fluorodeoxyuridylate has been researched along with floxuridine in 49 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (48.98) | 18.7374 |
| 1990's | 15 (30.61) | 18.2507 |
| 2000's | 4 (8.16) | 29.6817 |
| 2010's | 6 (12.24) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Balzarini, J; Bentrude, WG; Béres, J; De Clercq, E; Otvös, L; Sági, G | 1 |
| Ajmera, S; Bapat, AR; Danenberg, K; Danenberg, PV | 1 |
| Balzarini, J; De Clercq, E; Hunston, RN; Jones, AS; McGuigan, C; Walker, RT | 1 |
| Danenberg, PV; Phelps, ME; Woodman, PW | 1 |
| Balińska, M; Bretner, M; Dzik, JM; Kulikowski, T; Rode, W; Shugar, D | 1 |
| Abraham, TW; Kalman, TI; McIntee, EJ; Wagner, CR | 1 |
| Bretner, M; Cieśla, J; Dzik, JM; Felczak, K; Gołos, B; Kulikowski, T; Miazga, A; Poznański, J; Rode, W; Zieliński, Z | 1 |
| Balzarini, J; Gonczy, B; Liekens, S; McGuigan, C; Murziani, P; Slusarczyk, M; Vande Voorde, J | 1 |
| Chang, J; Jiang, J; Kang, J; Li, E; Li, L; Liu, B; Peng, Y; Wang, Q; Wang, Y; Wu, J; Yang, Q; Yu, W; Zhang, J | 1 |
| Chabner, BA; Donehower, RC; Myers, CE | 1 |
| Danhauser, L; Rustum, YM; Wang, G | 1 |
| Santi, DV; Washtien, WL | 1 |
| Fujiwara, Y; Nishio, K; Ohe, Y; Ohmori, T; Saijo, N; Sugimoto, Y | 1 |
| Hoshi, A; Iigo, M; Nishikata, K | 1 |
| Harstrick, A; Rustum, YM; Zhang, ZG | 1 |
| Barberi-Heyob, M; Merlin, JL; Webér, B | 1 |
| Fujimaki, M; Kurokawa, M; Kuroki, Y; Ochiai, H; Okamoto, M; Tazawa, K; Yamashita, I | 1 |
| Fujita, H; Hori, T; Mikami, H; Miyata, S; Tai, M | 1 |
| Keyomarsi, K; Moran, RG | 1 |
| Morgan, RG | 1 |
| Brown, CS; Heath, TD | 1 |
| Fukushima, S; Hayashi, Y; Kaneko, M; Kawaguchi, T; Nakano, M | 1 |
| Fischer, PH; Grem, JL | 1 |
| Hoshi, A; Ishihara, J; Kanzawa, F; Matsushima, Y; Ohba, T; Watanabe, K | 1 |
| Benatti, U; De Flora, A; Guida, L; Polvani, C; Zocchi, E | 1 |
| Almersjö, O; Berne, M; Gustavsson, B; Spears, P; Sundström, E | 1 |
| Keyomarsi, K; Moran, RG; Patel, R | 1 |
| Au, JL; Luccioni, CM; Rustum, YM; Wientjes, MG | 1 |
| Cadman, E; Grant, S | 1 |
| Ardalan, B; Cooney, D; Lippman, M; Macdonald, J; Schein, P | 1 |
| Kimura, K; Tanaka, M; Yoshida, S | 1 |
| Bailey, BD; Bowen, D; Guernsey, LA | 1 |
| Cranford, SK; Fernandes, DJ | 1 |
| Houghton, JA; Houghton, PJ | 1 |
| Baugh, CM; Gaumont, Y; Kisliuk, RL; Lafer, E; Montgomery, JA | 1 |
| Danenberg, PV; Lockshin, A | 1 |
| Peters, GJ; Rustum, YM; Smid, K; van der Wilt, CL; van Laar, JA | 1 |
| Balbi, A; Benatti, U; Damonte, G; De Flora, A; Gasparini, A; Giovine, M; Grandi, T; Mazzei, M; Silvestro, L; Tonetti, M | 1 |
| Bretner, M; Dzik, JM; Gołos, B; Jarmuła, A; Kulikowski, T; Poznański, J; Rode, W; Shugar, D | 1 |
| Fujimaki, M; Katuyama, S; Kuroki, Y; Okamoto, M; Sakamoto, T; Tazawa, K; Yamashita, I | 1 |
| Noordhuis, P; Peters, GJ; Pinedo, HM; Rustum, YM; Smid, K; van der Wilt, CL; van Laar, JA | 1 |
| Berger, SH; Steadman, DJ; Zapf, JW; Zhao, PS | 1 |
| Cattaneo-Pangrazzi, RM; Schott, H; Schwendener, RA | 1 |
| Borch, RF; Tobias, SC | 1 |
| Carli, D; Cohen, S; Dumontet, C; Guitton, J; Honorat, M; Megherbi, M; Payen, L; Vignal, B | 1 |
| Bijnsdorp, IV; Fichtner, I; Honeywell, RJ; Laan, AC; Losekoot, N; Peters, GJ; Schott, H; Schott, S; Schwendener, RA; Smid, K | 1 |
