fluorodeoxyuridylate has been researched along with 5,10-methylenetetrahydrofolic acid in 33 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (48.48) | 18.7374 |
| 1990's | 15 (45.45) | 18.2507 |
| 2000's | 2 (6.06) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ivanetich, KM; James, TL; Lam, SS; Pogolotti, AL; Santi, DV; Wataya, Y | 1 |
| Fujiwara, Y; Nishio, K; Ohe, Y; Ohmori, T; Saijo, N; Sugimoto, Y | 1 |
| Harstrick, A; Rustum, YM; Zhang, ZG | 1 |
| Cisneros, RJ; Dunlap, RB | 2 |
| Freer, S; Janson, CA; Matthews, DA; Smith, WW; Villafranca, JE; Welsh, K | 1 |
| Dreyfuss, A; el-Magharbel, I; Frei, E; Holden, SA; Jones, SM; Rosowsky, A; Trites, D; Wright, JE | 1 |
| Houghton, JA; Houghton, PJ; Radparvar, S | 1 |
| Gustavsson, BG; Spears, CP | 1 |
| Maley, F; Maley, GF | 1 |
| Lu, Y; Newman, EM; Priest, DG; Scanlon, KJ | 1 |
| Ahmed, F; Dunlap, RB; Moore, MA | 1 |
| Danenberg, PV; Pellino, AM | 1 |
| Doig, MT; Priest, DG | 1 |
| Dunlap, RB; Ellis, PD; Lewis, CA | 1 |
| Houghton, JA; Houghton, PJ; Schmidt, C | 1 |
| Danenberg, PV; Lockshin, A | 1 |
| Bruice, TW; Santi, DV | 1 |
| Cadman, E; Heimer, R | 1 |
| Beckage, MJ; Blumenstein, M; Kisliuk, RL | 1 |
| Bretner, M; Cieśla, J; Dzik, JM; Gołos, B; Kempny, M; Kulikowski, T; Machnicka, B; Makowski, M; Pawełczak, K; Rzeszotarska, B | 1 |
| Connick, TJ; Dunlap, RB; Ellis, PD; Reilly, RT | 1 |
| Allegra, CJ; Drake, JC; Johnston, PG | 1 |
| Cisneros, RJ; Dunlap, RB; Zapf, JW | 1 |
| Allegra, CJ; Chu, E | 1 |
| Hyatt, DC; Maley, F; Montfort, WR | 1 |
| Berger, FG; Forsthoefel, AM; Reilly, RT | 1 |
| Adamowicz, L; Leś, A; Rode, W | 1 |
| Chiericatti, G; Santi, DV | 1 |
| Biermann, D; Finer-Moore, J; Michelitsch, MD; Nissen, R; Sage, CR; Stout, TJ; Stroud, RM | 1 |
| Berger, FG; Fantz, C; Forsthoefel, A; Jennings, W; Kitchens, M; Lebioda, L; Minor, W; Phan, J; Shaw, D; Spencer, HT | 1 |
| Anderson, KS; Dasgupta, T | 1 |
| Bertino, JR; Dolnick, BJ; Rode, W | 1 |
33 other study(ies) available for fluorodeoxyuridylate and 5,10-methylenetetrahydrofolic acid
| Article | Year |
|---|---|
Thymidylate synthetase: fluorine-19 nmr characterization of the active site peptide covalently bound to 5-fluoro-2'-deoxyuridylate and 5,10-methylenetetrahydrofolate.
Topics: Binding Sites; Fluorine; Fluorodeoxyuridylate; Fourier Analysis; Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; Methyltransferases; Protein Binding; Protein Conformation; Tetrahydrofolates; Thymidylate Synthase; Uracil Nucleotides | 1976 |
In vitro enhancement of fluoropyrimidine-induced cytotoxicity by leucovorin in colorectal and gastric carcinoma cell lines but not in non-small-cell lung carcinoma cell lines.
Topics: Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Cell Survival; Colony-Forming Units Assay; Colorectal Neoplasms; Drug Synergism; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Leucovorin; Lung Neoplasms; Stomach Neoplasms; Tetrahydrofolates; Thymidylate Synthase; Tumor Cells, Cultured | 1992 |
Mechanisms of resistance to fluoropyrimidines.
