fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether and sevoflurane

fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether has been researched along with sevoflurane in 96 studies

Research

Studies (96)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	48 (50.00)	18.2507
2000's	45 (46.88)	29.6817
2010's	3 (3.13)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Mazze, RI	2
Brown, BR; Brown, EA; Frink, EJ; Malan, TP; Malcomson, M; Morgan, SE	1
Fujii, K; Imai, M; Kawai, Y; Kawakami, U; Mizuno, T; Morio, M; Negishi, A; Ogasawara, Y; Satoh, N; Tamura, T	1
Fee, JP; Luney, SR; Murray, JM	1
Eger, EI; Fang, ZX	1
Baillie, TA; Davis, MR; Jin, L; Kharasch, ED	1
Eger, EI; Ferrell, LD; Gonsowski, CT; Kerschmann, RL; Laster, MJ	2
Callan, C; Cusick, PK; Delgado-Herrera, L; Friedman, MB; Hoffman, GM; Keller, KA; Krasula, RW; Prokocimer, P; Wooding, WL	1
Eger, EI; Kandel, L; Kerschmann, RL; Laster, MJ; Martin, JL; Reed, GF	1
Eger, EI; Fang, ZX; Ionescu, P; Kandel, L; Laster, MJ	1
Foden, ND; Jones, RM; Kenna, JG; Munday, IT; Van Pelt, FN; Ward, PM	1
Hankins, DC; Kharasch, ED	1
Eger, EI; Ionescu, P; Koblin, DD; Weiskopf, RB	1
Kharasch, ED; Spracklin, DK	1
Baillie, TA; Davis, MR; Doss, GA; Jin, L; Kharasch, ED	1
Aldrete, JA	1
Cunningham, DD; Grabenkort, RW; Huang, S; Mayoral, J; Webster, J	1
Bowland, T; Eger, EI; Fang, Z; Gong, D; Ionescu, P; Koblin, DD; Laster, MJ; Sonner, J; Weiskopf, RB	1
Garton, K; Hankins, DC; Kharasch, ED; Kilty, CG; Thorning, D	1
Artru, A; Bowdle, TA; Frink, EJ; Kharasch, ED; Nogami, WM; Zager, R	1
Anders, MW; Iyer, RA	1
Bowland, T; Eger, EI; Fang, Z; Gong, D; Ionescu, P; Laster, MJ; Sonner, J; Weiskopf, RB	1
Eger, EI; Ionescu, P; Laster, MJ; Weiskopf, RB	1
Bowland, T; Eger, EI; Gong, D; Ionescu, P; Koblin, DD; Laster, MJ; Weiskopf, RB	2
Eger, EI; Gong, D; Ionescu, P; Kerschmann, RL; Laster, MJ; Weiskopf, RB	1
Eger, EI; Gong, D; Ionescu, P; Laster, MJ; Steffey, EP; Weiskopf, RB	1
Kharasch, ED	2
Bito, H; Ikeda, K; Ikeuchi, Y	1
Ebert, TJ; Messana, LD; Staacke, TS; Uhrich, TD	1
Bito, H; Ikeda, K; Moriwaki, G	1
Ebert, TJ; Frink, EJ; Kharasch, ED	1
Anders, MW; Ebert, TJ; Frink, EJ; Iyer, RA	1
Gadawski, J; Muir, WW	1
Anders, MW; Baggs, RB; Iyer, RA; Uttamsingh, V	1
Frink, EJ	1
Hobbhahn, J; Taeger, K; Wiesner, G	1
Igarashi, M; Iwasaki, H; Namiki, A; Watanabe, H	1
Borkowf, CB; Marchick, MR; Martin, JL; Njoku, DB; Pohl, LR; Sokoloski, EA	1
Afshar, M; Cantillo, J; Deal, E; Goldberg, ME; Gratz, I; Larijani, G; McDougall, R; Vekeman, D; Zafeiridis, A	1
Osawa, M; Shinomura, T	1
Holzki, J; Kretz, FJ	1
Dudziak, R; Eger, EI; Förster, H; Gong, DH; Laster, MJ; Neumann, MA; Weiskopf, RB	1
Eger, EI; Goldberg, ME; Larijani, GE	1
Jubert, C; Kharasch, ED	1
Funk, W; Gruber, M; Hobbhahn, J; Jakob, W	1
Asskali, F; Behne, M; Dudziak, R; Förster, H; Warnken, UH	1
Bito, H; Katoh, T; Sanjo, Y; Sato, S; Suzuki, A	1
Brown, R; Dudziak, R; Eger, EI; Laster, MJ; Stabernack, CR	1
Bito, H; Katoh, T; Obata, R; Sato, S	1
Chen, X; Iwasaki, S; Namiki, A; Tsujiguchi, N; Yamada, S; Yamakage, M	1
Adachi, Y; Arimura, S; Higuchi, H; Kanno, M; Satoh, T	1
Bouche, MP; De Leenheer, AP; Mortier, EP; Rolly, G; Struys, MM; Van Bocxlaer, JF; Van Der Herten, C; Versichelen, LF	1
Bito, H; Ikeuchi, Y; Katoh, T; Moriwaki, G; Obata, R; Ohmura, M; Sato, S	1
Goto, K; Higuchi, H; Kanno, M; Satoh, T; Usui, Y; Wada, H	1
Bouche, MP; De Leenheer, AP; Mortier, E; Rolly, G; Struys, MM; Van Bocxlaer, JF; Versichelen, LF	1
Adachi, Y; Higuchi, H; Kanno, M; Satoh, T; Wada, H	2
Conzen, P; Czerner, S; Gröger, G; Peter, K; Reichle, FM	1
Eger, EI	1
Chen, X; Kamada, Y; Kimura, A; Namiki, A; Tsujiguchi, N; Yamakage, M	1
Arain, SR; Ebert, TJ; Mchaourab, A	1
Bouche, MP; de Leenheer, AP; Mortier, E; Rolly, G; Struys, M; Van Bocxlaer, J; Versichelen, L	1
Bouche, MP; De Leenheer, AP; Mortier, EP; Rolly, G; Struys, MM; Van Bocxlaer, JF; Versichelen, LF	2
Begay, C; Gandolfi, AJ; Lind, RC; Zheng, XH	1
Catania, JM; Gandolfi, AJ; Parrish, AR	1
Artru, A; Frink, EJ; Kharasch, ED; Michalowski, P; Nogami, W; Rooke, GA	1
Altuntas, TG; Kharasch, ED	1
Artru, AA; Kharasch, ED; Powers, KM	1
Gentz, BA; Malan, TP	1
Gul Altuntas, T; Kharasch, ED	1
Di Filippo, A; Dugheri, S; Focardi, L; Marini, F; Novelli, GP; Pacenti, M	1
Artru, AA; Conzen, PF; Czerner, SF; Ebert, TJ; Kharasch, ED; Michalowski, P; Reichle, FM; Rooke, GA; Weiss, BM	1
Eger, EI; Ferrell, LD; Förster, H; Hanks, DK; Stabernack, CR; Warnken, UH	1
Bito, H; Katoh, T; Kobayashi, S; Obata, Y; Sato, S	1
Conzen, PF; Reichle, FM	1
Hirabayashi, G; Isshiki, A; Kakinuma, T; Matsumoto, S; Mitsui, T; Ogihara, Y; Yasuo, W	1
Eger, EI; Saidman, LJ	1
Altuntas, TG; Kharasch, ED; Zager, RA	1
Altuntas, TG; Kharasch, ED; Park, SB	1
Bouche, MP; Dyzers, D; Goeteyn, W; Mortier, EP; Rolly, G; Struys, MM; Van Bocxlaer, JF; Vandevivere, YD; Versichelen, LF	1
Altuntas, TG; Kharasch, ED; Liggitt, HD; Schroeder, JL; Sheffels, P	1
Bito, H; Katoh, T; Kobayashi, S; Morita, K; Sato, S	1
Fujii, K; Fukuda, H; Kawamoto, M; Yuge, O	1
Kharasch, ED; Liggitt, HD; Schroeder, JL; Sheffels, P	1
Bammler, T; Beyer, R; Kharasch, ED; Schroeder, JL; Srinouanprachanh, S	1
de Lange, JJ; Keijzer, C; Perez, RS	1
Bellugi, I; Dugheri, S; Focardi, L; Gambi, D; Marini, F; Pacenti, M; Tulli, G	1
Namiki, A; Satoh, JI; Takahashi, K; Takahashi, M; Yamakage, M	1
Gong, YL; Li, EY; Li, Y; Liu, SJ; Sun, B; Wang, CS; Zhou, YM	2
Gong, YL; Li, EY; Li, Y; Li, YC; Liu, SJ; Wang, CS; Zhang, YN; Zhou, YM	1

Reviews

5 review(s) available for fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether and sevoflurane

Article	Year
[Compound A: toxicology and clinical relevance]. Der Anaesthesist, 1998, Volume: 47 Suppl 1 Topics: Anesthetics, Inhalation; Animals; Ethers; Humans; Hydrocarbons, Fluorinated; Kidney; Methyl Ethers; Rats; Sevoflurane	1998
