fluorouracil and chloroquine

fluorouracil has been researched along with chloroquine in 41 studies

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-19907 (17.07)18.7374
1990's0 (0.00)18.2507
2000's11 (26.83)29.6817
2010's16 (39.02)24.3611
2020's7 (17.07)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Clark, AM; Dunbar, DC; Muhammad, I; Takamatsu, S; Walker, LA1
Busson, R; Chepkwony, H; De Witte, P; Govaerts, C; Hoogmartens, J; Hoornaert, G; Janssens, L; Kuria, KA; Laekeman, G; Maes, L; Quirynen, L; Roets, E; Zupko, I1
Lombardo, F; Obach, RS; Waters, NJ1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Dagher, RK; Shoemaker, JP1
Shoemaker, JP2
Muench, KH1
Hussain Qadri, SM; Williams, RP1
Ota, K1
Johnston, GS; Jones, AE1
Diehl, H; Engelke, M; Huhtala, A; Mäenpää, H; Mannerström, M; Mäntylä, E; Mäntylä, M; Marselos, M; Pappas, P; Salminen, L; Tähti, H; Toimela, T; Uusitalo, H; Zorn-Kruppa, M1
Feng, FY; Kanade, VD; Nayak, R; Nyati, MK1
Hiyoshi, M; Hongo, K; Kaneko, M; Kawai, K; Kitayama, J; Nagawa, H; Nishikawa, T; Okaji, Y; Sasaki, K; Shuno, Y; Sunami, E; Takahashi, K; Tsuno, NH; Tsurita, G1
Hiyoshi, M; Hongo, K; Kaneko, M; Kawai, K; Kitayama, J; Murono, K; Nirei, T; Sasaki, K; Sunami, E; Tada, N; Takahashi, K; Tsuno, NH1
Greenfield, NP; Maibach, H1
Choi, JH; Lee, YY; Park, BB; Won, YW; Yoon, JS1
Cheng, PC; Chiang, WF; Hong, WZ; Lee, SY; Lin, MH; Lin, PY; Liu, SY; Liu, YC; Yen, CY1
Bläuer, M; Hashimoto, D; Hirota, M; Ikonen, NH; Laukkarinen, J; Sand, J1
Cai, X; Liang, X; Liu, J; Liu, X; Ma, R; Tang, J1
Benincasa, M; Magnani, G; Mancini, S; Mariani, F; Palumbo, C; Pedroni, M; Roncucci, L; Sena, P1
Akpinar, B; Debnath, S; Laukova, J; Olsson, M; Safarikova, B; Vaculova, AH; Zhivotovsky, B1
-Y-Xie, D; Chen, H; Li, LQ; Pan, D; Zhang, SW; Zheng, XL1
Bu, Y; Huang, H; Tang, J; Zhang, L; Zhang, X1
Basu, S; Ghosh, C; Nandi, A1
Dos Santos, DC; Falasco, BF; Gorgulho, CM; Junior, JPA; Kaneno, R; Lotze, MT; Romagnoli, GG; Sanzochi Fogolin, C; Ureshino, RP; Zamame Ramirez, JA1
Ahmad, SI1
Chen, C; Chen, J; Fan, G; Liu, X; Lu, H; Na, R; Peng, Z; Song, G; Tang, H; Wang, X; Wang, Y; Xiao, C; Yan, D; Zhuang, G1
Islam, MK; Lian, HK; Lim, JCW; Sagineedu, SR; Selvarajoo, N; Stanslas, J1
Adrees, AO; Akbar, N; Al-Shahrabi, R; Khan, NA; Manzoor, S; Muhammad, JS; Qalaji, MR; Roberta, C; Saeed, BQ; Siddiqui, R1
Duarte, D; Nunes, M; Ricardo, S; Vale, N1
Ju, S; Jung, Y; Kang, C; Kim, J1

Reviews

3 review(s) available for fluorouracil and chloroquine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Multiple combination therapy in cancer chemotherapy in Japan.
    Gan, 1969, Volume: 60, Issue:3

    Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Chloroquine; Cyclophosphamide; Cytarabine; Drug Synergism; Fluorouracil; Humans; Japan; Leukemia; Lymphoma; Mercaptopurine; Mitomycins; Neoplasms; Podophyllin; Prednisolone; Thiotepa; Vincristine; Vitamin K 1

1969
Pharmacological Modulation of Apoptosis and Autophagy in Pancreatic Cancer Treatment.
    Mini reviews in medicinal chemistry, 2022, Volume: 22, Issue:20

    Topics: Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Chloroquine; ErbB Receptors; Fluorouracil; Humans; Metformin; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Resveratrol; Sirolimus; TOR Serine-Threonine Kinases