Topics: Cecal Neoplasms; Deoxyuracil Nucleotides; Drug Resistance; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Ileal Neoplasms; Leucovorin; Tetrahydrofolates; Thymidylate Synthase; Tumor Cells, Cultured | 1992 |
Characterization of the parameters affecting covalent binding stoichiometry in binary and ternary complexes of thymidylate synthase.
Topics: Buffers; Fluorodeoxyuridylate; Hydrogen-Ion Concentration; Kinetics; Lacticaseibacillus casei; Protein Binding; Tetrahydrofolates; Thermodynamics; Thymidylate Synthase | 1990 |
Stereochemical mechanism of action for thymidylate synthase based on the X-ray structure of the covalent inhibitory ternary complex with 5-fluoro-2'-deoxyuridylate and 5,10-methylenetetrahydrofolate.
Topics: Binding Sites; Deoxyuracil Nucleotides; Escherichia coli; Fluorodeoxyuridylate; Folic Acid Antagonists; Hydrogen Bonding; Ligands; Models, Molecular; Protein Conformation; Tetrahydrofolates; Thymidylate Synthase; X-Ray Diffraction | 1990 |
Development of a trichloroacetic acid precipitation assay for covalent adducts of thymidylate synthase.
Topics: Bacterial Proteins; Chemical Precipitation; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thymidylate Synthase; Trichloroacetic Acid | 1990 |
Selective expansion of 5,10-methylenetetrahydrofolate pools and modulation of 5-fluorouracil antitumor activity by leucovorin in vivo.
Topics: Animals; Female; Fluorodeoxyuridylate; Fluorouracil; Leucovorin; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Tetrahydrofolates | 1989 |
Effect of polyglutamylation of 5,10-methylenetetrahydrofolate on the binding of 5-fluoro-2'-deoxyuridylate to thymidylate synthase purified from a human colon adenocarcinoma xenograft.
Topics: Adenocarcinoma; Colonic Neoplasms; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Folic Acid; Humans; In Vitro Techniques; Kinetics; Pteroylpolyglutamic Acids; Structure-Activity Relationship; Tetrahydrofolates; Thymidylate Synthase | 1989 |
Methods for thymidylate synthase pharmacodynamics: serial biopsy, free and total TS, FdUMP and dUMP, and H4PteGlu and CH2-H4PteGlu assays.
Topics: Biopsy, Needle; Cytosol; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Humans; Lacticaseibacillus casei; Neoplasms; Radioisotope Dilution Technique; Tetrahydrofolates; Thymidylate Synthase; Tritium | 1988 |
Properties of a defined mutant of Escherichia coli thymidylate synthase.
Topics: Amino Acids; Cysteine; Escherichia coli; Fluorodeoxyuridylate; Folic Acid; Mutation; Peptide Mapping; Quinazolines; Structure-Activity Relationship; Tetrahydrofolates; Thymidylate Synthase; Tyrosine | 1988 |
Biochemical basis for cisplatin and 5-fluorouracil synergism in human ovarian carcinoma cells.
Topics: Carcinoma; Cell Line; Cisplatin; Drug Synergism; Female; Fluorodeoxyuridylate; Fluorouracil; Folic Acid; Humans; Ovarian Neoplasms; Tetrahydrofolates; Thymidine Monophosphate; Thymidylate Synthase | 1986 |
A nitrocellulose-filter assay for the binary complex of 5-fluorodeoxyuridylate and Lactobacillus casei thymidylate synthetase.
Topics: Chemical Phenomena; Chemistry; Collodion; Deoxyuracil Nucleotides; Filtration; Fluorodeoxyuridylate; Lacticaseibacillus casei; Methyltransferases; Protein Binding; Protein Denaturation; Tetrahydrofolates; Thymidylate Synthase | 1985 |
Evidence from chemical degradation studies for a covalent bond from 5-fluoro-2'-deoxyuridylate to N-5 of tetrahydrofolate in the ternary complex of thymidylate synthetase-5-fluoro-2'-deoxyuridylate-5,10-methylenetetrahydrofolate.
