fluorouracil has been researched along with acetylcysteine in 25 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.00) | 18.7374 |
| 1990's | 3 (12.00) | 18.2507 |
| 2000's | 9 (36.00) | 29.6817 |
| 2010's | 11 (44.00) | 24.3611 |
| 2020's | 1 (4.00) | 2.80 |
| Authors | Studies |
|---|---|
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| He, D; Hu, M; Li, K; Li, Y; Wang, B; Yang, K; Zheng, L | 1 |
| Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
| Kline, I | 1 |
| Beauchamp, RD; Brockman, JA; Chinery, R; Coffey, RJ; Peeler, MO; Shyr, Y | 1 |
| Kobayashi, Y; Miyamoto, M; Morimoto, Y; Sugibayashi, K | 1 |
| Choi, YH; Henkart, PA; Hwang, SG; Jang, JS; Lee, J; Lee, SJ; Maki, M; Nguyen, PM; Takano, E; Trepel, JB; Wu, ML | 1 |
| Adeyemo, D; Imtiaz, F; Lowdell, M; Toffa, S; Wickremasinghe, RG; Winslet, M | 1 |
| Arai, F; Gomei, Y; Hosokawa, K; Ito, K; Iwasaki, H; Miyamoto, K; Nakamura, Y; Shima, H; Suda, T; Yoshihara, H | 1 |
| Eliashar, R; Hirshoren, N | 1 |
| Du, N; Hao, YX; Pei, XT; Sun, JZ; Zhou, JM | 1 |
| Grebhardt, S; Haefeli, WE; Theile, D; Weiss, J | 1 |
| Hatsuno, M; Hida, A; Miyake, S; Numazawa, S; Sugihara, K; Tomiyama, H; Yamamoto, M; Yoshida, T | 1 |
| Bhat, MK; Chaube, B; Pandey, V | 1 |
| Hu, X; Lei, L; Liang, J; Liu, L; Sun, J; Wu, D; Zou, X | 1 |
| Bossis, G; Boulanger, M; Hyun, JW; Kang, HK; Kang, KA; Kim, SB; Paolillo, R; Piao, MJ; Ryu, YS; Shilnikova, K; Yi, JM; Yoon, SY | 1 |
| Amadio, B; Baldi, A; Condello, M; Delfine, S; Mastrodonato, F; Meschini, S; Occhionero, G; Pellegrini, E; Spugnini, EP; Vincenzi, B | 1 |
2 review(s) available for fluorouracil and acetylcysteine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Wound-healing modulation in upper airway stenosis-Myths and facts.
Topics: Acetylcysteine; Aminopropionitrile; Animals; Antimetabolites; Colchicine; Fluorouracil; Humans; Hyperbaric Oxygenation; Laryngostenosis; Mitomycin; Nucleic Acid Synthesis Inhibitors; Piperidines; Protein Synthesis Inhibitors; Quinazolinones; Secondary Prevention; Wound Healing | 2009 |
23 other study(ies) available for fluorouracil and acetylcysteine
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Target ROS to induce apoptosis and cell cycle arrest by 5,7-dimethoxy-1,4-naphthoquinone derivative.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; K562 Cells; Molecular Structure; Naphthoquinones; Reactive Oxygen Species; Structure-Activity Relationship | 2018 |
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
Potentially useful combinations of chemotherapy detected in mouse tumor systems.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Azauridine; Bleomycin; Camptothecin; Cyclic P-Oxides; Cyclophosphamide; Cytarabine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Ethylamines; Fluorouracil; Imidazoles; Leukemia L1210; Lung Neoplasms; Methotrexate; Mice; Neoplasms, Experimental; Oxazines; Piperazines; Procarbazine; Propane; Triazenes | 1974 |
Antioxidants enhance the cytotoxicity of chemotherapeutic agents in colorectal cancer: a p53-independent induction of p21WAF1/CIP1 via C/EBPbeta.
Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; CCAAT-Enhancer-Binding Proteins; Colorectal Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA-Binding Proteins; Doxorubicin; Drug Interactions; Enzyme Inhibitors; Fluorouracil; Humans; Nuclear Proteins; Pyrrolidines; Thiocarbamates; Transcription Factors; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Vitamin E | 1997 |
Enhancing effect of N-acetyl-l-cysteine or 2-mercaptoethanol on the in vitro permeation of 5-fluorouracil or tolnaftate through the human nail plate.
