Page last updated: 2024-08-18

fluorodeoxyuridylate and fluorouracil

fluorodeoxyuridylate has been researched along with fluorouracil in 132 studies

Research

Studies (132)

Timeframe	Studies, this research(%)	All Research%
pre-1990	62 (46.97)	18.7374
1990's	45 (34.09)	18.2507
2000's	16 (12.12)	29.6817
2010's	6 (4.55)	24.3611
2020's	3 (2.27)	2.80

Authors

Authors	Studies
Balzarini, J; Bentrude, WG; Béres, J; De Clercq, E; Kálmán, A; Párkányi, L	1
Balzarini, J; Gonczy, B; Liekens, S; McGuigan, C; Murziani, P; Slusarczyk, M; Vande Voorde, J	1
Benedetti, P; Carosati, E; Costi, MP; Cruciani, G; Farina, D; Ferrari, S; Finer-Moore, J; Guaitoli, G; Luciani, R; Marverti, G; Stroud, RM; Tochowicz, A	1
Chabner, BA; Donehower, RC; Myers, CE	1
Heidelberger, C; Moran, RG; Spears, CP	1
Danhauser, L; Rustum, YM; Wang, G	1
Santi, DV; Washtien, WL	1
Fernandes, DJ; Klubes, P; Mandel, HG	1
Ardalan, B; Cooney, D; Macdonald, JS; Schein, PS	1
Heidelberger, C; Moran, RG	1
Fernandes, DJ; Klubes, P	1
Anderson, T; Chabner, BA; Murinson, DS; Myers, CE; Schwartz, HS	1
Cerna, I; Connelly, K; Klubes, P; Mandel, HG	1
Cerna, I; Connelly, K; Geelhoed, GW; Klubes, P; Mandel, HG	1
Ardalan, B; Buscaglia, MD; Schein, PS	1
Chabner, BA; Myers, CE; Young, RC	1
Harrap, KR; Jackson, RC	1
Fujiwara, Y; Nishio, K; Ohe, Y; Ohmori, T; Saijo, N; Sugimoto, Y	1
Chen, TL; Erlichman, C	1
Hoshi, A; Iigo, M; Nishikata, K	1
Homma, T; Iijima, S; Kido, Y; Mori, T; Sakaue, M; Shiozaki, H; Tsujinaka, T	1
Hoshi, A; Iigo, M; Nakajima, Y	1
Harstrick, A; Rustum, YM; Zhang, ZG	1
Barberi-Heyob, M; Merlin, JL; Webér, B	1
Sasaki, T	1
Akiyoshi, T; Matsuoka, H; Sugimachi, K; Ueo, H	1
Allegra, CJ; Drake, JC; Johnston, PG; Trepel, J	1
Griffiths, JR; Maxwell, RJ; McSheehy, PM	1
Allegra, CJ; Boarman, D; Chu, E; Zinn, S	1
Laurensse, EJ; Peters, GJ; Pinedo, HM; van Groeningen, CJ	1
Weckbecker, G	1
Cloos, J; Marinelli, A; Peters, GJ; Pinedo, HM; Smid, K; Van der Wilt, CL	1
Fujita, H; Hori, T; Mikami, H; Miyata, S; Tai, M	1
Hasegawa, K; Ikeuchi, T; Kai, Y; Onodera, Y; Sasaki, H; Ueno, M; Yoshikawa, H	1
Frösing, R; Gustavsson, BG; Spears, CP	1
Morgan, RG	1
Dreyfuss, A; el-Magharbel, I; Frei, E; Holden, SA; Jones, SM; Rosowsky, A; Trites, D; Wright, JE	1
Griffiths, JR; McSheehy, PM; Prior, MJ	1
Farquhar, D; Freed, JJ; Hampton, A	1
Fischer, PH; Grem, JL	1
Almersjö, O; Berne, M; Gustavsson, B; Spears, P; Sundström, E	1
Keyomarsi, K; Moran, RG; Patel, R	1
Houghton, JA; Houghton, PJ; Torrance, PM; Weiss, KD; Williams, LG	1
Ivanetich, KM; Santi, DV	1
Berne, M; Bernstein, L; Frösing, R; Gustavsson, BG; Hayes, AA; Spears, CP	1
Kashani-Sabet, M; Lu, Y; Ma, J; Newman, E; Scanlon, KJ	1
Carlsson, G; Frösing, R; Gustavsson, BG; Spears, CP	1
Lu, Y; Newman, EM; Priest, DG; Scanlon, KJ	1
Day, JL; Sadee, W	1
Allegra, CJ; Bagley, C; Chabner, BA; Drake, JC; Lippman, ME; Sholar, PW	1
Carpinelli, G; Cassone, A; Di Vito, M; Kerridge, D; Podo, F; Torosantucci, A; Whelan, WL	1
Houghton, JA; Houghton, PJ; Radparvar, S; Torrance, PM; Williams, LG	1
Almersjö, O; Berne, M; Gustavsson, B; Spears, CP; Waldenström, J	1
Almersjö, O; Berne, MH; Frösing, R; Gustavsson, BG; Spears, PC	1
Brooks, M; Cadman, E; Tseng, A	1
Goulian, M; Ingraham, HA; Tseng, BY	1
Myers, CE	1
Corbett, TH; Heidelberger, C; Moran, RG; Shahinian, AH; Spears, CP	1
Bertino, JR; Fernandes, DJ; Moroson, BA	1
Fox, RM; Piper, AA	1
Mandel, HG	1
Au, JL; Luccioni, CM; Rustum, YM; Wientjes, MG	1
Cadman, E; Grant, S	1
Ardalan, B; Cooney, D; Lippman, M; Macdonald, J; Schein, P	2
Kimura, K; Tanaka, M; Yoshida, S	1
Bailey, BD; Bowen, D; Guernsey, LA	1
Farquhar, D; Kuttesch, NJ; Wilkerson, MG; Winkler, T	1
Houghton, JA; Houghton, PJ	1
Lankelma, J; Laurensse, E; Leyva, A; Peters, GJ; Pinedo, HM	1
Berger, SH; Hakala, MT	1
Washtien, WL	1
Chabner, BA; Donehower, RC; Liang, CM	1
Bertino, JR; Fernandes, DJ; Mini, E	1
Santi, DV	1
Morris, HP; Sonidis, GP; Tryfiates, GP	1
Au, JL; Danhauser, L; Luccioni, C; Rustum, YM	1
Morin, J; Wolberg, WH	1
Tamemasa, O; Tezuka, M	1
Heidelberger, C	1
Houghton, JA; Houghton, PJ; Maroda, SJ; Phillips, JO	1
Galandiuk, S; Myers, SR; Wrightson, WR	1
Peters, GJ; Rustum, YM; Smid, K; van der Wilt, CL; van Laar, JA	1
Peters, GJ; Pinedo, HM; Telleman, F; van der Wilt, CL; van Triest, B	1
Braakhuis, BJ; De Jong, M; Peters, GJ; Pinedo, HM; Smid, K; Van der Wilt, CL	1
Meijer, S; Peters, GJ; Pinedo, HM; Smid, K; van der Wilt, CL; van Groeningen, CJ	1
Baptiste, N; O'Connor, CJ; Otter, BA; Schwartz, EL; Wadler, S	1
Allegra, CJ; Chu, E	1
Hidaka, K; Hisatsugu, T; Kohno, K; Komiyama, S; Kuwano, M; Sato, S	1
Hoekman, K; Meijer, S; Peters, GJ; Pinedo, HM; Smid, K; van der Wilt, CL; van Groeningen, CJ	1
Allegra, CJ; Drake, JC; Johnston, PG	1
Allegra, CJ; Anderson, L; Chu, E; Strong, JM; Takimoto, CH; Voeller, DB	1
Taguchi, T	1
Kok, RM; Lankelma, J; Meyer, S; Noordhuis, P; Peters, GJ; Pinedo, HM; van der Wilt, CL; van Groeningen, CJ	1
Carlsson, G; Gustavsson, BG; Jaresko, G; Muggia, FM; Spears, CP	1
Hatano, H; Naomoto, Y; Orita, K; Tanaka, N	1
Herscheid, JD; Peters, GJ; van der Wilt, CL; Visser, GW; Wedzinga, R	1
Kumada, K; Nakamura, T; Nakano, H; Namatame, K; Sakai, H; Suzuki, T; Takahashi, H	1
Kuiper, CM; Peters, GJ; Pinedo, HM; Rustum, YM; Smid, K; Van der Wilt, CL; Van Laar, JA	1
Aherne, GW; Allegra, CJ; Geoffroy, F; Grem, JL; Hardcastle, A; Johnston, PG; Ren, Q; Van Groeningen, CJ	1
Jansen, G; Peters, GJ; Pinedo, HM; Telleman, F; van der Wilt, CL; van Triest, B	1
Ghoshal, K; Jacob, ST	1
Bretner, M; Dzik, JM; Felczak, K; Gołos, B; Kulikowski, T; Rode, W; Shugar, D	1
Noordhuis, P; Peters, GJ; Pinedo, HM; Rustum, YM; Smid, K; van der Wilt, CL; van Laar, JA	1
Jansen, G; Noordhuis, P; Peters, GJ; Pinedo, HM; Schoenmakers, PS; Smid, K; Telleman, F; van der Wilt, CL; van Hensbergen, Y; van Laar, JA; van Triest, B	1
Anderson, J; Gmeiner, WH; Kolar, C; Kolath, J; Lawson, T; Liu, J; Skradis, A; Talmadge, J	1
Barbour, KW; Berger, FG; Forsthoefel, AM; Kitchens, ME; Spencer, HT	1
Anderson, J; Gmeiner, WH; Kolar, C; Kolath, J; Lawson, TA; Liu, J; Talmadge, J	1
Erdélyi-Tóth, V; Jeney, A; Katona, C; Kovács, P; Kralovánszky, J; Noordhuis, P; Otvös, L; Pandi, E; Peters, GJ; Van der Wilt, CL	1
Hironaga, K; Kawaguchi, Y; Nagayama, S; Yamaguchi, S; Yamamoto, A; Yoshisue, K	1
Ariki, N; Funaki, M; Gouchi, A; Iwagaki, H; Morimoto, Y; Shimamura, H; Tanaka, N	1
Aebi, S; Friess, H; Liu, S; Procházková, A; Thormann, W	1
Gmeiner, WH; Kolar, C; Lawson, TA; Liu, J	1
Griffiths, JR; Howe, FA; Lofts, F; McIntyre, DJ; McSheehy, PM; Nicholson, G; Noordhuis, P; Peters, GJ; Price, NM; Rodrigues, LM; Smid, K; Stubbs, M; Wadsworth, P	1
Egawa, S; Fukuyama, S; Hamada, H; Matsuno, S; Motoi, F; Oonuma, M; Shibuya, K; Shimamura, H; Sunamura, M; Takeda, K; Yamauchi, J	1
Ayabe, H; Fukushima, M; Haseba, M; Hidaka, S; Nakagoe, T; Sawai, T; Tagawa, Y; Tsuji, T; Yamaguchi, H; Yano, H; Yasutake, T	1
Heerschap, A; Hull, WE; Kamm, YJ; Peters, GJ; Punt, CJ	1
Gmeiner, WH; Trump, E; Wei, C	1
Chen, M; Chenevert, TL; Dornfeld, KJ; Gelovani, JT; Hamstra, DA; Lawrence, TS; Lee, KC; Moffat, BA; Rehemtulla, A; Ross, BD; Schepkin, VD; Tychewicz, JM	1
Antony, S; Gmeiner, WH; Kohlhagen, G; Liao, ZY; Pommier, Y; Sordet, O; Zhang, HL	1
Achiwa, H; Bessho, Y; Maeda, H; Maeno, K; Oguri, T; Ozasa, H; Sato, S; Ueda, R	1
Bijnsdorp, IV; Comijn, EM; Gmeiner, WH; Padron, JM; Peters, GJ	1
de Carvalho, AI; Gomes, J; Günther Sillero, MA; Martins, S; Pérez-Zúñiga, F; Sillero, A; Silles, E	1
Chies, JA; Escargueil, AE; Garcia-Santos, D; Grivicich, I; Henriques, JA; Larsen, AK; Matuo, R; Saffi, J; Sousa, FG	1
Carli, D; Cohen, S; Dumontet, C; Guitton, J; Honorat, M; Megherbi, M; Payen, L; Vignal, B	1
Akiyama, S; Che, XF; Furukawa, T; Ikeda, R; Kanekura, T; Kanzaki, T; Mataki, H; Matsushita, S; Minami, K; Miyadera, K; Nishizawa, Y; Tabata, S; Tajitsu, Y; Takeda, Y; Ushiyama, M; Yamada, K; Yamamoto, M	1
Gmeiner, WH; Pommier, Y; Reinhold, WC	1
Furuya, A; Hiwasa, T; Koide, N; Matsubara, H; Nabeya, Y; Ochiai, T; Ohkoshi, M; Suzuki, T; Takiguchi, M	1
Beijnen, JH; Derissen, EJ; Hillebrand, MJ; Rosing, H; Schellens, JH	1
Guo, J; Huang, L; Liu, Y; Sun, D; Yu, Z; Zou, Y	1
Guo, J; Huang, L	1
Bré, J; Czekster, CM; Dickson, AL; Harrison, DJ; McKissock, FG; Mullen, P; Read, OJ; Tang, P; Zhang, Y; Zickuhr, GM	1

