fluorine has been researched along with piperidines in 60 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 44 (73.33) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 5 (8.33) | 29.6817 |
2010's | 10 (16.67) | 24.3611 |
2020's | 1 (1.67) | 2.80 |
Authors | Studies |
---|---|
Hopkała, H; Przyborowski, L | 1 |
a'Brook, MF; Tarighati, S | 1 |
Monti, JM | 1 |
Broomfield, CA; Hackley, BE; Morrisett, JD | 1 |
Berliner, LJ | 1 |
Nixon, R | 1 |
Broomfield, CA; Morrisett, JD | 1 |
Leterrier, F; Mariaud, JF; Rieger, F | 1 |
Berliner, LJ; Wong, SS | 1 |
Berliner, LJ; Quiggle, K; Triplett, C; Wong, SS | 1 |
Gary-Bobo, CM; Riguad, JL; Taupin, C | 1 |
Draper, MD; Klohs, MW; Levy, L; McClure, DA; Petracek, FJ; Ré, ON | 1 |
Williams, CH | 1 |
Airoldi, L; Garattini, S; Marcucci, F; Mussini, E | 1 |
Tobin, JM | 1 |
Hádlík, J; Misurec, J; Náhunek, K; Rodová, A; Vanýsek, J | 1 |
Náhunek, K; Svestka, J | 1 |
Clark, ML; Colmore, JP; Huber, WK; Kyriakopoulos, AA; Ramsey, HR; Ray, TS | 2 |
Dolan, WM; Eger, EI; Miller, RD; Stevens, WC; Way, WL | 1 |
Lutz, RE; Ohnmacht, CJ; Patel, AR | 1 |
Chin, CG; Micetich, RG; Raap, R | 1 |
Assis, LM; Martins, C; Navarro, MP | 1 |
Szobor, A | 1 |
Hádlik, J; Náhunek, K; Rodová, A; Svestka, J; Vanýsek, J | 1 |
Janssen, PA; Niemegeers, CJ; Verbruggen, FJ | 3 |
Farcasanu, M; Maniu, M; Uray, Z | 1 |
Heykants, JJ; Janssen, PA; Lewi, PJ | 1 |
Petri, G; Porszasz-Gibiszer, K; Szenohradszky, J | 1 |
Acebal, EM; Spatz, H | 1 |
Bordeleau, JM; Gauthier, R; Hillel, J; Tétreault, L | 1 |
Burger, A; Pinder, RM | 1 |
Le Vann, LJ | 1 |
Ezhkov, AA | 1 |
Kristjansen, P | 1 |
Gatti, GL; Michalek, H; Pocchiari, F | 1 |
Bordeleau, JM; Filotto, J; Tetreault, L | 1 |
Frosali, L; Gigli, M; Salvini, L | 1 |
Fink, M; Itil, T | 1 |
Gatti, G; Michalek, H; Pocchiari, F | 1 |
Hance, AJ; Monti, JM | 1 |
Bohanon, MJ; Boyle, TP; Heckaman, CL; Marotti, KR; Presley-Bodnar, AL; Sweeney, MT; Thorarensen, A; Tomich, PK; Yagi, BH; Zurenko, GE | 1 |
Hammond, PS; Huang, Y; Mach, RH; Wu, L | 1 |
Hardcastle, K; Lankin, DC; Snyder, JP; Sun, A | 1 |
Ishiwata, K; Maeda, M; Mukai, T; Nojiri, Y; Sasada, T; Tobiishi, S; Yamamoto, F | 1 |
Crich, D; Vinogradova, O | 1 |
Andrade, P; Angagaw, M; Bi, G; Black, RM; Crispino, J; Cruz, JC; Fan, E; Farris, G; Hamblett, C; Hubbs, J; Hughes, BL; Kenific, CM; Middleton, RE; Munoz, B; Nikov, G; Sajonz, P; Shah, S; Shearman, M; Shomer, N; Sloman, D; Stanton, MG; Szewczak, AA; Tanga, F; Tudge, MT | 1 |
De Kimpe, N; Deroose, F; Macdonald, G; Piron, K; Thuring, JW; Van Hende, E; Verniest, G | 1 |
Bernabè, E; Castoldi, D; Cimarosti, Z; Curcuruto, O; Dams, R; Marchioro, C; Martini, L; Nicoletti, A; Papini, D; Provera, S; Turco, L | 1 |
Chonan, T; Hiratate, A; Io, F; Koretsune, H; Ohoka-Sugita, A; Oi, T; Tanaka, H; Wakasugi, D; Yamamoto, D; Yashiro, M | 1 |
Abrol, R; Goddard, WA; Kudo, W; Nair, N; Reddy, VP; Smith, MA | 1 |
