fluorouracil has been researched along with chitosan in 185 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (0.54) | 18.2507 |
| 2000's | 25 (13.51) | 29.6817 |
| 2010's | 102 (55.14) | 24.3611 |
| 2020's | 57 (30.81) | 2.80 |
| Authors | Studies |
|---|---|
| Kimura, Y; Okuda, H | 1 |
| Harding, DR; Shantha, KL | 1 |
| Machida, Y; Nagai, T; Onishi, H; Yoshino, T | 1 |
| Calis, S; Fredro-Kumbaradzi, E; Glavas-Dodov, M; Goracinova, K; Hincal, AA; Simonoska, M | 1 |
| Dubey, RR; Parikh, RH | 1 |
| Wu, FL; Yu, SY; Zhao, Y; Zheng, AP | 1 |
| Aksungur, P; Iskit, AB; Senel, S; Squier, CA; Sungur, A; Unal, S | 1 |
| Babita, K; Gorea, R; Goyal, D; Rana, V; Tiwary, A | 1 |
| Babita, K; Goyal, D; Rana, V; Tiwary, A | 1 |
| Agnihotri, SA; Aminabhavi, TM | 1 |
| Chen, D; Gu, J; Qin, J; Yan, C | 1 |
| Chen, Q; Lin, Y; Luo, H | 1 |
| Chang, SJ; Chen, SF; Kuo, SM; Niu, GC | 1 |
| Aminabhavi, TM; Patil, SA; Rokhade, AP; Shelke, NB | 1 |
| Dong, L; Fu, S; Hu, J; Shen, X; Wang, C; Wu, L; Yang, W; Zheng, Y | 1 |
| Ando, M; Danjo, K; Okamoto, H; Ozeki, Y; Sakurai, M | 1 |
| Cheng, SX; Yu, CY; Zhang, XC; Zhang, XZ; Zhou, FZ; Zhuo, RX | 1 |
| Dong, L; Shen, XZ; Wang, JY; Wu, LL; Zhang, DY; Zheng, YL | 1 |
| Chen, DW; Li, KX; Pang, DH; Zhao, XF; Zhao, XL | 1 |
| Jain, A; Jain, SK | 2 |
| Jia, N; Ma, J; Shen, H; Zhao, Y; Zhu, L | 1 |
| Han, J; Nie, J; Wang, K; Yang, D | 1 |
| Fu, CH; Lin, CC | 1 |
| Araki, H; Hidaka, N; Sakanaka, M; Suemaru, K; Watanabe, S; Yamaguchi, T | 1 |
| Calis, S; Crcarevska, MS; Geskovski, N; Glavas Dodov, M; Goracinova, K; Petrovska, V | 1 |
| Al-Mohizea, AM; Al-Obeed, OA; Al-Robayan, AA; Alanazi, FK; Alsarra, IA; Yassin, AE | 1 |
| Chung, TW; Lin, SY; Liu, DZ; Tyan, YC; Yang, JS | 1 |
| Chen, D; Gu, J; Guo, Y; Yan, C | 1 |
| Gao, F; Gao, Y; Gu, L; Sun, Y | 1 |
| El-Sherbiny, IM; Smyth, HD | 1 |
| Rana, V; Tiwary, AK | 1 |
| CAI, X; CHEN, RF; CHENG, LZ; FAN, JZ; GUO, H; LAN, YQ; YANG, LQ; ZHANG, LM; ZHOU, HS | 1 |
| Chen, X; Wang, Z; Yan, S; Yin, J; Zheng, Y; Zhu, J | 1 |
| Kant, S; Maiti, P; Nagarwal, RC; Pandit, JK; Singh, PN | 2 |
| Lin, YS; Minami, S; Morimoto, M; Okamoto, Y; Radzi, R; Saimoto, H | 1 |
| Bajaj, HC; Brahmbhatt, H; Gadhia, PK; Jena, PK; Jhala, DD; Joshi, GV; Kevadiya, BD; Pandya, MP; Patel, TA; Rajkumar, S; Thumbar, RP; Tripathi, CB | 1 |
| Chen, X; Duan, Y; Rao, S; Wang, Z; Yan, S; Yin, J; Zhang, Y; Zhu, J | 1 |
| Rai, PR; Rana, V; Tiwary, AK | 1 |
| Cheng, GY; Cheng, SY; Chui, CH; Gambari, R; Kok, SH; Lam, KH; Lam, PL; Lee, KK; Wong, RS; Yuen, MC | 1 |
| Sangeetha, D; Sundar, SS | 1 |
| Anitha, A; Chennazhi, KP; Jayakumar, R; Nair, SV | 1 |
| Cheng, M; Han, J; He, B; Hou, Y; Li, Q; Wang, W; Wu, J; Xu, H; Ye, T; Zha, B; Zhou, R | 1 |
| Kumar, R; Nagarwal, RC; Pandit, JK | 1 |
| Chen, H; Cheng, M; Han, J; He, B; Li, Q; Liu, Z; Wan, T; Wang, W; Xu, H; Yang, F; Ye, T; Zha, B | 1 |
| Chen, H; Guo, L; Li, G; Zhang, T | 1 |
| Chen, HX; Cheng, MR; Han, J; He, B; Li, Q; Wan, T; Wang, W; Xu, HZ; Yang, FX; Ye, T; Zha, BB | 1 |
| Guo, L; Li, G; Wen, Q; Zhang, T | 1 |
| Cai, JP; Cheng, JW; Huang, X; Li, Y; Ma, XY; Wang, Y; Wei, RL | 1 |
| Kong, L; Li, P; Wang, Y | 1 |
| Chen, D; Han, S; Lu, W; Qin, F; Tan, H; Yao, X | 1 |
| Crcarevska, MS; Dimchevska, S; Geskovski, N; Glavas-Dodov, M; Goracinova, K; Kuzmanovska, S; Steffansen, B | 1 |
| Aydemir Sezer, U; Deliloglu Gurhan, İ; Gulce İz, S; Hasirci, N; Ozerkan, T | 1 |
| Al-Arfaj, AA; Murugan, AM; Raj, V; Rajan, M | 1 |
| Alvarez-Lorenzo, C; Concheiro, A; Lima, AC; Mano, JF; Puga, AM | 1 |
| Li, G; Liu, J; Qi, M; Song, S; Zhang, T | 1 |
| Chen, H; Cheng, M; Gao, X; Han, J; He, B; Li, Y; Wang, Y; Xu, H; Zhang, Z | 2 |
| Ebrahimi, P; Hadianamrei, R; Honary, S | 1 |
| Depani, BP; Naik, AA; Nair, HA | 1 |
| Gao, QH; He, YX; Li, HL; Wu, GZ | 1 |
| Chen, H; Cheng, M; Han, J; He, B; Wang, Y; Xu, H; Zhang, Z | 1 |
| Cavalli, R; Dianzani, C; Fantozzi, R; Leone, F; Minelli, R | 1 |
| Gu, CH; Lang, MD; Le, VM; Liu, JW; Lu, YH; Shi, WB; Zheng, YH | 1 |
| Gu, C; Lang, M; Le, V; Liu, J | 1 |
| Duan, W; Kong, LX; Li, PW; Peng, Z; Wang, G; Wang, QH; Yang, ZM | 1 |
| Anitha, A; Chennazhi, KP; Jayakumar, R; Lakshmanan, VK; Sreeranganathan, M | 1 |
| Anitha, A; Chennazhi, KP; Deepa, N; Jayakumar, R; Lakshmanan, VK | 1 |
| Çakmak, AS; Gümüşderelioğlu, M; Kutlu, C | 1 |
| Hernández, R; Kumacheva, E; Mijangos, C; Velasco, D; Zamora-Mora, V | 1 |
| Li, YK; Wang, CQ; Wang, L; Xu, Y | 1 |
| Ding, Y; Liu, F; Qi, Y; Shen, SZ; Sun, H; Sun, K; Yan, J | 1 |
| Atyabi, F; Dinarvand, R; Esfandyari-Manesh, M; Ghasemi, Z; Mottaghitalab, F; Sayari, E | 1 |
| Baigude, H; Gao, X; Hai, X; Li, Z; Shen, B; Su, H; Tan, Z; Yu, S; Zhang, R | 1 |
| Chang, G; Chen, Y; Huang, F; Li, S; Li, Y; Shen, Y; Xie, A | 1 |
| Benito-Miguel, M; Blanco, MD; Gómez, C | 1 |
| David, KI; Jaidev, LR; Krishnan, UM; Sethuraman, S | 1 |
| Lian, Q; Wang, X; Yang, H; Zheng, XF | 1 |
| Budriene, S; Di Martino, A; Maciulyte, S; Pavelkova, A; Sedlarik, V | 1 |
| A, R; A, S; E A K, N; S, D; V, N | 1 |
| Alupei, L; Chiscan, O; Desbrieres, J; Lungan, AM; Peptu, CA; Popa, M; Radji, S | 1 |
| Chen, Y; Fan, J; Fu, SZ; Wang, SS; Wu, JB; Xu, S; Yang, JP; Yang, LL; Yun, Q | 1 |
| Krause, RW; Lakkakula, JR; Matshaya, T | 1 |
| A, S; E A K, N; Narayanan, V; S, D | 1 |
| Baigude, H; Gao, X; Guan, W; Hai, X; Liu, Z | 1 |
| Badran, MM; Ghannam, MM; Mady, MM; Shakeel, F | 1 |
| Fernández-Gutiérrez, M; González-Gómez, Á; Goya, GF; Hernández, R; Mijangos, C; Román, JS; Sanz, B; Zamora-Mora, V | 1 |
| Nawaz, A; Wong, TW | 2 |
| Hou, J; Shi, Y; Su, C; Wang, T; Zhao, L | 1 |
| Azuma, K; Ifuku, S; Imagawa, T; Ito, N; Izawa, H; Koizumi, R; Morimoto, M; Ochi, K; Okamoto, Y; Osaki, T; Saimoto, H; Tsuka, T | 1 |
| Bizzarri, R; Fabiano, A; Zambito, Y | 1 |
| Gao, P; He, DX; Huang, C; Huang, W; Li, NM; Li, ZP; Ning, Q; Tan, XW; Xiang, L; Yang, S; Ye, PJ; Yu, CY | 1 |
| Han, SS; Kumar, A; Madhusudana Rao, K | 1 |
| Iyer, AK; Jain, S; Kashaw, SK; Sahu, P; Sau, S | 1 |
| Capakova, Z; Di Martino, A; Humpolicek, P; Kucharczyk, P; Sedlarik, V | 1 |
| Bashir, S; Naeem, S; Ramesh, K; Ramesh, S; Teo, YY | 1 |
| Bafkary, R; Khoee, S; Saadatinia, A | 1 |
| Abba, Y; Abdullah, J; Abu, N; Alitheen, NB; Birma Bwatanglang, I; Elyani Mohammed, N; Mohammad, F; Nordin, N; Rizi Zamberi, N; Yusof, NA; Zubir Hussein, M | 1 |
| Elgendy, H; Elhawary, S; Kamel, KM; Khalil, IA; Rateb, ME | 1 |
| Ahmad, M; Khan, S; Kousar, M; Sharif, QU; Sohail, M; Usman Minhas, M | 1 |
| Antoniraj, MG; Ayyavu, M; Henry, LJK; Kandasamy, R; Nageshwar Rao, G; Natesan, S; Sundar, DS | 1 |
| Cheung, PCK; Qiu, WY; Wang, YY; Wu, LX; Yan, JK | 1 |
| Gao, Z; Li, Z; Wang, P; Yan, J | 1 |
| Basargan, T; Erdol-Aydin, N; Nasun-Saygili, G | 1 |
| A, S; Ayyavu, M; Kandasamy, R; M, GA; S, AT | 1 |
| Chen, W; Chen, Y; Guo, D; Sun, L; Wu, Z | 1 |
| Haj, NQ; Hussain, KS; Mohammed, MO | 1 |
| Ailincai, D; Marin, L; Tartau Mititelu, L | 1 |
| Kamiki, Y; Makino, K; Takeuchi, I | 1 |
| Ba, H; Huang, P; Li, W; Yang, X; Zheng, A | 1 |
| Cheng, M; Liu, B; Ma, D; Zhi, K; Zhu, W | 1 |
| Das, S; Horo, H; Kundu, LM; Mandal, B | 1 |
| Jiang, X; Liu, C; Lu, W; Omer, AM; Ouyang, XK; Sun, X; Wu, H; Yu, D; Zhang, S | 1 |
| Akhtar, N; Badshah, SF; Khan, S; Minhas, MU | 1 |
| Gao, P; He, DX; Li, ZP; Liu, YF; Ning, Q; Tang, SS; Tang, SY; Wei, H; Ye, PJ; Yu, CY | 1 |
| Hu, X; Li, W; Liu, T; Nie, Y; Song, K; Wang, H; Wang, S; Xing, Y | 1 |
| Patel, G; Yadav, BKN | 2 |
| Amanlou, M; Bigdeli, B; Dehghani, S; Goliaei, B; Hosseini, M; Khoobi, M; Lotfabadi, A; Naeimi, H; Nejadshafiee, V; Nezamtaheri, MS; Sadighi, A; Sharifzadeh, M | 1 |
| Liu, C; Omer, AM; Ouyang, XK; Sun, X; Yang, LY | 1 |
| Boloursaz, LA; Habibi Jouybari, M; Hosseini, S; Irani, M; Mahboobnia, K; Moradi, M | 1 |
| Chen, X; Fan, M; Hu, X; Jia, Y; Li, J; Niu, X; Ren, B; Tan, H; Xing, X; Xiong, D; Yuan, G | 1 |
