fluorouracil and adenine

fluorouracil has been researched along with adenine in 64 studies

Research

Studies (64)

Timeframe	Studies, this research(%)	All Research%
pre-1990	27 (42.19)	18.7374
1990's	8 (12.50)	18.2507
2000's	7 (10.94)	29.6817
2010's	20 (31.25)	24.3611
2020's	2 (3.13)	2.80

Authors

Authors	Studies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Einhorn, R; Franki, N; Hays, RM; Levine, SD	1
Haber, JE; McCusker, JH	1
Chevallier, MR; Jund, R; Lacroute, F	1
Araujo, FG; Huskinson-Mark, J; Remington, JS	1
Eritja, R; Fazakerley, GV; Goodman, MF; Kaplan, BE; Sowers, LC	1
Kummer, D	1
Lipkin, M; Troncale, FJ	1
Mandel, HG; Reich, M	2
Blitzer, BL; Cushley, RJ; Lipsky, SR	1
Barner, HD; Cohen, SS; Stern, JL	1
Edlin, G; Neuhard, J	1
Giege, R; Weil, JH	1
Oriuchi, T	1
Katz, L; Rich, A; Tomita, K	1
Andrean, BA; De Kloet, SR; Mayo, VS	1
de Kloet, SR	1
Andrean, BA; De Kloet, SR; Hendricks, DV	1
Holliday, R	1
Burk, D; Woods, MW	1
Burchenal, JH; Butterbaugh, J; Dollinger, M; Giner-Sorolla, A; Stoll, D	1
Gallant, JA; Weisberg, RA	1
Hoshi, A; Kuretani, K; Yoshida, M	1
Azuma, A; Hanaoka, K; Kobayashi, T; Matsuda, A; Minakawa, N; Nakajima, Y; Nishizono, N; Sasaki, T; Suzuki, M; Tanaka, M	1
Domin, BA; Mahony, WB; Zimmerman, TP	1
Courtney, A; Cox, J; Meyer, W; Mues, G; Nemunaitis, J	1
Allan, PW; Bennett, LL; Gillespie, GY; Parker, WB; Rose, LM; Shaddix, SC; Speegle, HF	1
Beex, LV; De Abreu, RA; van Gennip, AH; van Kuilenburg, AB; Vreken, P	1
Berkowitz, I; Berry, D; Costanza, ME; Duggan, D; Henderson, IC; Kalra, J; Lyss, AP; Ratain, MJ; Shapiro, C; Wu, K	1
Berry, DA; Cirrincione, C; Costanza, ME; Frei, E; Henderson, IC; McIntyre, OR; Norton, L; Schilsky, RL; Weiss, RB; Winer, E; Wood, WC	1
Innocenti, F; Iyer, L; Ratain, MJ	1
Barsotti, C; Ipata, PL	1
Belinsky, MG; Chen, ZS; Guo, Y; Hopper-Borge, E; Kotova, E; Kruh, GD; Lee, K	1
KARNOFSKY, DA; SIMMEL, EB	1
KONO, M; OSAWA, S	1
KAPLAN, AS	1
KONO, M; OSAWA, S; OTAKA, E	1
CLARKE, CH	1
Boisdron-Celle, M; Fey, L; Gamelin, E; Lainé-Cessac, P; Morel, A	1
Faried, A; Hou, N; Kuwano, H; Li, J; Takeuchi, T; Tsutsumi, S	1
Lubin, A; Lubin, M	1
Bu, XX; Guo, XL; Hu, F; Li, R; Ma, NN; Song, JR; Sun, K; Tao, SF; Wei, LX; Wu, MC; Xiong, HY; Zhang, SS	1
Balzarini, J; Kiritsis, C; Komiotis, D; Manta, S; Tsoukala, E; Tzioumaki, N	1
Faried, A; Hou, N; Kuwano, H; Li, J; Tsutsumi, S	1
Höltje, HD; Höltje, M; Korting, HC; Murruzzu, C; Natek, M; Reissig, HU; Schäfer-Korting, M; Schwanke, A; Zdrazil, B; Zuhse, R	1
Winslet, MC; Yang, SY	1
Deng, WJ; Guo, XL; Hu, F; Li, D; Song, JR; Song, YJ; Sun, K; Wei, LX; Wu, MC; Xie, XQ; Zhang, SS; Zhao, QD	1
Dong, DL; Guo, WT; Liu, X; Sheng, Y; Sun, B; Xing, Y; Zhang, YH	1
Fan, C; Gao, J; Huang, Q; Lu, J; Mao, X; Shi, J; Simon, AJ; Wei, M; Zhu, C	1
Cheng, PC; Chiang, WF; Hong, WZ; Lee, SY; Lin, MH; Lin, PY; Liu, SY; Liu, YC; Yen, CY	1
Guillen, KP; Harrison, RG; Kurkjian, C; Restuccia, A	1
Chen, K; Duan, WM; Gong, FR; Gui, Q; Li, DM; Li, W; Lian, L; Liu, L; Shen, M; Tao, M; Wang, WJ; Wu, MY; Xu, MD; Zhu, J	1
Albrecht, P; Ford, JP; Kamerow, H; Mandetta, D; Thompson, JT; Vanden Heuvel, JP	1
Chen, L; Wang, J; Zhang, J; Zhang, L	1
Fang, JM; Guo, XL; Hu, F; Wang, H; Wei, LΧ; Xu, Q; Zhu, ZΖ	1
Chen, SH; Huang, KJ; Kuo, CH; Lee, YR; Lin, CY	1
Carlsson, M; Hu, GZ; Ronne, H	1
Liu, T; Yang, JW; Zhang, QH	1
Ji, Z; Yang, S; Zhang, J; Zhang, L	1
Asai, A; Doki, Y; Horie, N; Ishii, H; Kawamoto, K; Konno, M; Koseki, J; Mori, M; Obika, S; Tsunekuni, K	1
Guo, J; Huang, S; Huang, X; Li, J; Li, M; Lin, J; Qiao, Y; Yu, W; Zhang, P; Zhao, Y	1

