fluorouracil has been researched along with curcumin in 105 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (8.57) | 29.6817 |
| 2010's | 63 (60.00) | 24.3611 |
| 2020's | 33 (31.43) | 2.80 |
| Authors | Studies |
|---|---|
| Barresi, V; Cardullo, N; Condorelli, D; Musso, N; Spatafora, C; Tringali, C | 1 |
| Bala, V; Chaturvedi, S; Gupta, G; Gupta, S; Konwar, R; Maikhuri, JP; Mandalapu, D; Saini, KS; Sharma, V; Sharma, VL; Thakur, S; Wahajuddin, M; Yaseen Malik, M | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Chen, C; Fu, L; Hu, Y; Li, S; Liu, Z; Ma, Y; Qiu, C; Wang, N; Wu, K; Yang, K; Zhang, X; Zhang, Y; Zhou, Y; Zhu, H | 1 |
| Addala, E; Bandy, B; Das, S; Das, U; Dimmock, JR; Karki, SS; Rafiei, H | 1 |
| Behera, C; Chanda, D; Fatima, K; Gupta, AK; Hasanain, M; Khwaja, S; Kour, A; Luqman, S; Mondhe, DM; Negi, AS; Sarkar, J; Shanker, K; Singh, A | 1 |
| Chen, L; Cheng, D; Li, Q; Qiu, P; Sirirak, T; Wang, J; Weng, B; Wu, J; Zhou, Y | 1 |
| Capito, JE; El-Manawaty, MA; George, RF; Girgis, AS; Panda, SS; Salman, A; Samir, A; Thomas, SJ | 1 |
| Arya, GC; Jaitak, V; Kaur, K | 1 |
| Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
| Jung, KO; Kim, HJ; Koo, JY; Park, KY | 1 |
| Chung, KO; Kim, JY; Kim, KH; Koo, JY; Nam, JH; Park, HY; Park, JE; Park, KY; Park, MI | 1 |
| Du, B; Jiang, L; Xia, Q; Zhong, L | 1 |
| Majumdar, AP; Patel, BB; Qazi, S; Rishi, AK; Sengupta, R; Vachhani, H; Yu, Y | 1 |
| Liu, HT; Song, M; Tian, F; Xu, PR; Xue, LX | 1 |
| Ghosh, SS; Gopinath, P | 1 |
| Saif, MW | 1 |
| Aggarwal, BB; Anand, P; Deorukhkar, A; Diagaradjane, P; Gelovani, J; Guha, S; Harikumar, KB; Krishnan, S; Kunnumakkara, AB; Kuzhuvelil, HB | 1 |
| Majumdar, AP; Patel, BB | 1 |
| Elliott, AA; Gupta, D; Majumdar, AP; Patel, BB; Sengupta, V; Yu, Y | 1 |
| Li, Y; Paxton, JW; Reid, G; Revalde, JL | 1 |
| Jiang, Y; Tian, F; Tian, W; Zhang, C; Zhang, X | 1 |
| Cao, SQ; Yang, SL; Yin, TY | 1 |
| Srimuangwong, K; Suksamrarn, A; Tocharus, C; Tocharus, J; Yoysungnoen Chintana, P | 1 |
| Fan, T; Jiang, Y; Tian, F; Zhang, X; Zhang, Y | 1 |
| Chintana, PY; Srimuangwong, K; Suksamrarn, A; Tocharus, C; Tocharus, J | 1 |
| Anto, RJ; Antony, J; Bevin, A; Nair, HH; Narayanan, SS; Puliyappadamba, VT; Saikia, M; Vinod, BS | 1 |
| Busch, F; Goel, A; Lueders, C; Mobasheri, A; Shakibaei, M; Shayan, P | 1 |
| Angel-Morales, G; Jutooru, I; Mertens-Talcott, SU; Noratto, GD; Safe, S | 1 |
| Gao, B; Liu, H; Wang, S; Wu, X; Xiao, Y; Xie, Q; Zhu, R | 1 |
| Wang, WM; You, T; Zheng, ZQ; Zhou, X | 1 |
| Fu, T; Gu, J; Guo, Y; Jin, H; Lai, Y; Wang, L; Wang, X; Wang, Y; Yao, Q; Ye, X | 1 |
| Buhrmann, C; Goel, A; Kraehe, P; Lueders, C; Shakibaei, M; Shayan, P | 2 |
| Ferguson, JE; Orlando, RA | 1 |
| Balasubramanian, S; Girija, AR; Iwai, S; Kizhikkilot, V; Maekawa, T; Nagaoka, Y; Nair, SD; Suzuki, M; Yoshida, Y | 1 |
| Anitha, A; Chennazhi, KP; Jayakumar, R; Lakshmanan, VK; Sreeranganathan, M | 1 |
| Anitha, A; Chennazhi, KP; Deepa, N; Jayakumar, R; Lakshmanan, VK | 1 |
| Ferruzzi, L; Fimognari, C; Turrini, E | 1 |
| Chowdhry, B; Douroumis, D; Klepetsanis, P; Prausnitz, MR; Scoutaris, N; Uddin, MJ | 1 |
| Boland, CR; Buhrmann, C; Goel, A; Jascur, T; Komarova, NL; Okugawa, Y; Shakibaei, M; Toden, S; Wodarz, D | 1 |
| Iqbal, Z; Khuroo, T; Talegaonkar, S; Verma, D | 1 |
| Berry, DP; Brown, K; Howells, LM; Irving, GR; Iwuji, CO; Morgan, B; Steward, WP; Thomas, A | 1 |
| Buhrmann, C; Goel, A; Kraehe, P; Popper, B; Shakibaei, M; Shayan, P | 1 |
| Berry, DP; Brown, K; Cai, H; Dennison, A; Garcea, G; Greaves, P; Griffin-Teal, N; Higgins, JA; Howells, LM; Irving, G; Iwuji, C; James, MI; Karmokar, A; Lloyd, DM; Metcalfe, M; Morgan, B; Patel, SR; Steward, WP; Thomas, A | 1 |
| Chen, D; Hu, H; Huang, Z; Qiao, M; Sun, Y; Zhang, J; Zhao, X; Zhou, J | 1 |
| Bharti, AC; Dwivedi, M; Mahata, S; Mehrotra, R; Misra, SP; Misra, V; Pandey, A; Tripathi, SC; Vishnoi, K | 1 |
| Krishnan, UM; Sethuraman, S; Sivanantham, B | 1 |
| Ahmed, SH; Elmalahy, MH; Masloub, SM; Mohamed, WS; Sabry, D | 1 |
| Li, P; Tu, Y; Wang, W; You, T; Zhang, Y; Zheng, Z; Zhou, X | 1 |
| Geetha, P; Gopi Mohan, C; Jayakumar, R; Sivaram, AJ | 1 |
| Kai, Y; Kimura, M; Narita, M; Oguchi, A; Saito, T; Sakai, H; Sato, F; Sato, K; Tabata, S; Yaegashi, M; Yumoto, T | 1 |
| Chen, D; Chen, W; Cheng, X; Dai, F; Liu, Q; Wang, S; Zhang, M; Zhao, H | 1 |
| Anirudhan, TS; Bino, SJ; Nair, AS | 1 |
| Alonso, V; Asensio, E; Camps, J; Castells, A; Codony-Servat, J; Cuatrecasas, M; Escudero, P; Feliu, J; Fernández-Martos, C; Gaba, L; Gallego, J; García-Albéniz, X; Horndler, C; Jares, P; Marín-Aguilera, M; Martín-Richard, M; Martínez-Balibrea, E; Martínez-Cardús, A; Maurel, J; Méndez, JC; Méndez, M; Montironi, C; Prat, A; Reig, O; Rojo, F; Rosell, R; Rubini, M; Salud, A; Victoria, I | 1 |
| Avan, A; Ferns, GA; Ghayour-Mobarhan, M; Hassanian, SM; Jalili-Nik, M; Moussavi, S; Soltani, A | 1 |
| Cao, S; Wei, Y; Yang, P; Zhao, L | 1 |
| Chen, HF; Chen, XF; Jia, T; Lai, ZL; Sun, WQ; Wang, A; Zhang, J; Zhang, M; Zhang, P; Zhao, Z; Zhu, XM | 1 |