| Huang, C; Huang, K; Li, X; Shao, W; Wang, F; Yao, D; Zhang, Q | 1 |
| Ahmad, Z; Chang, MW; Fan, J; Yao, Y; Zheng, Y; Zhu, LF | 1 |
| Ahmad, M; Khan, WS; Sethi, A | 1 |
| Jia, J; Niu, X; Song, Q; Sun, L; Wang, L; Zhang, H; Zhang, Y; Zhang, Z; Zhao, H; Zheng, C | 1 |
| Abukhadra, MR; El-Sherbeeny, AM; Elmeligy, MA; Mostafa, AM; Refay, NM | 1 |
| Fard, MM; Hassanzadeh, F; Mirian, M; Varshosaz, J | 1 |
| Akrami, M; Davaran, S; Farboudi, A; Irani, M; Nouri, A; Shirinzad, S; Sojoudi, P | 1 |
| Huang, K; Li, J; Tang, X; Wang, F; Wang, K; Zhang, K; Zhang, Q | 1 |
| Chen, Y; Chu, M; Fu, K; Guo, Y; Han, P; Li, W; Liu, Y; Zhu, F | 1 |
| Kavitha, T; Pattamaprom, C; Ranganathan, P; Rwei, SP; Sarojini, P; Vishnu S K, D | 1 |
| A, S; B S, L; E A K, N; Frank-Kamenetskaya, OV; J, RR; Martin, CA; Radhakrishnan, S; S, B; S, NK; V, N | 1 |
| Chen, L; Huang, K; Li, J; Tang, X; Wang, F | 1 |
| Chen, B; He, T; Liang, Q; Wang, J; Wang, W | 1 |
| Abd El-Alim, SH; Amin, A; Ayoub, MMH; Rabia, AEG; Samy, M | 1 |
| Dhinasekaran, D; Prakasarao, A; Purushothaman, B; Raj, R; Rajendran, AR; Singaravelu, G; Subramanian, B | 1 |
| Kim, YC; Park, J | 1 |
| Mohammed, AM; Osman, SK; Saleh, KI; Samy, AM | 1 |
| Aoki, S; Ayyanaar, S; Balachandran, C; Bhaskar, RC; Kesavan, MP; Raja, RP; Rajagopal, G; Rajesh, J; Webster, TJ | 1 |
| Kumar, P; Musalli, AH; Roy, P; Talukdar, PD; Wong, TW | 1 |
| Dusane, AC; Indukuri, VV; Janardhanam, LSL; Venuganti, VVK; Verma, P | 1 |
| He, DX; Huang, C; Huang, W; Liu, Y; Long, J; Tan, XW; Tang, S; Wei, H; Xiang, Y; Yu, CY; Zhou, Y | 1 |
| Shen, Y; Wang, P; Zhao, L | 1 |
| Dellali, KZ; Djennad, M; Gherghel, D; Ouagued, A; Popa, M; Rata, DM | 1 |
| Musa, N; Wong, TW | 1 |
| Chen, H; Cheng, Y; Li, X; Shi, X; Tan, W; Tan, Z; Wang, J; Wang, X | 1 |
| Moradi, A; Omidi, M; Pourmadadi, M; Yazdian, F; Zavareh, HS | 1 |
| Abdelaal, MY; Al Shanqiti, EM; Alfooty, KO | 1 |
| Akhter, DT; Bell, C; Dos Santos, AM; Fletcher, N; Gremião, MPD; Houston, ZH; Meneguin, AB; Thurecht, KJ | 1 |
| Fu, J; Houzong, R; Kong, X; Ma, Y; Shao, K; Shi, J; Wang, L | 1 |
| Alaoui-Jamali, MA; Bijian, K; Bonan, PRF; Castellano, LRC; da Cruz Perez, DE; da Silva, SD; de Lima, JM; de Medeiros, ES; Hier, M | 1 |
| Elbarbary, AM; Ghobashy, MM; Hegazy, DE | 1 |
| Cheng, MM; Guo, ZW; Li, DQ; Li, J; Meng, YJ; Wang, SY | 1 |
| Han, Y; Lin, Q; Liu, S; Wang, Y; Zhao, X | 1 |
| Ahmad, M; Ahmad, W; Huma, T; Sethi, A | 1 |
| Chen, C; Hu, S; Huang, K; Li, J; Qi, H; Wang, F | 1 |
| Gonsalves, A; Le, D; Menon, JU; Nguyen, KT; Tambe, P; Thakore, D; Wadajkar, AS; Yang, J | 1 |
| Hongsa, N; Luesakul, U; Muangsin, N; Sansanaphongpricha, K; Thinbanmai, T | 1 |
| Das, H; Horo, H; Kundu, LM; Mandal, B; Saha, M | 1 |
| Amini-Fazl, MS; Kheiri, K; Mohammadi, R; Sohrabi, N | 1 |
| Huang, D; Li, J; Liang, L; Liu, J; Lu, Y; Shen, G; Xuan, Z; Yao, W; Zhang, C | 1 |
| Behbood, L; Ebrahimi, S; Jalilian, F; Janfaza, S; Limoee, M; Pourmanouchehri, Z; Vosoughi, A | 1 |
| Chauhan, S; Kumar Pandey, S; Preet, S; Rana, K | 1 |
| Cen, J; Dong, J; Huang, J; Huang, K; Liang, Y; Lu, X; Pan, Y; Shu, G; Ye, S; Ye, W; Zhang, J; Zheng, Z; Zhou, M | 1 |
| Saravanakumar, K; Sathiyaseelan, A; Wang, MH | 1 |
| Boddu, A; Lai, WF; Obireddy, SR; Rao, KSVK; Zhang, D | 1 |
| Ajalli, N; Díez-Pascual, AM; Navaei-Nigjeh, M; Pourmadadi, M; Rashedi, H; Yazdian, F | 1 |
| Ali, A; Basit, A; Jan, N; Khan, MM; Khan, S; Madni, A; Rai, N; Shafiq, A; Shah, H | 1 |
| Far, BF; Naimi-Jamal, MR; Omrani, M | 1 |
| Jiang, MC; Li, S; Liu, HB; Wang, D; Wang, JQ; Wei, H; Yu, CY; Zheng, Z | 1 |
| Alhajlah, S; AlOmeir, O; Alrouji, M; Chellappan, DK; Chitranshi, N; Dua, K; Gulati, M; Gupta, G; Gupta, VK; Khursheed, R; Kumar, A; Kumar, B; Loebenberg, R; Morris, A; Parveen, SR; Saini, S; Sharma, DS; Singh, SK; Vishwas, S; Wadhwa, S; Zacconi, F | 1 |
| Haeri, A; Kamalinejad, M; Mortazavi, SA; Rabbani, S; Vaezi, H | 1 |
| Di Luca, M; Ioannou, N; Lamprou, DA; Luo, J; Mathew, E; Qin, M; Tagalakis, AD; Yu-Wai-Man, C | 1 |
| El-Mazaly, MH; Hanna, DH; Mohamed, RR | 1 |
| Abdullah, NH; Ali, RR; Jie, CJ; Kia, P; Lee-Kiun, MS; Moeini, H; Shameli, K; Teow, SY; Yusefi, M | 1 |
| Alhowyan, AA; Alkholief, M; Almomen, AA; Alshamsan, A; El-Toni, AM; Iqbal, M; Kalam, MA; Raish, M | 1 |
| Khozemy, EE; Mahmoud, GA; Nasef, SM | 1 |
| Abazari, M; Ahmed, MM; Ameen, MSM; Badeleh, SM; Mohammed, SS; Rostamizadeh, K | 1 |
| Barredo-Vacchelli, GR; Birocco, AM; Blachman, A; Calabrese, GC; Camperi, SA; Cenci, G; Curcio, S; Gianvincenzo, PD; Moya, S; Rodriguez, JA; Sosnik, A | 1 |
| Abukhadra, MR; Allam, AA; Alqahtani, MD; AlZahrani, SA; Bellucci, S; Bin Jumah, MN | 1 |
| Mazandarani, A; Mohammadnejad, J; Taravati, A; Yazdian, F | 1 |
| Bhattacharya, S; Page, A; Sharma, S; Shinde, P | 1 |
1 trial(s) available for fluorouracil and chitosan
| Article | Year |
|---|---|
Chitosan delivery systems for the treatment of oral mucositis: in vitro and in vivo studies.
Topics: Adult; Animals; Antifungal Agents; Biological Availability; Body Weight; Chitosan; Cricetinae; Cross-Over Studies; Drug Delivery Systems; Drug Therapy, Combination; Fluorouracil; Gels; Histocytochemistry; Humans; Lactic Acid; Male; Mesocricetus; Mouth Mucosa; Nystatin; Polyphosphates; Saliva; Stomatitis; Survival Rate; Treatment Outcome; Water | 2004 |
184 other study(ies) available for fluorouracil and chitosan
| Article | Year |
|---|---|
Prevention by chitosan of myelotoxicity, gastrointestinal toxicity and immunocompetent organic toxicity induced by 5-fluorouracil without loss of antitumor activity in mice.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chitin; Chitosan; Digestive System; Fluorouracil; Immunocompetence; Intestine, Small; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; RNA, Neoplasm; Sarcoma 180; Spleen | 1999 |
Preparation and in-vitro evaluation of poly[N-vinyl-2-pyrrolidone-polyethylene glycol diacrylate]-chitosan interpolymeric pH-responsive hydrogels for oral drug delivery.
Topics: Administration, Oral; Caffeine; Chitin; Chitosan; Drug Delivery Systems; Fluorouracil; Hydrogels; Hydrogen-Ion Concentration | 2000 |
Preparation and characterization of chitosan microspheres containing doxifluridine.
Topics: Animals; Antimetabolites, Antineoplastic; Chemistry, Pharmaceutical; Chitin; Chitosan; Drug Implants; Floxuridine; Fluorouracil; Male; Mice; Microspheres; Rats; Rats, Wistar; Tegafur | 2003 |
5-Fluorouracil in topical liposome gels for anticancer treatment--formulation and evaluation.
Topics: Administration, Topical; Chemistry, Pharmaceutical; Chitin; Chitosan; Delayed-Action Preparations; Dialysis; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Evaluation, Preclinical; Fluorouracil; Hydrogels; In Vitro Techniques; Liposomes; Pharmaceutical Vehicles; Solutions; Technology, Pharmaceutical; Time Factors; Water | 2003 |
Two-stage optimization process for formulation of chitosan microspheres.
Topics: Chemistry, Pharmaceutical; Chitin; Chitosan; Drug Carriers; Fluorouracil; Microspheres; Particle Size | 2004 |
[Preparation and properties of 5-fluorouracil-loaded chitosan microspheres for the intranasal administration].
Topics: Adhesiveness; Administration, Intranasal; Animals; Anura; Chitin; Chitosan; Fluorouracil; Microspheres; Nasal Mucosa; Solubility | 2004 |
Optimization of chitosan film as a substitute for animal and human epidermal sheets for in vitro permeation of polar and non polar drugs.
Topics: Administration, Cutaneous; Animals; Biocompatible Materials; Chitosan; Cross-Linking Reagents; Drug Delivery Systems; Epidermis; Fluorouracil; Humans; In Vitro Techniques; Indomethacin; Linear Models; Male; Models, Biological; Permeability; Polyphosphates; Rabbits; Rats; Statistics, Nonparametric | 2004 |
Sodium citrate cross-linked chitosan films: optimization as substitute for human/rat/rabbit epidermal sheets.