| Gmeiner, WH; Pommier, Y; Reinhold, WC | 1 |
| Berger, A; Busch, C; Garbe, C; Ikenberg, K; Meier, F; Niessner, H; Schott, S; Sinnberg, T; Venturelli, S; Villanueva, J | 1 |
| Beijnen, JH; Derissen, EJ; Hillebrand, MJ; Rosing, H; Schellens, JH | 1 |
2 review(s) available for fluorodeoxyuridylate and floxuridine
| Article | Year |
|---|---|
Leucovorin enhancement of the effects of the fluoropyrimidines on thymidylate synthase.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Synergism; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Leucovorin; Neoplasms; Thymidylate Synthase | 1989 |
Fluorinated pyrimidines as tight-binding inhibitors of thymidylate synthetase.
Topics: Amino Acid Sequence; Amino Acids; Animals; Chemical Phenomena; Chemistry; Deoxyuracil Nucleotides; Floxuridine; Fluorodeoxyuridylate; Kinetics; Methyltransferases; Thymidylate Synthase; Thymine Nucleotides; Trifluridine | 1981 |
47 other study(ies) available for fluorodeoxyuridylate and floxuridine
| Article | Year |
|---|---|
Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cell Line; Deoxyuracil Nucleotides; Drug Evaluation, Preclinical; Humans; Hydrocarbons, Halogenated; Indicators and Reagents; Leukemia L1210; Magnetic Resonance Spectroscopy; Mice; Simplexvirus; Structure-Activity Relationship; Vaccinia virus; Vesicular stomatitis Indiana virus | 1986 |
Synthesis and biological activity of 5-fluoro-2',3'-dideoxy-3'-fluorouridine and its 5'-phosphate.
Topics: Animals; Cell Division; Deoxyuracil Nucleotides; Dideoxynucleosides; Dideoxynucleotides; Floxuridine; Indicators and Reagents; Kinetics; Leukemia L1210; Lung Neoplasms; Methyltransferases; Mice; Pentosyltransferases; Thymidine Phosphorylase; Thymidylate Synthase | 1984 |
Synthesis and biological properties of some cyclic phosphotriesters derived from 2'-deoxy-5-fluorouridine.
Topics: Animals; Antimetabolites, Antineoplastic; Bromodeoxyuridine; Deoxycytidine; Deoxyuridine; Drug Resistance; Indicators and Reagents; Leukemia L1210; Mice; Organophosphorus Compounds; Structure-Activity Relationship; Thymidine; Thymidine Monophosphate | 1984 |
Synthesis and biological activity of 5-fluoro-2'-deoxyuridine 5'-phosphorodiamidates.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chemical Phenomena; Chemistry; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Lacticaseibacillus casei; Leukemia, Experimental; Mice; Thymidylate Synthase | 1980 |
2-Thio derivatives of dUrd and 5-fluoro-dUrd and their 5'-monophosphates: synthesis, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
Topics: 3T3 Cells; Animals; Antineoplastic Agents; Binding, Competitive; Carcinoma, Ehrlich Tumor; Cell Division; Deoxyuracil Nucleotides; Drug Screening Assays, Antitumor; Floxuridine; Kinetics; Leukemia L1210; Mice; Spectrophotometry; Stereoisomerism; Structure-Activity Relationship; Thiouridine; Thymidylate Synthase; Tumor Cells, Cultured | 1993 |
Synthesis and biological activity of aromatic amino acid phosphoramidates of 5-fluoro-2'-deoxyuridine and 1-beta-arabinofuranosylcytosine: evidence of phosphoramidase activity.
