fluorodeoxyuridylate has been researched along with folic acid in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (51.61) | 18.7374 |
| 1990's | 13 (41.94) | 18.2507 |
| 2000's | 2 (6.45) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Allegra, CJ; Boarman, D; Chu, E; Zinn, S | 1 |
| Keyomarsi, K; Moran, RG | 1 |
| Appelt, K; Matthews, DA; Oatley, SJ; Xuong, NH | 1 |
| Appelt, K; Matthews, DA; Oatley, SJ | 1 |
| Danenberg, PV; Frösing, R; Gustavsson, BG; Hayes, AA; Shahinian, AH; Spears, CP | 1 |
| Houghton, JA; Houghton, PJ; Radparvar, S | 1 |
| Maley, F; Maley, GF | 1 |
| Lu, Y; Newman, EM; Priest, DG; Scanlon, KJ | 1 |
| Allegra, CJ; Bagley, C; Chabner, BA; Drake, JC; Lippman, ME; Sholar, PW | 1 |
| Doig, MT; Priest, DG | 2 |
| Garvey, EP; Santi, DV | 1 |
| Ahmed, F; Dunlap, RB; Moore, MA | 1 |
| Danenberg, PV; Pellino, AM | 1 |
| Bertino, JR; Fernandes, DJ; Moroson, BA | 1 |
| Dunlap, RB; Ellis, PD; Lewis, CA | 1 |
| Baugh, CM; Bednarek, JM; Doig, MT; Happel, KK; Mangum, M; Priest, DG | 1 |
| Bertino, JR; Fernandes, DJ; Mini, E | 1 |
| Houghton, JA; Houghton, PJ; Schmidt, C | 1 |
| Carl, GF; Smith, ML | 1 |
| Connick, TJ; Dunlap, RB; Ellis, PD; Reilly, RT | 2 |
| de Jong, M; Peters, GJ; Pinedo, HM; van der Wilt, CL | 1 |
| Adachi, I; Hashimoto, T; Ishida, F; Kawakami, K; Matsu, T; Omura, K; Watanabe, Y | 1 |
| Cisneros, RJ; Dunlap, RB; Zapf, JW | 1 |
| Carlsson, G; Gustavsson, BG; Jaresko, G; Muggia, FM; Spears, CP | 1 |
| Dabrowska, M; Michalski, R; Pawelczak, K; Rode, W; Wranicz, M; Zieliñski, Z | 1 |
| Banerjee, D; Bertino, JR; Capiaux, GM; Ercikan-Abali, EA; Liu-Chen, X; Tong, Y; Zhao, SC | 1 |
| Biermann, D; Finer-Moore, J; Michelitsch, MD; Nissen, R; Sage, CR; Stout, TJ; Stroud, RM | 1 |
| Gmeiner, WH; Kolar, C; Lawson, TA; Liu, J | 1 |
| Anderson, KS; Atreya, CE; Chang, SY; Johnson, EF; Liang, PH; Williamson, J | 1 |
1 review(s) available for fluorodeoxyuridylate and folic acid
| Article | Year |
|---|---|
Aspects of one-carbon folate cycling related to fluoropyrimidine and antifolate therapy.
Topics: Animals; Antimetabolites, Antineoplastic; Fluorodeoxyuridylate; Fluorouracil; Folic Acid; Folic Acid Antagonists; Glycine Hydroxymethyltransferase; Humans; Leucovorin; Neoplasms | 1995 |
30 other study(ies) available for fluorodeoxyuridylate and folic acid
| Article | Year |
|---|---|
Interaction of gamma interferon and 5-fluorouracil in the H630 human colon carcinoma cell line.
Topics: Adenocarcinoma; Cell Division; Colonic Neoplasms; DNA; Drug Interactions; Drug Resistance; Fluorodeoxyuridylate; Fluorouracil; Folic Acid; Humans; Interferon-gamma; RNA; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Tumor Cells, Cultured | 1990 |
Quinazoline folate analogs inhibit the catalytic activity of thymidylate synthase but allow binding of 5-fluorodeoxyuridylate.
