Compounds > fluorodeoxyuridylate
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fluorodeoxyuridylate and levoleucovorin

fluorodeoxyuridylate has been researched along with levoleucovorin in 24 studies

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19909 (37.50)18.7374
1990's13 (54.17)18.2507
2000's1 (4.17)29.6817
2010's0 (0.00)24.3611
2020's1 (4.17)2.80

Authors

AuthorsStudies
Haurani, FI1
Fujiwara, Y; Nishio, K; Ohe, Y; Ohmori, T; Saijo, N; Sugimoto, Y1
Chen, TL; Erlichman, C1
Hoshi, A; Iigo, M; Nishikata, K1
Harstrick, A; Rustum, YM; Zhang, ZG1
Sasaki, T1
Bunni, MA; Priest, DG; Romero-Fredes, LR; Schmitz, JC; Whiteley, JM1
Berger, SH; Hakala, MT2
Frösing, R; Gustavsson, BG; Spears, CP1
Morgan, RG1
Dreyfuss, A; el-Magharbel, I; Frei, E; Holden, SA; Jones, SM; Rosowsky, A; Trites, D; Wright, JE1
Keyomarsi, K; Moran, RG; Patel, R1
Moran, RG; Newman, EM; Sato, JK1
Carlsson, G; Frösing, R; Gustavsson, BG; Spears, CP1
Allegra, CJ; Bagley, C; Chabner, BA; Drake, JC; Lippman, ME; Sholar, PW1
Braakhuis, BJ; De Jong, M; Peters, GJ; Pinedo, HM; Smid, K; Van der Wilt, CL1
Meijer, S; Peters, GJ; Pinedo, HM; Smid, K; van der Wilt, CL; van Groeningen, CJ1
Hoekman, K; Meijer, S; Peters, GJ; Pinedo, HM; Smid, K; van der Wilt, CL; van Groeningen, CJ1
Carlsson, G; Gustavsson, BG; Jaresko, G; Muggia, FM; Spears, CP1
Kuiper, CM; Peters, GJ; Pinedo, HM; Rustum, YM; Smid, K; Van der Wilt, CL; Van Laar, JA1
Aherne, GW; Allegra, CJ; Geoffroy, F; Grem, JL; Hardcastle, A; Johnston, PG; Ren, Q; Van Groeningen, CJ1
Griffiths, JR; Howe, FA; Lofts, F; McIntyre, DJ; McSheehy, PM; Nicholson, G; Noordhuis, P; Peters, GJ; Price, NM; Rodrigues, LM; Smid, K; Stubbs, M; Wadsworth, P1
Guo, J; Huang, L; Liu, Y; Sun, D; Yu, Z; Zou, Y1

Reviews

3 review(s) available for fluorodeoxyuridylate and levoleucovorin

ArticleYear
[High-dose leucovorin and 5-FU].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Evaluation; Fluorodeoxyuridylate; Fluorouracil; Humans; Leucovorin; Stomach Neoplasms; Thymidylate Synthase

1992
Leucovorin enhancement of the effects of the fluoropyrimidines on thymidylate synthase.
    Cancer, 1989, Mar-15, Volume: 63, Issue:6 Suppl

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Synergism; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Leucovorin; Neoplasms; Thymidylate Synthase

1989
Aspects of one-carbon folate cycling related to fluoropyrimidine and antifolate therapy.
    Cancer treatment and research, 1995, Volume: 78

    Topics: Animals; Antimetabolites, Antineoplastic; Fluorodeoxyuridylate; Fluorouracil; Folic Acid; Folic Acid Antagonists; Glycine Hydroxymethyltransferase; Humans; Leucovorin; Neoplasms

1995

Trials

1 trial(s) available for fluorodeoxyuridylate and levoleucovorin

ArticleYear
Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: implications for treatment with fluorouracil.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1994, Volume: 12, Issue:10

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Female; Fluorodeoxyuridylate; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Remission Induction; Thymidylate Synthase

1994

Other Studies

20 other study(ies) available for fluorodeoxyuridylate and levoleucovorin

ArticleYear
Inhibition of thymidylate synthetase of the human lymphocytes.
    Cancer biochemistry biophysics, 1979, Volume: 4, Issue:2

    Topics: Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Humans; Kinetics; Leucovorin; Lymphocytes; Methotrexate; Methyltransferases; Thymidylate Synthase