Matsuura, K; Ohta, M; Okada, M; Okazaki, T; Tomura, Y; Tsukamoto, S; Watanuki, S | 1 |
D'hooghe, M; De Kimpe, N; Dolfen, J; Kenis, S; Van Hecke, K | 1 |
Khosravan, A; Marani, S; Sadeghi Googheri, MS | 1 |
Carreira, EM; Müller, K; Vorberg, R | 1 |
Altomare, CD; de Candia, M; Denora, N; Jung, JH; Kim, SE; Lee, BC; Moon, BS; Park, DD; Park, HS | 1 |
Imae, T; Krathumkhet, N; Ujihara, M | 1 |
5 trial(s) available for fluorine and piperidines
Article | Year |
---|---|
Management of the schizophrenic patient in a community psychiatric practice.
Topics: Acute Disease; Adolescent; Adult; Aged; Antidepressive Agents; Butyrophenones; Chronic Disease; Clinical Trials as Topic; Community Mental Health Services; Female; Fluorine; Humans; Male; Middle Aged; Piperidines; Schizophrenia; Trifluperidol | 1968 |
[Comparison of triperidol with perphenazine in schizophrenic psychoses. Effect on the photomyoclonic threshold].
Topics: Adolescent; Adult; Antidepressive Agents; Butyrophenones; Clinical Trials as Topic; Depressive Disorder, Major; Female; Fluorine; Humans; Light; Male; Middle Aged; Myoclonus; Perphenazine; Piperidines; Placebos; Reflex; Schizophrenia; Trifluperidol | 1970 |
[Controlled comparative study of methylperidol and perphenazine in schizoprenic psychoses].
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Butyrophenones; Clinical Trials as Topic; Female; Fluorine; Humans; Middle Aged; Perphenazine; Piperidines; Placebos; Schizophrenia | 1970 |
Evaluation of trifluperidol in chronic schizophrenia.
Topics: Adult; Age Factors; Antidepressive Agents; Butyrophenones; Chronic Disease; Clinical Trials as Topic; Female; Fluorine; Hospitalization; Humans; Middle Aged; Piperidines; Placebos; Schizophrenia; Trifluperidol | 1968 |
Evaluation of trifluperidol in chronic schizaphrenia.
Topics: Adult; Antidepressive Agents; Butyrophenones; Chlorpromazine; Chronic Disease; Clinical Trials as Topic; Female; Fluorine; Humans; Middle Aged; Piperidines; Placebos; Schizophrenia; Trifluperidol | 1968 |
55 other study(ies) available for fluorine and piperidines
Article | Year |
---|---|
Determination of drugs containing fluorine with ion-selective electrode. Part 2: Butyrophenones and bis(4-fluorophenyl)butylpiperidines.
Topics: Butyrophenones; Electrodes; Fluorine; Penfluridol; Pimozide; Piperidines; Potentiometry; Spectrophotometry, Ultraviolet | 1989 |
Trifluperidol in Huntington's chorea.
Topics: Aged; Antidepressive Agents; Butyrophenones; Fluorine; Humans; Huntington Disease; Middle Aged; Piperidines; Trifluperidol | 1968 |
Effects of haloperidol and trifluperidol on the sleep cycle of the cat.
Topics: Animals; Antidepressive Agents; Butyrophenones; Cats; Cerebral Cortex; Fluorine; Haloperidol; Muscles; Piperidines; Sleep; Sleep Stages; Sleep, REM; Trifluperidol; Wakefulness | 1970 |
A new spin label specific for the active site of serine enzymes.