[Kidney function in test subjects: published results and clinical relevance]. Der Anaesthesist, 1998, Volume: 47 Suppl 1 Topics: Anesthetics, Inhalation; Ethers; Humans; Hydrocarbons, Fluorinated; Kidney; Kidney Function Tests; Methyl Ethers; Sevoflurane	1998
[Occupational exposure and environmental pollution: the role of inhalation anesthetics with special consideration of sevoflurane]. Der Anaesthesist, 1998, Volume: 47 Suppl 1 Topics: Anesthesiology; Anesthetics, Inhalation; Animals; Environmental Pollution; Ethers; Humans; Hydrocarbons, Fluorinated; Methyl Ethers; Mutagenicity Tests; Mutagens; Occupational Exposure; Sevoflurane	1998
Renal toxicity with sevoflurane: a storm in a teacup? Drugs, 2001, Volume: 61, Issue:15 Topics: Air Movements; Anesthetics, Inhalation; Drug Interactions; Ethers; Gases; Humans; Hydrocarbons, Fluorinated; Kidney; Kidney Diseases; Methyl Ethers; Sevoflurane	2001
Halogenated inhalational anaesthetics. Best practice & research. Clinical anaesthesiology, 2003, Volume: 17, Issue:1 Topics: Anesthetics, Inhalation; Animals; Desflurane; Enflurane; Ethers; Halothane; Humans; Hydrocarbons, Fluorinated; Isoflurane; Kidney; Liver; Methyl Ethers; Organ Specificity; Sevoflurane	2003

Trials

22 trial(s) available for fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether and sevoflurane

Article	Year
Sevoflurane degradation by soda lime in a circle breathing system. Anaesthesia, 1996, Volume: 51, Issue:7 Topics: Adult; Anesthesia, Closed-Circuit; Anesthetics, Inhalation; Calcium Compounds; Drug Administration Schedule; Ethers; Humans; Hydrocarbons, Fluorinated; Methyl Ethers; Oxides; Sevoflurane; Sodium Hydroxide; Temperature	1996
Assessment of low-flow sevoflurane and isoflurane effects on renal function using sensitive markers of tubular toxicity. Anesthesiology, 1997, Volume: 86, Issue:6 Topics: Acetylglucosaminidase; Adult; Aged; Alanine Transaminase; Anesthesia, General; Anesthetics, Inhalation; Aspartate Aminotransferases; Biomarkers; Blood Urea Nitrogen; Creatinine; Ethers; Female; Fluorides; Glutathione Transferase; Humans; Hydrocarbons, Fluorinated; Isoflurane; Kidney; Kidney Tubular Necrosis, Acute; L-Lactate Dehydrogenase; Liver; Male; Methyl Ethers; Middle Aged; Sevoflurane	1997
Partly exhausted soda lime or soda lime with water added, inhibits the increase in compound A concentration in the circle system during low-flow sevoflurane anaesthesia. British journal of anaesthesia, 1997, Volume: 79, Issue:6 Topics: Adult; Aged; Anesthesia, Closed-Circuit; Anesthetics, Inhalation; Calcium Compounds; Carbon Dioxide; Ethers; Humans; Hydrocarbons, Fluorinated; Methyl Ethers; Middle Aged; Oxides; Sevoflurane; Sodium Hydroxide; Temperature; Time Factors; Water	1997
Clinical evaluation of low-flow sevoflurane anaesthesia for paediatric patients. Acta anaesthesiologica Scandinavica, 1999, Volume: 43, Issue:1 Topics: Anesthesia, Closed-Circuit; Anesthetics, Inhalation; Calcium Compounds; Carbon Dioxide; Child; Child, Preschool; Chromatography, Gas; Ethers; Female; Humans; Humidity; Hydrocarbons, Fluorinated; Infant; Male; Methyl Ethers; Nitrous Oxide; Oxides; Oxygen; Sevoflurane; Sodium Hydroxide; Temperature; Tidal Volume; Time Factors	1999
Compound A uptake and metabolism to mercapturic acids and 3,3,3-trifluoro-2-fluoromethoxypropanoic acid during low-flow sevoflurane anesthesia: biomarkers for exposure, risk assessment, and interspecies comparison. Anesthesiology, 1999, Volume: 91, Issue:5 Topics: Acetylation; Acetylcysteine; Adult; Aged; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Cysteine; Elective Surgical Procedures; Ethers; Female; Gas Chromatography-Mass Spectrometry; Glutathione; Humans; Hydrocarbons, Fluorinated; Inactivation, Metabolic; Male; Methyl Ethers; Middle Aged; Propionates; Rats; Sevoflurane	1999
[The use of lithium hydroxide for carbon dioxide absorption prevents formation of compound A during sevoflurane anesthesia]. Der Anaesthesist, 2000, Volume: 49, Issue:2 Topics: Absorption; Anesthesia, Inhalation; Anesthetics, Inhalation; Carbon Dioxide; Ethers; Female; Fluorides; Humans; Hydrocarbons, Fluorinated; Indicators and Reagents; Lithium Compounds; Male; Methyl Ethers; Middle Aged; Sevoflurane; Temperature	2000
Comparison of compound A concentrations with sevoflurane anaesthesia using a closed system with a PhysioFlex anaesthesia machine vs a low-flow system with a conventional anaesthesia machine. British journal of anaesthesia, 2000, Volume: 84, Issue:3 Topics: Adult; Aged; Anesthesia, Closed-Circuit; Anesthesia, Inhalation; Anesthetics, Inhalation; Calcium Compounds; Ethers; Humans; Hydrocarbons, Fluorinated; Methyl Ethers; Middle Aged; Oxides; Sevoflurane; Sodium Hydroxide; Temperature	2000
Carbon dioxide absorbents containing potassium hydroxide produce much larger concentrations of compound A from sevoflurane in clinical practice. Anesthesia and analgesia, 2000, Volume: 91, Issue:1 Topics: Absorption; Anesthesia, General; Anesthetics, Inhalation; Carbon Dioxide; Chromatography, Gas; Ethers; Female; Humans; Hydrocarbons, Fluorinated; Hydroxides; Male; Methyl Ethers; Middle Aged; Potassium Compounds; Sevoflurane	2000
Compound A concentrations during low-flow sevoflurane anesthesia correlate directly with the concentration of monovalent bases in carbon dioxide absorbents. Anesthesia and analgesia, 2000, Volume: 91, Issue:2 Topics: Absorption; Anesthesia, General; Anesthetics, Inhalation; Calcium Chloride; Calcium Hydroxide; Carbon Dioxide; Ethers; Female; Humans; Hydrocarbons, Fluorinated; Male; Methyl Ethers; Middle Aged; Sevoflurane	2000
The effects of prolonged low-flow sevoflurane anesthesia on renal and hepatic function. Anesthesia and analgesia, 2000, Volume: 91, Issue:5 Topics: Acetylglucosaminidase; Alanine Transaminase; Albuminuria; Alkaline Phosphatase; Anesthetics, Inhalation; Aspartate Aminotransferases; Blood Urea Nitrogen; Creatinine; Ethers; Fluorides; Glycosuria; Head and Neck Neoplasms; Humans; Hydrocarbons, Fluorinated; Isoflurane; Kidney; L-Lactate Dehydrogenase; Liver; Methyl Ethers; Middle Aged; Proteinuria; Sevoflurane	2000