Topics: Animals; Chitosan; Citrates; Cross-Linking Reagents; Epidermis; Fluorouracil; Humans; Indomethacin; Rabbits; Rats; Rats, Wistar; Skin, Artificial; Sodium Citrate | 2004 |
Novel interpenetrating network chitosan-poly(ethylene oxide-g-acrylamide) hydrogel microspheres for the controlled release of capecitabine.
Topics: Acrylic Resins; Calorimetry, Differential Scanning; Capecitabine; Chitosan; Delayed-Action Preparations; Deoxycytidine; Diffusion; Fluorouracil; Hydrogel, Polyethylene Glycol Dimethacrylate; Microspheres; Polyethylene Glycols; Solubility; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction | 2006 |
Nanoparticles of 5-fluorouracil (5-FU) loaded N-succinyl-chitosan (Suc-Chi) for cancer chemotherapy: preparation, characterization--in-vitro drug release and anti-tumour activity.
Topics: Animals; Antimetabolites, Antineoplastic; Chitosan; Colloids; Delayed-Action Preparations; Diffusion; Drug Carriers; Drug Compounding; Fluorouracil; Mice; Mice, Inbred BALB C; Nanoparticles; Neoplasm Transplantation; Particle Size; Sarcoma 180; Solubility; Time Factors | 2006 |
Preparation and characterization of N-(2-carboxybenzyl)chitosan as a potential pH-sensitive hydrogel for drug delivery.
Topics: Antimetabolites, Antineoplastic; Chitosan; Cross-Linking Reagents; Drug Carriers; Drug Delivery Systems; Fluorouracil; Hydrogel, Polyethylene Glycol Dimethacrylate; Hydrogen-Ion Concentration | 2007 |
Preparation and preliminary characterization of concentric multi-walled chitosan microspheres.
Topics: Albumins; Calorimetry, Differential Scanning; Chitosan; Cross-Linking Reagents; Cytochromes c; Fluorouracil; Hydrogen-Ion Concentration; Kinetics; Microscopy, Electron, Scanning; Microspheres; Particle Size; Polyphosphates; Sodium Hydroxide; Solutions; Spectrophotometry, Infrared; Tensile Strength | 2007 |
Novel hydrogel microspheres of chitosan and pluronic F-127 for controlled release of 5-fluorouracil.
Topics: Chitosan; Fluorouracil; Hydrogels; Microscopy, Electron, Scanning; Microspheres; Poloxamer; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction | 2007 |
Nanoparticles based on the complex of chitosan and polyaspartic acid sodium salt: preparation, characterization and the use for 5-fluorouracil delivery.
Topics: Animals; Antimetabolites, Antineoplastic; Area Under Curve; Chemical Phenomena; Chemistry, Physical; Chitosan; Cross-Linking Reagents; Drug Compounding; Excipients; Fluorouracil; Half-Life; Hydrogen-Ion Concentration; Mice; Nanoparticles; Particle Size; Peptides; Temperature | 2007 |
[Preparation and release profile of colon-targeting drug delivered as novel one-step dry-coated tablets (OSDrC)].
Topics: Chitosan; Colon; Drug Delivery Systems; Fluorouracil; Gastric Emptying; Hydrogen-Ion Concentration; In Vitro Techniques; Polymethacrylic Acids; Solubility; Tablets, Enteric-Coated; Technology, Pharmaceutical; Time Factors | 2007 |
Sustained release of antineoplastic drugs from chitosan-reinforced alginate microparticle drug delivery systems.
Topics: Alginates; Antimetabolites, Antineoplastic; Antineoplastic Agents; Chemical Phenomena; Chemistry, Physical; Chitosan; Delayed-Action Preparations; Drug Compounding; Drug Delivery Systems; Excipients; Fluorouracil; Microscopy, Electron, Scanning; Nanoparticles; Particle Size; Polysaccharides; Tegafur | 2008 |
Preparation of chitosan-polyaspartic acid-5-fluorouracil nanoparticles and its anti-carcinoma effect on tumor growth in nude mice.
Topics: Animals; Antimetabolites, Antineoplastic; bcl-2-Associated X Protein; Cell Line, Tumor; Chitosan; Drug Delivery Systems; Fluorouracil; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Peptides; Proto-Oncogene Proteins c-bcl-2; Stomach Neoplasms; Treatment Outcome; Xenograft Model Antitumor Assays | 2008 |
Study on colon-specific 5-Fu pH-enzyme Di-dependent chitosan microspheres.
Topics: Animals; Chitosan; Colon; Drug Delivery Systems; Female; Fluorouracil; Hydrogen-Ion Concentration; Male; Microspheres; Particle Size; Rats; Rats, Wistar; Solubility | 2008 |
In vitro and cell uptake studies for targeting of ligand anchored nanoparticles for colon tumors.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Cell Survival; Chitosan; Colon; Colonic Neoplasms; Drug Compounding; Drug Delivery Systems; Electrochemistry; Excipients; Fluorouracil; HT29 Cells; Humans; Hyaluronic Acid; Ligands; Microscopy, Electron, Scanning; Nanoparticles; Particle Size; Photometry; Solubility; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction | 2008 |
Chitosan-coated magnetic nanoparticles as carriers of 5-fluorouracil: preparation, characterization and cytotoxicity studies.
Topics: Apoptosis; Cell Line, Tumor; Chitosan; Drug Carriers; Fluorouracil; Humans; Magnetics; Nanoparticles | 2009 |
Photopolymerization of methacrylated chitosan/PNIPAAm hybrid dual-sensitive hydrogels as carrier for drug delivery.
Topics: Acridine Orange; Acrylamides; Acrylic Resins; Calorimetry, Differential Scanning; Chitosan; Drug Carriers; Drug Delivery Systems; Fluorouracil; Hydrogels; Hydrogen-Ion Concentration; Kinetics; Light; Microscopy, Electron, Scanning; Phase Transition; Polymers; Spectroscopy, Fourier Transform Infrared; Temperature | 2009 |
Controlled release study of 5-fluorouracil-loaded chitosan/polyethylene glycol microparticles.
Topics: Antineoplastic Agents; Chitosan; Cross-Linking Reagents; Delayed-Action Preparations; Drug Compounding; Fluorouracil; Microscopy, Electron, Scanning; Particle Size; Polyethylene Glycols; Polyphosphates; Technology, Pharmaceutical | 2009 |
Effect of oral mucosal adhesive films containing ginsenoside Rb1 on 5-fluorouracil-induced oral mucositis in hamsters.
Topics: Adhesives; Administration, Topical; Alginates; Animals; Antineoplastic Agents; Chitosan; Cricetinae; Fluorouracil; Ginsenosides; Glucuronic Acid; Hexuronic Acids; Mouth Mucosa; Peroxidase; Stomatitis | 2009 |
Wheat germ agglutinin-conjugated chitosan-Ca-alginate microparticles for local colon delivery of 5-FU: development and in vitro characterization.
Topics: Adsorption; Alginates; Animals; Antimetabolites, Antineoplastic; Buffers; Calcium; Chelating Agents; Chitosan; Colonic Neoplasms; Delayed-Action Preparations; Drug Carriers; Drug Compounding; Fluorouracil; Hemagglutination; Humans; Hydrogels; Hydrogen-Ion Concentration; Kinetics; Microspheres; Mucins; Particle Size; Solubility; Surface Properties; Swine; Wheat Germ Agglutinins | 2009 |
New targeted-colon delivery system: in vitro and in vivo evaluation using X-ray imaging.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Chemistry, Pharmaceutical; Chitosan; Colon; Colonic Neoplasms; Dogs; Drug Delivery Systems; Excipients; Fluorouracil; Gastrointestinal Tract; Male; Radiography; Rats; Solubility; Tablets | 2010 |
Sustained release of 5-FU from Poloxamer gels interpenetrated by crosslinking chitosan network.
Topics: Antimetabolites, Antineoplastic; Chemistry, Pharmaceutical; Chitosan; Cross-Linking Reagents; Delayed-Action Preparations; Diffusion; Drug Carriers; Drug Compounding; Fluorouracil; Gels; Glutaral; Kinetics; Models, Chemical; Molecular Conformation; Poloxamer; Solubility; Temperature; Viscosity | 2009 |
In vivo biodistribution for tumor targeting of 5-fluorouracil (5-FU) loaded N-succinyl-chitosan (Suc-Chi) nanoparticles.
Topics: Animals; Antimetabolites, Antineoplastic; Biological Availability; Chitosan; Drug Carriers; Fluorouracil; Injections, Intravenous; Male; Mice; Mice, Inbred BALB C; Nanoparticles; Neoplasm Transplantation; Particle Size; Rats; Rats, Wistar; Sarcoma 180; Tissue Distribution | 2010 |
Preparation and characterization of 5-Fluorouracil loaded chitosan microspheres by a two-step solidification method.
Topics: Antimetabolites, Antineoplastic; Chitosan; Cross-Linking Reagents; Delayed-Action Preparations; Fluorouracil; Glutaral; Hydrogen-Ion Concentration; Microspheres; Polyphosphates; Spectroscopy, Fourier Transform Infrared; Technology, Pharmaceutical | 2010 |
Poly(ethylene glycol)-carboxymethyl chitosan-based pH-responsive hydrogels: photo-induced synthesis, characterization, swelling, and in vitro evaluation as potential drug carriers.
Topics: Calorimetry, Differential Scanning; Chitosan; Drug Carriers; Fluorouracil; Hydrogels; Hydrogen-Ion Concentration; Photochemical Processes; Polyethylene Glycols; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction | 2010 |
Cross-linked chitosan films: effect of cross-linking density on swelling parameters.
Topics: Calorimetry, Differential Scanning; Chitosan; Chromatography, High Pressure Liquid; Citrates; Cross-Linking Reagents; Diffusion; Fluorouracil; Indicators and Reagents; Indomethacin; Permeability; Polyphosphates; Sodium Citrate; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Water | 2010 |
Ophthalmic drug-loaded N,O-carboxymethyl chitosan hydrogels: synthesis, in vitro and in vivo evaluation.
Topics: Administration, Topical; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bevacizumab; Chitosan; Cicatrix; Conjunctiva; Cross-Linking Reagents; Delayed-Action Preparations; Drug Carriers; Female; Filtering Surgery; Fluorouracil; Glaucoma; Hydrogels; In Vitro Techniques; Intraocular Pressure; Iridoid Glycosides; Iridoids; Male; Microscopy, Electron, Scanning; Rabbits; Spectroscopy, Fourier Transform Infrared; Wound Healing | 2010 |
Layer-by-layer assembly of poly(L-glutamic acid)/chitosan microcapsules for high loading and sustained release of 5-fluorouracil.
Topics: Animals; Antimetabolites, Antineoplastic; Capsules; Cell Survival; Chitosan; Delayed-Action Preparations; Drug Carriers; Drug Compounding; Drug Delivery Systems; Excipients; Fibroblasts; Fluorouracil; Glutamic Acid; Mice; Pharmacokinetics; Solubility | 2011 |
Chitosan nanoparticles of 5-fluorouracil for ophthalmic delivery: characterization, in-vitro and in-vivo study.
Topics: Animals; Chitosan; Drug Delivery Systems; Eye; Female; Fluorouracil; Male; Nanoparticles; Particle Size; Rabbits; X-Ray Diffraction | 2011 |
Chitosan coated PLA nanoparticles for ophthalmic delivery: characterization, in-vitro and in-vivo study in rabbit eye.
Topics: Animals; Antimetabolites; Chitosan; Cornea; Drug Delivery Systems; Drug Stability; Fluorouracil; Goats; Microscopy, Electron, Scanning; Nanoparticles; Particle Size; Polylysine; Rabbits | 2010 |
Characterization of chitosan-carboxymethyl dextran nanoparticles as a drug carrier and as a stimulator of mouse splenocytes.
Topics: Animals; Anti-Bacterial Agents; Antimetabolites, Antineoplastic; Cefmetazole; Cell Line, Tumor; Cell Proliferation; Chitosan; Coloring Agents; Cytokines; Dextrans; Drug Carriers; Drug Liberation; Fluorouracil; Indocyanine Green; Lymphocytes; Male; Materials Testing; Mice, Inbred BALB C; Nanoparticles; Particle Size; Spleen | 2012 |
Layered inorganic nanocomposites: a promising carrier for 5-fluorouracil (5-FU).
Topics: Animals; Antimetabolites, Antineoplastic; Bentonite; Cell Line, Tumor; Cell Survival; Cells, Cultured; Chitosan; Comet Assay; Delayed-Action Preparations; DNA Damage; Drug Carriers; Fluorouracil; Humans; Liver; Lymphocytes; Male; Nanocomposites; Rats; Rats, Wistar; Static Electricity; Tissue Distribution; X-Ray Diffraction | 2012 |
Nanoporous multilayer poly(L-glutamic acid)/chitosan microcapsules for drug delivery.