| Afsharmoghadam, N; Alavi, SA; Haghighatian, Z; Mazdak, H; Mehrabi Koushki, R; Mirkheshti, N | 1 |
| Fung, KP; Lau, CB; Li, M; Tsui, SK; Yue, GG | 1 |
| Chen, YY; He, LJ; Jia, YW; Liu, DF; Liu, XP; Miao, DD; Shen, J; Ye, HZ; Zhang, C; Zhang, SP; Zhu, YB | 1 |
| Gao, X; Ji, Y; Jian, X; Li, Z; Liu, Z; Ni, W; Sun, S; Wu, L | 1 |
| Chen, Y; Han, Z; He, X; Kaplan, DL; Lan, P; Li, G; Li, Y; Wang, X; Wang, Y; Xie, X; Zheng, B; Zheng, X; Zheng, Z | 1 |
| Geusz, ME; Jamasbi, RJ; Pendleton, EG | 1 |
| Amanlou, M; Bigdeli, B; Dehghani, S; Goliaei, B; Hosseini, M; Khoobi, M; Lotfabadi, A; Naeimi, H; Nejadshafiee, V; Nezamtaheri, MS; Sadighi, A; Sharifzadeh, M | 1 |
| Cheraghpour, M; Hosseini, SA; Zand, H | 1 |
| Barber, S; Brown, K; Foreman, N; Gescher, A; Griffin-Teall, N; Howells, LM; Irving, GRB; Iwuji, COO; Morgan, B; Patel, SR; Sidat, Z; Singh, R; Steward, WP; Thomas, AL; Walter, H | 1 |
| Doğanlar, O; Doğanlar, ZB; Güçlü, O; Yüksel, V | 1 |
| Amiri Moghadam, S; ArefNezhad, R; Avan, A; Banikazemi, Z; Ghasemi, F; Khanbabaei, H; Mirzaei, H; Pourhanifeh, MH; Sahebkar, A; Shafiee, M; Shamshirian, A | 1 |
| Karthika, C; Sureshkumar, R | 1 |
| Epifano, F; Fiorito, S; Genovese, S; Majumdar, APN; Nangia-Makker, P; Preziuso, F; Slater, J | 1 |
| Agrawal, G; Deeba, F; Gopinath, P; Kulshreshtha, A; Kumar, A; Kumar, B; Negi, YS; Priyadarshi, R | 1 |
| Booth, L; Dent, P; Hancock, JF; Poklepovic, A; Roberts, JL | 1 |
| Jia, Y; Peng, L; Zhang, C; Zhang, M; Zhang, Z; Zhou, Y | 1 |
| Lu, Y; Yao, Q; Zhang, B; Zhang, R; Zhang, X | 1 |
| He, B; Hu, D; Li, R; Liao, W; Liu, Q; Peng, X; Wang, Q; Xiang, L; Zhao, G | 1 |
| Chen, YB; Wang, X; Wang, XY; Xu, L; Yao, QH | 1 |
| Lin, J; Shao, Y; Song, F; Yang, X; Zheng, X | 1 |
| Gelen, V; Kükürt, A; Şengül, E; Senturk, E; Tekin, S; Yıldırım, S | 1 |
| Cardona-G, W; Hernández, C; Herrera-R, A; Moreno, G | 1 |
| Abdel-Daim, MM; Akhtar, MF; Akter, R; Albadrani, GM; Hari, B; Karthika, C; Najda, A; Rahman, MH; Sayed, AA | 1 |
| Cai, BY; Lu, Y; Wang, XY; Wang, YJ; Xu, L; Yao, QH; Zhang, B | 1 |
| Han, Y; Jin, M; Kong, L; Zhang, S | 1 |
| Abugomaa, A; Ayame, H; Elbadawy, M; Hayashi, K; Hayashi, SM; Hazama, S; Ishihara, Y; Kaneda, M; Nagano, H; Nakajima, M; Sasaki, K; Shibutani, M; Shinohara, Y; Suzuki, N; Takenouchi, H; Tsunedomi, R; Usui, T; Yamawaki, H | 1 |
| Chen, L; Fang, S; Kong, B; Li, G; Li, Y; Shao, X; Tong, Q; Wang, Y; Xie, X; Yang, J; Yu, H; Zhang, J | 1 |
| Wang, X; Zhu, J | 1 |
| Ghasemi, F; Sahebkar, A; Ziasarabi, P | 1 |
| Ashraf, GM; Karthika, C; Rahman, MH; Sajini, DV; Sureshkumar, R | 1 |
| Choi, KS; Ham, IH; Hur, H; Jeong, HY; Kim, TH; Kim, TM; Lee, D; Oh, HJ; Wang, L; Woo, J | 1 |
| Butnariu, M; Calina, D; Cho, WC; Hossain, R; Islam, MS; Islam, MT; Khalipha, ABR; Khan, RA; Martorell, M; Ray, P; Sarkar, C; Sharifi-Rad, J; Umbetova, A | 1 |
| Boddu, A; Lai, WF; Obireddy, SR; Rao, KSVK; Zhang, D | 1 |
| Ene, AG; Ficai, A; Ficai, D; Vladu, AF | 1 |
| Bakr, EA; Gaber, M; Saad, DR; Salahuddin, N | 1 |
| Abolhassani, H; Hashemi-Najafabadi, S; Shojaosadati, SA; Zaer, M | 1 |
| Brockmueller, A; Büsselberg, D; Kubatka, P; Mazurakova, A; Samuel, SM; Shakibaei, M | 1 |
| Namazi, H; Pooresmaeil, M | 1 |
| Lawson, S; Newport, K; Pederneira, N; Rezaei, F; Rownaghi, AA | 1 |
| Guo, L; Guo, YP; Guo, YR; Liu, YS; Peng, C; Song, JW; Yuan, MH; Zhong, WX | 1 |
| Ardakani, MT; Baneshi, M; Bardania, H; Barmak, MJ; Jafari, F; Mahmoudi, R; Safari, F | 1 |
| Aggarwal, BB; Gupta, SC; Kim, JH; Park, B; Yadav, VR | 1 |
| Lu, B; Ma, ZJ; Shen, Y; Zhang, S | 1 |
| Cai, LJ; Lu, B; Meng, LN; Song, SP | 1 |
| Abd Malek, SN; Abdulla, MA; Al-Henhena, N; Awang, K; Hasanpourghadi, M; Kunasegaran, T; Looi, CY; Moghadamtousi, SZ; Mohamed, Z; Rouhollahi, E | 1 |
| Batista, AC; da Silva, ACG; de Ávila, RI; de Oliveira, CMA; Dos Santos Filho, EX; Lima, EM; Marreto, RN; Mendonça, EF; Valadares, MC | 1 |
| Batista, AC; Curra, M; de Oliveira, AC; Marreto, RN; Martins, MAT; Martins, MD; Schmidt, TR; Valadares, MC; Wagner, VP | 1 |
8 review(s) available for fluorouracil and curcumin
| Article | Year |
|---|---|
Isoxazole derivatives as anticancer agent: A review on synthetic strategies, mechanism of action and SAR studies.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Proliferation; Drug Screening Assays, Antitumor; Female; Humans; Isoxazoles | 2021 |
Synergistic role of curcumin with current therapeutics in colorectal cancer: minireview.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Colorectal Neoplasms; Curcumin; Deoxycytidine; Fluorouracil; Gastrointestinal Neoplasms; Gemcitabine; Humans; Organoplatinum Compounds; Oxaliplatin; Treatment Outcome | 2009 |
Natural compounds to overcome cancer chemoresistance: toxicological and clinical issues.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Curcumin; Drug Resistance, Neoplasm; Fluorouracil; Humans; Isothiocyanates; Neoplasms; Platinum Compounds; Signal Transduction; Sulfoxides | 2014 |