Effects of probenecid on renal function in surgical patients anesthetized with low-flow sevoflurane. Anesthesiology, 2001, Volume: 94, Issue:1 Topics: Adult; Anesthesia, Inhalation; Anesthetics, Inhalation; beta 2-Microglobulin; Blood Pressure; Blood Urea Nitrogen; Creatinine; Ethers; Glucose; Humans; Hydrocarbons, Fluorinated; Kidney; Male; Methyl Ethers; Postoperative Period; Probenecid; Sevoflurane; Uricosuric Agents	2001
[Low alkali-hydroxide content in soda limes does not lead to reduction of compound A formation from sevoflurane during low-flow anesthesia]. Der Anaesthesist, 2001, Volume: 50, Issue:3 Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Calcium Compounds; Carbon Dioxide; Cholecystectomy, Laparoscopic; Chromatography, Gas; Ethers; Hemodynamics; Humans; Hydrocarbons, Fluorinated; Hydroxides; Methyl Ethers; Oxides; Sevoflurane; Sodium Hydroxide	2001
Production of compound A under low-flow anesthesia is affected by type of anesthetic machine. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2001, Volume: 48, Issue:5 Topics: Anesthesia, Inhalation; Anesthesiology; Anesthetics, Inhalation; Calcium Compounds; Ethers; Female; Gases; Humans; Hydrocarbons, Fluorinated; Male; Methyl Ethers; Middle Aged; Oxides; Sevoflurane; Sex Characteristics; Sodium Hydroxide	2001
Lack of degradation of sevoflurane by a new carbon dioxide absorbent in humans. Anesthesiology, 2001, Volume: 94, Issue:6 Topics: Absorption; Adult; Anesthesia, Inhalation; Anesthetics, Inhalation; Barium Compounds; Blood Gas Analysis; Calcium Chloride; Calcium Compounds; Calcium Hydroxide; Ethers; Female; Humans; Hydrocarbons, Fluorinated; Male; Methyl Ethers; Oxides; Sevoflurane; Sodium Hydroxide	2001
Long-duration low-flow sevoflurane and isoflurane effects on postoperative renal and hepatic function. Anesthesia and analgesia, 2001, Volume: 93, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Alanine Transaminase; Anesthetics, Inhalation; Aspartate Aminotransferases; Breath Tests; Ethers; Female; Fluorides; Humans; Hydrocarbons, Fluorinated; Isoflurane; Kidney; Liver; Male; Methyl Ethers; Middle Aged; Sevoflurane; Time Factors	2001
Comparison of plasma alpha glutathione S-transferase concentrations during and after low-flow sevoflurane or isoflurane anaesthesia. Acta anaesthesiologica Scandinavica, 2001, Volume: 45, Issue:10 Topics: Adult; Alanine Transaminase; Anesthesia, Inhalation; Anesthetics, Inhalation; Biomarkers; Ethers; Glutathione Transferase; Humans; Hydrocarbons, Fluorinated; Isoenzymes; Isoflurane; Liver; Male; Methyl Ethers; Sevoflurane	2001
Low-flow sevoflurane compared with low-flow isoflurane anesthesia in patients with stable renal insufficiency. Anesthesiology, 2002, Volume: 97, Issue:3 Topics: Aged; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Urea Nitrogen; Creatinine; Ethers; Female; Fluorides; Glycosuria; Humans; Hydrocarbons, Fluorinated; Isoflurane; Kidney Function Tests; Male; Methyl Ethers; Proteinuria; Renal Insufficiency; Sevoflurane	2002
No compound a formation with Superia during minimal-flow sevoflurane anesthesia: a comparison with Sofnolime. Anesthesia and analgesia, 2002, Volume: 95, Issue:6 Topics: Absorption; Adult; Aged; Anesthetics, Inhalation; Carbon Dioxide; Ethers; Female; Humans; Hydrocarbons, Fluorinated; Hydroxides; Male; Methyl Ethers; Middle Aged; Potassium Compounds; Sevoflurane; Sodium Hydroxide	2002
Compound A concentration in the circle absorber system during low-flow sevoflurane anesthesia: comparison of Drägersorb Free, Amsorb, and Sodasorb II. Journal of clinical anesthesia, 2003, Volume: 15, Issue:1 Topics: Absorption; Adult; Anesthesia, Inhalation; Anesthetics, Inhalation; Calcium Chloride; Calcium Hydroxide; Carbon Dioxide; Ethers; Female; Humans; Hydrocarbons, Fluorinated; Male; Methyl Ethers; Middle Aged; Sevoflurane	2003
A comparison of the effects of prolonged (>10 hour) low-flow sevoflurane, high-flow sevoflurane, and low-flow isoflurane anaesthesia on hepatorenal function in orthopaedic patients. Anaesthesia and intensive care, 2004, Volume: 32, Issue:2 Topics: Adult; Anesthesia, Inhalation; Anesthetics, Inhalation; Biomarkers; Chromatography, Gas; Ethers; Female; Hepatorenal Syndrome; Humans; Hydrocarbons, Fluorinated; Isoflurane; Kidney; Kidney Function Tests; Liver; Liver Function Tests; Male; Methyl Ethers; Sevoflurane; Surgical Flaps; Time Factors	2004
Compound A, formaldehyde and methanol concentrations during low-flow sevoflurane anaesthesia: comparison of three carbon dioxide absorbers. Acta anaesthesiologica Scandinavica, 2007, Volume: 51, Issue:5 Topics: Adsorption; Aged; Anesthesia, Inhalation; Anesthetics, Inhalation; Calcium Chloride; Calcium Compounds; Calcium Hydroxide; Carbon Dioxide; Equipment Safety; Ethers; Formaldehyde; Humans; Hydrocarbons, Fluorinated; Methanol; Methyl Ethers; Middle Aged; Oxides; Sevoflurane; Sodium Hydroxide; Time Factors	2007
A comparison between vital capacity induction and tidal breathing induction techniques for the induction of anesthesia and compound A production. Chinese medical journal, 2010, Volume: 123, Issue:17 Topics: Adult; Anesthesia, Inhalation; Anesthetics, Inhalation; Ethers; Female; Hemodynamics; Humans; Hydrocarbons, Fluorinated; Methyl Ethers; Middle Aged; Sevoflurane; Temperature; Tidal Volume; Vital Capacity	2010

Other Studies

69 other study(ies) available for fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether and sevoflurane

Article	Year
The safety of sevoflurane in humans. Anesthesiology, 1992, Volume: 77, Issue:6 Topics: Anesthetics; Animals; Ethers; Female; Humans; Hydrocarbons, Fluorinated; Male; Methyl Ethers; Rats; Rats, Wistar; Safety; Sevoflurane	1992