2022

Other Studies

38 other study(ies) available for fluorouracil and chloroquine

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Antimalarial, cytotoxic, and antifungal alkaloids from Duguetia hadrantha.
    Journal of natural products, 2001, Volume: 64, Issue:5

    Topics: Alkaloids; Animals; Antifungal Agents; Antimalarials; Antineoplastic Agents, Phytogenic; Brazil; Cell Adhesion; Cell Aggregation; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Paraguay; Plant Extracts; Plants, Medicinal; Plasmodium falciparum; Spectrophotometry, Ultraviolet; Tumor Cells, Cultured

2001
The antiplasmodial activity of isolates from Ajuga remota.
    Journal of natural products, 2002, Volume: 65, Issue:5

    Topics: Animals; Antimalarials; Antineoplastic Agents; Chloroquine; Chromatography, Thin Layer; Diterpenes; Drug Resistance, Microbial; Drug Screening Assays, Antitumor; Ergosterol; Fluorouracil; Humans; In Vitro Techniques; Inhibitory Concentration 50; Kenya; L-Lactate Dehydrogenase; Lamiaceae; Plants, Medicinal; Plasmodium falciparum; Skin Neoplasms; Tumor Cells, Cultured

2002
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
    Nature chemical biology, 2009, Volume: 5, Issue:10

    Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Remissions of mammary adenocarcinoma in hypothyroid mice given 5-fluorouracil and chloroquine phosphate.
    Journal of the National Cancer Institute, 1979, Volume: 62, Issue:6

    Topics: Adenocarcinoma; Animals; Chloroquine; Drug Therapy, Combination; Female; Fluorouracil; Hypothyroidism; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Propylthiouracil; Remission, Spontaneous

1979
Fifty-five percent complete remission of mammary carcinoma in mice with 5-fluorouracil and chloroquine.
    Cancer research, 1978, Volume: 38, Issue:9

    Topics: Animals; Chloroquine; Drug Therapy, Combination; Female; Fluorouracil; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Remission, Spontaneous; Time Factors

1978
Treatment for AIDS and other retrovirus-caused diseases.
    Medical hypotheses, 1988, Volume: 27, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Animals; Chloroquine; Drug Therapy, Combination; Fluorouracil; Humans; Mice; Propylthiouracil

1988
Chloroquine and synthesis of aminoacyl transfer ribonucleic acids. Conformational changes in tryptophanyl and tryptophan transfer ribonucleic acids.
    Biochemistry, 1969, Volume: 8, Issue:12

    Topics: Amino Acids; Animals; Binding Sites; Carbon Isotopes; Chemical Precipitation; Chloroquine; Chromatography; Drug Stability; Edetic Acid; Escherichia coli; Fluorouracil; Hydrogen-Ion Concentration; Hydroxyapatites; Ligases; Liver; Magnesium; Methylation; Mutation; Nucleic Acid Denaturation; Rats; RNA, Bacterial; RNA, Transfer; Saccharomyces; Silicon Dioxide; Species Specificity; Spectrophotometry; Temperature; Time Factors; Tritium; Tryptophan; Ultraviolet Rays

1969
Biosynthesis of the tripyrrole bacterial pigment, prodigiosin, by nonproliferating cells of Serratia marcescens.
    Texas reports on biology and medicine, 1972,Spring, Volume: 30, Issue:1

    Topics: Amino Acids; Anti-Bacterial Agents; Carbon Isotopes; Cell Count; Chloramphenicol; Chloroquine; Cycloheximide; Dactinomycin; Fluorouracil; Kinetics; Mitomycins; Pigments, Biological; Prodigiosin; Proteins; Puromycin; Pyrroles; Serratia marcescens; Streptomycin; Temperature; Tryptophan

1972
Sequential liver scanning.
    Journal of surgical oncology, 1969, Volume: 1, Issue:3

    Topics: Adult; Breast Neoplasms; Chloroquine; Colonic Neoplasms; Dactinomycin; Emetine; Estrogens; Female; Fluorouracil; Gold Colloid, Radioactive; Humans; Liver Abscess, Amebic; Liver Neoplasms; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Radionuclide Imaging; Thiotepa

1969
Evaluation of the cytotoxicity of selected systemic and intravitreally dosed drugs in the cultures of human retinal pigment epithelial cell line and of pig primary retinal pigment epithelial cells.
    Toxicology in vitro : an international journal published in association with BIBRA, 2002, Volume: 16, Issue:2

    Topics: Animals; Cell Division; Cell Survival; Cells, Cultured; Chloroquine; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Fluorouracil; Ganciclovir; Gentamicins; Humans; Pigment Epithelium of Eye; Species Specificity; Swine; Tamoxifen; Toremifene

