fluorouracil has been researched along with 5-(2-bromovinyl)uracil in 8 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 4 (50.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ashida, N; Baba, M; Ikeda, T; Machida, H; Sakata, S; Shigeta, S | 1 |
| Balzarini, J; Bricaud, H; De Clercq, E; Desgranges, C; Drouillet, F; Herdewijn, P; Razaka, G | 1 |
| Akimoto, S; Kataoka, K; Kinouchi, T; Matsuda, Y; Nakayama, H; Ohnishi, Y | 1 |
| Kato, A; Ogura, K; Okuda, H; Takubo, H; Watabe, T | 1 |
| Bellemann, ME; Brix, G; Haberkorn, U | 1 |
| Ito, K; Kanamitsu, SI; Muro, K; Ogura, K; Okuda, H; Sugiyama, Y; Watabe, T | 1 |
| Balzarini, J; Carangio, A; De Clercq, E; Esnouf, R; Liekens, S; McGuigan, C; Sienaert, R; Van Kuilenburg, A | 1 |
| Nishiyama, T; Ogura, K; Watabe, T | 1 |
1 review(s) available for fluorouracil and 5-(2-bromovinyl)uracil
| Article | Year |
|---|---|
[Molecular toxicological mechanism of the lethal interactions of the new antiviral drug, sorivudine, with 5-fluorouracil prodrugs and genetic deficiency of dihydropyrimidine dehydrogenase].
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Bromouracil; Dihydrouracil Dehydrogenase (NADP); Drug Interactions; Drug Therapy, Combination; Fluorouracil; Humans; NADP; Oxidoreductases; Prodrugs; Rats | 2002 |
1 trial(s) available for fluorouracil and 5-(2-bromovinyl)uracil
| Article | Year |
|---|---|
Prediction of in vivo drug-drug interactions based on mechanism-based inhibition from in vitro data: inhibition of 5-fluorouracil metabolism by (E)-5-(2-Bromovinyl)uracil.
Topics: Adult; Aged; Animals; Antimetabolites; Antiviral Agents; Area Under Curve; Blood Proteins; Blotting, Western; Bromouracil; Cytosol; Depression, Chemical; Drug Interactions; Female; Fluorouracil; Half-Life; Humans; Luminescent Measurements; Male; Middle Aged; Protein Binding; Rats | 2000 |
6 other study(ies) available for fluorouracil and 5-(2-bromovinyl)uracil
| Article | Year |
|---|---|
In vitro drug combination of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil with anti-human immunodeficiency virus or anticancer nucleosides.
Topics: Antiviral Agents; Arabinofuranosyluracil; Bromouracil; Cytarabine; Drug Combinations; Floxuridine; Fluorouracil; Herpesvirus 3, Human; HIV-1; Humans; Zidovudine | 1992 |
Effect of (E)-5-(2-bromovinyl)uracil on the catabolism and antitumor activity of 5-fluorouracil in rats and leukemic mice.
Topics: Animals; Bromouracil; Dihydrouracil Dehydrogenase (NADP); Drug Synergism; Fluorouracil; Leukemia P388; Leukemia, Experimental; Liver; Metabolic Clearance Rate; Mice; Oxidoreductases; Pyrimidines; Rats; Thymidine; Thymine; Uracil | 1986 |
Intestinal anaerobic bacteria hydrolyse sorivudine, producing the high blood concentration of 5-(E)-(2-bromovinyl)uracil that increases the level and toxicity of 5-fluorouracil.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Bacteria, Anaerobic; Bacteroides; Biotransformation; Bromouracil; Cecum; Fluorouracil; Gastric Mucosa; Gastrointestinal Contents; Intestinal Mucosa; Kidney; Liver; Male; Organ Specificity; Pentosyltransferases; Pyrimidine Phosphorylases; Rats; Rats, Sprague-Dawley | 1997 |
A possible mechanism of eighteen patient deaths caused by interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs.
Topics: Animals; Antimetabolites, Antineoplastic; Antiviral Agents; Arabinofuranosyluracil; Bromouracil; Cause of Death; Dihydrouracil Dehydrogenase (NADP); Drug Interactions; Fluorouracil; Half-Life; Herpes Zoster; Humans; Liver; Neoplasms; Oxidoreductases; Prodrugs; Rats; Tissue Distribution | 1998 |
Biochemical modulation of the catabolism and tissue uptake of the anticancer drug 5-fluorouracil by 5-bromovinyluracil: assessment with metabolic (19)F MR imaging.
Topics: Animals; Antimetabolites, Antineoplastic; beta-Alanine; Biotransformation; Bromouracil; Cell Division; Dose-Response Relationship, Drug; Fluorouracil; Immunologic Factors; Liver; Liver Neoplasms, Experimental; Magnetic Resonance Imaging; Male; Muscle, Skeletal; Neoplasm Transplantation; Rats; Rats, Inbred ACI; Tissue Distribution; Tumor Cells, Cultured | 1999 |
Lack of susceptibility of bicyclic nucleoside analogs, highly potent inhibitors of varicella-zoster virus, to the catabolic action of thymidine phosphorylase and dihydropyrimidine dehydrogenase.
Topics: Animals; Antiviral Agents; Binding Sites; Bromodeoxyuridine; Bromouracil; Dihydrouracil Dehydrogenase (NADP); Drug Interactions; Escherichia coli; Fluorouracil; Herpesvirus 3, Human; Heterocyclic Compounds, 2-Ring; Humans; Mice; Models, Molecular; Nucleosides; Oxidoreductases; Substrate Specificity; Thymidine Phosphorylase | 2002 |