Topics: Animals; Binding Sites; Cytidine Monophosphate; Floxuridine; Fluorodeoxyuridylate; Folic Acid; Folic Acid Antagonists; Kinetics; Leukemia L1210; Mice; Models, Structural; Protein Binding; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase | 1990 |
Crystal structure of Escherichia coli thymidylate synthase containing bound 5-fluoro-2'-deoxyuridylate and 10-propargyl-5,8-dideazafolate.
Topics: Amino Acid Sequence; Binding Sites; Deoxyuracil Nucleotides; Escherichia coli; Fluorodeoxyuridylate; Folic Acid; Folic Acid Antagonists; Ligands; Models, Molecular; Molecular Sequence Data; Protein Binding; Protein Conformation; Quinazolines; Thymidylate Synthase | 1990 |
Crystal structure of Escherichia coli thymidylate synthase with FdUMP and 10-propargyl-5,8-dideazafolate.
Topics: Deoxyuracil Nucleotides; Escherichia coli; Fluorodeoxyuridylate; Folic Acid; Folic Acid Antagonists; Kinetics; Models, Molecular; Protein Binding; Protein Conformation; Quinazolines; Structure-Activity Relationship; Substrate Specificity; Thymidylate Synthase; X-Ray Diffraction | 1989 |
Deoxyuridylate effects on thymidylate synthase-5-fluorodeoxyuridylate-folate ternary complex formation.
Topics: Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Folic Acid; Kinetics; Thymidylate Synthase | 1989 |
Effect of polyglutamylation of 5,10-methylenetetrahydrofolate on the binding of 5-fluoro-2'-deoxyuridylate to thymidylate synthase purified from a human colon adenocarcinoma xenograft.
Topics: Adenocarcinoma; Colonic Neoplasms; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Folic Acid; Humans; In Vitro Techniques; Kinetics; Pteroylpolyglutamic Acids; Structure-Activity Relationship; Tetrahydrofolates; Thymidylate Synthase | 1989 |
Properties of a defined mutant of Escherichia coli thymidylate synthase.
Topics: Amino Acids; Cysteine; Escherichia coli; Fluorodeoxyuridylate; Folic Acid; Mutation; Peptide Mapping; Quinazolines; Structure-Activity Relationship; Tetrahydrofolates; Thymidylate Synthase; Tyrosine | 1988 |
Biochemical basis for cisplatin and 5-fluorouracil synergism in human ovarian carcinoma cells.
Topics: Carcinoma; Cell Line; Cisplatin; Drug Synergism; Female; Fluorodeoxyuridylate; Fluorouracil; Folic Acid; Humans; Ovarian Neoplasms; Tetrahydrofolates; Thymidine Monophosphate; Thymidylate Synthase | 1986 |
Preliminary results of a phase II trial for the treatment of metastatic breast cancer with 5-fluorouracil and leucovorin.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Evaluation; Fluorodeoxyuridylate; Fluorouracil; Folic Acid; Humans; Leucovorin; Middle Aged; Neoplasm Metastasis; Thymidylate Synthase | 1987 |
Tissue folate polyglutamate chain length determination by electrophoresis as thymidylate synthase-fluorodeoxyuridylate ternary complexes.
Topics: Animals; Deoxyuracil Nucleotides; Electrophoresis, Polyacrylamide Gel; Fluorodeoxyuridylate; Folic Acid; Liver; Protein Binding; Pteroylpolyglutamic Acids; Radioisotope Dilution Technique; Species Specificity; Spectrometry, Fluorescence; Structure-Activity Relationship; Thymidylate Synthase; Tritium | 1986 |
A stable binary complex between Leishmania major thymidylate synthase and the substrate deoxyuridylate. A slow-binding interaction.
Topics: Animals; Binding, Competitive; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Folic Acid; Kinetics; Leishmania tropica; Quinazolines; Thymidine Monophosphate; Thymidylate Synthase | 1987 |
Evidence for the existence of covalent nucleotide-thymidylate synthase complexes, identification of site of attachment, and enhancement by folates.
