fluorouracil and aspartic acid

fluorouracil has been researched along with aspartic acid in 111 studies

Research

Studies (111)

Timeframe	Studies, this research(%)	All Research%
pre-1990	34 (30.63)	18.7374
1990's	62 (55.86)	18.2507
2000's	12 (10.81)	29.6817
2010's	2 (1.80)	24.3611
2020's	1 (0.90)	2.80

Authors

Authors	Studies
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y	1
Harstrick, A; Köhne-Wömpner, CH; Rustum, YM; Schmoll, HJ	1
Colofiore, JR; Koutcher, JA; Martin, DS; Nord, LD; Stolfi, RL	1
Coit, D; Colofiore, J; Kelsen, D; Martin, DS; Sawyer, R	1
Eisenberg, BL; Fowler, WC; Hoffman, JP	1
Stenram, U	1
Banerjee, TK; DiFino, SM; Engstrom, PF; Flynn, PJ; Heim, WJ; O'Dwyer, PJ; Ozols, RF; Rosvold, E; Schilder, R; Walczak, J	1
Hiddemann, W; Köhne-Wömpner, CH; Rustum, Y; Schmoll, HJ	1
Kemeny, NE; Martin, DS	2
Botet, J; Conti, JA; Costa, P; Kemeny, N; Martin, D; McCulloch, W; Niedzwiecki, D; Seiter, K; Wiseberg, J	1
Colofiore, J; Comis, RL; Hoffman, J; Hudes, GR; LaCreta, FP; Martin, DS; O'Dwyer, PJ; Ozols, RF; Walczak, J	1
Ardalan, B; Benedetto, P; Feun, L; Livingstone, A; Morrell, L; Reddy, R; Richman, S; Savaraj, N; Stridhar, K; Waldman, S	1
Costa, P; Kemeny, N; Kurtz, RC; Martin, D; Murray, M; Niedzwiecki, D; Seiter, K; Urmacher, C	1
Cheson, BD	1
Ardalan, B; Benedetto, P; Feun, L; Fodor, M; Livingstone, A; Morrell, L; Richman, S; Savaraj, N; Sridhar, KS; Waldman, S	1
Allegra, CJ	1
Bruckner, HW; Motwani, BT	1
Bach, A; Fleming, TR; Goodman, P; MacDonald, JS; Morrell, LM; Richman, SP	1
O'Dwyer, PJ	3
Goldberg, RM; Krook, JE; Kugler, JW; Laurie, JA; Moertel, CG; O'Connell, MJ; Pfeifle, DM; Rubin, J; Wieand, HS; Windschitl, HE	1
Comis, RL; Litwin, S; O'Dwyer, PJ; Paul, AR; Walczak, J; Weiner, LM	1
Martin, DS	3
Kemeny, NE; Martin, DS; Schneider, A	1
Colofiore, J; Derby, S; Kemeny, N; Martin, DS; Salvia, B; Sawyer, RC; Schneider, A	1
Laurensse, E; Leyva, A; Peters, GJ; Pinedo, HM	1
Buroker, TR; Cullinan, SA; Everson, LK; Fleming, TR; Klaassen, DJ; Krook, JE; Laurie, JA; Mailliard, JA; Marschke, RF; Moertel, CG	1
Hoth, DF; King, SA; Leyland-Jones, B; O'Dwyer, PJ	1
Ardalan, B; Silberman, H; Singh, G	1
Leyland-Jones, B; O'Dwyer, PJ	1
Martin, DS; Sawyer, RC; Stolfi, RL	1
Camacho, FJ; Engstrom, PF; Green, MD; Greenwald, ES; Kaplan, BH; Muggia, FM; Wernz, JC	1
Martin, DS; Sawyer, RC; Stolfi, RL; Young, CW	1
Akazawa, S; Ayusawa, D; Kumai, R; Seno, T; Shimizu, K; Yoshida, S	1
Bedikian, A; Bodey, GP; Chiuten, DF; Freireich, EJ; Valdivieso, M	1
Buzdar, AU; Hortobagyi, GN; Mann, GB; Valdivieso, M; Yap, HY	1
Bedikian, A; Benvenuto, JA; Bodey, GP; Chiuten, DF; Freireich, EJ; Loo, TL; Miller, A; Valdivieso, M	1
Jund, R; Lacroute, F	1
Gerhart, JC; O'Donovan, GA	1
Powis, G	1
Casper, ES; Martin, DS; Sawyer, RC; Spiegelman, S; Stolfi, RL; Young, CW	1
Benvenuto, JA; Hurlbert, RB; Loo, TL; Miller, AA; Moore, EC	1
Ehrlich, CE; Stehman, FB	1
Ardalan, B; Browning, S; Carr, BI; Chan, C; Chang, FF; Green, L; Multhauf, P; Presant, CA; Staples, R; Thayer, W	1
Ardalan, B; Jamin, D; Jayaram, HN; Presant, CA	1
Shapiro, WR; Young, DF	1
Hahn, RG; Kvols, LK; Moertel, CG; O'Connell, MJ; Rubin, J; Schutt, AJ	1
Lankelma, J; Laurensse, E; Leyva, A; Peters, GJ; Pinedo, HM	1
Martin, DS; Sawyer, RC; Spiegelman, S; Stolfi, RL; Young, CW	1
Casper, ES; Kemeny, N; Martin, DS; Michaelson, RA; Young, CW	1
Chabner, BA; Donehower, RC; Liang, CM	1
Casper, ES; Martin, DS; Vale, K; Williams, LJ; Young, CW	1
Chabner, BA; Donehower, RC; Erlichman, C; Klecker, R; Speyer, JL	1
Moertel, CG; O'Connell, MJ; Powis, G; Rubin, J	1
Ervin, TJ; Kufe, DW; Meshad, MW; Weiss, GR	1
Branfman, AR; Bruni, RJ; Chadwick, M; Ervin, TJ; Kufe, DW; Meshad, MW; Schade, D; Weiss, GR	1
Ardalan, B; Cooney, DA; Glazer, RI; Jayaram, HN; Kensler, TW; Macdonald, JS; Van Pham, T	1