Reviews

12 review(s) available for fluorodeoxyuridylate and fluorouracil

Article	Year
[High-dose leucovorin and 5-FU]. Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:7 Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Evaluation; Fluorodeoxyuridylate; Fluorouracil; Humans; Leucovorin; Stomach Neoplasms; Thymidylate Synthase	1992
Biochemical pharmacology and analysis of fluoropyrimidines alone and in combination with modulators. Pharmacology & therapeutics, 1991, Volume: 50, Issue:3 Topics: Animals; Fluorodeoxyuridylate; Fluorouracil; Humans; Neoplasms; Neoplasms, Experimental; Pyrimidines; RNA; Thymidylate Synthase	1991
Leucovorin enhancement of the effects of the fluoropyrimidines on thymidylate synthase. Cancer, 1989, Mar-15, Volume: 63, Issue:6 Suppl Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Synergism; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Leucovorin; Neoplasms; Thymidylate Synthase	1989
The pharmacology of the fluoropyrimidines. Pharmacological reviews, 1981, Volume: 33, Issue:1 Topics: Animals; Chemical Phenomena; Chemistry; Deoxyuracil Nucleotides; Flucytosine; Fluorodeoxyuridylate; Fluorouracil; Fungi; Humans; Kinetics; RNA; Thymidine; Thymidylate Synthase	1981
The target cell determinants of the antitumor actions of 5-FU: does FU incorporation into RNA play a role? Cancer treatment reports, 1981, Volume: 65 Suppl 3 Topics: Animals; DNA, Bacterial; DNA, Neoplasm; Fluorodeoxyuridylate; Fluorouracil; Mice; Neoplasms, Experimental; RNA, Bacterial; RNA, Neoplasm; Thymidine	1981
Perspective on the design and biochemical pharmacology of inhibitors of thymidylate synthetase. Journal of medicinal chemistry, 1980, Volume: 23, Issue:2 Topics: Antineoplastic Agents; Deoxyuracil Nucleotides; Deoxyuridine; Fluorodeoxyuridylate; Fluorouracil; Methotrexate; Methyltransferases; Protein Binding; Structure-Activity Relationship; Thymidylate Synthase; Uracil	1980
Vitamin B6 and cancer (review). Anticancer research, 1981, Volume: 1, Issue:5 Topics: Animals; Biotransformation; Cell Division; Fluorodeoxyuridylate; Fluorouracil; Liver Neoplasms, Experimental; Penicillamine; Pyridoxal Phosphate; Pyridoxine; Rats; Thymidylate Synthase	1981
Determinants of response to antimetabolites and their modulation by normal purine and pyrimidine metabolites. Cancer treatment reports, 1981, Volume: 65 Suppl 3 Topics: Animals; Antimetabolites, Antineoplastic; Cytarabine; DNA, Neoplasm; Fluorodeoxyuridylate; Fluorouracil; Humans; Leukemia L1210; Neoplasms; Neoplasms, Experimental; Thymidine; Thymidylate Synthase; Uridine	1981
[Development of fluorinated pyrimidines in Japan]. Gan to kagaku ryoho. Cancer & chemotherapy, 1993, Volume: 20, Issue:1 Topics: Animals; Antineoplastic Agents; Clinical Trials as Topic; Deoxycytidine; Drug Combinations; Fluorodeoxyuridylate; Fluorouracil; Humans; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Neoplasms; Neoplasms, Experimental; Oxonic Acid; Pyridines; Rats; Tegafur	1993
Aspects of one-carbon folate cycling related to fluoropyrimidine and antifolate therapy. Cancer treatment and research, 1995, Volume: 78 Topics: Animals; Antimetabolites, Antineoplastic; Fluorodeoxyuridylate; Fluorouracil; Folic Acid; Folic Acid Antagonists; Glycine Hydroxymethyltransferase; Humans; Leucovorin; Neoplasms	1995
An alternative molecular mechanism of action of 5-fluorouracil, a potent anticancer drug. Biochemical pharmacology, 1997, Jun-01, Volume: 53, Issue:11 Topics: Animals; Antimetabolites, Antineoplastic; Endoribonucleases; Fluorodeoxyuridylate; Fluorouracil; Mice; Protein Biosynthesis; RNA Precursors; RNA Splicing; RNA-Binding Proteins; RNA, Small Nuclear; Tumor Cells, Cultured	1997
Formulation of two lipid-based membrane-core nanoparticles for FOLFOX combination therapy. Nature protocols, 2022, Volume: 17, Issue:8 Topics: Animals; Carcinoma, Hepatocellular; Colorectal Neoplasms; Fluorodeoxyuridylate; Fluorouracil; Lipids; Liposomes; Liver Neoplasms; Nanoparticles; Oxaliplatin; Polyethylene Glycols	2022

