fluorouracil has been researched along with adenine in 64 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 27 (42.19) | 18.7374 |
1990's | 8 (12.50) | 18.2507 |
2000's | 7 (10.94) | 29.6817 |
2010's | 20 (31.25) | 24.3611 |
2020's | 2 (3.13) | 2.80 |
Authors | Studies |
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Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
Einhorn, R; Franki, N; Hays, RM; Levine, SD | 1 |
Haber, JE; McCusker, JH | 1 |
Chevallier, MR; Jund, R; Lacroute, F | 1 |
Araujo, FG; Huskinson-Mark, J; Remington, JS | 1 |
Eritja, R; Fazakerley, GV; Goodman, MF; Kaplan, BE; Sowers, LC | 1 |
Kummer, D | 1 |
Lipkin, M; Troncale, FJ | 1 |
Mandel, HG; Reich, M | 2 |
Blitzer, BL; Cushley, RJ; Lipsky, SR | 1 |
Barner, HD; Cohen, SS; Stern, JL | 1 |
Edlin, G; Neuhard, J | 1 |
Giege, R; Weil, JH | 1 |
Oriuchi, T | 1 |
Katz, L; Rich, A; Tomita, K | 1 |
Andrean, BA; De Kloet, SR; Mayo, VS | 1 |
de Kloet, SR | 1 |
Andrean, BA; De Kloet, SR; Hendricks, DV | 1 |
Holliday, R | 1 |
Burk, D; Woods, MW | 1 |
Burchenal, JH; Butterbaugh, J; Dollinger, M; Giner-Sorolla, A; Stoll, D | 1 |
Gallant, JA; Weisberg, RA | 1 |
Hoshi, A; Kuretani, K; Yoshida, M | 1 |
Azuma, A; Hanaoka, K; Kobayashi, T; Matsuda, A; Minakawa, N; Nakajima, Y; Nishizono, N; Sasaki, T; Suzuki, M; Tanaka, M | 1 |
Domin, BA; Mahony, WB; Zimmerman, TP | 1 |
Courtney, A; Cox, J; Meyer, W; Mues, G; Nemunaitis, J | 1 |
Allan, PW; Bennett, LL; Gillespie, GY; Parker, WB; Rose, LM; Shaddix, SC; Speegle, HF | 1 |
Beex, LV; De Abreu, RA; van Gennip, AH; van Kuilenburg, AB; Vreken, P | 1 |
Berkowitz, I; Berry, D; Costanza, ME; Duggan, D; Henderson, IC; Kalra, J; Lyss, AP; Ratain, MJ; Shapiro, C; Wu, K | 1 |
Berry, DA; Cirrincione, C; Costanza, ME; Frei, E; Henderson, IC; McIntyre, OR; Norton, L; Schilsky, RL; Weiss, RB; Winer, E; Wood, WC | 1 |
Innocenti, F; Iyer, L; Ratain, MJ | 1 |
Barsotti, C; Ipata, PL | 1 |
Belinsky, MG; Chen, ZS; Guo, Y; Hopper-Borge, E; Kotova, E; Kruh, GD; Lee, K | 1 |
KARNOFSKY, DA; SIMMEL, EB | 1 |
KONO, M; OSAWA, S | 1 |
KAPLAN, AS | 1 |
KONO, M; OSAWA, S; OTAKA, E | 1 |
CLARKE, CH | 1 |
Boisdron-Celle, M; Fey, L; Gamelin, E; Lainé-Cessac, P; Morel, A | 1 |
Faried, A; Hou, N; Kuwano, H; Li, J; Takeuchi, T; Tsutsumi, S | 1 |
Lubin, A; Lubin, M | 1 |
Bu, XX; Guo, XL; Hu, F; Li, R; Ma, NN; Song, JR; Sun, K; Tao, SF; Wei, LX; Wu, MC; Xiong, HY; Zhang, SS | 1 |
Balzarini, J; Kiritsis, C; Komiotis, D; Manta, S; Tsoukala, E; Tzioumaki, N | 1 |
Faried, A; Hou, N; Kuwano, H; Li, J; Tsutsumi, S | 1 |