Current status and future prospective of Curcumin as a potential therapeutic agent in the treatment of colorectal cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Curcumin; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Organoplatinum Compounds | 2018 |
The combination of curcumin and 5-fluorouracil in cancer therapy.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Curcumin; Fluorouracil; Humans; Neoplasms | 2018 |
Multiple strategies with the synergistic approach for addressing colorectal cancer.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Colorectal Neoplasms; Curcumin; Drug Synergism; Fluorouracil; Humans; Lipids; Nanoparticles; Prodrugs | 2021 |
Combination Therapy Using Polyphenols: An Efficient Way to Improve Antitumoral Activity and Reduce Resistance.
Topics: Anti-Bacterial Agents; Antineoplastic Agents; beta Catenin; Breast Neoplasms; Catechin; Curcumin; Cytostatic Agents; Doxorubicin; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Female; Fluorouracil; Humans; Liver Neoplasms; Polyphenols; Receptors, Estrogen; Resveratrol | 2022 |
Curcumin, calebin A and chemosensitization: How are they linked to colorectal cancer?
Topics: Cell Line, Tumor; Cisplatin; Colorectal Neoplasms; Curcumin; Cytostatic Agents; Drug Resistance, Neoplasm; Fluorouracil; Humans; Irinotecan; Oxaliplatin | 2023 |
3 trial(s) available for fluorouracil and curcumin
| Article | Year |
|---|---|
Combining curcumin (C3-complex, Sabinsa) with standard care FOLFOX chemotherapy in patients with inoperable colorectal cancer (CUFOX): study protocol for a randomised control trial.
Topics: Administration, Oral; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Clinical Protocols; Colorectal Neoplasms; Curcumin; Disease Progression; Disease-Free Survival; Drug Administration Schedule; England; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Organoplatinum Compounds; Oxaliplatin; Research Design; Time Factors; Treatment Outcome | 2015 |
Curcumin inhibits cancer stem cell phenotypes in ex vivo models of colorectal liver metastases, and is clinically safe and tolerable in combination with FOLFOX chemotherapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Colorectal Neoplasms; Curcumin; Dose-Response Relationship, Drug; Fluorouracil; Heterografts; Humans; Leucovorin; Liver Neoplasms; Mice; Mice, Inbred NOD; Mice, SCID; Neoplastic Stem Cells; Organoplatinum Compounds; Oxaliplatin; Spheroids, Cellular | 2015 |
Curcumin Combined with FOLFOX Chemotherapy Is Safe and Tolerable in Patients with Metastatic Colorectal Cancer in a Randomized Phase IIa Trial.
Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Curcumin; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Organoplatinum Compounds; Treatment Outcome | 2019 |
94 other study(ies) available for fluorouracil and curcumin
| Article | Year |
|---|---|
Resveratrol-Related Polymethoxystilbene Glycosides: Synthesis, Antiproliferative Activity, and Glycosidase Inhibition.
Topics: alpha-Glucosidases; Antineoplastic Agents; Caco-2 Cells; Cell Proliferation; Fluorouracil; Glycoside Hydrolase Inhibitors; Glycosides; Humans; Molecular Structure; Resveratrol; Stereoisomerism; Stilbenes | 2015 |
Synthesis and biological evaluation of some novel triazole hybrids of curcumin mimics and their selective anticancer activity against breast and prostate cancer cell lines.
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Click Chemistry; Curcumin; Down-Regulation; Drug Screening Assays, Antitumor; Female; Half-Life; HEK293 Cells; Humans; Male; Membrane Potential, Mitochondrial; Proliferating Cell Nuclear Antigen; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Triazoles | 2016 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Synthesis and biological evaluation of allylated mono-carbonyl analogues of curcumin (MACs) as anti-cancer agents for cholangiocarcinoma.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cholangiocarcinoma; Curcumin; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Structure-Activity Relationship | 2016 |
3,5-Bis(3-dimethylaminomethyl-4-hydroxybenzylidene)-4-piperidone and related compounds induce glutathione oxidation and mitochondria-mediated cell death in HCT-116 colon cancer cells.
Topics: Apoptosis; Cell Line; Colonic Neoplasms; Curcumin; Glutathione; HCT116 Cells; Humans; Membrane Potential, Mitochondrial; Mitochondria; Oxidation-Reduction; Piperidones; Reactive Oxygen Species; Superoxides | 2017 |
Antiproliferative efficacy of curcumin mimics through microtubule destabilization.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Curcumin; Drug Screening Assays, Antitumor; Female; Humans; Male; Mice; Microtubules; Neoplasms | 2018 |
Design, synthesis, anti-lung cancer activity, and chemosensitization of tumor-selective MCACs based on ROS-mediated JNK pathway activation and NF-κB pathway inhibition.
Topics: A549 Cells; Antineoplastic Agents; Curcumin; Drug Design; Humans; Lung Neoplasms; MAP Kinase Signaling System; NF-kappa B; Reactive Oxygen Species | 2018 |
Synthesis, pharmacological profile and 2D-QSAR studies of curcumin-amino acid conjugates as potential drug candidates.