Trials

3 trial(s) available for fluorodeoxyuridylate and fluorouracil

Article	Year
Schedule-dependent inhibition of thymidylate synthase by 5-fluorouracil in gastric cancer. Cancer, 1992, Dec-15, Volume: 70, Issue:12 Topics: Aged; Animals; Combined Modality Therapy; DNA, Neoplasm; Drug Administration Schedule; Drug Stability; Fluorodeoxyuridylate; Fluorouracil; Gastric Mucosa; Humans; Kinetics; Lymph Nodes; Mice; Middle Aged; Neoplasm Transplantation; Ploidies; Sarcoma 180; Stomach Neoplasms; Thymidylate Synthase	1992
Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: implications for treatment with fluorouracil. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1994, Volume: 12, Issue:10 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Female; Fluorodeoxyuridylate; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Remission Induction; Thymidylate Synthase	1994
Histopathological response to preoperative chemotherapy including 5-fluorouracil additionally assessed by immunocytochemical and pharmacologic parameters in patients with advanced gastric cancer. Surgery today, 1996, Volume: 26, Issue:7 Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bromodeoxyuridine; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Fluorodeoxyuridylate; Fluorouracil; Humans; Immunohistochemistry; Injections, Intravenous; Preoperative Care; Proliferating Cell Nuclear Antigen; Stomach Neoplasms; Thymidylate Synthase; Tritium	1996