Topics: Carbon Radioisotopes; Colorimetry; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Folic Acid; Lacticaseibacillus casei; Methyltransferases; Protein Binding; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thymidylate Synthase; Tritium | 1985 |
Evaluation of folylpolyglutamates by electrophoretic separation of fluorodeoxyuridylate-thymidylate synthase-methylenetetrahydrofolate complexes.
Topics: Animals; Deoxyuracil Nucleotides; Electrophoresis, Polyacrylamide Gel; Fluorodeoxyuridylate; Folic Acid; Kinetics; Lacticaseibacillus casei; Liver; Methyltransferases; Mice; Protein Binding; Pteroylpolyglutamic Acids; Saccharomyces cerevisiae; Species Specificity; Tetrahydrofolates; Thymidylate Synthase | 1983 |
Fluorine-19 nuclear magnetic resonance characterization of ternary complexes of folate derivatives, 5-fluorodeoxyuridylate and Lactobacillus.
Topics: Aminopterin; Binding Sites; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Folic Acid; Folic Acid Antagonists; Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; Methotrexate; Methyltransferases; Protein Binding; Structure-Activity Relationship; Tetrahydrofolates; Thymidylate Synthase | 1981 |
The effect of derivatives of folic acid on the fluorodeoxyuridylate-thymidylate synthetase covalent complex in human colon xenografts.
Topics: Adenocarcinoma; Animals; Cell Line; Colonic Neoplasms; Deoxyuracil Nucleotides; Female; Fluorodeoxyuridylate; Folic Acid; Homocysteine; Humans; Methyltransferases; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Rectal Neoplasms; Tetrahydrofolates; Thymidylate Synthase; Transplantation, Heterologous; Vitamin B 12 | 1982 |
Hydrodynamic behavior of human and bacterial thymidylate synthetases and thymidylate synthetase--5-fluoro-2'-deoxyuridylate--5,10-methylenetetrahydrofolate complexes. Evidence for large conformational changes during catalysis.
Topics: Binding Sites; Cell Line; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Humans; Kinetics; Lactobacillus; Leukemia, Lymphoid; Methyltransferases; Protein Binding; Protein Conformation; Species Specificity; Tetrahydrofolates; Thymidylate Synthase | 1980 |
Secondary alpha-hydrogen isotope effects on the interaction of 5-fluoro-2'-deoxyuridylate and 5,10-methylenetetrahydrofolate with thymidylate synthetase.
Topics: Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Hydrogen; Kinetics; Methyltransferases; Tetrahydrofolates; Thymidylate Synthase | 1982 |
Analysis of the thymidylate synthetase ternary complex by high-performance liquid steric exclusion chromatography.
Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Fluorodeoxyuridylate; Leukemia L1210; Methyltransferases; Mice; Protein Conformation; Tetrahydrofolates; Thymidylate Synthase | 1981 |
19F NMR studies of the binding of 5-fluoro-2'-deoxyuridylate to thymidylate synthase.
Topics: Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Methyltransferases; Molecular Conformation; Spectrum Analysis; Tetrahydrofolates; Thymidylate Synthase | 1980 |
Thymidylate synthases from Hymenolepis diminuta and regenerating rat liver: purification, properties, and inhibition by substrate and cofactor analogues.
Topics: Animals; Fluorodeoxyuridylate; Hymenolepis; Kinetics; Liver; Liver Regeneration; Male; Molecular Weight; Rats; Rats, Wistar; Temperature; Tetrahydrofolates; Thymidylate Synthase | 1995 |
Phosphorus-31 nuclear magnetic resonance studies of complexes of thymidylate synthase.
Topics: Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Folic Acid; Magnetic Resonance Spectroscopy; Phosphorus Isotopes; Quinazolines; Tetrahydrofolates; Thymidine Monophosphate; Thymidylate Synthase | 1994 |
Immunological quantitation of thymidylate synthase-FdUMP-5,10-methylenetetrahydrofolate ternary complex with the monoclonal antibody TS 106.
Topics: Antibodies, Monoclonal; Blotting, Western; Colonic Neoplasms; Fluorodeoxyuridylate; Fluorouracil; Humans; Immunoblotting; Tetrahydrofolates; Thymidylate Synthase | 1993 |
Studies of 5-fluorodeoxyuridine 5'-monophosphate binding to carboxypeptidase A-inactivated thymidylate synthase from Lactobacillus casei.
