fluorouracil has been researched along with 5-fluorouridine 5'-triphosphate in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (39.13) | 18.7374 |
| 1990's | 7 (30.43) | 18.2507 |
| 2000's | 3 (13.04) | 29.6817 |
| 2010's | 2 (8.70) | 24.3611 |
| 2020's | 2 (8.70) | 2.80 |
| Authors | Studies |
|---|---|
| Griffiths, JR; Maxwell, RJ; McSheehy, PM | 1 |
| Laurensse, EJ; Peters, GJ; Pinedo, HM; van Groeningen, CJ | 1 |
| Harada, M; Koga, K; Miura, I; Nishitani, H; Shirahama, T | 1 |
| Klubes, P; Parker, WB | 1 |
| Griffiths, JR; McSheehy, PM; Prior, MJ | 1 |
| Fischer, PH; Grem, JL | 1 |
| Chouini, N; Lepargneur, JP; Malet-Martino, MC; Martino, R; Michel, G; Vialaneix, JP | 1 |
| Fox, RM; Piper, AA | 1 |
| Danenberg, PV; Heidelberger, C; Moran, RG | 1 |
| Bernheim, JL; De Dobbeleer, GB; Roobol, C | 1 |
| Lankelma, J; Laurensse, E; Leyva, A; Peters, GJ; Pinedo, HM | 1 |
| Ardalan, B; Cooney, DA; Glazer, RI; Jayaram, HN; Kensler, TW; Macdonald, JS; Van Pham, T | 1 |
| Hidaka, K; Hisatsugu, T; Kohno, K; Komiyama, S; Kuwano, M; Sato, S | 1 |
| Ghoshal, K; Jacob, ST | 1 |
| Aherne, GW; Allegra, CJ; Geoffroy, F; Grem, JL; Hardcastle, A; Johnston, PG; Ren, Q; Van Groeningen, CJ | 1 |
| Hull, WE; Lutz, NW | 1 |
| Diasio, R; Ezzeldin, H; Fourie, J; Lee, A | 1 |
| Hosoda, S; Kamano, T; Miyakawa, A; Okuzawa, A; Sakamoto, K; Sakamoto, S; Yurimoto, S | 1 |
| Agudo, R; Arias, A; Domingo, E; EscarmÃs, C; Jorge, A; Marina, A; Pariente, N; Perales, C | 1 |
| Beijnen, JH; Derissen, EJ; Hillebrand, MJ; Rosing, H; Schellens, JH | 1 |
| Beijnen, JH; Derissen, EJ; Huitema, AD; Jacobs, BA; Rosing, H; Schellens, JH | 1 |
| Hussain, S | 1 |
| Beijnen, JH; de Vries, N; Huitema, ADR; Jacobs, BAW; Marchetti, S; Nuijen, B; Pluim, D; Roosendaal, J; Rosing, H; Schellens, JHM; van Werkhoven, E | 1 |
2 review(s) available for fluorouracil and 5-fluorouridine 5'-triphosphate
| Article | Year |
|---|---|
Fluorinated pyrimidines and their nucleosides.
Topics: Animals; Enzyme Activation; Fluorouracil; Humans; Neoplasms; Pyrimidines; RNA; Thymidylate Synthase; Transcription, Genetic; Uracil Nucleotides; Uridine Triphosphate | 1983 |
Dihydropyrimidine dehydrogenase deficiency: impact of pharmacogenetics on 5-fluorouracil therapy.
Topics: Antidotes; Antimetabolites, Antineoplastic; Biotransformation; Deoxyuracil Nucleotides; Diarrhea; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); DNA Mutational Analysis; Drug Eruptions; Fever; Floxuridine; Fluorouracil; Humans; Inactivation, Metabolic; Mass Screening; Mucositis; Mutation; Prodrugs; Pyrimidine Nucleosides; Thymidylate Synthase; Uridine Triphosphate | 2004 |
1 trial(s) available for fluorouracil and 5-fluorouridine 5'-triphosphate
| Article | Year |
|---|---|
Phase I pharmacological study of continuous chronomodulated capecitabine treatment.