Other Studies

117 other study(ies) available for fluorodeoxyuridylate and fluorouracil

Article	Year
Synthesis, structure, and antitumor and antiviral activities of a series of 5-halouridine cyclic 3',5'-monophosphates. Journal of medicinal chemistry, 1986, Volume: 29, Issue:4 Topics: Animals; Antineoplastic Agents; Antiviral Agents; Humans; Leukemia L1210; Mice; Molecular Conformation; Nucleotides, Cyclic; Protein Kinases; Rabbits; Simplexvirus; Structure-Activity Relationship; Uracil Nucleotides; Uridine Monophosphate; Vaccinia virus; X-Ray Diffraction	1986
Phosphoramidate ProTides of the anticancer agent FUDR successfully deliver the preformed bioactive monophosphate in cells and confer advantage over the parent nucleoside. Journal of medicinal chemistry, 2011, Oct-27, Volume: 54, Issue:20 Topics: Antineoplastic Agents; Cell Culture Techniques; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Equilibrative Nucleoside Transporter 1; Floxuridine; Humans; Mycoplasma hyorhinis; Organophosphorus Compounds; Prodrugs; Pyrimidine Phosphorylases; Structure-Activity Relationship	2011
Inhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase. Journal of medicinal chemistry, 2012, Nov-26, Volume: 55, Issue:22 Topics: Acetanilides; Antineoplastic Agents; Cisplatin; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Female; High-Throughput Screening Assays; Humans; Models, Molecular; Molecular Structure; Ovarian Neoplasms; Structure-Activity Relationship; Thiazoles; Thymidylate Synthase; Tumor Cells, Cultured	2012
New developments on the mechanisms of action of antineoplastic drugs. Life sciences, 1979, Jul-02, Volume: 25, Issue:1 Topics: Antineoplastic Agents; Bleomycin; Doxorubicin; Drug Interactions; Drug Synergism; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Methotrexate	1979
Biochemical determinants of tumor sensitivity to 5-fluorouracil: ultrasensitive methods for the determination of 5-fluoro-2'-deoxyuridylate, 2'-deoxyuridylate, and thymidylate synthetase. Proceedings of the National Academy of Sciences of the United States of America, 1979, Volume: 76, Issue:3 Topics: Cell Line; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Fluorouracil; Humans; Lacticaseibacillus casei; Methyltransferases; Neoplasms; Radioligand Assay; Thymidylate Synthase	1979
Selectivity of action of 5-FU: biochemical basis. Bulletin du cancer, 1979, Volume: 66, Issue:1 Topics: Animals; Colonic Neoplasms; Drug Resistance; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Leukemia L1210; Mice; Mice, Inbred Strains; Rats; RNA, Neoplasm; Thymidine; Uridine	1979
Assay of intracellular free and macromolecular-bound metabolites of 5-fluorodeoxyuridine and 5-fluorouracil. Cancer research, 1979, Volume: 39, Issue:9 Topics: Animals; Chromatography, Gel; Culture Techniques; Cytosol; Deoxyuracil Nucleotides; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Kinetics; Leukemia L1210; Rats; RNA; Thymidine Kinase	1979
Studies of the antitumor action of 5-fluorouracil (FU). Bulletin du cancer, 1979, Volume: 66, Issue:1 Topics: Animals; Antineoplastic Agents; Bone Marrow; Carcinoma 256, Walker; Colonic Neoplasms; Deoxyuridine; DNA; Drug Resistance; Fluorodeoxyuridylate; Fluorouracil; Humans; Intestine, Small; Leukemia L1210; Mice; Rats; Ribosomes	1979
Studies on mechanisms of 5-fluorouracil resistance in murine and human tumors. Bulletin du cancer, 1979, Volume: 66, Issue:1 Topics: Adenocarcinoma; Animals; Breast Neoplasms; Drug Resistance; Fluorodeoxyuridylate; Fluorouracil; Humans; In Vitro Techniques; Mice; Neoplasms; Neoplasms, Experimental; Phosphorylation; Uracil Nucleotides	1979
Determinants of 5-fluorouracil sensitivity in human tumors. Bulletin du cancer, 1979, Volume: 66, Issue:1 Topics: Biopsy, Needle; Breast Neoplasms; Colonic Neoplasms; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Fluorouracil; Humans; Thymidylate Synthase	1979
A biochemical and pharmacological study of therapeutic synergism with 5-fluorouracil plus cyclophosphamide in murine L1210 leukemia. Cancer research, 1979, Volume: 39, Issue:4 Topics: Animals; Body Weight; Bone Marrow; Cyclophosphamide; DNA, Neoplasm; Drug Synergism; Drug Therapy, Combination; Fluorodeoxyuridylate; Fluorouracil; Leukemia L1210; Male; Mice; Mice, Inbred Strains	1979
Competitive binding radioassay for 5-fluorodeoxyuridine 5'-monophosphate in tissues. Cancer research, 1979, Volume: 39, Issue:7 Pt 1 Topics: Animals; Binding, Competitive; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Fluorouracil; Half-Life; Leukemia L1210; Mice; Radioligand Assay; Thymidylate Synthase	1979
Effects of 5-fluorouracil on 5-fluorodeoxyuridine 5'-monophosphate and 2-deoxyuridine 5'-monophosphate pools, and DNA synthesis in solid mouse L1210 and rat Walker 256 tumors. Cancer research, 1978, Volume: 38, Issue:8 Topics: Animals; Bone Marrow; Carcinoma 256, Walker; Deoxyuracil Nucleotides; Deoxyuridine; DNA, Neoplasm; Drug Resistance; Fluorodeoxyuridylate; Fluorouracil; Intestine, Small; Leukemia L1210; Male; Mice; Mice, Inbred Strains; Rats	1978
Effects of 5-fluorouracil on human colon carcinoma and solid rat Walker 256 carcinosarcoma: evaluation as in vitro predictors of clinical response. Cancer treatment reports, 1978, Volume: 62, Issue:7 Topics: Animals; Carcinoma 256, Walker; Colonic Neoplasms; Deoxyuridine; DNA, Neoplasm; Fluorodeoxyuridylate; Fluorouracil; Humans; In Vitro Techniques; Mice; Ribosomes	1978
Tumor 5-fluorodeoxyuridylate concentration as a determinant of 5-fluorouracil response. Biochemical pharmacology, 1978, Volume: 27, Issue:16 Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Deoxyuracil Nucleotides; DNA, Neoplasm; Fluorodeoxyuridylate; Fluorouracil; Kinetics; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasms, Experimental	1978
Biochemical determinants of 5-fluorouracil response in vivo. The role of deoxyuridylate pool expansion. The Journal of clinical investigation, 1975, Volume: 56, Issue:5 Topics: Animals; Binding Sites; Binding, Competitive; DNA, Neoplasm; Fluorodeoxyuridylate; Fluorouracil; Methyltransferases; Mice; Neoplasms, Experimental; Thymidylate Synthase; Uracil Nucleotides	1975
Enzyme kinetics and combination chemotherapy: an appraisal of current concepts. Advances in enzyme regulation, 1975, Volume: 13 Topics: Antimetabolites; Cell Line; Cell-Free System; Cells, Cultured; Drug Therapy, Combination; Enzyme Inhibitors; Enzymes; Fluorodeoxyuridylate; Fluorouracil; Folic Acid Antagonists; Kinetics; Macromolecular Substances; Methotrexate; Models, Biological	1975
In vitro enhancement of fluoropyrimidine-induced cytotoxicity by leucovorin in colorectal and gastric carcinoma cell lines but not in non-small-cell lung carcinoma cell lines. Cancer chemotherapy and pharmacology, 1992, Volume: 30, Issue:6 Topics: Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Cell Survival; Colony-Forming Units Assay; Colorectal Neoplasms; Drug Synergism; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Leucovorin; Lung Neoplasms; Stomach Neoplasms; Tetrahydrofolates; Thymidylate Synthase; Tumor Cells, Cultured	1992
Biochemical modulation of 5-fluorouracil with or without leucovorin by a low dose of brequinar in MGH-U1 cells. Cancer chemotherapy and pharmacology, 1992, Volume: 30, Issue:5 Topics: Antineoplastic Combined Chemotherapy Protocols; Biphenyl Compounds; Cell Survival; Cytidine Triphosphate; Deoxyuracil Nucleotides; Dose-Response Relationship, Drug; Drug Interactions; Fluorodeoxyuridylate; Fluorouracil; Humans; Hypoxanthine; Hypoxanthines; Leucovorin; Phosphoribosyl Pyrophosphate; Thymidylate Synthase; Tumor Cells, Cultured; Uridine Triphosphate	1992
In vivo antitumor effects of fluoropyrimidines on colon adenocarcinoma 38 and enhancement by leucovorin. Japanese journal of cancer research : Gann, 1992, Volume: 83, Issue:4 Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Cell Division; Colonic Neoplasms; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Leucovorin; Male; Mice; Mice, Inbred Strains; Thymidylate Synthase; Uridine	1992
Antitumor effect and tumor level of 5-fluoro-2'-deoxyuridylate following oral administration of tetradecyl 2'-deoxy-5-fluoro-5'-uridylate. Anti-cancer drugs, 1992, Volume: 3, Issue:3 Topics: Adenocarcinoma; Administration, Oral; Animals; Antineoplastic Agents; Colonic Neoplasms; Fluorodeoxyuridylate; Fluorouracil; Injections, Intravenous; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Mice, Nude; Neoplasms, Experimental	1992
Mechanisms of resistance to fluoropyrimidines. Seminars in oncology, 1992, Volume: 19, Issue:2 Suppl 3 Topics: Cecal Neoplasms; Deoxyuracil Nucleotides; Drug Resistance; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Ileal Neoplasms; Leucovorin; Tetrahydrofolates; Thymidylate Synthase; Tumor Cells, Cultured	1992
Determination of 5-fluorouracil and its main metabolites in plasma by high-performance liquid chromatography. Journal of chromatography, 1992, Jan-17, Volume: 573, Issue:2 Topics: Chromatography, High Pressure Liquid; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Hydrogen-Ion Concentration; Phosphates; Potassium; Potassium Compounds; Spectrophotometry, Ultraviolet; Uridine	1992
Preliminary evidence that incorporation of 5-fluorouracil into RNA correlates with antitumor response. Cancer investigation, 1992, Volume: 10, Issue:4 Topics: Colonic Neoplasms; Fluorodeoxyuridylate; Fluorouracil; Humans; Liver Neoplasms; Rectal Neoplasms; Remission Induction; RNA, Neoplasm; Stomach Neoplasms	1992
Immunological quantitation of thymidylate synthase using the monoclonal antibody TS 106 in 5-fluorouracil-sensitive and -resistant human cancer cell lines. Cancer research, 1992, Aug-15, Volume: 52, Issue:16 Topics: Antibodies, Monoclonal; Antibody Specificity; Blotting, Western; Breast Neoplasms; Colonic Neoplasms; Doxorubicin; Drug Resistance; Fluorescent Antibody Technique; Fluorodeoxyuridylate; Fluorouracil; Humans; Molecular Weight; Stomach Neoplasms; Thymidylate Synthase; Tumor Cells, Cultured	1992