Reviews

3 review(s) available for fluorouracil and adenine

Article	Year
The cell cycle and the development of pathology in the gastrointestinal tract. Pathobiology annual, 1972, Volume: 2 Topics: Adenine; Animals; Autoradiography; Cell Count; Cell Division; Colon; Digestive System; DNA; Flucytosine; Fluorouracil; Humans; Intestine, Small; Methotrexate; Pentosyltransferases; RNA; Stomach; Thymidine; Thymidine Kinase; Tritium	1972
Pharmacogenetics: a tool for individualizing antineoplastic therapy. Clinical pharmacokinetics, 2000, Volume: 39, Issue:5 Topics: Adenine; Antineoplastic Agents; Camptothecin; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Genotype; Glucuronosyltransferase; Humans; Imides; Irinotecan; Isoquinolines; Mercaptopurine; Methyltransferases; Naphthalimides; Organophosphonates; Oxidoreductases; Pharmacogenetics; Phenotype	2000
EFFECTS OF GROWTH-INHIBITING CHEMICALS ON THE SAND-DOLLAR EMBRYO, ECHINARACHNIUS PARMA. Progress in experimental tumor research, 1963, Volume: 3 Topics: Adenine; Animals; Azaguanine; Bromodeoxyuridine; Colchicine; Dinitrophenols; Echinodermata; Embryo, Mammalian; Embryo, Nonmammalian; Enzyme Inhibitors; Floxuridine; Fluorouracil; Growth; Idoxuridine; Mercaptopurine; Pharmacology; Pyrimidines; Sea Urchins	1963

Trials

2 trial(s) available for fluorouracil and adenine

Article	Year
Amonafide: An active agent in the treatment of previously untreated advanced breast cancer--a cancer and leukemia group B study (CALGB 8642). Clinical cancer research : an official journal of the American Association for Cancer Research, 1995, Volume: 1, Issue:7 Topics: Adenine; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Fluorouracil; Humans; Imides; Isoquinolines; Menopause; Middle Aged; Naphthalimides; Neoplasm Metastasis; Organophosphonates; Receptors, Estrogen	1995
Safety and efficacy of using a single agent or a phase II agent before instituting standard combination chemotherapy in previously untreated metastatic breast cancer patients: report of a randomized study--Cancer and Leukemia Group B 8642. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1999, Volume: 17, Issue:5 Topics: Adenine; Adult; Aged; Aminoglycosides; Analysis of Variance; Anti-Bacterial Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carboplatin; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Follow-Up Studies; Humans; Imides; Isoquinolines; Melphalan; Middle Aged; Naphthalimides; Neoplasm Staging; Organophosphonates; Prospective Studies; Survival Analysis; Trimetrexate	1999

Article

Year

Amonafide: An active agent in the treatment of previously untreated advanced breast cancer--a cancer and leukemia group B study (CALGB 8642).