Höltje, HD; Höltje, M; Korting, HC; Murruzzu, C; Natek, M; Reissig, HU; Schäfer-Korting, M; Schwanke, A; Zdrazil, B; Zuhse, R | 1 |
Winslet, MC; Yang, SY | 1 |
Deng, WJ; Guo, XL; Hu, F; Li, D; Song, JR; Song, YJ; Sun, K; Wei, LX; Wu, MC; Xie, XQ; Zhang, SS; Zhao, QD | 1 |
Dong, DL; Guo, WT; Liu, X; Sheng, Y; Sun, B; Xing, Y; Zhang, YH | 1 |
Fan, C; Gao, J; Huang, Q; Lu, J; Mao, X; Shi, J; Simon, AJ; Wei, M; Zhu, C | 1 |
Cheng, PC; Chiang, WF; Hong, WZ; Lee, SY; Lin, MH; Lin, PY; Liu, SY; Liu, YC; Yen, CY | 1 |
Guillen, KP; Harrison, RG; Kurkjian, C; Restuccia, A | 1 |
Chen, K; Duan, WM; Gong, FR; Gui, Q; Li, DM; Li, W; Lian, L; Liu, L; Shen, M; Tao, M; Wang, WJ; Wu, MY; Xu, MD; Zhu, J | 1 |
Albrecht, P; Ford, JP; Kamerow, H; Mandetta, D; Thompson, JT; Vanden Heuvel, JP | 1 |
Chen, L; Wang, J; Zhang, J; Zhang, L | 1 |
Fang, JM; Guo, XL; Hu, F; Wang, H; Wei, LΧ; Xu, Q; Zhu, ZΖ | 1 |
Chen, SH; Huang, KJ; Kuo, CH; Lee, YR; Lin, CY | 1 |
Carlsson, M; Hu, GZ; Ronne, H | 1 |
Liu, T; Yang, JW; Zhang, QH | 1 |
Ji, Z; Yang, S; Zhang, J; Zhang, L | 1 |
Asai, A; Doki, Y; Horie, N; Ishii, H; Kawamoto, K; Konno, M; Koseki, J; Mori, M; Obika, S; Tsunekuni, K | 1 |
Guo, J; Huang, S; Huang, X; Li, J; Li, M; Lin, J; Qiao, Y; Yu, W; Zhang, P; Zhao, Y | 1 |
3 review(s) available for fluorouracil and adenine
Article | Year |
---|---|
The cell cycle and the development of pathology in the gastrointestinal tract.
Topics: Adenine; Animals; Autoradiography; Cell Count; Cell Division; Colon; Digestive System; DNA; Flucytosine; Fluorouracil; Humans; Intestine, Small; Methotrexate; Pentosyltransferases; RNA; Stomach; Thymidine; Thymidine Kinase; Tritium | 1972 |
Pharmacogenetics: a tool for individualizing antineoplastic therapy.
Topics: Adenine; Antineoplastic Agents; Camptothecin; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Genotype; Glucuronosyltransferase; Humans; Imides; Irinotecan; Isoquinolines; Mercaptopurine; Methyltransferases; Naphthalimides; Organophosphonates; Oxidoreductases; Pharmacogenetics; Phenotype | 2000 |
EFFECTS OF GROWTH-INHIBITING CHEMICALS ON THE SAND-DOLLAR EMBRYO, ECHINARACHNIUS PARMA.
Topics: Adenine; Animals; Azaguanine; Bromodeoxyuridine; Colchicine; Dinitrophenols; Echinodermata; Embryo, Mammalian; Embryo, Nonmammalian; Enzyme Inhibitors; Floxuridine; Fluorouracil; Growth; Idoxuridine; Mercaptopurine; Pharmacology; Pyrimidines; Sea Urchins | 1963 |
2 trial(s) available for fluorouracil and adenine
Article | Year |
---|---|
Amonafide: An active agent in the treatment of previously untreated advanced breast cancer--a cancer and leukemia group B study (CALGB 8642).