Topics: Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Folic Acid; Tetrahydrofolates; Thymidine Monophosphate; Thymidylate Synthase | 1986 |
Evidence from chemical degradation studies for a covalent bond from 5-fluoro-2'-deoxyuridylate to N-5 of tetrahydrofolate in the ternary complex of thymidylate synthetase-5-fluoro-2'-deoxyuridylate-5,10-methylenetetrahydrofolate.
Topics: Carbon Radioisotopes; Colorimetry; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Folic Acid; Lacticaseibacillus casei; Methyltransferases; Protein Binding; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thymidylate Synthase; Tritium | 1985 |
The role of methotrexate and dihydrofolate polyglutamates in the enhancement of fluorouracil action by methotrexate.
Topics: Animals; Cell Line; Cell Survival; Drug Administration Schedule; Drug Therapy, Combination; Fluorodeoxyuridylate; Fluorouracil; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Polyglutamic Acid; Pteroylpolyglutamic Acids; Thymidylate Synthase | 1981 |
Evaluation of folylpolyglutamates by electrophoretic separation of fluorodeoxyuridylate-thymidylate synthase-methylenetetrahydrofolate complexes.
Topics: Animals; Deoxyuracil Nucleotides; Electrophoresis, Polyacrylamide Gel; Fluorodeoxyuridylate; Folic Acid; Kinetics; Lacticaseibacillus casei; Liver; Methyltransferases; Mice; Protein Binding; Pteroylpolyglutamic Acids; Saccharomyces cerevisiae; Species Specificity; Tetrahydrofolates; Thymidylate Synthase | 1983 |
Fluorine-19 nuclear magnetic resonance characterization of ternary complexes of folate derivatives, 5-fluorodeoxyuridylate and Lactobacillus.
Topics: Aminopterin; Binding Sites; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Folic Acid; Folic Acid Antagonists; Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; Methotrexate; Methyltransferases; Protein Binding; Structure-Activity Relationship; Tetrahydrofolates; Thymidylate Synthase | 1981 |
Tissue folylpolyglutamate chain-length characterization by electrophoresis as thymidylate synthetase-fluorodeoxyuridylate ternary complexes.
Topics: Animals; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Folic Acid; Lacticaseibacillus casei; Liver; Methyltransferases; Mice; Protein Binding; Pteroylpolyglutamic Acids; Radioisotope Dilution Technique; Species Specificity; Thymidylate Synthase; Tritium | 1981 |
Sequential methotrexate and 5-fluorouracil: mechanisms of synergy.
Topics: Animals; Biotransformation; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Fluorodeoxyuridylate; Fluorouracil; Folic Acid; Humans; Methotrexate; Mice; Neoplasm Transplantation; Sarcoma, Experimental; Thymidylate Synthase; Time Factors | 1983 |
The effect of derivatives of folic acid on the fluorodeoxyuridylate-thymidylate synthetase covalent complex in human colon xenografts.
Topics: Adenocarcinoma; Animals; Cell Line; Colonic Neoplasms; Deoxyuracil Nucleotides; Female; Fluorodeoxyuridylate; Folic Acid; Homocysteine; Humans; Methyltransferases; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Rectal Neoplasms; Tetrahydrofolates; Thymidylate Synthase; Transplantation, Heterologous; Vitamin B 12 | 1982 |
Simultaneous measurement of one-carbon and polyglutamate derivatives of folic acid in rat liver using enzymatic interconversions of folates followed by ternary complex formation with thymidylate synthetase and 5-fluorodeoxyuridylic acid: standardization o
Topics: Animals; Carbon; Densitometry; Fluorodeoxyuridylate; Folic Acid; Isoelectric Focusing; Liver; Male; Polyglutamic Acid; Rats; Rats, Wistar; Sensitivity and Specificity; Thymidylate Synthase | 1995 |
Phosphorus-31 nuclear magnetic resonance studies of complexes of thymidylate synthase.
Topics: Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Folic Acid; Magnetic Resonance Spectroscopy; Phosphorus Isotopes; Quinazolines; Tetrahydrofolates; Thymidine Monophosphate; Thymidylate Synthase | 1994 |
Fluorine-19 nuclear magnetic resonance studies of binary and ternary complexes of thymidylate synthase utilizing a fluorine-labeled folate analogue.