Topics: Animals; Cell Division; Cell Line; Cytarabine; Floxuridine; Humans; Magnetic Resonance Spectroscopy; Mice; Organophosphorus Compounds; Phosphoric Monoester Hydrolases; Thymidylate Synthase; Tumor Cells, Cultured | 1996 |
5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
Topics: Animals; Antineoplastic Agents; Bromodeoxyuridine; Catalysis; Cell Division; Deoxycytidine; Deoxycytidine Monophosphate; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Idoxuridine; Kinetics; Mice; Molecular Conformation; Stereoisomerism; Structure-Activity Relationship; Thymidylate Synthase; Tumor Cells, Cultured | 2000 |
Phosphoramidate ProTides of the anticancer agent FUDR successfully deliver the preformed bioactive monophosphate in cells and confer advantage over the parent nucleoside.
Topics: Antineoplastic Agents; Cell Culture Techniques; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Equilibrative Nucleoside Transporter 1; Floxuridine; Humans; Mycoplasma hyorhinis; Organophosphorus Compounds; Prodrugs; Pyrimidine Phosphorylases; Structure-Activity Relationship | 2011 |
Discovery of an Orally Active and Liver-Targeted Prodrug of 5-Fluoro-2'-Deoxyuridine for the Treatment of Hepatocellular Carcinoma.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Area Under Curve; Carcinoma, Hepatocellular; Deoxyuridine; Drug Discovery; Liver; Liver Neoplasms, Experimental; Mice; Prodrugs; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2016 |
New developments on the mechanisms of action of antineoplastic drugs.
Topics: Antineoplastic Agents; Bleomycin; Doxorubicin; Drug Interactions; Drug Synergism; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Methotrexate | 1979 |
Selectivity of action of 5-FU: biochemical basis.
Topics: Animals; Colonic Neoplasms; Drug Resistance; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Leukemia L1210; Mice; Mice, Inbred Strains; Rats; RNA, Neoplasm; Thymidine; Uridine | 1979 |
Assay of intracellular free and macromolecular-bound metabolites of 5-fluorodeoxyuridine and 5-fluorouracil.
Topics: Animals; Chromatography, Gel; Culture Techniques; Cytosol; Deoxyuracil Nucleotides; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Kinetics; Leukemia L1210; Rats; RNA; Thymidine Kinase | 1979 |
In vitro enhancement of fluoropyrimidine-induced cytotoxicity by leucovorin in colorectal and gastric carcinoma cell lines but not in non-small-cell lung carcinoma cell lines.
Topics: Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Cell Survival; Colony-Forming Units Assay; Colorectal Neoplasms; Drug Synergism; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Leucovorin; Lung Neoplasms; Stomach Neoplasms; Tetrahydrofolates; Thymidylate Synthase; Tumor Cells, Cultured | 1992 |
In vivo antitumor effects of fluoropyrimidines on colon adenocarcinoma 38 and enhancement by leucovorin.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Cell Division; Colonic Neoplasms; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Leucovorin; Male; Mice; Mice, Inbred Strains; Thymidylate Synthase; Uridine | 1992 |
Mechanisms of resistance to fluoropyrimidines.
Topics: Cecal Neoplasms; Deoxyuracil Nucleotides; Drug Resistance; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Ileal Neoplasms; Leucovorin; Tetrahydrofolates; Thymidylate Synthase; Tumor Cells, Cultured | 1992 |
Determination of 5-fluorouracil and its main metabolites in plasma by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Hydrogen-Ion Concentration; Phosphates; Potassium; Potassium Compounds; Spectrophotometry, Ultraviolet; Uridine | 1992 |
[Antitumor activity of T-506, a novel synthetic FUDR derivative, on murine colon cancer and its hepatic metastasis].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Floxuridine; Fluorodeoxyuridylate; Liver Neoplasms; Mice; Mice, Inbred BALB C; Tegafur; Uracil | 1991 |
Competitive binding radioassay for the determination of 5-fluorodeoxyuridine and 5-fluorodeoxyuridine-5'-monophosphate levels in plasma and tumor tissue.