Clinical cancer research : an official journal of the American Association for Cancer Research, 1995, Volume: 1, Issue:7

Topics: Adenine; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Fluorouracil; Humans; Imides; Isoquinolines; Menopause; Middle Aged; Naphthalimides; Neoplasm Metastasis; Organophosphonates; Receptors, Estrogen

1995

Safety and efficacy of using a single agent or a phase II agent before instituting standard combination chemotherapy in previously untreated metastatic breast cancer patients: report of a randomized study--Cancer and Leukemia Group B 8642.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1999, Volume: 17, Issue:5

Topics: Adenine; Adult; Aged; Aminoglycosides; Analysis of Variance; Anti-Bacterial Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carboplatin; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Follow-Up Studies; Humans; Imides; Isoquinolines; Melphalan; Middle Aged; Naphthalimides; Neoplasm Staging; Organophosphonates; Prospective Studies; Survival Analysis; Trimetrexate

1999

Other Studies

59 other study(ies) available for fluorouracil and adenine

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Vasopressin-stimulated movement of drugs and uric acid across the toad urinary bladder. Kidney international, 1976, Volume: 9, Issue:1 Topics: Adenine; Animals; Anti-Bacterial Agents; Anura; Butanols; Cell Membrane Permeability; Cyclic AMP; Cyclohexanones; Female; Fluorouracil; Glutethimide; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Phloretin; Stimulation, Chemical; Uric Acid; Urinary Bladder; Vasopressins	1976
Efficient sporulation of yeast in media buffered near pH6. Journal of bacteriology, 1977, Volume: 132, Issue:1 Topics: Acetates; Adenine; Canavanine; Culture Media; Fluorouracil; Fungal Proteins; Hydrogen-Ion Concentration; Lysine; Meiosis; Recombination, Genetic; Saccharomyces cerevisiae; Spores, Fungal	1977
Characterization of cytosine permeation in Saccharomyces cerevisiae. Journal of bacteriology, 1975, Volume: 122, Issue:2 Topics: Adenine; Aminohydrolases; Biological Transport, Active; Carbon Radioisotopes; Cytosine; Dinitrophenols; Drug Resistance, Microbial; Ethylmaleimide; Fluorouracil; Membrane Transport Proteins; Mutagens; Mutation; Nitrogen Mustard Compounds; Saccharomyces cerevisiae	1975
Evaluation of the effect of drugs on the cyst form of Toxoplasma gondii. The Journal of infectious diseases, 1991, Volume: 164, Issue:1 Topics: Adenine; Animals; Anti-Infective Agents; Atovaquone; Azithromycin; Brain; Clindamycin; Coccidiostats; Erythromycin; Fluorouracil; Mice; Mice, Inbred CBA; Naphthoquinones; Pyrimethamine; Sulfadiazine; Toxoplasma	1991
Structural and dynamic properties of a fluorouracil-adenine base pair in DNA studied by proton NMR. The Journal of biological chemistry, 1987, Nov-15, Volume: 262, Issue:32 Topics: Adenine; DNA; Fluorouracil; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation	1987
[Effects of cytostatics and x-rays on nucleic acid metabolism of solid, malignant tumors in vitro]. Zeitschrift fur Krebsforschung, 1970, Volume: 74, Issue:1 Topics: Adenine; Animals; Antineoplastic Agents; Carbon Isotopes; Dactinomycin; Depression, Chemical; DNA, Neoplasm; Estriol; Fluorouracil; Formates; Glycine; Hypoxanthines; In Vitro Techniques; Leucine; Mercaptopurine; Methotrexate; Methylprednisolone; Neoplasm Proteins; Neoplasms, Experimental; Nucleosides; Orotic Acid; Radiation Effects; RNA, Neoplasm; Testosterone; Thymidine; Triaziquone; Uracil; Uridine	1970
Dissociation of cellular functions in Bacillus cereus by 5-fluorouracil. Journal of bacteriology, 1966, Volume: 91, Issue:2 Topics: Adenine; Amino Acids; Bacillus cereus; Bacterial Proteins; Carbon Isotopes; Cell Wall; DNA, Bacterial; Fluorouracil; In Vitro Techniques; Penicillinase; RNA, Bacterial; Thymidine; Tritium; Uracil	1966
