fluorouracil has been researched along with doxifluridine in 243 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 62 (25.51) | 18.7374 |
| 1990's | 65 (26.75) | 18.2507 |
| 2000's | 87 (35.80) | 29.6817 |
| 2010's | 28 (11.52) | 24.3611 |
| 2020's | 1 (0.41) | 2.80 |
| Authors | Studies |
|---|---|
| Ajmera, S; Bapat, AR; Danenberg, PV; Stephanian, E | 1 |
| Ajmera, S; Danenberg, PV | 1 |
| Kim, SH; Rosowsky, A; Trites, D; Wick, M | 1 |
| Azuma, A; Hanaoka, K; Kobayashi, T; Matsuda, A; Minakawa, N; Nakajima, Y; Nishizono, N; Sasaki, T; Suzuki, M; Tanaka, M | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Araya, S; Fukumoto, M; Hayashi, H; Kawabata, K; Kimura, H; Masai, Y; Meyer, C; Nio, Y; Tseng, CC; Tsubono, M | 1 |
| Bajetta, E; Colleoni, M; de Braud, F; Nelli, P; Nolè, F; Zilembo, N | 1 |
| Cloos, J; Noordhuis, P; Peters, GJ; Pinedo, HM; Smid, K; van der Wilt, CL | 1 |
| Senderoff, RI; Smith, DR; Sokoloski, TD; Weber, PA | 1 |
| de Bruijn, EA; Geng, Y; Gheuens, E | 1 |
| Fukuda, S; Iwasaki, Y; Kawai, Y; Miyamoto, H; Nozue, M; Todoroki, T; Ueda, H | 1 |
| Maeda, H; Miyamoto, T; Mochinaga, N; Tsunoda, T | 1 |
| Adachi, S; Akaza, H; Ishitsuka, H; Kanazawa, K; Miwa, M; Nitta, K; Sekiguchi, F; Tokita, H | 1 |
| Akebi, N; Josen, T; Kobashi, K; Matsumura, Y; Nanba, K; Nasu, Y; Ochi, J; Ohmori, H; Saika, T; Tanahashi, T | 1 |
| Hasegawa, K; Ikeda, M; Kinugasa, M; Kobashi, Y; Noda, K; Odagiri, H; Ohiwa, T; Sekiba, K; Takeuchi, K; Watanabe, Y | 1 |
| Akazai, Y; Fuchimoto, S; Iwagaki, H; Matsubara, N; Orita, K; Shiiki, S; Watanabe, T | 1 |
| Bishop, JF; Guentert, TW; Hill, HS; Hillcoat, BL; Morris, RG; Olver, IN; Reece, PA | 1 |
| Griffiths, JR; Maxwell, RJ; Prior, MJ | 1 |
| Eda, H; Fujimoto, K; Ishida, M; Ishitsuka, H; Miwa, M; Ninomiya, Y; Sahara, H; Umeda, I; Yokose, K | 1 |
| Harada, T; Hirano, M; Kikkawa, H; Masuda, S; Matsu, T; Saito, H; Sakatoku, M; Tatsuzawa, T | 1 |
| Imai, S; Morimoto, H; Nio, Y; Shiraishi, T; Tobe, T; Tseng, CC; Tsubono, M | 1 |
| De Clercq, E; Iigo, M; Miwa, M | 1 |
| Aikawa, T; Hirai, T; Kaji, M; Kitada, M; Kotsuma, Y; Maeura, Y; Miyauchi, K; Satomi, T; Takatsuka, Y; Yayoi, E | 1 |
| Izumi, T; Kumagai, K; Kurihara, M; Masuo, K; Nishida, Y; Sanada, Y; Yasui, A | 1 |
| Inaba, M; Mitsuhashi, J; Ozawa, S | 1 |
| Adachi, I; Douden, K; Hayashi, H; Hikishima, H; Iwa, T; Munemoto, Y; Okada, Y; Omura, K; Watanabe, Y | 1 |
| Fukushima, T; Hara, Y; Hashimoto, T; Hirakawa, T; Kono, A; Tanaka, M; Tomonaga, M; Yamashita, M | 1 |
| Laurensse, E; Leyva, A; Peters, GJ; Pinedo, HM | 1 |
| Armstrong, RD; Cadman, EC; Takimoto, CH; Tan, YY | 1 |
| Ando, J; Kosaka, A; Sumiyoshi, K | 1 |
| Braakhuis, BJ; de Bruijn, EA; Laurensse, EJ; Peters, GJ; Pinedo, HM; van Walsum, M | 1 |
| Araki, E; Hoshi, A; Iigo, M; Nakajima, Y | 1 |
| Baba, T; Furukohri, N; Itoh, T; Munakata, A; Ogasawara, H; Saitoh, S; Sakata, Y; Tamura, Y; Tsushima, K; Yoshida, Y | 1 |
| De Clercq, E; Hoshi, A; Iigo, M; Nakajima, Y; Nishikata, K; Odagiri, H; Okudaira, N | 1 |
| Ishikawa, T; Ishitsuka, H; Ohkawa, T; Tanaka, Y | 1 |
| Braakhuis, BJ; Laurensse, EJ; Peters, GJ; Pinedo, HM | 1 |
| Endoh, F; Fujimoto, S; Igarashi, K; Kawata, S; Miyazaki, M; Ohta, M; Shimura, T; Shrestha, RD; Sugasawa, H; Takahashi, O | 1 |
| de Bruijn, EA; Pinedo, HM; Reeuwijk, HJ; Tjaden, UR; van Oosterom, AT | 1 |
| Edwards, IR; Ferry, DG; Hung, CT; Perrier, DG; Schaaf, LJ | 1 |
| Baba, H; Kunimoto, T; Nitta, K; Sasaki, T; Takeuchi, M; Tanaka, T; Uehara, N | 1 |
| Armand, JP; Bernadou, J; Béteille, JP; Bon, M; Lopez, A; Malet-Martino, MC; Martino, R | 1 |
| Armstrong, RD; Cadman, EC; Takimoto, CH | 1 |
| Endoh, F; Fujimoto, S; Igarashi, K; Miyazaki, M; Ohta, M; Okui, K; Shrestha, RD; Togawa, Y | 1 |
| Faure, F; Hollande, E; Malet-Martino, MC; Martino, R; Palevody, C; Vialaneix, JP | 1 |
| Lankelma, J; Laurensse, EJ; Leyva, A; Peters, GJ; Pinedo, HM; van Dijk, J; van Groeningen, C | 1 |
| Fosså, SD; Heier, MS; Heintz, R | 1 |
| Au, JL; Canobbio, L; Rustum, YM; Trave, F | 1 |
| Cook, A; Ishitsuka, H; Miwa, M | 1 |
| Fujita, F; Fujita, M; Inaba, H; Sakamoto, Y; Shimozuma, K; Taguchi, T | 1 |
| Taguchi, T | 2 |
| Berg-Johnsen, J; Heier, MS; Langmoen, IA | 1 |
| Ishitsuka, H; Kamiyama, T; Miwa, M; Nishimura, J | 1 |
| Eda, H; Fujimoto, K; Fukuda, H; Ishitsuka, H; Miwa, M | 1 |
| Alberto, P; Cavalli, F; Germano, G; Joss, R; Kaplan, S; Martz, G; Mermillod, B; Spati, B; Weber, W | 1 |
| Alley, PA; Choong, YS; Lee, SP | 1 |
| Ichihara, S; Kuruma, I; Odagiri, H; Semura, E; Tateishi, M; Utoh, M | 1 |
| Almersjö, O; Berne, M; Gustavsson, B; Spears, P; Sundström, E | 1 |
| Dobbs, BR; Edwards, IR; Perrier, DG; Schaaf, LJ | 2 |
| Hattori, T; Hirabayashi, N; Kirihara, Y; Niimoto, M; Nishiyama, M; Nosoh, Y; Saeki, T; Takagami, S | 1 |
| Bernheim, JL; De Dobbeleer, GB; Roobol, C | 1 |
| Hoshi, A; Iigo, M; Nishimura, S; Yamaizumi, Z | 1 |
| Aoyama, A; Hirata, K; Niitani, H; Ootsuka, M; Shibuya, M; Shimabukuro, Z; Yano, T | 1 |
| Choong, YS; Lee, SP | 1 |
| Au, JL; Luccioni, CM; Rustum, YM; Wientjes, MG | 1 |
| Cadman, E; Grant, S | 1 |
| Aubert, C; Cano, JP; Coassolo, P; Rigault, JP; Sommadossi, JP | 1 |
| Carter, GL; Cory, JG | 1 |
| Isobe, K; Iwase, H; Kimura, K; Kuwabara, T; Sato, A; Suga, S; Takada, T; Yokoyama, Y; Yoshida, Y | 1 |
| Au, JL; Minowada, J; Rustum, YM; Srivastava, BI | 1 |
| Armstrong, RD; Cadman, E | 1 |
| Armstrong, RD; Connolly, KM; Diasio, RB; Kaplan, AM | 1 |
| Kimura, K; Suga, S | 1 |
| Almersjö, O; Berne, M; Gastavsson, B; Waldenström, J | 1 |
| Bollag, W; Hartmann, HR | 1 |
| Imai, S; Nakazawa, M; Tamatsu, H; Watari, H | 1 |
| Hara, Y | 1 |
| Hara, Y; Kono, A; Tanaka, M | 1 |
| Fujii, S; Shirasaka, T | 1 |
| Cooper, AJ; Goeting, N; Morgan, GR; Taylor, I; Trotter, GA | 1 |
| Armstrong, RD; Diasio, RB | 1 |
| Fukuoka, K; Ishitsuka, H; Itoga, A; Maruyama, HB; Miwa, M; Takemoto, K | 1 |
| Ishitsuka, H; Kitta, K; Ohta, Y; Sueki, K; Takemoto, K; Yagi, Y | 1 |
| Fukazawa, H; Hongu, Y; Ichihara, S; Shimizu, H; Suzuki, S | 1 |
| Bicknell, R; Harris, AL; Moghaddam, A; Patterson, AV; Stratford, IJ; Talbot, DC; Zhang, H | 1 |
| Akiyama, S; Furukawa, T; Haraguchi, M; Sumizawa, T | 1 |
| Aida, I; Kasuga, Y; Ohwada, M; Sato, I; Suzuki, M; Tamura, T | 1 |
| Adachi, E; Baba, H; Kounoe, S; Matsuoka, H; Miyazaki, N; Nagamine, S; Ohshiro, T; Saito, T; Seo, Y; Shiromizu, A | 1 |
| Eliason, JF; Givel, JC; Laurent, PL; Odartchenko, N; Tevaearai, HT | 1 |
| Mori, T; Takahashi, K; Takahashi, T | 1 |
| Haruta, A; Ikeda, S; Jyozaki, H; Tanaka, S; Toriya, H; Umeno, T | 1 |
| Ito, T; Komatsu, Y; Moriya, N; Ogasawara, H; Saito, S; Sakata, Y; Sugimoto, N; Tamura, Y; Tsushima, K; Yamada, Y | 2 |
| Fukushima, S; Hamada, A; Kawaguchi, T; Morinaga, A; Nakano, M; Saneyoshi, M | 1 |
| Fukagawa, H; Hirohashi, Y; Iwanaga, A; Iyama, A; Kitahara, K; Miyazaki, K; Mori, M; Sasatomi, E; Tsutsumi, N; Yakushiji, H | 1 |
| Kumagai, K; Masuo, K; Nishida, Y; Yasui, A; Yoshitoshi, A | 1 |
| Hanyu, F; Hayashi, T; Igarashi, T; Suzuki, M; Watanabe, K; Yoshida, K | 1 |
| el Kouni, MH; el Kouni, MM; Naguib, FN | 1 |
| Eda, H; Fujimoto, K; Hino, A; Ishitsuka, H; Tanaka, Y; Ura, M; Wada, K; Watanabe, S | 1 |
| Barbour, KW; Berger, FG; Berger, SH; Hughey, CT | 1 |
| De Lena, M; Guerrieri, A; Lorusso, V; Palmisano, F; Zambonin, PG | 1 |
| Amadori, D; Bajetta, E; Calabresi, F; Colleoni, M; Comella, G; Lorusso, V; Marangolo, M; Rosso, R; Scanni, A; Sobrero, A | 1 |
| Eda, H; Fujimoto, K; Ishikawa, T; Ishitsuka, H; Ohiwa, T; Tanaka, Y; Tatsuno, K; Watanabe, S | 1 |
| Fukushima, S; Hamada, A; Kawaguchi, T; Nakano, M; Saneyoshi, M; Shimizu, S | 1 |
| Furukawa, J; Kinuta, M; Maruhashi, S; Maruyama, H; Masuda, N; Matsui, S; Okamura, J; Ooi, H; Takiguchi, S; Tateishi, H; Tokunaga, M; Yano, H; Yayoi, E | 1 |
| Hino, A; Ishitsuka, H; Matsumoto, T; Mori, K; Nishida, M; Yoshikubo, T | 1 |
| Baba, H; Kohnoe, S; Matsuoka, H; Morita, M; Saito, T; Seo, Y; Taketomi, A; Tomoda, H | 1 |
| Artale, S; Bajetta, E; Bignami, P; Buzzoni, R; Del Vecchio, M; Di Bartolomeo, M; Magnani, E; Somma, L; Zunino, F | 1 |
| Fukase, Y; Ishikawa, T; Ishitsuka, H; Sawada, N; Sekiguchi, F | 1 |
| Shin, E; Takatsuka, Y | 1 |
| Nakagawa, T; Sawai, Y; Yamaoka, K | 1 |
| Fukase, Y; Ishikawa, T; Ishitsuka, H; Sekiguchi, F; Yamamoto, T | 1 |
| Bajetta, E; Biganzoli, L; Buzzoni, R; Carnaghi, C; Cassata, A; Di Bartolomeo, M; Galante, E; Mariani, L; Spagnoli, I; Stampino, CG | 1 |
| Fujita, K; Hirano, Y; Suzuki, K; Takayama, T; Ushiyama, T | 1 |
| Ishikawa, T; Ishitsuka, H; Miwa, M; Mori, K; Nishida, M; Sawada, N; Shimma, N; Umeda, I; Ura, M | 1 |
| Fujitake, S; Kataoka, S; Maeda, Y; Nozaki, H; Shimizu, M; Tohyama, M | 2 |
| Cano, JP; Cuq, P; Evrard, A; Pèlegrin, A; Robert, B; Vian, L | 1 |
| Tominaga, T | 1 |
| González Barón, M | 1 |
| Hoshino, K; Ikeda, H; Koyama, T; Morishita, Y; Nakamura, M | 1 |
| Endo, M; Fukase, Y; Ishikawa, T; Ishitsuka, H; Sawada, N; Shinbori, N; Tanaka, Y | 1 |
| Cano, JP; Ciccolini, J; Cuq, P; Evrard, A; Vian, L | 1 |
| Basaki, Y; Chikahisa, L; Hashimoto, A; Miyadera, K; Okabe, S; Wierzba, K; Yamada, Y; Yonekura, K | 1 |
| Fukushima, H; Goya, T; Hanaoka, T; Matsuda, M; Sato, K; Tanaka, R | 1 |
| Adenis, A; Conroy, T; Paillot, B | 1 |
| Musha, N; Oka, K; Saito, H; Sando, N; Sasaki, M; Setu, M; Setu, Y; Sunami, E | 1 |
| Hohya, I; Idezuki, Y; Ishida, H; Nakada, H; Suzuki, T; Takeuchi, I; Yamada, H | 1 |
| Amano, M; Haba, A; Monden, M; Monden, T; Ohue, M; Sakita, I; Sekimoto, M; Tamaki, Y; Tomita, N | 1 |
| Fujimoto, S; Nakajima, N; Nakazato, H; Saitoh, N; Takiguchi, N | 1 |
| Gen, T; Hara, Y; Igarashi, K; Jibiki, M; Kawasaki, T; Kikuchi, M; Kudoh, A; Noguchi, N; Yabata, E | 1 |
| Hirakawa, Y; Kawaguchi, Y; Kuwata, K; Matsushima, E; Nagayama, S | 1 |
