Page last updated: 2024-08-22

fluorine and piperidines

fluorine has been researched along with piperidines in 60 studies

Research

Studies (60)

TimeframeStudies, this research(%)All Research%
pre-199044 (73.33)18.7374
1990's0 (0.00)18.2507
2000's5 (8.33)29.6817
2010's10 (16.67)24.3611
2020's1 (1.67)2.80

Authors

AuthorsStudies
Hopkała, H; Przyborowski, L1
a'Brook, MF; Tarighati, S1
Monti, JM1
Broomfield, CA; Hackley, BE; Morrisett, JD1
Berliner, LJ1
Nixon, R1
Broomfield, CA; Morrisett, JD1
Leterrier, F; Mariaud, JF; Rieger, F1
Berliner, LJ; Wong, SS1
Berliner, LJ; Quiggle, K; Triplett, C; Wong, SS1
Gary-Bobo, CM; Riguad, JL; Taupin, C1
Draper, MD; Klohs, MW; Levy, L; McClure, DA; Petracek, FJ; Ré, ON1
Williams, CH1
Airoldi, L; Garattini, S; Marcucci, F; Mussini, E1
Tobin, JM1
Hádlík, J; Misurec, J; Náhunek, K; Rodová, A; Vanýsek, J1
Náhunek, K; Svestka, J1
Clark, ML; Colmore, JP; Huber, WK; Kyriakopoulos, AA; Ramsey, HR; Ray, TS2
Dolan, WM; Eger, EI; Miller, RD; Stevens, WC; Way, WL1
Lutz, RE; Ohnmacht, CJ; Patel, AR1
Chin, CG; Micetich, RG; Raap, R1
Assis, LM; Martins, C; Navarro, MP1
Szobor, A1
Hádlik, J; Náhunek, K; Rodová, A; Svestka, J; Vanýsek, J1
Janssen, PA; Niemegeers, CJ; Verbruggen, FJ3
Farcasanu, M; Maniu, M; Uray, Z1
Heykants, JJ; Janssen, PA; Lewi, PJ1
Petri, G; Porszasz-Gibiszer, K; Szenohradszky, J1
Acebal, EM; Spatz, H1
Bordeleau, JM; Gauthier, R; Hillel, J; Tétreault, L1
Burger, A; Pinder, RM1
Le Vann, LJ1
Ezhkov, AA1
Kristjansen, P1
Gatti, GL; Michalek, H; Pocchiari, F1
Bordeleau, JM; Filotto, J; Tetreault, L1
Frosali, L; Gigli, M; Salvini, L1
Fink, M; Itil, T1
Gatti, G; Michalek, H; Pocchiari, F1
Hance, AJ; Monti, JM1
Bohanon, MJ; Boyle, TP; Heckaman, CL; Marotti, KR; Presley-Bodnar, AL; Sweeney, MT; Thorarensen, A; Tomich, PK; Yagi, BH; Zurenko, GE1
Hammond, PS; Huang, Y; Mach, RH; Wu, L1
Hardcastle, K; Lankin, DC; Snyder, JP; Sun, A1
Ishiwata, K; Maeda, M; Mukai, T; Nojiri, Y; Sasada, T; Tobiishi, S; Yamamoto, F1
Crich, D; Vinogradova, O1
Andrade, P; Angagaw, M; Bi, G; Black, RM; Crispino, J; Cruz, JC; Fan, E; Farris, G; Hamblett, C; Hubbs, J; Hughes, BL; Kenific, CM; Middleton, RE; Munoz, B; Nikov, G; Sajonz, P; Shah, S; Shearman, M; Shomer, N; Sloman, D; Stanton, MG; Szewczak, AA; Tanga, F; Tudge, MT1
De Kimpe, N; Deroose, F; Macdonald, G; Piron, K; Thuring, JW; Van Hende, E; Verniest, G1
Bernabè, E; Castoldi, D; Cimarosti, Z; Curcuruto, O; Dams, R; Marchioro, C; Martini, L; Nicoletti, A; Papini, D; Provera, S; Turco, L1
Chonan, T; Hiratate, A; Io, F; Koretsune, H; Ohoka-Sugita, A; Oi, T; Tanaka, H; Wakasugi, D; Yamamoto, D; Yashiro, M1
Abrol, R; Goddard, WA; Kudo, W; Nair, N; Reddy, VP; Smith, MA1
Matsuura, K; Ohta, M; Okada, M; Okazaki, T; Tomura, Y; Tsukamoto, S; Watanuki, S1
D'hooghe, M; De Kimpe, N; Dolfen, J; Kenis, S; Van Hecke, K1
Khosravan, A; Marani, S; Sadeghi Googheri, MS1
Carreira, EM; Müller, K; Vorberg, R1
Altomare, CD; de Candia, M; Denora, N; Jung, JH; Kim, SE; Lee, BC; Moon, BS; Park, DD; Park, HS1
Imae, T; Krathumkhet, N; Ujihara, M1