Topics: Algorithms; Antimetabolites, Antineoplastic; Capsules; Cell Line, Tumor; Cell Survival; Chitosan; Delayed-Action Preparations; Drug Delivery Systems; Electrochemistry; Excipients; Fluorouracil; Humans; Microscopy, Confocal; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Particle Size; Polyglutamic Acid; Porosity; Silicon Dioxide; Sodium Chloride; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared | 2012 |
Optimization of an aqueous tablet-coating process containing carboxymethylated Cassia fistula gum.
Topics: Adhesiveness; Antimetabolites, Antineoplastic; Calorimetry, Differential Scanning; Cassia; Chemistry, Pharmaceutical; Chitosan; Fluorouracil; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kinetics; Magnesium Silicates; Plant Gums; Seeds; Solubility; Spectroscopy, Fourier Transform Infrared; Tablets, Enteric-Coated; Technology, Pharmaceutical | 2012 |
Development of hydrocortisone succinic acid/and 5-fluorouracil/chitosan microcapsules for oral and topical drug deliveries.
Topics: Administration, Oral; Administration, Topical; Animals; Capsules; Chitosan; Drug Delivery Systems; Fluorouracil; Hydrocortisone; Keratinocytes; Mice; Skin; Staphylococcus aureus; Succinic Acid | 2012 |
Fabrication and evaluation of electrospun collagen/poly(N-isopropyl acrylamide)/chitosan mat as blood-contacting biomaterials for drug delivery.
Topics: Acrylamides; Acrylic Resins; Animals; Antineoplastic Agents; Biocompatible Materials; Blood Coagulation; Cell Line; Cell Survival; Chitosan; Collagen; Drug Delivery Systems; Fluorouracil; HeLa Cells; Humans; In Vitro Techniques; Materials Testing; Mice; Microscopy, Electron, Scanning; Nanofibers; Polymers; Spectroscopy, Fourier Transform Infrared; Textiles | 2012 |
5-flourouracil loaded N,O-carboxymethyl chitosan nanoparticles as an anticancer nanomedicine for breast cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Blood Coagulation Tests; Breast Neoplasms; Caspase 3; Cell Line, Tumor; Cell Survival; Chitosan; Drug Carriers; Female; Flow Cytometry; Fluorouracil; Hemolysis; Humans; Mice; Nanoparticles; Particle Size | 2012 |
Synthesis of galactosylated chitosan/5-fluorouracil nanoparticles and its characteristics, in vitro and in vivo release studies.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Chitosan; Delayed-Action Preparations; Female; Fluorouracil; G1 Phase Cell Cycle Checkpoints; Humans; Liver Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Nanoparticles; Resting Phase, Cell Cycle | 2012 |
Chitosan coated sodium alginate-chitosan nanoparticles loaded with 5-FU for ocular delivery: in vitro characterization and in vivo study in rabbit eye.
Topics: Alginates; Animals; Aqueous Humor; Biological Availability; Chemistry, Pharmaceutical; Chitosan; Drug Delivery Systems; Drug Stability; Fluorouracil; Glucuronic Acid; Hexuronic Acids; Nanoparticles; Ophthalmic Solutions; Particle Size; Rabbits; Swine; Technology, Pharmaceutical | 2012 |
Preliminary pharmacology of galactosylated chitosan/5-fluorouracil nanoparticles and its inhibition of hepatocellular carcinoma in mice.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chitosan; Drug Delivery Systems; Fluorouracil; Liver Neoplasms; Mice; Mice, Inbred BALB C; Nanoparticles | 2012 |
Synthesis of thermo-sensitive CS-g-PNIPAM/CMC complex nanoparticles for controlled release of 5-FU.
Topics: Acrylic Resins; Carboxymethylcellulose Sodium; Chemistry Techniques, Synthetic; Chitosan; Delayed-Action Preparations; Drug Carriers; Fluorouracil; Hydrogen-Ion Concentration; Nanoparticles; Particle Size; Temperature | 2012 |
Galactosylated chitosan/5-fluorouracil nanoparticles inhibit mouse hepatic cancer growth and its side effects.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Apoptosis Regulatory Proteins; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chemistry, Pharmaceutical; Chitosan; Cytotoxicity, Immunologic; Delayed-Action Preparations; Drug Carriers; Female; Fluorouracil; Killer Cells, Natural; Liver Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Nanoparticles; T-Lymphocytes, Cytotoxic; Time Factors; Tumor Burden | 2012 |
Thermo- and pH-sensitive ionic-crosslinked hollow spheres from chitosan-based graft copolymer for 5-fluorouracil release.
Topics: Chitosan; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Fluorouracil; Hydrogen-Ion Concentration; Ions; Micelles; Nanoparticles; Particle Size; Polymers; Spectroscopy, Fourier Transform Infrared; Temperature | 2013 |
Sustained release of 5-fluorouracil from chitosan nanoparticles surface modified intra ocular lens to prevent posterior capsule opacification: an in vitro and in vivo study.
Topics: Animals; Capsule Opacification; Cells, Cultured; Chitosan; Delayed-Action Preparations; Epithelial Cells; Fluorouracil; Humans; Lenses, Intraocular; Nanoparticles; Rabbits; Surface Properties | 2013 |
Chitosan-modified PLGA nanoparticles with versatile surface for improved drug delivery.
Topics: Antimetabolites, Antineoplastic; Chemistry, Pharmaceutical; Chitosan; Delayed-Action Preparations; Drug Carriers; Fluorouracil; Hydrogen-Ion Concentration; Kinetics; Lactic Acid; Nanoparticles; Nanotechnology; Photoelectron Spectroscopy; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Solubility; Spectroscopy, Fourier Transform Infrared; Surface Properties; Technology, Pharmaceutical | 2013 |
Study of glycol chitosan-carboxymethyl β-cyclodextrins as anticancer drugs carrier.
Topics: Antineoplastic Agents; beta-Cyclodextrins; Chitosan; Doxorubicin; Drug Carriers; Fluorouracil; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Surface Plasmon Resonance; Vinblastine | 2013 |
Wheat germ agglutinin-functionalised crosslinked polyelectrolyte microparticles for local colon delivery of 5-FU: in vitro efficacy and in vivo gastrointestinal distribution.
Topics: Alginates; Animals; Antimetabolites, Antineoplastic; Caco-2 Cells; Chitosan; Colon; Colonic Neoplasms; Drug Carriers; Fluorouracil; Glucuronic Acid; Hexuronic Acids; Humans; Male; Rats; Rats, Wistar; Triticum; Wheat Germ Agglutinins | 2013 |
Semi-IPN chitosan/polyvinylpyrrolidone microspheres and films: sustained release and property optimisation.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Breast Neoplasms; Cell Line; Chitosan; Delayed-Action Preparations; Female; Fluorouracil; Humans; Microspheres; Povidone | 2013 |
Hyaluronidase enzyme core-5-fluorouracil-loaded chitosan-PEG-gelatin polymer nanocomposites as targeted and controlled drug delivery vehicles.
Topics: Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Survival; Chitosan; Delayed-Action Preparations; Drug Delivery Systems; Fluorouracil; Gelatin; Humans; Hyaluronoglucosaminidase; Nanocomposites; Polyethylene Glycols | 2013 |
Pectin-coated chitosan microgels crosslinked on superhydrophobic surfaces for 5-fluorouracil encapsulation.
Topics: Administration, Oral; Capsules; Chitosan; Drug Carriers; Fluorouracil; Gels; Glutaral; HeLa Cells; Humans; Hydrophobic and Hydrophilic Interactions; Pectins; Surface Properties; Water | 2013 |
pH-sensitive polyelectrolyte complex micelles assembled from CS-g-PNIPAM and ALG-g-P(NIPAM-co-NVP) for drug delivery.
Topics: Acrylamides; Acrylic Resins; Alginates; Chitosan; Drug Carriers; Fluorouracil; Glucuronic Acid; HeLa Cells; Hexuronic Acids; Humans; Hydrogen-Ion Concentration; Micelles; Particle Size; Temperature | 2013 |
Synthesis of glycyrrhetinic acid-modified chitosan 5-fluorouracil nanoparticles and its inhibition of liver cancer characteristics in vitro and in vivo.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Cell Line, Tumor; Chitosan; Drug Carriers; Drug Delivery Systems; Female; Fluorouracil; Glycyrrhetinic Acid; Humans; Liver; Liver Neoplasms; Mice; Mice, Inbred BALB C; Nanoparticles; Particle Size | 2013 |
Glycyrrhetinic acid-modified chitosan nanoparticles enhanced the effect of 5-fluorouracil in murine liver cancer model via regulatory T-cells.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Proliferation; Chitosan; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Carriers; Female; Fluorouracil; Glycyrrhetinic Acid; Interferon-gamma; Interleukin-2; Killer Cells, Natural; Liver Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Nanoparticles; Particle Size; Survival Rate; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Regulatory; Time Factors | 2013 |
Optimization of size and encapsulation efficiency of 5-FU loaded chitosan nanoparticles by response surface methodology.
Topics: Antimetabolites, Antineoplastic; Chitosan; Drug Carriers; Fluorouracil; Light; Linear Models; Models, Chemical; Nanoparticles; Particle Size; Polyphosphates; Scattering, Radiation; Spectrophotometry, Ultraviolet; Viscosity | 2013 |
Preparation and evaluation of chitosan based thermoreversible gels for intraperitoneal delivery of 5-fluorouracil (5-FU).
Topics: Animals; Antimetabolites, Antineoplastic; Chitosan; Colonic Neoplasms; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Carriers; Drug Delivery Systems; Fibroblasts; Fluorouracil; Gels; Glycerol; Injections, Intraperitoneal; Lethal Dose 50; Male; Mice; Mice, Inbred BALB C; Toxicity Tests, Acute; Tumor Burden | 2013 |
Folate-polyethylene glycol conjugated carboxymethyl chitosan for tumor-targeted delivery of 5-fluorouracil.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Chitosan; Drug Carriers; Fluorouracil; Folic Acid; HeLa Cells; Hep G2 Cells; Humans; Polyethylene Glycols | 2014 |
Optimized synthesis of glycyrrhetinic acid-modified chitosan 5-fluorouracil nanoparticles and their characteristics.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Chitosan; Diffusion; Drug Synergism; Female; Fluorouracil; Glycyrrhetinic Acid; Liver Neoplasms; Materials Testing; Mice; Mice, Inbred BALB C; Nanocapsules; Particle Size; Treatment Outcome | 2014 |
New chitosan nanospheres for the delivery of 5-fluorouracil: preparation, characterization and in vitro studies.
Topics: Antimetabolites, Antineoplastic; Chitosan; Drug Delivery Systems; Fluorouracil; HT29 Cells; Humans; Nanospheres | 2014 |
Overcoming multidrug resistance in 2D and 3D culture models by controlled drug chitosan-graft poly(caprolactone)-based nanoparticles.
Topics: Antimetabolites, Antineoplastic; Cell Line, Tumor; Chitosan; Delayed-Action Preparations; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluorouracil; Humans; Nanoparticles; Neoplasms; Polyesters | 2014 |
Preparation of polysaccharide derivates chitosan-graft-poly(ɛ-caprolactone) amphiphilic copolymer micelles for 5-fluorouracil drug delivery.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chitosan; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Screening Assays, Antitumor; Fluorouracil; Humans; MCF-7 Cells; Micelles; Molecular Structure; Polyesters; Polysaccharides; Structure-Activity Relationship; Surface-Active Agents | 2014 |
Development of drug-loaded chitosan-vanillin nanoparticles and its cytotoxicity against HT-29 cells.
Topics: Antimetabolites; Antineoplastic Agents; Benzaldehydes; Chitosan; Cross-Linking Reagents; Drug Compounding; Drug Delivery Systems; Excipients; Fluorouracil; HT29 Cells; Humans; Nanoparticles; Particle Size | 2016 |
In vitro combinatorial anticancer effects of 5-fluorouracil and curcumin loaded N,O-carboxymethyl chitosan nanoparticles toward colon cancer and in vivo pharmacokinetic studies.
Topics: Animals; Antineoplastic Agents; Area Under Curve; Blood Coagulation; Cell Cycle; Cell Line; Cell Line, Tumor; Chitosan; Colonic Neoplasms; Curcumin; Drug Carriers; Drug Delivery Systems; Female; Fluorouracil; Hemolysis; HT29 Cells; Humans; Hydrogen-Ion Concentration; Membrane Potentials; Mice; Nanoparticles; Spectroscopy, Fourier Transform Infrared | 2014 |
Combinatorial anticancer effects of curcumin and 5-fluorouracil loaded thiolated chitosan nanoparticles towards colon cancer treatment.