| Au, JL | 1 |
| Akasaka, Y; Hata, Y; Nakanishi, Y; Ogita, M; Sasaki, F; Sawada, Y; Takahashi, H; Uchino, J; Yoshimoto, M | 1 |
| Kim, NK; Min, JS; Noh, JK; Park, JK; Yun, SH | 1 |
| Furukawa, J; Hashimoto, T; Katsumoto, Y; Nakaguchi, K; Okajima, S; Shingai, T; Sue, F; Takekuni, K; Teshima, S; Yoshioka, S; Yukawa, M | 1 |
| Fujii, M; Kaiga, T; Ueda, T; Watanabe, Y | 1 |
| Ino, H; Kanaya, Y; Kawasaki, K; Maruyama, S; Okumoto, T; Otani, J; Soda, M; Yokoyama, N | 1 |
| Fukuda, Y; Hirao, S; Kinoshita, H; Koyama, I; Mayumi, K; Takatori, H; Terakura, M; Tsukazaki, Y | 1 |
| Jung, HC; Kim, NK; Min, JS; Park, JK; Roh, JK; Sung, JS; Yun, SH | 1 |
| Matsuzaki, A; Morita, T; Tokue, A | 1 |
| Fujimoto-Ouchi, K; Tanaka, Y; Tominaga, T | 1 |
| Casado, FJ; Fernández-Veledo, S; García-Manteiga, JM; Guillén-Gómez, E; Larrayoz, IM; Lloberas, J; Lostao, MP; Mata, JF; Pastor-Anglada, M | 1 |
| Chazal, M; Dubreuil, A; Etienne, MC; Fischel, JL; Marchetti, S; Milano, G | 1 |
| Kato, S; Onda, M; Tanaka, N; Tanaka-Nozaki, M | 1 |
| Ishii, R; Koda, K; Miyazaki, M; Oda, K; Takiguchi, N | 1 |
| Eriguchi, M; Matsuzawa, A; Nonaka, Y; Takeda, Y; Yanagie, H; Yoshizaki, I | 1 |
| Fujioka, M; Hashimoto, D; Hoshino, T; Inokuma, S; Ishida, H; Ishizuka, N; Matsumoto, Y; Miura, T; Murata, N; Nakada, H; Odaka, A; Ohsawa, T; Takeuchi, I; Yamada, H; Yokoyama, M | 1 |
| Higashigawa, M; Kagawa, Y; Kakito, H; Kawasaki, H; Kojima, M; Ohkubo, T; Ooi, A; Sakurai, M | 1 |
| Baldwin, SA; Cass, CE; Clarke, ML; Coupland, RW; Dabbagh, L; Jennings, LL; Koski, SL; Mackey, JR; Santos, CL; Vsianska, M; Young, JD | 1 |
| Aoyagi, K; Basaki, Y; Chikahisa, L; Hashimoto, A; Miyadera, K; Okabe, S; Wierzba, K; Yamada, Y; Yonekura, K | 1 |
| Iwahashi, M; Nagata, T; Nakamori, M; Yamaue, H | 1 |
| Andreola, S; Baratti, D; Bozzetti, F; Mariani, L; Spinelli, P; Stani, SC; Valvo, F | 1 |
| Fujita, K; Hirano, Y; Kageyama, S; Suzuki, K; Takayama, T; Ushiyama, T | 1 |
| Asaumi, Y; Hara, T; Hirano, M; Kikkawa, H; Kikuchi, T; Murakami, N; Nozawa, H; Takizawa, M; Uno, Y | 1 |
| Azuma, T; Hatada, T; Inoue, Y; Kusunoki, M; Miki, C; Mohri, T; Ojima, E | 1 |
| Fukuoka, M; Hamada, M; Kaniwa, N; Matsumoto, Y; Murayama, N; Nakajima, Y; Ohno, Y; Ozawa, S; Sawada, J | 1 |
| Brunner, M; Eichler, HG; Locker, G; Mader, RM; Mueller, M; Rizovski, B; Schrolnberger, C; Steger, GG; Wenzel, C | 1 |
| Ahn, JH; Kang, YK; Kim, JC; Kim, JG; Kim, TW; Kim, WK; Lee, JH; Lee, JS; Min, YJ; Yu, CS | 1 |
| Konishi, H; Minouchi, T; Morita, K; Sato, T; Yamaji, A; Yoshimoto, T | 1 |
| Blesch, KS; Burger, HU; Gieschke, R; Reigner, B; Steimer, JL | 1 |
| Machida, Y; Nagai, T; Onishi, H; Yoshino, T | 1 |
| Koda, K; Kodaira, S; Miyazaki, M; Nakazato, H; Ogawa, K; Saito, N; Sarashina, H; Suwa, T; Suzuki, M; Watanabe, S | 1 |
| Miwa, K; Nishimura, G | 1 |
| Ciccolini, J; Dubreuil, A; Etienne, MC; Fischel, JL; Formento, JL; Formento, P; Magné, N; Marchetti, S; Milano, G; Renée, N; Tiffon, C | 1 |
| Handa, R; Iijima, S; Kato, T; Kikkawa, N; Kurokawa, E; Naoi, Y; Oshima, S; Tsujie, M; Yamamoto, H | 1 |
| Heerschap, A; Kamm, YJ; Klomp, DW; Punt, CJ; van Laarhoven, HW | 1 |
| Chiba, K; Hosakawa, M; Katoh, M; Nakajima, M; Tabata, T; Tokudome, S; Yokoi, T | 1 |
| Ajani, JA; Itoh, N; Itoi, H; Shirasaka, T; Ueda, Y; Yamagishi, H; Yamashita, T | 1 |
| Ding, Q; Li, G; Wen, DG; Yan, CY; Zhang, YF | 1 |
| Cao, D; Pizzorno, G | 1 |
| Ciccolini, J; Etienne-Grimaldi, MC; Fischel, JL; Formento, P; Milano, G | 1 |
| Hiro, J; Inoue, Y; Kobayashi, M; Kusunoki, M; Miki, C; Mori, K; Shirane, M; Tanaka, K; Yanagi, H | 1 |
| Hazama, S; Mori, N; Oka, M; Tamesa, T; Tangoku, A; Watanabe, Y; Yamamoto, S; Yoshimura, K | 1 |
| Harada, H; Imaizumi, H; Kosaka, T; Kuroda, M; Takashima, S; Tanaka, Y; Yokoi, M; Yoshitani, S | 1 |
| Fujitani, K; Hirao, M; Ikenaga, M; Kashiwazaki, M; Masuda, N; Mishima, H; Sawamura, T; Takeda, Y; Takeno, A; Tsujinaka, T | 1 |
| Baba, H; Emi, Y; Ishida, T; Kakeji, Y; Maehara, Y | 1 |
| Ikemoto, S; Kuratsukuri, K; Nakatani, T; Sugimura, K; Wada, S; Yoshida, N | 1 |
| Hashiguchi, H; Hirooka, Y; Kamasako, A; Nozaka, K; Ohgami, Y; Otani, S; Takebayashi, M; Tanida, O; Toyota, N; Wakatsuki, T | 1 |
| Akimoto, T; Hasegawa, K; Kishimoto, Y; Morimoto, Y; Sawai, T | 1 |
| Hasegawa, R; Hasegawa, S; Koda, K; Miyazaki, M; Oda, K; Seike, K; Takiguchi, N | 1 |
| Ebi, H; Igarashi, T; Kawada, K; Minami, H; Saeki, T; Sasaki, Y; Sigeoka, Y; Ueda, R; Usubuchi, N | 1 |
| Dantzig, AH; Johnston, PA; Kandasamy, RA; Perry, W; Pratt, S; Shepard, RL | 1 |
| Hayakawa, K; Miyake, K; Morimoto, T; Mukaihara, S; Nishino, M | 1 |
| Fujioka, A; Fukushima, M; Ikeda, K; Kitazato, K; Nakagawa, F; Ohshimo, H; Okabe, H; Takechi, T | 1 |
| Wang, HD; Zheng, JF | 1 |
| Fujimoto-Ouchi, K; Hata, K; Hiraga, T; Ikeda, F; Kitagaki, J; Tanaka, Y; Yoneda, T | 1 |
| Hamada, K; Kakihara, Y; Kubota, K; Mori, S; Nakagawa, A; Suzuki, N; Tachibana, M; Tagaya, N | 1 |
| Guichard, SM; Jodrell, DI; Mayer, I | 1 |
| Hamada, T; Ichimura, W; Minagawa, N; Mino, K; Naito, H; Orimo, T; Shibazaki, W; Shinohara, T | 1 |
| Lokiec, F; Rezaí, K; Urien, S | 1 |
| Ebi, H; Minami, H | 1 |
| Fukumitsu, T; Ishibashi, N; Matono, K; Mizobe, T; Ogata, Y; Sasatomi, T; Shirouzu, K; Torigoe, S; Yamashita, N; Yanagawa, T | 1 |
| Cao, D; Pizzorno, G; Wan, L; Yan, R; Zeng, J | 1 |
| Akiyama, S; Baba, M; Furukawa, T; Gotanda, T; Haraguchi, M; Hongye, Z; Nakagawa, M; Sumizawa, T; Tachiwada, T; Tsuneyoshi, K | 1 |
| Cao, D; Pizzorno, G; Wan, L; Yan, R | 1 |
| Cricca, S; de Bruin, M; Laan, AC; Masterson, AJ; Noordhuis, P; Peters, GJ; Temmink, OH; Turksma, AW | 1 |
| Horii, I; Kawashima, A; Kobayashi, K; Nakano, K; Shindoh, H; Shishido, N | 1 |
| Hiro, J; Inoue, Y; Kusunoki, M; Miki, C; Nakatani, K; Nobori, T; Ojima, E; Toiyama, Y; Watanabe, H | 1 |
| Hosokawa, N; Kaji, M; Kubo, M; Miyatani, K; Mizuta, M; Shirakawa, K; Suwaki, K; Toyokawa, T; Udaka, T; Yamane, M | 1 |
| Ando, H; Bykowski, C; Dhananjeyan, MR; Erhardt, PW; Liu, J; Sarver, JG; Trendel, JA | 1 |
| Peters, GJ; Prins, HJ; Temmink, OH; van Gelderop, E | 1 |
| Ebisui, C; Fujimoto, T; Fujiwara, S; Fukuchi, N; Hasuike, Y; Hayashi, N; Sakita, I; Tsujie, M; Yoshida, T | 1 |
| Amano, M; Fukunaga, M; Ikeda, K; Ikeda, M; Ikenaga, M; Ishida, H; Kato, T; Mishima, H; Monden, M; Murata, K; Ohnishi, T; Ota, H; Sakamoto, J; Sekimoto, M; Tominaga, S | 1 |
| Murakami, S; Yamamoto, Y | 1 |
| Ishizu, K; Makuuchi, H; Sadahiro, S; Sunose, N; Tsuruo, T; Yamazaki, K; Yamori, T | 1 |
| Baldwin, J; Basche, M; Britten, CD; Camidge, DR; Darstein, C; Finn, RS; Gail Eckhardt, S; Gore, L; Holden, SN; Leong, S; Musib, L; O'Bryant, CL; Thornton, D | 1 |
| Hoshino, S; Maekawa, T; Mikami, K; Sakai, T; Shirakusa, T; Yamashita, Y | 1 |
| Jeong, EJ; Kim, CY; Kim, GH; Woo, YA | 1 |
| Huh, JW; Kim, HR | 1 |
| Beijnen, JH; Rosing, H; Schellens, JH; Vainchtein, LD | 1 |
| Nakayama, T; Noguchi, S | 1 |
| Genda, T; Hori, S; Miki, A; Nakajima, M; Satoh, H; Sawada, Y; Suehira, M | 1 |
| Czejka, M; Farkouh, A; Gruenberger, B; Scheithauer, W; Schueller, J | 1 |
| Czejka, M; Farkouh, A; Scheithauer, W; Schueller, J | 1 |
| Arra, C; Avallone, A; Bruzzese, F; Budillon, A; Chianese, MI; de Ruggiero, I; Di Cintio, A; Di Gennaro, E; Franco, R; Luciano, A; Moccia, T; Piro, G | 1 |
| Gao, MQ; Huang, AM; Zhuo, LJ | 1 |
| Ait-Tihyaty, M; Jean-Claude, BJ; Mihalcioiu, C; Rachid, Z | 1 |
| Bellot, GL; Koh, D; Tan, WH; Tay, LL; Wang, X | 1 |
| Hasegawa, K; Kato, R; Kawamura, K; Kobayashi, Y; Okamoto, H; Sekiya, T; Udagawa, Y | 1 |
| Casado, FJ; Molina-Arcas, M; Pastor-Anglada, M; Pérez-Torras, S; Trigueros-Motos, L | 1 |
| Harada, N; Kurasawa, M; Mori, K; Sato, Y; Yanagisawa, M; Yasuno, H | 1 |
| Baek, IH; Kim, MS; Kwon, KI; Lee, BY | 1 |
| Baba, K; Eishi, Y; Fukamachi, H; Funasaka, C; Inokuchi, M; Jang, SJ; Kato, K; Kawachi, H; Kim, JH; Kim, MJ; Kim, WH; Kojima, K; Park, YS; Seol, HS; Shimada, S; Yook, JH; Yuasa, Y | 1 |
| Albain, KS; Blanke, CD; Coleman, D; Ely, B; Gold, PJ; Gotay, C; Lenz, HJ; Louie, SG; Raghavan, D; Shields, AF | 1 |
| Abe, H; Edamatsu, T; Fujieda, A; Fujioka, M; Mekata, E; Murata, S; Naka, S; Shimizu, T; Shiomi, H; Sonoda, H; Tani, T; Umeda, T; Wada, T; Yamamoto, H | 1 |
| Cass, CE; Damaraju, VL; Kuzma, M; Mowles, D; Sawyer, MB; Wilson, M | 1 |
| Gao, Q; Liu, J; Liu, Y; Wang, QW; Ye, DJ; Zhang, JM | 1 |
| Czejka, M; Dittrich, C; Gintersdorfer, S; Kitzmueller, M; Lichtneckert, M; Neudorfer, C; Poxhofer, M; Schreiber, V | 1 |
| Buchner, P; Czejka, M; Farkouh, A; Georgopoulos, A; Gruenberger, B; Scheithauer, W; Schueller, J | 1 |
| Chen, X; Dai, X; Deng, P; Ding, L; Ji, C; Zhong, D | 1 |
| Liu, Q; Wang, Q; Ye, D; Zhang, J | 1 |
| Baken, BC; Erlinghagen, V; Fuhr, U; Kubeš, V; Novotný, V; Peroutka, R; Queckenberg, C; Van Os, SH; Wargenau, M | 1 |
| Doki, Y; Fujita, J; Fujitani, K; Fujiwara, Y; Hirao, M; Imamura, H; Kimura, Y; Moon, JH; Mori, M; Takiguchi, S; Tamura, S; Yano, M | 1 |
| Chionh, F; Lau, D; Price, T; Tebbutt, N; Yeung, Y | 1 |
| Ito, Y; Kobuchi, S; Sakaeda, T; Yazaki, Y | 1 |
| Fujita, KI; Ishida, H; Ishikawa, F; Kubota, Y; Ohkuma, R; Sasaki, Y; Sekido, M; Shibanuma, M; Takahashi, T; Tsunoda, T | 1 |
| Beijnen, JH; Cats, A; de Vries, N; Guchelaar, HJ; Knikman, JE; Rosing, H | 1 |
13 review(s) available for fluorouracil and doxifluridine
| Article | Year |
|---|---|
[Treatment strategy for recurrent breast cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Cyclophosphamide; Doxorubicin; Epirubicin; Female; Floxuridine; Fluorouracil; Gonadotropin-Releasing Hormone; Humans; Infusions, Intravenous; Medroxyprogesterone Acetate; Neoplasm Recurrence, Local; Palliative Care; Survival Rate; Tamoxifen | 1998 |
[Gastrointestinal cancer and oral anticancer agents].