1979
In vitro enhancement of fluoropyrimidine-induced cytotoxicity by leucovorin in colorectal and gastric carcinoma cell lines but not in non-small-cell lung carcinoma cell lines.
    Cancer chemotherapy and pharmacology, 1992, Volume: 30, Issue:6

    Topics: Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Cell Survival; Colony-Forming Units Assay; Colorectal Neoplasms; Drug Synergism; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Leucovorin; Lung Neoplasms; Stomach Neoplasms; Tetrahydrofolates; Thymidylate Synthase; Tumor Cells, Cultured

1992
Biochemical modulation of 5-fluorouracil with or without leucovorin by a low dose of brequinar in MGH-U1 cells.
    Cancer chemotherapy and pharmacology, 1992, Volume: 30, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Biphenyl Compounds; Cell Survival; Cytidine Triphosphate; Deoxyuracil Nucleotides; Dose-Response Relationship, Drug; Drug Interactions; Fluorodeoxyuridylate; Fluorouracil; Humans; Hypoxanthine; Hypoxanthines; Leucovorin; Phosphoribosyl Pyrophosphate; Thymidylate Synthase; Tumor Cells, Cultured; Uridine Triphosphate

1992
In vivo antitumor effects of fluoropyrimidines on colon adenocarcinoma 38 and enhancement by leucovorin.
    Japanese journal of cancer research : Gann, 1992, Volume: 83, Issue:4

    Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Cell Division; Colonic Neoplasms; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Leucovorin; Male; Mice; Mice, Inbred Strains; Thymidylate Synthase; Uridine

1992
Mechanisms of resistance to fluoropyrimidines.
    Seminars in oncology, 1992, Volume: 19, Issue:2 Suppl 3

    Topics: Cecal Neoplasms; Deoxyuracil Nucleotides; Drug Resistance; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Ileal Neoplasms; Leucovorin; Tetrahydrofolates; Thymidylate Synthase; Tumor Cells, Cultured

1992
A sensitive radioenzymatic assay for (S)-5-formyltetrahydrofolate.
    Analytical biochemistry, 1991, Aug-01, Volume: 196, Issue:2

    Topics: Animals; Carbon-Nitrogen Ligases; Fluorodeoxyuridylate; Humans; Leucovorin; Ligases; Methods; Rabbits; Stereoisomerism; Thymidylate Synthase; Tritium

1991
Calcium leucovorin and 5-fluorouridine cytotoxicity.
    Journal of the South Carolina Medical Association (1975), 1990, Volume: 86, Issue:5

    Topics: Fluorodeoxyuridylate; Humans; Leucovorin; RNA, Ribosomal; Thymidylate Synthase; Tumor Cells, Cultured; Uridine

1990
Folinic acid modulation of fluorouracil: tissue kinetics of bolus administration.
    Investigational new drugs, 1989, Volume: 7, Issue:1

    Topics: Aged; Biotransformation; Colonic Neoplasms; Cytosol; Drug Interactions; Female; Fluorodeoxyuridylate; Fluorouracil; Humans; Lacticaseibacillus casei; Leucovorin; Male; Middle Aged; Thymidylate Synthase

1989
Selective expansion of 5,10-methylenetetrahydrofolate pools and modulation of 5-fluorouracil antitumor activity by leucovorin in vivo.
    Cancer research, 1989, May-15, Volume: 49, Issue:10

    Topics: Animals; Female; Fluorodeoxyuridylate; Fluorouracil; Leucovorin; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Tetrahydrofolates

1989
Tumor cell responses to inhibition of thymidylate synthase.
    Advances in experimental medicine and biology, 1988, Volume: 244

    Topics: Animals; Cell Line; Cell Survival; Drug Screening Assays, Antitumor; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Kinetics; Leucovorin; Protein Binding; Thymidylate Synthase; Tumor Cells, Cultured

1988
Preparation of (6R)-tetrahydrofolic acid and (6R)-5-formyltetrahydrofolic acid of high stereochemical purity.
    Analytical biochemistry, 1986, May-01, Volume: 154, Issue:2

    Topics: Fluorodeoxyuridylate; Lacticaseibacillus casei; Leucovorin; Oxidation-Reduction; Pediococcus; Protein Binding; Stereoisomerism; Tetrahydrofolates; Thymidylate Synthase

1986
Pharmacodynamics of 5-fluorouracil and leucovorin.
    Advances in experimental medicine and biology, 1988, Volume: 244