Topics: Animals; Biological Availability; Cell Cycle; Cell Line, Tumor; Chitosan; Colonic Neoplasms; Curcumin; Delayed-Action Preparations; Fluorouracil; Humans; Membrane Potential, Mitochondrial; Mice; Nanoparticles | 2014 |
Double-effective chitosan scaffold-PLGA nanoparticle system for brain tumour therapy: in vitro study.
Topics: Antimetabolites, Antineoplastic; Brain Neoplasms; Cell Line, Tumor; Chitosan; Drug Carriers; Fluorouracil; Glioblastoma; Human Umbilical Vein Endothelial Cells; Humans; Lactic Acid; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer | 2014 |
Chitosan/agarose hydrogels: cooperative properties and microfluidic preparation.
Topics: Chitosan; Drug Carriers; Fluorouracil; Hydrogels; Microfluidic Analytical Techniques; Sepharose | 2014 |
Oxidation and pH responsive nanoparticles based on ferrocene-modified chitosan oligosaccharide for 5-fluorouracil delivery.
Topics: Antimetabolites, Antineoplastic; Chitosan; Drug Carriers; Drug Delivery Systems; Ferrous Compounds; Fluorouracil; Hydrogen-Ion Concentration; Metallocenes; Nanoparticles; Oxidation-Reduction; X-Ray Diffraction | 2014 |
Design and construction of polymerized-chitosan coated Fe3O4 magnetic nanoparticles and its application for hydrophobic drug delivery.
Topics: Antimetabolites, Antineoplastic; Chitosan; Coated Materials, Biocompatible; Drug Delivery Systems; Fluorouracil; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Magnetite Nanoparticles | 2015 |
Aptamer decorated hyaluronan/chitosan nanoparticles for targeted delivery of 5-fluorouracil to MUC1 overexpressing adenocarcinomas.
Topics: Adenocarcinoma; Animals; Aptamers, Nucleotide; Chitosan; CHO Cells; Colorectal Neoplasms; Cricetinae; Cricetulus; Fluorouracil; HT29 Cells; Humans; Hyaluronic Acid; Mucin-1; Nanoparticles | 2015 |
Inorganic nanovehicle for potential targeted drug delivery to tumor cells, tumor optical imaging.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Chitosan; Drug Carriers; Ferrosoferric Oxide; Fluorouracil; Folic Acid; HEK293 Cells; HeLa Cells; Humans; Magnetite Nanoparticles; Microscopy, Confocal; Nanostructures; Rhodamines; Zirconium | 2015 |
Self-healable hydrogel on tumor cell as drug delivery system for localized and effective therapy.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Cell Proliferation; Chitosan; Drug Carriers; Drug Delivery Systems; Drug Liberation; Fluorouracil; HeLa Cells; Humans; Hydrogel, Polyethylene Glycol Dimethacrylate; Nanoparticles; Polyvinyl Alcohol; Spectroscopy, Fourier Transform Infrared | 2015 |
Assessment of sequential combination of 5-fluorouracil-loaded-chitosan-nanoparticles and ALA-photodynamic therapy on HeLa cell line.
Topics: Aminolevulinic Acid; Antimetabolites, Antineoplastic; Apoptosis; Caspase 3; Cell Survival; Chitosan; Delayed-Action Preparations; Drug Carriers; Drug Therapy, Combination; Fluorouracil; HeLa Cells; Humans; Nanoparticles; Photochemotherapy; Photosensitizing Agents; Reactive Oxygen Species | 2015 |
Dual drug loaded chitosan nanoparticles-sugar--coated arsenal against pancreatic cancer.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Line, Tumor; Chitosan; Drug Carriers; Fluorouracil; Humans; Mice; Nanoparticles; Pancreatic Neoplasms; Quercetin | 2015 |
Optimization of chitosan nanoparticles for colon tumors using experimental design methodology.
Topics: Animals; Chitosan; Colonic Neoplasms; Fluorouracil; Humans; Models, Biological; Nanoparticles | 2016 |
Surface Molecularly Imprinted Polymer of Chitosan Grafted Poly(methyl methacrylate) for 5-Fluorouracil and Controlled Release.
Topics: Adsorption; Chitosan; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Drug Liberation; Fluorouracil; Hydrogen-Ion Concentration; Microspheres; Molecular Imprinting; Polymethyl Methacrylate; Proton Magnetic Resonance Spectroscopy; Spectroscopy, Fourier Transform Infrared; Temperature; Thermogravimetry; X-Ray Diffraction | 2016 |
Polysaccharide-based nanocomplexes for co-encapsulation and controlled release of 5-Fluorouracil and Temozolomide.
Topics: Alginates; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Chitosan; Dacarbazine; Delayed-Action Preparations; Drug Carriers; Drug Combinations; Drug Compounding; Drug Liberation; Drug Stability; Fluorouracil; Glucuronic Acid; Hexuronic Acids; Nanoparticles; Pectins; Prodrugs; Temozolomide | 2016 |
A comparative study of 5-Fluorouracil release from chitosan/silver and chitosan/silver/MWCNT nanocomposites and their cytotoxicity towards MCF-7.
Topics: Antineoplastic Agents; Cell Survival; Chitosan; Drug Carriers; Drug Liberation; Fluorouracil; Humans; Inhibitory Concentration 50; MCF-7 Cells; Nanocomposites; Nanotubes, Carbon; Silver; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman | 2016 |
New hybrid magnetic nanoparticles based on chitosan-maltose derivative for antitumor drug delivery.
Topics: Animals; Antineoplastic Agents; Cell Death; Cell Survival; Chitosan; Drug Delivery Systems; Fluorouracil; Hemolysis; Humans; Kinetics; Magnetite Nanoparticles; Maltose; Microscopy, Atomic Force; Proton Magnetic Resonance Spectroscopy; Rabbits; Spectroscopy, Fourier Transform Infrared; Suspensions; Temperature; Thermogravimetry | 2016 |
Use of 5-Fluorouracil Loaded Micelles and Cisplatin in Thermosensitive Chitosan Hydrogel as an Efficient Therapy against Colorectal Peritoneal Carcinomatosis.
Topics: Animals; Antineoplastic Agents; Cell Death; Cell Line, Tumor; Cell Proliferation; Chemistry, Pharmaceutical; Chitosan; Cisplatin; Colorectal Neoplasms; Disease Models, Animal; Drug Liberation; Female; Fluorouracil; Hydrogel, Polyethylene Glycol Dimethacrylate; Immunohistochemistry; Injections; Ki-67 Antigen; Liver Neoplasms; Lung Neoplasms; Mice, Inbred BALB C; Micelles; Peritoneal Neoplasms; Rheology; Temperature | 2017 |
Cationic cyclodextrin/alginate chitosan nanoflowers as 5-fluorouracil drug delivery system.
Topics: Alginates; Animals; beta-Cyclodextrins; Calorimetry, Differential Scanning; Cations; Cell Death; Chitosan; Drug Delivery Systems; Drug Liberation; Fibroblasts; Fluorouracil; Glucuronic Acid; Hexuronic Acids; Mice; Nanoparticles; Particle Size; Proton Magnetic Resonance Spectroscopy; Spectroscopy, Fourier Transform Infrared; Static Electricity | 2017 |
Chitosan stabilized Ag-Au nanoalloy for colorimetric sensing and 5-Fluorouracil delivery.
Topics: Alloys; Chitosan; Colorimetry; Drug Carriers; Drug Liberation; Fluorouracil; Gold; Humans; MCF-7 Cells; Mercury; Nanocomposites; Silver | 2017 |
Fabrication of functional hollow microspheres constructed from MOF shells: Promising drug delivery systems with high loading capacity and targeted transport.
Topics: Biological Transport; Cell Line, Tumor; Cell Survival; Chitosan; Drug Delivery Systems; Drug Liberation; Fluoresceins; Fluorouracil; Folic Acid; Humans; Metal-Organic Frameworks; Microspheres; Nanoparticles; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction | 2016 |
Preparation and characterization of polymeric nanoparticles surface modified with chitosan for target treatment of colorectal cancer.
Topics: Chitosan; Colorectal Neoplasms; Drug Liberation; Fluorouracil; HT29 Cells; Humans; Kinetics; Nanoparticles; Particle Size; Polyesters; Polyglycolic Acid; Surface Properties | 2017 |
Chitosan nanoparticles for combined drug delivery and magnetic hyperthermia: From preparation to in vitro studies.
Topics: Cell Line, Tumor; Chitosan; Drug Delivery Systems; Fluorouracil; Humans; In Vitro Techniques; Magnetics; Nanoparticles | 2017 |
Microwave as skin permeation enhancer for transdermal drug delivery of chitosan-5-fluorouracil nanoparticles.
Topics: Administration, Cutaneous; Animals; Chitosan; Drug Delivery Systems; Fluorouracil; Male; Microwaves; Nanoparticles; Rats, Sprague-Dawley; Skin; Skin Absorption | 2017 |
Hyaluronic acid-coated chitosan nanoparticles induce ROS-mediated tumor cell apoptosis and enhance antitumor efficiency by targeted drug delivery via CD44.
Topics: A549 Cells; Antineoplastic Agents; Apoptosis; Chitosan; Drug Delivery Systems; Drug Liberation; Endoplasmic Reticulum Stress; Fluorouracil; Hep G2 Cells; Humans; Hyaluronan Receptors; Hyaluronic Acid; Mitochondria; Nanoparticles; Particle Size; Reactive Oxygen Species | 2017 |
Oral Administration of Surface-Deacetylated Chitin Nanofibers and Chitosan Inhibit 5-Fluorouracil-Induced Intestinal Mucositis in Mice.
Topics: Acetylation; Administration, Oral; Animals; Apoptosis; Caspase 3; Chitin; Chitosan; Female; Fluorouracil; Immunohistochemistry; In Situ Nick-End Labeling; Ki-67 Antigen; Mice, Inbred C57BL; Mucositis; Nanofibers; Peroxidase | 2017 |
Thermosensitive hydrogel based on chitosan and its derivatives containing medicated nanoparticles for transcorneal administration of 5-fluorouracil.
Topics: Animals; Biological Availability; Chitosan; Cornea; Dialysis; Drug Liberation; Fluorouracil; Freeze Drying; Hydrogel, Polyethylene Glycol Dimethacrylate; Image Processing, Computer-Assisted; Kinetics; Male; Nanoparticles; Ophthalmic Solutions; Rabbits; Temperature | 2017 |
In vitro and in vivo evaluation of macromolecular prodrug GC-FUA based nanoparticle for hepatocellular carcinoma chemotherapy.
Topics: A549 Cells; Absorption, Physiological; Animals; Antimetabolites, Antineoplastic; Carcinoma, Hepatocellular; Cell Survival; Chitosan; Drug Carriers; Fluorouracil; Glycosylation; Half-Life; Hemolysis; Hep G2 Cells; Hepatocytes; Humans; Liver Neoplasms; Mice; Nanoparticles; Prodrugs; Rabbits; Random Allocation; Rats, Sprague-Dawley; Tissue Distribution | 2017 |
Polysaccharide based bionanocomposite hydrogels reinforced with cellulose nanocrystals: Drug release and biocompatibility analyses.
Topics: Animals; Cellulose; Chitosan; Drug Carriers; Drug Liberation; Fluorouracil; Hydrogels; Materials Testing; Mice; Nanoparticles; NIH 3T3 Cells; Polysaccharides, Bacterial | 2017 |
Assessment of penetration potential of pH responsive double walled biodegradable nanogels coated with eucalyptus oil for the controlled delivery of 5-fluorouracil: In vitro and ex vivo studies.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Cell Line; Cell Survival; Chitosan; Delayed-Action Preparations; Drug Liberation; Eucalyptus; Fluorouracil; Gels; Hemolysis; Humans; Hydrogen-Ion Concentration; Lactic Acid; Nanostructures; Plant Oils; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Skin; Skin Absorption; Swine | 2017 |
Chitosan-based nanocomplexes for simultaneous loading, burst reduction and controlled release of doxorubicin and 5-fluorouracil.
Topics: Animals; Cell Survival; Chitosan; Delayed-Action Preparations; Doxorubicin; Drug Carriers; Fluorouracil; Mice; Nanostructures; NIH 3T3 Cells; Polyesters | 2017 |
pH responsive N-succinyl chitosan/Poly (acrylamide-co-acrylic acid) hydrogels and in vitro release of 5-fluorouracil.