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Agents; Camptothecin; Drug Combinations; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Humans; Irinotecan; Organoplatinum Compounds; Oxonic Acid; Prodrugs; Pyridines; Tegafur; Uracil | 1999 |
[Recent development of oral anti-cancer drugs for breast cancer].
Topics: Administration, Oral; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Clinical Trials, Phase II as Topic; Cyclophosphamide; Drug Administration Schedule; Fadrozole; Female; Floxuridine; Fluorouracil; Gonadotropin-Releasing Hormone; Humans; Medroxyprogesterone Acetate; Survival Rate; Tamoxifen; Toremifene | 1999 |
[Oral fluoropyrimidines in oncology].
Topics: Administration, Oral; Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Clinical Trials as Topic; Combined Modality Therapy; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Male; Neoplasm Recurrence, Local; Neoplasms; Tegafur; Time Factors; Uracil | 1998 |
[New drugs in gastrointestinal oncology. Current status and future directions].
Topics: Antineoplastic Agents; Camptothecin; Capecitabine; Deoxycytidine; Docetaxel; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Gemcitabine; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Quinazolines; Taxoids; Tegafur; Thiophenes; Vinblastine; Vinorelbine | 1999 |
[Doxifluridine for treatment of colorectal cancer].
Topics: Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Floxuridine; Fluorouracil; Humans; Pentosyltransferases; Prodrugs; Prognosis; Pyrimidine Phosphorylases; Thymidine Phosphorylase | 2003 |
Uridine phosophorylase: an important enzyme in pyrimidine metabolism and fluoropyrimidine activation.
Topics: Animals; Antimetabolites, Antineoplastic; Floxuridine; Fluorouracil; Gene Expression Regulation, Enzymologic; Humans; Neoplasms; Pyrimidines; Uridine; Uridine Phosphorylase | 2004 |
[Effectiveness of chemoradiotherapy for three cases of squamous cell anal carcinoma].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Anus Neoplasms; Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Female; Floxuridine; Fluorouracil; Humans; Lymphatic Metastasis; Middle Aged; Radiotherapy, Adjuvant; Tegafur; Uracil | 2004 |
[Current combination chemotherapy containing paclitaxel for advanced, recurrent gastric cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Drug Combinations; Floxuridine; Fluorouracil; Humans; Oxonic Acid; Paclitaxel; Pyridines; Quality of Life; Stomach Neoplasms; Tegafur | 2004 |
Uridine phosphorylase in breast cancer: a new prognostic factor?
Topics: Animals; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Breast Neoplasms; Capecitabine; Deoxycytidine; Enzyme Induction; Female; Floxuridine; Fluorouracil; Gene Expression Regulation; Humans; Mice; Prodrugs; Prognosis; Pyrimidinones; Treatment Outcome; Uridine Phosphorylase | 2006 |
A phase II study of irinotecan in combination with doxifluridine, an intermediate form of capecitabine, in patients with metastatic colorectal cancer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Female; Floxuridine; Fluorouracil; Follow-Up Studies; Hematologic Diseases; Humans; Irinotecan; Leukocyte Count; Male; Middle Aged; Neoplasm Metastasis; Sample Size; Survival Analysis | 2008 |
Therapeutic usefulness of postoperative adjuvant chemotherapy with Tegafur-Uracil (UFT) in patients with breast cancer: focus on the results of clinical studies in Japan.
Topics: Administration, Oral; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Chemotherapy, Adjuvant; Cisplatin; Clinical Trials as Topic; Deoxycytidine; Drug Combinations; Female; Floxuridine; Fluorouracil; Humans; Japan; Methotrexate; Oxonic Acid; Tegafur; Uracil | 2010 |
Oral versus intravenous fluoropyrimidines for colorectal cancer.
Topics: Administration, Oral; Adult; Antineoplastic Agents; Camptothecin; Capecitabine; Chemotherapy, Adjuvant; Colorectal Neoplasms; Disease-Free Survival; Female; Floxuridine; Fluorouracil; Humans; Injections, Intravenous; Irinotecan; Male; Neoadjuvant Therapy; Organoplatinum Compounds; Palliative Care; Pyridines; Pyrimidines; Randomized Controlled Trials as Topic; Tegafur; Uracil | 2017 |
30 trial(s) available for fluorouracil and doxifluridine
| Article | Year |
|---|---|
A randomized comparison of doxifluridine and fluorouracil in colorectal carcinoma.
Topics: Adenocarcinoma; Antineoplastic Agents; Clinical Trials as Topic; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Random Allocation; Rectal Neoplasms | 1988 |
The pharmacokinetics of doxifluridine and 5-fluorouracil after single intravenous infusions of doxifluridine to patients with colorectal cancer.
Topics: Adult; Aged; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Half-Life; Humans; Infusions, Intravenous; Male; Middle Aged | 1988 |
[5-FU concentrations in the blood and tumor tissue after 5'-DFUR or UFT administration in the patients with uterine cervical cancer].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Female; Floxuridine; Fluorouracil; Humans; Lymph Nodes; Middle Aged; Tegafur; Uracil; Uterine Cervical Neoplasms | 1995 |
[Pharmacological study of 5'-DFUR oral administration and the clinical responses against gastrointestinal carcinoma].
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Pancreatic Neoplasms; Stomach Neoplasms; Treatment Outcome | 1995 |
[Hepatic arterial infusion after hepatectomy for liver metastases of colorectal carcinoma to prevent residual hepatic recurrence].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Hepatectomy; Hepatic Artery; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm, Residual; Prognosis | 1994 |
[A study of preoperative administration of 5'-DFUR in patients with colo-rectal cancer].
Topics: Administration, Oral; Antineoplastic Agents; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Lymph Nodes; Lymphatic Metastasis; Pentosyltransferases; Preoperative Care; Pyrimidine Phosphorylases | 1994 |
[Randomized controlled study of sequential methotrexate and 5-fluorouracil therapy with or without 5'-deoxy-5-fluorouridine against advanced gastrointestinal cancer. Hirosaki Cooperative Study Group for Cancer Chemotherapy].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Quality of Life; Survival Analysis | 1994 |
[Sequential methotrexate/5-fluorouracil therapy with 5'-deoxy-5-fluorouridine against advanced gastric cancer: comparison between bolus injection and drip infusion of 5-fluorouracil administration. Hirosaki Cooperative Study Group for Cancer Chemotherapy]
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Alopecia; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Injections, Intravenous; Leukopenia; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Stomach Neoplasms | 1994 |
Prospective randomised trial comparing fluorouracil versus doxifluridine for the treatment of advanced colorectal cancer.
Topics: Adult; Aged; Antineoplastic Agents; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Leukopenia; Male; Middle Aged; Prospective Studies | 1993 |
Doxifluridine in colorectal cancer patients resistant to 5-fluorouracil (5-FU) containing regimens.
Topics: Administration, Oral; Adult; Aged; Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Agents; Colorectal Neoplasms; Drug Resistance, Neoplasm; Drug Therapy, Combination; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Tomography, X-Ray Computed | 1997 |
Oral doxifluridine plus levoleucovorin in elderly patients with advanced breast cancer.
Topics: Administration, Oral; Aged; Aged, 80 and over; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Methotrexate; Neoplasm Staging | 1998 |
Selective augmentations of intratumoral 5-fluorouracil concentration by local immunotherapy with OK-432 and fibrinogen.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Chemotherapy, Adjuvant; Colon; Colorectal Neoplasms; Combined Modality Therapy; Drug Synergism; Female; Fibrinogen; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Neoadjuvant Therapy; Picibanil; Rectum | 2000 |
A phase III randomized study comparing oral doxifluridine and oral 5-fluorouracil after curative resection of gastric cancer.
Topics: Administration, Oral; Adult; Aged; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Stomach Neoplasms; Time Factors | 2000 |
A prospective randomized trial comparing intravenous 5-fluorouracil and oral doxifluridine as postoperative adjuvant treatment for advanced rectal cancer.
Topics: Adenocarcinoma; Administration, Oral; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Disease-Free Survival; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasm Recurrence, Local; Postoperative Period; Prospective Studies; Quality of Life; Rectal Neoplasms; Treatment Outcome | 2000 |
Intravenous 5-fluorouracil versus oral doxifluridine as preoperative concurrent chemoradiation for locally advanced rectal cancer: prospective randomized trials.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Combined Modality Therapy; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Prospective Studies; Quality of Life; Rectal Neoplasms | 2001 |
Variations in 5-fluorouracil concentrations of colorectal tissues as compared with dihydropyrimidine dehydrogenase (DPD) enzyme activities and DPD messenger RNA levels.
Topics: Antimetabolites, Antineoplastic; Colon; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Oxidoreductases; Rectum; RNA, Messenger | 2001 |
Preoperative chemoradiation in patients with resectable rectal cancer: results on tumor response.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Rectal Neoplasms; Treatment Outcome | 2002 |
Oral doxifluridine plus leucovorin in metastatic colorectal cancer: randomized phase II trial with intravenous 5-fluorouracil plus leucovorin.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Survival Analysis | 2003 |
Population pharmacokinetics and concentration-effect relationships of capecitabine metabolites in colorectal cancer patients.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; beta-Alanine; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Male; Middle Aged | 2003 |
A randomized controlled trial of postoperative adjuvant immunochemotherapy for colorectal cancer with oral medicines.
Topics: Adjuvants, Immunologic; Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Immunosuppressive Agents; Lymphatic Metastasis; Male; Middle Aged; Prognosis; Recurrence; Time Factors; Treatment Outcome | 2003 |
Gene expression profiles of colorectal carcinoma in response to neo-adjuvant chemotherapy.
Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma; Chemotherapy, Adjuvant; Colorectal Neoplasms; Drug Interactions; Female; Floxuridine; Fluorouracil; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, fos; Humans; Infusions, Intravenous; Irinotecan; Male; Middle Aged; Neoadjuvant Therapy; Treatment Outcome; Up-Regulation | 2004 |
Pharmacokinetic and pharmacodynamic comparison of fluoropyrimidine derivatives, capecitabine and 5'-deoxy-5-fluorouridine (5'-DFUR).
Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Area Under Curve; Breast Neoplasms; Capecitabine; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Middle Aged | 2005 |
Pharmacokinetic modelling of 5-FU production from capecitabine--a population study in 40 adult patients with metastatic cancer.
Topics: Adult; Aged; Algorithms; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Camptothecin; Capecitabine; Chromatography, High Pressure Liquid; Deoxycytidine; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Humans; Irinotecan; Middle Aged; Models, Biological; Molecular Structure; Neoplasm Metastasis; Neoplasms; Prodrugs; Sesquiterpenes | 2005 |
A phase II study of irinotecan in combination with doxifluridine, an intermediate form of capecitabine, in patients with metastatic colorectal cancer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Female; Floxuridine; Fluorouracil; Follow-Up Studies; Hematologic Diseases; Humans; Irinotecan; Leukocyte Count; Male; Middle Aged; Neoplasm Metastasis; Sample Size; Survival Analysis | 2008 |
A phase I safety, tolerability, and pharmacokinetic study of enzastaurin combined with capecitabine in patients with advanced solid tumors.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Capecitabine; Cohort Studies; Deoxycytidine; Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Follow-Up Studies; Humans; Indoles; Male; Middle Aged; Monocytes; Neoplasms; Phosphorylation; Protein Kinase C; Protein Kinase C beta | 2008 |
Plasma disposition of capecitabine and its metabolites 5'DFCR and 5'DFUR in a standard and dose-intensified monotherapy regimen.
Topics: Aged; Antimetabolites, Antineoplastic; Area Under Curve; Capecitabine; Colorectal Neoplasms; Cross-Over Studies; Deoxycytidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged | 2011 |
Higher capecitabine AUC in elderly patients with advanced colorectal cancer (SWOGS0030).
Topics: Age Factors; Aged; Antimetabolites, Antineoplastic; Area Under Curve; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Female; Floxuridine; Fluorouracil; Glomerular Filtration Rate; Humans; Male; Metabolic Clearance Rate; Middle Aged; Sex Factors | 2013 |
Simultaneous determination of capecitabine and its three nucleoside metabolites in human plasma by high performance liquid chromatography-tandem mass spectrometry.