Topics: Adult; Aged; Antineoplastic Agents; Capecitabine; Circadian Rhythm; Dihydrouracil Dehydrogenase (NADP); Drug Chronotherapy; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Thymidylate Synthase; Uridine Triphosphate | 2020 |
20 other study(ies) available for fluorouracil and 5-fluorouridine 5'-triphosphate
| Article | Year |
|---|---|
Detection of differential sensitivity to 5-fluorouracil in Ehrlich ascites tumour cells by 19F NMR spectroscopy.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Carcinoma, Ehrlich Tumor; Cell Extracts; Chromatography, High Pressure Liquid; Fluorodeoxyuridylate; Fluorouracil; Magnetic Resonance Spectroscopy; Phosphorus; Protons; Tumor Cells, Cultured; Uracil Nucleotides; Uridine Diphosphate Glucose; Uridine Triphosphate | 1991 |
A comparison of 5-fluorouracil metabolism in human colorectal cancer and colon mucosa.
Topics: Adenosine Triphosphate; Aged; Aged, 80 and over; Colon; Colonic Neoplasms; Fluorodeoxyuridylate; Fluorouracil; Humans; Intestinal Mucosa; Middle Aged; Orotate Phosphoribosyltransferase; Pentosyltransferases; Phosphoribosyl Pyrophosphate; Pyrimidine Phosphorylases; Rectal Neoplasms; Ribosemonophosphates; Uracil Nucleotides; Uridine Triphosphate | 1991 |
[In-vivo 19F-MRS study of 5-fluorouracil (5-FU) metabolism on tumors].
Topics: Animals; beta-Alanine; Fluorine; Fluorouracil; Liver; Liver Neoplasms, Experimental; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Inbred F344; Rats, Inbred Strains; Sarcoma, Yoshida; Tissue Distribution; Uridine Triphosphate | 1991 |
Enhancement by uridine of the anabolism of 5-fluorouracil in mouse T-lymphoma (S-49) cells.
Topics: Animals; Cell Survival; Cells, Cultured; DNA; Fluorouracil; Lymphoma; Mice; Phosphoribosyl Pyrophosphate; Protein Biosynthesis; Pyrimidines; RNA; T-Lymphocytes; Tritium; Uridine; Uridine Triphosphate | 1985 |
Prediction of 5-fluorouracil cytotoxicity towards the Walker carcinosarcoma using peak integrals of fluoronucleotides measured by MRS in vivo.
Topics: Animals; Carcinoma 256, Walker; Deoxyuracil Nucleotides; Female; Fluorodeoxyuridylate; Fluorouracil; Magnetic Resonance Spectroscopy; Rats; Rats, Inbred Strains; Uridine Triphosphate | 1989 |
Alteration of fluorouracil metabolism in human colon cancer cells by dipyridamole with a selective increase in fluorodeoxyuridine monophosphate levels.
Topics: Cells, Cultured; Colonic Neoplasms; Deoxyuracil Nucleotides; Deoxyuridine; Dipyridamole; DNA; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Ribonucleotides; Time Factors; Uridine Triphosphate | 1986 |
Noninvasive and quantitative 19F nuclear magnetic resonance study of flucytosine metabolism in Candida strains.
Topics: Candida; Culture Media; Drug Resistance, Microbial; Flucytosine; Fluorouracil; Magnetic Resonance Spectroscopy; Pentosyltransferases; Uridine Triphosphate | 1986 |
Biochemical basis for the differential sensitivity of human T- and B-lymphocyte lines to 5-fluorouracil.
Topics: B-Lymphocytes; Biotransformation; Cell Line; Fluorodeoxyuridylate; Fluorouracil; Humans; Orotate Phosphoribosyltransferase; Orotic Acid; RNA; T-Lymphocytes; Thymidine Phosphorylase; Uridine; Uridine Phosphorylase; Uridine Triphosphate | 1982 |
5-fluorouracil and 5-fluoro-2'-deoxyuridine follow different metabolic pathways in the induction of cell lethality in L1210 leukaemia.
Topics: Animals; Cell Survival; Cells, Cultured; DNA, Neoplasm; Floxuridine; Fluorouracil; Isomerism; Leukemia L1210; Thymidine Monophosphate; Uridine Triphosphate | 1984 |
Separation of several 5-fluorouracil metabolites in various melanoma cell lines. Evidence for the synthesis of 5-fluorouracil-nucleotide sugars.
Topics: Animals; Aspartic Acid; Cell Line; Cells, Cultured; Chromatography; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Fluorouracil; Humans; Melanoma; Mice; Phosphonoacetic Acid; RNA, Neoplasm; Uracil Nucleotides; Uridine; Uridine Triphosphate | 1984 |
Synergistic effect of 5-fluorouracil and N-(phosphonacetyl)-L-aspartate on cell growth and ribonucleic acid synthesis in human mammary carcinoma.