Topics: Adenine; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Fluorouracil; Humans; Imides; Isoquinolines; Menopause; Middle Aged; Naphthalimides; Neoplasm Metastasis; Organophosphonates; Receptors, Estrogen | 1995 |
Safety and efficacy of using a single agent or a phase II agent before instituting standard combination chemotherapy in previously untreated metastatic breast cancer patients: report of a randomized study--Cancer and Leukemia Group B 8642.
Topics: Adenine; Adult; Aged; Aminoglycosides; Analysis of Variance; Anti-Bacterial Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carboplatin; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Follow-Up Studies; Humans; Imides; Isoquinolines; Melphalan; Middle Aged; Naphthalimides; Neoplasm Staging; Organophosphonates; Prospective Studies; Survival Analysis; Trimetrexate | 1999 |
59 other study(ies) available for fluorouracil and adenine
Article | Year |
---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Vasopressin-stimulated movement of drugs and uric acid across the toad urinary bladder.
Topics: Adenine; Animals; Anti-Bacterial Agents; Anura; Butanols; Cell Membrane Permeability; Cyclic AMP; Cyclohexanones; Female; Fluorouracil; Glutethimide; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Phloretin; Stimulation, Chemical; Uric Acid; Urinary Bladder; Vasopressins | 1976 |
Efficient sporulation of yeast in media buffered near pH6.
Topics: Acetates; Adenine; Canavanine; Culture Media; Fluorouracil; Fungal Proteins; Hydrogen-Ion Concentration; Lysine; Meiosis; Recombination, Genetic; Saccharomyces cerevisiae; Spores, Fungal | 1977 |
Characterization of cytosine permeation in Saccharomyces cerevisiae.
Topics: Adenine; Aminohydrolases; Biological Transport, Active; Carbon Radioisotopes; Cytosine; Dinitrophenols; Drug Resistance, Microbial; Ethylmaleimide; Fluorouracil; Membrane Transport Proteins; Mutagens; Mutation; Nitrogen Mustard Compounds; Saccharomyces cerevisiae | 1975 |
Evaluation of the effect of drugs on the cyst form of Toxoplasma gondii.
Topics: Adenine; Animals; Anti-Infective Agents; Atovaquone; Azithromycin; Brain; Clindamycin; Coccidiostats; Erythromycin; Fluorouracil; Mice; Mice, Inbred CBA; Naphthoquinones; Pyrimethamine; Sulfadiazine; Toxoplasma | 1991 |
Structural and dynamic properties of a fluorouracil-adenine base pair in DNA studied by proton NMR.
Topics: Adenine; DNA; Fluorouracil; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation | 1987 |
[Effects of cytostatics and x-rays on nucleic acid metabolism of solid, malignant tumors in vitro].
Topics: Adenine; Animals; Antineoplastic Agents; Carbon Isotopes; Dactinomycin; Depression, Chemical; DNA, Neoplasm; Estriol; Fluorouracil; Formates; Glycine; Hypoxanthines; In Vitro Techniques; Leucine; Mercaptopurine; Methotrexate; Methylprednisolone; Neoplasm Proteins; Neoplasms, Experimental; Nucleosides; Orotic Acid; Radiation Effects; RNA, Neoplasm; Testosterone; Thymidine; Triaziquone; Uracil; Uridine | 1970 |
Dissociation of cellular functions in Bacillus cereus by 5-fluorouracil.
Topics: Adenine; Amino Acids; Bacillus cereus; Bacterial Proteins; Carbon Isotopes; Cell Wall; DNA, Bacterial; Fluorouracil; In Vitro Techniques; Penicillinase; RNA, Bacterial; Thymidine; Tritium; Uracil | 1966 |
Anomeric configuration of nucleosides by application of the internal Nuclear Overhauser Effect.
Topics: Adenine; Chemical Phenomena; Chemistry; Deoxyribonucleosides; Fluorouracil; Furans; Guanine; Hypoxanthines; Magnetic Resonance Spectroscopy; Mathematics; Molecular Conformation; Nucleic Acid Conformation; Nucleosides; Spectrum Analysis; Stereoisomerism; Uracil | 1972 |
The lethality of streptomycin and the stimulation of RNA synthesis in the absence of protein synthesis.