Topics: Antimetabolites, Antineoplastic; Capecitabine; Chromatography, High Pressure Liquid; Deoxycytidine; Floxuridine; Fluorouracil; Humans; Male; Neoplasms; Tandem Mass Spectrometry; Therapeutic Equivalency | 2015 |
Pharmacokinetics and pharmacogenetics of capecitabine and its metabolites following replicate administration of two 500 mg tablet formulations.
Topics: Activation, Metabolic; Administration, Oral; Adult; Aged; Alleles; Antimetabolites, Antineoplastic; Area Under Curve; Capecitabine; Carboxylesterase; Cytidine Deaminase; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Female; Floxuridine; Fluorouracil; Genotype; Humans; Liver; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Neoplasm Proteins; Polymorphism, Single Nucleotide; Prodrugs; Tablets; Therapeutic Equivalency; Thymidine Phosphorylase; Thymidylate Synthase | 2015 |
Randomized Controlled Trial of Adjuvant Chemotherapy with Fluoropyrimidines
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Staging; Stomach Neoplasms; Survival Analysis; Tegafur; Uracil | 2017 |
201 other study(ies) available for fluorouracil and doxifluridine
| Article | Year |
|---|---|
Synthesis and interaction with uridine phosphorylase of 5'-deoxy-4',5-difluorouridine, a new prodrug of 5-fluorouracil.
Topics: Animals; Antineoplastic Agents; Floxuridine; Fluorouracil; Hydrolysis; Kinetics; Mice; Mice, Inbred DBA; Pentosyltransferases; Pharmaceutical Preparations; Prodrugs; Tumor Cells, Cultured; Uridine Phosphorylase | 1988 |
Synthesis and biological activity of 5'-substituted 5-fluoropyrimidine nucleosides.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Humans; Leukemia L1210; Mice; Mice, Inbred DBA; Uridine | 1982 |
Synthesis and in vivo antitumor activity of potential 5-fluorouracil prodrugs.
Topics: Animals; Antineoplastic Agents; Cell Survival; Chemical Phenomena; Chemistry; Fluorouracil; Leukemia L1210; Leukemia P388; Male; Mice | 1982 |
Nucleosides and nucleotides. 122. 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine and its derivatives. A new class of nucleoside with a broad antitumor spectrum.
Topics: Adenine; Animals; Antineoplastic Agents; Cytarabine; Female; Fluorouracil; Humans; Leukemia L1210; Lymphoma, Large B-Cell, Diffuse; Mice; Molecular Structure; Neoplasm Transplantation; Structure-Activity Relationship; Thymine; Tumor Cells, Cultured; Uracil | 1993 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
A comparative study of the antitumor activities of 5'-deoxy-5-fluorouridine and its prodrug trimethoxybenzoyl-5'-deoxy-5-fluorocytidine (Ro09-1390) on human digestive organ cancer xenograft lines transplanted into nude mice.
Topics: Animals; Antineoplastic Agents; Deoxycytidine; Digestive System Neoplasms; Floxuridine; Fluorouracil; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Prodrugs; Transplantation, Heterologous | 1992 |
Reversal of resistance to doxifluridine and fluorouracil in metastatic colorectal cancer: the role of high-dose folinic acid.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Resistance; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Metastasis | 1992 |
Effect of folinic acid on fluorouracil activity and expression of thymidylate synthase.
Topics: Animals; Colonic Neoplasms; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Leucovorin; Mice; Mice, Inbred BALB C; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured; Uridine Monophosphate | 1992 |
Evaluation of antiproliferative agents using a cell-culture model.
Topics: Animals; Bleomycin; Cell Count; Cell Division; Cells, Cultured; Colorimetry; Cricetinae; Cytarabine; Drug Evaluation, Preclinical; Floxuridine; Fluorouracil; Tetrazolium Salts; Thiazoles; Time Factors; Uridine | 1990 |
Activation and cytotoxicity of 5'-deoxy-5-fluorouridine in c-H-ras transformed NIH 3T3 cells.
Topics: Animals; Biotransformation; Cell Survival; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Genes, ras; Mice; Mice, Nude; Structure-Activity Relationship; Transfection; Tumor Cells, Cultured | 1991 |
[5-fluorouracil concentration in gastroenterological tumor tissues, in adjacent normal tissues, and in serum after preoperative oral administration of 5'-deoxy-5-fluorouridine (5'-DFUR)].
Topics: Administration, Oral; Colonic Neoplasms; Floxuridine; Fluorouracil; Gallbladder Neoplasms; Humans; Stomach Neoplasms | 1991 |
[5-Fluorouracil level and pyrimidine nucleoside phosphorylase activity in cancer patients after oral administration of doxifluridine (5'-DFUR)].
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Aged, 80 and over; Breast Neoplasms; Colonic Neoplasms; Enzyme Activation; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Pentosyltransferases; Pyrimidine Phosphorylases; Stomach Neoplasms | 1991 |
[Comparative studies on the antitumor activity of fluorinated pyrimidine derivatives against human bladder, cervical and ovarian cancer xenografts in nude mice].
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Female; Floxuridine; Fluorouracil; Humans; Mice; Mice, Nude; Ovarian Neoplasms; Tegafur; Uracil; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms | 1991 |
[Phase II study of 5'-DFUR treatment of the bladder and prostatic cancer].
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anorexia; Antineoplastic Agents; Diarrhea; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Multicenter Studies as Topic; Nausea; Prostatic Neoplasms; Urinary Bladder Neoplasms | 1991 |
[Investigation of 5-fluorouracil (5-FU) levels and pyrimidine nucleoside phosphorylase activities in the tissues from patients with uterine cervical and ovarian cancers after oral administration of 5'-DFUR].
Topics: Administration, Oral; Antineoplastic Agents; Female; Floxuridine; Fluorouracil; Humans; Lymph Nodes; Ovarian Neoplasms; Ovary; Pentosyltransferases; Pyrimidine Phosphorylases; Uterine Cervical Neoplasms; Uterus | 1991 |
Comparative antitumor activity of 5-fluorouracil and its prodrugs in combination with hyperthermia in vitro.
Topics: Antineoplastic Agents; Cell Survival; Floxuridine; Fluorouracil; Hot Temperature; Humans; Infant, Newborn; Prodrugs; Tegafur; Tumor Cells, Cultured | 1991 |
Pharmacokinetic study of doxifluridine given by 5-day stepped-dose infusion.
Topics: Adult; Aged; Antineoplastic Agents; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms | 1990 |
In vivo 19F NMR spectroscopy of the antimetabolite 5-fluorouracil and its analogues. An assessment of drug metabolism.
Topics: Animals; Antineoplastic Agents; beta-Alanine; Carcinoid Tumor; Female; Floxuridine; Fluorouracil; Infusions, Intravenous; Liver; Magnetic Resonance Spectroscopy; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Tegafur | 1990 |
Comparative antitumor activity and intestinal toxicity of 5'-deoxy-5-fluorouridine and its prodrug trimethoxybenzoyl-5'-deoxy-5-fluorocytidine.
Topics: Animals; Antineoplastic Agents; Deoxycytidine; Floxuridine; Fluorouracil; Intestines; Male; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Prodrugs | 1990 |
[A study on preoperative administration of doxifluridine in carcinoma of the colon and rectum].
Topics: Adenocarcinoma; Administration, Oral; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Lymph Nodes; Preoperative Care | 1990 |
[Chemotherapy with fluoropyrimidines for MOPC-104E plasmacytoma transplanted in mice with CCl4 induced chronic liver dysfunction].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Floxuridine; Fluorouracil; Male; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Plasmacytoma; Tegafur; Uracil | 1990 |
Optimal treatment regimens for 5'-deoxy-5-fluorouridine, with or without (E)-5-(2-bromovinyl)-2'-deoxyuridine, against various tumors in mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antiviral Agents; Bromodeoxyuridine; Colonic Neoplasms; Drug Therapy, Combination; Floxuridine; Fluorouracil; Liver Neoplasms; Lung Neoplasms; Mice; Mice, Inbred BALB C; Pentosyltransferases; Prodrugs; Pyrimidine Phosphorylases | 1990 |
[The study of 5-FU levels and pyrimidine nucleoside phosphorylase (PyNPase) activity in human breast cancer tissue after administration of 5'-deoxy-5-fluorouridine (5'-DFUR)].
Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Middle Aged; Pentosyltransferases; Pyrimidine Phosphorylases | 1990 |
[Preoperative chemotherapy and anti-cancer effect of gastric carcinoma].
Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Drug Evaluation; Floxuridine; Fluorouracil; Gastrectomy; Humans; Middle Aged; Neoplasm Staging; Preoperative Care; Stomach Neoplasms | 1990 |
Kinetic analysis of 5-fluorouracil action against various cancer cells.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Colonic Neoplasms; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Humans; Kidney Neoplasms; Leukemia P388; Mice; RNA, Ribosomal; S Phase; Time Factors; Uridine | 1990 |
[A study on pre-operative administration of 5'-DFUR in carcinomas of the gastric, breast, thyroid and colon].
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Cycle; Colonic Neoplasms; Combined Modality Therapy; Female; Floxuridine; Fluorouracil; Humans; Lymph Nodes; Pentosyltransferases; Preoperative Care; Pyrimidine Phosphorylases; Stomach Neoplasms; Thyroid Neoplasms; Tissue Distribution | 1990 |
[5'-Deoxy-5-fluorouridine and 5-fluorouracil concentrations and thymidine phosphorylase activity in brain tumors following intravenous administration of 5'-deoxy-5-fluorouridine].
Topics: Adult; Aged; Astrocytoma; Brain Neoplasms; Cerebral Ventricle Neoplasms; Child; Choroid Plexus; Ependymoma; Female; Floxuridine; Fluorouracil; Glioma; Humans; Infant; Male; Middle Aged; Papilloma; Pentosyltransferases; Thymidine Phosphorylase | 1985 |
Modulation of cytotoxicity and metabolism of 5-fluorouracil in two intestine cell lines.
Topics: Cell Cycle; Cell Line; DNA; Drug Synergism; Floxuridine; Fluorouracil; Humans; Hypoxanthine; Hypoxanthines; In Vitro Techniques; Inosine; Organophosphorus Compounds; Pentosyltransferases; Pyrimidine Phosphorylases; Ribosemonophosphates; RNA; Thymidine; Thymidylate Synthase | 1986 |
Correlation between ribosomal RNA production and RNA-directed fluoropyrimidine cytotoxicity.
Topics: Animals; Cell Nucleus; Cell Survival; Cytoplasm; DNA; Floxuridine; Fluorouracil; Mice; RNA; RNA, Messenger; RNA, Ribosomal; Sarcoma 180; Uridine | 1987 |
[The serum and tissue concentration of FT-207, 5'-DFUR and 5-FU in patients with breast cancer by preoperative administration of UFT and 5'-DFUR].
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast; Breast Neoplasms; Floxuridine; Fluorouracil; Humans; Lymph Nodes; Preoperative Care; Tegafur; Tissue Distribution; Uracil | 1989 |
Enhanced therapeutic efficacy of 5'deoxy-5-fluorouridine in 5-fluorouracil resistant head and neck tumours in relation to 5-fluorouracil metabolising enzymes.
Topics: Animals; Antineoplastic Agents; Carcinoma; Colonic Neoplasms; Drug Resistance; Female; Floxuridine; Fluorouracil; Head and Neck Neoplasms; Isomerism; Mice; Mice, Nude; Neoplasm Transplantation; Pentosyltransferases; Pyrimidine Phosphorylases | 1989 |
Enhanced antitumor effect of 5'-deoxy-5-fluorouridine by oral administration with L-cysteine.
Topics: Adenocarcinoma; Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Chromatography, High Pressure Liquid; Colonic Neoplasms; Cysteine; Drug Synergism; Floxuridine; Fluorouracil; Humans; Injections, Intravenous; Lung Neoplasms; Male; Mice | 1989 |
[Two cases of gastrointestinal cancers with major responses to sequential methotrexate 5-FU plus 5'-DFUR].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carcinoembryonic Antigen; Colonic Neoplasms; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Lymphatic Metastasis; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Remission Induction; Stomach Neoplasms | 1989 |
Enhancing effect of bromovinyldeoxyuridine on antitumor activity of 5'-deoxy-5-fluorouridine against adenocarcinoma 755 in mice. Correlation with pharmacokinetics of plasma 5-fluorouracil levels.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Bromodeoxyuridine; Chromatography, High Pressure Liquid; Drug Synergism; Floxuridine; Fluorouracil; Half-Life; Male; Mice; Neoplasm Transplantation; Spectrophotometry, Ultraviolet | 1989 |
Comparative antitumor activity of 5-fluorouracil and 5'-deoxy-5-fluorouridine in combination with radiation therapy in mice bearing colon 26 adenocarcinoma.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Bone Marrow; Colonic Neoplasms; Combined Modality Therapy; Female; Floxuridine; Fluorouracil; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Spleen; Thymus Gland; Weight Gain | 1989 |
Fluoropyrimidine metabolism in human head and neck cancer xenografts and murine colon tumors.
Topics: Animals; Colonic Neoplasms; Drug Screening Assays, Antitumor; Floxuridine; Fluorouracil; Head and Neck Neoplasms; Humans; Mice; Neoplasm Transplantation; Orotate Phosphoribosyltransferase; Pentosyltransferases; Pyrimidine Phosphorylases; Tumor Cells, Cultured | 1989 |
[Anticancer treatment with a combination of antimetabolites of polyamine and pyrimidine].
Topics: Animals; DNA Replication; Drug Therapy, Combination; Eflornithine; Floxuridine; Fluorouracil; Mice; Mice, Nude; Mitoguazone; Ornithine; Polyamines; Spermine; Stomach Neoplasms | 1985 |
Pharmacology of 5'-deoxy-5-fluorouridine in patients with resistant ovarian cancer.
Topics: Adult; Aged; Antineoplastic Agents; Female; Floxuridine; Fluorouracil; Humans; Kinetics; Middle Aged; Ovarian Neoplasms | 1985 |
Analysis of 5'-deoxy-5-fluorouridine and 5-fluorouracil in human plasma and urine by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Floxuridine; Fluorouracil; Humans; Hydrogen-Ion Concentration; Kinetics; Spectrophotometry, Ultraviolet | 1985 |
The therapeutic effects of orally administered 5'-deoxy-5-fluorouridine, 1-(2-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil on experimental murine tumors.
Topics: Animals; Antineoplastic Agents; Floxuridine; Fluorouracil; Leukemia L1210; Mice; Neoplasms, Experimental; Tegafur | 1985 |
Evidence for the importance of 5'-deoxy-5-fluorouridine catabolism in humans from 19F nuclear magnetic resonance spectrometry.