Topics: Acrylamides; Chemistry, Pharmaceutical; Chitosan; Drug Delivery Systems; Drug Liberation; Fluorouracil; Hydrogels; Hydrogen-Ion Concentration; Immunosuppressive Agents; Kinetics; Microscopy, Electron, Scanning; Porosity; Spectroscopy, Fourier Transform Infrared; Thermogravimetry; X-Ray Diffraction | 2017 |
Ultrasound-assisted synthesis of pH-responsive nanovector based on PEG/chitosan coated magnetite nanoparticles for 5-FU delivery.
Topics: Cell Survival; Chemistry Techniques, Synthetic; Chitosan; Drug Carriers; Drug Liberation; Fluorouracil; Humans; Hydrogen-Ion Concentration; Magnetite Nanoparticles; MCF-7 Cells; Polyethylene Glycols; Ultrasonic Waves | 2017 |
Histological analysis of anti-cancer drug loaded, targeted Mn:ZnS quantum dots in metastatic lesions of 4T1 challenged mice.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Chitosan; Female; Fluorouracil; Manganese Compounds; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Quantum Dots; Sulfides; Zinc Compounds | 2017 |
Chitosan-Coated Cinnamon/Oregano-Loaded Solid Lipid Nanoparticles to Augment 5-Fluorouracil Cytotoxicity for Colorectal Cancer: Extract Standardization, Nanoparticle Optimization, and Cytotoxicity Evaluation.
Topics: Antineoplastic Agents; Cell Survival; Chitosan; Cinnamomum zeylanicum; Colorectal Neoplasms; Drug Carriers; Fluorouracil; HCT116 Cells; Humans; Lipids; Nanoparticles; Origanum; Plant Extracts | 2017 |
Novel polymeric composites based on carboxymethyl chitosan and poly(acrylic acid): in vitro and in vivo evaluation.
Topics: Acrylic Resins; Animals; Area Under Curve; Cell Survival; Chitosan; Chlorocebus aethiops; Fluorouracil; Half-Life; HeLa Cells; Humans; Hydrogen-Ion Concentration; Microscopy, Electron, Scanning; Polymers; Rabbits; Surface Properties; Vero Cells | 2017 |
Cytocompatible chitosan-graft-mPEG-based 5-fluorouracil-loaded polymeric nanoparticles for tumor-targeted drug delivery.
Topics: Animals; Cell Line; Cell Line, Tumor; Cell Survival; Chitosan; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Fluorouracil; Folic Acid; Humans; MCF-7 Cells; Mice; Nanoparticles; Particle Size; Polyethylene Glycols; Polymers; RAW 264.7 Cells | 2018 |
Formation and characterization of polyelectrolyte complex synthesized by chitosan and carboxylic curdlan for 5-fluorouracil delivery.
Topics: beta-Glucans; Chitosan; Drug Carriers; Fluorouracil; HeLa Cells; Humans; Nanoparticles; Neoplasms; Polyelectrolytes | 2018 |
Irinotecan and 5-fluorouracil-co-loaded, hyaluronic acid-modified layer-by-layer nanoparticles for targeted gastric carcinoma therapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Chemistry, Pharmaceutical; Chitosan; Drug Carriers; Drug Delivery Systems; Fluorouracil; Humans; Hyaluronic Acid; Irinotecan; Lactic Acid; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Stomach Neoplasms | 2017 |
Hydroxyapatite-chitosan biocomposites synthesized in the simulated body fluid and their drug loading studies.
Topics: Body Fluids; Chitosan; Drug Carriers; Drug Compounding; Drug Delivery Systems; Drug Liberation; Durapatite; Fluorouracil; Materials Testing; Microscopy, Electron, Scanning; Nanocomposites; Particle Size; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction | 2017 |
Synthesis and characterization of cystamine conjugated chitosan-SS-mPEG based 5-Fluorouracil loaded polymeric nanoparticles for redox responsive drug release.
Topics: Biological Transport; Cell Survival; Chemistry, Pharmaceutical; Chitosan; Cystamine; Drug Delivery Systems; Drug Liberation; Fluorouracil; Folic Acid; Humans; MCF-7 Cells; Nanoparticles; Oxidation-Reduction; Particle Size; Polyethylene Glycols; Surface Properties | 2018 |
Co-delivery of hypoxia inducible factor-1α small interfering RNA and 5-fluorouracil to overcome drug resistance in gastric cancer SGC-7901 cells.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Survival; Chitosan; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice; Nanoparticles; RNA, Small Interfering; Stomach Neoplasms | 2017 |
Preparation and Bioactivity Assessment of Chitosan-1-Acetic Acid-5-Flurouracil Conjugates as Cancer Prodrugs.
Topics: Acetic Acid; Animals; Antineoplastic Agents; Cell Line, Tumor; Chitosan; Colorectal Neoplasms; Fluorouracil; Humans; Prodrugs; Rabbits | 2017 |
Drug delivery systems based on biocompatible imino-chitosan hydrogels for local anticancer therapy.
Topics: Animals; Antineoplastic Agents; Biocompatible Materials; Chitosan; Delayed-Action Preparations; Drug Delivery Systems; Fluorouracil; Hydrogels; Imines; Mice; Microscopy, Electron, Scanning; Porosity; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction | 2018 |
Therapeutic efficacy of rebamipide-loaded PLGA nanoparticles coated with chitosan in a mouse model for oral mucositis induced by cancer chemotherapy.
Topics: Alanine; Animals; Anti-Ulcer Agents; Chitosan; Coated Materials, Biocompatible; Drug Liberation; Fluorouracil; Lactic Acid; Male; Mice, Inbred ICR; Microscopy, Electron, Scanning; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Quinolones; Stomatitis; Treatment Outcome | 2018 |
Chitosan-Carboxymethyl-5-Fluorouracil-Folate Conjugate Particles: Microwave Modulated Uptake by Skin and Melanoma Cells.
Topics: Administration, Cutaneous; Cell Line, Tumor; Chitosan; Drug Delivery Systems; Fluorouracil; Folic Acid; Humans; Melanoma; Membrane Microdomains; Microwaves; Nanoparticles; Skin; Skin Absorption; Skin Neoplasms | 2018 |
Preparation and Properties of 5-Fluorouracil-Loaded Chitosan Microspheres for the Intranasal Administration.
Topics: Administration, Intranasal; Animals; Central Nervous System Diseases; Chitosan; Drug Carriers; Drug Compounding; Drug Evaluation, Preclinical; Drug Liberation; Emulsions; Fluorouracil; Microspheres; Nasal Mucosa; Prospective Studies; Ranidae; Reproducibility of Results | 2018 |
Synthesis of Biotin-Modified Galactosylated Chitosan Nanoparticles and Their Characteristics in Vitro and in Vivo.
Topics: Animals; Antimetabolites, Antineoplastic; Biotin; Cell Line; Cell Movement; Cell Proliferation; Chitosan; Drug Carriers; Fluorouracil; Galactose; Humans; Liver; Liver Neoplasms; Magnetic Resonance Spectroscopy; Mice; Nanoparticles; Optical Imaging; Particle Size; Spectroscopy, Fourier Transform Infrared | 2018 |
Development of a photoresponsive chitosan conjugated prodrug nano-carrier for controlled delivery of antitumor drug 5-fluorouracil.
Topics: Antineoplastic Agents; Chitosan; Drug Carriers; Drug Liberation; Fluorouracil; Light; Molecular Weight; Nanoparticles; Prodrugs; Solubility | 2019 |
pH-sensitive ZnO/carboxymethyl cellulose/chitosan bio-nanocomposite beads for colon-specific release of 5-fluorouracil.
Topics: Carboxymethylcellulose Sodium; Chitosan; Colon; Drug Carriers; Drug Liberation; Fluorouracil; Microspheres; Nanocomposites; Organ Specificity; Zinc Oxide | 2019 |
pH/Thermo-Dual Responsive Tunable In Situ Cross-Linkable Depot Injectable Hydrogels Based on Poly(N-Isopropylacrylamide)/Carboxymethyl Chitosan with Potential of Controlled Localized and Systemic Drug Delivery.
Topics: Acrylic Resins; Calorimetry, Differential Scanning; Chitosan; Cross-Linking Reagents; Delayed-Action Preparations; Drug Delivery Systems; Fluorouracil; HeLa Cells; Humans; Hydrogels; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; MCF-7 Cells; Microscopy, Electron, Scanning; Phase Transition; Porosity; Spectroscopy, Fourier Transform Infrared; Temperature; Thermogravimetry | 2019 |
Delivery of Liver-Specific miRNA-122 Using a Targeted Macromolecular Prodrug toward Synergistic Therapy for Hepatocellular Carcinoma.
Topics: ADAM17 Protein; Animals; Apoptosis; Biocompatible Materials; Carcinoma, Hepatocellular; Cell Line; Chitosan; Down-Regulation; Drug Carriers; Drug Synergism; Fluorouracil; Hemolysis; Hep G2 Cells; Humans; Liver Neoplasms; Mice; Mice, Inbred BALB C; MicroRNAs; Nanoparticles; Prodrugs | 2019 |
Multiple comparisons of three different sources of biomaterials in the application of tumor tissue engineering in vitro and in vivo.
Topics: Animals; Biocompatible Materials; Cell Line, Tumor; Cell Proliferation; Chitosan; Drug Resistance, Neoplasm; Extracellular Matrix; Fluorouracil; Gelatin; Humans; Lung; Mice; Polyesters; Swine; Tissue Engineering; Tissue Scaffolds; Xenograft Model Antitumor Assays | 2019 |
Formulation, Characterization and
Topics: Animals; Calorimetry, Differential Scanning; Cell Death; Cell Line, Tumor; Cell Survival; Chitosan; Diffusion; Drug Compounding; Drug Liberation; Fluorouracil; Goats; Humans; Nanofibers; Permeability; Polymers; Polyvinyl Alcohol; Reproducibility of Results; Skin Neoplasms; Spectroscopy, Fourier Transform Infrared; Temperature; Tensile Strength | 2019 |
Magnetic bio-metal-organic framework nanocomposites decorated with folic acid conjugated chitosan as a promising biocompatible targeted theranostic system for cancer treatment.
Topics: Animals; Biocompatible Materials; Cell Death; Cell Line, Tumor; Cell Survival; Chitosan; Curcumin; Drug Liberation; Erythrocytes; Ferric Compounds; Fluorouracil; Folic Acid; Hemolysis; Humans; Magnetic Resonance Imaging; Magnetics; Metal-Organic Frameworks; Mice; Mice, Inbred BALB C; Nanocomposites; Neoplasms; NIH 3T3 Cells; Phantoms, Imaging; Protein Corona; Theranostic Nanomedicine; X-Ray Diffraction | 2019 |
Dual-layered pH-sensitive alginate/chitosan/kappa-carrageenan microbeads for colon-targeted release of 5-fluorouracil.
Topics: Alginates; Carrageenan; Chitosan; Colon; Drug Carriers; Drug Liberation; Fluorouracil; Hydrogen-Ion Concentration; Microspheres; Models, Molecular; Molecular Conformation | 2019 |
Simultaneous controlled release of 5-FU, DOX and PTX from chitosan/PLA/5-FU/g-C3N4-DOX/g-C3N4-PTX triaxial nanofibers for breast cancer treatment in vitro.
Topics: Breast Neoplasms; Cell Adhesion; Cell Survival; Chitosan; Delayed-Action Preparations; Doxorubicin; Drug Liberation; Female; Fluorouracil; Graphite; Humans; Kinetics; MCF-7 Cells; Nanofibers; Nitriles; Paclitaxel; Polyesters; X-Ray Diffraction | 2019 |
Magnetic and self-healing chitosan-alginate hydrogel encapsulated gelatin microspheres via covalent cross-linking for drug delivery.
Topics: Alginates; Chitosan; Drug Delivery Systems; Fluorouracil; Gelatin; Hydrogels; Microspheres | 2019 |
Redox-responsive blend hydrogel films based on carboxymethyl cellulose/chitosan microspheres as dual delivery carrier.
Topics: Apoptosis; Carboxymethylcellulose Sodium; Cell Line, Tumor; Cell Survival; Chemical Phenomena; Chitosan; Drug Carriers; Drug Delivery Systems; Drug Liberation; Fluorouracil; Humans; Hydrogen-Ion Concentration; Mechanical Phenomena; Methylgalactosides; Microspheres; Oxidation-Reduction; Rheology; Spectroscopy, Fourier Transform Infrared | 2019 |
Study of 5-Fluorouracil Loaded Chitosan Nanoparticles for Treatment of Skin Cancer.