Quantification of the degradation products of sevoflurane in two CO2 absorbants during low-flow anesthesia in surgical patients. Anesthesiology, 1992, Volume: 77, Issue:6 Topics: Absorption; Anesthesia, Closed-Circuit; Anesthetics; Barium; Barium Compounds; Calcium Compounds; Calcium Hydroxide; Carbon Dioxide; Ethers; Gas Chromatography-Mass Spectrometry; Humans; Hydrocarbons, Fluorinated; Methyl Ethers; Oxides; Potassium; Potassium Compounds; Sevoflurane; Sodium Hydroxide; Surgical Procedures, Operative	1992
Reaction of sevoflurane and its degradation products with soda lime. Toxicity of the byproducts. Anesthesiology, 1992, Volume: 77, Issue:6 Topics: Absorption; Acute Disease; Anesthetics; Animals; Calcium Compounds; Carbon Dioxide; Chronic Disease; Ethers; Female; Hydrocarbons, Fluorinated; Male; Methyl Ethers; Mutagenicity Tests; Oxides; Rats; Rats, Wistar; Sevoflurane; Sodium Hydroxide	1992
Molecular sieves: an alternative method of carbon dioxide removal which does not generate compound A during simulated low-flow sevoflurane anaesthesia. Anaesthesia, 1995, Volume: 50, Issue:10 Topics: Adsorption; Anesthesia; Anesthetics; Calcium Compounds; Carbon Dioxide; Chromatography, Gel; Ethers; Humans; Hydrocarbons, Fluorinated; Methyl Ethers; Oxides; Sevoflurane; Sodium Hydroxide	1995
Factors affecting the concentration of compound A resulting from the degradation of sevoflurane by soda lime and Baralyme in a standard anesthetic circuit. Anesthesia and analgesia, 1995, Volume: 81, Issue:3 Topics: Absorption; Anesthesia; Barium Compounds; Calcium Compounds; Calcium Hydroxide; Carbon Dioxide; Ethers; Hydrocarbons, Fluorinated; Methyl Ethers; Oxides; Potassium Compounds; Respiration, Artificial; Sevoflurane; Sodium Hydroxide; Vinyl Compounds	1995
Nephrotoxicity of sevoflurane compound A [fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether] in rats: evidence for glutathione and cysteine conjugate formation and the role of renal cysteine conjugate beta-lyase. Biochemical and biophysical research communications, 1995, May-16, Volume: 210, Issue:2 Topics: Animals; Carbon-Sulfur Lyases; Cysteine; Ethers; Glutathione; Hydrocarbons, Fluorinated; Kidney; Lyases; Male; Mass Spectrometry; Methyl Ethers; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Sevoflurane	1995
Toxicity of compound A in rats. Effect of increasing duration of administration. Anesthesiology, 1994, Volume: 80, Issue:3 Topics: Anesthetics; Animals; Body Weight; Cell Division; Dose-Response Relationship, Drug; Drug Administration Schedule; Ethers; Hydrocarbons, Fluorinated; Immunohistochemistry; Kidney Diseases; Lethal Dose 50; Lung Diseases; Male; Methyl Ethers; Nuclear Proteins; Proliferating Cell Nuclear Antigen; Pulmonary Edema; Rats; Rats, Wistar; Regeneration; Sevoflurane; Time Factors	1994
Toxicity of compound A in rats. Effect of a 3-hour administration. Anesthesiology, 1994, Volume: 80, Issue:3 Topics: Anesthetics; Animals; Brain; Brain Diseases; Dose-Response Relationship, Drug; Drug Administration Schedule; Ethers; Hydrocarbons, Fluorinated; Kidney Diseases; Lethal Dose 50; Male; Methyl Ethers; Rats; Rats, Wistar; Sevoflurane; Time Factors	1994
Inhalation toxicity study of a haloalkene degradant of sevoflurane, Compound A (PIFE), in Sprague-Dawley rats. Anesthesiology, 1995, Volume: 83, Issue:6 Topics: Anesthetics, Inhalation; Animals; Blood Chemical Analysis; Blood Coagulation; Dose-Response Relationship, Drug; Ethers; Female; Hydrocarbons, Fluorinated; Kidney Diseases; Male; Methyl Ethers; Nasal Mucosa; Rats; Rats, Sprague-Dawley; Sevoflurane	1995
Metabolism of compound A by renal cysteine-S-conjugate beta-lyase is not the mechanism of compound A-induced renal injury in the rat. Anesthesia and analgesia, 1996, Volume: 82, Issue:4 Topics: Aminooxyacetic Acid; Anesthetics, Inhalation; Animals; Buthionine Sulfoximine; Carbon-Sulfur Lyases; Enzyme Inhibitors; Ethers; Glutathione; Hydrocarbons, Fluorinated; Isoxazoles; Kidney; Kidney Diseases; Lyases; Male; Methionine Sulfoximine; Methyl Ethers; Rats; Rats, Wistar; Sevoflurane	1996
Factors affecting production of compound A from the interaction of sevoflurane with Baralyme and soda lime. Anesthesia and analgesia, 1996, Volume: 82, Issue:4 Topics: Absorption; Anesthetics, Inhalation; Barium Compounds; Calcium Compounds; Calcium Hydroxide; Ethers; Hydrocarbons, Fluorinated; Hydrogen-Ion Concentration; Methyl Ethers; Oxides; Potassium Compounds; Sevoflurane; Sodium Hydroxide; Temperature; Water	1996
P450-dependent and nonenzymatic human liver microsomal defluorination of fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), a sevoflurane degradation product. Drug metabolism and disposition: the biological fate of chemicals, 1996, Volume: 24, Issue:6 Topics: Anesthetics, Inhalation; Cytochrome P-450 CYP2E1; Ethers; Fluorides; Humans; Hydrocarbons, Fluorinated; Methyl Ethers; Microsomes, Liver; NADP; Sevoflurane	1996
Compound A: solubility in saline and olive oil; destruction by blood. Anesthesia and analgesia, 1996, Volume: 83, Issue:4 Topics: Anesthetics, Inhalation; Animals; Binding Sites; Biotransformation; Blood Proteins; Erythrocytes; Ethers; Ethylmaleimide; Hemoglobins; Hot Temperature; Humans; Hydrocarbons, Fluorinated; Methyl Ethers; Olive Oil; Plant Oils; Plasma; Protein Binding; Rats; Rats, Sprague-Dawley; Serum Albumin; Sevoflurane; Sodium Chloride; Solubility; Solvents; Sulfhydryl Reagents	1996
Evidence for metabolism of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), a sevoflurane degradation product, by cysteine conjugate beta-lyase. Chemical research in toxicology, 1996, Volume: 9, Issue:4 Topics: Aminooxyacetic Acid; Anesthetics, Inhalation; Animals; Carbon-Sulfur Lyases; Enzyme Inhibitors; Ethers; Fluorine; Gas Chromatography-Mass Spectrometry; Humans; Hydrocarbons, Fluorinated; Injections, Intraperitoneal; Kidney; Lyases; Magnetic Resonance Spectroscopy; Male; Methyl Ethers; Propionates; Rats; Rats, Inbred F344; Sevoflurane	1996
