fluorodeoxyuridylate has been researched along with 2'-deoxyuridylic acid in 36 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (38.89) | 18.7374 |
| 1990's | 13 (36.11) | 18.2507 |
| 2000's | 8 (22.22) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (2.78) | 2.80 |
| Authors | Studies |
|---|---|
| Hansch, C; Santi, DV; Wataya, Y | 1 |
| Nakayama, C; Saneyoshi, M; Santi, DV; Ueda, T; Wataya, Y | 1 |
| Herdewijn, P; Munier-Lehmann, H; Pochet, S; Van Calenbergh, S; Vanheusden, V | 1 |
| Herdewijn, P; Munier-Lehmann, H; Pochet, S; Van Calenbergh, S; Van Rompaey, P; Vanheusden, V | 1 |
| Chen, TL; Erlichman, C | 1 |
| Laurensse, EJ; Peters, GJ; Pinedo, HM; van Groeningen, CJ | 1 |
| Bretner, M; Cieśla, J; Dzik, JM; Kierdaszuk, B; Kulikowski, T; Rode, W; Shugar, D; Zieliński, Z | 1 |
| Cisneros, RJ; Deng, WL; Dunlap, RB; Johnson, LF; Zhang, HC | 1 |
| Danenberg, PV; Frösing, R; Gustavsson, BG; Hayes, AA; Shahinian, AH; Spears, CP | 1 |
| Houghton, JA; Houghton, PJ; Torrance, PM; Weiss, KD; Williams, LG | 1 |
| Mittelstaedt, DM; Schimerlik, MI | 1 |
| Gustavsson, BG; Spears, CP | 1 |
| Berne, M; Bernstein, L; Frösing, R; Gustavsson, BG; Hayes, AA; Spears, CP | 1 |
| Carlsson, G; Frösing, R; Gustavsson, BG; Spears, CP | 1 |
| Dallas, WS; Dev, IK; Leong, J; Yates, BB | 1 |
| Garvey, EP; Santi, DV | 1 |
| Ahmed, F; Dunlap, RB; Moore, MA | 1 |
| Kedzierska, B; Kulikowski, T; Rode, W; Shugar, D | 1 |
| Chabner, BA; Donehower, RC; Liang, CM | 1 |
| Heidelberger, C | 1 |
| Allegra, CJ; Drake, JC; Glennon, MC; Johnston, PG; Kinsella, TJ; McGinn, CJ; Pestalozzi, BC | 1 |
| Connick, TJ; Dunlap, RB; Ellis, PD; Reilly, RT | 1 |
| Appley, MI; Aull, JL; Daron, HH | 1 |
| Bretner, M; Dzik, JM; Gołos, B; Jarmuła, A; Kulikowski, T; Poznański, J; Rode, W; Shugar, D | 1 |
| Leś, A; Rode, W | 1 |
| Rode, W | 1 |
| Adamowicz, L; Leś, A; Rode, W | 1 |
| Csapó, Z; Keszler, G; Noordhuis, P; Peters, GJ; Sasvári-Székely, M; Smid, K; Staub, M | 1 |
| Chiericatti, G; Santi, DV | 1 |
| Berger, FG; Fantz, C; Forsthoefel, A; Jennings, W; Kitchens, M; Lebioda, L; Minor, W; Phan, J; Shaw, D; Spencer, HT | 1 |
| Dix, D; Dunlap, RB; Felder, T; Spencer, T | 1 |
| Cieplak, P; Jarmuła, A; Leś, A; Rode, W | 1 |
| Abrowska, MD; Cieśla, J; Jagielska, E; Maley, F; Rode, W; Skopiński, T | 1 |
| Cieśla, J; Felczak, K; Kulikowski, T; Poznański, J; Rode, W; Zieliński, Z; Ziemkowski, P | 1 |
| Carli, D; Cohen, S; Dumontet, C; Guitton, J; Honorat, M; Megherbi, M; Payen, L; Vignal, B | 1 |
| Casamayou-Boucau, Y; Cieśla, J; Fita, P; Gordon, F; Jarmuła, A; Maj, P; Prokopowicz, M; Rode, W; Ryder, A; Sobich, J; Zieliński, Z | 1 |
2 review(s) available for fluorodeoxyuridylate and 2'-deoxyuridylic acid
| Article | Year |
|---|---|
Molecular mechanism of thymidylate synthase-catalyzed reaction and interaction of the enzyme with 2- and/or 4-substituted analogues of dUMP and 5-fluoro-dUMP.
Topics: Animals; Antifungal Agents; Antineoplastic Agents; Antiprotozoal Agents; Antiviral Agents; Deoxyuracil Nucleotides; Drug Design; Fluorodeoxyuridylate; Humans; Hydrogen Bonding; Molecular Structure; Thymidine Kinase | 1996 |
[Inhibition of thymidylate synthase in chemotherapy].