Detection of differential sensitivity to 5-fluorouracil in Ehrlich ascites tumour cells by 19F NMR spectroscopy. NMR in biomedicine, 1991, Volume: 4, Issue:6 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Carcinoma, Ehrlich Tumor; Cell Extracts; Chromatography, High Pressure Liquid; Fluorodeoxyuridylate; Fluorouracil; Magnetic Resonance Spectroscopy; Phosphorus; Protons; Tumor Cells, Cultured; Uracil Nucleotides; Uridine Diphosphate Glucose; Uridine Triphosphate	1991
Interaction of gamma interferon and 5-fluorouracil in the H630 human colon carcinoma cell line. Cancer research, 1990, Sep-15, Volume: 50, Issue:18 Topics: Adenocarcinoma; Cell Division; Colonic Neoplasms; DNA; Drug Interactions; Drug Resistance; Fluorodeoxyuridylate; Fluorouracil; Folic Acid; Humans; Interferon-gamma; RNA; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Tumor Cells, Cultured	1990
A comparison of 5-fluorouracil metabolism in human colorectal cancer and colon mucosa. Cancer, 1991, Nov-01, Volume: 68, Issue:9 Topics: Adenosine Triphosphate; Aged; Aged, 80 and over; Colon; Colonic Neoplasms; Fluorodeoxyuridylate; Fluorouracil; Humans; Intestinal Mucosa; Middle Aged; Orotate Phosphoribosyltransferase; Pentosyltransferases; Phosphoribosyl Pyrophosphate; Pyrimidine Phosphorylases; Rectal Neoplasms; Ribosemonophosphates; Uracil Nucleotides; Uridine Triphosphate	1991
Isolated liver perfusion versus hepatic artery infusion with 5-fluorouracil in a rat model; effects on thymidylate synthase. Advances in experimental medicine and biology, 1991, Volume: 309A Topics: Animals; Binding Sites; Bone Marrow; Cell Line; Colonic Neoplasms; Fluorodeoxyuridylate; Fluorouracil; Infusions, Intra-Arterial; Liver; Liver Neoplasms; Perfusion; Rats; Thymidylate Synthase	1991
Competitive binding radioassay for the determination of 5-fluorodeoxyuridine and 5-fluorodeoxyuridine-5'-monophosphate levels in plasma and tumor tissue. Japanese journal of cancer research : Gann, 1991, Volume: 82, Issue:6 Topics: Animals; Carcinoma, Ehrlich Tumor; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Kinetics; Lacticaseibacillus casei; Mice; Mice, Inbred Strains; Radioligand Assay; Thymidine Kinase; Thymidylate Synthase; Tritium	1991
[Single drug chemotherapy with 5-FU oral administration of bladder cancer]. Gan to kagaku ryoho. Cancer & chemotherapy, 1990, Volume: 17, Issue:10 Topics: Administration, Oral; Carcinoma, Transitional Cell; Fluorodeoxyuridylate; Fluorouracil; Humans; Male; Middle Aged; Remission Induction; Thymidylate Synthase; Tissue Distribution; Urinary Bladder Neoplasms	1990
Folinic acid modulation of fluorouracil: tissue kinetics of bolus administration. Investigational new drugs, 1989, Volume: 7, Issue:1 Topics: Aged; Biotransformation; Colonic Neoplasms; Cytosol; Drug Interactions; Female; Fluorodeoxyuridylate; Fluorouracil; Humans; Lacticaseibacillus casei; Leucovorin; Male; Middle Aged; Thymidylate Synthase	1989
Selective expansion of 5,10-methylenetetrahydrofolate pools and modulation of 5-fluorouracil antitumor activity by leucovorin in vivo. Cancer research, 1989, May-15, Volume: 49, Issue:10 Topics: Animals; Female; Fluorodeoxyuridylate; Fluorouracil; Leucovorin; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Tetrahydrofolates	1989
Prediction of 5-fluorouracil cytotoxicity towards the Walker carcinosarcoma using peak integrals of fluoronucleotides measured by MRS in vivo. British journal of cancer, 1989, Volume: 60, Issue:3 Topics: Animals; Carcinoma 256, Walker; Deoxyuracil Nucleotides; Female; Fluorodeoxyuridylate; Fluorouracil; Magnetic Resonance Spectroscopy; Rats; Rats, Inbred Strains; Uridine Triphosphate	1989
Evidence for acyloxymethyl esters of pyrimidine 5'-deoxyribonucleotides as extracellular sources of active 5'-deoxyribonucleotides in cultured cells. Biochemical pharmacology, 1989, Oct-01, Volume: 38, Issue:19 Topics: Animals; Blood Physiological Phenomena; Cells, Cultured; Deoxyuracil Nucleotides; Deoxyuridine; DNA; Esters; Fluorodeoxyuridylate; Fluorouracil; Mice; Thymidine; Thymidine Monophosphate	1989
Alteration of fluorouracil metabolism in human colon cancer cells by dipyridamole with a selective increase in fluorodeoxyuridine monophosphate levels. Cancer research, 1986, Volume: 46, Issue:12 Pt 1 Topics: Cells, Cultured; Colonic Neoplasms; Deoxyuracil Nucleotides; Deoxyuridine; Dipyridamole; DNA; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Ribonucleotides; Time Factors; Uridine Triphosphate	1986
Inhibition of thymidylate synthase after administration of doxifluridine in a transplantable colon carcinoma in the rat. Cancer investigation, 1988, Volume: 6, Issue:4 Topics: Animals; Carcinoma; Colonic Neoplasms; Female; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Male; Neoplasm Transplantation; Rats; Rats, Inbred Strains; Thymidylate Synthase	1988
Tumor cell responses to inhibition of thymidylate synthase. Advances in experimental medicine and biology, 1988, Volume: 244 Topics: Animals; Cell Line; Cell Survival; Drug Screening Assays, Antitumor; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Kinetics; Leucovorin; Protein Binding; Thymidylate Synthase; Tumor Cells, Cultured	1988
Relationship between 5-fluoro-2'-deoxyuridylate, 2'-deoxyuridylate, and thymidylate synthase activity subsequent to 5-fluorouracil administration, in xenografts of human colon adenocarcinomas. Biochemical pharmacology, 1986, Apr-15, Volume: 35, Issue:8 Topics: Adenocarcinoma; Adenosine Monophosphate; Animals; Cell Line; Colonic Neoplasms; Deoxyuracil Nucleotides; Drug Resistance; Fluorodeoxyuridylate; Fluorouracil; Humans; Hydrogen-Ion Concentration; Mice; Neoplasm Transplantation; Phosphoric Monoester Hydrolases; Thymidylate Synthase; Transplantation, Heterologous	1986
Thymidylate synthase and fluorouracil. Advances in experimental medicine and biology, 1988, Volume: 244 Topics: Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Fluorouracil; Kinetics; Lacticaseibacillus casei; Models, Theoretical; Protein Binding; Thermodynamics; Thymidylate Synthase; tRNA Methyltransferases	1988
Mechanisms of innate resistance to thymidylate synthase inhibition after 5-fluorouracil. Cancer research, 1988, Oct-15, Volume: 48, Issue:20 Topics: Adenocarcinoma; Breast Neoplasms; Colonic Neoplasms; Deoxyuracil Nucleotides; Drug Resistance; Fluorodeoxyuridylate; Fluorouracil; Humans; Pancreatic Neoplasms; Stomach Neoplasms; Thymidylate Synthase	1988
Mechanisms for cisplatin-FUra synergism and cisplatin resistance in human ovarian carcinoma cells both in vitro and in vivo. Advances in experimental medicine and biology, 1988, Volume: 244 Topics: Antineoplastic Combined Chemotherapy Protocols; Biological Transport; Cell Division; Cell Line; Cell Survival; Cisplatin; Drug Synergism; Female; Fluorodeoxyuridylate; Fluorouracil; Humans; Ovarian Neoplasms; RNA, Neoplasm; Thymidylate Synthase; Tumor Cells, Cultured	1988
Pharmacodynamics of 5-fluorouracil and leucovorin. Advances in experimental medicine and biology, 1988, Volume: 244 Topics: Adenocarcinoma; Animals; Bone Marrow; Colonic Neoplasms; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Fluorouracil; Humans; Intestinal Mucosa; Leucovorin; Liver; Pancreatic Neoplasms; Rats; Rats, Inbred Strains; Rectal Neoplasms; Stomach Neoplasms; Thymidylate Synthase	1988
Biochemical basis for cisplatin and 5-fluorouracil synergism in human ovarian carcinoma cells. Proceedings of the National Academy of Sciences of the United States of America, 1986, Volume: 83, Issue:23 Topics: Carcinoma; Cell Line; Cisplatin; Drug Synergism; Female; Fluorodeoxyuridylate; Fluorouracil; Folic Acid; Humans; Ovarian Neoplasms; Tetrahydrofolates; Thymidine Monophosphate; Thymidylate Synthase	1986
Determination of 5-fluorouridine diphosphate glucose as a metabolite of 5-fluorouracil in mouse T-lymphoma (S-49) cells using high-performance liquid chromatography. Journal of chromatography, 1986, Apr-18, Volume: 356, Issue:3 Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Fluorouracil; Indicators and Reagents; Lymphoma; Mice; T-Lymphocytes; Uridine Diphosphate Glucose; Uridine Diphosphate Sugars	1986
Preliminary results of a phase II trial for the treatment of metastatic breast cancer with 5-fluorouracil and leucovorin. NCI monographs : a publication of the National Cancer Institute, 1987, Issue:5 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Evaluation; Fluorodeoxyuridylate; Fluorouracil; Folic Acid; Humans; Leucovorin; Middle Aged; Neoplasm Metastasis; Thymidylate Synthase	1987
A 19F nuclear magnetic resonance study of uptake and metabolism of 5-fluorocytosine in susceptible and resistant strains of Candida albicans. Antimicrobial agents and chemotherapy, 1986, Volume: 29, Issue:2 Topics: Candida albicans; Cytosine; Cytosine Deaminase; Drug Resistance, Microbial; Flucytosine; Fluorodeoxyuridylate; Fluorouracil; Magnetic Resonance Spectroscopy; Mutation; Nucleoside Deaminases; Pentosyltransferases	1986
Determination of thymidylate synthase activity in colon tumor tissues after treatment with 5-fluorouracil. Biochemical pharmacology, 1987, Apr-15, Volume: 36, Issue:8 Topics: Adenocarcinoma; Charcoal; Colonic Neoplasms; Fluorodeoxyuridylate; Fluorouracil; Humans; Thymidylate Synthase	1987
Concurrent allopurinol and 5-fluorouracil: 5-fluoro-2'-deoxyuridylate formation and thymidylate synthase inhibition in rat colon carcinoma and in regenerating rat liver. Cancer chemotherapy and pharmacology, 1987, Volume: 20, Issue:3 Topics: Adenocarcinoma; Allopurinol; Animals; Colonic Neoplasms; Deoxyuracil Nucleotides; Female; Fluorodeoxyuridylate; Fluorouracil; Liver; Liver Regeneration; Male; Rats; Rats, Inbred Strains; Thymidylate Synthase; Time Factors	1987