Identification in rat bile of glutathione conjugates of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether, a nephrotoxic degradate of the anesthetic agent sevoflurane. Chemical research in toxicology, 1996, Volume: 9, Issue:2 Topics: Animals; Bile; Chromatography, Liquid; Ethers; Glutathione; Hydrocarbons, Fluorinated; Kidney; Male; Mass Spectrometry; Methyl Ethers; Microsomes, Liver; Protein Binding; Rats; Rats, Sprague-Dawley; Sevoflurane	1996
Compound A concentrations during sevoflurane anesthesia in children depend on fresh gas flow. Anesthesiology, 1996, Volume: 85, Issue:3 Topics: Anesthesia; Anesthetics, Inhalation; Carbon Dioxide; Child; Child, Preschool; Ethers; Humans; Hydrocarbons, Fluorinated; Infant; Methyl Ethers; Sevoflurane	1996
Sevoflurane degradation to compound A in anaesthesia breathing systems. British journal of anaesthesia, 1996, Volume: 77, Issue:4 Topics: Absorption; Anesthesia, Inhalation; Anesthetics, Inhalation; Ethers; Humans; Hydrocarbons, Fluorinated; Methyl Ethers; Models, Chemical; Sevoflurane; Temperature	1996
Nephrotoxicity of sevoflurane versus desflurane anesthesia in volunteers. Anesthesia and analgesia, 1997, Volume: 84, Issue:1 Topics: Adult; Albuminuria; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Urea Nitrogen; Creatinine; Desflurane; Ethers; Fluorides; Glutathione Transferase; Glycosuria; Humans; Hydrocarbons, Fluorinated; Isoflurane; Kidney; Kidney Function Tests; Liver; Male; Methyl Ethers; Sevoflurane	1997
Role of renal cysteine conjugate beta-lyase in the mechanism of compound A nephrotoxicity in rats. Anesthesiology, 1997, Volume: 86, Issue:1 Topics: Aminooxyacetic Acid; Anesthetics, Inhalation; Animals; Carbon-Sulfur Lyases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethers; Hydrocarbons, Fluorinated; Isoxazoles; Kidney; Lyases; Male; Methyl Ethers; Probenecid; Rats; Rats, Inbred F344; Sevoflurane	1997
Cysteine conjugate beta-lyase-dependent biotransformation of the cysteine S-conjugates of the sevoflurane degradation product 2-(fluoromethoxy)-1,1,3,3,3-pentafluoro-1-propene (compound A). Chemical research in toxicology, 1997, Volume: 10, Issue:7 Topics: Anesthetics, Inhalation; Animals; Biotransformation; Carbon-Sulfur Lyases; Cysteine; Cytosol; Ethers; Hydrocarbons, Fluorinated; In Vitro Techniques; Kidney; Lyases; Magnetic Resonance Spectroscopy; Male; Methyl Ethers; Rats; Rats, Inbred F344; Sevoflurane; Spectrophotometry, Ultraviolet	1997
Recovery and kinetic characteristics of desflurane and sevoflurane in volunteers after 8-h exposure, including kinetics of degradation products. Anesthesiology, 1997, Volume: 87, Issue:3 Topics: Anesthetics, Inhalation; Desflurane; Ethers; Humans; Hydrocarbons, Fluorinated; Isoflurane; Male; Methyl Ethers; Sevoflurane; Time Factors	1997
Baralyme dehydration increases and soda lime dehydration decreases the concentration of compound A resulting from sevoflurane degradation in a standard anesthetic circuit. Anesthesia and analgesia, 1997, Volume: 85, Issue:4 Topics: Anesthetics, Inhalation; Barium Compounds; Calcium Compounds; Calcium Hydroxide; Ethers; Humans; Hydrocarbons, Fluorinated; Methyl Ethers; Oxides; Potassium Compounds; Sevoflurane; Sodium Hydroxide; Temperature	1997
Dose-related biochemical markers of renal injury after sevoflurane versus desflurane anesthesia in volunteers. Anesthesia and analgesia, 1997, Volume: 85, Issue:5 Topics: Adult; Anesthesia, General; Anesthetics, Inhalation; Biomarkers; Chemical and Drug Induced Liver Injury; Desflurane; Dose-Response Relationship, Drug; Ethers; Fluorides; Humans; Hydrocarbons, Fluorinated; Isoflurane; Kidney Diseases; Kidney Glomerulus; Liver Diseases; Male; Methyl Ethers; Sevoflurane; Temperature; Tidal Volume	1997
Quantitative differences in the production and toxicity of CF2=BrCl versus CH2F-O-C(=CF2)(CF3) (compound A): the safety of halothane does not indicate the safety of sevoflurane. Anesthesia and analgesia, 1997, Volume: 85, Issue:5 Topics: Absorption; Aminooxyacetic Acid; Anesthetics, Inhalation; Animals; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Ethers; Halothane; Humans; Hydrocarbons, Fluorinated; Hydrocarbons, Halogenated; Isoxazoles; Kidney Diseases; Lyases; Methyl Ethers; Rats; Rats, Inbred F344; Rats, Wistar; Sevoflurane	1997
Dehydration of Baralyme increases compound A resulting from sevoflurane degradation in a standard anesthetic circuit used to anesthetize swine. Anesthesia and analgesia, 1997, Volume: 85, Issue:6 Topics: Anesthesia, Closed-Circuit; Anesthetics, Inhalation; Animals; Barium Compounds; Calcium Hydroxide; Dehydration; Ethers; Hydrocarbons, Fluorinated; Methyl Ethers; Potassium Compounds; Sevoflurane; Swine; Temperature	1997
Pharmacovigilance and safety aspects of sevoflurane. Acta anaesthesiologica Scandinavica. Supplementum, 1997, Volume: 111 Topics: Adult; Adverse Drug Reaction Reporting Systems; Anesthetics, Inhalation; Chemical and Drug Induced Liver Injury; Child; Drug Evaluation; Ethers; Fluorides; Heart; Humans; Hydrocarbons, Fluorinated; Kidney; Methyl Ethers; Product Surveillance, Postmarketing; Safety; Sevoflurane; United States; United States Food and Drug Administration	1997
Effects of the water content of soda lime on compound A concentration in the anesthesia circuit in sevoflurane anesthesia. Anesthesiology, 1998, Volume: 88, Issue:1 Topics: Anesthesia, Closed-Circuit; Anesthetics, Inhalation; Calcium Compounds; Carbon Dioxide; Ethers; Humans; Hydrocarbons, Fluorinated; Methyl Ethers; Oxides; Sevoflurane; Sodium Hydroxide; Water	1998