Allegra, CJ; Grogan, L; Sotos, GA	1
Creaven, PJ; Meropol, NJ; Petrelli, NJ	1
Seitz, JF	1
Buyse, M; Le Bourgeois, JP; Lévy, E; Piedbois, P	1
Machover, D	1
Ardalan, B; Doroshow, JH; Fleming, TR; Holcombe, RF; Leichman, CG; Mangalik, A; Meyers, FJ; Muggia, FM; Tangen, CM; Weiss, GR	1
Green, F; Hoffman, JP; O'Dwyer, PJ; Redei, I; Scher, R; Weiner, LM	1
Brennan, J; Hageboutros, A; Hudes, GR; LaCreta, FP; McAleer, C; Newman, EM; O'Dwyer, PJ; Ozols, RF; Rogatko, A	1
Canney, PA; Cassidy, J; Jodrell, DI; Kaye, SB; Kerr, DJ; Oster, W; Steward, WP; Yosef, H	1
Heerschap, A; Hofs, HP; Kamm, VJ; Rietjens, IM; Rosenbusch, G; Vervoort, J; Wagener, DJ	1
Ardalan, B; Donofrio, K; Livingstone, AS; Markoe, A; Reddy, R; Richman, SP; Schwade, J; Ucar, A	1
Cao, S; Rustum, YM; Spector, T	1
Bajaj, R; Hallam, S; Mao, X; Schwartz, EL; Wadler, S	1
Arbuck, SG; Balis, F; Chisena, T; Cysyk, R; Drake, J; Grem, JL; Hamilton, JM; McAtee, N; Murphy, RF; Steinberg, SM	1
Ahlgren, JD; Anderson, N; Kemeny, N; Lokich, JJ	1
Hudes, GR; Kitson, J; Litwin, S; O'Dwyer, PJ; Walczak, J; Watts, P; Weiner, LM	1
Colofiore, J; Kemeny, N; Martin, D; Sawyer, R; Schneider, A; Seiter, K; Williams, L	1
Brennan, J; Colofiore, J; Green, F; Hageboutros, A; Hoffman, J; Hudes, GR; LaCreta, FP; Martin, DS; O'Dwyer, PJ; Ozols, RF	1
Colofiore, JR; Martin, DS; Nord, LD; Stolfi, RL	1
Gleissner, B; Haynes, H; Hilgenfeld, RU; Kaleya, R; Kreuser, ED; Rozenblit, A; Thiel, E; Wadler, S	1
Blomgren, H; Ragnhammar, P	1
Chernova, OB; Gilbert, C; Poupon, MF; Smith, KA; Stark, GR	1
Kinsella, AR; Pickard, M; Smith, D	1
Ardalan, B; Fleming, TR; Macdonald, JS; Martino, RL; Morrell, LM; Richman, SP	1
Brennan, J; Greene, F; Hageboutros, A; Hudes, GR; LaCreta, FP; O'Dwyer, PJ	1
Köhne, CH; Schmoll, HJ; Schöffski, P; Wilke, H	1
Berns, T; Harstrick, A; Hiddemann, W; Köhne, CH; Preusser, P; Schmoll, HJ; Seeber, S; Strumberg, D; Wilke, H	1
Alfieri, AA; Koutcher, JA; Martin, DS; Matei, C; Thaler, H	1
Gu, X; Huang, L; Pookanjanatavip, M; Santi, DV	1
Bokemeyer, C; Dörken, B; Harstrick, A; Hiddemann, W; Köhne, CH; Schmoll, HJ; Schöffski, P; Wilke, H	1
Ardalan, B; Franceschi, D; Jaime, M; Luis, R	1
Aks, C; Clark, J; DeMaria, D; Johnson, C; Langer, CJ; Leighton, J; Litwin, S; Reilly, DM; Ridge, JA; Sauter, E; Schaebler, D	1
Capizzi, RL; Case, L; Fernandes, DJ; Fleming, RA; Homesley, H; Loggie, BW; Morris, R; Muss, HB; Richards, F; Russell, GB; Smith, S	1
Brady, F; Brown, G; Harte, RJ; Jones, T; Luthra, SJ; Matthews, JC; O'Reilly, SM; Osman, S; Price, PM; Tilsley, DW	1
Belt, RJ; Bready, B; Dakhil, SR; Goodwin, JW; Gray, R; Hoff, PM; McGarry, W; Pazdur, R; Royce, ME; Winn, R	1
Büchele, T; Dempke, W; Grothey, A; Schmoll, HJ	1
Arbuck, SG; Benson, AB; Haller, DG; Hines, JD; Manola, J; Mayer, RJ; O'Dwyer, PJ; Ryan, LM; Valone, FH; Wadler, S; Weiner, LM	1
Elsaleh, H; Gnanasampanthan, G; Iacopetta, B; McCaul, K	1
Allegra, CJ; Chabuk, C; Chen, AP; Grabenc, M; Grem, JL; Grollman, F; Hamilton, JM; Schuler, B; Takimoto, CH; Yee, LK	1
Baron, B; Bleiberg, H; Blijham, GH; Couvreur, ML; De Greve, J; Genicot, B; Jansen, RL; Kok, TC; Nortier, JW; Wagener, T; Wils, J	1
Allegra, CJ; Benson, AB; Catalano, P; Johnston, PG; O'Dwyer, PJ; Rao, MS	1
Hwang, YH; Park, SP; Suh, CK	1
Lehnert, S; Li, Y; Owusu, A	1
Abbruzzese, JL; Ardalan, B; Balcerzak, SP; Benedetti, JK; Goodwin, JW; Lenz, HJ; Macdonald, JS; Samlowski, WE; Whitehead, RP	1
Abbruzzese, JL; Ardalan, B; Balcerzak, SP; Benedetti, JK; Gaynor, ER; Macdonald, JS; Whitehead, RP; Williamson, S	1
Kemeny, NE; Leonard, GD	1
Alberts, SR; Berenberg, JL; Diasio, RB; Goldberg, RM; Lee, AM; Pavey, E; Sargent, DJ; Shi, Q; Sinicrope, FA	1
Hong, D; Hong, KM; Kang, JH; Kim, SY; Lee, JS; Lee, SH; Son, J; Song, J	1
Han, FH; Hu, H; Huang, J; Luo, ML; Tan, JN; Yang, B; Zhang, W; Zhong, GY; Zhou, SN	1