Anomeric configuration of nucleosides by application of the internal Nuclear Overhauser Effect. Biochemical and biophysical research communications, 1972, Sep-26, Volume: 48, Issue:6 Topics: Adenine; Chemical Phenomena; Chemistry; Deoxyribonucleosides; Fluorouracil; Furans; Guanine; Hypoxanthines; Magnetic Resonance Spectroscopy; Mathematics; Molecular Conformation; Nucleic Acid Conformation; Nucleosides; Spectrum Analysis; Stereoisomerism; Uracil	1972
The lethality of streptomycin and the stimulation of RNA synthesis in the absence of protein synthesis. Journal of molecular biology, 1966, Volume: 17, Issue:1 Topics: Adenine; Arginine; Bacterial Proteins; Carbon Isotopes; Chloramphenicol; Drug Resistance, Microbial; Escherichia coli; Fluorouracil; Guanine; Kanamycin; Neomycin; Phosphates; RNA, Bacterial; Streptomycin; Sulfur Isotopes; Thymine; Uracil	1966
Regulation of nucleoside triphosphate pools in Escherichia coli. Journal of molecular biology, 1967, Mar-14, Volume: 24, Issue:2 Topics: Adenine; Carbon Isotopes; Cytosine Nucleotides; Escherichia coli; Fluorouracil; Nucleotides; RNA, Bacterial; Uracil; Uridine	1967
[tRNA's from yeast having incorporated 5-fluorouracil arising from in vivo deamination of 5-fluorocytosine]. Bulletin de la Societe de chimie biologique, 1970, Mar-31, Volume: 52, Issue:2 Topics: Adenine; Amino Acids; Aminohydrolases; Chromatography, Paper; Cytosine; Deamination; Fluorine; Fluorouracil; Guanine; Mutation; RNA, Transfer; Saccharomyces; Spectrophotometry; Ultraviolet Rays; Uracil	1970
[On uptake of 5-FU, 6-MP and methotrexate by ehrlich ascites tumor cells in vitro]. Sapporo igaku zasshi. The Sapporo medical journal, 1970, Volume: 37, Issue:6 Topics: Adenine; Animals; Carcinoma, Ehrlich Tumor; Cell Membrane; Fluorouracil; In Vitro Techniques; Male; Mercaptopurine; Methotrexate; Mice; Sulfur Isotopes; Time Factors; Tritium; Uracil	1970
Crystal structure of the intermolecular complex 9-ethyladenine: 1-methyl-5-fluorouracil. Journal of molecular biology, 1967, Dec-28, Volume: 30, Issue:3 Topics: Adenine; Crystallography; Fluorouracil	1967
Effects of cycloheximide and 5-fluorouracil on the synthesis of ribonucleic acid in yeast. Biochimica et biophysica acta, 1968, Dec-17, Volume: 169, Issue:2 Topics: Adenine; Carbon Isotopes; Centrifugation, Density Gradient; Cycloheximide; Depression, Chemical; Fluorouracil; Methionine; Methylation; Molecular Weight; Nucleotides; Phenols; Phosphates; Phosphorus Isotopes; Ribosomes; RNA; Saccharomyces; Surface-Active Agents; Temperature	1968
Effects of 5-fluorouracil and 6-azauracil on the synthesis of ribonucleic acid and protein in Saccharomyces carlsbergensis. The Biochemical journal, 1968, Volume: 106, Issue:1 Topics: Adenine; Antimetabolites; Carbon Isotopes; Centrifugation, Density Gradient; Depression, Chemical; DNA; Enzyme Induction; Fluorouracil; Glucosidases; Lysine; Molecular Weight; Phosphorus Isotopes; Protein Biosynthesis; Protoplasts; Ribosomes; RNA; Saccharomyces; Time Factors; Triazines; Uracil	1968
Effects of cycloheximide and 5-fluorouracil on formation of low-molecular-weight ribonucleic acid in yeast. Journal of bacteriology, 1969, Volume: 97, Issue:2 Topics: Adenine; Carbon Isotopes; Chromatography; Chromatography, Gel; Cycloheximide; Fluorouracil; Leucine; Methionine; Nucleic Acid Denaturation; Nucleotides; Phosphates; Phosphorus Isotopes; Ribosomes; RNA; RNA, Transfer; Saccharomyces; Urea	1969
Errors in protein synthesis and clonal senescence in fungi. Nature, 1969, Mar-29, Volume: 221, Issue:5187 Topics: Adenine; Aging; Ascomycota; Culture Media; Fluorouracil; Genetic Code; Genetics, Microbial; Mutation; Neurospora; Phenotype; Phenylalanine; Protein Biosynthesis; RNA; Suppression, Genetic	1969
Antiglycolytic activities of 5-fluorouracil and related pyrimidines in mouse ascites carcinoma cells with special reference to inorganic phosphate and glucose. Oncology, 1969, Volume: 23, Issue:1 Topics: Adenine; Animals; Arsenic; Carcinoma, Ehrlich Tumor; Carcinoma, Krebs 2; Deoxyuridine; Fluorouracil; Fructose; Glucose; Glutamine; Glycolysis; In Vitro Techniques; Manometry; Mice; Nucleosides; Phenols; Phosphates; Pyrimidines; Pyruvates; Respiration; Succinates; Uracil; Uridine	1969