Trials

5 trial(s) available for fluorine and piperidines

ArticleYear
Management of the schizophrenic patient in a community psychiatric practice.
    Diseases of the nervous system, 1968, Volume: 29, Issue:5

    Topics: Acute Disease; Adolescent; Adult; Aged; Antidepressive Agents; Butyrophenones; Chronic Disease; Clinical Trials as Topic; Community Mental Health Services; Female; Fluorine; Humans; Male; Middle Aged; Piperidines; Schizophrenia; Trifluperidol

1968
[Comparison of triperidol with perphenazine in schizophrenic psychoses. Effect on the photomyoclonic threshold].
    Activitas nervosa superior, 1970, Jan-12, Volume: 12, Issue:1

    Topics: Adolescent; Adult; Antidepressive Agents; Butyrophenones; Clinical Trials as Topic; Depressive Disorder, Major; Female; Fluorine; Humans; Light; Male; Middle Aged; Myoclonus; Perphenazine; Piperidines; Placebos; Reflex; Schizophrenia; Trifluperidol

1970
[Controlled comparative study of methylperidol and perphenazine in schizoprenic psychoses].
    Activitas nervosa superior, 1970, Jan-12, Volume: 12, Issue:1

    Topics: Adolescent; Adult; Aged; Antidepressive Agents; Butyrophenones; Clinical Trials as Topic; Female; Fluorine; Humans; Middle Aged; Perphenazine; Piperidines; Placebos; Schizophrenia

1970
Evaluation of trifluperidol in chronic schizophrenia.
    Psychopharmacologia, 1968, Volume: 12, Issue:3

    Topics: Adult; Age Factors; Antidepressive Agents; Butyrophenones; Chronic Disease; Clinical Trials as Topic; Female; Fluorine; Hospitalization; Humans; Middle Aged; Piperidines; Placebos; Schizophrenia; Trifluperidol

1968
Evaluation of trifluperidol in chronic schizaphrenia.
    Psychopharmacologia, 1968, Volume: 12, Issue:3

    Topics: Adult; Antidepressive Agents; Butyrophenones; Chlorpromazine; Chronic Disease; Clinical Trials as Topic; Female; Fluorine; Humans; Middle Aged; Piperidines; Placebos; Schizophrenia; Trifluperidol

1968

Other Studies

55 other study(ies) available for fluorine and piperidines

ArticleYear
Determination of drugs containing fluorine with ion-selective electrode. Part 2: Butyrophenones and bis(4-fluorophenyl)butylpiperidines.
    Die Pharmazie, 1989, Volume: 44, Issue:1

    Topics: Butyrophenones; Electrodes; Fluorine; Penfluridol; Pimozide; Piperidines; Potentiometry; Spectrophotometry, Ultraviolet

1989
Trifluperidol in Huntington's chorea.
    Lancet (London, England), 1968, Aug-24, Volume: 2, Issue:7565

    Topics: Aged; Antidepressive Agents; Butyrophenones; Fluorine; Humans; Huntington Disease; Middle Aged; Piperidines; Trifluperidol

1968
Effects of haloperidol and trifluperidol on the sleep cycle of the cat.
    Electroencephalography and clinical neurophysiology, 1970, Volume: 28, Issue:5

    Topics: Animals; Antidepressive Agents; Butyrophenones; Cats; Cerebral Cortex; Fluorine; Haloperidol; Muscles; Piperidines; Sleep; Sleep Stages; Sleep, REM; Trifluperidol; Wakefulness

1970
A new spin label specific for the active site of serine enzymes.
    The Journal of biological chemistry, 1969, Oct-25, Volume: 244, Issue:20

    Topics: Acetylcholinesterase; Animals; Binding Sites; Brain Chemistry; Cattle; Cell Membrane; Chemical Phenomena; Chemistry; Chymotrypsin; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Erythrocytes; Fluorine; Free Radicals; Humans; Nerve Endings; Organophosphonates; Piperidines; Rats; Serine