Reviews

23 review(s) available for fluorouracil and aspartic acid

Article	Year
Chemotherapeutic strategies in metastatic colorectal cancer: an overview of current clinical trials. Seminars in oncology, 1992, Volume: 19, Issue:2 Suppl 3 Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cisplatin; Clinical Trials as Topic; Colorectal Neoplasms; Drug Administration Schedule; Fluorouracil; Humans; Infusions, Intravenous; Interferons; Leucovorin; Methotrexate; Phosphonoacetic Acid	1992
Overview of N-(phosphonacetyl)-L-aspartate + fluorouracil in clinical trials. Seminars in oncology, 1992, Volume: 19, Issue:2 Suppl 3 Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Clinical Trials as Topic; Drug Administration Schedule; Drug Synergism; Fluorouracil; Forecasting; Humans; Phosphonoacetic Acid	1992
Modulation of fluorouracil by N-(phosphonacetyl)-L-asparate: a review. Seminars in oncology, 1992, Volume: 19, Issue:2 Suppl 3 Topics: Animals; Antimetabolites, Antineoplastic; Aspartic Acid; Clinical Trials as Topic; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Phosphonoacetic Acid; RNA, Neoplasm; Thymidylate Synthase; Uridine Triphosphate	1992
Chemotherapy of advanced cancer of the colon and rectum. Seminars in oncology, 1991, Volume: 18, Issue:5 Topics: Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colonic Neoplasms; Fluorouracil; Humans; Leucovorin; Methotrexate; Phosphonoacetic Acid; Rectal Neoplasms	1991
The role of low-dose PALA in biochemical modulation. Pharmacology & therapeutics, 1990, Volume: 48, Issue:3 Topics: Animals; Antineoplastic Agents; Aspartic Acid; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Evaluation; Fluorouracil; Humans; Neoplasms; Neoplasms, Experimental; Phosphonoacetic Acid; Pyrimidines	1990
Role of thymidine in biochemical modulation: a review. Cancer research, 1987, Aug-01, Volume: 47, Issue:15 Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cytarabine; Deoxycytidine Kinase; DNA Replication; DNA, Neoplasm; Drug Evaluation; Drug Synergism; Fluorouracil; Folic Acid Antagonists; Humans; Interphase; Kinetics; Leukemia; Methotrexate; Mice; Neoplasms; Neoplasms, Experimental; Nucleic Acid Synthesis Inhibitors; Nucleotides; Phosphonoacetic Acid; RNA, Neoplasm; Species Specificity; Thymidine	1987
Biochemical modulation: application of laboratory models to the clinic. Cancer treatment reports, 1986, Volume: 70, Issue:1 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cytarabine; Dose-Response Relationship, Drug; Drug Evaluation; Fluorouracil; Humans; Methotrexate; Neoplasms, Experimental; Organophosphorus Compounds; Phosphonoacetic Acid; Thymidine	1986
Application of biochemical modulation with a therapeutically inactive modulating agent in clinical trials of cancer chemotherapy. Cancer treatment reports, 1985, Volume: 69, Issue:4 Topics: Animals; Aspartic Acid; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fluorouracil; Humans; Neoplasms; Organophosphorus Compounds; Phosphonoacetic Acid	1985
Effect of human renal and hepatic disease on the pharmacokinetics of anticancer drugs. Cancer treatment reviews, 1982, Volume: 9, Issue:2 Topics: Antineoplastic Agents; Aspartic Acid; Bleomycin; Cisplatin; Cyclophosphamide; Doxorubicin; Fluorouracil; Gallium; Humans; Kidney Diseases; Kinetics; Liver Diseases; Metabolic Clearance Rate; Methotrexate; Phosphonoacetic Acid; Protein Binding; Tegafur	1982
Neurological complications of antineoplastic therapy. Acta neurologica Scandinavica. Supplementum, 1984, Volume: 100 Topics: Adrenal Cortex Hormones; Alkylating Agents; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Aspartic Acid; Cisplatin; Cytarabine; Fluorouracil; Humans; Methotrexate; Nervous System Diseases; Phosphonoacetic Acid; Thymidine; Vinblastine; Vincristine	1984
Preclinical and clinical aspects of biomodulation of 5-fluorouracil. Cancer treatment reviews, 1994, Volume: 20, Issue:1 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cisplatin; Colorectal Neoplasms; DNA, Neoplasm; Fluorouracil; Humans; Idoxuridine; Immunologic Factors; Interferons; Leucovorin; Methotrexate; Mice; Phosphonoacetic Acid; RNA, Neoplasm; Uracil; Uridine; Zidovudine	1994
Biochemical modulation as an approach to reversal of antimetabolite resistance. Cancer treatment and research, 1994, Volume: 73 Topics: Antimetabolites, Antineoplastic; Aspartic Acid; Clinical Trials as Topic; Colorectal Neoplasms; Drug Design; Drug Resistance, Multiple; Fluorouracil; Humans; Interferons; Methylthioinosine; Multicenter Studies as Topic; Phosphonoacetic Acid; Purines; Pyrimidines; Thymidylate Synthase; Tumor Cells, Cultured	1994
Metastatic colorectal cancer: advances in biochemical modulation and new drug development. Seminars in oncology, 1995, Volume: 22, Issue:5 Topics: Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cisplatin; Colorectal Neoplasms; Diarrhea; Digestive System; Drug Administration Schedule; Fluorouracil; Gastrointestinal Agents; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interferon-alpha; Leucovorin; Octreotide; Phosphonoacetic Acid; Prodrugs; Randomized Controlled Trials as Topic; Thymidylate Synthase; Topoisomerase I Inhibitors	1995
[Chemotherapy in cancers of the colon]. Gastroenterologie clinique et biologique, 1993, Volume: 17, Issue:2 Pt 3 Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Chemotherapy, Adjuvant; Colonic Neoplasms; Fluorouracil; Humans; Immunotherapy; Interferons; Interleukin-2; Leucovorin; Phosphonoacetic Acid	1993
[Chemotherapy of metastasizing cancers of the colon and rectum]. Annales de chirurgie, 1993, Volume: 47, Issue:6 Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colonic Neoplasms; Fluorouracil; Humans; Interferons; Leucovorin; Methotrexate; Neoplasm Metastasis; Phosphonoacetic Acid; Rectal Neoplasms	1993
The pharmacologic modulation of 5-fluorouracil with folinic acid, methotrexate, trimetrexate, and n-phosphonacetyl-l-aspartic acid (PALA). Mechanisms of the interactions and clinical data. Bulletin du cancer, 1994, Volume: 81 Suppl 2 Topics: Aspartic Acid; Drug Interactions; Fluorouracil; Humans; Leucovorin; Methotrexate; Neoplasms; Phosphonoacetic Acid; Trimetrexate	1994
Biochemical modulation of 5-fluorouracil by PALA: mechanism of action. Advances in experimental medicine and biology, 1993, Volume: 339 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug Synergism; Fluorouracil; Humans; Immunologic Factors; Phosphonoacetic Acid	1993
Recent advances in the treatment of advanced colorectal cancer. Cancer, 1993, Jan-01, Volume: 71, Issue:1 Topics: Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Drug Administration Schedule; Drug Interactions; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Hydroxyurea; Infusions, Intra-Arterial; Leucovorin; Methotrexate; Neoplasm Staging; Phosphonoacetic Acid; Prospective Studies; Randomized Controlled Trials as Topic	1993
How to optimize the effect of 5-fluorouracil modulated therapy in advanced colorectal cancer. Medical oncology (Northwood, London, England), 1995, Volume: 12, Issue:3 Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Clinical Trials as Topic; Colorectal Neoplasms; Fluorouracil; Humans; Interferons; Leucovorin; Liver Neoplasms; Methotrexate; Phosphonoacetic Acid	1995
Resistance to chemotherapeutic antimetabolites: a function of salvage pathway involvement and cellular response to DNA damage. British journal of cancer, 1997, Volume: 75, Issue:7 Topics: Animals; Antimetabolites, Antineoplastic; Aspartic Acid; DNA Damage; Drug Resistance; Fluorouracil; Humans; Methotrexate; Phosphonoacetic Acid; Purines; Pyrimidines; Tumor Suppressor Protein p53	1997
The dead end of 5-fluorouracil double modulation and promise of continuous infusion schedules in the treatment of metastatic colorectal cancer. The Journal of infusional chemotherapy, 1996,Fall, Volume: 6, Issue:4 Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Aspartate Carbamoyltransferase; Aspartic Acid; Clinical Trials, Phase II as Topic; Colorectal Neoplasms; Combined Modality Therapy; Dipyridamole; Drug Administration Schedule; Drug Synergism; Enzyme Inhibitors; Female; Fluorouracil; Humans; Immunologic Factors; Infusions, Intravenous; Injections, Intravenous; Interferons; Leucovorin; Liver Neoplasms; Male; Methotrexate; Middle Aged; Multicenter Studies as Topic; Neoplasm Proteins; Nucleotides; Palliative Care; Phosphonoacetic Acid; Randomized Controlled Trials as Topic; Thymidylate Synthase	1996
Biomodulation of Fluorouracil in colorectal cancer. Cancer investigation, 1998, Volume: 16, Issue:4 Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Clinical Trials as Topic; Colorectal Neoplasms; Drug Synergism; Fluorouracil; Humans; Interferon-alpha; Leucovorin; Methotrexate; Phosphonoacetic Acid; Trimetrexate	1998
Where do we stand with 5-fluorouracil? Seminars in oncology, 1999, Volume: 26, Issue:6 Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Chronotherapy; Colorectal Neoplasms; Dipyridamole; Drug Synergism; Fluorouracil; Humans; Interferons; Leucovorin; Levamisole; Methotrexate; Phosphonoacetic Acid; Radiation-Sensitizing Agents; Trimetrexate; Zidovudine	1999