Topics: Acetylcholinesterase; Animals; Binding Sites; Brain Chemistry; Cattle; Cell Membrane; Chemical Phenomena; Chemistry; Chymotrypsin; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Erythrocytes; Fluorine; Free Radicals; Humans; Nerve Endings; Organophosphonates; Piperidines; Rats; Serine | 1969 |
Urea denaturation of active-site spin-labeled -chymotrypsin.
Topics: Binding Sites; Chymotrypsin; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Fluorine; Hydrogen-Ion Concentration; Organophosphorus Compounds; Piperidines; Protein Denaturation; Pyrroles; Urea | 1972 |
Volatile amines in mouse brain: a radioassay with picogram sensitivity.
Topics: Amines; Animals; Brain Chemistry; Chromatography, Thin Layer; Ethanol; Fluorine; Mathematics; Methods; Mice; Mice, Inbred Strains; Microchemistry; Nitrobenzenes; Perchlorates; Picrates; Piperidines; Pyrrolidines; Radiochemistry; Solvents; Trichloroacetic Acid; Tritium | 1972 |
A comparative study of spin-labeled serine enzymes: acetylcholinesterase, trypsin, -chymotrypsin, elastase, and subtilisin.
Topics: Acetylcholinesterase; Binding Sites; Chymotrypsin; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Endopeptidases; Fluorine; Hydrogen-Ion Concentration; Indicators and Reagents; Organophosphorus Compounds; Pancreatic Elastase; Piperidines; Protein Binding; Serine; Subtilisins; Trypsin | 1972 |
Comparative study of the action of phenothiazine and para-fluorobutyrophenone derivatives on rat brain membranes using the spin label technique.
Topics: Animals; Brain; Butyrophenones; Cerebral Cortex; Cyclic N-Oxides; Dimethyl Sulfoxide; Electron Spin Resonance Spectroscopy; Erythrocytes; Fluorine; Male; Maleimides; Membranes; Myelin Sheath; Phenothiazines; Piperidines; Rats; Synaptosomes | 1973 |
Spin-labeled sulfonyl fluorides as active site probes of protease structure. I. Comparison of the active site environments in alpha-chymotrypsin and trypsin.
Topics: Amidines; Benzene Derivatives; Benzenesulfonates; Binding Sites; Chemical Phenomena; Chemistry; Chymotrypsin; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Fluorine; Hydrogen-Ion Concentration; Indoles; Isomerism; Models, Structural; Piperidines; Protein Conformation; Pyrroles; Pyrrolidines; Structure-Activity Relationship; Tosyl Compounds; Trypsin; Trypsin Inhibitors | 1974 |
Spin-labeled sulfonyl fluorides as active site probes of protease structure. II. Spin label syntheses and enzyme inhibition.
Topics: Benzenesulfonates; Binding Sites; Chymotrypsin; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Evaluation Studies as Topic; Fluorine; Hydrolysis; Methods; Piperidines; Structure-Activity Relationship; Time Factors; Tosyl Compounds; Trypsin; Trypsin Inhibitors | 1974 |
Effect of chemical modifiers of passive permeability on the conformation of spin-labeled erythrocyte membranes.
Topics: Benzenesulfonates; Cell Membrane Permeability; Chloromercuribenzoates; Electron Spin Resonance Spectroscopy; Erythrocytes; Ethylmaleimide; Fluorine; Humans; Hydrogen-Ion Concentration; Iodoacetates; Maleimides; Mercury; Molecular Conformation; Nitrobenzenes; Organometallic Compounds; Osmolar Concentration; Piperidines; Protein Binding; Spin Labels; Stearic Acids; Sulfhydryl Compounds; Temperature; Time Factors; Tropanes | 1974 |
Fluorophenyl-4-(p-fluorophenyl)-4-hydroxy-1-methyl-3-piperidyl ketone (flazalone): a novel non-steroidal anti-inflammatory agent.
Topics: Administration, Oral; Analgesics; Anaphylaxis; Animals; Anti-Inflammatory Agents; Arthritis; Edema; Fever; Fluorine; Graft Rejection; Humans; Ketones; Mice; Piperidines; Rabbits; Rats | 1972 |
Monoamine oxidase. I. Specificity of some substrates and inhibitors.