Topics: Aged; Antineoplastic Agents; beta-Alanine; Female; Floxuridine; Fluorouracil; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Urea | 1986 |
Precursor-dependent differences in the incorporation of fluorouracil in RNA.
Topics: Animals; Cell Survival; Cells, Cultured; Floxuridine; Fluorouracil; Mice; RNA, Neoplasm; Sarcoma, Experimental; Thymidine; Uridine | 1986 |
Combined therapy of polyamine antimetabolites and antitumor drugs for human gastric cancer xenotransplanted into nude mice.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Carcinoma; Eflornithine; Floxuridine; Fluorouracil; Mice; Mice, Inbred BALB C; Mice, Nude; Mitoguazone; Neoplasm Transplantation; Nimustine; Nitrosourea Compounds; Ornithine; Stomach Neoplasms | 1986 |
Noninvasive fluorine-19 NMR study of fluoropyrimidine metabolism in cell cultures of human pancreatic and colon adenocarcinoma.
Topics: Adenocarcinoma; Cells, Cultured; Colonic Neoplasms; Floxuridine; Fluorine; Fluorouracil; Humans; Macromolecular Substances; Magnetic Resonance Spectroscopy; Pancreatic Neoplasms; Spectrum Analysis | 1986 |
Toxicity and antitumor effect of 5-fluorouracil and its rescue by uridine.
Topics: Animals; Body Temperature Regulation; Carcinoma; Colonic Neoplasms; Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Hematopoiesis; Leukocyte Count; Mice; Uridine | 1986 |
Passage of 5'-dFUrd and its metabolites 5-FU and 5-FUH2 to CSF in a clinical phase 1 study.
Topics: Adult; Aged; Drug Evaluation; Female; Floxuridine; Fluorouracil; Humans; Kinetics; Male; Middle Aged | 1986 |
Role of administration route in the therapeutic efficacy of doxifluridine.
Topics: Administration, Oral; Animals; Biological Availability; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Infusions, Intravenous; Injections, Intravenous; Kinetics; Neoplasm Transplantation; Rats; Rats, Inbred F344 | 1987 |
Enzymatic cleavage of various fluorinated pyrimidine nucleosides to 5-fluorouracil and their antiproliferative activities in human and murine tumor cells.
Topics: Animals; Cell Division; Floxuridine; Fluorouracil; Humans; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Substrate Specificity; Thymidine Phosphorylase; Uridine Phosphorylase | 1986 |
[Combination chemotherapy with 3 or 4 drugs on human breast and gastrointestinal cancer xenografts in nude mice (II)].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Colonic Neoplasms; Cyclophosphamide; Doxorubicin; Female; Floxuridine; Fluorouracil; Humans; Methotrexate; Mice; Mice, Nude; Mitomycin; Mitomycins; Neoplasm Transplantation; Stomach Neoplasms; Tegafur; Vindesine | 1987 |
[5'-DFUR (doxifluridine)].
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Drug Evaluation; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Humans; Liver Neoplasms, Experimental; Mice; Sarcoma, Experimental | 1987 |
Reduced hippocampal field potentials during administration of fluoropyrimidines in vitro.
Topics: Action Potentials; Animals; Evoked Potentials; Floxuridine; Fluorouracil; Hippocampus; In Vitro Techniques; Nerve Fibers; Rats; Rats, Inbred Strains; Synapses | 1987 |
[Conversion of 5'-deoxy-5-fluorouridine to 5-FU by pyrimidine nucleoside phosphorylases in normal and tumor tissues from rodents bearing tumors and cancer patients].
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Floxuridine; Fluorouracil; Humans; Leukemia L1210; Leukemia P388; Mice; Neoplasms; Neoplasms, Experimental; Pentosyltransferases; Pyrimidine Phosphorylases; Rats; Sarcoma 180 | 1987 |
[Comparative studies on the antitumor activity of the fluorinated pyrimidines 5'-DFUR, tegafur, UFT and FUra on various murine tumors].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Floxuridine; Fluorouracil; Leukemia P388; Liver Neoplasms, Experimental; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Neoplasms, Experimental; Sarcoma 180; Tegafur; Uracil | 1988 |
Comparison of the pyrimidine nucleoside phosphorylase activity in human tumors and normal tissues.
Topics: Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; In Vitro Techniques; Pentosyltransferases; Prodrugs; Pyrimidine Phosphorylases; Spectrophotometry; Stomach Neoplasms | 1988 |
Determination of 5-fluorouracil in plasma and liver after oral administration of 5'-deoxy-5-fluorouridine using gas chromatography-mass spectrometry.
Topics: Administration, Oral; Adult; Floxuridine; Fluorouracil; Gas Chromatography-Mass Spectrometry; Humans; Liver; Middle Aged | 1988 |
Inhibition of thymidylate synthase after administration of doxifluridine in a transplantable colon carcinoma in the rat.
Topics: Animals; Carcinoma; Colonic Neoplasms; Female; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Male; Neoplasm Transplantation; Rats; Rats, Inbred Strains; Thymidylate Synthase | 1988 |
The in vitro stability of doxifluridine in whole blood and plasma.
Topics: Drug Stability; Floxuridine; Fluorouracil; Half-Life; Humans | 1988 |
The antiproliferative effects of fluoropyrimidine derivatives against human tumor xenografts in a subrenal capsule assay.
Topics: Animals; Antineoplastic Agents; Body Weight; Cell Division; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Male; Mice; Mice, Nude; Stomach Neoplasms; Subrenal Capsule Assay; Tegafur; Transplantation, Heterologous | 1988 |
5-Fluoro-5'-deoxyuridine is an inhibitor of uridylate nucleotidase in L1210 leukaemia.
Topics: 5'-Nucleotidase; Animals; Antimetabolites, Antineoplastic; Biotransformation; Cell Cycle; DNA, Neoplasm; Floxuridine; Fluorouracil; Leukemia L1210; Mice; Nucleotidases; Pentosyltransferases; Pyrimidine Phosphorylases; RNA, Neoplasm; Thymidylate Synthase | 1986 |
Elevation of plasma levels of fluorinated pyrimidines by guanosine 5'-monophosphate.
Topics: Animals; Deoxycytidine; Drug Interactions; Floxuridine; Fluorouracil; Guanine Nucleotides; Guanosine Monophosphate; Guanosine Triphosphate; Inosine Monophosphate; Male; Mice | 1987 |
[Experimental results of survivals with different dose schedule of 5-FU and 5'-DFUR].
Topics: Animals; Antineoplastic Agents; Drug Administration Schedule; Floxuridine; Fluorouracil; Lung Neoplasms; Male; Mice | 1985 |
The degradation of 5'-deoxy-5-fluorouridine by pyrimidine nucleoside phosphorylase in normal and cancer tissues.
Topics: Animals; Colon; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Humans; Hydrogen-Ion Concentration; Intestine, Small; Kinetics; Lymph Nodes; Mice; Pentosyltransferases; Pyrimidine Phosphorylases; Spectrophotometry, Ultraviolet; Tissue Distribution | 1985 |
Reversed-phase ion-pair high-performance liquid chromatographic assay of 5-fluorouracil, 5'-deoxy-5-fluorouridine, their nucleosides, mono-, di-, and triphosphate nucleotides with a mixture of quaternary ammonium ions.
Topics: Chromatography, High Pressure Liquid; Deoxyuracil Nucleotides; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Isomerism; Structure-Activity Relationship; Uracil Nucleotides; Uridine | 1982 |
Modulation of 1-beta-D-arabinofuranosylcytosine metabolism and cytotoxicity in L1210 cells by fluoropyrimidine pretreatment.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Cell Line; Cell Survival; Clone Cells; Cytarabine; Deoxyribonucleotides; Deoxyuridine; Drug Interactions; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Leukemia L1210; Mice; Uridine | 1982 |
Quantitative analysis of 5-fluorouracil and 5,6-dihydrofluorouracil in plasma by gas chromatography mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Floxuridine; Fluorouracil; Gas Chromatography-Mass Spectrometry; Humans; Time Factors; Uracil | 1982 |
Evidence that 5'-deoxy-5-fluorouridine may not be activated by the same mechanism as 5-fluorouracil.
Topics: Animals; Biotransformation; Cells, Cultured; Floxuridine; Fluorouracil; Inosine; Liver Neoplasms, Experimental | 1982 |
Studies on the designing of chemotherapy for gastric cancer in man, based on the tumor tissue concentration of anticancer agents.
Topics: Antineoplastic Agents; Floxuridine; Fluorouracil; Gastric Mucosa; Humans; Stomach Neoplasms; Tegafur | 1982 |
Differential selectivity of 5-fluorouracil and 5'-deoxy-5-fluorouridine in cultured human B lymphocytes and mouse L1210 leukemia.
Topics: Animals; Antineoplastic Agents; Ascitic Fluid; B-Lymphocytes; Biotransformation; Cell Division; Cells, Cultured; DNA; Female; Floxuridine; Fluorouracil; Humans; Leukemia L1210; Mice; Mice, Inbred DBA; Uridine Phosphorylase | 1983 |
5'-Deoxy-5-fluorouridine selective toxicity for human tumor cells compared to human bone marrow.
Topics: Antineoplastic Agents; Bone Marrow; Breast Neoplasms; Cell Survival; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; Leukemia, Myeloid, Acute; Neoplasms; Osteosarcoma | 1983 |
Decreased immunosuppression associated with antitumor activity of 5-deoxy-5-fluorouridine compared to 5-fluorouracil and 5-fluorouridine.
Topics: Animals; Antineoplastic Agents; Cell Survival; Female; Floxuridine; Fluorouracil; Immunosuppression Therapy; Inflammation; Male; Mice; Mice, Inbred C57BL; Pyrans; Thioglycolates; Uridine | 1983 |
[Pharmacological and pharmacodynamic aspects of cancer chemotherapy, with special reference to 5-fluorouracil and its derivatives].
Topics: Antineoplastic Combined Chemotherapy Protocols; Drug Combinations; Floxuridine; Fluorouracil; Humans; Kinetics; Neoplasms; Tegafur; Uracil | 1982 |
Simultaneous analysis of 5'-deoxy-5-fluorouridine and 5-fluorouracil in plasma by analytical isotachophoresis.
Topics: Electrophoresis; Floxuridine; Fluorouracil; Humans | 1983 |
Tumor specific conversion of a pyrimidine antimetabolite.
Topics: Animals; Antineoplastic Agents; Cell Line; Floxuridine; Fluorouracil; Isomerism; Mice; Neoplasms, Experimental | 1984 |
31P-topical nuclear magnetic resonance (31P-TMR) studies of cardiotoxic effects of 5-fluorouracil (5-FU) and 5'-deoxy-5-fluorouridine (5'-DFUR).
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Electrocardiography; Floxuridine; Fluorouracil; Guinea Pigs; Heart; Magnetic Resonance Spectroscopy; Male; Myocardium; Phosphocreatine | 1984 |
[5'-Deoxy-5-fluorouridine enzymatic activation from the masked compound to 5-fluorouracil in human malignant tissues].
Topics: Administration, Oral; Aged; Animals; Antineoplastic Agents; Enzyme Activation; Female; Floxuridine; Fluorouracil; Humans; Infusions, Parenteral; Liver Neoplasms; Lung Neoplasms; Male; Mice; Neoplasms; Pentosyltransferases; Pyrimidine Phosphorylases; Sarcoma, Experimental; Stomach Neoplasms; Uridine Phosphorylase; Uterine Neoplasms | 1984 |
[Measurement of 5'-deoxy-5-fluorouridine (5'-DFUR) by high-performance liquid chromatography and studies on pharmacokinetics of 5'-DFUR and 5-fluorouracil by oral and intravenous administration].
Topics: Administration, Oral; Aged; Chromatography, High Pressure Liquid; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Injections, Intravenous; Kinetics; Male; Middle Aged; Stomach Neoplasms | 1984 |
[Development of fluoropyrimidine derivatives].
Topics: Animals; DNA Replication; Floxuridine; Fluorouracil; Mice; Phosphorylation; Pyrimidine Nucleotides; Rats; Sarcoma, Experimental; Tegafur; Uracil | 1984 |
Prognostic factors and in vitro cytotoxic sensitivity in colorectal cancer.
Topics: Antineoplastic Agents; Cell Division; Cell Survival; Cells, Cultured; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; Neoplasm Staging; Prognosis; Rectal Neoplasms; Thymidine; Tumor Stem Cell Assay | 1984 |
Metabolism and biological activity of 5'-deoxy-5-fluorouridine, a novel fluoropyrimidine.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cells, Cultured; Chromatography, Liquid; Floxuridine; Fluorouracil; Male; Mice; Neoplasm Transplantation; Phosphotransferases; Structure-Activity Relationship; Thymidylate Synthase | 1980 |
Role of uridine phosphorylase for antitumor activity of 5'-deoxy-5-fluorouridine.
Topics: Animals; Biotransformation; Floxuridine; Fluorouracil; Leukemia L1210; Male; Mice; Pentosyltransferases; Sarcoma 180; Tegafur; Thymidine; Uridine; Uridine Phosphorylase | 1980 |
Comparative studies on the immunosuppressive effect among 5'-deoxy-5-fluorouridine, ftorafur, and 5-fluorouracil.
Topics: Animals; Antibody Formation; Erythrocytes; Female; Floxuridine; Fluorouracil; Graft Rejection; Hypersensitivity, Delayed; Immunity, Cellular; Immunosuppressive Agents; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation; Tegafur | 1980 |
Tissue distribution of 5'-deoxy-5-fluorouridine and derived 5-fluorouracil in tumor-bearing mice and rats.
Topics: Animals; Carcinoma 256, Walker; Female; Floxuridine; Fluorouracil; Male; Mice; Rats; Sarcoma 180; Tegafur; Tissue Distribution | 1980 |
Increased sensitivity to the prodrug 5'-deoxy-5-fluorouridine and modulation of 5-fluoro-2'-deoxyuridine sensitivity in MCF-7 cells transfected with thymidine phosphorylase.
Topics: Antineoplastic Agents; Biological Availability; Breast; Breast Neoplasms; Cell Communication; Cell Division; Drug Screening Assays, Antitumor; Floxuridine; Fluorouracil; Humans; Prodrugs; Thymidine; Thymidine Phosphorylase; Transfection; Tumor Cells, Cultured | 1995 |
Sensitivity of human KB cells expressing platelet-derived endothelial cell growth factor to pyrimidine antimetabolites.