Trials

31 trial(s) available for fluorouracil and aspartic acid

Article	Year
A phase II trial of biochemical modulation using N-phosphonacetyl-L-aspartate, high-dose methotrexate, high-dose 5-fluorouracil, and leucovorin in patients with adenocarcinoma of unknown primary site. Cancer, 1992, Oct-01, Volume: 70, Issue:7 Topics: Adenocarcinoma; Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Drug Evaluation; Female; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasms, Unknown Primary; Phosphonoacetic Acid; Phosphoribosyl Pyrophosphate; Uridine Triphosphate	1992
Phase II trial of PALA in combination with 5-fluorouracil in advanced pancreatic cancer. Cancer chemotherapy and pharmacology, 1992, Volume: 29, Issue:4 Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Drug Evaluation; Female; Fluorouracil; Humans; Infusions, Intravenous; Male; Pancreatic Neoplasms; Phosphonoacetic Acid; Survival Analysis	1992
Phase I trial of fluorouracil modulation by N-phosphonacetyl-L-aspartate and 6-methylmercaptopurine riboside: optimization of 6-methylmercaptopurine riboside dose and schedule through biochemical analysis of sequential tumor biopsy specimens. Journal of the National Cancer Institute, 1991, Sep-04, Volume: 83, Issue:17 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Biopsy; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation; Drug Interactions; Female; Fluorouracil; Humans; Male; Methylthioinosine; Middle Aged; Neoplasms; Phosphonoacetic Acid; Phosphoribosyl Pyrophosphate	1991
A new syndrome: ascites, hyperbilirubinemia, and hypoalbuminemia after biochemical modulation of fluorouracil with N-phosphonacetyl-L-aspartate (PALA) Annals of internal medicine, 1991, Dec-15, Volume: 115, Issue:12 Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Ascites; Aspartic Acid; Colorectal Neoplasms; Drug Evaluation; Fluorouracil; Humans; Hyperbilirubinemia; Liver Neoplasms; Male; Phosphonoacetic Acid; Prothrombin Time; Retrospective Studies; Serum Albumin; Syndrome; Transaminases	1991
A phase I, II study of high-dose 5-fluorouracil and high-dose leucovorin with low-dose phosphonacetyl-L-aspartic acid in patients with advanced malignancies. Cancer, 1991, Sep-15, Volume: 68, Issue:6 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Breast Neoplasms; Drug Evaluation; Female; Fluorouracil; Gastrointestinal Diseases; Gastrointestinal Neoplasms; Humans; Leucovorin; Lung Neoplasms; Male; Middle Aged; Neoplasms; Phosphonoacetic Acid; Prognosis	1991
A phase II multi-institutional trial of low-dose N-(phosphonacetyl)-L-aspartate and high-dose 5-fluorouracil as a short-term infusion in the treatment of adenocarcinoma of the pancreas. A Southwest Oncology Group study. Cancer, 1991, Jan-15, Volume: 67, Issue:2 Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Drug Administration Schedule; Drug Evaluation; Drug Synergism; Female; Fluorouracil; Humans; Male; Middle Aged; Pancreatic Neoplasms; Phosphonoacetic Acid; Survival Rate	1991
A clinical trial of biochemical modulation of 5-fluorouracil with N-phosphonoacetyl-L-aspartate and thymidine in advanced gastric and anaplastic colorectal cancer. Cancer, 1990, Sep-01, Volume: 66, Issue:5 Topics: Adult; Aged; Aspartic Acid; Clinical Trials as Topic; Colorectal Neoplasms; Drug Evaluation; Drug Synergism; Female; Fluorouracil; Follow-Up Studies; Humans; Male; Middle Aged; Phosphonoacetic Acid; Stomach Neoplasms; Thymidine	1990
A controlled evaluation of recent approaches to biochemical modulation or enhancement of 5-fluorouracil therapy in colorectal carcinoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1985, Volume: 3, Issue:12 Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colonic Neoplasms; Drug Evaluation; Female; Fluorouracil; Humans; Levamisole; Male; Middle Aged; Neoplasm Metastasis; Phosphonoacetic Acid; Random Allocation; Rectal Neoplasms; Semustine; Streptozocin; Thymidine; Vincristine	1985
A randomized phase I and II study of short-term infusion of high-dose fluorouracil with or without N-(phosphonacetyl)-L-aspartic acid in patients with advanced pancreatic and colorectal cancers. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1988, Volume: 6, Issue:6 Topics: Adult; Aged; Antineoplastic Agents; Aspartic Acid; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Fluorouracil; Humans; Male; Middle Aged; Organophosphorus Compounds; Pancreatic Neoplasms; Phosphonoacetic Acid; Random Allocation; Rectal Neoplasms	1988
Application of biochemical modulation with a therapeutically inactive modulating agent in clinical trials of cancer chemotherapy. Cancer treatment reports, 1985, Volume: 69, Issue:4 Topics: Animals; Aspartic Acid; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fluorouracil; Humans; Neoplasms; Organophosphorus Compounds; Phosphonoacetic Acid	1985
A comparative study of PALA, PALA plus 5-FU, and 5-FU in advanced breast cancer. Cancer, 1985, Sep-15, Volume: 56, Issue:6 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Breast Neoplasms; Female; Fluorouracil; Humans; Middle Aged; Neoplasm Metastasis; Organophosphorus Compounds; Phosphonoacetic Acid; Random Allocation	1985
The pharmacologic modulation of 5-fluorouracil with folinic acid, methotrexate, trimetrexate, and n-phosphonacetyl-l-aspartic acid (PALA). Mechanisms of the interactions and clinical data. Bulletin du cancer, 1994, Volume: 81 Suppl 2 Topics: Aspartic Acid; Drug Interactions; Fluorouracil; Humans; Leucovorin; Methotrexate; Neoplasms; Phosphonoacetic Acid; Trimetrexate	1994
Phase II study of fluorouracil and its modulation in advanced colorectal cancer: a Southwest Oncology Group study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1995, Volume: 13, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Agranulocytosis; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Diarrhea; Drug Administration Schedule; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Recurrence, Local; Phosphonoacetic Acid; Survival Rate	1995
Phase II trial of PALA and 6-methylmercaptopurine riboside (MMPR) in combination with 5-fluorouracil in advanced pancreatic cancer. Investigational new drugs, 1994, Volume: 12, Issue:4 Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartate Carbamoyltransferase; Aspartic Acid; Female; Fluorouracil; Humans; Male; Methylthioinosine; Middle Aged; Pancreatic Neoplasms; Phosphonoacetic Acid	1994
Phase I study of phosphonacetyl-L-aspartate, 5-fluorouracil, and leucovorin in patients with advanced cancer. Cancer chemotherapy and pharmacology, 1995, Volume: 35, Issue:3 Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Diarrhea; Digestive System; Drug Synergism; Female; Fluorouracil; Folic Acid; Humans; Leucovorin; Male; Middle Aged; Neoplasms; Neutropenia; Phosphonoacetic Acid; Proportional Hazards Models; Pyrimidines; Remission Induction; Risk Factors; Thymidylate Synthase	1995
A phase I-II study of N-(phosphonacetyl)-L-aspartic acid (PALA) added to 5-fluorouracil and folinic acid in advanced colorectal cancer. European journal of cancer (Oxford, England : 1990), 1994, Volume: 30A, Issue:7 Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colonic Neoplasms; Disease Progression; Dose-Response Relationship, Drug; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Phosphonoacetic Acid; Rectal Neoplasms	1994