Sequential methotrexate/5-FU: FdUMP formation and TS inhibition in a transplantable rodent colon adenocarcinoma. Cancer chemotherapy and pharmacology, 1986, Volume: 16, Issue:3 Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Deoxyuracil Nucleotides; Drug Interactions; Female; Fluorodeoxyuridylate; Fluorouracil; Kinetics; Male; Methotrexate; Neoplasm Transplantation; Rats; Rats, Inbred Strains; Thymidylate Synthase	1986
Modulation of fluoropyrimidine metabolism by chlorpromazine. Biochemical and biophysical research communications, 1986, Jul-31, Volume: 138, Issue:2 Topics: Animals; Carbon Radioisotopes; Cell Line; Cell Survival; Chlorpromazine; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Fluorouracil; Kinetics; Mice; Sarcoma, Experimental; Tritium; Uridine	1986
Mechanism for exclusion of 5-fluorouracil from DNA. Cancer research, 1980, Volume: 40, Issue:4 Topics: Deoxyuracil Nucleotides; DNA; Fluorodeoxyuridylate; Fluorouracil; In Vitro Techniques; N-Glycosyl Hydrolases; Pyrophosphatases; Uracil	1980
In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil-sensitive and -resistant murine colon adenocarcinomas. Cancer research, 1982, Volume: 42, Issue:2 Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Drug Resistance; Fluorodeoxyuridylate; Fluorouracil; Injections, Intraperitoneal; Kinetics; Methyltransferases; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Neoplasms, Experimental; RNA; Thymidylate Synthase; Time Factors	1982
The role of methotrexate and dihydrofolate polyglutamates in the enhancement of fluorouracil action by methotrexate. Cancer treatment reports, 1981, Volume: 65 Suppl 1 Topics: Animals; Cell Line; Cell Survival; Drug Administration Schedule; Drug Therapy, Combination; Fluorodeoxyuridylate; Fluorouracil; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Polyglutamic Acid; Pteroylpolyglutamic Acids; Thymidylate Synthase	1981
Biochemical basis for the differential sensitivity of human T- and B-lymphocyte lines to 5-fluorouracil. Cancer research, 1982, Volume: 42, Issue:9 Topics: B-Lymphocytes; Biotransformation; Cell Line; Fluorodeoxyuridylate; Fluorouracil; Humans; Orotate Phosphoribosyltransferase; Orotic Acid; RNA; T-Lymphocytes; Thymidine Phosphorylase; Uridine; Uridine Phosphorylase; Uridine Triphosphate	1982
Reversed-phase ion-pair high-performance liquid chromatographic assay of 5-fluorouracil, 5'-deoxy-5-fluorouridine, their nucleosides, mono-, di-, and triphosphate nucleotides with a mixture of quaternary ammonium ions. Journal of chromatography, 1982, Mar-12, Volume: 228 Topics: Chromatography, High Pressure Liquid; Deoxyuracil Nucleotides; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Isomerism; Structure-Activity Relationship; Uracil Nucleotides; Uridine	1982
Modulation of 1-beta-D-arabinofuranosylcytosine metabolism and cytotoxicity in L1210 cells by fluoropyrimidine pretreatment. Cancer research, 1982, Volume: 42, Issue:9 Topics: Animals; Arabinofuranosylcytosine Triphosphate; Cell Line; Cell Survival; Clone Cells; Cytarabine; Deoxyribonucleotides; Deoxyuridine; Drug Interactions; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Leukemia L1210; Mice; Uridine	1982
The potential for clinical application of in vitro assays predicting 5-FU sensitivity in man. Cancer treatment reports, 1981, Volume: 65 Suppl 3 Topics: Breast Neoplasms; Cell-Free System; Cytosol; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; In Vitro Techniques; Phosphorylation; Uridine	1981
Enhancement of the incorporation of 5-fluorodeoxyuridylate into DNA of HL-60 cells by metabolic modulations. Cancer research, 1983, Volume: 43, Issue:11 Topics: Cell Line; Deoxyuracil Nucleotides; DNA Replication; DNA, Neoplasm; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Kinetics; Leukemia, Myeloid, Acute; Methotrexate; Thymidine; Tritium	1983
Rate-limiting steps in the interactions of fluoropyrimidines and methotrexate. European journal of cancer & clinical oncology, 1984, Volume: 20, Issue:5 Topics: Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; Deoxyuridine; DNA, Neoplasm; Drug Interactions; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Methotrexate; Mice; Neoplasm Proteins; RNA, Neoplasm; Thymidine Monophosphate	1984
Synthesis and biological evaluation of neutral derivatives of 5-fluoro-2'-deoxyuridine 5'-phosphate. Journal of medicinal chemistry, 1983, Volume: 26, Issue:8 Topics: 5'-Nucleotidase; Alkaline Phosphatase; Animals; Arabinonucleotides; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Fluorouracil; Leukemia P388; Mice; Microsomes, Liver; NADP; Nucleotidases; Phosphoric Diester Hydrolases	1983
On the mechanism of cytotoxicity of fluorinated pyrimidines in four human colon adenocarcinoma xenografts maintained in immune-deprived mice. Cancer, 1980, Mar-15, Volume: 45, Issue:5 Suppl Topics: Adenocarcinoma; Animals; Cell Survival; Colonic Neoplasms; Female; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Male; Mice; Mice, Inbred CBA; Neoplasm Transplantation; Neoplasms, Experimental; Transplantation, Heterologous; Uridine	1980
Separation of several 5-fluorouracil metabolites in various melanoma cell lines. Evidence for the synthesis of 5-fluorouracil-nucleotide sugars. European journal of cancer & clinical oncology, 1984, Volume: 20, Issue:11 Topics: Animals; Aspartic Acid; Cell Line; Cells, Cultured; Chromatography; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Fluorouracil; Humans; Melanoma; Mice; Phosphonoacetic Acid; RNA, Neoplasm; Uracil Nucleotides; Uridine; Uridine Triphosphate	1984
Relationship of dUMP and free FdUMP pools to inhibition of thymidylate synthase by 5-fluorouracil. Molecular pharmacology, 1984, Volume: 25, Issue:2 Topics: Animals; Carcinoma; Cell Line; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Fluorouracil; Humans; Kinetics; Leucovorin; Methyltransferases; Sarcoma, Experimental; Thymidylate Synthase	1984
Increased levels of thymidylate synthetase in cells exposed to 5-fluorouracil. Molecular pharmacology, 1984, Volume: 25, Issue:1 Topics: Cell Line; Fluorodeoxyuridylate; Fluorouracil; Humans; Kinetics; Methyltransferases; Neoplasms; Protein Binding; Thymidylate Synthase	1984
Biochemical interactions between N-(phosphonacetyl)-L-aspartate and 5-fluorouracil. Molecular pharmacology, 1982, Volume: 21, Issue:1 Topics: Animals; Aspartic Acid; Cells, Cultured; Deoxyuracil Nucleotides; Drug Interactions; Fluorodeoxyuridylate; Fluorouracil; Kinetics; Lacticaseibacillus casei; Mice; Organophosphorus Compounds; Phosphonoacetic Acid; Sarcoma 180; Thymidylate Synthase	1982
Sequential methotrexate and 5-fluorouracil: mechanisms of synergy. Seminars in oncology, 1983, Volume: 10, Issue:2 Suppl 2 Topics: Animals; Biotransformation; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Fluorodeoxyuridylate; Fluorouracil; Folic Acid; Humans; Methotrexate; Mice; Neoplasm Transplantation; Sarcoma, Experimental; Thymidylate Synthase; Time Factors	1983
Thymidylate synthetase activity and fluorouracil sensitivity of human colonic cancer and normal mucosal tissue preparations. Cancer, 1981, Mar-15, Volume: 47, Issue:6 Topics: Adenocarcinoma; Colon; Colonic Neoplasms; Deoxyuracil Nucleotides; Dose-Response Relationship, Drug; Fluorodeoxyuridylate; Fluorouracil; Humans; Methyltransferases; Mucous Membrane; Thymidylate Synthase	1981
Increased formation of 5-fluoro-2'-deoxyuridine 5'-monophosphate from 5-fluorouracil in the presence of 2-deoxy-alpha-D-ribose 1-phosphate and 2'-deoxyuridine in Ehrlich ascites tumor cells. Nucleic acids symposium series, 1980, Issue:8 Topics: Animals; Carcinoma, Ehrlich Tumor; Deoxyuracil Nucleotides; Deoxyuridine; Fluorodeoxyuridylate; Fluorouracil; Kinetics; Mice; Pentosephosphates; Ribosemonophosphates	1980
On the rational development of a new drug: the example of the fluorinated pyrimidines. Cancer treatment reports, 1981, Volume: 65 Suppl 3 Topics: Animals; Antimetabolites, Antineoplastic; Biotransformation; Deoxyuracil Nucleotides; DNA, Neoplasm; Fluorodeoxyuridylate; Fluorouracil; Humans; RNA, Neoplasm; Thymidylate Synthase	1981
Prediction of clinical response to 5-fluorouracil-containing chemotherapy: preliminary results of in vitro assay in human breast cancer. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1980, Volume: 74 Topics: Breast Neoplasms; Cytosol; Female; Fluorodeoxyuridylate; Fluorouracil; Humans; In Vitro Techniques	1980
Biochemical determinants of responsiveness to 5-fluorouracil and its derivatives in xenografts of human colorectal adenocarcinomas in mice. Cancer research, 1981, Volume: 41, Issue:1 Topics: Adenocarcinoma; Animals; Cell Line; Colonic Neoplasms; Fluorodeoxyuridylate; Fluorouracil; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Rectal Neoplasms; Tetrahydrofolates; Thymidylate Synthase; Transplantation, Heterologous	1981
HPLC analysis of 5-FU and FdUMP in tissue and serum. Biochemical and biophysical research communications, 1995, Nov-22, Volume: 216, Issue:3 Topics: Animals; Chromatography, High Pressure Liquid; Fluorodeoxyuridylate; Fluorouracil; Hydrogen-Ion Concentration; Microchemistry; Rats	1995
Comparison of 5-fluoro-2'-deoxyuridine and 5-fluorouracil in the treatment of murine colon cancer; effects on thymidylate synthase. Advances in experimental medicine and biology, 1994, Volume: 370 Topics: Animals; Biotransformation; Cell Line; Colonic Neoplasms; Female; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Mice; Mice, Inbred BALB C; Thymidylate Synthase	1994
Cross-resistance to thymidylate synthase inhibitors in P-glycoprotein and non-P-glycoprotein cell lines. Advances in experimental medicine and biology, 1994, Volume: 370 Topics: Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Squamous Cell; Cell Cycle; Cell Line; Clone Cells; Doxorubicin; Drug Resistance, Multiple; Fluorodeoxyuridylate; Fluorouracil; Humans; Lung Neoplasms; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured	1994