Topics: Amines; Amphetamine; Animals; Benzyl Compounds; Brain; Cyclohexylamines; Fluorine; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Mitochondria; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nerve Tissue Proteins; Oxidation-Reduction; Oximes; Phenethylamines; Phenylbutyrates; Phenylpropanolamine; Piperidines; Potentiometry; Swine; Tyramine | 1974 |
Distribution of penfluridol in rats and mice.
Topics: Adipose Tissue; Animals; Brain; Cerebellum; Chromatography, Gas; Corpus Striatum; Dextroamphetamine; Diencephalon; Fluorine; Humans; Hydrocarbons, Halogenated; Male; Mesencephalon; Mice; Piperidines; Rats; Stereotyped Behavior; Time Factors; Toluene; Tranquilizing Agents | 1974 |
Comparative neuromuscular effects of pancuronium, gallamine, and succinylcholine during forane and halothane anesthesia in man.
Topics: Adult; Aged; Androstanes; Anesthesia, Inhalation; Chlorine; Drug Synergism; Electric Stimulation; Ethers; Fluorine; Gallamine Triethiodide; Halothane; Humans; Hydrocarbons, Halogenated; Injections, Intravenous; Middle Aged; Muscles; Piperidines; Succinylcholine; Ulnar Nerve | 1971 |
Antimalarials. 7. Bis(trifluoromethyl)- -(2-piperidyl)-4-quinolinemethanols.
Topics: Animals; Antimalarials; Fluorine; Malaria; Methanol; Mice; Piperidines; Quinolines; Spectrum Analysis; Time Factors; Ultraviolet Rays | 1971 |
Studies in isoxazole chemistry. 5. N-alkylation and N-acylation of 5-amino-3-(5-nitro-2-furyl)isoxazoles.
Topics: Acetamides; Allyl Compounds; Amides; Amines; Animals; Bacteria; Carbamates; Carboxylic Acids; Chlorine; Fluorine; Furans; Morpholines; Nitriles; Nitro Compounds; Oxazoles; Piperidines; Structure-Activity Relationship; Trichomonas | 1971 |
[Clinical results with trifluoperidol in schizophrenic patients].
Topics: Adolescent; Adult; Antidepressive Agents; Butyrophenones; Fluorine; Humans; Male; Piperidines; Schizophrenia; Trifluperidol | 1966 |
Results of trifluperidol therapy.
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Butyrophenones; Fluorine; Haloperidol; Humans; Mental Disorders; Middle Aged; Piperidines; Trifluperidol | 1969 |
[Comparison of the therapeutic effect of triperidol with perphenazine in schizophrenia].
Topics: Adolescent; Adult; Antidepressive Agents; Butyrophenones; Female; Fluorine; Humans; Male; Middle Aged; Perphenazine; Piperidines; Schizophrenia; Trifluperidol | 1969 |
The influence of various neuroleptic drugs on shock avoidance responding in rats. I. Nondiscriminated Sidman avoidance procedure.
Topics: Animals; Antidepressive Agents; Avoidance Learning; Benperidol; Benzimidazoles; Butyrophenones; Chlorpromazine; Depression, Chemical; Electroshock; Escape Reaction; Female; Fluorine; Fluphenazine; Haloperidol; Isonipecotic Acids; Perphenazine; Piperidines; Promazine; Rats; Spiro Compounds; Thioridazine; Tranquilizing Agents; Trifluoperazine | 1969 |
The influence of various neuroleptic drugs on shock avoidance responding in rats. II. Nondiscriminated Sidman avoidance procedure with alternate reinforcement and extinction periods and analysis of the interresponse times (IRT's).
Topics: Animals; Antidepressive Agents; Avoidance Learning; Benperidol; Blepharoptosis; Butyrophenones; Catalepsy; Chlorpromazine; Depression, Chemical; Electroshock; Escape Reaction; Extinction, Psychological; Female; Fluorine; Haloperidol; Humans; Piperidines; Rats; Reinforcement, Psychology; Time Factors; Tranquilizing Agents; Trifluperidol | 1969 |
[Radioprotective properties of butyrophenone derivatives].