Topics: Amino Acids; Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Candida albicans; Carrageenan; Cell Proliferation; Curcumin; Dose-Response Relationship, Drug; Edema; Mice; Microbial Sensitivity Tests; Molecular Structure; Pain; Pseudomonas aeruginosa; Quantitative Structure-Activity Relationship; Rats; Salmonella typhi; Spleen; Staphylococcus aureus; Streptococcus pyogenes; Ulcer | 2020 |
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
Curcumin inhibits the growth of AGS human gastric carcinoma cells in vitro and shows synergism with 5-fluorouracil.
Topics: Cell Division; Curcumin; Dose-Response Relationship, Drug; Drug Synergism; Fluorouracil; G2 Phase; Humans; Mitosis; Stomach Neoplasms; Tumor Cells, Cultured | 2004 |
[The inhibitory effect of curcumin on the growth of human colon cancer cells (HT-29, WiDr) in vitro].
Topics: Antineoplastic Agents; Cell Division; Cell Line, Tumor; Colonic Neoplasms; Curcumin; Flow Cytometry; Fluorouracil; HT29 Cells; Humans | 2005 |
Synergistic inhibitory effects of curcumin and 5-fluorouracil on the growth of the human colon cancer cell line HT-29.
Topics: Cell Proliferation; Colonic Neoplasms; Curcumin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Synergism; Fluorouracil; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans | 2006 |
Curcumin enhances the effects of 5-fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF-1R.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Colorectal Neoplasms; Curcumin; Cyclooxygenase 2; Dose-Response Relationship, Drug; Drug Synergism; ErbB Receptors; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Insulin-Like Growth Factor Binding Protein 3; Organoplatinum Compounds; Oxaliplatin; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1 | 2008 |
[Curcumin promotes apoptosis of esophageal squamous carcinoma cell lines through inhibition of NF-kappaB signaling pathway].
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Curcumin; Esophageal Neoplasms; Fluorouracil; Humans; NF-kappa B; Proto-Oncogene Proteins c-bcl-2; Signal Transduction | 2008 |
Implication of functional activity for determining therapeutic efficacy of suicide genes in vitro.
Topics: Animals; Apoptosis; Cell Line; Cell Survival; Chromatography, High Pressure Liquid; Curcumin; Cytosine Deaminase; DNA Fragmentation; Drug Synergism; Electroporation; Enzyme-Linked Immunosorbent Assay; Flucytosine; Fluorouracil; Gene Expression Regulation; Genes, Transgenic, Suicide; Genetic Vectors; HT29 Cells; Humans; Pentosyltransferases; Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Transfection | 2008 |
Is there a role for herbal medicine in the treatment of pancreatic cancer?. Highlights from the "44th ASCO Annual Meeting". Chicago, IL, USA. May 30 - June 3, 2008.
Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Curcumin; Deoxycytidine; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Fluorouracil; Gemcitabine; Herbal Medicine; Humans; Multicenter Studies as Topic; Pancreatic Neoplasms; Plant Preparations | 2008 |
Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model.
Topics: Animals; Antineoplastic Agents; Apoptosis; Capecitabine; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Curcumin; Cyclin D1; Cyclooxygenase 2; Deoxycytidine; Drug Synergism; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Male; Matrix Metalloproteinase 9; Mice; Neoplasm Metastasis; NF-kappa B; Receptors, CXCR4; Vascular Endothelial Growth Factor A | 2009 |
Curcumin targets FOLFOX-surviving colon cancer cells via inhibition of EGFRs and IGF-1R.
Topics: Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Curcumin; ErbB Receptors; Fluorouracil; Humans; Organoplatinum Compounds; Oxaliplatin; Receptor, IGF Type 1; RNA, Small Interfering | 2010 |
Modulatory effects of curcumin on multi-drug resistance-associated protein 5 in pancreatic cancer cells.
Topics: Anticarcinogenic Agents; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Survival; Curcumin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluoresceins; Fluorescent Antibody Technique; Fluorescent Dyes; Fluorouracil; Genistein; Humans; Immunohistochemistry; Multidrug Resistance-Associated Proteins; Pancreatic Neoplasms | 2011 |
Comparison of the effect of p65 siRNA and curcumin in promoting apoptosis in esophageal squamous cell carcinoma cells and in nude mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Shape; Curcumin; Cytoplasm; Esophageal Neoplasms; Fluorouracil; Gene Knockdown Techniques; Humans; Male; Mice; Mice, Nude; NF-kappa B; RNA Interference; RNA, Small Interfering; Signal Transduction; Transcription Factor RelA; Tumor Burden; Xenograft Model Antitumor Assays | 2012 |
[Reversing effects of curcumin on multi-drug resistance of Bel7402/5-fu cell line].
Topics: Cell Line, Tumor; Curcumin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluorouracil; Humans | 2012 |
Hexahydrocurcumin enhances inhibitory effect of 5-fluorouracil on HT-29 human colon cancer cells.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Proliferation; Cell Survival; Curcumin; Cyclooxygenase 2; Down-Regulation; Drug Synergism; Fluorouracil; HT29 Cells; Humans; RNA, Messenger | 2012 |
Curcumin potentiates the antitumor effects of 5-FU in treatment of esophageal squamous carcinoma cells through downregulating the activation of NF-κB signaling pathway in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Squamous Cell; Cell Line, Tumor; Curcumin; Cyclin D1; Down-Regulation; Drug Synergism; Esophageal Neoplasms; Fluorouracil; Humans; I-kappa B Proteins; Immunohistochemistry; Male; Mice; Mice, Inbred BALB C; Mice, Nude; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Tumor Burden; Xenograft Model Antitumor Assays | 2012 |
Effects of hexahydrocurcumin in combination with 5-fluorouracil on dimethylhydrazine-induced colon cancer in rats.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Colonic Neoplasms; Curcumin; Cyclooxygenase 1; Cyclooxygenase 2; Dimethylhydrazines; Fluorouracil; Gene Expression Regulation, Enzymologic; Immunohistochemistry; Male; Membrane Proteins; Rats; Rats, Wistar | 2012 |
Mechanistic evaluation of the signaling events regulating curcumin-mediated chemosensitization of breast cancer cells to 5-fluorouracil.
Topics: Annexin A5; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Caspases; Cell Line, Tumor; Curcumin; DNA Fragmentation; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Female; Fluorouracil; Humans; MCF-7 Cells; Mitogen-Activated Protein Kinases; NF-kappa B; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; Signal Transduction; Thymidylate Synthase; Up-Regulation | 2013 |
Curcumin enhances the effect of chemotherapy against colorectal cancer cells by inhibition of NF-κB and Src protein kinase signaling pathways.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Line, Tumor; Colorectal Neoplasms; Curcumin; Drug Synergism; Fluorouracil; Humans; Microscopy, Electron, Transmission; NF-kappa B; Signal Transduction; src-Family Kinases | 2013 |
The drug resistance suppression induced by curcuminoids in colon cancer SW-480 cells is mediated by reactive oxygen species-induced disruption of the microRNA-27a-ZBTB10-Sp axis.