Topics: Adenine; Arginine; Bacterial Proteins; Carbon Isotopes; Chloramphenicol; Drug Resistance, Microbial; Escherichia coli; Fluorouracil; Guanine; Kanamycin; Neomycin; Phosphates; RNA, Bacterial; Streptomycin; Sulfur Isotopes; Thymine; Uracil | 1966 |
Regulation of nucleoside triphosphate pools in Escherichia coli.
Topics: Adenine; Carbon Isotopes; Cytosine Nucleotides; Escherichia coli; Fluorouracil; Nucleotides; RNA, Bacterial; Uracil; Uridine | 1967 |
[tRNA's from yeast having incorporated 5-fluorouracil arising from in vivo deamination of 5-fluorocytosine].
Topics: Adenine; Amino Acids; Aminohydrolases; Chromatography, Paper; Cytosine; Deamination; Fluorine; Fluorouracil; Guanine; Mutation; RNA, Transfer; Saccharomyces; Spectrophotometry; Ultraviolet Rays; Uracil | 1970 |
[On uptake of 5-FU, 6-MP and methotrexate by ehrlich ascites tumor cells in vitro].
Topics: Adenine; Animals; Carcinoma, Ehrlich Tumor; Cell Membrane; Fluorouracil; In Vitro Techniques; Male; Mercaptopurine; Methotrexate; Mice; Sulfur Isotopes; Time Factors; Tritium; Uracil | 1970 |
Crystal structure of the intermolecular complex 9-ethyladenine: 1-methyl-5-fluorouracil.
Topics: Adenine; Crystallography; Fluorouracil | 1967 |
Effects of cycloheximide and 5-fluorouracil on the synthesis of ribonucleic acid in yeast.
Topics: Adenine; Carbon Isotopes; Centrifugation, Density Gradient; Cycloheximide; Depression, Chemical; Fluorouracil; Methionine; Methylation; Molecular Weight; Nucleotides; Phenols; Phosphates; Phosphorus Isotopes; Ribosomes; RNA; Saccharomyces; Surface-Active Agents; Temperature | 1968 |
Effects of 5-fluorouracil and 6-azauracil on the synthesis of ribonucleic acid and protein in Saccharomyces carlsbergensis.
Topics: Adenine; Antimetabolites; Carbon Isotopes; Centrifugation, Density Gradient; Depression, Chemical; DNA; Enzyme Induction; Fluorouracil; Glucosidases; Lysine; Molecular Weight; Phosphorus Isotopes; Protein Biosynthesis; Protoplasts; Ribosomes; RNA; Saccharomyces; Time Factors; Triazines; Uracil | 1968 |
Effects of cycloheximide and 5-fluorouracil on formation of low-molecular-weight ribonucleic acid in yeast.
Topics: Adenine; Carbon Isotopes; Chromatography; Chromatography, Gel; Cycloheximide; Fluorouracil; Leucine; Methionine; Nucleic Acid Denaturation; Nucleotides; Phosphates; Phosphorus Isotopes; Ribosomes; RNA; RNA, Transfer; Saccharomyces; Urea | 1969 |
Errors in protein synthesis and clonal senescence in fungi.
Topics: Adenine; Aging; Ascomycota; Culture Media; Fluorouracil; Genetic Code; Genetics, Microbial; Mutation; Neurospora; Phenotype; Phenylalanine; Protein Biosynthesis; RNA; Suppression, Genetic | 1969 |
Antiglycolytic activities of 5-fluorouracil and related pyrimidines in mouse ascites carcinoma cells with special reference to inorganic phosphate and glucose.
Topics: Adenine; Animals; Arsenic; Carcinoma, Ehrlich Tumor; Carcinoma, Krebs 2; Deoxyuridine; Fluorouracil; Fructose; Glucose; Glutamine; Glycolysis; In Vitro Techniques; Manometry; Mice; Nucleosides; Phenols; Phosphates; Pyrimidines; Pyruvates; Respiration; Succinates; Uracil; Uridine | 1969 |
Studies of 6-N-hydroxylamino-9-beta-D-ribofuranosylpurine in mouse leukemia.