Topics: Animals; Antidepressive Agents; Benperidol; Butyrophenones; Fluorine; Haloperidol; Iron Isotopes; Male; Mice; Piperidines; Radiation Injuries, Experimental; Radiation Protection; Radiation-Protective Agents; Trifluperidol | 1970 |
The influence of various neuroleptic drugs on noise escape response in rats.
Topics: Animals; Antidepressive Agents; Avoidance Learning; Benperidol; Blepharoptosis; Butyrophenones; Catalepsy; Chlorpromazine; Escape Reaction; Female; Fluorine; Fluphenazine; Haloperidol; Humans; Noise; Perphenazine; Piperidines; Rats; Spiro Compounds; Thioridazine; Tranquilizing Agents; Trifluoperazine; Triflupromazine | 1970 |
On the distribution and metabolism of neuroleptic drugs. 3. Pharmacokinetics of trifluperidol.
Topics: Animals; Antidepressive Agents; Brain; Butyrophenones; Feces; Fluorine; Liver; Piperidines; Rats; Trifluperidol; Tritium | 1970 |
Sympatholytic treatment of "paralytic" ileus.
Topics: Antidepressive Agents; Butyrophenones; Carbamates; Catecholamines; Chlorpromazine; Diagnosis, Differential; Drug Synergism; Fluorine; Gastrointestinal Diseases; Gastrointestinal Motility; Humans; Ileum; Intestinal Diseases; Neostigmine; Paralysis; Piperidines; Pyridinium Compounds; Trifluperidol | 1971 |
Effect of trifluperidol (R 2498) on the urinary elimination of bufotenin in schizophrenia.
Topics: Adolescent; Adult; Antidepressive Agents; Butyrophenones; Convulsive Therapy; Electroconvulsive Therapy; Fluorine; Hallucinogens; Humans; Male; Piperidines; Schizophrenia; Trifluperidol | 1967 |
[Comparative study of trifluperidol and trifluoperazine in the treatment of acute schizophrenia].
Topics: Antidepressive Agents; Butyrophenones; Chlorpromazine; Female; Fluorine; Humans; Male; Middle Aged; Piperidines; Schizophrenia; Trifluoperazine | 1967 |
Antimalarials. II. Alpha-(2-piperidyl)-and alpha-(2-pyridyl)-2-trifluoromethyl-4-quinolinemethanols.
Topics: Animals; Antimalarials; Fluorine; Mice; Photosensitivity Disorders; Piperidines; Plasmodium; Pyridines; Quinolines | 1968 |
A new butyrophenone: trifluperidol. A psychiatric evaluation in a pediatric setting.
Topics: Adolescent; Antidepressive Agents; Aspartate Aminotransferases; Attention; Brain Damage, Chronic; Butyrophenones; Child; Child Behavior Disorders; Child, Preschool; Fluorine; Humans; Piperidines; Psychotic Disorders; Schizophrenia, Childhood; Trifluperidol | 1968 |
Haloperidol and trifluperidol in psychiatry.
Topics: Antidepressive Agents; Butyrophenones; Fluorine; Haloperidol; Humans; Piperidines; Psychotic Disorders; Trifluperidol | 1968 |
[Treatment of schizophrenic patients with triperidol (trisedil)].
Topics: Antidepressive Agents; Butyrophenones; Catatonia; Female; Fluorine; Humans; Male; Paranoid Disorders; Piperidines; Schizophrenia; Trifluperidol | 1968 |
[Clinical effects of the butyrophenones. Floropipamide (Dipiperon), methylperon (Buronil), trifluperidol (Psicoperidol)].
Topics: Antidepressive Agents; Butyrophenones; Fluorine; Humans; Mental Disorders; Piperidines; Schizophrenia; Tranquilizing Agents; Trifluperidol | 1968 |
Effect of triperidol on carbohydrate and amino acid metabolism in rat brain-cortex slices.