Topics: Animals; Antineoplastic Agents; Cell Cycle; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Humans; Substrate Specificity; Thymidylate Synthase; Thymine Nucleotides | 1996 |
34 other study(ies) available for fluorodeoxyuridylate and 2'-deoxyuridylic acid
| Article | Year |
|---|---|
Inhibition of Lactobacillus casei thymidylate synthetase by 5-substituted 2'-deoxyuridylates. Preliminary quantitative structure-activity relationship.
Topics: Deoxyuracil Nucleotides; Kinetics; Lacticaseibacillus casei; Methyltransferases; Structure-Activity Relationship; Thymidylate Synthase | 1977 |
Interaction of 1-(5-phospho-beta-D-arabinofuranosyl)-5-substituted-uracils with thymidylate synthetase: mechanism-based inhibition by 1-(5-phospho-beta-D-arabinosyl)-5-fluorouracil.
Topics: Arabinonucleotides; Fluorouracil; Kinetics; Methyltransferases; Structure-Activity Relationship; Thymidylate Synthase | 1981 |
Synthesis and evaluation of thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.
Topics: Antitubercular Agents; Crystallography, X-Ray; Enzyme Inhibitors; Kinetics; Models, Molecular; Mycobacterium tuberculosis; Nucleoside-Phosphate Kinase; Thymidine Monophosphate | 2002 |
Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.
Topics: Antitubercular Agents; Enzyme Inhibitors; Inhibitory Concentration 50; Kinetics; Mycobacterium tuberculosis; Nucleoside-Phosphate Kinase; Structure-Activity Relationship; Thymidine; Thymine Nucleotides | 2003 |
Biochemical modulation of 5-fluorouracil with or without leucovorin by a low dose of brequinar in MGH-U1 cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biphenyl Compounds; Cell Survival; Cytidine Triphosphate; Deoxyuracil Nucleotides; Dose-Response Relationship, Drug; Drug Interactions; Fluorodeoxyuridylate; Fluorouracil; Humans; Hypoxanthine; Hypoxanthines; Leucovorin; Phosphoribosyl Pyrophosphate; Thymidylate Synthase; Tumor Cells, Cultured; Uridine Triphosphate | 1992 |
Thymidylate synthase from untreated human colorectal cancer and colonic mucosa: enzyme activity and inhibition by 5-fluoro-2'-deoxy-uridine-5'-monophosphate.
Topics: Aged; Aged, 80 and over; Binding Sites; Colon; Colonic Neoplasms; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Humans; Intestinal Mucosa; Middle Aged; Rectal Neoplasms; Thymidylate Synthase | 1991 |
Mechanism of inhibition of mammalian tumor and other thymidylate synthases by N4-hydroxy-dCMP, N4-hydroxy-5-fluoro-dCMP, and related analogues.
Topics: Animals; Binding Sites; Binding, Competitive; Carcinoma, Ehrlich Tumor; Deoxycytidine Monophosphate; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Hymenolepis; Kinetics; Leukemia L1210; Liver; Liver Regeneration; Mice; Neoplasms, Experimental; Rats; Thymidylate Synthase; Tumor Cells, Cultured | 1990 |
Site-directed mutagenesis of mouse thymidylate synthase: alteration of Arg44 to Val44 in a conserved loop guarding the active site has striking effects on catalysis and nucleotide binding.
Topics: Amino Acid Sequence; Animals; Arginine; Base Sequence; Binding Sites; Catalysis; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Hydrogen Bonding; Kinetics; Mice; Molecular Sequence Data; Mutation; Oligonucleotide Probes; Plasmids; Protein Conformation; Thymidylate Synthase; Valine | 1990 |
Deoxyuridylate effects on thymidylate synthase-5-fluorodeoxyuridylate-folate ternary complex formation.
Topics: Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Folic Acid; Kinetics; Thymidylate Synthase | 1989 |
Relationship between 5-fluoro-2'-deoxyuridylate, 2'-deoxyuridylate, and thymidylate synthase activity subsequent to 5-fluorouracil administration, in xenografts of human colon adenocarcinomas.
Topics: Adenocarcinoma; Adenosine Monophosphate; Animals; Cell Line; Colonic Neoplasms; Deoxyuracil Nucleotides; Drug Resistance; Fluorodeoxyuridylate; Fluorouracil; Humans; Hydrogen-Ion Concentration; Mice; Neoplasm Transplantation; Phosphoric Monoester Hydrolases; Thymidylate Synthase; Transplantation, Heterologous | 1986 |
Stopped-flow studies of 2'-deoxynucleotide binding to thymidylate synthase.