The effect of anesthetic duration on kinetic and recovery characteristics of desflurane versus sevoflurane, and on the kinetic characteristics of compound A, in volunteers. Anesthesia and analgesia, 1998, Volume: 86, Issue:2 Topics: Adult; Anesthesia; Anesthetics, Inhalation; Desflurane; Ethers; Humans; Hydrocarbons, Fluorinated; Isoflurane; Male; Methyl Ethers; Perception; Sevoflurane; Time Factors; Volunteers	1998
Absence of renal and hepatic toxicity after four hours of 1.25 minimum alveolar anesthetic concentration sevoflurane anesthesia in volunteers. Anesthesia and analgesia, 1998, Volume: 86, Issue:3 Topics: Alanine Transaminase; Anesthetics, Inhalation; Body Temperature; Ethers; Glutathione Transferase; Glycosuria; Hemodynamics; Hydrocarbons, Fluorinated; Kidney; Liver; Methyl Ethers; Proteinuria; Sevoflurane; Time Factors	1998
Absence of biochemical evidence for renal and hepatic dysfunction after 8 hours of 1.25 minimum alveolar concentration sevoflurane anesthesia in volunteers. Anesthesiology, 1998, Volume: 88, Issue:3 Topics: Adult; Alanine Transaminase; Anesthetics, Inhalation; Body Temperature; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Ethers; Glutathione Transferase; Glycosuria; Humans; Hydrocarbons, Fluorinated; Kidney; Kidney Diseases; Liver; Methyl Ethers; Proteinuria; Sevoflurane; Volunteers	1998
Cysteine conjugate beta-lyase-dependent metabolism of compound A (2-[fluoromethoxy]-1,1,3,3,3-pentafluoro-1-propene) in human subjects anesthetized with sevoflurane and in rats given compound A. Anesthesiology, 1998, Volume: 88, Issue:3 Topics: Anesthetics, Inhalation; Animals; Carbon-Sulfur Lyases; Ethers; Hydrocarbons, Fluorinated; Lyases; Methyl Ethers; Nuclear Magnetic Resonance, Biomolecular; Rats; Rats, Inbred F344; Sevoflurane; Volunteers	1998
Cardiorespiratory effects of low-flow and closed circuit inhalation anesthesia, using sevoflurane delivered with an in-circuit vaporizer and concentrations of compound A. American journal of veterinary research, 1998, Volume: 59, Issue:5 Topics: Anesthesia, Closed-Circuit; Anesthetics, Inhalation; Animals; Dogs; Ethers; Hemodynamics; Hydrocarbons, Fluorinated; Methyl Ethers; Nebulizers and Vaporizers; Respiration, Artificial; Sevoflurane	1998
Fate and toxicity of 2-(fluoromethoxy)-1,1,3,3,3-pentafluoro-1-propene (compound A)-derived mercapturates in male, Fischer 344 rats. Anesthesiology, 1998, Volume: 89, Issue:5 Topics: Acetylcysteine; Acyltransferases; Anesthetics, Inhalation; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Cytosol; Dealkylation; Drug Contamination; Ethers; Hydrocarbons, Fluorinated; Kidney Diseases; Magnetic Resonance Spectroscopy; Male; Methyl Ethers; Rats; Rats, Inbred F344; Sevoflurane	1998
Immunochemical evidence against the involvement of cysteine conjugate beta-lyase in compound A nephrotoxicity in rats. Anesthesiology, 1999, Volume: 90, Issue:2 Topics: Anesthetics, Inhalation; Animals; Carbon-Sulfur Lyases; Ethers; Hydrocarbons, Fluorinated; Kidney; Male; Methyl Ethers; Necrosis; Rats; Rats, Wistar; Sevoflurane	1999
Dose of compound A, not sevoflurane, determines changes in the biochemical markers of renal injury in healthy volunteers. Anesthesia and analgesia, 1999, Volume: 88, Issue:2 Topics: Adolescent; Adult; Albuminuria; Anesthesia, Closed-Circuit; Anesthetics, Inhalation; Area Under Curve; Biomarkers; Chromatography, Gas; Dose-Response Relationship, Drug; Ethers; Follow-Up Studies; Glutathione Transferase; Glycosuria; Humans; Hydrocarbons, Fluorinated; Kidney; Male; Methyl Ethers; Sevoflurane; Spirometry	1999
Compound A concentration is decreased by cooling anaesthetic circuit during low-flow sevoflurane anaesthesia. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1998, Volume: 45, Issue:12 Topics: Absorption; Anesthesia, Inhalation; Anesthetics, Inhalation; Body Temperature; Calcium Compounds; Carbon Dioxide; Chromatography, Gas; Cold Temperature; Equipment Design; Ethers; Female; Follow-Up Studies; Humans; Hydrocarbons, Fluorinated; Ice; Male; Methyl Ethers; Middle Aged; Nitrous Oxide; Oxides; Oxygen; Respiration; Sevoflurane; Sodium Hydroxide; Water	1998
Changing aspects of sevoflurane in paediatric anaesthesia: 1975-99. Paediatric anaesthesia, 1999, Volume: 9, Issue:4 Topics: Akathisia, Drug-Induced; Anesthesia, Inhalation; Anesthetics, Inhalation; Arrhythmias, Cardiac; Child; Child, Preschool; Delirium; Ethers; Halothane; Humans; Hydrocarbons, Fluorinated; Methyl Ethers; Nitrous Oxide; Seizures; Sevoflurane; Time Factors	1999
The elimination of sodium and potassium hydroxides from desiccated soda lime diminishes degradation of desflurane to carbon monoxide and sevoflurane to compound A but does not compromise carbon dioxide absorption. Anesthesia and analgesia, 1999, Volume: 89, Issue:3 Topics: Absorption; Anesthetics, Inhalation; Calcium Compounds; Carbon Dioxide; Carbon Monoxide; Chromatography, Gas; Desflurane; Desiccation; Ethers; Hydrocarbons, Fluorinated; Hydroxides; Isoflurane; Methyl Ethers; Oxides; Potassium Compounds; Sevoflurane; Sodium Hydroxide	1999
Peripheral neuropathy in healthy men volunteers anesthetized with 1.25 MAC sevoflurane for 8 hours. Pharmacotherapy, 1999, Volume: 19, Issue:10 Topics: Adult; Anesthesia; Anesthetics, Inhalation; Ethers; Humans; Hydrocarbons, Fluorinated; Male; Methyl Ethers; Peripheral Nervous System Diseases; Sevoflurane; Time Factors	1999
Compound A does not accumulate during closed circuit sevoflurane anaesthesia with the Physioflex. British journal of anaesthesia, 1999, Volume: 83, Issue:4 Topics: Aged; Anesthesia, Closed-Circuit; Anesthetics, Inhalation; Calcium Compounds; Ethers; Female; Gas Scavengers; Humans; Hydrocarbons, Fluorinated; Inhalation; Male; Methyl Ethers; Middle Aged; Oxides; Sevoflurane; Sodium Hydroxide; Temperature	1999