Topics: Analysis of Variance; Calorimetry, Differential Scanning; Cell Death; Cell Line, Tumor; Chitosan; Drug Compounding; Drug Liberation; Fluorouracil; Humans; Nanoparticles; Particle Size; Polyphosphates; Regression Analysis; Skin Neoplasms; Spectroscopy, Fourier Transform Infrared; Static Electricity; Thermogravimetry; Time Factors | 2020 |
A novel core-shell nanofiber drug delivery system intended for the synergistic treatment of melanoma.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Proliferation; Chitosan; Drug Delivery Systems; Drug Liberation; Drug Synergism; Fluorouracil; Melanoma, Experimental; Mice; Nanofibers; Polyesters; Povidone; Skin Neoplasms | 2019 |
High molecular weight cross linked chitosan nanoparticles for controlled release of 5-Fluorouracil; Enhances its bioavailability.
Topics: Biological Availability; Calorimetry, Differential Scanning; Chitosan; Cross-Linking Reagents; Delayed-Action Preparations; Drug Stability; Fluorouracil; Glutaral; Hydrogen Bonding; Microscopy, Electron, Scanning; Molecular Weight; Nanoparticles; Particle Size; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction | 2019 |
An oral drug delivery system with programmed drug release and imaging properties for orthotopic colon cancer therapy.
Topics: Acrylic Resins; Administration, Oral; Animals; Chitosan; Colonic Neoplasms; Contrast Media; Delayed-Action Preparations; Durapatite; Fluorouracil; Gadolinium; Gefitinib; HT29 Cells; Humans; Magnetic Resonance Imaging; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles | 2019 |
Facile synthesis of bentonite/biopolymer composites as low-cost carriers for 5-fluorouracil drug; equilibrium studies and pharmacokinetic behavior.
Topics: Bentonite; Chemistry Techniques, Synthetic; Chitosan; Costs and Cost Analysis; Drug Carriers; Drug Liberation; Fluorouracil; Hydrogen-Ion Concentration; Surface-Active Agents; Tissue Distribution | 2019 |
Targeted Nanoparticles for Co-delivery of 5-FU and Nitroxoline, a Cathepsin B Inhibitor, in HepG2 Cells of Hepatocellular Carcinoma.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cathepsin B; Chitosan; Chondroitin; Drug Liberation; Drug Therapy, Combination; Fluorouracil; Hep G2 Cells; Humans; Hyaluronic Acid; Liver Neoplasms; Mice; Molecular Targeted Therapy; Nanocapsules; NIH 3T3 Cells; Nitroquinolines; Protease Inhibitors | 2020 |
Synthesis of magnetic gold coated poly (ε-caprolactonediol) based polyurethane/poly(N-isopropylacrylamide)-grafted-chitosan core-shell nanofibers for controlled release of paclitaxel and 5-FU.
Topics: Acrylic Resins; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Chitosan; Coated Materials, Biocompatible; Delayed-Action Preparations; Drug Carriers; Female; Fluorouracil; Gold; Magnetic Iron Oxide Nanoparticles; Mammary Neoplasms, Animal; Mice; Mice, Inbred BALB C; Nanofibers; Paclitaxel; Polyesters; Polyurethanes | 2020 |
Preparation and characterization of carboxymethyl cellulose containing quaternized chitosan for potential drug carrier.
Topics: Anti-Bacterial Agents; Apoptosis; Bandages; Carboxymethylcellulose Sodium; Chitosan; Drug Carriers; Drug Liberation; Fluorouracil; Hemolysis; Hep G2 Cells; Humans; Hydrogels; Mechanical Phenomena; Rheology; Wound Healing | 2020 |
Biocompatible chitosan-carbon nanocage hybrids for sustained drug release and highly efficient laser and microwave co-irradiation induced cancer therapy.
Topics: Animals; Biocompatible Materials; Carbon; Cell Cycle; Cell Death; Cell Line, Tumor; Cell Survival; Chitosan; Delayed-Action Preparations; Drug Liberation; Fluorouracil; Lasers; Mice, Inbred BALB C; Mice, Nude; Microwaves; Nanoparticles; Neoplasms; Photothermal Therapy; Temperature | 2020 |
New reductant-free synthesis of gold nanoparticles-doped chitosan-based semi-IPN nanogel: A robust nanoreactor for exclusively sensitive 5-fluorouracil sensor.
Topics: Biosensing Techniques; Chitosan; Fluorouracil; Gold; Humans; Limit of Detection; Metal Nanoparticles; Nanogels; Polymers | 2020 |
A competent bidrug loaded water soluble chitosan derivative for the effective inhibition of breast cancer.
Topics: Breast Neoplasms; Chitosan; Doxorubicin; Drug Carriers; Drug Liberation; Fluorouracil; Humans; Inhibitory Concentration 50; MCF-7 Cells; Solubility; Water | 2020 |
Polyelectrolyte three layer nanoparticles of chitosan/dextran sulfate/chitosan for dual drug delivery.
Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Chitosan; Dextran Sulfate; Drug Delivery Systems; Drug Liberation; Drug Screening Assays, Antitumor; Fluorouracil; Hep G2 Cells; Humans; Nanoparticles; Paclitaxel; Particle Size; Polyelectrolytes; Surface Properties | 2020 |
5-Fluorouracil monodispersed chitosan microspheres: Microfluidic chip fabrication with crosslinking, characterization, drug release and anticancer activity.
Topics: Antimetabolites, Antineoplastic; Cell Survival; Chitosan; Cross-Linking Reagents; Drug Carriers; Drug Liberation; Fluorouracil; Glutaral; Hep G2 Cells; Humans; Hydrogen-Ion Concentration; Kinetics; Lab-On-A-Chip Devices; Microfluidics; Microspheres; Polyphosphates | 2020 |
Formulation, characterization and in vitro release study of 5-fluorouracil loaded chitosan nanoparticles.
Topics: Calorimetry, Differential Scanning; Chitosan; Drug Carriers; Drug Compounding; Drug Delivery Systems; Drug Liberation; Fluorouracil; Ions; Kinetics; Nanoparticles; Particle Size; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction | 2020 |
Chitosan mediated 5-Fluorouracil functionalized silica nanoparticle from rice husk for anticancer activity.
Topics: Antimetabolites, Antineoplastic; Biomarkers; Cell Line, Tumor; Cell Survival; Chitosan; Drug Carriers; Drug Compounding; Drug Delivery Systems; Fluorescent Antibody Technique; Fluorouracil; Humans; Nanoparticles; Oryza; Particle Size; Silicon Dioxide | 2020 |
Topical delivery of 5-fluorouracil-loaded carboxymethyl chitosan nanoparticles using microneedles for keloid treatment.
Topics: Chitosan; Drug Delivery Systems; Fluorouracil; Humans; Keloid; Nanoparticles | 2021 |
In Vitro Release of 5-Fluorouracil and Methotrexate from Different Thermosensitive Chitosan Hydrogel Systems.
Topics: Antimetabolites, Antineoplastic; Calorimetry, Differential Scanning; Chitosan; Drug Delivery Systems; Drug Liberation; Fluorouracil; Hydrogels; Methotrexate; Temperature | 2020 |
ROS-Responsive Chitosan Coated Magnetic Iron Oxide Nanoparticles as Potential Vehicles for Targeted Drug Delivery in Cancer Therapy.
Topics: Antineoplastic Agents; Cell Death; Cell Line, Tumor; Chitosan; Drug Carriers; Drug Delivery Systems; Drug Liberation; Ferric Compounds; Fluorouracil; Humans; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Magnetite Nanoparticles; Neoplasms; Oleic Acid; Particle Size; Reactive Oxygen Species; Spectroscopy, Fourier Transform Infrared; Temperature; X-Ray Diffraction | 2020 |
Folate-induced nanostructural changes of oligochitosan nanoparticles and their fate of cellular internalization by melanoma.
Topics: Antineoplastic Agents; Cell Line, Tumor; Chitin; Chitosan; Drug Carriers; Fluorouracil; Folic Acid; Humans; Melanoma; Melanoma, Cutaneous Malignant; Nanoparticles; Oligosaccharides; Skin Neoplasms | 2020 |
Functionalized layer-by-layer assembled film with directional 5-fluorouracil release to target colon cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Caco-2 Cells; Capsules; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chitosan; Colonic Neoplasms; Drug Compounding; Fluorouracil; Folic Acid; Humans; Male; Polyesters; Rabbits; Rats; Spheroids, Cellular; Xenograft Model Antitumor Assays | 2020 |
Facile Fabrication of Nanoparticles with Dual-Targeting Ligands for Precise Hepatocellular Carcinoma Therapy
Topics: A549 Cells; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line; Cell Line, Tumor; Chitosan; Fluorouracil; Folic Acid; Hepatocytes; Human Umbilical Vein Endothelial Cells; Humans; Ligands; Liver Neoplasms; Nanoparticles; Precision Medicine; Prodrugs; Solubility | 2020 |
Chitosan nanoparticles loaded with aspirin and 5-fluororacil enable synergistic antitumour activity through the modulation of NF-κB/COX-2 signalling pathway.
Topics: Antineoplastic Agents; Aspirin; Chitosan; Cyclooxygenase 2; Drug Synergism; Fluorouracil; Hep G2 Cells; Humans; Nanoparticles; NF-kappa B; Signal Transduction | 2020 |
Antitumoral Drug: Loaded Hybrid Nanocapsules Based on Chitosan with Potential Effects in Breast Cancer Therapy.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Survival; Chitosan; Drug Liberation; Female; Fluorouracil; Humans; Kinetics; Magnetite Nanoparticles; MCF-7 Cells; Nanocapsules; Particle Size; Spectroscopy, Fourier Transform Infrared; Static Electricity; Temperature; Thermogravimetry | 2020 |
Design of polysaccharidic nano-in-micro soft agglomerates as primary oral drug delivery vehicle for colon-specific targeting.
Topics: Administration, Oral; Alginates; Antimetabolites; Chitosan; Colon; Drug Delivery Systems; Drug Liberation; Fluorouracil; Folic Acid; Humans; Nanoparticles; Pectins; Vitamin B Complex | 2020 |
3D printed intelligent scaffold prevents recurrence and distal metastasis of breast cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Chemotherapy, Adjuvant; Chitosan; Doxycycline; Drug Carriers; Drug Compounding; Female; Fluorouracil; Gelatin; Humans; Mammary Glands, Animal; Mastectomy; Mice; Neoplasm Metastasis; Neoplasm Recurrence, Local; Polylactic Acid-Polyglycolic Acid Copolymer; Printing, Three-Dimensional; Smart Materials; Surgical Wound; Tissue Scaffolds; Wound Healing; Xenograft Model Antitumor Assays | 2020 |
Chitosan/carbon quantum dot/aptamer complex as a potential anticancer drug delivery system towards the release of 5-fluorouracil.
Topics: Antineoplastic Agents; Aptamers, Nucleotide; Breast Neoplasms; Carbon; Cell Proliferation; Cell Survival; Chitosan; Drug Delivery Systems; Drug Liberation; Female; Fluorouracil; Humans; MCF-7 Cells; Nanoparticles; Quantum Dots | 2020 |
Synthesis of chitosan nanocomposites for controlled release applications.
Topics: Chitosan; Copper; Delayed-Action Preparations; Drug Stability; Durapatite; Fluorouracil; Nanocomposites; Nanotubes, Carbon; Nitrates; Thermodynamics | 2021 |
Understanding the role of colon-specific microparticles based on retrograded starch/pectin in the delivery of chitosan nanoparticles along the gastrointestinal tract.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Chitosan; Colon; Colorectal Neoplasms; Drug Carriers; Drug Compounding; Drug Liberation; Female; Fluorouracil; Gastrointestinal Microbiome; Humans; Intestinal Absorption; Intestinal Mucosa; Mice; Models, Animal; Nanoparticles; Particle Size; Pectins; Proof of Concept Study; Starch; Tissue Distribution | 2021 |
Application of a novel thermo-sensitive injectable hydrogel in therapy in situ for drug accurate controlled release.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Survival; Chitosan; Delayed-Action Preparations; Drug Delivery Systems; Drug Liberation; Female; Fluorouracil; Hydrogels; Materials Testing; Mice; Neoadjuvant Therapy; Neoplasms; Neoplasms, Experimental; Swine; Thermodynamics | 2020 |
Chitosan/PCL nanoparticles can improve anti-neoplastic activity of 5-fluorouracil in head and neck cancer through autophagy activation.
