fluorouracil has been researched along with chloroquine in 41 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 7 (17.07) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 11 (26.83) | 29.6817 |
2010's | 16 (39.02) | 24.3611 |
2020's | 7 (17.07) | 2.80 |
Authors | Studies |
---|---|
Topliss, JG; Yoshida, F | 1 |
Clark, AM; Dunbar, DC; Muhammad, I; Takamatsu, S; Walker, LA | 1 |
Busson, R; Chepkwony, H; De Witte, P; Govaerts, C; Hoogmartens, J; Hoornaert, G; Janssens, L; Kuria, KA; Laekeman, G; Maes, L; Quirynen, L; Roets, E; Zupko, I | 1 |
Lombardo, F; Obach, RS; Waters, NJ | 1 |
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J | 1 |
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Dagher, RK; Shoemaker, JP | 1 |
Shoemaker, JP | 2 |
Muench, KH | 1 |
Hussain Qadri, SM; Williams, RP | 1 |
Ota, K | 1 |
Johnston, GS; Jones, AE | 1 |
Diehl, H; Engelke, M; Huhtala, A; Mäenpää, H; Mannerström, M; Mäntylä, E; Mäntylä, M; Marselos, M; Pappas, P; Salminen, L; Tähti, H; Toimela, T; Uusitalo, H; Zorn-Kruppa, M | 1 |
Feng, FY; Kanade, VD; Nayak, R; Nyati, MK | 1 |
Hiyoshi, M; Hongo, K; Kaneko, M; Kawai, K; Kitayama, J; Nagawa, H; Nishikawa, T; Okaji, Y; Sasaki, K; Shuno, Y; Sunami, E; Takahashi, K; Tsuno, NH; Tsurita, G | 1 |
Hiyoshi, M; Hongo, K; Kaneko, M; Kawai, K; Kitayama, J; Murono, K; Nirei, T; Sasaki, K; Sunami, E; Tada, N; Takahashi, K; Tsuno, NH | 1 |
Greenfield, NP; Maibach, H | 1 |
Choi, JH; Lee, YY; Park, BB; Won, YW; Yoon, JS | 1 |
Cheng, PC; Chiang, WF; Hong, WZ; Lee, SY; Lin, MH; Lin, PY; Liu, SY; Liu, YC; Yen, CY | 1 |
Bläuer, M; Hashimoto, D; Hirota, M; Ikonen, NH; Laukkarinen, J; Sand, J | 1 |
Cai, X; Liang, X; Liu, J; Liu, X; Ma, R; Tang, J | 1 |
Benincasa, M; Magnani, G; Mancini, S; Mariani, F; Palumbo, C; Pedroni, M; Roncucci, L; Sena, P | 1 |
Akpinar, B; Debnath, S; Laukova, J; Olsson, M; Safarikova, B; Vaculova, AH; Zhivotovsky, B | 1 |
-Y-Xie, D; Chen, H; Li, LQ; Pan, D; Zhang, SW; Zheng, XL | 1 |
Bu, Y; Huang, H; Tang, J; Zhang, L; Zhang, X | 1 |
Basu, S; Ghosh, C; Nandi, A | 1 |
Dos Santos, DC; Falasco, BF; Gorgulho, CM; Junior, JPA; Kaneno, R; Lotze, MT; Romagnoli, GG; Sanzochi Fogolin, C; Ureshino, RP; Zamame Ramirez, JA | 1 |
Ahmad, SI | 1 |
Chen, C; Chen, J; Fan, G; Liu, X; Lu, H; Na, R; Peng, Z; Song, G; Tang, H; Wang, X; Wang, Y; Xiao, C; Yan, D; Zhuang, G | 1 |
Islam, MK; Lian, HK; Lim, JCW; Sagineedu, SR; Selvarajoo, N; Stanslas, J | 1 |
Adrees, AO; Akbar, N; Al-Shahrabi, R; Khan, NA; Manzoor, S; Muhammad, JS; Qalaji, MR; Roberta, C; Saeed, BQ; Siddiqui, R | 1 |
Duarte, D; Nunes, M; Ricardo, S; Vale, N | 1 |
Ju, S; Jung, Y; Kang, C; Kim, J | 1 |
3 review(s) available for fluorouracil and chloroquine
Article | Year |
---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Multiple combination therapy in cancer chemotherapy in Japan.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Chloroquine; Cyclophosphamide; Cytarabine; Drug Synergism; Fluorouracil; Humans; Japan; Leukemia; Lymphoma; Mercaptopurine; Mitomycins; Neoplasms; Podophyllin; Prednisolone; Thiotepa; Vincristine; Vitamin K 1 | 1969 |
Pharmacological Modulation of Apoptosis and Autophagy in Pancreatic Cancer Treatment.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Chloroquine; ErbB Receptors; Fluorouracil; Humans; Metformin; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Resveratrol; Sirolimus; TOR Serine-Threonine Kinases | 2022 |
38 other study(ies) available for fluorouracil and chloroquine
Article | Year |
---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Antimalarial, cytotoxic, and antifungal alkaloids from Duguetia hadrantha.