Topics: Adenine; Animals; Body Weight; Cytarabine; Drug Antagonism; Drug Synergism; Fluorouracil; Guanine; Leukemia; Leukemia L1210; Mercaptopurine; Methotrexate; Mice; Nucleosides; Phosphotransferases; Purines; Vincristine | 1967 |
Dual function of the lambda prophage repressor.
Topics: Adenine; Coliphages; DNA, Viral; Fluorouracil; Hot Temperature; Leucine; Molecular Biology; Mutation; Thymidine; Viral Proteins | 1967 |
Inhibition of phosphoribosylation of 5-fluorouracil by purines.
Topics: Adenine; Animals; Fluorouracil; Inosine; Kinetics; Leukemia L5178; Leukemia, Experimental; Mice; Pentosyltransferases; Phosphorylation; Purine-Nucleoside Phosphorylase | 1980 |
Nucleosides and nucleotides. 122. 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine and its derivatives. A new class of nucleoside with a broad antitumor spectrum.
Topics: Adenine; Animals; Antineoplastic Agents; Cytarabine; Female; Fluorouracil; Humans; Leukemia L1210; Lymphoma, Large B-Cell, Diffuse; Mice; Molecular Structure; Neoplasm Transplantation; Structure-Activity Relationship; Thymine; Tumor Cells, Cultured; Uracil | 1993 |
Transport of 5-fluorouracil and uracil into human erythrocytes.
Topics: Adenine; Biological Transport; Erythrocytes; Fluorouracil; Humans; Hypoxanthine; Hypoxanthines; Kinetics; Nucleic Acids; Nucleosides; Papaverine; Tritium; Uracil | 1993 |
Irinotecan hydrochloride (CPT-11) resistance identified by K-ras mutation in patients with progressive colon cancer after treatment with 5-fluorouracil (5-FU).
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Codon; Colonic Neoplasms; Disease Progression; DNA, Neoplasm; Drug Resistance, Neoplasm; Exons; Female; Fluorouracil; Forecasting; Genes, ras; Guanine; Humans; Irinotecan; Male; Middle Aged; Mutation; Prognosis; Retreatment; Sequence Analysis, DNA; Survival Rate; Thymine; Treatment Failure | 1997 |
Metabolism and metabolic actions of 6-methylpurine and 2-fluoroadenine in human cells.
Topics: 3T3 Cells; Adenine; Animals; Cell Division; Cell Line; Cycloheximide; DNA; Fluorouracil; Humans; Mice; Nucleic Acid Synthesis Inhibitors; Protein Synthesis Inhibitors; Purines; RNA | 1998 |
Severe 5-fluorouracil toxicity caused by reduced dihydropyrimidine dehydrogenase activity due to heterozygosity for a G-->A point mutation.
Topics: Adenine; Antimetabolites, Antineoplastic; Breast Neoplasms; Cells, Cultured; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Guanine; Heterozygote; Humans; Leukocytes, Mononuclear; Middle Aged; Oxidation-Reduction; Oxidoreductases; Point Mutation; Polymerase Chain Reaction; Transcription, Genetic | 1998 |
Pathways for alpha-D-ribose utilization for nucleobase salvage and 5-fluorouracil activation in rat brain.
Topics: Adenine; Animals; Antimetabolites; Brain; Fluorouracil; In Vitro Techniques; Male; Phosphoribosyl Pyrophosphate; Purine Nucleotides; Pyrimidine Nucleotides; Rats; Rats, Sprague-Dawley; Ribose; Uracil | 2002 |
MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine.