Topics: Animals; Antimetabolites, Antineoplastic; Autophagy; Cell Line, Tumor; Cell Survival; Chitosan; Drug Liberation; Fluorouracil; Head and Neck Neoplasms; Humans; Mice; Nanoparticles; Particle Size; Polyesters | 2021 |
Gamma radiation synthesis of a novel amphiphilic terpolymer hydrogel pH-responsive based chitosan for colon cancer drug delivery.
Topics: Acrylamides; Acrylates; Alkanesulfonates; Antimetabolites, Antineoplastic; Chitosan; Colonic Neoplasms; Cross-Linking Reagents; Drug Delivery Systems; Drug Liberation; Fluorouracil; Gamma Rays; Humans; Hydrogels; Hydrogen-Ion Concentration; Kinetics; Polymers; Surface-Active Agents; Water | 2021 |
Fabrication of self-healing pectin/chitosan hybrid hydrogel via Diels-Alder reactions for drug delivery with high swelling property, pH-responsiveness, and cytocompatibility.
Topics: Animals; Cell Line; Chitosan; Citrus; Cycloaddition Reaction; Drug Carriers; Drug Liberation; Fluorouracil; Furans; Hydrogels; Hydrogen-Ion Concentration; Kinetics; Maleimides; Mechanical Phenomena; Mice; Pectins; Temperature | 2021 |
Preparation of 5-fluorouracil loaded chitosan microtube via in situ precipitation for glaucoma drainage device application: in vitro and in vivo investigation.
Topics: Chitosan; Fluorouracil; Glaucoma; Glaucoma Drainage Implants; Humans; Intraocular Pressure | 2021 |
Pharmacokinetic variables of medium molecular weight cross linked chitosan nanoparticles to enhance the bioavailability of 5-fluorouracil and reduce the acute oral toxicity.
Topics: Animals; Antineoplastic Agents; Chemistry, Pharmaceutical; Chitosan; Delayed-Action Preparations; Drug Carriers; Drug Liberation; Drug Stability; Fluorouracil; Glutaral; Molecular Weight; Mouth Diseases; Nanoparticles; Particle Size; Rabbits | 2021 |
Preparation and synergistic chemo-photothermal therapy of redox-responsive carboxymethyl cellulose/chitosan complex nanoparticles.
Topics: Animals; Antimetabolites, Antineoplastic; Carbohydrate Conformation; Carboxymethylcellulose Sodium; Cell Proliferation; Cell Survival; Chitosan; Drug Liberation; Drug Screening Assays, Antitumor; Fluorouracil; Hep G2 Cells; Humans; Liver Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Particle Size; Photothermal Therapy | 2022 |
Synthesis and characterization of a novel pH-responsive drug-releasing nanocomposite hydrogel for skin cancer therapy and wound healing.
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Biocompatible Materials; Cell Line, Tumor; Cell Survival; Chitosan; Drug Delivery Systems; Fluorouracil; Humans; Hydrogels; Hydrogen-Ion Concentration; Nanocomposites; Polyethylene Glycols; Skin Neoplasms; Wound Healing | 2021 |
A novel modified chitosan/collagen coated-gold nanoparticles for 5-fluorouracil delivery: Synthesis, characterization, in vitro drug release studies, anti-inflammatory activity and in vitro cytotoxicity assay.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Cell Proliferation; Cell Survival; Cells, Cultured; Chitosan; Collagen; Drug Delivery Systems; Drug Liberation; Drug Screening Assays, Antitumor; Fluorouracil; Gold; Humans; Lipopolysaccharides; Metal Nanoparticles; Mice; Molecular Structure; Nitric Oxide; Particle Size; RAW 264.7 Cells | 2022 |
Synthesis of highly fluorescent, amine-functionalized carbon dots from biotin-modified chitosan and silk-fibroin blend for target-specific delivery of antitumor agents.
Topics: Amines; Antimetabolites, Antineoplastic; Biotin; Carbon; Cell Proliferation; Cell Survival; Cells, Cultured; Chitosan; Drug Delivery Systems; Drug Liberation; Drug Screening Assays, Antitumor; Fibroins; Fluorescence; Fluorouracil; Humans; Molecular Structure; Optical Imaging; Particle Size; Quantum Dots; Spectrometry, Fluorescence | 2022 |
Preparation and characterization of magnetic nanohydrogel based on chitosan for 5-fluorouracil drug delivery and kinetic study.
Topics: Chitosan; Drug Carriers; Drug Delivery Systems; Drug Liberation; Fluorouracil; Magnetic Phenomena; Spectroscopy, Fourier Transform Infrared | 2022 |
Theoretical Investigation of Chitosan-Assisted Controlled Release of Digestive System Antitumor Drug Fluorouracil.
Topics: Antineoplastic Agents; Chitosan; Delayed-Action Preparations; Digestive System; Drug Carriers; Drug Delivery Systems; Drug Liberation; Fluorouracil | 2022 |
Controlled release of 5-fluorouracil to melanoma cells using a hydrogel/micelle composites based on deoxycholic acid and carboxymethyl chitosan.
Topics: Chitosan; Delayed-Action Preparations; Deoxycholic Acid; Drug Carriers; Drug Delivery Systems; Fluorouracil; Humans; Hydrogels; Melanoma; Micelles; Skin Neoplasms; Spectroscopy, Fourier Transform Infrared | 2022 |
Anticancer therapeutic potential of 5-fluorouracil and nisin co-loaded chitosan coated silver nanoparticles against murine skin cancer.
Topics: Animals; Antioxidants; Chitosan; Fluorouracil; Metal Nanoparticles; Mice; Nanoparticles; Nisin; Oxidants; Particle Size; Silver; Skin Neoplasms | 2022 |
Chitosan-Gelatin-EGCG Nanoparticle-Meditated LncRNA TMEM44-AS1 Silencing to Activate the P53 Signaling Pathway for the Synergistic Reversal of 5-FU Resistance in Gastric Cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Catechin; Cell Line, Tumor; Chitosan; Drug Resistance, Neoplasm; Fluorouracil; Gelatin; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Mice; MicroRNAs; Nanoparticles; Repressor Proteins; RNA; RNA, Antisense; RNA, Long Noncoding; Signal Transduction; Stomach Neoplasms; Tumor Suppressor Protein p53 | 2022 |
Cerium oxide decorated 5-fluorouracil loaded chitosan nanoparticles for treatment of hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cerium; Chitosan; Fibroblasts; Fluorouracil; Liver Neoplasms; Mammals; Mice; Nanoparticles; NIH 3T3 Cells; Reactive Oxygen Species | 2022 |
ROS-generating, pH-responsive and highly tunable reduced graphene oxide-embedded microbeads showing intrinsic anticancer properties and multi-drug co-delivery capacity for combination cancer therapy.
Topics: Alginates; Chitosan; Curcumin; Drug Carriers; Drug Liberation; Fluorouracil; Graphite; Humans; Hydrogen-Ion Concentration; Microspheres; Neoplasms; Reactive Oxygen Species | 2022 |
Chitosan/Gamma-Alumina/Fe
Topics: Aluminum Oxide; Chitosan; Drug Carriers; Fluorouracil; Humans; Nanoparticles; Neoplasms; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction | 2022 |
Folate decorated lipid chitosan hybrid nanoparticles of 5-fluorouracil for enhanced anticancer efficacy against colon cancer.
Topics: Cell Line, Tumor; Chitosan; Colonic Neoplasms; Drug Carriers; Drug Delivery Systems; Fluorouracil; Folic Acid; Humans; Lipids; Nanoparticles; Particle Size | 2022 |
The design of multi-responsive nanohydrogel networks of chitosan for controlled drug delivery.
Topics: Chitosan; Doxorubicin; Drug Carriers; Drug Delivery Systems; Drug Liberation; Fluorouracil; Hydrogels; Hydrogen-Ion Concentration | 2022 |
Optimized aptamer functionalization for enhanced anticancer efficiency in vivo.
Topics: Animals; Aptamers, Nucleotide; Cell Line, Tumor; Chitosan; Drug Carriers; Drug Delivery Systems; Fluorouracil; Mice; Polymers; Prodrugs | 2022 |
Chitosan modified 5-fluorouracil nanostructured lipid carriers for treatment of diabetic retinopathy in rats: A new dimension to an anticancer drug.
Topics: Animals; Antineoplastic Agents; Chitosan; Diabetes Mellitus; Diabetic Retinopathy; Drug Carriers; Drug Liberation; Fluorouracil; Lipids; Nanostructures; Particle Size; Rats | 2023 |
Fabrication, in Vitro, and in Vivo Characterization of Mucoadhesive Berberine-Loaded Blended Wafers for Treatment of Chemotherapy-Induced Oral Mucositis.
Topics: Alginates; Animals; Antineoplastic Agents; Berberine; Chitosan; Fluorouracil; Hypromellose Derivatives; Rats; Spectroscopy, Fourier Transform Infrared; Stomatitis | 2022 |
3D-printed long-acting 5-fluorouracil implant to prevent conjunctival fibrosis in glaucoma.
Topics: Chitosan; Delayed-Action Preparations; Fluorouracil; Glaucoma; Humans; Printing, Three-Dimensional | 2023 |
Synthesis of biodegradable antimicrobial pH-sensitive silver nanocomposites reliant on chitosan and carrageenan derivatives for 5-fluorouracil drug delivery toward HCT116 cancer cells.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Carrageenan; Chitosan; Fluorouracil; HCT116 Cells; Humans; Hydrogen-Ion Concentration; Metal Nanoparticles; Nanocomposites; Neoplasms; Silver | 2023 |
Chitosan coated magnetic cellulose nanowhisker as a drug delivery system for potential colorectal cancer treatment.
Topics: Cellulose; Chitosan; Colorectal Neoplasms; Drug Delivery Systems; Drug Liberation; Fluorouracil; Humans; Magnetic Phenomena; Nanocomposites; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction | 2023 |
Mesoporous Silica Nanoparticles Coated with Carboxymethyl Chitosan for 5-Fluorouracil Ocular Delivery: Characterization, In Vitro and In Vivo Studies.
Topics: Animals; Chitosan; Cornea; Drug Carriers; Drug Delivery Systems; Fluorouracil; Nanoparticles; Particle Size; Rabbits; Renal Dialysis | 2023 |
pH-responsive chitosan/acrylamide/gold/nanocomposite supported with silver nanoparticles for controlled release of anticancer drug.
Topics: Acrylamides; Anti-Bacterial Agents; Anti-Infective Agents; Antineoplastic Agents; Chitosan; Delayed-Action Preparations; Fluorouracil; Gold; Humans; Hydrogen-Ion Concentration; Liver Neoplasms; Metal Nanoparticles; Nanocomposites; Nanogels; Silver | 2023 |
Chitosan-decorated and tripolyphosphate-crosslinked pH-sensitive niosomal nanogels for Controlled release of fluoropyrimidine 5-fluorouracil.
Topics: Animals; Antimetabolites; Chitosan; Delayed-Action Preparations; Drug Carriers; Fluorouracil; Hemolysis; Hydrogen-Ion Concentration; Mice; Nanogels; Nanoparticles; NIH 3T3 Cells; Particle Size | 2023 |
Dermatan Sulfate/Chitosan Nanoparticles Loaded with an Anti-Inflammatory Peptide Increase the Response of Human Colorectal Cancer Cells to 5-Fluorouracil.
Topics: Anti-Inflammatory Agents; Cell Line, Tumor; Chitosan; Colorectal Neoplasms; Dermatan Sulfate; Fluorouracil; Humans; Nanoparticles; NF-kappa B; Peptides | 2023 |
Insights into the Effect of Chitosan and β-Cyclodextrin Hybridization of Zeolite-A on Its Physicochemical and Cytotoxic Properties as a Bio-Carrier for 5-Fluorouracil: Equilibrium and Release Kinetics Studies.
Topics: Antineoplastic Agents; beta-Cyclodextrins; Chitosan; Drug Carriers; Fluorouracil; Kinetics; Zeolites | 2023 |
Targeted Anticancer Drug Delivery Using Chitosan, Carbon Quantum Dots, and Aptamers to Deliver Ganoderic Acid and 5-Fluorouracil.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Chitosan; Drug Delivery Systems; Female; Fluorouracil; Humans; Male; Quantum Dots; Spectroscopy, Fourier Transform Infrared | 2023 |
5-Fluorouracil and Anti-EGFR antibody scaffold chitosan-stabilized Pickering emulsion: Formulations, physical characterization, in-vitro studies in NCL-H226 cells, and in-vivo investigations in Wistar rats for the augmented therapeutic effects against squ
Topics: Animals; Carcinoma, Squamous Cell; Chitosan; Emulsions; Fluorouracil; Mice; Nanoparticles; Rats; Rats, Wistar | 2023 |