Topics: Alkaloids; Animals; Antifungal Agents; Antimalarials; Antineoplastic Agents, Phytogenic; Brazil; Cell Adhesion; Cell Aggregation; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Paraguay; Plant Extracts; Plants, Medicinal; Plasmodium falciparum; Spectrophotometry, Ultraviolet; Tumor Cells, Cultured | 2001 |
The antiplasmodial activity of isolates from Ajuga remota.
Topics: Animals; Antimalarials; Antineoplastic Agents; Chloroquine; Chromatography, Thin Layer; Diterpenes; Drug Resistance, Microbial; Drug Screening Assays, Antitumor; Ergosterol; Fluorouracil; Humans; In Vitro Techniques; Inhibitory Concentration 50; Kenya; L-Lactate Dehydrogenase; Lamiaceae; Plants, Medicinal; Plasmodium falciparum; Skin Neoplasms; Tumor Cells, Cultured | 2002 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Remissions of mammary adenocarcinoma in hypothyroid mice given 5-fluorouracil and chloroquine phosphate.
Topics: Adenocarcinoma; Animals; Chloroquine; Drug Therapy, Combination; Female; Fluorouracil; Hypothyroidism; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Propylthiouracil; Remission, Spontaneous | 1979 |
Fifty-five percent complete remission of mammary carcinoma in mice with 5-fluorouracil and chloroquine.
Topics: Animals; Chloroquine; Drug Therapy, Combination; Female; Fluorouracil; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Remission, Spontaneous; Time Factors | 1978 |
Treatment for AIDS and other retrovirus-caused diseases.
Topics: Acquired Immunodeficiency Syndrome; Animals; Chloroquine; Drug Therapy, Combination; Fluorouracil; Humans; Mice; Propylthiouracil | 1988 |
Chloroquine and synthesis of aminoacyl transfer ribonucleic acids. Conformational changes in tryptophanyl and tryptophan transfer ribonucleic acids.
Topics: Amino Acids; Animals; Binding Sites; Carbon Isotopes; Chemical Precipitation; Chloroquine; Chromatography; Drug Stability; Edetic Acid; Escherichia coli; Fluorouracil; Hydrogen-Ion Concentration; Hydroxyapatites; Ligases; Liver; Magnesium; Methylation; Mutation; Nucleic Acid Denaturation; Rats; RNA, Bacterial; RNA, Transfer; Saccharomyces; Silicon Dioxide; Species Specificity; Spectrophotometry; Temperature; Time Factors; Tritium; Tryptophan; Ultraviolet Rays | 1969 |
Biosynthesis of the tripyrrole bacterial pigment, prodigiosin, by nonproliferating cells of Serratia marcescens.
Topics: Amino Acids; Anti-Bacterial Agents; Carbon Isotopes; Cell Count; Chloramphenicol; Chloroquine; Cycloheximide; Dactinomycin; Fluorouracil; Kinetics; Mitomycins; Pigments, Biological; Prodigiosin; Proteins; Puromycin; Pyrroles; Serratia marcescens; Streptomycin; Temperature; Tryptophan | 1972 |
Sequential liver scanning.
Topics: Adult; Breast Neoplasms; Chloroquine; Colonic Neoplasms; Dactinomycin; Emetine; Estrogens; Female; Fluorouracil; Gold Colloid, Radioactive; Humans; Liver Abscess, Amebic; Liver Neoplasms; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Radionuclide Imaging; Thiotepa | 1969 |
Evaluation of the cytotoxicity of selected systemic and intravitreally dosed drugs in the cultures of human retinal pigment epithelial cell line and of pig primary retinal pigment epithelial cells.
