagle dogs.
Topics: Administration, Oral; Algorithms; Animals; Antimetabolites, Antineoplastic; Area Under Curve; Capsules; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Dogs; Floxuridine; Fluorouracil; Indicators and Reagents; Mass Spectrometry; Tandem Mass Spectrometry; Uridine | 2013 |
CD49f(high) cells retain sphere-forming and tumor-initiating activities in human gastric tumors.
Topics: Animals; Antineoplastic Agents; Biomarkers, Tumor; Doxorubicin; Drug Resistance, Neoplasm; Floxuridine; Fluorouracil; Humans; Inhibitory Concentration 50; Integrin alpha6; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Neoplasm Transplantation; Neoplastic Stem Cells; Spheroids, Cellular; Stomach Neoplasms; Tumor Cells, Cultured | 2013 |
Protein-bound polysaccharide-K augments the anticancer effect of fluoropyrimidine derivatives possibly by lowering dihydropyrimidine dehydrogenase expression in gastrointestinal cancers.
Topics: Antineoplastic Agents; Cell Proliferation; Colonic Neoplasms; Dihydrouracil Dehydrogenase (NADP); Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Leukocytes, Mononuclear; Polysaccharides; Protein Binding; Thymidylate Synthase | 2013 |
Comparative in vitro evaluation of transportability and toxicity of capecitabine and its metabolites in cells derived from normal human kidney and renal cancers.
Topics: Antimetabolites, Antineoplastic; Biological Transport; Biotransformation; Capecitabine; Cell Line, Tumor; Deoxycytidine; Equilibrative Nucleoside Transporter 1; Equilibrative-Nucleoside Transporter 2; Floxuridine; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Hydrogen-Ion Concentration; Interferon-alpha; Kidney Tubules, Proximal; Kinetics; Nucleosides; Signal Transduction; Thymidine Phosphorylase | 2013 |
[Enhanced anticancer effects of 5'-DFUR on colorectal cancer cell lines SW480 and LOVO by transfection with thymidine phosphorylase cDNA].
Topics: Cell Line, Tumor; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; Thymidine Phosphorylase; Transcription, Genetic; Transfection | 2013 |
Impact of co-administered drugs on drug monitoring of capecitabine in patients with advanced colorectal cancer.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Deoxycytidine; Drug Administration Schedule; Drug Interactions; Drug Monitoring; Floxuridine; Fluorouracil; Humans; Pantoprazole; Proton Pump Inhibitors | 2014 |
Clinical pharmacokinetics of capecitabine and its metabolites in combination with the monoclonal antibody bevacizumab.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged | 2014 |
Development of an LC-MS/MS assay for the quantitative determination of the intracellular 5-fluorouracil nucleotides responsible for the anticancer effect of 5-fluorouracil.
Topics: Antineoplastic Agents; Biological Transport; Biotransformation; Calibration; Chromatography, Liquid; Deoxyuracil Nucleotides; Drug Monitoring; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Leukocytes, Mononuclear; Linear Models; Reference Standards; Reproducibility of Results; Tandem Mass Spectrometry; Uridine Triphosphate | 2015 |
[Transfection of thymidine phosphorylase cDNA with lentiviral vector enhances the anticancer effect of 5'-deoxy-5-fluorouridine on colorectal cancer cell lines HT29 and LS174T].
Topics: Antineoplastic Agents; Cell Line; Cell Line, Tumor; Colorectal Neoplasms; DNA, Complementary; Floxuridine; Fluorouracil; Genetic Vectors; HT29 Cells; Humans; RNA, Messenger; Thymidine Phosphorylase; Transfection | 2015 |
Unresectable intrahepatic cholangiocarcinoma: Systemic plus hepatic arterial infusion chemotherapy is associated with longer survival in comparison with systemic chemotherapy alone.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Camptothecin; Cholangiocarcinoma; Deoxycytidine; Disease-Free Survival; Female; Floxuridine; Fluorouracil; Gemcitabine; Hepatic Artery; Humans; Infusions, Intra-Arterial; Irinotecan; Male; Middle Aged; Mitomycin; Retrospective Studies; Survival Rate | 2016 |
Updated long-term survival for patients with metastatic colorectal cancer treated with liver resection followed by hepatic arterial infusion and systemic chemotherapy.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Colorectal Neoplasms; Dexamethasone; Disease-Free Survival; Female; Floxuridine; Fluorouracil; Follow-Up Studies; Hepatectomy; Humans; Infusions, Intra-Arterial; Irinotecan; Leucovorin; Liver Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Survival Rate; Young Adult | 2016 |
Glycogen Synthase Kinase 3 (GSK-3)-mediated Phosphorylation of Uracil N-Glycosylase 2 (UNG2) Facilitates the Repair of Floxuridine-induced DNA Lesions and Promotes Cell Survival.