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Curcumin; Down-Regulation; Drug Resistance, Neoplasm; Fluorouracil; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; MicroRNAs; Plasmids; Reactive Oxygen Species; Repressor Proteins; RNA Interference; RNA, Small Interfering; Signal Transduction; Sp Transcription Factors; Transfection | 2013 |
Synergetic effect of SLN-curcumin and LDH-5-Fu on SMMC-7721 liver cancer cell line.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Curcumin; Drug Delivery Systems; Drug Synergism; Fluorouracil; Humans; Hydroxides; Lipids; Liver Neoplasms; Nanoparticles | 2013 |
[Curcumin combined FOLFOX induced cell apoptosis of gastric cancer and its mechanism research].
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; Cell Proliferation; Curcumin; Fluorouracil; Humans; Leucovorin; Organoplatinum Compounds; Proto-Oncogene Proteins c-bcl-2; Stomach Neoplasms | 2013 |
Protective effect of curcumin on chemotherapy-induced intestinal dysfunction.
Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Behavior, Animal; Biomarkers; Caspase 3; Curcumin; Cytoprotection; D-Amino-Acid Oxidase; Endotoxins; Fluorouracil; Ileum; Intestinal Mucosa; Lactic Acid; Protective Agents; Rats; Rats, Wistar; Time Factors; Weight Loss | 2013 |
Curcumin chemosensitizes 5-fluorouracil resistant MMR-deficient human colon cancer cells in high density cultures.
Topics: Antineoplastic Agents; Apoptosis; Cell Count; Cell Line, Tumor; Colonic Neoplasms; Curcumin; DNA Mismatch Repair; Drug Resistance, Neoplasm; Fluorouracil; HCT116 Cells; Humans; Neoplastic Stem Cells; Spheroids, Cellular; Tumor Cells, Cultured | 2014 |
Curcumin reduces cytotoxicity of 5-Fluorouracil treatment in human breast cancer cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Curcumin; Female; Fluorouracil; Humans | 2015 |
Curcumin and 5-fluorouracil-loaded, folate- and transferrin-decorated polymeric magnetic nanoformulation: a synergistic cancer therapeutic approach, accelerated by magnetic hyperthermia.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line; Combined Modality Therapy; Curcumin; Drug Carriers; Fluorouracil; Folic Acid; Humans; Hyperthermia, Induced; Lactic Acid; Magnetite Nanoparticles; MCF-7 Cells; Mice; Nanoconjugates; Nanomedicine; Nanotechnology; Neoplasms; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Transferrin | 2014 |
In vitro combinatorial anticancer effects of 5-fluorouracil and curcumin loaded N,O-carboxymethyl chitosan nanoparticles toward colon cancer and in vivo pharmacokinetic studies.
Topics: Animals; Antineoplastic Agents; Area Under Curve; Blood Coagulation; Cell Cycle; Cell Line; Cell Line, Tumor; Chitosan; Colonic Neoplasms; Curcumin; Drug Carriers; Drug Delivery Systems; Female; Fluorouracil; Hemolysis; HT29 Cells; Humans; Hydrogen-Ion Concentration; Membrane Potentials; Mice; Nanoparticles; Spectroscopy, Fourier Transform Infrared | 2014 |
Combinatorial anticancer effects of curcumin and 5-fluorouracil loaded thiolated chitosan nanoparticles towards colon cancer treatment.
Topics: Animals; Biological Availability; Cell Cycle; Cell Line, Tumor; Chitosan; Colonic Neoplasms; Curcumin; Delayed-Action Preparations; Fluorouracil; Humans; Membrane Potential, Mitochondrial; Mice; Nanoparticles | 2014 |
Curcumin suppresses crosstalk between colon cancer stem cells and stromal fibroblasts in the tumor microenvironment: potential role of EMT.
Topics: Coculture Techniques; Colonic Neoplasms; Curcumin; Epithelial-Mesenchymal Transition; Fibroblasts; Fluorouracil; HCT116 Cells; Humans; Signal Transduction; Stromal Cells; Transforming Growth Factor beta; Tumor Microenvironment | 2014 |
Inkjet printing of transdermal microneedles for the delivery of anticancer agents.
Topics: Administration, Cutaneous; Animals; Antineoplastic Agents; Cisplatin; Computer Systems; Curcumin; Drug Delivery Systems; Drug Liberation; Fluorouracil; High-Energy Shock Waves; Humans; Needles; Polyethylene Glycols; Polyvinyls; Swine; Technology, Pharmaceutical | 2015 |
Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelial-to-mesenchymal transition in chemoresistant colorectal cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Colorectal Neoplasms; Curcumin; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Male; Mice, Nude; MicroRNAs; Xenograft Model Antitumor Assays | 2015 |
Nanopotentiated combination cancer therapy: Chemotherapeutic and chemosensitizer (2C approach).
Topics: Antineoplastic Agents, Phytogenic; Curcumin; Drug Delivery Systems; Drug Therapy, Combination; Flavonoids; Fluorouracil; Humans; Models, Biological; Nanoparticles; Neoplasms; Resveratrol; Stilbenes | 2015 |
Curcumin potentiates antitumor activity of 5-fluorouracil in a 3D alginate tumor microenvironment of colorectal cancer.
Topics: Alginates; Animals; Apoptosis; Cell Proliferation; Colorectal Neoplasms; Curcumin; Drug Synergism; Fluorouracil; Glucuronic Acid; HCT116 Cells; Hexuronic Acids; Humans; Matrix Metalloproteinase 9; Mice; Neoplasm Invasiveness; Receptors, CXCR4; Signal Transduction; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2015 |
Synergistic effect of cucurbitacin B in combination with curcumin via enhancing apoptosis induction and reversing multidrug resistance in human hepatoma cells.
Topics: Adenosine Triphosphate; Animals; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Body Weight; Carcinoma, Hepatocellular; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Curcumin; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Activation; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Intracellular Space; Liver Neoplasms; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Triterpenes; Xenograft Model Antitumor Assays | 2015 |
Berberine and Curcumin Target Survivin and STAT3 in Gastric Cancer Cells and Synergize Actions of Standard Chemotherapeutic 5-Fluorouracil.
Topics: Berberine; Cell Line, Tumor; Cell Survival; Curcumin; DNA; Drug Resistance, Neoplasm; Drug Synergism; Fluorouracil; Humans; Inhibitor of Apoptosis Proteins; NF-kappa B; Quercetin; Signal Transduction; STAT3 Transcription Factor; Stomach Neoplasms; Survivin | 2015 |
Combinatorial Effects of Curcumin with an Anti-Neoplastic Agent on Head and Neck Squamous Cell Carcinoma Through the Regulation of EGFR-ERK1/2 and Apoptotic Signaling Pathways.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cisplatin; Curcumin; Doxorubicin; ErbB Receptors; Fluorouracil; Head and Neck Neoplasms; Humans; MAP Kinase Signaling System; Signal Transduction; Squamous Cell Carcinoma of Head and Neck | 2016 |
Comparative evaluation of PLGA nanoparticle delivery system for 5-fluorouracil and curcumin on squamous cell carcinoma.