Phase I trial of low dose N-phosphonacetyl-L-aspartic acid and high dose 5-fluorouracil administered concomitantly with radiation therapy for unresectable localized adenocarcinoma of the pancreas. Cancer, 1994, Oct-01, Volume: 74, Issue:7 Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Combined Modality Therapy; Feasibility Studies; Female; Fluorouracil; Humans; Male; Middle Aged; Pancreatic Neoplasms; Phosphonoacetic Acid; Radiotherapy Dosage	1994
A phase I study of continuous infusion 5-fluorouracil plus calcium leucovorin in combination with N-(phosphonacetyl)-L-aspartate in metastatic gastrointestinal adenocarcinoma. Cancer research, 1993, Oct-15, Volume: 53, Issue:20 Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aspartate Carbamoyltransferase; Aspartic Acid; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Monocytes; Neoplasm Metastasis; Phosphonoacetic Acid	1993
Phase I trial of fluorouracil modulation by N-phosphonacetyl-L-aspartate and 6-methylmercaptopurine ribonucleoside. Cancer chemotherapy and pharmacology, 1996, Volume: 37, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Agents; Aspartic Acid; Female; Fluorouracil; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Phosphonoacetic Acid; RNA, Neoplasm; Thioinosine; Thionucleotides	1996
Phase II trial of N-(phosphonacetyl)-L-aspartate (PALA), 5-fluorouracil and recombinant interferon-alpha-2b in patients with advanced gastric carcinoma. European journal of cancer (Oxford, England : 1990), 1996, Volume: 32A, Issue:7 Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Fluorouracil; Humans; Interferon alpha-2; Interferon-alpha; Middle Aged; Phosphonoacetic Acid; Recombinant Proteins; Stomach Neoplasms	1996
Phase II trial of low-dose N-(phosphonacetyl)-disodium L-aspartic acid and high-dose 24-hour infusional 5-fluorouracil in advanced gastric adenocarcinoma. A Southwest Oncology Group study. Investigational new drugs, 1996, Volume: 14, Issue:4 Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Female; Fluorouracil; Humans; Infusions, Intravenous; Male; Middle Aged; Phosphonoacetic Acid; Stomach Neoplasms; Survival Rate	1996
Phase I trial of fluorouracil modulation by N-phosphonacetyl-L-aspartate and 6-methylmercaptopurine ribonucleoside (MMPR), and leucovorin in patients with advanced cancer. Investigational new drugs, 1997, Volume: 15, Issue:2 Topics: Adult; Aged; Antimetabolites, Antineoplastic; Aspartic Acid; Colorectal Neoplasms; Drug Interactions; Female; Fluorouracil; Humans; Leucovorin; Male; Methylthioinosine; Middle Aged; Phosphonoacetic Acid	1997
Modulation of 5-fluorouracil with methotrexate and low-dose N-(phosphonacetyl)-L-aspartate in patients with advanced colorectal cancer. Results of a phase II study. European journal of cancer (Oxford, England : 1990), 1997, Volume: 33, Issue:11 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Female; Fluorouracil; Humans; Male; Methotrexate; Middle Aged; Phosphonoacetic Acid; Survival Analysis; Treatment Outcome	1997
Phase II study of N-phosphonacetyl-L-aspartate, recombinant interferon-alpha, and fluorouracil infusion in advanced squamous cell carcinoma of the head and neck. Head & neck, 1998, Volume: 20, Issue:5 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Carcinoma, Squamous Cell; Drug Administration Schedule; Female; Fluorouracil; Genes, p53; Head and Neck Neoplasms; Humans; Interferon-alpha; Male; Middle Aged; Mutation; Neoplasm Recurrence, Local; Phosphonoacetic Acid; Survival Analysis; Treatment Failure	1998
Phase I study of N-(phosphonacetyl)-L-aspartate with fluorouracil and with or without dipyridamole in patients with advanced cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 1996, Volume: 2, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Aspartate Carbamoyltransferase; Aspartic Acid; Dipyridamole; Dose-Response Relationship, Drug; Female; Fluorouracil; Humans; Leukocytes; Male; Middle Aged; Neoplasms; Phosphonoacetic Acid; Uridine Triphosphate	1996
Sequential biochemical modulation of fluorouracil with folinic acid, N-phosphonacetyl-L-aspartic acid, and interferon alfa-2a in advanced colorectal cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1999, Volume: 17, Issue:10 Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Agents; Aspartic Acid; Colorectal Neoplasms; Combined Modality Therapy; Drug Administration Schedule; Drug Interactions; Female; Fluorouracil; Humans; Immunologic Factors; Infusions, Intravenous; Injections, Intravenous; Injections, Subcutaneous; Interferon-alpha; Leucovorin; Male; Middle Aged; Phosphonoacetic Acid; Survival Analysis; Treatment Outcome	1999
Fluorouracil modulation in colorectal cancer: lack of improvement with N -phosphonoacetyl- l -aspartic acid or oral leucovorin or interferon, but enhanced therapeutic index with weekly 24-hour infusion schedule--an Eastern Cooperative Oncology Group/Cance Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, May-01, Volume: 19, Issue:9 Topics: Administration, Oral; Aged; Antineoplastic Agents; Aspartic Acid; Colorectal Neoplasms; Female; Fluorouracil; Humans; Infusions, Intravenous; Interferon alpha-2; Interferon-alpha; Leucovorin; Male; Middle Aged; Phosphonoacetic Acid; Prognosis; Recombinant Proteins	2001
High-dose 5-fluorouracil plus low dose methotrexate plus or minus low-dose PALA in advanced colorectal cancer: a randomised phase II-III trial of the EORTC Gastrointestinal Group. European journal of cancer (Oxford, England : 1990), 2003, Volume: 39, Issue:3 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Disease-Free Survival; Female; Fluorouracil; Humans; Male; Methotrexate; Middle Aged; Phosphonoacetic Acid; Survival Analysis; Treatment Outcome	2003
A phase II study of high-dose 24 hour continuous infusion 5-FU and leucovorin and low-dose PALA for patients with advanced pancreatic adenocarcinoma: a Southwest Oncology Group Study. Investigational new drugs, 2004, Volume: 22, Issue:3 Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Pancreatic Neoplasms; Phosphonoacetic Acid; Pilot Projects; Prospective Studies; Survival Rate; Treatment Outcome	2004
A phase II pilot study of high-dose 24-hour continuous infusion of 5-FU and leucovorin and low-dose PALA for patients with colorectal cancer: a Southwest Oncology Group study. Investigational new drugs, 2004, Volume: 22, Issue:4 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Dose-Response Relationship, Drug; Female; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Phosphonoacetic Acid; Pilot Projects; Survival Rate; Treatment Outcome	2004
DPYD variants as predictors of 5-fluorouracil toxicity in adjuvant colon cancer treatment (NCCTG N0147). Journal of the National Cancer Institute, 2014, Volume: 106, Issue:12 Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Camptothecin; Chemotherapy, Adjuvant; Colonic Neoplasms; Diarrhea; Dihydrouracil Dehydrogenase (NADP); Drug-Related Side Effects and Adverse Reactions; Female; Fluorouracil; Genetic Predisposition to Disease; Humans; Leucovorin; Logistic Models; Male; Middle Aged; Nausea; Neoplasm Staging; Neutropenia; Organoplatinum Compounds; Polymorphism, Single Nucleotide; Prospective Studies; Severity of Illness Index; Thrombocytopenia; Valine; Vomiting	2014