2002
Chloroquine treatment increases detection of 5-fluorouracil-induced apoptosis index in vivo.
    Molecular imaging, 2006, Volume: 5, Issue:3

    Topics: Animals; Apoptosis; Bone Marrow Cells; Carcinoma, Ehrlich Tumor; Chloroquine; Drug Synergism; Fluorouracil; Male; Mice; Microscopy, Fluorescence; Radiography

2006
Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells.
    BMC cancer, 2010, Jul-15, Volume: 10

    Topics: Antimalarials; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chloroquine; Colonic Neoplasms; Colony-Forming Units Assay; Drug Synergism; Flow Cytometry; Fluorouracil; Humans; Immunoenzyme Techniques

2010
Resistance of colon cancer to 5-fluorouracil may be overcome by combination with chloroquine, an in vivo study.
    Anti-cancer drugs, 2012, Volume: 23, Issue:7

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chloroquine; Colonic Neoplasms; Colorectal Neoplasms; Drug Resistance, Neoplasm; Female; Fluorouracil; Mice; Mice, Inbred BALB C; Microtubule-Associated Proteins; RNA Nucleotidyltransferases; Transcription Factor TFIIH; Transcription Factors; Tumor Burden

2012
Pharmacogenomic biomarkers in dermatologic drugs.
    The Journal of dermatological treatment, 2013, Volume: 24, Issue:6

    Topics: Androstenes; Aryl Hydrocarbon Hydroxylases; Biomarkers; Chloroquine; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Dapsone; Dermatologic Agents; Dihydropyrimidine Dehydrogenase Deficiency; Ethinyl Estradiol; Fluorouracil; Glucosephosphate Dehydrogenase Deficiency; Humans; Naphthalenes; Primaquine; Quinuclidines; Terbinafine; Thiophenes

2013
Chloroquine enhances the chemotherapeutic activity of 5-fluorouracil in a colon cancer cell line via cell cycle alteration.
    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 2012, Volume: 120, Issue:7

    Topics: Antimalarials; Antimetabolites, Antineoplastic; Autophagy; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Survival; Chloroquine; Colonic Neoplasms; Cyclin D1; Cyclin-Dependent Kinase 2; Drug Synergism; Flow Cytometry; Fluorouracil; Humans; Microtubule-Associated Proteins; Phosphatidylinositol 3-Kinases; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53

2012
Long-term stimulation of areca nut components results in increased chemoresistance through elevated autophagic activity.
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2014, Volume: 43, Issue:2

    Topics: Actins; Adenine; Antimetabolites, Antineoplastic; Antineoplastic Agents; Areca; Autophagy; Autophagy-Related Proteins; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Chloroquine; Cisplatin; Cysteine Endopeptidases; Drug Resistance, Neoplasm; Fluorouracil; Glucose; Humans; Indicators and Reagents; Jurkat Cells; Microtubule-Associated Proteins; Mouth Neoplasms; Plant Extracts; Tetrazolium Salts; Time Factors

2014
Autophagy is needed for the growth of pancreatic adenocarcinoma and has a cytoprotective effect against anticancer drugs.
    European journal of cancer (Oxford, England : 1990), 2014, Volume: 50, Issue:7

    Topics: Adenocarcinoma; Androstadienes; Antineoplastic Agents; Autophagy; Cell Line, Tumor; Cell Proliferation; Chloroquine; Deoxycytidine; Fluorouracil; Gemcitabine; Humans; Microtubule-Associated Proteins; Pancreatic Neoplasms; Protein Kinase Inhibitors; Wortmannin

2014
[Effects of autophagy on 5-fluorouracil cytotoxicity for gallbladder carcinoma GBC-SD cell].
    Zhonghua yi xue za zhi, 2014, Mar-04, Volume: 94, Issue:8

    Topics: Autophagy; Cell Line, Tumor; Cell Proliferation; Chloroquine; Fluorouracil; Humans

2014
Autophagy is upregulated during colorectal carcinogenesis, and in DNA microsatellite stable carcinomas.
    Oncology reports, 2015, Volume: 34, Issue:6

    Topics: Apoptosis; Autophagy; Bevacizumab; Carcinogenesis; Chloroquine; Colorectal Neoplasms; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Microsatellite Instability; Microsatellite Repeats; Microtubule-Associated Proteins

2015
Aberrant DR5 transport through disruption of lysosomal function suggests a novel mechanism for receptor activation.
    Oncotarget, 2016, Sep-06, Volume: 7, Issue:36