Studies of 6-N-hydroxylamino-9-beta-D-ribofuranosylpurine in mouse leukemia. Biochemical pharmacology, 1967, Volume: 16, Issue:3 Topics: Adenine; Animals; Body Weight; Cytarabine; Drug Antagonism; Drug Synergism; Fluorouracil; Guanine; Leukemia; Leukemia L1210; Mercaptopurine; Methotrexate; Mice; Nucleosides; Phosphotransferases; Purines; Vincristine	1967
Dual function of the lambda prophage repressor. Journal of molecular biology, 1967, May-14, Volume: 25, Issue:3 Topics: Adenine; Coliphages; DNA, Viral; Fluorouracil; Hot Temperature; Leucine; Molecular Biology; Mutation; Thymidine; Viral Proteins	1967
Inhibition of phosphoribosylation of 5-fluorouracil by purines. Nucleic acids symposium series, 1980, Issue:8 Topics: Adenine; Animals; Fluorouracil; Inosine; Kinetics; Leukemia L5178; Leukemia, Experimental; Mice; Pentosyltransferases; Phosphorylation; Purine-Nucleoside Phosphorylase	1980
Nucleosides and nucleotides. 122. 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine and its derivatives. A new class of nucleoside with a broad antitumor spectrum. Journal of medicinal chemistry, 1993, Dec-24, Volume: 36, Issue:26 Topics: Adenine; Animals; Antineoplastic Agents; Cytarabine; Female; Fluorouracil; Humans; Leukemia L1210; Lymphoma, Large B-Cell, Diffuse; Mice; Molecular Structure; Neoplasm Transplantation; Structure-Activity Relationship; Thymine; Tumor Cells, Cultured; Uracil	1993
Transport of 5-fluorouracil and uracil into human erythrocytes. Biochemical pharmacology, 1993, Aug-03, Volume: 46, Issue:3 Topics: Adenine; Biological Transport; Erythrocytes; Fluorouracil; Humans; Hypoxanthine; Hypoxanthines; Kinetics; Nucleic Acids; Nucleosides; Papaverine; Tritium; Uracil	1993
Irinotecan hydrochloride (CPT-11) resistance identified by K-ras mutation in patients with progressive colon cancer after treatment with 5-fluorouracil (5-FU). American journal of clinical oncology, 1997, Volume: 20, Issue:5 Topics: Adenine; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Codon; Colonic Neoplasms; Disease Progression; DNA, Neoplasm; Drug Resistance, Neoplasm; Exons; Female; Fluorouracil; Forecasting; Genes, ras; Guanine; Humans; Irinotecan; Male; Middle Aged; Mutation; Prognosis; Retreatment; Sequence Analysis, DNA; Survival Rate; Thymine; Treatment Failure	1997
Metabolism and metabolic actions of 6-methylpurine and 2-fluoroadenine in human cells. Biochemical pharmacology, 1998, May-15, Volume: 55, Issue:10 Topics: 3T3 Cells; Adenine; Animals; Cell Division; Cell Line; Cycloheximide; DNA; Fluorouracil; Humans; Mice; Nucleic Acid Synthesis Inhibitors; Protein Synthesis Inhibitors; Purines; RNA	1998
Severe 5-fluorouracil toxicity caused by reduced dihydropyrimidine dehydrogenase activity due to heterozygosity for a G-->A point mutation. Journal of inherited metabolic disease, 1998, Volume: 21, Issue:3 Topics: Adenine; Antimetabolites, Antineoplastic; Breast Neoplasms; Cells, Cultured; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Guanine; Heterozygote; Humans; Leukocytes, Mononuclear; Middle Aged; Oxidation-Reduction; Oxidoreductases; Point Mutation; Polymerase Chain Reaction; Transcription, Genetic	1998
Pathways for alpha-D-ribose utilization for nucleobase salvage and 5-fluorouracil activation in rat brain. Biochemical pharmacology, 2002, Jan-15, Volume: 63, Issue:2 Topics: Adenine; Animals; Antimetabolites; Brain; Fluorouracil; In Vitro Techniques; Male; Phosphoribosyl Pyrophosphate; Purine Nucleotides; Pyrimidine Nucleotides; Rats; Rats, Sprague-Dawley; Ribose; Uracil	2002
MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine. The Journal of biological chemistry, 2003, Aug-08, Volume: 278, Issue:32 Topics: Adenine; Adenosine Triphosphate; Animals; Antineoplastic Agents; Antiviral Agents; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Cell Membrane; Colforsin; Coloring Agents; Cyclic AMP; Cyclic GMP; DNA, Complementary; Dose-Response Relationship, Drug; Drug Resistance; Floxuridine; Fluorouracil; Genetic Vectors; Growth Inhibitors; Immunoblotting; Inhibitory Concentration 50; Insecta; Models, Biological; Nitrosamines; Nucleotides; Organophosphonates; Swine; Tetrazolium Salts; Thiazoles; Time Factors; Transfection; Zalcitabine	2003