Topics: Animals; Cell Division; Cell Survival; Cells, Cultured; Chloroquine; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Fluorouracil; Ganciclovir; Gentamicins; Humans; Pigment Epithelium of Eye; Species Specificity; Swine; Tamoxifen; Toremifene | 2002 |
Chloroquine treatment increases detection of 5-fluorouracil-induced apoptosis index in vivo.
Topics: Animals; Apoptosis; Bone Marrow Cells; Carcinoma, Ehrlich Tumor; Chloroquine; Drug Synergism; Fluorouracil; Male; Mice; Microscopy, Fluorescence; Radiography | 2006 |
Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells.
Topics: Antimalarials; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chloroquine; Colonic Neoplasms; Colony-Forming Units Assay; Drug Synergism; Flow Cytometry; Fluorouracil; Humans; Immunoenzyme Techniques | 2010 |
Resistance of colon cancer to 5-fluorouracil may be overcome by combination with chloroquine, an in vivo study.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chloroquine; Colonic Neoplasms; Colorectal Neoplasms; Drug Resistance, Neoplasm; Female; Fluorouracil; Mice; Mice, Inbred BALB C; Microtubule-Associated Proteins; RNA Nucleotidyltransferases; Transcription Factor TFIIH; Transcription Factors; Tumor Burden | 2012 |
Pharmacogenomic biomarkers in dermatologic drugs.
Topics: Androstenes; Aryl Hydrocarbon Hydroxylases; Biomarkers; Chloroquine; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Dapsone; Dermatologic Agents; Dihydropyrimidine Dehydrogenase Deficiency; Ethinyl Estradiol; Fluorouracil; Glucosephosphate Dehydrogenase Deficiency; Humans; Naphthalenes; Primaquine; Quinuclidines; Terbinafine; Thiophenes | 2013 |
Chloroquine enhances the chemotherapeutic activity of 5-fluorouracil in a colon cancer cell line via cell cycle alteration.
Topics: Antimalarials; Antimetabolites, Antineoplastic; Autophagy; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Survival; Chloroquine; Colonic Neoplasms; Cyclin D1; Cyclin-Dependent Kinase 2; Drug Synergism; Flow Cytometry; Fluorouracil; Humans; Microtubule-Associated Proteins; Phosphatidylinositol 3-Kinases; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53 | 2012 |
Long-term stimulation of areca nut components results in increased chemoresistance through elevated autophagic activity.
Topics: Actins; Adenine; Antimetabolites, Antineoplastic; Antineoplastic Agents; Areca; Autophagy; Autophagy-Related Proteins; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Chloroquine; Cisplatin; Cysteine Endopeptidases; Drug Resistance, Neoplasm; Fluorouracil; Glucose; Humans; Indicators and Reagents; Jurkat Cells; Microtubule-Associated Proteins; Mouth Neoplasms; Plant Extracts; Tetrazolium Salts; Time Factors | 2014 |
Autophagy is needed for the growth of pancreatic adenocarcinoma and has a cytoprotective effect against anticancer drugs.
Topics: Adenocarcinoma; Androstadienes; Antineoplastic Agents; Autophagy; Cell Line, Tumor; Cell Proliferation; Chloroquine; Deoxycytidine; Fluorouracil; Gemcitabine; Humans; Microtubule-Associated Proteins; Pancreatic Neoplasms; Protein Kinase Inhibitors; Wortmannin | 2014 |
[Effects of autophagy on 5-fluorouracil cytotoxicity for gallbladder carcinoma GBC-SD cell].
Topics: Autophagy; Cell Line, Tumor; Cell Proliferation; Chloroquine; Fluorouracil; Humans | 2014 |
Autophagy is upregulated during colorectal carcinogenesis, and in DNA microsatellite stable carcinomas.