Topics: Adenine; Adenosine Triphosphate; Animals; Antineoplastic Agents; Antiviral Agents; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Cell Membrane; Colforsin; Coloring Agents; Cyclic AMP; Cyclic GMP; DNA, Complementary; Dose-Response Relationship, Drug; Drug Resistance; Floxuridine; Fluorouracil; Genetic Vectors; Growth Inhibitors; Immunoblotting; Inhibitory Concentration 50; Insecta; Models, Biological; Nitrosamines; Nucleotides; Organophosphonates; Swine; Tetrazolium Salts; Thiazoles; Time Factors; Transfection; Zalcitabine | 2003 |
URACIL: FAILURE TO RESTORE DNA SYNTHESIS WHILE RELIEVING 5-FLUOROURACIL-INDUCED INHIBITION.
Topics: Adenine; Bacillus cereus; Carbon Isotopes; DNA; DNA, Bacterial; Fluorouracil; Formates; Guanine; Hypoxanthines; Metabolism; Pharmacology; Proteins; Research; RNA; Uracil | 1964 |
INTERMEDIARY STEPS OF RIBOSOME FORMATION IN ESCHERICHIA COLI.
Topics: Adenine; Chloramphenicol; Escherichia coli; Fluorouracil; Metabolism; Nucleosides; Physiological Phenomena; Research; Ribosomes; RNA; Tritium | 1964 |
STUDIES ON THE REPLICATING POOL OF VIRAL DNA IN CELLS INFECTED WITH PSEUDORABIES VIRUS.
Topics: Adenine; Antiviral Agents; Carbon Isotopes; Cesium; Deoxyribonucleases; DNA; DNA, Viral; Fluorouracil; Herpesviridae; Herpesvirus 1, Suid; Nucleosides; Pharmacology; Research; Simplexvirus; Thymidine; Tissue Culture Techniques; Virus Cultivation | 1964 |
CHANGES IN SEDIMENTATION PROPERTIES OF RIBOSOMAL RIBONUCLEIC ACIDS DURING THE COURSE OF RIBOSOME FORMATION IN ESCHERICHIA COLI.
Topics: Adenine; Carbon Isotopes; Centrifugation; Chemical Phenomena; Chemistry, Physical; Chloramphenicol; Escherichia coli; Fluorouracil; Nucleosides; Pharmacology; Research; Ribosomes; RNA; RNA, Bacterial; RNA, Ribosomal; Tritium | 1964 |
METHIONINE AS AN ANTIMUTAGEN IN SCHIZOSACCHAROMYCES POMBE.
Topics: Adenine; Antimutagenic Agents; Culture Media; Fluorouracil; Methionine; Mutagens; Mutation; Pharmacology; Purines; Radiation Effects; Research; Schizosaccharomyces; Ultraviolet Rays; Yeasts | 1965 |
Identification of a novel mutation in the dihydropyrimidine dehydrogenase gene in a patient with a lethal outcome following 5-fluorouracil administration and the determination of its frequency in a population of 500 patients with colorectal carcinoma.
Topics: Adenine; Aged; Alleles; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); DNA Mutational Analysis; DNA, Complementary; Exons; Fatal Outcome; Female; Fluorouracil; Gene Frequency; Humans; Introns; Mutation; Pedigree; Polymorphism, Single Nucleotide; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Thymine; Uracil | 2007 |
Inhibition of autophagy by 3-MA enhances the effect of 5-FU-induced apoptosis in colon cancer cells.
Topics: Adenine; Antimetabolites, Antineoplastic; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Blotting, Western; Caspase 3; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cytochromes c; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Humans | 2009 |
Selective killing of tumors deficient in methylthioadenosine phosphorylase: a novel strategy.
Topics: Adenine; Cell Death; Cell Line; Coculture Techniques; Deoxyadenosines; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Neoplasms; Purine-Nucleoside Phosphorylase; Thioguanine | 2009 |
Autophagic cell death induced by 5-FU in Bax or PUMA deficient human colon cancer cell.
Topics: Adenine; Antimetabolites, Antineoplastic; Apoptosis Regulatory Proteins; Autophagy; bcl-2-Associated X Protein; Colonic Neoplasms; Dose-Response Relationship, Drug; Fluorouracil; HCT116 Cells; Humans; Intracellular Signaling Peptides and Proteins; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Signal Transduction; TOR Serine-Threonine Kinases | 2010 |
Synthesis of 4,6-dideoxy-3-fluoro-2-keto-beta-D-glucopyranosyl analogues of 5-fluorouracil, N6-benzoyl adenine, uracil, thymine, N4-benzoyl cytosine and evaluation of their antitumor activities.