Topics: Binding Sites; Carboxypeptidases; Carboxypeptidases A; Enzymes, Immobilized; Fluorodeoxyuridylate; Folic Acid; Kinetics; Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; Protein Binding; Tetrahydrofolates; Thymidylate Synthase | 1993 |
The role of thymidylate synthase in cellular regulation.
Topics: Antineoplastic Agents; Blotting, Southern; Colonic Neoplasms; Electrophoresis, Polyacrylamide Gel; Fluorodeoxyuridylate; Gene Expression Regulation, Neoplastic; Humans; Polymerase Chain Reaction; Precipitin Tests; Protein Biosynthesis; RNA-Binding Proteins; RNA, Messenger; Tetrahydrofolates; Thymidylate Synthase; Tumor Cells, Cultured; Uridine; Uridine Monophosphate | 1996 |
Use of strain in a stereospecific catalytic mechanism: crystal structures of Escherichia coli thymidylate synthase bound to FdUMP and methylenetetrahydrofolate.
Topics: Catalysis; Crystallography, X-Ray; Enzyme Activation; Escherichia coli; Fluorodeoxyuridylate; Ligands; Models, Molecular; Molecular Sequence Data; Protein Conformation; Protons; Species Specificity; Stereoisomerism; Tetrahydrofolates; Thymidylate Synthase; Tyrosine | 1997 |
Functional effects of amino acid substitutions at residue 33 of human thymidylate synthase.
Topics: Blotting, Western; Enzyme Inhibitors; Escherichia coli; Fluorodeoxyuridylate; Genetic Complementation Test; Histidine; Humans; Kinetics; Mutagenesis, Site-Directed; Protein Binding; Recombinant Proteins; Tetrahydrofolates; Thymidylate Synthase; Tyrosine | 1997 |
Modeling of reaction steps relevant to deoxyuridylate (dUMP) enzymatic methylation and thymidylate synthase mechanism-based inhibition.
Topics: Algorithms; Cysteine; Deoxycytidine Monophosphate; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Methylation; Models, Chemical; Quantum Theory; Sulfhydryl Compounds; Tetrahydrofolates; Thymidylate Synthase; Uracil; Water | 1998 |
Aspartate 221 of thymidylate synthase is involved in folate cofactor binding and in catalysis.
Topics: Aspartic Acid; Binding Sites; Catalysis; Coenzymes; Deoxyuracil Nucleotides; Escherichia coli; Fluorodeoxyuridylate; Genetic Complementation Test; Halogens; Kinetics; Lacticaseibacillus casei; Mutagenesis, Insertional; Tetrahydrofolates; Thymidine Monophosphate; Thymidylate Synthase | 1998 |
D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine.
Topics: Asparagine; Aspartic Acid; Binding Sites; Crystallography, X-Ray; Escherichia coli; Fluorodeoxyuridylate; Folic Acid; Hydrogen Bonding; Imidazoles; Macromolecular Substances; Models, Molecular; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Quinazolines; Substrate Specificity; Tetrahydrofolates; Thymidylate Synthase | 1998 |
Drug-resistant variants of Escherichia coli thymidylate synthase: effects of substitutions at Pro-254.
Topics: Amino Acid Substitution; Crystallography, X-Ray; Deoxyuracil Nucleotides; Drug Resistance; Drug Resistance, Microbial; Enzyme Inhibitors; Escherichia coli; Fluorodeoxyuridylate; Folic Acid Antagonists; Humans; Kinetics; Mutation; Proline; Protein Conformation; Quinazolines; Tetrahydrofolates; Thymidylate Synthase; Transfection | 2000 |
Probing the role of parasite-specific, distant structural regions on communication and catalysis in the bifunctional thymidylate synthase-dihydrofolate reductase from Plasmodium falciparum.
Topics: Animals; Catalysis; Enzyme Activation; Fluorodeoxyuridylate; Kinetics; Leishmania major; Models, Molecular; Multienzyme Complexes; Plasmodium falciparum; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thymidylate Synthase | 2008 |
Isolation of a homogeneous preparation of human thymidylate synthetase from HeLa cells.
Topics: Fluorodeoxyuridylate; HeLa Cells; Humans; Protein Binding; Tetrahydrofolates; Thymidylate Synthase | 1980 |