1969
Urea denaturation of active-site spin-labeled -chymotrypsin.
    Biochemistry, 1972, Jul-18, Volume: 11, Issue:15

    Topics: Binding Sites; Chymotrypsin; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Fluorine; Hydrogen-Ion Concentration; Organophosphorus Compounds; Piperidines; Protein Denaturation; Pyrroles; Urea

1972
Volatile amines in mouse brain: a radioassay with picogram sensitivity.
    Analytical biochemistry, 1972, Volume: 48, Issue:2

    Topics: Amines; Animals; Brain Chemistry; Chromatography, Thin Layer; Ethanol; Fluorine; Mathematics; Methods; Mice; Mice, Inbred Strains; Microchemistry; Nitrobenzenes; Perchlorates; Picrates; Piperidines; Pyrrolidines; Radiochemistry; Solvents; Trichloroacetic Acid; Tritium

1972
A comparative study of spin-labeled serine enzymes: acetylcholinesterase, trypsin, -chymotrypsin, elastase, and subtilisin.
    The Journal of biological chemistry, 1972, Nov-25, Volume: 247, Issue:22

    Topics: Acetylcholinesterase; Binding Sites; Chymotrypsin; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Endopeptidases; Fluorine; Hydrogen-Ion Concentration; Indicators and Reagents; Organophosphorus Compounds; Pancreatic Elastase; Piperidines; Protein Binding; Serine; Subtilisins; Trypsin

1972
Comparative study of the action of phenothiazine and para-fluorobutyrophenone derivatives on rat brain membranes using the spin label technique.
    The Journal of pharmacology and experimental therapeutics, 1973, Volume: 186, Issue:3

    Topics: Animals; Brain; Butyrophenones; Cerebral Cortex; Cyclic N-Oxides; Dimethyl Sulfoxide; Electron Spin Resonance Spectroscopy; Erythrocytes; Fluorine; Male; Maleimides; Membranes; Myelin Sheath; Phenothiazines; Piperidines; Rats; Synaptosomes

1973
Spin-labeled sulfonyl fluorides as active site probes of protease structure. I. Comparison of the active site environments in alpha-chymotrypsin and trypsin.
    The Journal of biological chemistry, 1974, Mar-25, Volume: 249, Issue:6

    Topics: Amidines; Benzene Derivatives; Benzenesulfonates; Binding Sites; Chemical Phenomena; Chemistry; Chymotrypsin; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Fluorine; Hydrogen-Ion Concentration; Indoles; Isomerism; Models, Structural; Piperidines; Protein Conformation; Pyrroles; Pyrrolidines; Structure-Activity Relationship; Tosyl Compounds; Trypsin; Trypsin Inhibitors

1974
Spin-labeled sulfonyl fluorides as active site probes of protease structure. II. Spin label syntheses and enzyme inhibition.
    The Journal of biological chemistry, 1974, Mar-25, Volume: 249, Issue:6

    Topics: Benzenesulfonates; Binding Sites; Chymotrypsin; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Evaluation Studies as Topic; Fluorine; Hydrolysis; Methods; Piperidines; Structure-Activity Relationship; Time Factors; Tosyl Compounds; Trypsin; Trypsin Inhibitors

1974
Effect of chemical modifiers of passive permeability on the conformation of spin-labeled erythrocyte membranes.
    Biochimica et biophysica acta, 1974, Dec-10, Volume: 373, Issue:2

    Topics: Benzenesulfonates; Cell Membrane Permeability; Chloromercuribenzoates; Electron Spin Resonance Spectroscopy; Erythrocytes; Ethylmaleimide; Fluorine; Humans; Hydrogen-Ion Concentration; Iodoacetates; Maleimides; Mercury; Molecular Conformation; Nitrobenzenes; Organometallic Compounds; Osmolar Concentration; Piperidines; Protein Binding; Spin Labels; Stearic Acids; Sulfhydryl Compounds; Temperature; Time Factors; Tropanes

1974
Fluorophenyl-4-(p-fluorophenyl)-4-hydroxy-1-methyl-3-piperidyl ketone (flazalone): a novel non-steroidal anti-inflammatory agent.
    Arzneimittel-Forschung, 1972, Volume: 22, Issue:10

    Topics: Administration, Oral; Analgesics; Anaphylaxis; Animals; Anti-Inflammatory Agents; Arthritis; Edema; Fever; Fluorine; Graft Rejection; Humans; Ketones; Mice; Piperidines; Rabbits; Rats

1972
Monoamine oxidase. I. Specificity of some substrates and inhibitors.
    Biochemical pharmacology, 1974, Feb-01, Volume: 23, Issue:3