Topics: Cell Division; Floxuridine; Fluorouracil; Humans; KB Cells; RNA; Tegafur; Thymidine Kinase; Thymidine Phosphorylase; Transfection | 1993 |
Interferon alpha and 5'-deoxy-5-fluorouridine in colon cancer: effects as single agents and in combination on growth of xenograft tumours.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Combined Modality Therapy; Floxuridine; Fluorouracil; Humans; Interferon Type I; Male; Mice; Mice, Nude; Neoplasm Transplantation; Pentosyltransferases; Prodrugs; Pyrimidine Phosphorylases; Recombinant Proteins; Transplantation, Heterologous | 1994 |
Differential effects of acyclothymidine, a potent pyrimidine nucleoside phosphorylase inhibitor, on the pharmacokinetics of doxifluridine in rabbits via oral administration.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Drug Interactions; Floxuridine; Fluorouracil; Male; Pentosyltransferases; Pyrimidine Phosphorylases; Rabbits; Uracil | 1993 |
[A comparative study on the serum and tissue 5-FU concentrations in patients with hepatocellular carcinoma after preoperative oral administration of UFT and 5'-DFUR].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Chemotherapy, Adjuvant; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Liver; Liver Neoplasms; Male; Middle Aged; Tegafur; Uracil | 1994 |
The significance of preoperative chemotherapy for early gastric carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Staging; Preoperative Care; Prognosis; Stomach Neoplasms; Tegafur; Uracil | 1993 |
[Study on the relationship between concentrations of 5-FU and PyNPase activity in tumor tissue during oral 5'-DFUR treatment in patients with advanced colorectal cancer].
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Antineoplastic Agents; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Pentosyltransferases; Pyrimidine Phosphorylases | 1994 |
Differences in activities and substrate specificity of human and murine pyrimidine nucleoside phosphorylases: implications for chemotherapy with 5-fluoropyrimidines.
Topics: Animals; Floxuridine; Fluorouracil; Humans; Liver; Mice; Placenta; Species Specificity; Substrate Specificity; Thymidine Phosphorylase; Uridine; Uridine Phosphorylase | 1993 |
Cytokines induce thymidine phosphorylase expression in tumor cells and make them more susceptible to 5'-deoxy-5-fluorouridine.
Topics: Antineoplastic Agents; Blotting, Northern; Cell Division; Colonic Neoplasms; Cytokines; Depression, Chemical; Drug Synergism; Enzyme Induction; Floxuridine; Fluorouracil; Humans; Interferon-gamma; Interleukin-1; RNA, Messenger; Stomach Neoplasms; Thymidine Phosphorylase; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1993 |
Functional effects of a naturally occurring amino acid substitution in human thymidylate synthase.
Topics: Base Sequence; Binding Sites; Floxuridine; Fluorouracil; Histidine; Humans; Hydrogen-Ion Concentration; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Temperature; Tetrahydrofolates; Thymidylate Synthase; Tumor Cells, Cultured; Tyrosine | 1993 |
Solid-phase extraction of fluoropyrimidine derivatives on a copper-modified strong cation exchanger: determination of doxifluridine, 5-fluorouracil and its main metabolites in serum by high-performance liquid chromatography with ultraviolet detection.
Topics: Adsorption; Antineoplastic Agents; Cations; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Copper; Floxuridine; Fluorouracil; Humans; Isomerism; Spectrophotometry, Ultraviolet | 1993 |
Cytokines induce uridine phosphorylase in mouse colon 26 carcinoma cells and make the cells more susceptible to 5'-deoxy-5-fluorouridine.
Topics: Animals; Antineoplastic Agents; Cell Division; Colonic Neoplasms; Cytokines; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Induction; Fibroblast Growth Factor 2; Floxuridine; Fluorouracil; Interferon-gamma; Interleukin-1; Mice; RNA, Neoplasm; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Uridine; Uridine Phosphorylase | 1993 |
Modulation of the pharmacokinetics of 5'-deoxy-5-fluorouridine and 5-fluorouracil in rats by oral co-administration of acyclothymidine.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Drug Interactions; Enzyme Inhibitors; Floxuridine; Fluorouracil; Intestines; Liver; Male; Pentosyltransferases; Pyrimidine Phosphorylases; Rats; Uracil | 1996 |
[Intra-arterial infusion chemotherapy for liver metastases from breast cancer].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Administration Schedule; Epirubicin; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Liver Neoplasms; Medroxyprogesterone; Middle Aged | 1996 |
Preparation of anti-human thymidine phosphorylase monoclonal antibodies useful for detecting the enzyme levels in tumor tissues.
Topics: Animals; Antibodies, Monoclonal; Enzyme-Linked Immunosorbent Assay; Floxuridine; Fluorouracil; Humans; Male; Mice; Mice, Inbred BALB C; Neoplasms; Thymidine Phosphorylase | 1996 |
[Pyrimidine nucleoside phosphorylase activity, 5-fluorouracil concentration and thymidylate synthase inhibition rate in colorectal cancer after oral administration of 5'-doxifluridine].
Topics: Adenocarcinoma; Administration, Oral; Aged; Antineoplastic Agents; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Pentosyltransferases; Pyrimidine Phosphorylases; Thymidylate Synthase | 1997 |
Positive correlation between the efficacy of capecitabine and doxifluridine and the ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase activities in tumors in human cancer xenografts.
Topics: Animals; Antineoplastic Agents; Capecitabine; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Floxuridine; Fluorouracil; Humans; Mice; Neoplasm Transplantation; Oxidoreductases; Thymidine Phosphorylase | 1998 |
Effect of coadministered uridine on intestinal first-pass metabolism of 5'-deoxy-5-fluorouridine in conscious rats--an evaluation by method of portal-systemic concentration difference.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Arteries; Drug Interactions; Floxuridine; Fluorouracil; Intestinal Absorption; Intestinal Mucosa; Intestines; Male; Portal System; Portal Vein; Rats; Rats, Wistar; Uridine | 1998 |
Antitumor activities of a novel fluoropyrimidine, N4-pentyloxycarbonyl-5'-deoxy-5-fluorocytidine (capecitabine).
Topics: Analysis of Variance; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Capecitabine; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Male; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Pyrimidines; Subrenal Capsule Assay | 1998 |
[The correlation between thymidine phosphorylase activity of renal cancer cells and the chemosensitivity to 5-FU and 5'-DFUR].
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Carcinoma, Renal Cell; Drug Screening Assays, Antitumor; Floxuridine; Fluorouracil; Humans; Kidney Neoplasms; Thymidine Phosphorylase; Tumor Cells, Cultured | 1998 |
Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue.
Topics: Animals; Capecitabine; Carboxylic Ester Hydrolases; Cytidine Deaminase; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Liver; Male; Mice; Neoplasms; Thymidine Phosphorylase | 1998 |
[A case of giant advanced breast cancer responding remarkably to chemo-endocrine therapy chiefly with doxifluridine].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Carcinoma, Ductal, Breast; Cyclophosphamide; Drug Administration Schedule; Epirubicin; Female; Floxuridine; Fluorouracil; Humans; Pleural Effusion, Malignant; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen | 1998 |
Enhancement of 5-fluorouracil cytotoxicity by human thymidine-phosphorylase expression in cancer cells: in vitro and in vivo study.
Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma; Colonic Neoplasms; Drug Synergism; Floxuridine; Fluorouracil; Humans; Mice; Mice, Inbred BALB C; Neoplasm Proteins; Thymidine Phosphorylase; Transfection | 1999 |
[Effective chemo-endocrine combination therapy for obstructive-jaundice caused by multiple liver metastasis of recurrent breast cancer--a case report].
Topics: Aged; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cholestasis; Cyclophosphamide; Doxorubicin; Drainage; Female; Floxuridine; Fluorouracil; Humans; Liver Neoplasms; Lung Neoplasms; Mastectomy, Radical; Medroxyprogesterone Acetate; Tamoxifen; Tegafur; Toremifene; Uracil | 1999 |
[A case of breast cancer with liver metastases responding remarkably to combination therapy of mitoxantrone (MIT), doxifluridine (5'-DFUR) and medroxyprogesterone acetate (MPA)].
Topics: Administration, Oral; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Drug Resistance, Neoplasm; Epirubicin; Female; Floxuridine; Fluorouracil; Humans; Liver Neoplasms; Medroxyprogesterone Acetate; Middle Aged; Mitoxantrone; Tamoxifen | 1999 |
Induction of thymidine phosphorylase expression and enhancement of efficacy of capecitabine or 5'-deoxy-5-fluorouridine by cyclophosphamide in mammary tumor models.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Capecitabine; Cyclophosphamide; Deoxycytidine; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Humans; Kinetics; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasm Transplantation; Thymidine Phosphorylase; Time Factors; Up-Regulation | 1999 |
Increased cytotoxicity and bystander effect of 5-fluorouracil and 5-deoxy-5-fluorouridine in human colorectal cancer cells transfected with thymidine phosphorylase.
Topics: Adenocarcinoma; Antineoplastic Agents; Cell Survival; Cloning, Molecular; Colorectal Neoplasms; DNA, Complementary; Floxuridine; Fluorouracil; Humans; Recombinant Proteins; Thymidine Phosphorylase; Transfection; Tumor Cells, Cultured | 1999 |
UFT and its metabolites inhibit the angiogenesis induced by murine renal cell carcinoma, as determined by a dorsal air sac assay in mice.
Topics: 4-Butyrolactone; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cell Division; Diffusion Chambers, Culture; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Hydroxybutyrates; Kidney Neoplasms; Male; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neovascularization, Pathologic; Tegafur; Tumor Cells, Cultured; Uracil | 1999 |
[Successful endocrine chemotherapy in patients with multiple bone metastases of breast cancer--a case report].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Combined Modality Therapy; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Medroxyprogesterone; Middle Aged; Tamoxifen | 1999 |
[Long-term complete response in a case of unresectable rectal cancer following chemoradiation].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Radiotherapy Dosage; Rectal Neoplasms; Remission Induction; Tegafur; Uracil | 2000 |
[A case of diffusely infiltrating carcinoma of the sigmoid colon associated with lymphangitis carcinomatosa effectively treated with sequential MTX.5-FU and 5'-DFUR].
Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Floxuridine; Fluorouracil; Humans; Lymphangitis; Male; Methotrexate; Sigmoid Neoplasms | 2000 |
[A case of recurrent breast cancer with carcinoma erysipeloides responding to sequential therapy with docetaxel (TXT) and doxifluridine (5'-DFUR) accompanied by leucovorin (LV)].
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma; Cyclophosphamide; Docetaxel; Doxorubicin; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Injections, Intra-Arterial; Leucovorin; Mastectomy; Middle Aged; Neoplasm Recurrence, Local; Paclitaxel; Skin Neoplasms; Taxoids | 2000 |
[Comparison of pharmacokinetics of 5-FU and alpha-fluoro-beta-alanine, a metabolite of 5-FU, in plasma after administration of UFT, tegafur, 5-FU or doxifluridine to rats].
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; beta-Alanine; Floxuridine; Fluorouracil; Male; Rats; Rats, Sprague-Dawley; Tegafur; Uracil | 2000 |
Disposition and availability of 5-fluorouracil prodrug 5'-deoxy-5-fluorouridine after oral administration in rats.
Topics: Absorption; Administration, Oral; Animals; Antimetabolites, Antineoplastic; Biological Availability; Female; Floxuridine; Fluorouracil; Prodrugs; Rats; Rats, Inbred F344 | 1987 |
Intratumoral pyrimidine nucleoside phosphorylase (PyNPase) activity predicts a selective effect of adjuvant 5'-deoxy-5-fluorouridine (5'DFUR) on breast cancer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Breast Neoplasms; Carcinoma, Ductal, Breast; Chemotherapy, Adjuvant; Chromatography, High Pressure Liquid; Disease-Free Survival; Female; Floxuridine; Fluorouracil; Follow-Up Studies; Humans; Lymphatic Metastasis; Mastectomy, Radical; Menopause; Middle Aged; Mitomycin; Neoplasm Proteins; Pentosyltransferases; Prodrugs; Pyrimidine Phosphorylases; Tamoxifen; Thymidine Phosphorylase; Treatment Outcome | 2000 |
[A case of locally advanced rectal carcinoma with liver metastasis treated with a combination of CRT, HAI, and systemic chemotherapy].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Combined Modality Therapy; Drug Administration Schedule; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Radiotherapy Dosage; Rectal Neoplasms; Suppositories | 2000 |
[A case of advanced breast cancer that responded remarkably to chemotherapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Medroxyprogesterone Acetate; Middle Aged | 2000 |
[A case of breast cancer with multiple organ metastases responding remarkably to combination therapy of CAF (cyclophosphamide, adriamycin and 5-FU), 5'-DFUR and MPA (medroxyprogesterone acetate)].
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Mastectomy; Medroxyprogesterone Acetate; Middle Aged; Remission Induction | 2000 |
[Advanced breast cancer with multiple bone metastases successfully treated with combined chemoendocrine-therapy of CEF (cyclophosphamide, epirubicin, 5-fluorouracil) and 5'-DFUR (5'-deoxy-5-fluorouridine) + MPA (medroxyprogesterone acetate)--a case report
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Cyclophosphamide; Drug Therapy, Combination; Epirubicin; Female; Floxuridine; Fluorouracil; Humans; Medroxyprogesterone; Middle Aged; Progesterone Congeners; Treatment Outcome | 2001 |
Enhancement of sensitivity to capecitabine in human renal carcinoma cells transfected with thymidine phosphorylase cDNA.
Topics: Animals; Antimetabolites, Antineoplastic; Capecitabine; Carcinoma, Renal Cell; Cell Survival; Deoxycytidine; Disease Models, Animal; DNA, Complementary; Drug Screening Assays, Antitumor; Floxuridine; Fluorouracil; Kidney Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Thymidine Phosphorylase; Transfection; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2001 |
Schedule dependency of antitumor activity in combination therapy with capecitabine/5'-deoxy-5-fluorouridine and docetaxel in breast cancer models.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Deoxycytidine; Disease Models, Animal; Docetaxel; Drug Administration Schedule; Drug Combinations; Female; Floxuridine; Fluorouracil; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Paclitaxel; Taxoids; Thymidine Phosphorylase; Tumor Cells, Cultured; Up-Regulation; Xenograft Model Antitumor Assays | 2001 |
Role of the human concentrative nucleoside transporter (hCNT1) in the cytotoxic action of 5[Prime]-deoxy-5-fluorouridine, an active intermediate metabolite of capecitabine, a novel oral anticancer drug.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Capecitabine; Carrier Proteins; Cell Survival; CHO Cells; Cloning, Molecular; Cricetinae; Deoxycytidine; DNA, Complementary; Drug Screening Assays, Antitumor; Fetus; Floxuridine; Fluorouracil; Humans; Liver; Membrane Transport Proteins; Oocytes; Prodrugs; Transfection; Xenopus laevis | 2001 |
Impact of thymidine phosphorylase surexpression on fluoropyrimidine activity and on tumour angiogenesis.