Other Studies

59 other study(ies) available for fluorouracil and aspartic acid

Article	Year
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22 Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption	2007
Biochemical modulation of tumor cell energy: regression of advanced spontaneous murine breast tumors with a 5-fluorouracil-containing drug combination. Cancer research, 1992, Aug-01, Volume: 52, Issue:15 Topics: 6-Aminonicotinamide; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Female; Fluorouracil; Mammary Neoplasms, Experimental; Methylthioinosine; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Orotic Acid; Phosphonoacetic Acid; Phosphoribosyl Pyrophosphate	1992
Hepatic resection following systemic chemotherapy for metastatic colorectal carcinoma. Journal of surgical oncology, 1992, Volume: 51, Issue:2 Topics: Aged; Antineoplastic Agents; Aspartic Acid; Colorectal Neoplasms; Female; Fluorouracil; Hepatectomy; Humans; Leucovorin; Liver Neoplasms; Male; Neoplasm Recurrence, Local; Phosphonoacetic Acid; Retrospective Studies; Time Factors	1992
Hepatotoxicity of fluorouracil with N-phosphonacetyl-L-aspartate. Annals of internal medicine, 1992, Jul-01, Volume: 117, Issue:1 Topics: Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Chemical and Drug Induced Liver Injury; Fluorouracil; Humans; Phosphonoacetic Acid	1992
The emerging role for biomodulation of antineoplastic agents. Seminars in oncology, 1992, Volume: 19, Issue:2 Suppl 3 Topics: Antineoplastic Agents; Aspartic Acid; Dipyridamole; Fluorouracil; Humans; Immunologic Factors; Interferon-alpha; Phosphonoacetic Acid	1992
Biochemical modulation of bolus fluorouracil by PALA in patients with advanced colorectal cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1992, Volume: 10, Issue:5 Topics: Adenocarcinoma; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Female; Fluorouracil; Humans; Injections, Intravenous; Leukocyte Count; Male; Middle Aged; Phosphonoacetic Acid	1992
Phase I study of high dose 5-fluorouracil and high dose Leucovorin with low dose phosphonacetyl-L-aspartic acid in patients with advanced malignancies. International journal of radiation oncology, biology, physics, 1992, Volume: 22, Issue:3 Topics: Adult; Aged; Antineoplastic Agents; Aspartic Acid; Drug Evaluation; Female; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Neoplasms; Phosphonoacetic Acid	1992
Clinical trials referral resource. Treatment of advanced colorectal cancer. Oncology (Williston Park, N.Y.), 1991, Volume: 5, Issue:4 Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Clinical Trials as Topic; Colorectal Neoplasms; Fluorouracil; Humans; Leucovorin; Phosphonoacetic Acid	1991
Biochemical modulation: a modality that has come of therapeutic age. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1991, Volume: 9, Issue:10 Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Breast Neoplasms; Female; Fluorouracil; Humans; Leucovorin; Mitoxantrone; Phosphonoacetic Acid	1991
Phase II study of biochemical modulation of fluorouracil by low-dose PALA in patients with colorectal cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1990, Volume: 8, Issue:9 Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Fluorouracil; Humans; Male; Middle Aged; Phosphonoacetic Acid; Survival Analysis	1990
Introduction to 5-fluorouracil modulation. Cancer investigation, 1990, Volume: 8, Issue:2 Topics: Antimetabolites, Antineoplastic; Aspartic Acid; Drug Interactions; Fluorouracil; Humans; Leucovorin; Methotrexate; Phosphonoacetic Acid; Uridine	1990
Biochemical modulation of 5-fluorouracil by PALA. Cancer investigation, 1990, Volume: 8, Issue:2 Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Drug Evaluation; Drug Synergism; Fluorouracil; Humans; Phosphonoacetic Acid	1990
Phase I trial of PALA, methotrexate, fluorouracil, leucovorin, and uridine rescue in patients with advanced cancer. The use of uridine to decrease fluorouracil toxicity. Cancer investigation, 1990, Volume: 8, Issue:2 Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Drug Evaluation; Female; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasms; Phosphonoacetic Acid; Uridine	1990
Phase I trial of N-(phosphonacetyl)-L-aspartate, methotrexate, and 5-fluorouracil with leucovorin rescue in patients with advanced cancer. Cancer research, 1989, Aug-15, Volume: 49, Issue:16 Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Bone Marrow; Carcinoma, Squamous Cell; Colorectal Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Leucovorin; Male; Methotrexate; Pentosephosphates; Phosphonoacetic Acid; Phosphoribosyl Pyrophosphate	1989
The concentration of 5-phosphoribosyl 1-pyrophosphate in monolayer tumor cells and the effect of various pyrimidine antimetabolites. The International journal of biochemistry, 1985, Volume: 17, Issue:1 Topics: Animals; Aspartic Acid; Cell Line; Cells, Cultured; Fluorouracil; Humans; Methotrexate; Neoplasms; Ornithine Decarboxylase; Orotate Phosphoribosyltransferase; Pentosephosphates; Phosphonoacetic Acid; Phosphoribosyl Pyrophosphate	1985
Failure of L-histidinol to improve the therapeutic efficiency of 5-fluorouracil against murine breast tumors. Cancer research, 1987, Jan-01, Volume: 47, Issue:1 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cell Cycle; Female; Fluorouracil; Histidinol; Imidazoles; Lethal Dose 50; Leukemia L1210; Mammary Neoplasms, Experimental; Mice; Mice, Inbred Strains; Phosphonoacetic Acid	1987
Weekly 5-fluorouracil combined with PALA: toxic and therapeutic effects in colorectal cancer. Cancer treatment reports, 1987, Volume: 71, Issue:3 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Central Nervous System Diseases; Colonic Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Gastrointestinal Diseases; Hematologic Diseases; Humans; Male; Middle Aged; Neoplasm Metastasis; Phosphonoacetic Acid; Pilot Projects; Rectal Neoplasms	1987
Cancer chemotherapy: past is prologue. The Mount Sinai journal of medicine, New York, 1985, Volume: 52, Issue:6 Topics: 6-Aminonicotinamide; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Female; Fluorouracil; Humans; Male; Mammary Neoplasms, Experimental; Methotrexate; Methylthioinosine; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Phosphonoacetic Acid	1985
[Biochemical modulation of 5-FU by thymidine and N-phosphoacetyl-L-aspartate: the relation between 5-FU incorporation into RNA and its cytocidal effect]. Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:4 Pt 1 Topics: Animals; Aspartic Acid; Cell Division; Cell Survival; Cells, Cultured; DNA, Neoplasm; Drug Synergism; Female; Fluorouracil; Mammary Neoplasms, Experimental; Mice; Organophosphorus Compounds; Phosphonoacetic Acid; RNA, Neoplasm; Thymidine; Tumor Stem Cell Assay	1986
Phase I-II clinical trial of thymidine, 5-FU, and PALA given in combination. Cancer treatment reports, 1985, Volume: 69, Issue:6 Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colonic Neoplasms; Drug Evaluation; Fluorouracil; Humans; Middle Aged; Phosphonoacetic Acid; Rectal Neoplasms; Thymidine	1985
Sequential administration of thymidine, 5-fluorouracil, and PALA. A phase I-II study. American journal of clinical oncology, 1985, Volume: 8, Issue:4 Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Carcinoma, Bronchogenic; Chromatography, High Pressure Liquid; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Fluorouracil; Half-Life; Humans; Infusions, Parenteral; Middle Aged; Organophosphorus Compounds; Phosphonoacetic Acid; Stomach Neoplasms; Thymidine	1985
Regulation of orotidylic acid pyrophosphorylase in Saccharomyces cerevisiae. Journal of bacteriology, 1972, Volume: 109, Issue:1 Topics: Amidohydrolases; Amino Acids; Aspartic Acid; Carbamates; Carboxy-Lyases; Cell-Free System; Culture Media; Enzyme Induction; Enzyme Repression; Fluorouracil; Genes; Genetic Complementation Test; Genetics, Microbial; Mutation; Orotic Acid; Oxidoreductases; Pentosyltransferases; Pyrimidines; Saccharomyces; Saccharomyces cerevisiae; Spectrophotometry; Transferases; Uracil; Uracil Nucleotides	1972