Absorbents differ enormously in their capacity to produce compound A and carbon monoxide. Anesthesia and analgesia, 2000, Volume: 90, Issue:6 Topics: Adsorption; Anesthetics, Inhalation; Calcium Hydroxide; Carbon Monoxide; Chromatography, Gas; Desflurane; Ethers; Hydrocarbons, Fluorinated; Hydroxides; Isoflurane; Lithium Compounds; Methyl Ethers; Potassium Compounds; Sevoflurane; Sodium Hydroxide; Time Factors	2000
[The compound A concentration in a low-flow anesthesia circuit using the new CO2 absorbent SPHERASORB]. Masui. The Japanese journal of anesthesiology, 2000, Volume: 49, Issue:5 Topics: Absorption; Anesthesia, Closed-Circuit; Anesthetics, Inhalation; Animals; Carbon Dioxide; Ethers; Hydrocarbons, Fluorinated; Methyl Ethers; Rats; Sevoflurane; Temperature	2000
In vitro compound A formation in a computer-controlled closed-circuit anesthetic apparatus. Comparison with a classical valve circuit. Anesthesiology, 2000, Volume: 93, Issue:4 Topics: Anesthesia, Closed-Circuit; Anesthetics, Inhalation; Carbon Dioxide; Computers; Drug Stability; Ethers; Humans; Hydrocarbons, Fluorinated; Methyl Ethers; Models, Biological; Partial Pressure; Positive-Pressure Respiration; Sevoflurane; Ventilators, Mechanical	2000
Quantitative determination of vapor-phase compound A in sevoflurane anesthesia using gas chromatography-mass spectrometry. Clinical chemistry, 2001, Volume: 47, Issue:2 Topics: Air; Anesthetics, Inhalation; Ethers; Gas Chromatography-Mass Spectrometry; Hydrocarbons, Fluorinated; Methyl Ethers; Reproducibility of Results; Sensitivity and Specificity; Sevoflurane; Volatilization	2001
The effects of low-flow sevoflurane and isoflurane anesthesia on renal function in patients with stable moderate renal insufficiency. Anesthesia and analgesia, 2001, Volume: 92, Issue:3 Topics: Aged; Anesthesia, Inhalation; Area Under Curve; Creatinine; Ethers; Female; Humans; Hydrocarbons, Fluorinated; Isoflurane; Kidney; Male; Methyl Ethers; Middle Aged; Renal Insufficiency; Sevoflurane	2001
Composition of CO(2) absorbents. Anesthesia and analgesia, 2001, Volume: 92, Issue:5 Topics: Absorption; Anesthetics, Inhalation; Carbon Dioxide; Carbon Monoxide; Desflurane; Ethers; Hydrocarbons, Fluorinated; Isoflurane; Methyl Ethers; Sevoflurane	2001
Compound A: does it matter? Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2001, Volume: 48, Issue:5 Topics: Adsorption; Anesthetics, Inhalation; Canada; Carbon Dioxide; Ethers; Humans; Hydrocarbons, Fluorinated; Kidney Diseases; Methyl Ethers; Sevoflurane	2001
Compound A production from sevoflurane is not less when KOH-free absorbent is used in a closed-circuit lung model system. British journal of anaesthesia, 2001, Volume: 86, Issue:3 Topics: Absorption; Anesthesia, Closed-Circuit; Anesthetics, Inhalation; Calcium Compounds; Carbon Dioxide; Ethers; Humans; Hydrocarbons, Fluorinated; Hydroxides; Lung; Methyl Ethers; Models, Biological; Oxides; Potassium Compounds; Sevoflurane; Sodium Hydroxide	2001
Only carbon dioxide absorbents free of both NaOH and KOH do not generate compound A during in vitro closed-system sevoflurane: evaluation of five absorbents. Anesthesiology, 2001, Volume: 95, Issue:3 Topics: Absorption; Anesthetics, Inhalation; Carbon Dioxide; Ethers; Humans; Hydrocarbons, Fluorinated; Hydroxides; Methyl Ethers; Potassium Compounds; Sevoflurane; Sodium Hydroxide; Temperature	2001
Humoral immune response to a sevoflurane degradation product in the guinea pig following inhalation exposure. Drug and chemical toxicology, 2001, Volume: 24, Issue:4 Topics: Alanine Transaminase; Anesthetics, Inhalation; Animals; Antibody Formation; Enzyme-Linked Immunosorbent Assay; Ethers; Guinea Pigs; Hydrocarbons, Fluorinated; Liver; Male; Methyl Ethers; Sevoflurane	2001
Toxicity of a sevoflurane degradation product incubated with rat liver and renal cortical slices. Drug and chemical toxicology, 2001, Volume: 24, Issue:4 Topics: Anesthetics, Inhalation; Animals; Cell Survival; Ethers; Glutathione; Hydrocarbons, Fluorinated; In Vitro Techniques; Kidney Cortex; Liver; Male; Methyl Ethers; Rats; Rats, Inbred F344; Sevoflurane	2001
Glutathione S-conjugation of the sevoflurane degradation product, fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human liver, kidney, and blood in vitro. Toxicology and applied pharmacology, 2001, Dec-01, Volume: 177, Issue:2 Topics: Anesthetics, Inhalation; Chromatography, Liquid; Cytosol; Ethers; Gas Chromatography-Mass Spectrometry; Glutathione; Humans; Hydrocarbons, Fluorinated; Kidney; Liver; Methyl Ethers; Microsomes, Liver; Sevoflurane	2001
Comparison of Amsorb, sodalime, and Baralyme degradation of volatile anesthetics and formation of carbon monoxide and compound a in swine in vivo. Anesthesiology, 2002, Volume: 96, Issue:1 Topics: Absorption; Anesthetics, Inhalation; Animals; Barium Compounds; Calcium Chloride; Calcium Compounds; Calcium Hydroxide; Carbon Monoxide; Carboxyhemoglobin; Desflurane; Ethers; Female; Hydrocarbons, Fluorinated; Isoflurane; Male; Methyl Ethers; Oxides; Potassium Compounds; Sevoflurane; Sodium Hydroxide; Swine	2002
Biotransformation of L-cysteine S-conjugates and N-acetyl-L-cysteine S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human kidney in vitro: interindividual variability in N-acety Drug metabolism and disposition: the biological fate of chemicals, 2002, Volume: 30, Issue:2 Topics: Acetylation; Acetylcysteine; Anesthetics, Inhalation; Biotransformation; Cysteine; Ethers; Free Radical Scavengers; Humans; Hydrocarbons, Fluorinated; Kidney; Lyases; Methyl Ethers; Sevoflurane	2002
Sevoflurane low-flow anaesthesia: best strategy to reduce Compound A concentration. Acta anaesthesiologica Scandinavica, 2002, Volume: 46, Issue:8 Topics: Absorption; Anesthesia, Closed-Circuit; Anesthetics, Inhalation; Carbon Dioxide; Ethers; Humans; Hydrocarbons, Fluorinated; In Vitro Techniques; Methyl Ethers; Sevoflurane	2002