Topics: Animals; Antimetabolites, Antineoplastic; Colonic Neoplasms; Drug Resistance, Neoplasm; Floxuridine; Fluorouracil; Formazans; Neoplasm Transplantation; Neovascularization, Pathologic; Pentosyltransferases; Pyrimidine Phosphorylases; Rats; Tetrazolium Salts; Thymidine Phosphorylase; Transfection; Tumor Cells, Cultured | 2001 |
Thymidine phosphorylase expression is useful in selecting adjuvant chemotherapy for stage III gastric cancer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Floxuridine; Fluorouracil; Humans; Immunoenzyme Techniques; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Staging; Stomach Neoplasms; Survival Rate; Thymidine Phosphorylase; Treatment Outcome | 2001 |
Docetaxel alone or orally combined with 5-fluorouracil and its derivatives: effects on mouse mammary tumor cell line MM2 in vitro and in vivo.
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Docetaxel; Drug Synergism; Female; Floxuridine; Fluorouracil; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Paclitaxel; Prodrugs; Taxoids; Thymidine Phosphorylase; Tumor Cells, Cultured; Up-Regulation | 2001 |
[Effect of peroral doxifluridine plus hepatic arterial infusion for synchronous liver metastasis of colorectal cancer--correlation with the expression of thymidine phosphorylase and dihydropyrimidine dehydrogenase in primary colorectal cancer lesions].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Oxidoreductases; Survival Rate; Thymidine Phosphorylase | 2001 |
Plasma, intestine and tumor levels of 5-fluorouracil in mice bearing L1210 ascites tumor following oral administration of 5-fluorouracil, UFT (mixed compound of tegafur and uracil), carmofur and 5'-deoxy-5-fluorouridine.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Drug Combinations; Floxuridine; Fluorouracil; Intestinal Mucosa; Leukemia L1210; Male; Mice; Tegafur; Uracil | 2001 |
Immunohistochemical variation of human equilibrative nucleoside transporter 1 protein in primary breast cancers.
Topics: Affinity Labels; Animals; Antibodies, Monoclonal; Antibody Formation; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Deoxycytidine; Drug Resistance, Neoplasm; Equilibrative Nucleoside Transporter 1; Female; Floxuridine; Fluorouracil; Humans; Immunoenzyme Techniques; Membrane Transport Proteins; Mice; Neoplasm Invasiveness; Neoplasm Proteins; Neoplasm Staging; Thioinosine | 2002 |
gamma-Hydroxybutyric acid and 5-fluorouracil, metabolites of UFT, inhibit the angiogenesis induced by vascular endothelial growth factor.
Topics: Angiogenesis Inhibitors; Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Carcinoma; Carcinoma, Renal Cell; Chemotaxis; Colonic Neoplasms; DNA Replication; Drug Combinations; Endothelial Growth Factors; Endothelium, Vascular; Female; Fibroblast Growth Factor 2; Floxuridine; Fluorouracil; Humans; Intercellular Signaling Peptides and Proteins; Kidney Neoplasms; Lung Neoplasms; Lymphokines; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Neoplasm Proteins; Neovascularization, Pathologic; Prodrugs; Prostheses and Implants; Recombinant Proteins; Sodium Oxybate; Stomach Neoplasms; Tegafur; Tumor Cells, Cultured; Uracil; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Xenograft Model Antitumor Assays | 2001 |
Overexpression of pyrimidine nucleoside phosphorylase enhances the sensitivity to 5'-deoxy-5-fluorouridine in tumour cells in vitro and in vivo.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Cell Survival; Colonic Neoplasms; Combined Modality Therapy; DNA, Complementary; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Floxuridine; Fluorouracil; Genetic Therapy; Humans; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Pentosyltransferases; Prodrugs; Pyrimidine Phosphorylases; Transfection; Tumor Cells, Cultured | 2002 |
Thymidine phosphorylase activity in renal cell carcinoma: relationship between histological parameters and chemosensitivity to fluorouracil-related drugs.
Topics: Antimetabolites, Antineoplastic; Carcinoma, Renal Cell; Floxuridine; Fluorouracil; Humans; Kidney; Kidney Neoplasms; Reference Values; Thymidine Phosphorylase | 2002 |
[A case of recurrent gastric cancer that responded dramatically to docetaxel and 5'-DFUR combination chemotherapy].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Docetaxel; Drug Administration Schedule; Floxuridine; Fluorouracil; Gastrectomy; Humans; Liver Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Invasiveness; Paclitaxel; Pancreatic Neoplasms; Stomach Neoplasms; Taxoids; Treatment Outcome | 2002 |
[A case of colon metastasis to the lung treated successfully with combined chemotherapy of CPT-11 and 5'-DFUR].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Drug Administration Schedule; Drug Combinations; Floxuridine; Fluorouracil; Humans; Irinotecan; Lung Neoplasms; Male; Middle Aged; Rectal Neoplasms; Tegafur; Uracil | 2002 |
Cytosolic and microsomal activation of doxifluridine and tegafur to produce 5-fluorouracil in human liver.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Cytosol; Floxuridine; Fluorouracil; Humans; In Vitro Techniques; Microsomes, Liver; Mixed Function Oxygenases; Steroid Hydroxylases; Tegafur; Thymidine Phosphorylase | 2002 |
Penetration of capecitabine and its metabolites into malignant and healthy tissue of patients with advanced breast cancer.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Deoxycytidine; Electrophoresis, Capillary; Extracellular Space; Floxuridine; Fluorouracil; Humans; Prodrugs; Skin Neoplasms; Tissue Distribution | 2002 |
Depression of phenytoin metabolic capacity by 5-fluorouracil and doxifluridine in rats.
Topics: Animals; Anticonvulsants; Antimetabolites, Antineoplastic; Cytochrome P-450 Enzyme System; Down-Regulation; Drug Interactions; Floxuridine; Fluorouracil; Male; Microsomes, Liver; Phenytoin; Rats; Rats, Sprague-Dawley | 2003 |
Preparation and characterization of chitosan microspheres containing doxifluridine.
Topics: Animals; Antimetabolites, Antineoplastic; Chemistry, Pharmaceutical; Chitin; Chitosan; Drug Implants; Floxuridine; Fluorouracil; Male; Mice; Microspheres; Rats; Rats, Wistar; Tegafur | 2003 |
ZD1839 (Iressa) modifies the activity of key enzymes linked to fluoropyrimidine activity: rational basis for a new combination therapy with capecitabine.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Cell Cycle; Cell Division; Cell Line, Tumor; Cell Survival; Deoxycytidine; DNA Primers; Floxuridine; Fluorouracil; Gefitinib; Head and Neck Neoplasms; Humans; Models, Chemical; Polymerase Chain Reaction; Pyrimidines; Quinazolines; RNA; RNA, Messenger; Time Factors; Transcription, Genetic | 2003 |
[A case of hepatic metastasis and local recurrence from rectal cancer responding to hepatic arterial infusion and systemic chemotherapy].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Drug Administration Schedule; Drug Combinations; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Irinotecan; Leucovorin; Liver Neoplasms; Male; Neoplasm Recurrence, Local; Rectal Neoplasms; Tegafur; Uracil | 2003 |
In vivo monitoring of capecitabine metabolism in human liver by 19fluorine magnetic resonance spectroscopy at 1.5 and 3 Tesla field strength.
Topics: Aged; Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Female; Floxuridine; Fluorine; Fluorouracil; Humans; Liver; Liver Neoplasms; Magnetic Resonance Spectroscopy; Male; Middle Aged; Prodrugs | 2003 |
Bioactivation of capecitabine in human liver: involvement of the cytosolic enzyme on 5'-deoxy-5-fluorocytidine formation.
Topics: Antimetabolites, Antineoplastic; Capecitabine; Cytosol; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Floxuridine; Fluorouracil; Humans; In Vitro Techniques; Microsomes, Liver; Prodrugs; Pyridines; Thymidine Phosphorylase | 2004 |
S-1-induced, prolonged complete regression of lung metastasis from gastric cancer refractory to 5'-DFUR: a case report with pharmacokinetic study.
Topics: Adenocarcinoma, Mucinous; Administration, Oral; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Drug Administration Schedule; Drug Combinations; Esophagectomy; Female; Floxuridine; Fluorouracil; Gastrectomy; Humans; Lung Neoplasms; Middle Aged; Oxonic Acid; Pyridines; Radiography, Thoracic; Remission Induction; Stomach Neoplasms; Tegafur; Tomography, X-Ray Computed | 2004 |
[Enhancement effect of interferon gamma on the sensitivity of RT4 bladder cancer cells to 5'-deoxy-5-fluorouridine,and 5-fluorouracil through up-regulation of PD-ECGF/TP].
Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Synergism; Floxuridine; Fluorouracil; Humans; Interferon-gamma; RNA, Messenger; Thymidine Phosphorylase; Up-Regulation; Urinary Bladder Neoplasms | 2004 |
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
Topics: Antineoplastic Agents; beta-Alanine; Cell Line, Tumor; Dihydrouracil Dehydrogenase (NADP); Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Foot Dermatoses; Hand Dermatoses; Humans; Inhibitory Concentration 50; Keratinocytes; Syndrome; Thymidine Phosphorylase | 2004 |
[A case of disseminated tumor from cecal cancer with survival for over 5 years after twice surgical resection and systemic chemotherapy].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoembryonic Antigen; Cecal Neoplasms; Combined Modality Therapy; Floxuridine; Fluorouracil; Humans; Irinotecan; Leucovorin; Male; Neoplasm Seeding; Peritoneal Neoplasms; Reoperation | 2004 |
[A case of long-term survival after chemo-radiation for postoperative local recurrence of rectal cancer].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Radiotherapy Dosage; Rectal Neoplasms | 2004 |
Comparative antitumor activity of 5-fluorouracil and 5'-deoxy-5-fluorouridine in combination with interferon-alpha in renal cell carcinoma cell lines.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Drug Screening Assays, Antitumor; Floxuridine; Fluorouracil; Humans; Interferon-alpha; Kidney Neoplasms; Tumor Cells, Cultured | 2004 |
[Successful combination therapy with 5'-DFUR and MPA for breast cancer with spinal and vertebral metastases].
Topics: Adenocarcinoma, Scirrhous; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Magnetic Resonance Imaging; Mastectomy; Medroxyprogesterone Acetate; Middle Aged; Remission Induction; Spinal Cord Neoplasms; Spinal Neoplasms | 2004 |
[Significance of tissue thymidine phosphorylase and dihydropyrimidine dehydrogenase activities in ovarian cancer].
Topics: 5'-Nucleotidase; Adenocarcinoma, Scirrhous; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Female; Floxuridine; Fluorouracil; Humans; Middle Aged; Ovarian Neoplasms; Survival Rate | 2004 |
Thymidine phosphorylase expression and efficacy of adjuvant doxifluridine in advanced colorectal cancer patients.
Topics: Administration, Oral; Aged; Antibodies, Monoclonal; Antimetabolites, Antineoplastic; Cell Differentiation; Cell Line, Tumor; Chemotherapy, Adjuvant; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Immunohistochemistry; Male; Middle Aged; Prognosis; Risk; Thymidine Phosphorylase; Time Factors; Treatment Outcome | 2005 |
The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites.
Topics: Adenosine Triphosphate; Antimetabolites, Antineoplastic; Apoptosis; Biological Transport; Cells, Cultured; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Floxuridine; Fluorouracil; Humans; Kidney; Multidrug Resistance-Associated Proteins; Phosphorylation; Thioguanine; Thymidylate Synthase | 2005 |
Effects of oral 5-fluorouracil drugs on hepatic fat content in patients with colon cancer.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Chi-Square Distribution; Colonic Neoplasms; Fatty Liver; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Retrospective Studies; Tegafur; Tomography, X-Ray Computed; Uracil | 2005 |
Correlations between antitumor activities of fluoropyrimidines and DPD activity in lung tumor xenografts.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Cell Line, Tumor; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Floxuridine; Fluorouracil; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Orotate Phosphoribosyltransferase; Oxonic Acid; Pyridines; Tegafur; Thymidine Phosphorylase; Treatment Outcome; Uracil; Xenograft Model Antitumor Assays | 2005 |
5-Fluorouracil concentration in blood, liver and tumor tissues and apoptosis of tumor cells after preoperative oral 5'-deoxy-5-fluorouridine in patients with hepatocellular carcinoma.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Carcinoma, Hepatocellular; Female; Floxuridine; Fluorouracil; Humans; Liver; Liver Neoplasms; Male; Middle Aged; Preoperative Care | 2005 |
Preferential inhibition of bone metastases by 5'-deoxy-5-fluorouridine and capecitabine in the 4T1/luc mouse breast cancer model.
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Capecitabine; Cell Line, Tumor; Deoxycytidine; Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Luciferases; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Time Factors; Transfection; Treatment Outcome | 2005 |
[Experience with capecitabine in patients with anthracycline and/or taxane-resistant recurrent breast cancer].
Topics: Administration, Oral; Anthracyclines; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Deoxycytidine; Drug Resistance, Neoplasm; Female; Floxuridine; Fluorouracil; Humans; Middle Aged; Taxoids | 2005 |
Simultaneous determination of capecitabine and its metabolites by HPLC and mass spectrometry for preclinical and clinical studies.
Topics: Animals; Capecitabine; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Deoxycytidine; Drug Stability; Floxuridine; Fluorouracil; Humans; Liver; Mice; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2005 |
[Case report--postoperative continuous intraarterial infusion of small doses of 5-FU successfully controlled residual tumor and liver metastasis of stage IV gastric cancer].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Disease-Free Survival; Doxorubicin; Drug Combinations; Floxuridine; Fluorouracil; Gastrectomy; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Lymph Node Excision; Lymph Nodes; Lymphatic Metastasis; Male; Methotrexate; Mitomycin; Neoplasm Staging; Picibanil; Proteoglycans; Stomach Neoplasms; Tegafur; Uracil | 2005 |
[Pharmacokinetic comparison of capecitabine and 5'-deoxy-5-fluorouridine (doxifluridine; 5'-DFUR)].
Topics: Antimetabolites, Antineoplastic; Area Under Curve; Breast Neoplasms; Capecitabine; Clinical Trials, Phase II as Topic; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Prodrugs | 2005 |
Upregulation of thymidine phosphorylase in rectal cancer tissues by mitomycin C.
Topics: Adult; Aged; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chemotherapy, Adjuvant; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Disease-Free Survival; Female; Floxuridine; Fluorouracil; Humans; Immunohistochemistry; Male; Middle Aged; Mitomycin; Rectal Neoplasms; Thymidine Phosphorylase; Up-Regulation | 2006 |
Modulation of uridine phosphorylase gene expression by tumor necrosis factor-alpha enhances the antiproliferative activity of the capecitabine intermediate 5'-deoxy-5-fluorouridine in breast cancer cells.