Topics: Apoptosis; Carcinoma, Squamous Cell; Caspase 3; Cell Line, Tumor; Cell Proliferation; Curcumin; Drug Delivery Systems; Drug Screening Assays, Antitumor; Fluorouracil; Head and Neck Neoplasms; Humans; Lactic Acid; Laryngeal Neoplasms; Nanoparticles; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Squamous Cell Carcinoma of Head and Neck | 2016 |
Curcumin Enhances the Effects of 5-Fluorouracil and Oxaliplatin in Inducing Gastric Cancer Cell Apoptosis Both In Vitro and In Vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Curcumin; Drug Synergism; Fluorouracil; Humans; Male; Mice, Inbred BALB C; Mice, Nude; Organoplatinum Compounds; Oxaliplatin; Stomach Neoplasms; Xenograft Model Antitumor Assays | 2016 |
Integration of in silico modeling, prediction by binding energy and experimental approach to study the amorphous chitin nanocarriers for cancer drug delivery.
Topics: Adenocarcinoma; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Chitin; Curcumin; Docetaxel; Drug Carriers; Fluorouracil; Humans; Molecular Docking Simulation; Nanoparticles; Stomach; Stomach Neoplasms; Taxoids; Thermodynamics | 2016 |
Curcumin Inhibits 5-Fluorouracil-induced Up-regulation of CXCL1 and CXCL2 of the Colon Associated with Attenuation of Diarrhoea Development.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Antioxidants; Chemokine CXCL1; Chemokine CXCL2; Colon, Descending; Curcumin; Diarrhea; Dietary Supplements; E1A-Associated p300 Protein; Enzyme Inhibitors; Fluorouracil; Gene Expression Regulation; Intestinal Mucosa; Male; Mice, Inbred C57BL; NF-kappa B; Severity of Illness Index; Tissue Culture Techniques | 2016 |
In vitro additive antitumor effects of dimethoxycurcumin and 5-fluorouracil in colon cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Cell Cycle; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Curcumin; Dose-Response Relationship, Drug; Drug Synergism; Endoplasmic Reticulum; Fluorouracil; Humans; Membrane Potential, Mitochondrial; Mice; Reactive Oxygen Species; Signal Transduction | 2017 |
Nanoparticle assisted solvent selective transdermal combination therapy of curcumin and 5-flurouracil for efficient cancer treatment.
Topics: Administration, Cutaneous; Animals; Antineoplastic Agents; Cell Line, Tumor; Curcumin; Delayed-Action Preparations; Drug Delivery Systems; Fluorouracil; Humans; Nanoparticles; Rats; Rats, Wistar; Skin; Skin Absorption; Solvents | 2017 |
Nuclear IGF-1R predicts chemotherapy and targeted therapy resistance in metastatic colorectal cancer.
Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Cell Nucleus; Cell Survival; Cetuximab; Colorectal Neoplasms; Curcumin; Dasatinib; Drug Resistance, Neoplasm; Fatty Acids, Unsaturated; Female; Fluorouracil; Gene Silencing; HCT116 Cells; HT29 Cells; Humans; Leucovorin; Male; Middle Aged; Molecular Chaperones; Molecular Targeted Therapy; Niacinamide; Organoplatinum Compounds; Oxaliplatin; Panitumumab; Phenylurea Compounds; Protein Inhibitors of Activated STAT; Protein Transport; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins p21(ras); Pyrimidines; Pyrroles; Receptor, IGF Type 1; Signal Transduction; Sorafenib | 2017 |
Curcumin synergizes with 5-fluorouracil by impairing AMPK/ULK1-dependent autophagy, AKT activity and enhancing apoptosis in colon cancer cells with tumor growth inhibition in xenograft mice.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Autophagy-Related Protein-1 Homolog; Cell Line, Tumor; Colonic Neoplasms; Curcumin; Drug Resistance, Neoplasm; Drug Synergism; Fluorouracil; Humans; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred BALB C; Protein Kinases; Xenograft Model Antitumor Assays | 2017 |
Concentration- Dependent Effects of Curcumin on 5-Fluorouracil Efficacy in Bladder Cancer Cells
Topics: Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apoptosis; Cell Proliferation; Curcumin; Dose-Response Relationship, Drug; Fluorouracil; Humans; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 2017 |
Turmeric extract, with absorbable curcumin, has potent anti-metastatic effect in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Colorectal Neoplasms; Curcuma; Curcumin; Fluorouracil; Humans; Male; Mice; Mice, Inbred BALB C; Plant Extracts; Signal Transduction; Tumor Burden; Xenograft Model Antitumor Assays | 2018 |
Nrf2 is a key factor in the reversal effect of curcumin on multidrug resistance in the HCT‑8/5‑Fu human colorectal cancer cell line.
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Curcumin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluorouracil; Genes, bcl-2; Humans; NF-E2-Related Factor 2; Signal Transduction | 2018 |
Dual-Targeting Nanoparticles: Codelivery of Curcumin and 5-Fluorouracil for Synergistic Treatment of Hepatocarcinoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Biotin; Carcinoma, Hepatocellular; Curcumin; Disaccharides; Drug Carriers; Drug Liberation; Drug Synergism; Fluorouracil; Hep G2 Cells; Humans; Liver Neoplasms; Mice; Nanoparticles; Polyethylene Glycols; Polyglactin 910; Tissue Distribution; Xenograft Model Antitumor Assays | 2019 |
A Biodegradable Stent with Surface Functionalization of Combined-Therapy Drugs for Colorectal Cancer.
Topics: Absorbable Implants; Animals; Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Colorectal Neoplasms; Curcumin; Drug Liberation; Drug Therapy, Combination; Drug-Eluting Stents; Fibroins; Fluorouracil; Humans; Mice; Mice, Nude; Nanofibers; Polydioxanone; Surface Properties; Transplantation, Heterologous | 2018 |
Tetrahydrocurcumin, Curcumin, and 5-Fluorouracil Effects on Human Esophageal Carcinoma Cells.
Topics: Antineoplastic Agents; Cell Proliferation; Curcumin; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Fluorouracil; Humans; Molecular Structure; Structure-Activity Relationship; Tumor Cells, Cultured | 2019 |
Magnetic bio-metal-organic framework nanocomposites decorated with folic acid conjugated chitosan as a promising biocompatible targeted theranostic system for cancer treatment.
Topics: Animals; Biocompatible Materials; Cell Death; Cell Line, Tumor; Cell Survival; Chitosan; Curcumin; Drug Liberation; Erythrocytes; Ferric Compounds; Fluorouracil; Folic Acid; Hemolysis; Humans; Magnetic Resonance Imaging; Magnetics; Metal-Organic Frameworks; Mice; Mice, Inbred BALB C; Nanocomposites; Neoplasms; NIH 3T3 Cells; Phantoms, Imaging; Protein Corona; Theranostic Nanomedicine; X-Ray Diffraction | 2019 |
The Influence of Curcumin on the Downregulation of MYC, Insulin and IGF-1 Receptors: A possible Mechanism Underlying the Anti-Growth and Anti-Migration in Chemoresistant Colorectal Cancer Cells.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Curcuma; Curcumin; Down-Regulation; Drug Resistance, Neoplasm; Fluorouracil; Gene Expression Regulation, Neoplastic; Genes, myc; Humans; Insulin; Plant Extracts; Receptor, IGF Type 1; Receptors, Somatomedin | 2019 |
FOLFIRI-Mediated Toxicity in Human Aortic Smooth Muscle Cells and Possible Amelioration with Curcumin and Quercetin.