Topics: Antimetabolites, Antineoplastic; Cell Nucleus; Cell Survival; DNA Glycosylases; DNA Repair; DNA Replication; Female; Floxuridine; Fluorouracil; Glycogen Synthase Kinase 3; Humans; Ovarian Neoplasms; Phosphorylation; Tumor Cells, Cultured | 2016 |
Zika virus infection reprograms global transcription of host cells to allow sustained infection.
Topics: Adaptive Immunity; Adenosine Triphosphate; Animals; Antiviral Agents; Cell Line, Tumor; Chlorocebus aethiops; Fibroblasts; Floxuridine; Fluorouracil; Gene Expression Profiling; Glycolysis; HEK293 Cells; Host-Pathogen Interactions; Humans; Kidney; Macrophages; Microglia; RNA; THP-1 Cells; Transcription, Genetic; Transcriptome; Vero Cells; Virus Replication; Zika Virus; Zika Virus Infection | 2017 |
Effect of nucleoside analogue antimetabolites on the structure of PEO-PPO-PEO micelles investigated by SANS.
Topics: Antimetabolites; Deoxycytidine; Floxuridine; Fluorouracil; Gemcitabine; Micelles; Neutron Diffraction; Poloxamer; Polyethylene Glycols; Propylene Glycols; Scattering, Small Angle; Transition Temperature; Water | 2017 |
Circadian variations in the pharmacokinetics of capecitabine and its metabolites in rats.
Topics: Animals; Antimetabolites, Antineoplastic; Capecitabine; Circadian Rhythm; Deoxycytidine; Floxuridine; Fluorouracil; Male; Prodrugs; Rats, Wistar | 2018 |
Drug screening assay based on the interaction of intact Keap1 and Nrf2 proteins in cancer cells.
Topics: Antimetabolites, Antineoplastic; Cell Line, Tumor; Drug Evaluation, Preclinical; Floxuridine; Fluorescence Resonance Energy Transfer; Fluorouracil; Green Fluorescent Proteins; Humans; Hydroquinones; Kelch-Like ECH-Associated Protein 1; Luminescent Proteins; NF-E2-Related Factor 2; Protein Binding; Recombinant Fusion Proteins; Red Fluorescent Protein | 2019 |
Rabeprazole intake does not affect systemic exposure to capecitabine and its metabolites, 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, and 5-fluorouracil.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Capecitabine; Cell Proliferation; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Deoxycytidine; Drug Interactions; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Prospective Studies; Proton Pump Inhibitors; Rabeprazole | 2019 |
Evolved bacterial resistance against fluoropyrimidines can lower chemotherapy impact in the
Topics: Animals; Anti-Bacterial Agents; Antimetabolites; Antimetabolites, Antineoplastic; Caenorhabditis elegans; Directed Molecular Evolution; DNA Barcoding, Taxonomic; Drug Resistance, Bacterial; Escherichia coli; Floxuridine; Fluorouracil; Gene Deletion; Pyrimidines; Sequence Analysis, RNA; Whole Genome Sequencing | 2020 |
Mechanism of acquired 5FU resistance and strategy for overcoming 5FU resistance focusing on 5FU metabolism in colon cancer cell lines.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Floxuridine; Fluorouracil; Humans; Hydroxyurea; Metabolic Networks and Pathways; Pyrrolidines; Ribonucleotide Reductases; Thymidine Phosphorylase; Thymine; Trifluridine | 2021 |
Inhibition of Human Uracil DNA Glycosylase Sensitizes a Large Fraction of Colorectal Cancer Cells to 5-Fluorodeoxyuridine and Raltitrexed but Not Fluorouracil.
Topics: Antineoplastic Agents; Cell Line, Tumor; Colorectal Neoplasms; DNA Damage; Drug Screening Assays, Antitumor; Floxuridine; Fluorouracil; Humans; Quinazolines; Thiophenes; Uracil-DNA Glycosidase | 2021 |
Molecular Mechanisms and Tumor Biological Aspects of 5-Fluorouracil Resistance in HCT116 Human Colorectal Cancer Cells.
Topics: Antimetabolites, Antineoplastic; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Exome Sequencing; Floxuridine; Fluorouracil; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Irinotecan; Platinum Compounds; Thymidylate Synthase | 2021 |
DNA-Damage-Response-Targeting Mitochondria-Activated Multifunctional Prodrug Strategy for Self-Defensive Tumor Therapy.
Topics: Animals; Cell Line, Tumor; DNA; Floxuridine; Fluorouracil; Humans; Mice; Mitochondria; Prodrugs | 2022 |
Hepatic arterial infusion pump chemotherapy combined with systemic therapy for patients with advanced colorectal liver metastases: Outcomes in a newly established program.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusion Pumps; Infusions, Intra-Arterial; Liver Neoplasms | 2022 |
Predicting Dihydropyrimidine Dehydrogenase Deficiency and Related 5-Fluorouracil Toxicity: Opportunities and Challenges of
Topics: Antimetabolites, Antineoplastic; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Exons; Floxuridine; Fluorouracil; Humans | 2022 |
Effects of six pyrimidine analogs on the growth of Tetrahymena thermophila and their implications in pyrimidine metabolism.