Topics: Animals; Base Sequence; Capecitabine; Deoxycytidine; DNA Primers; Drug Synergism; Electrophoretic Mobility Shift Assay; Floxuridine; Fluorouracil; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Mammary Neoplasms, Experimental; Mice; NF-kappa B; Tumor Necrosis Factor-alpha; Uridine Phosphorylase | 2006 |
Induction of thymidine phosphorylase expression by AZT contributes to enhancement of 5'-DFUR cytotoxicity.
Topics: Antimetabolites; Cell Survival; Drug Synergism; Floxuridine; Fluorouracil; Humans; Thymidine Phosphorylase; Transfection; U937 Cells; Zidovudine | 2006 |
The role of thymidine phosphorylase and uridine phosphorylase in (fluoro)pyrimidine metabolism in peripheral blood mononuclear cells.
Topics: Cells, Cultured; Floxuridine; Fluorouracil; Humans; Inhibitory Concentration 50; Leukocytes, Mononuclear; Pyrimidines; RNA; Substrate Specificity; Thymidine; Thymidine Phosphorylase; Uridine Phosphorylase | 2006 |
Relationship between AUC of 5'-DFUR and toxicity of capecitabine, fluoropyrimidine carbamate analogs, and 5'-DFUR in monkeys, mice, and rats.
Topics: Animals; Antimetabolites, Antineoplastic; Area Under Curve; Capecitabine; Carbamates; Deoxycytidine; Floxuridine; Fluorouracil; Intestines; Macaca fascicularis; Male; Mice; Rats; Rats, Sprague-Dawley | 2006 |
Irinotecan cytotoxicity does not necessarily depend on the UGT1A1 polymorphism but on fluoropyrimidine: a molecular case report.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Glucuronosyltransferase; Humans; Irinotecan; Polymorphism, Genetic | 2006 |
[Effectiveness of preoperative chemoradiotherapy for advanced rectal cancer].
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Staging; Pelvis; Preoperative Care; Radiotherapy Dosage; Radiotherapy, Adjuvant; Rectal Neoplasms; Rectum; Survival Rate | 2006 |
Rapid and simultaneous determination of capecitabine and its metabolites in mouse plasma, mouse serum, and in rabbit bile by high-performance liquid chromatography.
Topics: Animals; Bile; Calibration; Capecitabine; Chromatography, High Pressure Liquid; Deoxycytidine; Floxuridine; Fluorouracil; Mice; Plasma; Rabbits; Reproducibility of Results; Serum | 2007 |
The Hollow Fibre Assay as a model for in vivo pharmacodynamics of fluoropyrimidines in colon cancer cells.
Topics: Administration, Oral; Animals; Apoptosis; Capecitabine; Cell Cycle; Cell Line, Tumor; Colonic Neoplasms; Deoxycytidine; Drug Combinations; Drug Synergism; Enzyme Inhibitors; Flow Cytometry; Floxuridine; Fluorouracil; Humans; Mice; Mice, Inbred BALB C; Pyrrolidines; Sensitivity and Specificity; Thymidine Phosphorylase; Thymine; Treatment Outcome; Trifluridine; Tumor Cells, Cultured; Uracil; Xenograft Model Antitumor Assays | 2007 |
[A case of colon cancer liver metastases treated by combined therapies].
Topics: Antineoplastic Combined Chemotherapy Protocols; Catheter Ablation; Chemotherapy, Adjuvant; Colon, Sigmoid; Combined Modality Therapy; Floxuridine; Fluorouracil; Hepatectomy; Humans; Jaundice, Obstructive; Leucovorin; Liver Neoplasms; Lymph Node Excision; Male; Middle Aged; Sigmoid Neoplasms; Stents; Tegafur | 2006 |
[Evaluation of combination therapy of high-dose toremifene and oral chemotherapy].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Cyclophosphamide; Deoxycytidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Female; Floxuridine; Fluorouracil; Humans; Liver Neoplasms; Lung Neoplasms; Lymph Nodes; Lymphatic Metastasis; Middle Aged; Neoplasm Recurrence, Local; Oxonic Acid; Quality of Life; Skin Neoplasms; Tegafur; Toremifene | 2007 |
Development and characterization of a model of liver metastasis using human colon cancer HCT-116 cells.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Adhesion; Cell Line, Tumor; Collagen Type II; Colonic Neoplasms; Female; Fibronectins; Floxuridine; Fluorouracil; Humans; Irinotecan; Laminin; Liver Neoplasms; Mice; Mice, Inbred C57BL; Mice, Nude; Models, Biological; Neoplasm Metastasis; Paclitaxel | 2007 |
Immunochemotherapy with PSK and fluoropyrimidines improves long-term prognosis for curatively resected colorectal cancer.
Topics: Aged; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Combined Modality Therapy; Drug Combinations; Female; Floxuridine; Fluorouracil; Humans; Immunotherapy; Kaplan-Meier Estimate; Male; Middle Aged; Prognosis; Proportional Hazards Models; Proteoglycans; Retrospective Studies; Tegafur; Uracil | 2008 |
Simultaneous determination of doxifluridine and 5-fluorouracil in monkey serum by high performance liquid chromatography with tandem mass spectrometry.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Chromatography, High Pressure Liquid; Drug Stability; Floxuridine; Fluorouracil; Linear Models; Macaca fascicularis; Male; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2008 |
Postoperative chemotherapy after neoadjuvant chemoradiation and surgery for rectal cancer: is it essential for patients with ypT0-2N0?
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Floxuridine; Fluorouracil; Follow-Up Studies; Humans; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Rectal Neoplasms; Retrospective Studies; Tegafur; Uracil | 2009 |
A new, validated HPLC-MS/MS method for the simultaneous determination of the anti-cancer agent capecitabine and its metabolites: 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, 5-fluorouracil and 5-fluorodihydrouracil, in human plasma.
Topics: 1-Propanol; Acetonitriles; Antimetabolites, Antineoplastic; Capecitabine; Chemical Precipitation; Chromatography, High Pressure Liquid; Deoxycytidine; Drug Stability; Floxuridine; Fluorouracil; Furans; Humans; Linear Models; Pyrimidines; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Trichloroacetic Acid; Uracil; Vidarabine | 2010 |
Increased anticoagulant activity of warfarin used in combination with doxifluridine.
Topics: Administration, Oral; Aged; Anticoagulants; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Humans; International Normalized Ratio; Warfarin | 2010 |
Plasma disposition of capecitabine (CCB) and its metabolites 5'-deoxy-5-fluorocytidine (5'-DFCR) and 5'-deoxy-5-fluorouracil (5'-DFUR) with two different capecitabine/oxaliplatin dosage regimens.
Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Floxuridine; Fluorouracil; Humans; Organoplatinum Compounds; Oxaliplatin | 2010 |
Vorinostat synergises with capecitabine through upregulation of thymidine phosphorylase.
Topics: Animals; Antineoplastic Agents; Apoptosis; Capecitabine; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Drug Synergism; Female; Floxuridine; Fluorouracil; Gene Expression Regulation, Enzymologic; Histone Deacetylase Inhibitors; Hydroxamic Acids; Mice; Mice, Inbred BALB C; Thymidine Phosphorylase; Thymidylate Synthase; Up-Regulation; Vorinostat; Xenograft Model Antitumor Assays | 2010 |
[Improved sensitivity of gastric carcinoma cells to fluorouracil-related drugs by transfection of thymidine phosphorylase gene].
Topics: Antimetabolites, Antineoplastic; Capecitabine; Cell Line, Tumor; Deoxycytidine; Floxuridine; Fluorouracil; Humans; Plasmids; Recombinant Proteins; RNA, Messenger; Sensitivity and Specificity; Stomach Neoplasms; Thymidine Phosphorylase; Transfection | 2011 |
Inhibition of EGFR phosphorylation in a panel of human breast cancer cells correlates with synergistic interactions between gefitinib and 5'-DFUR, the bioactive metabolite of Xeloda.
Topics: Antineoplastic Agents; Breast Neoplasms; Capecitabine; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deoxycytidine; Drug Synergism; ErbB Receptors; Female; Floxuridine; Fluorouracil; Gefitinib; Gene Expression Regulation, Enzymologic; Humans; Inhibitory Concentration 50; Methotrexate; Phosphorylation; Protein Processing, Post-Translational; Quinazolines; Thymidine Phosphorylase; Thymidylate Synthase | 2012 |
Reliability of tumor primary cultures as a model for drug response prediction: expression profiles comparison of tissues versus primary cultures from colorectal cancer patients.
Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Cisplatin; Colorectal Neoplasms; Deoxycytidine; Down-Regulation; Doxorubicin; Etoposide; Floxuridine; Fluorescent Antibody Technique; Fluorouracil; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genomic Instability; Humans; Irinotecan; Metaphase; Paclitaxel; Polymerase Chain Reaction; Predictive Value of Tests; Protein Array Analysis; Reproducibility of Results; Tegafur; Tissue Array Analysis; Tumor Cells, Cultured; Up-Regulation; Uracil | 2012 |
The effect of chemotherapy or radiotherapy on thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in cancer of the uterine cervix.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Capecitabine; Carcinoma, Squamous Cell; Chemoradiotherapy; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Female; Floxuridine; Fluorouracil; Humans; Ifosfamide; Middle Aged; Neoadjuvant Therapy; Organoplatinum Compounds; Peplomycin; Thymidine Phosphorylase; Uterine Cervical Neoplasms | 2012 |
Aquaporin 3 (AQP3) participates in the cytotoxic response to nucleoside-derived drugs.
Topics: Antineoplastic Agents; Apoptosis; Aquaporin 3; Blotting, Western; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Size; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Deoxycytidine; Dose-Response Relationship, Drug; fas Receptor; Floxuridine; Fluorouracil; Gemcitabine; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; MCF-7 Cells; Nucleosides; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Up-Regulation | 2012 |
Predictive markers of capecitabine sensitivity identified from the expression profile of pyrimidine nucleoside-metabolizing enzymes.
Topics: Animals; Antimetabolites, Antineoplastic; Capecitabine; Cell Line, Tumor; Cytidine Deaminase; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Floxuridine; Fluorouracil; Mice; Mice, Nude; Neoplasms; Nucleoside-Phosphate Kinase; Orotate Phosphoribosyltransferase; Ribonucleotide Reductases; RNA, Messenger; Thymidine Kinase; Thymidine Phosphorylase; Thymidylate Synthase; Uridine Kinase; Uridine Phosphorylase | 2013 |
Pharmacokinetic analysis of doxifluridine and its metabolites, 5-fluorouracil and 5-fluorouridine, after oral administration in beagle dogs.
Topics: Administration, Oral; Algorithms; Animals; Antimetabolites, Antineoplastic; Area Under Curve; Capsules; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Dogs; Floxuridine; Fluorouracil; Indicators and Reagents; Mass Spectrometry; Tandem Mass Spectrometry; Uridine | 2013 |
CD49f(high) cells retain sphere-forming and tumor-initiating activities in human gastric tumors.
Topics: Animals; Antineoplastic Agents; Biomarkers, Tumor; Doxorubicin; Drug Resistance, Neoplasm; Floxuridine; Fluorouracil; Humans; Inhibitory Concentration 50; Integrin alpha6; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Neoplasm Transplantation; Neoplastic Stem Cells; Spheroids, Cellular; Stomach Neoplasms; Tumor Cells, Cultured | 2013 |
Protein-bound polysaccharide-K augments the anticancer effect of fluoropyrimidine derivatives possibly by lowering dihydropyrimidine dehydrogenase expression in gastrointestinal cancers.
Topics: Antineoplastic Agents; Cell Proliferation; Colonic Neoplasms; Dihydrouracil Dehydrogenase (NADP); Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Leukocytes, Mononuclear; Polysaccharides; Protein Binding; Thymidylate Synthase | 2013 |
Comparative in vitro evaluation of transportability and toxicity of capecitabine and its metabolites in cells derived from normal human kidney and renal cancers.
Topics: Antimetabolites, Antineoplastic; Biological Transport; Biotransformation; Capecitabine; Cell Line, Tumor; Deoxycytidine; Equilibrative Nucleoside Transporter 1; Equilibrative-Nucleoside Transporter 2; Floxuridine; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Hydrogen-Ion Concentration; Interferon-alpha; Kidney Tubules, Proximal; Kinetics; Nucleosides; Signal Transduction; Thymidine Phosphorylase | 2013 |
[Enhanced anticancer effects of 5'-DFUR on colorectal cancer cell lines SW480 and LOVO by transfection with thymidine phosphorylase cDNA].
Topics: Cell Line, Tumor; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; Thymidine Phosphorylase; Transcription, Genetic; Transfection | 2013 |
Impact of co-administered drugs on drug monitoring of capecitabine in patients with advanced colorectal cancer.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Deoxycytidine; Drug Administration Schedule; Drug Interactions; Drug Monitoring; Floxuridine; Fluorouracil; Humans; Pantoprazole; Proton Pump Inhibitors | 2014 |
Clinical pharmacokinetics of capecitabine and its metabolites in combination with the monoclonal antibody bevacizumab.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged | 2014 |
[Transfection of thymidine phosphorylase cDNA with lentiviral vector enhances the anticancer effect of 5'-deoxy-5-fluorouridine on colorectal cancer cell lines HT29 and LS174T].
Topics: Antineoplastic Agents; Cell Line; Cell Line, Tumor; Colorectal Neoplasms; DNA, Complementary; Floxuridine; Fluorouracil; Genetic Vectors; HT29 Cells; Humans; RNA, Messenger; Thymidine Phosphorylase; Transfection | 2015 |
Circadian variations in the pharmacokinetics of capecitabine and its metabolites in rats.
Topics: Animals; Antimetabolites, Antineoplastic; Capecitabine; Circadian Rhythm; Deoxycytidine; Floxuridine; Fluorouracil; Male; Prodrugs; Rats, Wistar | 2018 |
Rabeprazole intake does not affect systemic exposure to capecitabine and its metabolites, 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, and 5-fluorouracil.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Capecitabine; Cell Proliferation; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Deoxycytidine; Drug Interactions; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Prospective Studies; Proton Pump Inhibitors; Rabeprazole | 2019 |
Development of a UPLC-MS/MS Assay for the Quantitative Determination of Capecitabine, 5'-deoxy-5-fluorocytidine (5'-dFCR), 5'-deoxy-5-fluorouridine (5'-dFUR), 5'-fluorouracil (5-FU), and α-fluoro-β-alanine (FBAL).
Topics: beta-Alanine; Capecitabine; Chromatography, High Pressure Liquid; Chromatography, Liquid; Fluorouracil; Humans; Lithium; Prodrugs; Tandem Mass Spectrometry | 2023 |