URACIL: FAILURE TO RESTORE DNA SYNTHESIS WHILE RELIEVING 5-FLUOROURACIL-INDUCED INHIBITION. Science (New York, N.Y.), 1964, Jul-17, Volume: 145, Issue:3629 Topics: Adenine; Bacillus cereus; Carbon Isotopes; DNA; DNA, Bacterial; Fluorouracil; Formates; Guanine; Hypoxanthines; Metabolism; Pharmacology; Proteins; Research; RNA; Uracil	1964
INTERMEDIARY STEPS OF RIBOSOME FORMATION IN ESCHERICHIA COLI. Biochimica et biophysica acta, 1964, Jun-22, Volume: 87 Topics: Adenine; Chloramphenicol; Escherichia coli; Fluorouracil; Metabolism; Nucleosides; Physiological Phenomena; Research; Ribosomes; RNA; Tritium	1964
STUDIES ON THE REPLICATING POOL OF VIRAL DNA IN CELLS INFECTED WITH PSEUDORABIES VIRUS. Virology, 1964, Volume: 24 Topics: Adenine; Antiviral Agents; Carbon Isotopes; Cesium; Deoxyribonucleases; DNA; DNA, Viral; Fluorouracil; Herpesviridae; Herpesvirus 1, Suid; Nucleosides; Pharmacology; Research; Simplexvirus; Thymidine; Tissue Culture Techniques; Virus Cultivation	1964
CHANGES IN SEDIMENTATION PROPERTIES OF RIBOSOMAL RIBONUCLEIC ACIDS DURING THE COURSE OF RIBOSOME FORMATION IN ESCHERICHIA COLI. Biochimica et biophysica acta, 1964, Dec-16, Volume: 91 Topics: Adenine; Carbon Isotopes; Centrifugation; Chemical Phenomena; Chemistry, Physical; Chloramphenicol; Escherichia coli; Fluorouracil; Nucleosides; Pharmacology; Research; Ribosomes; RNA; RNA, Bacterial; RNA, Ribosomal; Tritium	1964
METHIONINE AS AN ANTIMUTAGEN IN SCHIZOSACCHAROMYCES POMBE. Journal of general microbiology, 1965, Volume: 39 Topics: Adenine; Antimutagenic Agents; Culture Media; Fluorouracil; Methionine; Mutagens; Mutation; Pharmacology; Purines; Radiation Effects; Research; Schizosaccharomyces; Ultraviolet Rays; Yeasts	1965
Identification of a novel mutation in the dihydropyrimidine dehydrogenase gene in a patient with a lethal outcome following 5-fluorouracil administration and the determination of its frequency in a population of 500 patients with colorectal carcinoma. Clinical biochemistry, 2007, Volume: 40, Issue:1-2 Topics: Adenine; Aged; Alleles; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); DNA Mutational Analysis; DNA, Complementary; Exons; Fatal Outcome; Female; Fluorouracil; Gene Frequency; Humans; Introns; Mutation; Pedigree; Polymorphism, Single Nucleotide; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Thymine; Uracil	2007
Inhibition of autophagy by 3-MA enhances the effect of 5-FU-induced apoptosis in colon cancer cells. Annals of surgical oncology, 2009, Volume: 16, Issue:3 Topics: Adenine; Antimetabolites, Antineoplastic; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Blotting, Western; Caspase 3; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cytochromes c; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Humans	2009
Selective killing of tumors deficient in methylthioadenosine phosphorylase: a novel strategy. PloS one, 2009, May-29, Volume: 4, Issue:5 Topics: Adenine; Cell Death; Cell Line; Coculture Techniques; Deoxyadenosines; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Neoplasms; Purine-Nucleoside Phosphorylase; Thioguanine	2009
Autophagic cell death induced by 5-FU in Bax or PUMA deficient human colon cancer cell. Cancer letters, 2010, Feb-01, Volume: 288, Issue:1 Topics: Adenine; Antimetabolites, Antineoplastic; Apoptosis Regulatory Proteins; Autophagy; bcl-2-Associated X Protein; Colonic Neoplasms; Dose-Response Relationship, Drug; Fluorouracil; HCT116 Cells; Humans; Intracellular Signaling Peptides and Proteins; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Signal Transduction; TOR Serine-Threonine Kinases	2010
Synthesis of 4,6-dideoxy-3-fluoro-2-keto-beta-D-glucopyranosyl analogues of 5-fluorouracil, N6-benzoyl adenine, uracil, thymine, N4-benzoyl cytosine and evaluation of their antitumor activities. Bioorganic chemistry, 2010, Volume: 38, Issue:2 Topics: Adenine; Animals; Antineoplastic Agents; Cell Line, Tumor; Cytosine; Drug Screening Assays, Antitumor; Fluorouracil; HeLa Cells; Humans; Mice; Nucleosides; Stereoisomerism; Thymine; Uracil	2010
Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model. European journal of cancer (Oxford, England : 1990), 2010, Volume: 46, Issue:10 Topics: Adenine; AMP-Activated Protein Kinase Kinases; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Autophagy-Related Protein 7; Cell Line, Tumor; Colonic Neoplasms; Drug Synergism; Enzyme Inhibitors; Fluorouracil; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Protein Kinases; Random Allocation; RNA, Small Interfering; Transplantation, Heterologous; Tumor Suppressor Protein p53; Ubiquitin-Activating Enzymes	2010
Antitumor effects of guanosine-analog phosphonates identified by molecular modelling. International journal of pharmaceutics, 2010, Sep-15, Volume: 397, Issue:1-2 Topics: Adenine; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Fluorouracil; HT29 Cells; Humans; Keratinocytes; Keratosis, Actinic; Models, Molecular; Molecular Dynamics Simulation; Organophosphonates	2010
Dual role of autophagy in colon cancer cell survival. Annals of surgical oncology, 2011, Volume: 18 Suppl 3 Topics: Adenine; Antimetabolites, Antineoplastic; Apoptosis; Autophagy; Colonic Neoplasms; Fluorouracil; Humans	2011
Targeting autophagy potentiates chemotherapy-induced apoptosis and proliferation inhibition in hepatocarcinoma cells. Cancer letters, 2012, Jul-28, Volume: 320, Issue:2 Topics: Adenine; Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cisplatin; Fluorouracil; Humans; Liver Neoplasms; Male; Membrane Potential, Mitochondrial; Membrane Proteins; Mice; Mice, Nude; Neoplasm Transplantation	2012
3-Methyladenine induces cell death and its interaction with chemotherapeutic drugs is independent of autophagy. Biochemical and biophysical research communications, 2013, Mar-01, Volume: 432, Issue:1 Topics: Adenine; Antineoplastic Agents; Autophagy; Cisplatin; Drug Agonism; Drug Synergism; Fluorouracil; HeLa Cells; Humans; MCF-7 Cells; Microtubule-Associated Proteins; Tamoxifen	2013
Real time in vitro regulation of DNA methylation using a 5-fluorouracil conjugated DNA-based stimuli-responsive platform. ACS applied materials & interfaces, 2013, Apr-10, Volume: 5, Issue:7 Topics: Adenine; Antineoplastic Agents, Alkylating; Carbocyanines; DNA; DNA Methylation; DNA Restriction Enzymes; DNA, Single-Stranded; Fluorouracil; HeLa Cells; Humans; Microscopy, Confocal; Site-Specific DNA-Methyltransferase (Adenine-Specific); Spectrometry, Fluorescence	2013
Long-term stimulation of areca nut components results in increased chemoresistance through elevated autophagic activity. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2014, Volume: 43, Issue:2 Topics: Actins; Adenine; Antimetabolites, Antineoplastic; Antineoplastic Agents; Areca; Autophagy; Autophagy-Related Proteins; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Chloroquine; Cisplatin; Cysteine Endopeptidases; Drug Resistance, Neoplasm; Fluorouracil; Glucose; Humans; Indicators and Reagents; Jurkat Cells; Microtubule-Associated Proteins; Mouth Neoplasms; Plant Extracts; Tetrazolium Salts; Time Factors	2014
Annexin V-Directed Enzyme Prodrug Therapy Plus Docetaxel for the Targeted Treatment of Pancreatic Cancer. Pancreas, 2015, Volume: 44, Issue:6 Topics: Adenine; Adenocarcinoma; Annexin A5; Antineoplastic Combined Chemotherapy Protocols; Carbon-Sulfur Lyases; Cell Death; Cell Line, Tumor; Cytosine Deaminase; Docetaxel; Dose-Response Relationship, Drug; Enzymes; Flucytosine; Fluorouracil; Humans; Methanol; Molecular Targeted Therapy; Organoselenium Compounds; Pancreatic Neoplasms; Prodrugs; Purine-Nucleoside Phosphorylase; Recombinant Fusion Proteins; Selenomethionine; Taxoids; Tubulin Modulators; Vidarabine	2015
Participation of autophagy in the cytotoxicity against breast cancer cells by cisplatin. Oncology reports, 2015, Volume: 34, Issue:1 Topics: Adenine; Antineoplastic Agents; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cisplatin; Cyclophosphamide; Docetaxel; Epirubicin; Female; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Methotrexate; Taxoids	2015