Topics: Antineoplastic Combined Chemotherapy Protocols; Aorta; Apoptosis; Apoptosis Regulatory Proteins; Camptothecin; Cells, Cultured; Curcumin; DNA Damage; Fluorouracil; Humans; Leucovorin; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Necrosis; Oxidative Stress; Quercetin; Signal Transduction | 2020 |
Curcumin inhibits NF-kB and Wnt/β-catenin pathways in cervical cancer cells.
Topics: Antineoplastic Agents; Apoptosis; beta Catenin; Cell Proliferation; Curcumin; Down-Regulation; Enzyme Inhibitors; Female; Fluorouracil; HeLa Cells; Humans; NF-kappa B; Signal Transduction; Uterine Cervical Neoplasms; Wnt Proteins; Wnt Signaling Pathway | 2019 |
Can curcumin along with chemotherapeutic drug and lipid provide an effective treatment of metastatic colon cancer and alter multidrug resistance?
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Colonic Neoplasms; Curcumin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flavonoids; Fluorouracil; Humans; Lipids; Lymphatic System; Neoplasm Metastasis; Neoplasm Recurrence, Local | 2019 |
Gercumin synergizes the action of 5-fluorouracil and oxaliplatin against chemoresistant human cancer colon cells.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Curcumin; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Fluorouracil; HCT116 Cells; HT29 Cells; Humans; Organoplatinum Compounds; Oxaliplatin | 2020 |
Redox responsive xylan-SS-curcumin prodrug nanoparticles for dual drug delivery in cancer therapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Curcumin; Disulfides; Drug Delivery Systems; Drug Liberation; Drug Stability; Fluorouracil; Hemolysis; HT29 Cells; Humans; Nanoparticles; Neoplasms; Oxidation-Reduction; Particle Size; Prodrugs; Spectroscopy, Fourier Transform Infrared; Stearic Acids; Xylans | 2020 |
(Curcumin+sildenafil) enhances the efficacy of 5FU and anti-PD1 therapies in vivo.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Colorectal Neoplasms; Curcumin; Drug Synergism; Fluorouracil; Histone Deacetylases; Humans; Mice; Mice, Inbred BALB C; Programmed Cell Death 1 Receptor; Sildenafil Citrate; Vasodilator Agents; Xenograft Model Antitumor Assays | 2020 |
Hydrazinocurcumin and 5-fluorouracil enhance apoptosis and restrain tumorigenicity of HepG2 cells via disrupting the PTEN-mediated PI3K/Akt signaling pathway.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Curcumin; Drug Synergism; Fluorouracil; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Hydrazines; Liver Neoplasms; Mice, Inbred BALB C; Mice, Nude; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Signal Transduction; Tumor Burden; Xenograft Model Antitumor Assays | 2020 |
Curcumin may reverse 5-fluorouracil resistance on colonic cancer cells by regulating TET1-NKD-Wnt signal pathway to inhibit the EMT progress.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Calcium-Binding Proteins; Cell Movement; Cell Proliferation; Cell Survival; Colonic Neoplasms; Curcumin; Drug Resistance, Neoplasm; Fluorouracil; HCT116 Cells; Humans; Mixed Function Oxygenases; PAX6 Transcription Factor; Proto-Oncogene Proteins; Transfection; Wnt Signaling Pathway | 2020 |
Antitumor effects of curcumin on the proliferation, migration and apoptosis of human colorectal carcinoma HCT‑116 cells.
Topics: Animals; Apoptosis; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Curcumin; Fluorouracil; HCT116 Cells; Humans; Mice; NF-kappa B; Signal Transduction; Xenograft Model Antitumor Assays | 2020 |
[Curcumin mediates IL-6/STAT3 signaling pathway to repair intestinal mucosal injury induced by 5-FU chemotherapy for colon cancer].
Topics: Animals; Colonic Neoplasms; Curcumin; Fluorouracil; Interleukin-6; Intestinal Mucosa; Rats; Rats, Sprague-Dawley; Signal Transduction; STAT3 Transcription Factor | 2021 |
Low curcumin concentration enhances the anticancer effect of 5-fluorouracil against colorectal cancer.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Curcumin; Down-Regulation; Drug Synergism; Female; Fluorouracil; Humans; Leukocyte L1 Antigen Complex; Mice; Mice, Nude; Signal Transduction; Xenograft Model Antitumor Assays | 2021 |
The protective effects of hesperidin and curcumin on 5-fluorouracil-induced nephrotoxicity in mice.
Topics: Animals; Antioxidants; Curcumin; Fluorouracil; Glutathione; Hesperidin; Humans; Kidney; Malondialdehyde; Mice; Oxidative Stress; Renal Insufficiency; Superoxide Dismutase | 2021 |
New Hybrids Based on Curcumin and Resveratrol: Synthesis, Cytotoxicity and Antiproliferative Activity against Colorectal Cancer Cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; CHO Cells; Colorectal Neoplasms; Cricetinae; Cricetulus; Curcumin; Drug Design; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Resveratrol; Rhodamines | 2021 |
RNA-seq and
Topics: Animals; Cell Line; Curcumin; Disease Models, Animal; Epithelial Cells; Fluorouracil; Gene Expression Regulation; Humans; Interleukin-6; Intestinal Mucosa; Mucositis; Neoplasms; Rats; RNA-Seq; Signal Transduction; STAT3 Transcription Factor | 2021 |
Gut microbiota enhances the chemosensitivity of hepatocellular carcinoma to 5-fluorouracil in vivo by increasing curcumin bioavailability.
Topics: Apoptosis; Biological Availability; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Curcumin; Fluorouracil; Gastrointestinal Microbiome; Humans; Liver Neoplasms; Phosphatidylinositol 3-Kinases | 2021 |
Anti-cancer activity of amorphous curcumin preparation in patient-derived colorectal cancer organoids.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinogenesis; Cell Cycle; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Curcumin; Drug Synergism; Fluorouracil; Humans; Irinotecan; Male; Mice, SCID; Neoplastic Stem Cells; Organoids; Oxaliplatin | 2021 |
Curcumin Reverses NNMT-Induced 5-Fluorouracil Resistance via Increasing ROS and Cell Cycle Arrest in Colorectal Cancer Cells.
Topics: Animals; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Curcumin; Down-Regulation; Drug Synergism; Fluorouracil; Humans; Inhibitory Concentration 50; Male; Mice, Inbred BALB C; Mice, Nude; Nicotinamide N-Methyltransferase; Phosphorylation; Reactive Oxygen Species; STAT3 Transcription Factor; Xenograft Model Antitumor Assays | 2021 |
[Curcumin combined with 5-FU promotes autophagy and down-regulates the expression of Yes-associated protein (YAP) in hepatocellular carcinoma cells].