Addition of leucovorin in modulation of 5-fluorouracil with methotrexate: potentiating or reversing effect? International journal of cancer, 1995, May-29, Volume: 61, Issue:5 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Cell Division; Female; Fluorodeoxyuridylate; Fluorouracil; Humans; Leucovorin; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Tumor Cells, Cultured	1995
Potentiation of the antitumor activity of 5-fluorouracil in colon carcinoma cells by the combination of interferon and deoxyribonucleosides results from complementary effects on thymidine phosphorylase. Cancer research, 1994, Mar-15, Volume: 54, Issue:6 Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Deoxyribonucleosides; Drug Synergism; Fluorodeoxyuridylate; Fluorouracil; Humans; Interferon alpha-2; Interferon-alpha; Recombinant Proteins; Stimulation, Chemical; Thymidine Phosphorylase; Thymidylate Synthase; Thymine; Tritium; Tumor Cells, Cultured	1994
Regulation of thymidylate synthase in human colon cancer cells treated with 5-fluorouracil and interferon-gamma. Advances in experimental medicine and biology, 1993, Volume: 339 Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Survival; Colonic Neoplasms; Fluorodeoxyuridylate; Fluorouracil; Humans; Interferon-gamma; Nucleic Acids; Thymidylate Synthase; Tumor Cells, Cultured	1993
Differentially potentiating effects by dipyridamole on cytotoxicity of 5-fluorouracil against three human maxillary cancer cell lines derived from a single tumor. Anti-cancer drug design, 1993, Volume: 8, Issue:4 Topics: Cell Survival; Dipyridamole; Drug Synergism; Fluorodeoxyuridylate; Fluorouracil; Humans; Maxillary Neoplasms; Tumor Cells, Cultured; Uridine Triphosphate	1993
Potentiation of 5-fluorouracil induced inhibition of thymidylate synthase in human colon tumors by leucovorin is dose dependent. Advances in experimental medicine and biology, 1993, Volume: 338 Topics: Binding Sites; Colonic Neoplasms; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Synergism; Fluorodeoxyuridylate; Fluorouracil; Humans; Kinetics; Leucovorin; Thymidylate Synthase	1993
Immunological quantitation of thymidylate synthase-FdUMP-5,10-methylenetetrahydrofolate ternary complex with the monoclonal antibody TS 106. Anti-cancer drugs, 1993, Volume: 4, Issue:4 Topics: Antibodies, Monoclonal; Blotting, Western; Colonic Neoplasms; Fluorodeoxyuridylate; Fluorouracil; Humans; Immunoblotting; Tetrahydrofolates; Thymidylate Synthase	1993
Effects of 5-fluorouracil substitution on the RNA conformation and in vitro translation of thymidylate synthase messenger RNA. The Journal of biological chemistry, 1993, Oct-05, Volume: 268, Issue:28 Topics: Blotting, Western; Catalysis; Electrophoresis, Agar Gel; Fluorodeoxyuridylate; Fluorouracil; Humans; Isoelectric Focusing; Nucleic Acid Conformation; Protein Biosynthesis; RNA, Messenger; Thymidylate Synthase	1993
Prolonged retention of high concentrations of 5-fluorouracil in human and murine tumors as compared with plasma. Cancer chemotherapy and pharmacology, 1993, Volume: 31, Issue:4 Topics: Adult; Aged; Animals; Colorectal Neoplasms; Female; Fluorodeoxyuridylate; Fluorouracil; Gas Chromatography-Mass Spectrometry; Half-Life; Humans; Injections, Intravenous; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Middle Aged; Species Specificity	1993
Suppressive effect of TNF-alpha on increased production of FdUMP by IFN-alpha. Research communications in molecular pathology and pharmacology, 1995, Volume: 89, Issue:3 Topics: Animals; Cell Line; DNA Replication; Female; Fluorodeoxyuridylate; Fluorouracil; Interferon-alpha; Mice; Mice, Inbred Strains; Thymidine Kinase; Time Factors; Tumor Necrosis Factor-alpha	1995
18F-radiopharmacokinetics of [18F]-5-fluorouracil in a mouse bearing two colon tumors with a different 5-fluorouracil sensitivity: a study for a correlation with oncological results. Nuclear medicine and biology, 1996, Volume: 23, Issue:3 Topics: Animals; Cell Line; Colonic Neoplasms; Female; Fluorine Radioisotopes; Fluorodeoxyuridylate; Fluorouracil; Isotope Labeling; Kinetics; Mice; Mice, Inbred BALB C; Thymidylate Synthase; Tissue Distribution	1996
Tumor size and origin determine the antitumor activity of cisplatin or 5-fluorouracil and its modulation by leucovorin in murine colon carcinomas. Cancer chemotherapy and pharmacology, 1996, Volume: 39, Issue:1-2 Topics: Adenocarcinoma; Animals; Antidotes; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Colonic Neoplasms; Drug Interactions; Female; Fluorodeoxyuridylate; Fluorouracil; Immunosuppressive Agents; Leucovorin; Mice; Mice, Inbred BALB C; Weight Loss	1996
Determinants of cytotoxicity with prolonged exposure to fluorouracil in human colon cancer cells. Oncology research, 1997, Volume: 9, Issue:2 Topics: Cell Division; Cell Survival; Colonic Neoplasms; Deoxyribonucleotides; Deoxyuracil Nucleotides; DNA Damage; DNA, Neoplasm; Dose-Response Relationship, Drug; Fluorodeoxyuridylate; Fluorouracil; Gene Expression Regulation, Enzymologic; Humans; Leucovorin; Thymidylate Synthase; Tumor Cells, Cultured; Uridine Triphosphate	1997
Cross-resistance to antifolates in multidrug resistant cell lines with P-glycoprotein or multidrug resistance protein expression. Biochemical pharmacology, 1997, Jun-15, Volume: 53, Issue:12 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Cell Division; Drug Resistance, Multiple; Fluorodeoxyuridylate; Fluorouracil; Folic Acid Antagonists; Gene Expression Regulation; Humans; Indoles; Isoindoles; Methotrexate; Peptide Synthases; Polymerase Chain Reaction; Quinazolines; RNA, Messenger; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured	1997
Acyclic analogues of 5-fluoro-dUMP and 5-fluoro-2'-deoxyuridine: synthesis and inhibition of thymidylate synthase and tumour cell growth. Acta biochimica Polonica, 1998, Volume: 45, Issue:1 Topics: Animals; Antineoplastic Agents; Cell Division; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Fluorodeoxyuridylate; Fluorouracil; Leukemia, Experimental; Mice; Thymidylate Synthase; Tumor Cells, Cultured	1998
Therapeutic efficacy of fluoropyrimidines depends on the duration of thymidylate synthase inhibition in the murine colon 26-B carcinoma tumor model. Clinical cancer research : an official journal of the American Association for Cancer Research, 1996, Volume: 2, Issue:8 Topics: Animals; Antimetabolites, Antineoplastic; Colonic Neoplasms; Female; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Mice; Mice, Inbred BALB C; RNA; Thymidylate Synthase; Time Factors	1996
Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil, but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines. Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:3 Topics: Antimetabolites, Antineoplastic; Binding Sites; Biological Transport; Blotting, Western; Catalysis; Cell Division; Colonic Neoplasms; Drug Screening Assays, Antitumor; Fluorodeoxyuridylate; Fluorouracil; Folic Acid Antagonists; Humans; Peptide Synthases; Pteroylpolyglutamic Acids; Thymidylate Synthase; Tritium; Tumor Cells, Cultured	1999
Increased cytotoxicity and decreased in vivo toxicity of FdUMP[10] relative to 5-FU. Nucleosides & nucleotides, 1999, Volume: 18, Issue:8 Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Biotransformation; Body Weight; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Drug Resistance, Neoplasm; Enzyme Inhibitors; Fibroblasts; Fluorodeoxyuridylate; Fluorouracil; Half-Life; Humans; Lethal Dose 50; Mice; Mice, Inbred BALB C; Neoplasm Proteins; Orotate Phosphoribosyltransferase; Prodrugs; Thymidine Kinase; Thymidylate Synthase; Tumor Cells, Cultured	1999
Mechanisms of acquired resistance to thymidylate synthase inhibitors: the role of enzyme stability. Molecular pharmacology, 1999, Volume: 56, Issue:5 Topics: Amino Acid Substitution; Antineoplastic Agents; Cell Line; Colonic Neoplasms; Drug Resistance, Neoplasm; Enzyme Inhibitors; Enzyme Stability; Fluorodeoxyuridylate; Fluorouracil; Folic Acid Antagonists; Half-Life; Humans; Peptides; RNA, Messenger; Thymidylate Synthase; Tumor Cells, Cultured	1999
Positive interaction between 5-FU and FdUMP[10] in the inhibition of human colorectal tumor cell proliferation. Antisense & nucleic acid drug development, 1999, Volume: 9, Issue:5 Topics: Antimetabolites, Antineoplastic; Cell Division; Colorectal Neoplasms; Drug Synergism; Fluorodeoxyuridylate; Fluorouracil; Humans; Prodrugs; Tumor Cells, Cultured	1999
5-ethyl-2'-deoxyuridine, a modulator of both antitumour action and pharmacokinetics of 5-fluorouracil. Journal of cancer research and clinical oncology, 1999, Volume: 125, Issue:12 Topics: Animals; Antimetabolites, Antineoplastic; Area Under Curve; Colonic Neoplasms; Deoxyuridine; Dose-Response Relationship, Drug; Drug Synergism; Fluorodeoxyuridylate; Fluorouracil; Male; Metabolic Clearance Rate; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Time Factors; Treatment Outcome; Uracil; Uridine	1999
Reduction of 5-fluorouracil (5-FU) gastrointestinal (GI) toxicity resulting from the protection of thymidylate synthase (TS) in GI tissue by repeated simultaneous administration of potassium oxonate (Oxo) in rats. Cancer chemotherapy and pharmacology, 2000, Volume: 46, Issue:1 Topics: Animals; Antimetabolites, Antineoplastic; Body Weight; Colon; Diarrhea; Digestive System; Drug Combinations; Drug Interactions; Enzyme Inhibitors; Fluorodeoxyuridylate; Fluorouracil; Ileum; Male; Oxonic Acid; Pyridines; Rats; Tegafur; Thymidylate Synthase	2000
Biochemical modulation of 5-fluorouracil with a streptococcal preparation, OK-432, against murine colon-26 carcinoma. Acta medica Okayama, 2000, Volume: 54, Issue:5 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Fluorodeoxyuridylate; Fluorouracil; Male; Mice; Picibanil; RNA; Thymidine Kinase; Thymidylate Synthase	2000