Isolation and partial characterization of regulatory mutants of the pyrimidine pathway in Salmonella typhimurium. Journal of bacteriology, 1972, Volume: 109, Issue:3 Topics: Aspartic Acid; Centrifugation, Density Gradient; Chromosome Mapping; Culture Media; Cytosine Nucleotides; Drug Resistance, Microbial; Feedback; Fluorine; Fluorouracil; Genetics, Microbial; Mutation; Nucleotides; Orotic Acid; Oxidoreductases; Phosphorus; Phosphorus Isotopes; Pyrimidines; Salmonella typhimurium; Transduction, Genetic; Transferases; Uridine	1972
Therapeutic utility of utilizing low doses of N-(phosphonacetyl)-L-aspartic acid in combination with 5-fluorouracil: a murine study with clinical relevance. Cancer research, 1983, Volume: 43, Issue:5 Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Drug Therapy, Combination; Female; Fluorouracil; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Organophosphorus Compounds; Phosphonoacetic Acid; RNA	1983
Pharmacological and biochemical interactions of N-(phosphonacetyl)-L-aspartate and 5-fluorouracil in beagles. Cancer research, 1983, Volume: 43, Issue:6 Topics: Animals; Aspartic Acid; Blood Proteins; Dogs; Drug Interactions; Fluorouracil; Kinetics; Organophosphorus Compounds; Phosphonoacetic Acid; Pyrimidines; RNA; Tissue Distribution	1983
Peritoneo-cystic shunt for malignant ascites. Gynecologic oncology, 1984, Volume: 18, Issue:3 Topics: Ascites; Aspartic Acid; Combined Modality Therapy; Female; Fluorouracil; Humans; Middle Aged; Ovarian Neoplasms; Palliative Care; Peritoneum; Phosphonoacetic Acid; Suction; Tamoxifen; Urinary Bladder	1984
Continuous five-day infusion of PALA and 5FU: a pilot phase II trial. Medical and pediatric oncology, 1983, Volume: 11, Issue:3 Topics: Adult; Aged; Aspartic Acid; Carcinoma; Colonic Neoplasms; Drug Administration Schedule; Drug Eruptions; Drug Evaluation; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Middle Aged; Organophosphorus Compounds; Phosphonoacetic Acid; Rectal Neoplasms; Sarcoma	1983
Phase I study of continuous-infusion PALA and 5-FU. Cancer treatment reports, 1984, Volume: 68, Issue:3 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartate Carbamoyltransferase; Aspartic Acid; Breast Neoplasms; Colonic Neoplasms; Diarrhea; Digestive System; Dose-Response Relationship, Drug; Drug Eruptions; Drug Evaluation; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Phosphonoacetic Acid	1984
Clinical trial of sequential N-phosphonacetyl-L-aspartate, thymidine, and 5-fluorouracil in advanced colorectal carcinoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1984, Volume: 2, Issue:10 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Ataxia; Colonic Neoplasms; Confusion; Drug Administration Schedule; Drug Evaluation; Female; Fluorouracil; Humans; Infusions, Parenteral; Male; Middle Aged; Phosphonoacetic Acid; Rectal Neoplasms; Thymidine	1984
Separation of several 5-fluorouracil metabolites in various melanoma cell lines. Evidence for the synthesis of 5-fluorouracil-nucleotide sugars. European journal of cancer & clinical oncology, 1984, Volume: 20, Issue:11 Topics: Animals; Aspartic Acid; Cell Line; Cells, Cultured; Chromatography; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Fluorouracil; Humans; Melanoma; Mice; Phosphonoacetic Acid; RNA, Neoplasm; Uracil Nucleotides; Uridine; Uridine Triphosphate	1984
Improved therapeutic index with sequential N-phosphonacetyl-L-aspartate plus high-dose methotrexate plus high-dose 5-fluorouracil and appropriate rescue. Cancer research, 1983, Volume: 43, Issue:10 Topics: Animals; Antineoplastic Agents; Aspartic Acid; Drug Therapy, Combination; Female; Fluorouracil; Leucovorin; Male; Methotrexate; Mice; Neoplasms; Organophosphorus Compounds; Phosphonoacetic Acid; Uridine	1983
Phase I evaluation of a biochemically designed combination: PALA, thymidine, and 5-FU. Cancer treatment reports, 1984, Volume: 68, Issue:3 Topics: Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Drug Evaluation; Fluorouracil; Humans; Neoplasms; Nervous System; Phosphonoacetic Acid; Thymidine	1984
Biochemical interactions between N-(phosphonacetyl)-L-aspartate and 5-fluorouracil. Molecular pharmacology, 1982, Volume: 21, Issue:1 Topics: Animals; Aspartic Acid; Cells, Cultured; Deoxyuracil Nucleotides; Drug Interactions; Fluorodeoxyuridylate; Fluorouracil; Kinetics; Lacticaseibacillus casei; Mice; Organophosphorus Compounds; Phosphonoacetic Acid; Sarcoma 180; Thymidylate Synthase	1982
Phase I and clinical pharmacological evaluation of biochemical modulation of 5-fluorouracil with N-(phosphonacetyl)-L-aspartic acid. Cancer research, 1983, Volume: 43, Issue:5 Topics: Adult; Aged; Antimetabolites, Antineoplastic; Aspartic Acid; Blood Cell Count; Carcinoma; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Female; Fluorouracil; Gastrointestinal Diseases; Humans; Male; Middle Aged; Organophosphorus Compounds; Orotic Acid; Phosphonoacetic Acid; Pyrimidines; Sarcoma	1983
Phase I-phase II trial of N-phosphonacetyl-L-aspartic acid given by intravenous infusion and 5-fluorouracil given by bolus injection. Journal of the National Cancer Institute, 1982, Volume: 68, Issue:2 Topics: Adult; Aged; Antineoplastic Agents; Aspartic Acid; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Female; Fluorouracil; Humans; Infusions, Parenteral; Male; Melanoma; Middle Aged; Neoplasms; Organophosphorus Compounds; Ovarian Neoplasms; Pancreatic Neoplasms; Phosphonoacetic Acid; Sarcoma	1982
Pilot study of PALA and 5-FU in patients with advanced cancer. Cancer treatment reports, 1982, Volume: 66, Issue:1 Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Aspartic Acid; Cells, Cultured; Drug Evaluation; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Middle Aged; Organophosphorus Compounds; Phosphonoacetic Acid; RNA, Neoplasm	1982
Phase II trial of combination therapy with continuous-infusion PALA and bolus-injection 5-FU. Cancer treatment reports, 1982, Volume: 66, Issue:2 Topics: Adult; Aged; Aspartic Acid; Breast Neoplasms; Carcinoma; Colonic Neoplasms; Drug Evaluation; Drug Therapy, Combination; Fluorouracil; Humans; Infusions, Parenteral; Injections, Intravenous; Middle Aged; Organophosphorus Compounds; Pancreatic Neoplasms; Phosphonoacetic Acid; Sarcoma	1982
A phase I trial of combination therapy with continuous-infusion PALA and continuous-infusion 5-FU. Cancer chemotherapy and pharmacology, 1982, Volume: 8, Issue:3 Topics: Adult; Aged; Antineoplastic Agents; Aspartic Acid; Bone Marrow; Digestive System; Drug Evaluation; Drug Therapy, Combination; Female; Fluorouracil; Humans; Infusions, Parenteral; Male; Middle Aged; Neoplasms; Organophosphorus Compounds; Phosphonoacetic Acid	1982
Synergistic effect of 5-fluorouracil and N-(phosphonacetyl)-L-aspartate on cell growth and ribonucleic acid synthesis in human mammary carcinoma. Biochemical pharmacology, 1981, Aug-01, Volume: 30, Issue:15 Topics: Antineoplastic Agents; Aspartic Acid; Breast Neoplasms; Cell Division; Cell Line; Drug Synergism; Female; Fluorouracil; Humans; Organophosphorus Compounds; Phosphonoacetic Acid; Poly A; RNA, Neoplasm; Uridine Triphosphate	1981
Effect of modulators on 5-fluorouracil metabolite patterns in murine colon carcinoma determined by in vitro 19F nuclear magnetic resonance spectroscopy. Cancer research, 1994, Aug-15, Volume: 54, Issue:16 Topics: Animals; Aspartic Acid; Colonic Neoplasms; Female; Fluorine; Fluorouracil; Interferon-alpha; Leucovorin; Magnetic Resonance Spectroscopy; Methotrexate; Mice; Mice, Inbred C57BL; Phosphonoacetic Acid; Rats; Tumor Cells, Cultured	1994
5-Ethynyluracil (776C85): modulation of 5-fluorouracil efficacy and therapeutic index in rats bearing advanced colorectal carcinoma. Cancer research, 1994, Mar-15, Volume: 54, Issue:6 Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Drug Synergism; Female; Fluorouracil; Leucovorin; Neoplasm Transplantation; Phosphonoacetic Acid; Rats; Rats, Inbred F344; Uracil	1994
N-(phosphonacetyl)-L-aspartate synergistically enhances the cytotoxicity of 5-fluorouracil/interferon-alpha-2a against human colon cancer cell lines. Molecular pharmacology, 1993, Volume: 44, Issue:5 Topics: Antineoplastic Combined Chemotherapy Protocols; Aspartate Carbamoyltransferase; Aspartic Acid; Base Sequence; Cell Division; Cell Survival; Colonic Neoplasms; DNA, Neoplasm; Drug Synergism; Fluorouracil; Humans; Interferon alpha-2; Interferon-alpha; Molecular Sequence Data; Nucleotides; Oligodeoxyribonucleotides; Phosphonoacetic Acid; Recombinant Proteins; RNA, Neoplasm; Tumor Cells, Cultured	1993