Topics: Absorption; Acetylcysteine; Adult; Antifungal Agents; Antimetabolites, Antineoplastic; Chemical Phenomena; Chemistry, Physical; Fluorouracil; Humans; In Vitro Techniques; Male; Mercaptoethanol; Nails; Permeability; Solubility; Solvents; Tolnaftate | 1998 |
Posttranslational regulation of the retinoblastoma gene family member p107 by calpain protease.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Bucladesine; Calpain; Cyclin B; Cyclin B1; Cysteine Proteinase Inhibitors; Dipeptides; Fluorouracil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ketones; Leupeptins; Lovastatin; Nuclear Proteins; Protein Processing, Post-Translational; Retinoblastoma Protein; Retinoblastoma-Like Protein p107; Tumor Cells, Cultured | 1999 |
Antioxidants enhance the susceptibility of colon carcinoma cells to 5-fluorouracil by augmenting the induction of the bax protein.
Topics: Acetylcysteine; Antimetabolites, Antineoplastic; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Colonic Neoplasms; Drug Interactions; Flow Cytometry; Fluorouracil; Free Radical Scavengers; Humans; Oxidation-Reduction; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Time Factors; Tumor Cells, Cultured; Vitamin E | 2001 |
Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction.
Topics: Acetylcysteine; Animals; Bone Marrow Cells; Cadherins; Cell Count; Cells, Cultured; Enzyme Inhibitors; Flow Cytometry; Fluorouracil; Free Radical Scavengers; Gene Expression; Hematopoietic Stem Cells; Imidazoles; Immunohistochemistry; Mice; Mice, Inbred C57BL; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyridines; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors | 2007 |
[Effects of fluorouracil-induced Flt3 Ligand gene expression transcriptional regulated by Egr-1 promoter sequences].
Topics: Acetylcysteine; Antigens, CD34; Antimetabolites, Antineoplastic; Blotting, Western; Cell Line; Cell Proliferation; Cell Survival; Culture Media, Conditioned; Early Growth Response Protein 1; Fetal Blood; Flow Cytometry; Fluorouracil; Free Radical Scavengers; Gene Expression; Green Fluorescent Proteins; Hematopoietic Stem Cells; Humans; Membrane Proteins; Microscopy, Fluorescence; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Transfection | 2009 |
Involvement of drug transporters in the synergistic action of FOLFOX combination chemotherapy.
Topics: Acetylcysteine; Adenosine Triphosphatases; Animals; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cation Transport Proteins; Cell Line; Cell Line, Tumor; Cell Proliferation; Dogs; Drug Resistance, Neoplasm; Drug Synergism; Fluorouracil; Glutathione; Humans; Leucovorin; Mice; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organoplatinum Compounds; Oxaliplatin; RNA, Messenger | 2009 |
Possible involvement of oxidative stress in 5-fluorouracil-mediated myelosuppression in mice.
Topics: Acetylcysteine; Animals; Bone Marrow; Enzyme Induction; Fluorouracil; Glutathione; Heme Oxygenase-1; Immunosuppressive Agents; Male; Mice; Mice, Inbred C57BL; Oxidative Stress | 2011 |
Hyperglycemia regulates MDR-1, drug accumulation and ROS levels causing increased toxicity of carboplatin and 5-fluorouracil in MCF-7 cells.
Topics: Acetylcysteine; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Carboplatin; Cell Line, Tumor; Female; Fluorouracil; Glucose; Humans; Hyperglycemia; Inhibitory Concentration 50; NF-kappa B; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Verapamil | 2011 |
Allicin sensitizes hepatocellular cancer cells to anti-tumor activity of 5-fluorouracil through ROS-mediated mitochondrial pathway.
Topics: Acetylcysteine; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Cell Line, Tumor; Cell Survival; Disulfides; Drug Synergism; Fluorouracil; Humans; Liver Neoplasms; Membrane Potential, Mitochondrial; Mice; Mitochondria; Poly (ADP-Ribose) Polymerase-1; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Sulfinic Acids; Xenograft Model Antitumor Assays | 2016 |
DUOX2-mediated production of reactive oxygen species induces epithelial mesenchymal transition in 5-fluorouracil resistant human colon cancer cells.
Topics: Acetylcysteine; Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Neoplasm; Dual Oxidases; Epithelial-Mesenchymal Transition; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Mixed Function Oxygenases; Neoplasm Proteins; Promoter Regions, Genetic; Proto-Oncogene Proteins; Reactive Oxygen Species | 2018 |
Anticancer activity of "Trigno M", extract of Prunus spinosa drupes, against in vitro 3D and in vivo colon cancer models.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Apoptosis; Cell Movement; Cell Proliferation; Colonic Neoplasms; Female; Fluorouracil; HCT116 Cells; Humans; Mice, SCID; Models, Biological; Plant Extracts; Prunus; Spheroids, Cellular; Tumor Stem Cell Assay; Xenograft Model Antitumor Assays | 2019 |