Topics: Amino Acids; Animals; Antidepressive Agents; Aspartic Acid; Butyrophenones; Carbohydrate Metabolism; Cerebral Cortex; Fluorine; Galactose; Glucose; Glutamates; Glycine; In Vitro Techniques; Piperidines; Pyruvates; Rats; Trifluperidol | 1968 |
[Neuroleptics and extrapyramidal effects: correlation between antipsychotic and extrapyramidal properties].
Topics: Antidepressive Agents; Butyrophenones; Chlorpromazine; Extrapyramidal Tracts; Female; Fluorine; Humans; Piperidines; Psychiatric Status Rating Scales; Psychotic Disorders; Tranquilizing Agents; Trifluoperazine; Trifluperidol | 1968 |
[Central and peripheral secondary effects of some butyrophenones].
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Benperidol; Butyrophenones; Central Nervous System; Extrapyramidal Tracts; Female; Fluorine; Haloperidol; Humans; Male; Middle Aged; Movement Disorders; Peripheral Nerves; Piperidines; Sweating; Trifluperidol | 1969 |
Electroencephalographic effects of trifluperidol.
Topics: Adult; Antidepressive Agents; Bipolar Disorder; Butyrophenones; Computers; Dosage Forms; Electroencephalography; Fluorine; Humans; Middle Aged; Piperidines; Schizophrenia; Sleep Stages; Trifluperidol | 1969 |
[Effect of triperidol on glucose and pyruvic acid metabolism in rat cerebral cortex slices].
Topics: Animals; Antidepressive Agents; Autoradiography; Butyrophenones; Carbon Isotopes; Cerebellar Cortex; Chromatography, Paper; Fluorine; Glucose; In Vitro Techniques; Oxygen Consumption; Piperidines; Pyruvates; Rats; Trifluperidol | 1966 |
Effects of haloperidol and trifluperidol on operant behavior in the rat.
Topics: Animals; Antidepressive Agents; Butyrophenones; Caffeine; Conditioning, Operant; Fluorine; Haloperidol; Male; Piperidines; Placebos; Rats; Transfer, Psychology; Trifluperidol | 1967 |
3-Arylpiperidines as potentiators of existing antibacterial agents.
Topics: Anti-Bacterial Agents; Biological Transport, Active; Drug Resistance; Drug Synergism; Escherichia coli; Fluorine; Gram-Negative Bacteria; Inhibitory Concentration 50; Microbial Sensitivity Tests; Permeability; Piperidines; Staphylococcus aureus | 2001 |
Synthesis and structure-activity relationships of N-(1-benzylpiperidin-4-yl)arylacetamide analogues as potent sigma1 receptor ligands.
Topics: Acetamides; Animals; Brain; Fluorine; Guinea Pigs; In Vitro Techniques; Iodine; Ligands; Liver; Models, Molecular; Piperidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Structure-Activity Relationship | 2001 |
3-Fluoropiperidines and N-methyl-3-fluoropiperidinium salts: the persistence of axial fluorine.
Topics: Crystallography, X-Ray; Fluorine; Hydrocarbons, Fluorinated; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Piperidines; Thermodynamics | 2005 |
Methoxy- and fluorine-substituted analogs of O-1302: synthesis and in vitro binding affinity for the CB1 cannabinoid receptor.
Topics: Animals; Blood-Brain Barrier; Cerebellum; Fluorine; Fluorine Radioisotopes; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Membranes; Methylation; Piperidines; Pyrazoles; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2007 |
Synthesis and glycosylation of a series of 6-mono-, di-, and trifluoro S-phenyl 2,3,4-tri-O-benzyl-thiorhamnopyranosides. Effect of the fluorine substituents on glycosylation stereoselectivity.
Topics: Benzylidene Compounds; Carbohydrate Conformation; Carbohydrate Sequence; Fluorine; Furans; Glycosylation; Magnetic Resonance Spectroscopy; Models, Chemical; Molecular Sequence Data; Piperidines; Rhamnose; Stereoisomerism; Sulfonamides; Thioglycosides | 2007 |
Fluorinated piperidine acetic acids as gamma-secretase modulators.