Topics: Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Curcumin; Fluorouracil; Humans; Liver Neoplasms | 2021 |
Evaluation of the Effects of Nanomicellar Curcumin, Berberine, and Their Combination with 5-Fluorouracil on Breast Cancer Cells.
Topics: Apoptosis; Berberine; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Curcumin; Drug Synergism; Female; Fluorouracil; Humans | 2021 |
5-fluorouracil and curcumin with pectin coating as a treatment regimen for titanium dioxide with dimethylhydrazine-induced colon cancer model.
Topics: Animals; Apoptosis; Cell Line, Tumor; Colonic Neoplasms; Curcumin; Dimethylhydrazines; Fluorouracil; Pectins; Rats; Rats, Wistar; Spectroscopy, Fourier Transform Infrared; Titanium | 2022 |
Curcumin inhibits the cancer‑associated fibroblast‑derived chemoresistance of gastric cancer through the suppression of the JAK/STAT3 signaling pathway.
Topics: Biological Products; Cancer-Associated Fibroblasts; Chemokines; Curcumin; Drug Resistance, Neoplasm; Fluorouracil; Humans; Interleukin-6; Janus Kinases; Ligands; Signal Transduction; STAT3 Transcription Factor; Stomach Neoplasms | 2022 |
Natural Compounds or Their Derivatives against Breast Cancer: A Computational Study.
Topics: Apigenin; BRCA1 Protein; BRCA2 Protein; Breast Neoplasms; Citrinin; Curcumin; Female; Fluorouracil; Genes, BRCA1; Genetic Predisposition to Disease; Germ-Line Mutation; Humans; Molecular Docking Simulation | 2022 |
ROS-generating, pH-responsive and highly tunable reduced graphene oxide-embedded microbeads showing intrinsic anticancer properties and multi-drug co-delivery capacity for combination cancer therapy.
Topics: Alginates; Chitosan; Curcumin; Drug Carriers; Drug Liberation; Fluorouracil; Graphite; Humans; Hydrogen-Ion Concentration; Microspheres; Neoplasms; Reactive Oxygen Species | 2022 |
Comparative study between two different morphological structures based on polylactic acid, nanocellulose and magnetite for co-delivery of flurouracil and curcumin.
Topics: Antineoplastic Agents; Curcumin; Drug Carriers; Ferrosoferric Oxide; Fluorouracil; Micelles; Particle Size; Polyesters; Polymers | 2023 |
Rapid generation of homogenous tumor spheroid microtissues in a scaffold-free platform for high-throughput screening of a novel combination nanomedicine.
Topics: Animals; Cell Line, Tumor; Curcumin; Drug Carriers; Drug Delivery Systems; Fluorouracil; High-Throughput Screening Assays; Humans; Nanomedicine; Nanoparticles; Neoplasms | 2023 |
Development of the new pH-driven carrier from alginate/carboxymethyl starch bio-coated co-drugs@COF-OH for controlled and concomitant colon cancer treatment.
Topics: Alginates; Colonic Neoplasms; Curcumin; Drug Carriers; Excipients; Fluorouracil; Humans; Hydrogen-Ion Concentration; Metal-Organic Frameworks; Pharmaceutical Preparations | 2023 |
Drug Delivery on Mg-MOF-74: The Effect of Drug Solubility on Pharmacokinetics.
Topics: Curcumin; Fluorouracil; Ibuprofen; Pharmaceutical Preparations; Solubility | 2023 |
Dual Drug-Loaded Nanoliposomes Encapsulating Curcumin and 5-Fluorouracil with Advanced Medicinal Applications: Self-Monitoring and Antitumor Therapy.
Topics: Animals; Antineoplastic Agents; Curcumin; Fluorouracil; Liposomes; Nanoparticles; Particle Size; Zebrafish | 2023 |
Folic Acid-Functionalized Albumin/Graphene Oxide Nanocomposite to Simultaneously Deliver Curcumin and 5-Fluorouracil into Human Colorectal Cancer Cells: An
Topics: Albumins; Colonic Neoplasms; Curcumin; Excipients; Fluorouracil; Folic Acid; Graphite; Humans | 2023 |
Turmeric (Curcuma longa) inhibits inflammatory nuclear factor (NF)-κB and NF-κB-regulated gene products and induces death receptors leading to suppressed proliferation, induced chemosensitization, and suppressed osteoclastogenesis.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Capecitabine; Cell Differentiation; Cell Proliferation; Curcuma; Cyclin D1; Deoxycytidine; Down-Regulation; Fluorouracil; HCT116 Cells; HT29 Cells; Humans; Mice; NF-kappa B; Osteoclasts; Paclitaxel; Plant Extracts; RANK Ligand; Reactive Oxygen Species; Receptors, CXCR4; Receptors, Death Domain; STAT3 Transcription Factor; X-Linked Inhibitor of Apoptosis Protein | 2012 |
Diterpenoid C of Radix Curcumae: an inhibitor of proliferation and inducer of apoptosis in human colon adenocarcinoma cells acting via inhibiting MAPK signaling pathway.
Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Curcuma; Diterpenes; Fluorouracil; Humans; Inhibitory Concentration 50; MAP Kinase Signaling System; Organoplatinum Compounds; Oxaliplatin; Time Factors | 2014 |
[Reversal Effect of curcuma wenyujin extract on SGC-7901/VCR induced subcutaneous transplanted tumor in nude mice and its effect on the expression of P-glycoprotein].
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cisplatin; Curcuma; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drugs, Chinese Herbal; Fluorouracil; Guanylate Cyclase; Mice; Mice, Nude; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Stomach Neoplasms; Vincristine | 2014 |
The chemopreventive potential of Curcuma purpurascens rhizome in reducing azoxymethane-induced aberrant crypt foci in rats.
Topics: Aberrant Crypt Foci; Animals; Antioxidants; Apoptosis; Azoxymethane; Chemoprevention; Colonic Neoplasms; Curcuma; Dose-Response Relationship, Drug; Fluorouracil; Male; Oxidative Stress; Plant Extracts; Rats; Rats, Sprague-Dawley; Rhizome | 2015 |
Chemopreventive effects of FITOPROT against 5-fluorouracil-induced toxicity in HaCaT cells.
Topics: Anticarcinogenic Agents; Antioxidants; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; Curcuma; Cytokines; Flavonoids; Fluorouracil; Humans; Interleukin-1beta; Interleukin-6; Keratinocytes; Ligases; NF-kappa B; Protective Agents; Stomatitis; Tumor Necrosis Factor-alpha | 2018 |
Mucoadhesive formulation containing Curcuma longa L. reduces oral mucositis induced by 5-fluorouracil in hamsters.
Topics: Animals; Cricetinae; Curcuma; Drug Compounding; Fluorouracil; Male; Mesocricetus; Plant Extracts; Stomatitis; Wound Healing | 2019 |