Topics: Antineoplastic Agents; Aspartic Acid; Breast Neoplasms; Cell Division; Cell Line; Drug Synergism; Female; Fluorouracil; Humans; Organophosphorus Compounds; Phosphonoacetic Acid; Poly A; RNA, Neoplasm; Uridine Triphosphate | 1981 |
Differentially potentiating effects by dipyridamole on cytotoxicity of 5-fluorouracil against three human maxillary cancer cell lines derived from a single tumor.
Topics: Cell Survival; Dipyridamole; Drug Synergism; Fluorodeoxyuridylate; Fluorouracil; Humans; Maxillary Neoplasms; Tumor Cells, Cultured; Uridine Triphosphate | 1993 |
Specific inhibition of pre-ribosomal RNA processing in extracts from the lymphosarcoma cells treated with 5-fluorouracil.
Topics: Animals; Base Sequence; Cell Division; Cell Nucleus; DNA, Ribosomal; Fluorouracil; Lymphoma, Non-Hodgkin; Mice; Molecular Sequence Data; RNA Precursors; RNA, Neoplasm; RNA, Ribosomal; Trans-Activators; Transcription, Genetic; Tumor Cells, Cultured; Uracil Nucleotides; Uridine Triphosphate | 1994 |
Determinants of cytotoxicity with prolonged exposure to fluorouracil in human colon cancer cells.
Topics: Cell Division; Cell Survival; Colonic Neoplasms; Deoxyribonucleotides; Deoxyuracil Nucleotides; DNA Damage; DNA, Neoplasm; Dose-Response Relationship, Drug; Fluorodeoxyuridylate; Fluorouracil; Gene Expression Regulation, Enzymologic; Humans; Leucovorin; Thymidylate Synthase; Tumor Cells, Cultured; Uridine Triphosphate | 1997 |
Assignment and pH dependence of the 19F-NMR resonances from the fluorouracil anabolites involved in fluoropyrimidine chemotherapy.
Topics: Antineoplastic Agents; Fluorouracil; Humans; Hydrogen-Ion Concentration; Magnesium; Magnetic Resonance Spectroscopy; Uridine Triphosphate | 1999 |
Enhancement of the anti-tumor activity of S-1 by low-dose cisplatin in mice bearing the sarcoma-180 model.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Cisplatin; Drug Combinations; Fluorouracil; Male; Mice; Mice, Inbred Strains; Oxonic Acid; Pyridines; RNA, Neoplasm; Sarcoma 180; Tegafur; Thymidine Kinase; Uridine Triphosphate | 2005 |
Molecular characterization of a dual inhibitory and mutagenic activity of 5-fluorouridine triphosphate on viral RNA synthesis. Implications for lethal mutagenesis.
Topics: Animals; Antimetabolites; Base Sequence; Cell Line; Fluorouracil; Foot-and-Mouth Disease Virus; Genome, Viral; Humans; Mutagenesis; RNA-Dependent RNA Polymerase; RNA, Viral; Uridine Monophosphate; Uridine Triphosphate; Viral Proteins; Virus Replication | 2008 |
Development of an LC-MS/MS assay for the quantitative determination of the intracellular 5-fluorouracil nucleotides responsible for the anticancer effect of 5-fluorouracil.
Topics: Antineoplastic Agents; Biological Transport; Biotransformation; Calibration; Chromatography, Liquid; Deoxyuracil Nucleotides; Drug Monitoring; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Leukocytes, Mononuclear; Linear Models; Reference Standards; Reproducibility of Results; Tandem Mass Spectrometry; Uridine Triphosphate | 2015 |
Exploring the intracellular pharmacokinetics of the 5-fluorouracil nucleotides during capecitabine treatment.
Topics: Antimetabolites, Antineoplastic; Area Under Curve; Capecitabine; Chromatography, Liquid; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Deoxyuracil Nucleotides; Deoxyuridine; Fluorouracil; Humans; Leukocytes, Mononuclear; Neoplasms; Tandem Mass Spectrometry; Uridine Triphosphate | 2016 |
On a New Proposed Mechanism of 5-Fluorouracil-Mediated Cytotoxicity.
Topics: Cell Cycle; Cell Survival; DNA Damage; Fluorouracil; Humans; Methylation; Neoplasms; Recombinational DNA Repair; RNA, Transfer; tRNA Methyltransferases; Uridine Triphosphate | 2020 |