Sevoflurane degradation by carbon dioxide absorbents may produce more than one nephrotoxic compound in rats. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2003, Volume: 50, Issue:3 Topics: Absorption; Anesthetics, Inhalation; Animals; Carbon Dioxide; Ethers; Hydrocarbons, Fluorinated; Kidney; Male; Methyl Ethers; Rats; Rats, Wistar; Sevoflurane	2003
Novel radiator for carbon dioxide absorbents in low-flow anesthesia. Annals of clinical and laboratory science, 2003,Summer, Volume: 33, Issue:3 Topics: Absorption; Anesthesia, Closed-Circuit; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Body Temperature; Calcium Compounds; Carbon Dioxide; Chromatography, Gas; Ethers; Female; Hydrocarbons, Fluorinated; Methyl Ethers; Oxides; Sevoflurane; Sodium Hydroxide; Swine; Temperature; Water	2003
Safety of low-flow sevoflurane anesthesia in patients with chronically impaired renal function is not proven. Anesthesiology, 2003, Volume: 99, Issue:3 Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Ethers; Humans; Hydrocarbons, Fluorinated; Kidney Failure, Chronic; Kidney Function Tests; Methyl Ethers; Proteinuria; Sevoflurane	2003
Cytotoxicity of S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl) vinyl ether (Compound A) in a human proximal tubular cell line. Toxicology and applied pharmacology, 2003, Nov-15, Volume: 193, Issue:1 Topics: Anesthetics, Inhalation; Cell Line; Cysteine; Ethers; Formazans; Glutathione; Humans; Hydrocarbons, Fluorinated; Kidney Diseases; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; Methyl Ethers; Sevoflurane; Tetrazolium Salts	2003
Sulfoxidation of cysteine and mercapturic acid conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A). Chemical research in toxicology, 2004, Volume: 17, Issue:3 Topics: Acetylcysteine; Anesthetics, Inhalation; Animals; Cysteine; Cytochrome P-450 Enzyme System; Ethers; Humans; Hydrocarbons, Fluorinated; Kidney; Methyl Ethers; Microsomes, Liver; Oxidation-Reduction; Rats; Sevoflurane; Sulfoxides	2004
Production of compound A and carbon monoxide in circle systems: an in vitro comparison of two carbon dioxide absorbents. Anaesthesia, 2004, Volume: 59, Issue:6 Topics: Absorption; Anesthesia, Closed-Circuit; Anesthetics, Inhalation; Calcium Chloride; Calcium Hydroxide; Carbon Dioxide; Carbon Monoxide; Desflurane; Ethers; Humans; Hydrocarbons, Fluorinated; Isoflurane; Methyl Ethers; Sevoflurane; Temperature	2004
Role of cytochrome P4503A in cysteine S-conjugates sulfoxidation and the nephrotoxicity of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in rats. Chemical research in toxicology, 2004, Volume: 17, Issue:9 Topics: Anesthetics, Inhalation; Animals; Aryl Hydrocarbon Hydroxylases; Cysteine; Cytochrome P-450 CYP3A; Dexamethasone; Ethers; Hydrocarbons, Fluorinated; Kidney Diseases; Lyases; Male; Methyl Ethers; Oxidoreductases, N-Demethylating; Phenobarbital; Propionates; Rats; Rats, Inbred F344; Sevoflurane; Sulfoxides; Troleandomycin	2004
Amsorb Plus and Drägersorb Free, two new-generation carbon dioxide absorbents that produce a low compound A concentration while providing sufficient CO2 absorption capacity in simulated sevoflurane anesthesia. Journal of anesthesia, 2004, Volume: 18, Issue:4 Topics: Absorption; Anesthesia; Anesthetics, Inhalation; Calcium Chloride; Calcium Hydroxide; Carbon Dioxide; Ethers; Hydrocarbons, Fluorinated; Methyl Ethers; Sevoflurane	2004
Influence of sevoflurane on the metabolism and renal effects of compound A in rats. Anesthesiology, 2005, Volume: 103, Issue:6 Topics: Anesthetics, Inhalation; Animals; Biotransformation; Ethers; Hydrocarbons, Fluorinated; Kidney; Kidney Diseases; Kidney Function Tests; Male; Methyl Ethers; Rats; Rats, Inbred F344; Sevoflurane; Sulfoxides	2005
Gene expression profiling of nephrotoxicity from the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether ("compound A") in rats. Toxicological sciences : an official journal of the Society of Toxicology, 2006, Volume: 90, Issue:2 Topics: Anesthetics, Inhalation; Animals; Ethers; Gene Expression Profiling; Hydrocarbons, Fluorinated; Kidney; Kidney Diseases; Male; Methyl Ethers; Oligonucleotide Array Sequence Analysis; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sevoflurane	2006
Compound A and carbon monoxide production from sevoflurane and seven different types of carbon dioxide absorbent in a patient model. Acta anaesthesiologica Scandinavica, 2007, Volume: 51, Issue:1 Topics: Absorption; Anesthesia, Closed-Circuit; Anesthetics, Inhalation; Carbon Dioxide; Carbon Monoxide; Chromatography, Gas; Ethers; Hydrocarbons, Fluorinated; Methyl Ethers; Models, Biological; Sevoflurane; Temperature	2007
Performance of four carbon dioxide absorbents in experimental and clinical settings. Anaesthesia, 2009, Volume: 64, Issue:3 Topics: Absorption; Anesthesia, Closed-Circuit; Anesthetics, Inhalation; Calcium Chloride; Calcium Compounds; Calcium Hydroxide; Carbon Dioxide; Color; Dust; Ethers; Gas Scavengers; Humans; Hydrocarbons, Fluorinated; Indicators and Reagents; Methyl Ethers; Oxides; Sevoflurane; Sodium Hydroxide	2009
Degradation products of different water content sevoflurane in carbon dioxide absorbents by gas chromatography-mass spectrometry analysis. Chinese medical journal, 2011, Volume: 124, Issue:7 Topics: Absorption; Carbon Dioxide; Ethers; Gas Chromatography-Mass Spectrometry; Hydrocarbons, Fluorinated; Methyl Ethers; Sevoflurane	2011
Sofnolime with different water content causes different effects in two sevoflurane inhalational induction techniques with respect to the output of compound-A. International journal of medical sciences, 2012, Volume: 9, Issue:6 Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Ethers; Hydrocarbons, Fluorinated; Methyl Ethers; Sevoflurane; Water	2012