Determination of 5-fluorouracil and 5-fluoro-2'-deoxyuridine-5'-monophosphate in pancreatic cancer cell line and other biological materials using capillary electrophoresis. Journal of chromatography. A, 2001, May-04, Volume: 916, Issue:1-2 Topics: Antimetabolites, Antineoplastic; Buffers; Culture Media; Electrophoresis, Capillary; Fluorodeoxyuridylate; Fluorouracil; Humans; Pancreatic Neoplasms; Sensitivity and Specificity; Tumor Cells, Cultured	2001
Targeted drug delivery to chemoresistant cells: folic acid derivatization of FdUMP[10] enhances cytotoxicity toward 5-FU-resistant human colorectal tumor cells. The Journal of organic chemistry, 2001, Aug-24, Volume: 66, Issue:17 Topics: Antineoplastic Agents; Carrier Proteins; Colorectal Neoplasms; Drug Delivery Systems; Drug Resistance, Neoplasm; Fluorodeoxyuridylate; Fluorouracil; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Membrane Proteins; Membrane Transport Proteins; Receptors, Cell Surface; RNA, Messenger; Thymidylate Synthase; Tumor Cells, Cultured	2001
Issues of normal tissue toxicity in patient and animal studies--effect of carbogen breathing in rats after 5-fluorouracil treatment. Acta oncologica (Stockholm, Sweden), 2001, Volume: 40, Issue:5 Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Biological Availability; Bone Marrow; Carbon Dioxide; Carcinoma, Transitional Cell; Colonic Neoplasms; Colorectal Neoplasms; Combined Modality Therapy; Fatal Outcome; Female; Fluorine Radioisotopes; Fluorodeoxyuridylate; Fluorouracil; Humans; Intestine, Small; Leucovorin; Liver; Liver Neoplasms; Magnetic Resonance Imaging; Middle Aged; Neoplasms, Multiple Primary; Oxygen; Rats; Rats, Inbred WF; Sigmoid Neoplasms; Tomography, X-Ray Computed; Ultrasonography; Urinary Bladder Neoplasms	2001
Gene therapy for intraperitoneally disseminated pancreatic cancers by Escherichia coli uracil phosphoribosiltransferase (UPRT) gene mediated by restricted replication-competent adenoviral vectors. International journal of cancer, 2002, Nov-01, Volume: 102, Issue:1 Topics: Adenoviridae; Adenovirus E1B Proteins; Animals; Antimetabolites, Antineoplastic; beta-Galactosidase; Cell Division; Escherichia coli; Fluorodeoxyuridylate; Fluorouracil; Genetic Therapy; Genetic Vectors; Humans; Immunoenzyme Techniques; Injections, Intraperitoneal; Lac Operon; Male; Mice; Mice, SCID; Neoplasm Transplantation; Pancreatic Neoplasms; Pentosyltransferases; Recombination, Genetic; Transduction, Genetic; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Virus Replication	2002
Chromosomal imbalances associated with acquired resistance to fluoropyrimidines in human colorectal cancer cells. European journal of cancer (Oxford, England : 1990), 2003, Volume: 39, Issue:7 Topics: Antimetabolites, Antineoplastic; Chromosome Aberrations; Colorectal Neoplasms; DNA, Neoplasm; Drug Resistance, Neoplasm; Fluorodeoxyuridylate; Fluorouracil; Humans; Nucleic Acid Hybridization; Tumor Cells, Cultured	2003
Correlation between 5-fluorouracil metabolism and treatment response in two variants of C26 murine colon carcinoma. British journal of cancer, 2003, Aug-18, Volume: 89, Issue:4 Topics: Administration, Inhalation; Animals; Antimetabolites, Antineoplastic; Carbon Dioxide; Colonic Neoplasms; Female; Fluorodeoxyuridylate; Fluorouracil; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Oxygen; RNA, Neoplasm; Survival Rate; Thymidylate Synthase	2003
Enhanced DNA-directed effects of FdUMP[10] compared to 5FU. Nucleosides, nucleotides & nucleic acids, 2004, Volume: 23, Issue:1-2 Topics: Colonic Neoplasms; DNA; Fluorodeoxyuridylate; Fluorouracil; HT29 Cells; Humans	2004
The use of 19F spectroscopy and diffusion-weighted MRI to evaluate differences in gene-dependent enzyme prodrug therapies. Molecular therapy : the journal of the American Society of Gene Therapy, 2004, Volume: 10, Issue:5 Topics: Animals; Antineoplastic Agents; Artificial Gene Fusion; Brain; Cytosine Deaminase; Diffusion Magnetic Resonance Imaging; Flucytosine; Fluorine; Fluorodeoxyuridylate; Fluorouracil; Gene Expression; Genetic Therapy; Magnetic Resonance Spectroscopy; Neoplasms; Optic Nerve Glioma; Pentosyltransferases; Prodrugs; Rats; Transduction, Genetic	2004
A novel polypyrimidine antitumor agent FdUMP[10] induces thymineless death with topoisomerase I-DNA complexes. Cancer research, 2005, Jun-01, Volume: 65, Issue:11 Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Death; DNA Damage; DNA Topoisomerases, Type I; DNA, Neoplasm; DNA, Single-Stranded; Drug Screening Assays, Antitumor; Fluorodeoxyuridylate; Fluorouracil; Leukemia P388; Mice; Quinazolines; Thiophenes; Thymidine; Thymidylate Synthase; Topoisomerase I Inhibitors	2005
MRP8/ABCC11 directly confers resistance to 5-fluorouracil. Molecular cancer therapeutics, 2007, Volume: 6, Issue:1 Topics: Antimetabolites, Antineoplastic; Calgranulin A; Cell Death; Drug Resistance, Neoplasm; Fluorodeoxyuridylate; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Inhibitory Concentration 50; Lung Neoplasms; Multidrug Resistance-Associated Proteins; RNA, Messenger; RNA, Small Interfering	2007
Mechanisms of action of FdUMP[10]: metabolite activation and thymidylate synthase inhibition. Oncology reports, 2007, Volume: 18, Issue:1 Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Fluorodeoxyuridylate; Fluorouracil; Folic Acid Antagonists; Glutamates; Guanine; Mammary Neoplasms, Experimental; Mice; Molecular Structure; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured	2007
Synthesis of FUDP-N-acetylglucosamine and FUDP-glucose in Saccharomyces cerevisiae cells treated with 5-fluorouracil. FEMS yeast research, 2008, Volume: 8, Issue:2 Topics: Aerobiosis; Alkaline Phosphatase; Antimetabolites; Chromatography, Liquid; Culture Media; Fermentation; Fluorodeoxyuridylate; Fluorouracil; Magnetic Resonance Spectroscopy; Microbial Viability; Phosphodiesterase I; Saccharomyces cerevisiae; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrum Analysis; Uracil; Uridine Diphosphate Glucose; Uridine Diphosphate Glucose Dehydrogenase; Uridine Diphosphate N-Acetylglucosamine	2008
5-Fluorouracil and its active metabolite FdUMP cause DNA damage in human SW620 colon adenocarcinoma cell line. Journal of applied toxicology : JAT, 2009, Volume: 29, Issue:4 Topics: Antimetabolites, Antineoplastic; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Survival; Comet Assay; DNA Damage; DNA, Neoplasm; Fluorodeoxyuridylate; Fluorouracil; Histones; Humans; Micronucleus Tests; Mutagens	2009
Simultaneous quantification of 5-FU, 5-FUrd, 5-FdUrd, 5-FdUMP, dUMP and TMP in cultured cell models by LC-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2009, Oct-01, Volume: 877, Issue:27 Topics: Cell Line; Cell Line, Tumor; Chromatography, Liquid; Deoxyuracil Nucleotides; Drug Stability; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Tandem Mass Spectrometry; Thymidine Monophosphate	2009
The role of thymidine phosphorylase in the induction of early growth response protein-1 and thrombospondin-1 by 5-fluorouracil in human cancer carcinoma cells. International journal of oncology, 2010, Volume: 36, Issue:5 Topics: Antimetabolites, Antineoplastic; Carcinoma; Cell Line, Tumor; Dideoxynucleotides; Early Growth Response Protein 1; Fluorodeoxyuridylate; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Skin Neoplasms; Stomach Neoplasms; Thrombospondin 1; Thymidine Phosphorylase; Uridine Monophosphate	2010
Genome-wide mRNA and microRNA profiling of the NCI 60 cell-line screen and comparison of FdUMP[10] with fluorouracil, floxuridine, and topoisomerase 1 poisons. Molecular cancer therapeutics, 2010, Volume: 9, Issue:12 Topics: Camptothecin; Cell Line, Tumor; DNA Damage; DNA Repair; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Endocytosis; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genome, Human; Humans; Irinotecan; MicroRNAs; National Cancer Institute (U.S.); Nucleosides; RNA, Messenger; Topoisomerase I Inhibitors; Topotecan; United States	2010
Calpain regulates thymidylate synthase-5-fluoro-dUMP complex levels associated with response to 5-fluorouracil in gastric cancer cells. Cancer science, 2011, Volume: 102, Issue:8 Topics: Animals; Antimetabolites, Antineoplastic; Calpain; Cell Line, Tumor; Fluorodeoxyuridylate; Fluorouracil; Humans; Mice; NIH 3T3 Cells; Protease Inhibitors; Stomach Neoplasms; Thymidylate Synthase	2011
Development of an LC-MS/MS assay for the quantitative determination of the intracellular 5-fluorouracil nucleotides responsible for the anticancer effect of 5-fluorouracil. Journal of pharmaceutical and biomedical analysis, 2015, Jun-10, Volume: 110 Topics: Antineoplastic Agents; Biological Transport; Biotransformation; Calibration; Chromatography, Liquid; Deoxyuracil Nucleotides; Drug Monitoring; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Leukocytes, Mononuclear; Linear Models; Reference Standards; Reproducibility of Results; Tandem Mass Spectrometry; Uridine Triphosphate	2015
Two nanoformulations induce reactive oxygen species and immunogenetic cell death for synergistic chemo-immunotherapy eradicating colorectal cancer and hepatocellular carcinoma. Molecular cancer, 2021, 01-06, Volume: 20, Issue:1 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; B7-H1 Antigen; Carcinoma, Hepatocellular; Cell Line, Tumor; Colorectal Neoplasms; Disease Models, Animal; Drug Compounding; Drug Synergism; Female; Fluorodeoxyuridylate; Fluorouracil; Immunogenic Cell Death; Immunotherapy; Leucovorin; Liver Neoplasms; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Neoplasm Metastasis; Organoplatinum Compounds; Reactive Oxygen Species; Tissue Distribution	2021
The novel anti-cancer fluoropyrimidine NUC-3373 is a potent inhibitor of thymidylate synthase and an effective DNA-damaging agent. Cancer chemotherapy and pharmacology, 2023, Volume: 91, Issue:5 Topics: Antimetabolites; Colorectal Neoplasms; DNA; Enzyme Inhibitors; Fluorodeoxyuridylate; Fluorouracil; Humans; Thymidylate Synthase	2023