Topics: Acetates; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Diazonium Compounds; Disease Models, Animal; Fluorine; Mice; Mice, Transgenic; Peptide Fragments; Piperidines; Rats; Receptors, Notch | 2010 |
Synthesis of aminomethylated 4-fluoropiperidines and 3-fluoropyrrolidines.
Topics: Chemistry, Pharmaceutical; Fluorine; Molecular Structure; Piperidines; Pyrrolidines; Stereoisomerism | 2010 |
Detection, identification and quantification of a new de-fluorinated impurity in casopitant mesylate drug substance during late phase development: an analytical challenge involving a multidisciplinary approach.
Topics: Chemistry Techniques, Analytical; Chemistry, Pharmaceutical; Chromatography, Liquid; Drug Contamination; Fluorine; Halogenation; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Chemical; Pharmaceutical Preparations; Piperazines; Piperidines; Quality Control; Reproducibility of Results | 2011 |
Discovery of novel (4-piperidinyl)-piperazines as potent and orally active acetyl-CoA carboxylase 1/2 non-selective inhibitors: F-Boc and triF-Boc groups are acid-stable bioisosteres for the Boc group.
Topics: Acetyl-CoA Carboxylase; Administration, Oral; Animals; Fluorine; Formic Acid Esters; Molecular Structure; Piperazine; Piperazines; Piperidines; Rats; Stereoisomerism; Structure-Activity Relationship | 2011 |
Novel purine-based fluoroaryl-1,2,3-triazoles as neuroprotecting agents: synthesis, neuronal cell culture investigations, and CDK5 docking studies.
Topics: Animals; Cell Cycle; Cells, Cultured; Cyclin-Dependent Kinase 5; Flavonoids; Fluorine; Hippocampus; Humans; Hydrogen Bonding; Mice; Models, Molecular; Molecular Structure; Neuroprotective Agents; Piperidines; Protein Kinase Inhibitors; Purines; Roscovitine; Triazoles | 2011 |
Synthesis and pharmacological evaluation of 2-(1-alkylpiperidin-4-yl)-n-[(1r)-1-(4-fluorophenyl)-2-methylpropyl]acetamide Derivatives as Novel Antihypertensive Agents.
Topics: Acetamides; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Fluorine; Male; Mibefradil; Piperidines; Rats; Structure-Activity Relationship | 2012 |
Selective synthesis of functionalized trifluoromethylated pyrrolidines, piperidines, and azepanes starting from 1-tosyl-2-(trifluoromethyl)aziridine.
Topics: Alkylation; Azepines; Aziridines; Crystallography, X-Ray; Fluorine; Molecular Conformation; Piperidines; Pyrrolidines | 2014 |
The effects of fluorine substitution on the chemical properties and inhibitory capacity of Donepezil anti-Alzheimer drug; density functional theory and molecular docking calculations.
Topics: Alzheimer Disease; Donepezil; Electrons; Fluorine; Humans; Hydrogen Bonding; Indans; Models, Molecular; Molecular Docking Simulation; Piperidines; Quantum Theory; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Static Electricity | 2017 |
Aqueous Instability of δ-Fluorobutylpiperidines.
Topics: Drug Stability; Fluorine; Kinetics; Magnetic Resonance Spectroscopy; Piperidines; Spectrometry, Mass, Electrospray Ionization; Water | 2017 |
The position of fluorine in CP-118,954 affects AChE inhibition potency and PET imaging quantification for AChE expression in the rat brain.
Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Fluorine; Fluorine Radioisotopes; Isoxazoles; Microdialysis; Piperidines; Positron-Emission Tomography; Rats, Sprague-Dawley | 2017 |
Self-standing films of octadecylaminated-TEMPO-oxidized cellulose nanofibrils with antifingerprint properties.
Topics: Alkanes; Cellulose, Oxidized; Cyclic N-Oxides; Elastic Modulus; Fluorine; Free Radicals; Hydrophobic and Hydrophilic Interactions; Microscopy, Electron, Scanning; Nanofibers; Oleic Acid; Oxidation-Reduction; Piperidines; Powders; Spectroscopy, Fourier Transform Infrared; Surface Properties; Tensile Strength; Thermogravimetry; Water; X-Ray Diffraction | 2021 |