    Topics: Adenocarcinoma; Animals; Bone Marrow; Colonic Neoplasms; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Fluorouracil; Humans; Intestinal Mucosa; Leucovorin; Liver; Pancreatic Neoplasms; Rats; Rats, Inbred Strains; Rectal Neoplasms; Stomach Neoplasms; Thymidylate Synthase

1988
Preliminary results of a phase II trial for the treatment of metastatic breast cancer with 5-fluorouracil and leucovorin.
    NCI monographs : a publication of the National Cancer Institute, 1987, Issue:5

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Evaluation; Fluorodeoxyuridylate; Fluorouracil; Folic Acid; Humans; Leucovorin; Middle Aged; Neoplasm Metastasis; Thymidylate Synthase

1987
Relationship of dUMP and free FdUMP pools to inhibition of thymidylate synthase by 5-fluorouracil.
    Molecular pharmacology, 1984, Volume: 25, Issue:2

    Topics: Animals; Carcinoma; Cell Line; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Fluorouracil; Humans; Kinetics; Leucovorin; Methyltransferases; Sarcoma, Experimental; Thymidylate Synthase

1984
Addition of leucovorin in modulation of 5-fluorouracil with methotrexate: potentiating or reversing effect?
    International journal of cancer, 1995, May-29, Volume: 61, Issue:5

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Cell Division; Female; Fluorodeoxyuridylate; Fluorouracil; Humans; Leucovorin; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Tumor Cells, Cultured

1995
Potentiation of 5-fluorouracil induced inhibition of thymidylate synthase in human colon tumors by leucovorin is dose dependent.
    Advances in experimental medicine and biology, 1993, Volume: 338

    Topics: Binding Sites; Colonic Neoplasms; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Synergism; Fluorodeoxyuridylate; Fluorouracil; Humans; Kinetics; Leucovorin; Thymidylate Synthase

1993
Tumor size and origin determine the antitumor activity of cisplatin or 5-fluorouracil and its modulation by leucovorin in murine colon carcinomas.
    Cancer chemotherapy and pharmacology, 1996, Volume: 39, Issue:1-2

    Topics: Adenocarcinoma; Animals; Antidotes; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Colonic Neoplasms; Drug Interactions; Female; Fluorodeoxyuridylate; Fluorouracil; Immunosuppressive Agents; Leucovorin; Mice; Mice, Inbred BALB C; Weight Loss

1996
Determinants of cytotoxicity with prolonged exposure to fluorouracil in human colon cancer cells.
    Oncology research, 1997, Volume: 9, Issue:2

    Topics: Cell Division; Cell Survival; Colonic Neoplasms; Deoxyribonucleotides; Deoxyuracil Nucleotides; DNA Damage; DNA, Neoplasm; Dose-Response Relationship, Drug; Fluorodeoxyuridylate; Fluorouracil; Gene Expression Regulation, Enzymologic; Humans; Leucovorin; Thymidylate Synthase; Tumor Cells, Cultured; Uridine Triphosphate

1997
Issues of normal tissue toxicity in patient and animal studies--effect of carbogen breathing in rats after 5-fluorouracil treatment.
    Acta oncologica (Stockholm, Sweden), 2001, Volume: 40, Issue:5

    Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Biological Availability; Bone Marrow; Carbon Dioxide; Carcinoma, Transitional Cell; Colonic Neoplasms; Colorectal Neoplasms; Combined Modality Therapy; Fatal Outcome; Female; Fluorine Radioisotopes; Fluorodeoxyuridylate; Fluorouracil; Humans; Intestine, Small; Leucovorin; Liver; Liver Neoplasms; Magnetic Resonance Imaging; Middle Aged; Neoplasms, Multiple Primary; Oxygen; Rats; Rats, Inbred WF; Sigmoid Neoplasms; Tomography, X-Ray Computed; Ultrasonography; Urinary Bladder Neoplasms

2001
Two nanoformulations induce reactive oxygen species and immunogenetic cell death for synergistic chemo-immunotherapy eradicating colorectal cancer and hepatocellular carcinoma.
    Molecular cancer, 2021, 01-06, Volume: 20, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; B7-H1 Antigen; Carcinoma, Hepatocellular; Cell Line, Tumor; Colorectal Neoplasms; Disease Models, Animal; Drug Compounding; Drug Synergism; Female; Fluorodeoxyuridylate; Fluorouracil; Immunogenic Cell Death; Immunotherapy; Leucovorin; Liver Neoplasms; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Neoplasm Metastasis; Organoplatinum Compounds; Reactive Oxygen Species; Tissue Distribution

2021