Topics: Animals; Carcinoma, Ehrlich Tumor; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Kinetics; Lacticaseibacillus casei; Mice; Mice, Inbred Strains; Radioligand Assay; Thymidine Kinase; Thymidylate Synthase; Tritium | 1991 |
Quinazoline folate analogs inhibit the catalytic activity of thymidylate synthase but allow binding of 5-fluorodeoxyuridylate.
Topics: Animals; Binding Sites; Cytidine Monophosphate; Floxuridine; Fluorodeoxyuridylate; Folic Acid; Folic Acid Antagonists; Kinetics; Leukemia L1210; Mice; Models, Structural; Protein Binding; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase | 1990 |
Targeted drug delivery: a two-compartment growth inhibition assay demonstrates that fluorodeoxyuridine and fluorodeoxyuridine monophosphate are liposome-independent drugs.
Topics: Biopharmaceutics; Deoxyuracil Nucleotides; Drug Carriers; Floxuridine; Fluorodeoxyuridylate; Liposomes | 1989 |
Selective accumulation of 3',5'-dioctanoyl-5-fluoro-2'-deoxyuridine (FdUrd-C8) and sustained release of its active metabolites in VX-2 rabbit hepatoma following intraarterial administration of FdUrd-C8 solution in Lipiodol.
Topics: Animals; Esterases; Floxuridine; Fluorodeoxyuridylate; Hepatic Artery; Infusions, Intra-Arterial; Iodized Oil; Liver; Liver Neoplasms, Experimental; Male; Pentosyltransferases; Pyrimidine Phosphorylases; Rabbits; Tissue Distribution | 1988 |
Alteration of fluorouracil metabolism in human colon cancer cells by dipyridamole with a selective increase in fluorodeoxyuridine monophosphate levels.
Topics: Cells, Cultured; Colonic Neoplasms; Deoxyuracil Nucleotides; Deoxyuridine; Dipyridamole; DNA; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Ribonucleotides; Time Factors; Uridine Triphosphate | 1986 |
Antitumor activity of alkylesters of 5-fluoro-2'-deoxyuridine 5'-monophosphate (FdUMP) against murine lymphoma L5178Y resistant to 5-fluoro-2'-deoxyuridine.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Deoxyuracil Nucleotides; Drug Resistance; Floxuridine; Fluorodeoxyuridylate; Lymphoma; Mice; Structure-Activity Relationship | 1986 |
Conversion of encapsulated 5-fluoro-2'-deoxyuridine 5'-monophosphate to the antineoplastic drug 5-fluoro-2'-deoxyuridine in human erythrocytes.
Topics: Antineoplastic Agents; Biotransformation; Deoxyuracil Nucleotides; Drug Compounding; Erythrocytes; Floxuridine; Fluorodeoxyuridylate; Hemolysis; Humans; In Vitro Techniques; Microscopy, Electron, Scanning | 1988 |
Inhibition of thymidylate synthase after administration of doxifluridine in a transplantable colon carcinoma in the rat.
Topics: Animals; Carcinoma; Colonic Neoplasms; Female; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Male; Neoplasm Transplantation; Rats; Rats, Inbred Strains; Thymidylate Synthase | 1988 |
Tumor cell responses to inhibition of thymidylate synthase.
Topics: Animals; Cell Line; Cell Survival; Drug Screening Assays, Antitumor; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Kinetics; Leucovorin; Protein Binding; Thymidylate Synthase; Tumor Cells, Cultured | 1988 |
Reversed-phase ion-pair high-performance liquid chromatographic assay of 5-fluorouracil, 5'-deoxy-5-fluorouridine, their nucleosides, mono-, di-, and triphosphate nucleotides with a mixture of quaternary ammonium ions.