Topics: Apoptosis; Autophagy; Bevacizumab; Carcinogenesis; Chloroquine; Colorectal Neoplasms; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Microsatellite Instability; Microsatellite Repeats; Microtubule-Associated Proteins | 2015 |
Aberrant DR5 transport through disruption of lysosomal function suggests a novel mechanism for receptor activation.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Autophagy; Cell Membrane; Chloroquine; Cholesterol; Fluorouracil; HCT116 Cells; Humans; Ligands; Lysosomes; Macrolides; Mitochondria; Phagosomes; Protein Transport; Receptors, TNF-Related Apoptosis-Inducing Ligand; RNA Interference; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Tumor Suppressor Protein p53 | 2016 |
Autophagy regulates chemoresistance of gastric cancer stem cells via the Notch signaling pathway.
Topics: Autophagy; Cell Line, Tumor; Cell Survival; Chloroquine; Drug Resistance, Neoplasm; Drug Synergism; Fluorouracil; Humans; Hyaluronan Receptors; Intercellular Adhesion Molecule-1; Microtubule-Associated Proteins; Neoplastic Stem Cells; Receptor, Notch1; Signal Transduction; Stomach Neoplasms | 2018 |
miR-874 regulates multiple-drug resistance in gastric cancer by targeting ATG16L1.
Topics: 3' Untranslated Regions; Animals; Autophagy; Autophagy-Related Proteins; Cell Line, Tumor; Chloroquine; Cisplatin; Down-Regulation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; MicroRNAs; Neoplasm Staging; Neoplasm Transplantation; Stomach Neoplasms; Vincristine | 2018 |
Supramolecular self-assembly of triazine-based small molecules: targeting the endoplasmic reticulum in cancer cells.
Topics: Chloroquine; Drug Delivery Systems; Endoplasmic Reticulum; Fluorouracil; HeLa Cells; Humans; Neoplasms; Triazines | 2019 |
Blocking drug-induced autophagy with chloroquine in HCT-116 colon cancer cells enhances DC maturation and T cell responses induced by tumor cell lysate.
Topics: Antimetabolites, Antineoplastic; Autophagy; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Differentiation; Chloroquine; Dendritic Cells; Fluorouracil; HCT116 Cells; Humans; Lymphocyte Activation; Th1 Cells; Transcriptional Activation | 2020 |
5-Fluorouracil in combination with deoxyribonucleosides and deoxyribose as possible therapeutic options for the Coronavirus, COVID-19 infection.
Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; Chloroquine; Clinical Trials as Topic; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Deoxyribonucleosides; Deoxyribose; Drug Administration Schedule; Drug Synergism; Fluorouracil; Humans; Inflammation; Models, Theoretical; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
The loss of SHMT2 mediates 5-fluorouracil chemoresistance in colorectal cancer by upregulating autophagy.
Topics: Animals; Antimalarials; Antimetabolites, Antineoplastic; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Chloroquine; Colorectal Neoplasms; Drug Resistance, Neoplasm; Female; Fluorouracil; Glycine Hydroxymethyltransferase; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Signal Transduction; Survival Rate; Xenograft Model Antitumor Assays | 2021 |
Evaluation of nanoparticles with 5-fluorouracil and chloroquine on Acanthamoeba castellanii activity.
Topics: Acanthamoeba castellanii; Acanthamoeba Keratitis; Amebicides; Chloroquine; Fluorouracil; Humans; Nanoparticles | 2022 |
Combination of Antimalarial and CNS Drugs with Antineoplastic Agents in MCF-7 Breast and HT-29 Colon Cancer Cells: Biosafety Evaluation and Mechanism of Action.
Topics: Adenosine Diphosphate; Antimalarials; Antineoplastic Agents; Artesunate; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benztropine; Breast Neoplasms; Cell Line, Tumor; Chloroquine; Colonic Neoplasms; Containment of Biohazards; Doxorubicin; Drug Resistance, Neoplasm; Female; Fluorouracil; Fluoxetine; Fluphenazine; Humans; Ki-67 Antigen; MCF-7 Cells; Michigan; NF-kappa B; Paclitaxel; Poly(ADP-ribose) Polymerase Inhibitors; Ribose; Sertraline; Thioridazine | 2022 |
Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia.
Topics: Ataxia Telangiectasia Mutated Proteins; Carcinoma; Cell Hypoxia; Cell Line, Tumor; Chloroquine; Colonic Neoplasms; Fluorouracil; Humans; Hypoxia; Vascular Endothelial Growth Factor A | 2023 |