Differential nucleobase protection against 5-fluorouracil toxicity for squamous and columnar cells: implication for tissue function and oncogenesis. Investigational new drugs, 2015, Volume: 33, Issue:5 Topics: Adenine; Carcinogenesis; Cell Line, Tumor; DNA Replication; Epithelial Cells; Esophagus; Fluorouracil; Gastric Mucosa; Gene Expression; Humans; Nucleobase Transport Proteins; Protective Agents; Pyrimidines; RNA, Messenger; Uracil	2015
Autophagy in human skin squamous cell carcinoma: Inhibition by 3-MA enhances the effect of 5-FU-induced chemotherapy sensitivity. Oncology reports, 2015, Volume: 34, Issue:6 Topics: Adenine; Apoptosis; Autophagy; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Synergism; Fluorouracil; Humans; Inhibitor of Apoptosis Proteins; Microtubule-Associated Proteins; Neoplasm Invasiveness; Proto-Oncogene Proteins c-bcl-2; Skin Neoplasms; Survivin	2015
Inhibition of autophagy in hepatocarcinoma cells promotes chemotherapeutic agent-induced apoptosis during nutrient deprivation. Oncology reports, 2018, Volume: 39, Issue:2 Topics: Adenine; Antineoplastic Agents; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Carcinoma, Hepatocellular; Cell Culture Techniques; Cell Line, Tumor; Cell Survival; Cisplatin; Fluorouracil; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Membrane Potential, Mitochondrial; Mitochondria	2018
Honokiol inhibits in vitro and in vivo growth of oral squamous cell carcinoma through induction of apoptosis, cell cycle arrest and autophagy. Journal of cellular and molecular medicine, 2018, Volume: 22, Issue:3 Topics: Adenine; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Biphenyl Compounds; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Fluorouracil; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Lignans; Macrolides; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mouth Neoplasms; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tumor Burden; Xenograft Model Antitumor Assays	2018
Gene dosage effects in yeast support broader roles for the LOG1, HAM1 and DUT1 genes in detoxification of nucleotide analogues. PloS one, 2018, Volume: 13, Issue:5 Topics: Adenine; Antimetabolites; Cloning, Molecular; Drug Resistance, Fungal; Fluorouracil; Fungal Proteins; Gene Dosage; Gene Expression Regulation, Fungal; Gene Knockout Techniques; Genes, Fungal; Inactivation, Metabolic; Purines; Pyrimidines; Recombinant Proteins; Saccharomyces cerevisiae Proteins; Substrate Specificity	2018
Autophagy facilitates anticancer effect of 5-fluorouracil in HCT-116 cells. Journal of cancer research and therapeutics, 2018, Volume: 14, Issue:Supplement Topics: Adenine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Beclin-1; Cell Proliferation; Colorectal Neoplasms; Drug Screening Assays, Antitumor; Drug Synergism; Fluorouracil; HCT116 Cells; Humans; Microtubule-Associated Proteins; RNA, Small Interfering; Sirolimus	2018
Photodynamic therapy enhances skin cancer chemotherapy effects through autophagy regulation. Photodiagnosis and photodynamic therapy, 2019, Volume: 28 Topics: Adenine; Aminolevulinic Acid; Autophagy; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Fluorouracil; Humans; Melanoma; Photochemotherapy; Photosensitizing Agents; Skin Neoplasms	2019
Theoretical analyses and experimental validation of the effects caused by the fluorinated substituent modification of DNA. Scientific reports, 2020, 01-24, Volume: 10, Issue:1 Topics: Adenine; Antimetabolites, Antineoplastic; Base Pairing; DNA; DNA Damage; Fluorouracil; Hydrogen Bonding; Molecular Dynamics Simulation; Molecular Structure; Nucleic Acid Conformation; Quantum Theory; Thermodynamics; Trifluridine	2020
Functional Phosphoproteomics in Cancer Chemoresistance Using CRISPR-Mediated Base Editors. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022, Volume: 9, Issue:30 Topics: Adenine; Amino Acids; Clustered Regularly Interspaced Short Palindromic Repeats; Colorectal Neoplasms; Cytosine; Drug Resistance, Neoplasm; Fluorouracil; Humans; p21-Activated Kinases; Protein Kinases	2022