Topics: Chromatography, High Pressure Liquid; Deoxyuracil Nucleotides; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Isomerism; Structure-Activity Relationship; Uracil Nucleotides; Uridine | 1982 |
Modulation of 1-beta-D-arabinofuranosylcytosine metabolism and cytotoxicity in L1210 cells by fluoropyrimidine pretreatment.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Cell Line; Cell Survival; Clone Cells; Cytarabine; Deoxyribonucleotides; Deoxyuridine; Drug Interactions; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Leukemia L1210; Mice; Uridine | 1982 |
The potential for clinical application of in vitro assays predicting 5-FU sensitivity in man.
Topics: Breast Neoplasms; Cell-Free System; Cytosol; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; In Vitro Techniques; Phosphorylation; Uridine | 1981 |
Enhancement of the incorporation of 5-fluorodeoxyuridylate into DNA of HL-60 cells by metabolic modulations.
Topics: Cell Line; Deoxyuracil Nucleotides; DNA Replication; DNA, Neoplasm; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Kinetics; Leukemia, Myeloid, Acute; Methotrexate; Thymidine; Tritium | 1983 |
Rate-limiting steps in the interactions of fluoropyrimidines and methotrexate.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; Deoxyuridine; DNA, Neoplasm; Drug Interactions; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Methotrexate; Mice; Neoplasm Proteins; RNA, Neoplasm; Thymidine Monophosphate | 1984 |
A method for the determination of total, free, and 5-fluorodeoxyuridylate-bound thymidylate synthase in cell extracts.
Topics: Binding Sites; Cell Line; Floxuridine; Fluorodeoxyuridylate; Humans; Leukemia; Methyltransferases; Protein Binding; Substrate Specificity; Thymidylate Synthase | 1984 |
On the mechanism of cytotoxicity of fluorinated pyrimidines in four human colon adenocarcinoma xenografts maintained in immune-deprived mice.
Topics: Adenocarcinoma; Animals; Cell Survival; Colonic Neoplasms; Female; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Male; Mice; Mice, Inbred CBA; Neoplasm Transplantation; Neoplasms, Experimental; Transplantation, Heterologous; Uridine | 1980 |
Polyglutamyl derivatives of tetrahydrofolate as substrates for Lactobacillus casei thymidylate synthase.
Topics: Deoxyuridine; Floxuridine; Fluorodeoxyuridylate; Iodoacetamide; Kinetics; Lacticaseibacillus casei; Methyltransferases; Sodium Chloride; Substrate Specificity; Tetrahydrofolates; Thymidylate Synthase | 1981 |
Comparison of 5-fluoro-2'-deoxyuridine and 5-fluorouracil in the treatment of murine colon cancer; effects on thymidylate synthase.
Topics: Animals; Biotransformation; Cell Line; Colonic Neoplasms; Female; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Mice; Mice, Inbred BALB C; Thymidylate Synthase | 1994 |
A novel dimeric fluoropyrimidine molecule behaves as a remote precursor of 5-fluoro-2'-deoxyuridine in human erythrocytes.
Topics: Erythrocytes; Floxuridine; Fluorodeoxyuridylate; Humans; Mass Spectrometry; Prodrugs; Pyrimidines | 1994 |
Synthesis and interactions with thymidylate synthase of 2,4-dithio analogues of dUMP and 5-fluoro-dUMP.
Topics: Animals; Binding Sites; Cell Division; Deoxyuracil Nucleotides; Drug Resistance, Neoplasm; Enzyme Inhibitors; Floxuridine; Fluorodeoxyuridylate; Kinetics; Leukemia L1210; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Structure; Phosphorylation; Phosphotransferases; Protein Binding; Thionucleotides; Thymidylate Synthase; Tumor Cells, Cultured | 1996 |
Inhibitory effects of fluorinated pyrimidines, 5'-DFUR, UFT and T-506, in a model of hepatic metastasis of mouse colon 26 adenocarcinoma-assessment of inhibitory activity and adverse reactions at the maximum tolerated dose.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Body Weight; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Combinations; Female; Floxuridine; Fluorodeoxyuridylate; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Tegafur; Uracil | 1997 |
Therapeutic efficacy of fluoropyrimidines depends on the duration of thymidylate synthase inhibition in the murine colon 26-B carcinoma tumor model.
