fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether and cysteine

fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether has been researched along with cysteine in 8 studies

Research

Studies (8)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	4 (50.00)	18.2507
2000's	4 (50.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Baillie, TA; Davis, MR; Jin, L; Kharasch, ED	1
Anders, MW; Iyer, RA	1
Anders, MW; Baggs, RB; Iyer, RA	1
Jubert, C; Kharasch, ED	1
Gul Altuntas, T; Kharasch, ED	1
Altuntas, TG; Kharasch, ED; Zager, RA	1
Altuntas, TG; Kharasch, ED; Park, SB	1
Altuntas, TG; Kharasch, ED; Liggitt, HD; Schroeder, JL; Sheffels, P	1

Trials

1 trial(s) available for fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether and cysteine

Article	Year
Compound A uptake and metabolism to mercapturic acids and 3,3,3-trifluoro-2-fluoromethoxypropanoic acid during low-flow sevoflurane anesthesia: biomarkers for exposure, risk assessment, and interspecies comparison. Anesthesiology, 1999, Volume: 91, Issue:5 Topics: Acetylation; Acetylcysteine; Adult; Aged; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Cysteine; Elective Surgical Procedures; Ethers; Female; Gas Chromatography-Mass Spectrometry; Glutathione; Humans; Hydrocarbons, Fluorinated; Inactivation, Metabolic; Male; Methyl Ethers; Middle Aged; Propionates; Rats; Sevoflurane	1999

Article

Year

Compound A uptake and metabolism to mercapturic acids and 3,3,3-trifluoro-2-fluoromethoxypropanoic acid during low-flow sevoflurane anesthesia: biomarkers for exposure, risk assessment, and interspecies comparison.

Anesthesiology, 1999, Volume: 91, Issue:5

Topics: Acetylation; Acetylcysteine; Adult; Aged; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Cysteine; Elective Surgical Procedures; Ethers; Female; Gas Chromatography-Mass Spectrometry; Glutathione; Humans; Hydrocarbons, Fluorinated; Inactivation, Metabolic; Male; Methyl Ethers; Middle Aged; Propionates; Rats; Sevoflurane

1999

Other Studies

7 other study(ies) available for fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether and cysteine

Article	Year
Nephrotoxicity of sevoflurane compound A [fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether] in rats: evidence for glutathione and cysteine conjugate formation and the role of renal cysteine conjugate beta-lyase. Biochemical and biophysical research communications, 1995, May-16, Volume: 210, Issue:2 Topics: Animals; Carbon-Sulfur Lyases; Cysteine; Ethers; Glutathione; Hydrocarbons, Fluorinated; Kidney; Lyases; Male; Mass Spectrometry; Methyl Ethers; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Sevoflurane	1995
Cysteine conjugate beta-lyase-dependent biotransformation of the cysteine S-conjugates of the sevoflurane degradation product 2-(fluoromethoxy)-1,1,3,3,3-pentafluoro-1-propene (compound A). Chemical research in toxicology, 1997, Volume: 10, Issue:7 Topics: Anesthetics, Inhalation; Animals; Biotransformation; Carbon-Sulfur Lyases; Cysteine; Cytosol; Ethers; Hydrocarbons, Fluorinated; In Vitro Techniques; Kidney; Lyases; Magnetic Resonance Spectroscopy; Male; Methyl Ethers; Rats; Rats, Inbred F344; Sevoflurane; Spectrophotometry, Ultraviolet	1997
Nephrotoxicity of the glutathione and cysteine S-conjugates of the sevoflurane degradation product 2-(fluoromethoxy)-1,1,3,3, 3-pentafluoro-1-propene (Compound A) in male Fischer 344 rats. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 283, Issue:3 Topics: Anesthetics, Inhalation; Animals; Biotransformation; Blood Urea Nitrogen; Cysteine; Ethers; Glutathione; Hydrocarbons, Fluorinated; Kidney; Male; Rats; Rats, Inbred F344	1997
Biotransformation of L-cysteine S-conjugates and N-acetyl-L-cysteine S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human kidney in vitro: interindividual variability in N-acety Drug metabolism and disposition: the biological fate of chemicals, 2002, Volume: 30, Issue:2 Topics: Acetylation; Acetylcysteine; Anesthetics, Inhalation; Biotransformation; Cysteine; Ethers; Free Radical Scavengers; Humans; Hydrocarbons, Fluorinated; Kidney; Lyases; Methyl Ethers; Sevoflurane	2002
Cytotoxicity of S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl) vinyl ether (Compound A) in a human proximal tubular cell line. Toxicology and applied pharmacology, 2003, Nov-15, Volume: 193, Issue:1 Topics: Anesthetics, Inhalation; Cell Line; Cysteine; Ethers; Formazans; Glutathione; Humans; Hydrocarbons, Fluorinated; Kidney Diseases; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; Methyl Ethers; Sevoflurane; Tetrazolium Salts	2003
Sulfoxidation of cysteine and mercapturic acid conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A). Chemical research in toxicology, 2004, Volume: 17, Issue:3 Topics: Acetylcysteine; Anesthetics, Inhalation; Animals; Cysteine; Cytochrome P-450 Enzyme System; Ethers; Humans; Hydrocarbons, Fluorinated; Kidney; Methyl Ethers; Microsomes, Liver; Oxidation-Reduction; Rats; Sevoflurane; Sulfoxides	2004
Role of cytochrome P4503A in cysteine S-conjugates sulfoxidation and the nephrotoxicity of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in rats. Chemical research in toxicology, 2004, Volume: 17, Issue:9 Topics: Anesthetics, Inhalation; Animals; Aryl Hydrocarbon Hydroxylases; Cysteine; Cytochrome P-450 CYP3A; Dexamethasone; Ethers; Hydrocarbons, Fluorinated; Kidney Diseases; Lyases; Male; Methyl Ethers; Oxidoreductases, N-Demethylating; Phenobarbital; Propionates; Rats; Rats, Inbred F344; Sevoflurane; Sulfoxides; Troleandomycin	2004