Topics: Antimetabolites; Cytarabine; Floxuridine; Fluorouracil; Gemcitabine; Nucleosides; Pyrimidines; Tetrahymena thermophila; Thymine; Uracil | 2023 |
Growth inhibition of a human tumor cell strain by 5-fluorouracil, 5-fluorouridine, and 5-fluoro-2'-deoxyuridine; reversal studies.
Topics: Antineoplastic Agents; Deoxyuridine; Fluorouracil; Humans; Nucleosides; Nucleotides; Uridine | 1958 |
The clinical effects of the continuous administration of fluorinated pyrimidines (5-fluorouracil and 5-fluoro-2'-deoxyuridine).
Topics: Deoxyuridine; Fluorouracil; Halogenation; Neoplasms; Nucleosides; Nucleotides; Pyrimidines | 1960 |
The clinical evaluation of 5-fluorouracil and 5-fluoro-2'-deoxyuridine in solid tumors in adults: a progress report.
Topics: Antineoplastic Agents; Deoxyuridine; Fluorouracil; Neoplasms; Nucleosides; Nucleotides; Research Report; Uracil | 1960 |
Comparison of 5-fluorouracil and 5-fluoro-2'-deoxyuridine in the treatment of far-advanced breast and colon lesions.
Topics: Antineoplastic Agents; Breast Neoplasms; Colonic Neoplasms; Deoxyuridine; Fluorouracil; Humans; Nucleosides; Nucleotides; Uracil | 1962 |
Effects of uracil and thymidine on the development of resistance to 5-fluorouracil in Pediococcus cerevisiae.
Topics: Deoxyuridine; Fluorouracil; Pediococcus; Thymidine; Uracil | 1963 |
The influence of p53 status on the cytotoxicity of fluorinated pyrimidine L-nucleosides.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Deoxyuridine; Fluorouracil; Inhibitory Concentration 50; Mice; Molecular Structure; Pyrimidine Nucleosides; Tumor Suppressor Protein p53 | 2015 |
Exploring the intracellular pharmacokinetics of the 5-fluorouracil nucleotides during capecitabine treatment.
Topics: Antimetabolites, Antineoplastic; Area Under Curve; Capecitabine; Chromatography, Liquid; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Deoxyuracil Nucleotides; Deoxyuridine; Fluorouracil; Humans; Leukocytes, Mononuclear; Neoplasms; Tandem Mass Spectrometry; Uridine Triphosphate | 2016 |
LC-MS/MS assay for the quantitation of FdCyd and its metabolites FdUrd and FU in human plasma.
Topics: Biological Assay; Chromatography, Liquid; Deoxyuridine; Fluorouracil; Humans; Plasma; Tandem Mass Spectrometry; Tetrahydrouridine | 2016 |
Bacterial Metabolism Affects the C. elegans Response to Cancer Chemotherapeutics.
Topics: Animals; Antineoplastic Agents; Caenorhabditis elegans; Camptothecin; Colorectal Neoplasms; Comamonas; Deoxyuridine; Diet; Escherichia coli; Fluorouracil; Gastrointestinal Microbiome; Humans; Models, Animal; Pyrimidine Nucleosides | 2017 |
DNA-based nanoscaffolds as vehicles for 5-fluoro-2'-deoxyuridine oligomers in colorectal cancer therapy.
Topics: Cell Line, Tumor; Cholesterol; Colorectal Neoplasms; Deoxyuridine; DNA; Drug Resistance, Neoplasm; Fluorouracil; Humans; Nanostructures | 2018 |
A simple and efficient sequential electrokinetic and hydrodynamic injections in micellar electrokinetic chromatography method for quantification of anticancer drug 5-fluorouracil and its metabolite in human plasma.
Topics: Antineoplastic Agents; Chromatography, Micellar Electrokinetic Capillary; Deoxyuridine; Fluorouracil; Humans | 2021 |
Parallel G-quadruplex Structures Increase Cellular Uptake and Cytotoxicity of 5-Fluoro-2'-deoxyuridine Oligomers in 5-Fluorouracil Resistant Cells.
Topics: Cytotoxins; Deoxyuridine; Drug Resistance, Neoplasm; Fluorouracil; G-Quadruplexes; HeLa Cells; HT29 Cells; Humans; Neoplasms | 2021 |
Novel ProTide prodrugs of 5-fluoro-2'-deoxyuridine for the treatment of liver cancer.
Topics: Deoxyuridine; Fluorouracil; Humans; Liver Neoplasms; Prodrugs | 2023 |