Topics: Animals; Antimetabolites, Antineoplastic; Colonic Neoplasms; Female; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Mice; Mice, Inbred BALB C; RNA; Thymidylate Synthase; Time Factors | 1996 |
Genetic complementation and resistance to 5-fluoro-2'-deoxyuridine in thymidine auxotrophs expressing a highly defective mutant of human thymidylate synthase.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Cell Line; Cricetinae; Cricetulus; Drug Resistance; Floxuridine; Fluorodeoxyuridylate; Genetic Complementation Test; Humans; Point Mutation; Thymidine; Thymidylate Synthase; Transfection | 1999 |
The novel heterodinucleoside dimer 5-FdU-NOAC is a potent cytotoxic drug and a p53-independent inducer of apoptosis in the androgen-independent human prostate cancer cell lines PC-3 and DU-145.
Topics: Androgens; Antimetabolites, Antineoplastic; Apoptosis; Biotransformation; Cell Cycle; Cell Division; Cytarabine; Dimerization; Dose-Response Relationship, Drug; Enzyme Inhibitors; Floxuridine; Fluorodeoxyuridylate; Humans; Hydrolysis; Male; Neoplasms, Hormone-Dependent; Phosphodiesterase I; Phosphoric Diester Hydrolases; Prodrugs; Prostatic Neoplasms; Thymidylate Synthase; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2000 |
Synthesis and biological studies of novel nucleoside phosphoramidate prodrugs.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Floxuridine; Fluorodeoxyuridylate; Magnetic Resonance Spectroscopy; Mice; Prodrugs; Thymidine Kinase; Thymidylate Synthase; Tumor Cells, Cultured; Uridine Monophosphate | 2001 |
Simultaneous quantification of 5-FU, 5-FUrd, 5-FdUrd, 5-FdUMP, dUMP and TMP in cultured cell models by LC-MS/MS.
Topics: Cell Line; Cell Line, Tumor; Chromatography, Liquid; Deoxyuracil Nucleotides; Drug Stability; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Tandem Mass Spectrometry; Thymidine Monophosphate | 2009 |
Cellular pharmacology of multi- and duplex drugs consisting of ethynylcytidine and 5-fluoro-2'-deoxyuridine.
Topics: Animals; Cell Line, Tumor; Cytidine; Drug Resistance, Neoplasm; Extracellular Space; Floxuridine; Fluorodeoxyuridylate; Humans; Inhibitory Concentration 50; Liposomes; Mice; Nucleoside Transport Proteins; Nucleosides; Thymidylate Synthase; Xenograft Model Antitumor Assays | 2011 |
Genome-wide mRNA and microRNA profiling of the NCI 60 cell-line screen and comparison of FdUMP[10] with fluorouracil, floxuridine, and topoisomerase 1 poisons.
Topics: Camptothecin; Cell Line, Tumor; DNA Damage; DNA Repair; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Endocytosis; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genome, Human; Humans; Irinotecan; MicroRNAs; National Cancer Institute (U.S.); Nucleosides; RNA, Messenger; Topoisomerase I Inhibitors; Topotecan; United States | 2010 |
Cytotoxicity of new duplex drugs linking 3'-C-ethynylcytidine and 5-fluor-2'-deoxyuridine against human melanoma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Chick Embryo; Cytidine; Cytidine Monophosphate; Drug Discovery; Drug Screening Assays, Antitumor; Floxuridine; Fluorodeoxyuridylate; Humans; Indoles; Melanoma; Mice; Mice, Nude; Oligonucleotides; Random Allocation; Sulfonamides; Vemurafenib; Xenograft Model Antitumor Assays | 2012 |
Development of an LC-MS/MS assay for the quantitative determination of the intracellular 5-fluorouracil nucleotides responsible for the anticancer effect of 5-fluorouracil.
Topics: Antineoplastic Agents; Biological Transport; Biotransformation; Calibration; Chromatography, Liquid; Deoxyuracil Nucleotides; Drug Monitoring; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Leukocytes, Mononuclear; Linear Models; Reference Standards; Reproducibility of Results; Tandem Mass Spectrometry; Uridine Triphosphate | 2015 |