fluorouracil and 4-butyrolactone

fluorouracil has been researched along with 4-butyrolactone in 8 studies

Research

Studies (8)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (12.50)	18.7374
1990's	2 (25.00)	18.2507
2000's	1 (12.50)	29.6817
2010's	4 (50.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Fukuoka, K; Hirano, T; Hosaka, K; Matsumoto, Y; Mitsuhashi, H; Naito, T; Oka, K	1
Au, JL; Sadée, W	1
Basaki, Y; Chikahisa, L; Hashimoto, A; Miyadera, K; Okabe, S; Wierzba, K; Yamada, Y; Yonekura, K	1
Angelino, NJ; Chow, KC; Dolnick, BJ; Dolnick, R; Stephanie, LV; Sufrin, JR; Wu, Q	1
Matsushima, E; Nagayama, S; Yamamiya, I; Yoshisue, K	1
Ishiguro, H; Takeuchi, M; Tanaka, S; Toi, M; Tsuji, W; Ueno, T	1
Adebayo, BO; Chang, TC; Deng, L; Hsiao, M; Huang, CC; Lee, WH; Lin, YC; Rao, YK; Tzeng, YM; Wang, LS; Wu, AT; Wu, CH; Yeh, CT	1
Chen, MC; Cho, TY; Kuo, YH; Lee, TH	1

Trials

1 trial(s) available for fluorouracil and 4-butyrolactone

Article	Year
Orally administered S-1 suppresses circulating endothelial cell counts in metastatic breast cancer patients. International journal of clinical oncology, 2014, Volume: 19, Issue:3 Topics: 4-Butyrolactone; Administration, Oral; Adult; Aged; Antigens, CD34; Antimetabolites, Antineoplastic; Breast Neoplasms; Cell Count; Chemokine CCL2; Drug Combinations; Endothelial Cells; Female; Fluorouracil; Humans; Middle Aged; Neovascularization, Pathologic; Oxonic Acid; Tegafur; Thrombospondin 1; Treatment Outcome; Vascular Endothelial Growth Factor A	2014

Article

Year

Orally administered S-1 suppresses circulating endothelial cell counts in metastatic breast cancer patients.

International journal of clinical oncology, 2014, Volume: 19, Issue:3

Topics: 4-Butyrolactone; Administration, Oral; Adult; Aged; Antigens, CD34; Antimetabolites, Antineoplastic; Breast Neoplasms; Cell Count; Chemokine CCL2; Drug Combinations; Endothelial Cells; Female; Fluorouracil; Humans; Middle Aged; Neovascularization, Pathologic; Oxonic Acid; Tegafur; Thrombospondin 1; Treatment Outcome; Vascular Endothelial Growth Factor A

2014

Other Studies

7 other study(ies) available for fluorouracil and 4-butyrolactone

Article	Year
Antiproliferative activity of mammalian lignan derivatives against the human breast carcinoma cell line, ZR-75-1. Cancer investigation, 1990, Volume: 8, Issue:6 Topics: 4-Butyrolactone; Adenosine Triphosphatases; Animals; Benzyl Compounds; Breast Neoplasms; Butylene Glycols; Cell Division; Cell Line; Dogs; Dose-Response Relationship, Drug; Fluorouracil; Humans; Kidney Cortex; Lethal Dose 50; Lignans; Ouabain	1990
Activation of Ftorafue [R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil] to 5-fluorouracil and gamma-butyrolactone. Cancer research, 1980, Volume: 40, Issue:8 Pt 1 Topics: 4-Butyrolactone; Animals; Biotransformation; Cell-Free System; Chromatography, Gas; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Fluorouracil; Furans; Humans; Male; Metabolic Clearance Rate; Mice; Microsomes, Liver; Rabbits; Tegafur	1980
UFT and its metabolites inhibit the angiogenesis induced by murine renal cell carcinoma, as determined by a dorsal air sac assay in mice. Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:8 Topics: 4-Butyrolactone; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cell Division; Diffusion Chambers, Culture; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Hydroxybutyrates; Kidney Neoplasms; Male; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neovascularization, Pathologic; Tegafur; Tumor Cells, Cultured; Uracil	1999
Enhancement of 5-fluorouracil sensitivity by an rTS signaling mimic in H630 colon cancer cells. Cancer research, 2005, Jul-01, Volume: 65, Issue:13 Topics: 4-Butyrolactone; Antineoplastic Combined Chemotherapy Protocols; Biomimetic Materials; Cell Line, Tumor; Colonic Neoplasms; Down-Regulation; Drug Synergism; Fluorouracil; Homoserine; Humans; Isoenzymes; Phosphorylation; Protein Isoforms; RNA, Antisense; Signal Transduction; Thymidylate Synthase; Tubulin	2005
Formation pathways of gamma-butyrolactone from the furan ring of tegafur during its conversion to 5-fluorouracil. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:8 Topics: 4-Butyrolactone; Aldehydes; Aryl Hydrocarbon Hydroxylases; Butanols; Cytochrome P-450 CYP2A6; Cytosol; DNA, Complementary; Fluorouracil; Furans; Humans; Liver; Microsomes, Liver; Phenylhydrazines; Sodium Oxybate; Tegafur; Thymidine Phosphorylase	2010
4-Acetylantroquinonol B inhibits colorectal cancer tumorigenesis and suppresses cancer stem-like phenotype. Toxicology and applied pharmacology, 2015, Oct-15, Volume: 288, Issue:2 Topics: 4-Butyrolactone; Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Cell Proliferation; Colorectal Neoplasms; Cyclohexanones; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Fluorouracil; Gene Expression Regulation, Neoplastic; HCT116 Cells; HT29 Cells; Humans; Leucovorin; Mice, Inbred NOD; Mice, SCID; Neoplastic Stem Cells; Organoplatinum Compounds; Phenotype; Signal Transduction; Spheroids, Cellular; Time Factors; Tumor Burden; Xenograft Model Antitumor Assays	2015
Meroterpenoids from a Medicinal Fungus Antrodia cinnamomea. Journal of natural products, 2017, 09-22, Volume: 80, Issue:9 Topics: 4-Butyrolactone; Antrodia; Cyclohexanones; Fluorouracil; Fungi; Humans; Molecular Structure; Structure-Activity Relationship; Taiwan; Terpenes; Ubiquinone	2017