    Topics: Antimetabolites, Antineoplastic; Apoptosis; Autophagy; Cell Membrane; Chloroquine; Cholesterol; Fluorouracil; HCT116 Cells; Humans; Ligands; Lysosomes; Macrolides; Mitochondria; Phagosomes; Protein Transport; Receptors, TNF-Related Apoptosis-Inducing Ligand; RNA Interference; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Tumor Suppressor Protein p53

2016
Autophagy regulates chemoresistance of gastric cancer stem cells via the Notch signaling pathway.
    European review for medical and pharmacological sciences, 2018, Volume: 22, Issue:11

    Topics: Autophagy; Cell Line, Tumor; Cell Survival; Chloroquine; Drug Resistance, Neoplasm; Drug Synergism; Fluorouracil; Humans; Hyaluronan Receptors; Intercellular Adhesion Molecule-1; Microtubule-Associated Proteins; Neoplastic Stem Cells; Receptor, Notch1; Signal Transduction; Stomach Neoplasms

2018
miR-874 regulates multiple-drug resistance in gastric cancer by targeting ATG16L1.
    International journal of oncology, 2018, Volume: 53, Issue:6

    Topics: 3' Untranslated Regions; Animals; Autophagy; Autophagy-Related Proteins; Cell Line, Tumor; Chloroquine; Cisplatin; Down-Regulation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; MicroRNAs; Neoplasm Staging; Neoplasm Transplantation; Stomach Neoplasms; Vincristine

2018
Supramolecular self-assembly of triazine-based small molecules: targeting the endoplasmic reticulum in cancer cells.
    Nanoscale, 2019, Feb-14, Volume: 11, Issue:7

    Topics: Chloroquine; Drug Delivery Systems; Endoplasmic Reticulum; Fluorouracil; HeLa Cells; Humans; Neoplasms; Triazines

2019
Blocking drug-induced autophagy with chloroquine in HCT-116 colon cancer cells enhances DC maturation and T cell responses induced by tumor cell lysate.
    International immunopharmacology, 2020, Volume: 84

    Topics: Antimetabolites, Antineoplastic; Autophagy; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Differentiation; Chloroquine; Dendritic Cells; Fluorouracil; HCT116 Cells; Humans; Lymphocyte Activation; Th1 Cells; Transcriptional Activation

2020
5-Fluorouracil in combination with deoxyribonucleosides and deoxyribose as possible therapeutic options for the Coronavirus, COVID-19 infection.
    Medical hypotheses, 2020, Volume: 142

    Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; Chloroquine; Clinical Trials as Topic; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Deoxyribonucleosides; Deoxyribose; Drug Administration Schedule; Drug Synergism; Fluorouracil; Humans; Inflammation; Models, Theoretical; Pandemics; Pneumonia, Viral; SARS-CoV-2

2020
The loss of SHMT2 mediates 5-fluorouracil chemoresistance in colorectal cancer by upregulating autophagy.
    Oncogene, 2021, Volume: 40, Issue:23

    Topics: Animals; Antimalarials; Antimetabolites, Antineoplastic; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Chloroquine; Colorectal Neoplasms; Drug Resistance, Neoplasm; Female; Fluorouracil; Glycine Hydroxymethyltransferase; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Signal Transduction; Survival Rate; Xenograft Model Antitumor Assays

2021
Evaluation of nanoparticles with 5-fluorouracil and chloroquine on Acanthamoeba castellanii activity.
    Molecular and biochemical parasitology, 2022, Volume: 250

    Topics: Acanthamoeba castellanii; Acanthamoeba Keratitis; Amebicides; Chloroquine; Fluorouracil; Humans; Nanoparticles

2022
Combination of Antimalarial and CNS Drugs with Antineoplastic Agents in MCF-7 Breast and HT-29 Colon Cancer Cells: Biosafety Evaluation and Mechanism of Action.
    Biomolecules, 2022, Oct-16, Volume: 12, Issue:10

    Topics: Adenosine Diphosphate; Antimalarials; Antineoplastic Agents; Artesunate; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benztropine; Breast Neoplasms; Cell Line, Tumor; Chloroquine; Colonic Neoplasms; Containment of Biohazards; Doxorubicin; Drug Resistance, Neoplasm; Female; Fluorouracil; Fluoxetine; Fluphenazine; Humans; Ki-67 Antigen; MCF-7 Cells; Michigan; NF-kappa B; Paclitaxel; Poly(ADP-ribose) Polymerase Inhibitors; Ribose; Sertraline; Thioridazine

2022
Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia.
    Pharmacological reports : PR, 2023, Volume: 75, Issue:1

    Topics: Ataxia Telangiectasia Mutated Proteins; Carcinoma; Cell Hypoxia; Cell Line, Tumor; Chloroquine; Colonic Neoplasms; Fluorouracil; Humans; Hypoxia; Vascular Endothelial Growth Factor A

2023