Preservation of immune effector cell function following administration of a dose-intense 5-fluorouracil-chemotherapy regimen. Cancer immunology, immunotherapy : CII, 1993, Volume: 36, Issue:3 Topics: Adenocarcinoma; Antibody-Dependent Cell Cytotoxicity; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Dose-Response Relationship, Drug; Fluorouracil; Humans; Immunity, Cellular; Immunosuppressive Agents; Interleukin-2; Killer Cells, Natural; Leukocytes, Mononuclear; Lymphocytes; Monocytes; Phenotype; Phosphonoacetic Acid	1993
Uridine allows dose escalation of 5-fluorouracil when given with N-phosphonacetyl-L-aspartate, methotrexate, and leucovorin. Cancer, 1993, Mar-01, Volume: 71, Issue:5 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Diarrhea; Drug Synergism; Female; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Mouth Mucosa; Neoplasms; Phosphonoacetic Acid; Stomatitis; Uridine	1993
Enhanced antitumor activity of an adriamycin + 5-fluorouracil combination when preceded by biochemical modulation. Anti-cancer drugs, 1996, Volume: 7, Issue:1 Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Doxorubicin; Fluorouracil; Mammary Neoplasms, Animal; Mercaptopurine; Mice; Niacinamide; Phosphonoacetic Acid	1996
Inefficient growth arrest in response to dNTP starvation stimulates gene amplification through bridge-breakage-fusion cycles. Molecular biology of the cell, 1996, Volume: 7, Issue:3 Topics: Animals; Aspartate Carbamoyltransferase; Aspartic Acid; Cell Division; Cell Line; Cloning, Molecular; Cricetinae; DNA Damage; Fluorouracil; Gene Amplification; Growth Inhibitors; Humans; In Situ Hybridization, Fluorescence; Methotrexate; Phosphonoacetic Acid; Pyrimidine Nucleotides; Tumor Cells, Cultured	1996
Modulation of 5-fluorouracil with methotrexate and low-dose N-(phosphonacetyl)-L-aspartate (PALA) is inactive in advanced pancreatic carcinoma. Annals of oncology : official journal of the European Society for Medical Oncology, 1997, Volume: 8, Issue:9 Topics: Adenocarcinoma; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Female; Fluorouracil; Humans; Male; Methotrexate; Middle Aged; Pancreatic Neoplasms; Phosphonoacetic Acid	1997
Radiation enhancement by biochemical modulation and 5-fluorouracil. International journal of radiation oncology, biology, physics, 1997, Dec-01, Volume: 39, Issue:5 Topics: 6-Aminonicotinamide; Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cell Division; Combined Modality Therapy; Fluorouracil; Mammary Neoplasms, Animal; Methylthioinosine; Mice; Radiation-Sensitizing Agents; Radiotherapy Dosage; Time Factors	1997
A conserved aspartate of tRNA pseudouridine synthase is essential for activity and a probable nucleophilic catalyst. Biochemistry, 1998, Jan-06, Volume: 37, Issue:1 Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Catalysis; Cloning, Molecular; Conserved Sequence; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Escherichia coli; Fluorouracil; Genetic Vectors; Intramolecular Transferases; Molecular Sequence Data; Mutagenesis; Phosphorus Radioisotopes; RNA, Transfer, Asp; RNA, Transfer, Phe; Uracil	1998
Tumor, normal tissue, and plasma pharmacokinetic studies of fluorouracil biomodulation with N-phosphonacetyl-L-aspartate, folinic acid, and interferon alfa. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1999, Volume: 17, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Area Under Curve; Aspartic Acid; Colorectal Neoplasms; Drug Interactions; Female; Fluorouracil; Humans; Interferon-alpha; Leucovorin; Liver Neoplasms; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neoplasms; Phosphonoacetic Acid; Regional Blood Flow; Stomach Neoplasms; Tomography, Emission-Computed	1999
Ki-ras mutation type and the survival benefit from adjuvant chemotherapy in Dukes' C colorectal cancer. The Journal of pathology, 2001, Volume: 195, Issue:5 Topics: Adult; Aged; Antimetabolites, Antineoplastic; Aspartic Acid; Biomarkers, Tumor; Chemotherapy, Adjuvant; Colorectal Neoplasms; Female; Fluorouracil; Follow-Up Studies; Genes, ras; Humans; Male; Middle Aged; Mutation; Patient Selection; Prognosis; Regression Analysis; Retrospective Studies; Survival Rate; Treatment Outcome	2001
N-(phosphonacetyl)-L-aspartate and calcium leucovorin modulation of fluorouracil administered by constant rate and circadian pattern of infusion over 72 hours in metastatic gastrointestinal adenocarcinoma. Annals of oncology : official journal of the European Society for Medical Oncology, 2001, Volume: 12, Issue:11 Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartate Carbamoyltransferase; Aspartic Acid; Chronotherapy; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Phosphonoacetic Acid	2001
Thymidylate synthase protein expression in primary colorectal cancer: lack of correlation with outcome and response to fluorouracil in metastatic disease sites. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Mar-01, Volume: 21, Issue:5 Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Biomarkers, Tumor; Colorectal Neoplasms; Female; Fluorouracil; Humans; Immunoenzyme Techniques; Interferon alpha-2; Interferon-alpha; Leucovorin; Male; Middle Aged; Neoplasm Recurrence, Local; Phosphonoacetic Acid; Prognosis; Recombinant Proteins; Retrospective Studies; Survival Rate; Thymidylate Synthase; Treatment Outcome	2003
Multifocal inflammatory leukoencephalopathy: use of thallium-201 SPECT and proton MRS. Journal of Korean medical science, 2003, Volume: 18, Issue:4 Topics: Adjuvants, Immunologic; Antimetabolites, Antineoplastic; Aspartic Acid; Axons; Biopsy; Brain; Brain Neoplasms; Choline; Colorectal Neoplasms; Diagnosis, Differential; Fluorouracil; Humans; Lactic Acid; Leukoencephalopathy, Progressive Multifocal; Levamisole; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neoplasm Metastasis; Thallium Radioisotopes; Tomography, Emission-Computed, Single-Photon	2003
Treatment of intracranial rat glioma model with implant of radiosensitizer and biomodulator drug combined with external beam radiotherapy. International journal of radiation oncology, biology, physics, 2004, Feb-01, Volume: 58, Issue:2 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Brain Neoplasms; Bromodeoxyuridine; Cell Line, Tumor; Combined Modality Therapy; Drug Combinations; Drug Implants; Fluorouracil; Glioma; Immunologic Factors; Methotrexate; Phosphonoacetic Acid; Radiation-Sensitizing Agents; Rats	2004
Continued survival of more than ten years, without resection of metastatic disease, in patients with metastatic colorectal cancer treated with biomodulated fluorouracil: report of two cases. Diseases of the colon and rectum, 2006, Volume: 49, Issue:3 Topics: Acetates; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Female; Fluorouracil; Humans; Immunologic Factors; Leucovorin; Liver Neoplasms; Male; Methotrexate; Middle Aged; Phosphonoacetic Acid; Remission Induction; Uridine; Vitamin B Complex	2006
Dual targeting of glutaminase 1 and thymidylate synthase elicits death synergistically in NSCLC. Cell death & disease, 2016, 12-08, Volume: 7, Issue:12 Topics: A549 Cells; Adenosine Triphosphate; Animals; Aspartic Acid; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Death; Cell Proliferation; Cell Survival; Cytosol; Drug Synergism; Fluorouracil; Gene Knockdown Techniques; Glutamic Acid; Glutaminase; Glutamine; Lung Neoplasms; Malates; Mice, Inbred BALB C; Mice, Nude; Molecular Targeted Therapy; NAD; Oxidation-Reduction; Sulfides; Thiadiazoles; Thymidylate Synthase; Xenograft Model Antitumor Assays	2016
Long noncoding RNA OVAAL enhances nucleotide synthesis through pyruvate carboxylase to promote 5-fluorouracil resistance in gastric cancer. Cancer science, 2022, Volume: 113, Issue:9 Topics: Aspartic Acid; Cell Line, Tumor; Drug Resistance, Neoplasm; Fluorouracil; Humans; Nucleotides; Oxaloacetates; Pyruvate Carboxylase; RNA, Long Noncoding; Stomach Neoplasms	2022