Topics: Binding Sites; Deoxyribonucleotides; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Kinetics; Lacticaseibacillus casei; Mathematics; Models, Chemical; Protein Binding; Protein Conformation; Spectrometry, Fluorescence; Thermodynamics; Thymidine Monophosphate; Thymidylate Synthase | 1986 |
Methods for thymidylate synthase pharmacodynamics: serial biopsy, free and total TS, FdUMP and dUMP, and H4PteGlu and CH2-H4PteGlu assays.
Topics: Biopsy, Needle; Cytosol; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Humans; Lacticaseibacillus casei; Neoplasms; Radioisotope Dilution Technique; Tetrahydrofolates; Thymidylate Synthase; Tritium | 1988 |
Mechanisms of innate resistance to thymidylate synthase inhibition after 5-fluorouracil.
Topics: Adenocarcinoma; Breast Neoplasms; Colonic Neoplasms; Deoxyuracil Nucleotides; Drug Resistance; Fluorodeoxyuridylate; Fluorouracil; Humans; Pancreatic Neoplasms; Stomach Neoplasms; Thymidylate Synthase | 1988 |
Pharmacodynamics of 5-fluorouracil and leucovorin.
Topics: Adenocarcinoma; Animals; Bone Marrow; Colonic Neoplasms; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Fluorouracil; Humans; Intestinal Mucosa; Leucovorin; Liver; Pancreatic Neoplasms; Rats; Rats, Inbred Strains; Rectal Neoplasms; Stomach Neoplasms; Thymidylate Synthase | 1988 |
Functional role of cysteine-146 in Escherichia coli thymidylate synthase.
Topics: Catalysis; Cysteine; Deoxyuracil Nucleotides; DNA Mutational Analysis; Escherichia coli; Fluorodeoxyuridylate; Glycine; Kinetics; Pteroylpolyglutamic Acids; Structure-Activity Relationship; Substrate Specificity; Thymidylate Synthase | 1988 |
A stable binary complex between Leishmania major thymidylate synthase and the substrate deoxyuridylate. A slow-binding interaction.
Topics: Animals; Binding, Competitive; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Folic Acid; Kinetics; Leishmania tropica; Quinazolines; Thymidine Monophosphate; Thymidylate Synthase | 1987 |
Evidence for the existence of covalent nucleotide-thymidylate synthase complexes, identification of site of attachment, and enhancement by folates.
Topics: Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Folic Acid; Tetrahydrofolates; Thymidine Monophosphate; Thymidylate Synthase | 1986 |
Studies on the interaction with thymidylate synthase of analogues of 2'-deoxyuridine-5'-phosphate and 5-fluoro-2'-deoxyuridine-5'-phosphate with modified phosphate groups.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Line; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Kinetics; Mice; Structure-Activity Relationship; Thymidylate Synthase | 1987 |
Biochemical interactions between N-(phosphonacetyl)-L-aspartate and 5-fluorouracil.
Topics: Animals; Aspartic Acid; Cells, Cultured; Deoxyuracil Nucleotides; Drug Interactions; Fluorodeoxyuridylate; Fluorouracil; Kinetics; Lacticaseibacillus casei; Mice; Organophosphorus Compounds; Phosphonoacetic Acid; Sarcoma 180; Thymidylate Synthase | 1982 |
On the rational development of a new drug: the example of the fluorinated pyrimidines.
Topics: Animals; Antimetabolites, Antineoplastic; Biotransformation; Deoxyuracil Nucleotides; DNA, Neoplasm; Fluorodeoxyuridylate; Fluorouracil; Humans; RNA, Neoplasm; Thymidylate Synthase | 1981 |
Increased thymidylate synthase protein levels are principally associated with proliferation but not cell cycle phase in asynchronous human cancer cells.
Topics: Breast Neoplasms; Cell Cycle; Cell Division; Cell Line; Colonic Neoplasms; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Humans; Kinetics; Thymidylate Synthase; Time Factors; Tumor Cells, Cultured | 1995 |
Phosphorus-31 nuclear magnetic resonance studies of complexes of thymidylate synthase.
Topics: Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Folic Acid; Magnetic Resonance Spectroscopy; Phosphorus Isotopes; Quinazolines; Tetrahydrofolates; Thymidine Monophosphate; Thymidylate Synthase | 1994 |
Interaction of pyridoxal phosphate with thymidylate synthase: spectral and equilibrium dialysis studies.
Topics: Binding Sites; Deoxyuracil Nucleotides; Dialysis; Fluorodeoxyuridylate; Pyridoxal Phosphate; Spectrophotometry, Ultraviolet; Thymidine Monophosphate; Thymidylate Synthase | 1993 |
Synthesis and interactions with thymidylate synthase of 2,4-dithio analogues of dUMP and 5-fluoro-dUMP.