Topics: Fluorine; Fluorodeoxyuridylate; Folic Acid; Lacticaseibacillus casei; Macromolecular Substances; Magnetic Resonance Spectroscopy; Protein Binding; Protein Conformation; Protein Denaturation; Quinazolines; Thymidylate Synthase | 1993 |
Effect of folate diastereoisomers on the binding of 5-fluoro-2'-deoxyuridine-5'-monophosphate to thymidylate synthase.
Topics: Fluorodeoxyuridylate; Folic Acid; Stereoisomerism; Substrate Specificity; Thymidylate Synthase | 1993 |
[Changes of the number of FdUMP binding sites of thymidylate synthase and folate pools in human colorectal carcinomas following the administration of tegafur and uracil: preliminary report].
Topics: Antineoplastic Combined Chemotherapy Protocols; Binding Sites; Colorectal Neoplasms; Fluorodeoxyuridylate; Folic Acid; Humans; Tegafur; Thymidylate Synthase; Uracil | 1993 |
Studies of 5-fluorodeoxyuridine 5'-monophosphate binding to carboxypeptidase A-inactivated thymidylate synthase from Lactobacillus casei.
Topics: Binding Sites; Carboxypeptidases; Carboxypeptidases A; Enzymes, Immobilized; Fluorodeoxyuridylate; Folic Acid; Kinetics; Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; Protein Binding; Tetrahydrofolates; Thymidylate Synthase | 1993 |
Trichinella spiralis thymidylate synthase: developmental pattern, isolation, molecular properties, and inhibition by substrate and cofactor analogues.
Topics: Animals; Chromatography, Affinity; Enzyme Inhibitors; Fluorodeoxyuridylate; Folic Acid; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Humans; Kinetics; Larva; Liver; Liver Regeneration; Muscles; Quinazolines; Rats; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase; Trichinella spiralis | 1996 |
Isolation and characterization of thymitaq (AG337) and 5-fluoro-2-deoxyuridylate-resistant mutants of human thymidylate synthase from ethyl methanesulfonate-exposed human sarcoma HT1080 cells.
Topics: Cloning, Molecular; Drug Resistance; Enzyme Inhibitors; Escherichia coli; Ethyl Methanesulfonate; Fluorodeoxyuridylate; Folic Acid; Folic Acid Antagonists; Gene Expression Regulation, Enzymologic; Humans; Kinetics; Mutagenesis; Mutagenesis, Site-Directed; Polymorphism, Single-Stranded Conformational; Quinazolines; Recombinant Proteins; Sarcoma; Thymidylate Synthase; Tumor Cells, Cultured | 1998 |
D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine.
Topics: Asparagine; Aspartic Acid; Binding Sites; Crystallography, X-Ray; Escherichia coli; Fluorodeoxyuridylate; Folic Acid; Hydrogen Bonding; Imidazoles; Macromolecular Substances; Models, Molecular; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Quinazolines; Substrate Specificity; Tetrahydrofolates; Thymidylate Synthase | 1998 |
Targeted drug delivery to chemoresistant cells: folic acid derivatization of FdUMP[10] enhances cytotoxicity toward 5-FU-resistant human colorectal tumor cells.
Topics: Antineoplastic Agents; Carrier Proteins; Colorectal Neoplasms; Drug Delivery Systems; Drug Resistance, Neoplasm; Fluorodeoxyuridylate; Fluorouracil; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Membrane Proteins; Membrane Transport Proteins; Receptors, Cell Surface; RNA, Messenger; Thymidylate Synthase; Tumor Cells, Cultured | 2001 |
Probing electrostatic channeling in protozoal bifunctional thymidylate synthase-dihydrofolate reductase using site-directed mutagenesis.
Topics: Animals; Binding Sites; Catalysis; Crystallization; Enzyme Stability; Fluorodeoxyuridylate; Folic Acid; Hydrocarbons; Kinetics; Leishmania major; Methane; Models, Molecular; Molecular Structure; Multienzyme Complexes; Mutagenesis, Site-Directed; NADP; Quinazolines; Spectrophotometry; Static Electricity; Structure-Activity Relationship; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thymidylate Synthase | 2003 |