Topics: Adenine; Animals; Antineoplastic Agents; Cell Line, Tumor; Cytosine; Drug Screening Assays, Antitumor; Fluorouracil; HeLa Cells; Humans; Mice; Nucleosides; Stereoisomerism; Thymine; Uracil | 2010 |
Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model.
Topics: Adenine; AMP-Activated Protein Kinase Kinases; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Autophagy-Related Protein 7; Cell Line, Tumor; Colonic Neoplasms; Drug Synergism; Enzyme Inhibitors; Fluorouracil; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Protein Kinases; Random Allocation; RNA, Small Interfering; Transplantation, Heterologous; Tumor Suppressor Protein p53; Ubiquitin-Activating Enzymes | 2010 |
Antitumor effects of guanosine-analog phosphonates identified by molecular modelling.
Topics: Adenine; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Fluorouracil; HT29 Cells; Humans; Keratinocytes; Keratosis, Actinic; Models, Molecular; Molecular Dynamics Simulation; Organophosphonates | 2010 |
Dual role of autophagy in colon cancer cell survival.
Topics: Adenine; Antimetabolites, Antineoplastic; Apoptosis; Autophagy; Colonic Neoplasms; Fluorouracil; Humans | 2011 |
Targeting autophagy potentiates chemotherapy-induced apoptosis and proliferation inhibition in hepatocarcinoma cells.
Topics: Adenine; Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cisplatin; Fluorouracil; Humans; Liver Neoplasms; Male; Membrane Potential, Mitochondrial; Membrane Proteins; Mice; Mice, Nude; Neoplasm Transplantation | 2012 |
3-Methyladenine induces cell death and its interaction with chemotherapeutic drugs is independent of autophagy.
Topics: Adenine; Antineoplastic Agents; Autophagy; Cisplatin; Drug Agonism; Drug Synergism; Fluorouracil; HeLa Cells; Humans; MCF-7 Cells; Microtubule-Associated Proteins; Tamoxifen | 2013 |
Real time in vitro regulation of DNA methylation using a 5-fluorouracil conjugated DNA-based stimuli-responsive platform.
Topics: Adenine; Antineoplastic Agents, Alkylating; Carbocyanines; DNA; DNA Methylation; DNA Restriction Enzymes; DNA, Single-Stranded; Fluorouracil; HeLa Cells; Humans; Microscopy, Confocal; Site-Specific DNA-Methyltransferase (Adenine-Specific); Spectrometry, Fluorescence | 2013 |
Long-term stimulation of areca nut components results in increased chemoresistance through elevated autophagic activity.
Topics: Actins; Adenine; Antimetabolites, Antineoplastic; Antineoplastic Agents; Areca; Autophagy; Autophagy-Related Proteins; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Chloroquine; Cisplatin; Cysteine Endopeptidases; Drug Resistance, Neoplasm; Fluorouracil; Glucose; Humans; Indicators and Reagents; Jurkat Cells; Microtubule-Associated Proteins; Mouth Neoplasms; Plant Extracts; Tetrazolium Salts; Time Factors | 2014 |
Annexin V-Directed Enzyme Prodrug Therapy Plus Docetaxel for the Targeted Treatment of Pancreatic Cancer.
Topics: Adenine; Adenocarcinoma; Annexin A5; Antineoplastic Combined Chemotherapy Protocols; Carbon-Sulfur Lyases; Cell Death; Cell Line, Tumor; Cytosine Deaminase; Docetaxel; Dose-Response Relationship, Drug; Enzymes; Flucytosine; Fluorouracil; Humans; Methanol; Molecular Targeted Therapy; Organoselenium Compounds; Pancreatic Neoplasms; Prodrugs; Purine-Nucleoside Phosphorylase; Recombinant Fusion Proteins; Selenomethionine; Taxoids; Tubulin Modulators; Vidarabine | 2015 |
Participation of autophagy in the cytotoxicity against breast cancer cells by cisplatin.