Topics: Animals; Binding Sites; Cell Division; Deoxyuracil Nucleotides; Drug Resistance, Neoplasm; Enzyme Inhibitors; Floxuridine; Fluorodeoxyuridylate; Kinetics; Leukemia L1210; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Structure; Phosphorylation; Phosphotransferases; Protein Binding; Thionucleotides; Thymidylate Synthase; Tumor Cells, Cultured | 1996 |
Modeling of reaction steps relevant to deoxyuridylate (dUMP) enzymatic methylation and thymidylate synthase mechanism-based inhibition.
Topics: Algorithms; Cysteine; Deoxycytidine Monophosphate; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Methylation; Models, Chemical; Quantum Theory; Sulfhydryl Compounds; Tetrahydrofolates; Thymidylate Synthase; Uracil; Water | 1998 |
Similar changes were induced by Cladribine and by gemcitabine, in the deoxypyrimidine salvage, during short-term treatments.
Topics: Antimetabolites, Antineoplastic; Cell Line; Cladribine; DCMP Deaminase; Deoxycytidine; Deoxycytidine Kinase; Deoxyuracil Nucleotides; Enzyme Inhibitors; Fluorodeoxyuridylate; Gemcitabine; Humans; In Vitro Techniques; Kinetics; Lymphocytes; Palatine Tonsil; Thymidine; Thymidine Kinase | 1998 |
Aspartate 221 of thymidylate synthase is involved in folate cofactor binding and in catalysis.
Topics: Aspartic Acid; Binding Sites; Catalysis; Coenzymes; Deoxyuracil Nucleotides; Escherichia coli; Fluorodeoxyuridylate; Genetic Complementation Test; Halogens; Kinetics; Lacticaseibacillus casei; Mutagenesis, Insertional; Tetrahydrofolates; Thymidine Monophosphate; Thymidylate Synthase | 1998 |
Drug-resistant variants of Escherichia coli thymidylate synthase: effects of substitutions at Pro-254.
Topics: Amino Acid Substitution; Crystallography, X-Ray; Deoxyuracil Nucleotides; Drug Resistance; Drug Resistance, Microbial; Enzyme Inhibitors; Escherichia coli; Fluorodeoxyuridylate; Folic Acid Antagonists; Humans; Kinetics; Mutation; Proline; Protein Conformation; Quinazolines; Tetrahydrofolates; Thymidylate Synthase; Transfection | 2000 |
Differences in natural ligand and fluoropyrimidine binding to human thymidylate synthase identified by transient-state spectroscopic and continuous variation methods.
Topics: Binding Sites; Deoxyuracil Nucleotides; Fluorescence; Fluorodeoxyuridylate; Humans; Kinetics; Ligands; Protein Binding; Pyrimidines; Spectrophotometry; Thermodynamics; Thymidylate Synthase | 2002 |
Relative free energies of binding to thymidylate synthase of 2- and/or 4-thio and/or 5-fluoro analogues of dUMP.
Topics: Binding Sites; Computer Simulation; Deoxyuracil Nucleotides; Escherichia coli; Fluorodeoxyuridylate; Hydrogen Bonding; Models, Molecular; Molecular Conformation; Molecular Structure; Protein Binding; Thermodynamics; Thymidylate Synthase | 2003 |
Binding and repression of translation of the cognate mRNA by Trichinella spiralis thymidylate synthase differ from the corresponding interactions of the human enzyme.
Topics: Animals; Chickens; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Gene Expression Regulation, Enzymologic; Humans; Mercaptoethanol; Protein Binding; Protein Biosynthesis; RNA, Messenger; Species Specificity; Tetrahydrofolates; Thymidylate Synthase; Trichinella spiralis | 2005 |
Interactions of 2'-fluoro-substituted dUMP analogues with thymidylate synthase.
Topics: Carbohydrates; Cysteine; Deoxyuracil Nucleotides; Fluorine; Fluorodeoxyuridylate; Furans; Glycosides; Humans; Kinetics; Magnetic Resonance Spectroscopy; Models, Chemical; Molecular Conformation; Recombinant Proteins; Sulfhydryl Compounds; Thymidylate Synthase | 2007 |
Simultaneous quantification of 5-FU, 5-FUrd, 5-FdUrd, 5-FdUMP, dUMP and TMP in cultured cell models by LC-MS/MS.
Topics: Cell Line; Cell Line, Tumor; Chromatography, Liquid; Deoxyuracil Nucleotides; Drug Stability; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Tandem Mass Spectrometry; Thymidine Monophosphate | 2009 |
Advanced Spectroscopy and APBS Modeling for Determination of the Role of His190 and Trp103 in Mouse Thymidylate Synthase Interaction with Selected dUMP Analogues.
Topics: Amino Acid Substitution; Animals; Deoxycytidine Monophosphate; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Mice; Models, Molecular; Models, Theoretical; Multivariate Analysis; Protein Conformation; Spectrometry, Fluorescence; Static Electricity; Thymidylate Synthase | 2021 |