Topics: Adenine; Antineoplastic Agents; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cisplatin; Cyclophosphamide; Docetaxel; Epirubicin; Female; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Methotrexate; Taxoids | 2015 |
Differential nucleobase protection against 5-fluorouracil toxicity for squamous and columnar cells: implication for tissue function and oncogenesis.
Topics: Adenine; Carcinogenesis; Cell Line, Tumor; DNA Replication; Epithelial Cells; Esophagus; Fluorouracil; Gastric Mucosa; Gene Expression; Humans; Nucleobase Transport Proteins; Protective Agents; Pyrimidines; RNA, Messenger; Uracil | 2015 |
Autophagy in human skin squamous cell carcinoma: Inhibition by 3-MA enhances the effect of 5-FU-induced chemotherapy sensitivity.
Topics: Adenine; Apoptosis; Autophagy; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Synergism; Fluorouracil; Humans; Inhibitor of Apoptosis Proteins; Microtubule-Associated Proteins; Neoplasm Invasiveness; Proto-Oncogene Proteins c-bcl-2; Skin Neoplasms; Survivin | 2015 |
Inhibition of autophagy in hepatocarcinoma cells promotes chemotherapeutic agent-induced apoptosis during nutrient deprivation.
Topics: Adenine; Antineoplastic Agents; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Carcinoma, Hepatocellular; Cell Culture Techniques; Cell Line, Tumor; Cell Survival; Cisplatin; Fluorouracil; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Membrane Potential, Mitochondrial; Mitochondria | 2018 |
Honokiol inhibits in vitro and in vivo growth of oral squamous cell carcinoma through induction of apoptosis, cell cycle arrest and autophagy.
Topics: Adenine; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Biphenyl Compounds; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Fluorouracil; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Lignans; Macrolides; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mouth Neoplasms; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tumor Burden; Xenograft Model Antitumor Assays | 2018 |
Gene dosage effects in yeast support broader roles for the LOG1, HAM1 and DUT1 genes in detoxification of nucleotide analogues.
Topics: Adenine; Antimetabolites; Cloning, Molecular; Drug Resistance, Fungal; Fluorouracil; Fungal Proteins; Gene Dosage; Gene Expression Regulation, Fungal; Gene Knockout Techniques; Genes, Fungal; Inactivation, Metabolic; Purines; Pyrimidines; Recombinant Proteins; Saccharomyces cerevisiae Proteins; Substrate Specificity | 2018 |
Autophagy facilitates anticancer effect of 5-fluorouracil in HCT-116 cells.
Topics: Adenine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Beclin-1; Cell Proliferation; Colorectal Neoplasms; Drug Screening Assays, Antitumor; Drug Synergism; Fluorouracil; HCT116 Cells; Humans; Microtubule-Associated Proteins; RNA, Small Interfering; Sirolimus | 2018 |
Photodynamic therapy enhances skin cancer chemotherapy effects through autophagy regulation.
Topics: Adenine; Aminolevulinic Acid; Autophagy; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Fluorouracil; Humans; Melanoma; Photochemotherapy; Photosensitizing Agents; Skin Neoplasms | 2019 |
Theoretical analyses and experimental validation of the effects caused by the fluorinated substituent modification of DNA.
Topics: Adenine; Antimetabolites, Antineoplastic; Base Pairing; DNA; DNA Damage; Fluorouracil; Hydrogen Bonding; Molecular Dynamics Simulation; Molecular Structure; Nucleic Acid Conformation; Quantum Theory; Thermodynamics; Trifluridine | 2020 |
Functional Phosphoproteomics in Cancer Chemoresistance Using CRISPR-Mediated Base Editors.
Topics: Adenine; Amino Acids; Clustered Regularly Interspaced Short Palindromic Repeats; Colorectal Neoplasms; Cytosine; Drug Resistance, Neoplasm; Fluorouracil; Humans; p21-Activated Kinases; Protein Kinases | 2022 |