    Topics: Amines; Amphetamine; Animals; Benzyl Compounds; Brain; Cyclohexylamines; Fluorine; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Mitochondria; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nerve Tissue Proteins; Oxidation-Reduction; Oximes; Phenethylamines; Phenylbutyrates; Phenylpropanolamine; Piperidines; Potentiometry; Swine; Tyramine

1974
Distribution of penfluridol in rats and mice.
    European journal of pharmacology, 1974, Volume: 25, Issue:3

    Topics: Adipose Tissue; Animals; Brain; Cerebellum; Chromatography, Gas; Corpus Striatum; Dextroamphetamine; Diencephalon; Fluorine; Humans; Hydrocarbons, Halogenated; Male; Mesencephalon; Mice; Piperidines; Rats; Stereotyped Behavior; Time Factors; Toluene; Tranquilizing Agents

1974
Comparative neuromuscular effects of pancuronium, gallamine, and succinylcholine during forane and halothane anesthesia in man.
    Anesthesiology, 1971, Volume: 35, Issue:5

    Topics: Adult; Aged; Androstanes; Anesthesia, Inhalation; Chlorine; Drug Synergism; Electric Stimulation; Ethers; Fluorine; Gallamine Triethiodide; Halothane; Humans; Hydrocarbons, Halogenated; Injections, Intravenous; Middle Aged; Muscles; Piperidines; Succinylcholine; Ulnar Nerve

1971
Antimalarials. 7. Bis(trifluoromethyl)- -(2-piperidyl)-4-quinolinemethanols.
    Journal of medicinal chemistry, 1971, Volume: 14, Issue:10

    Topics: Animals; Antimalarials; Fluorine; Malaria; Methanol; Mice; Piperidines; Quinolines; Spectrum Analysis; Time Factors; Ultraviolet Rays

1971
Studies in isoxazole chemistry. 5. N-alkylation and N-acylation of 5-amino-3-(5-nitro-2-furyl)isoxazoles.
    Journal of medicinal chemistry, 1971, Volume: 14, Issue:9

    Topics: Acetamides; Allyl Compounds; Amides; Amines; Animals; Bacteria; Carbamates; Carboxylic Acids; Chlorine; Fluorine; Furans; Morpholines; Nitriles; Nitro Compounds; Oxazoles; Piperidines; Structure-Activity Relationship; Trichomonas

1971
[Clinical results with trifluoperidol in schizophrenic patients].
    Revista da Associacao Medica Brasileira, 1966, Volume: 12, Issue:12

    Topics: Adolescent; Adult; Antidepressive Agents; Butyrophenones; Fluorine; Humans; Male; Piperidines; Schizophrenia; Trifluperidol

1966
Results of trifluperidol therapy.
    Therapia Hungarica (English edition), 1969, Volume: 17, Issue:3

    Topics: Adolescent; Adult; Aged; Antidepressive Agents; Butyrophenones; Fluorine; Haloperidol; Humans; Mental Disorders; Middle Aged; Piperidines; Trifluperidol

1969
[Comparison of the therapeutic effect of triperidol with perphenazine in schizophrenia].
    Ceskoslovenska psychiatrie, 1969, Volume: 65, Issue:5

    Topics: Adolescent; Adult; Antidepressive Agents; Butyrophenones; Female; Fluorine; Humans; Male; Middle Aged; Perphenazine; Piperidines; Schizophrenia; Trifluperidol

1969
The influence of various neuroleptic drugs on shock avoidance responding in rats. I. Nondiscriminated Sidman avoidance procedure.
    Psychopharmacologia, 1969, Volume: 16, Issue:3

    Topics: Animals; Antidepressive Agents; Avoidance Learning; Benperidol; Benzimidazoles; Butyrophenones; Chlorpromazine; Depression, Chemical; Electroshock; Escape Reaction; Female; Fluorine; Fluphenazine; Haloperidol; Isonipecotic Acids; Perphenazine; Piperidines; Promazine; Rats; Spiro Compounds; Thioridazine; Tranquilizing Agents; Trifluoperazine

1969
The influence of various neuroleptic drugs on shock avoidance responding in rats. II. Nondiscriminated Sidman avoidance procedure with alternate reinforcement and extinction periods and analysis of the interresponse times (IRT's).
    Psychopharmacologia, 1969, Volume: 16, Issue:3

    Topics: Animals; Antidepressive Agents; Avoidance Learning; Benperidol; Blepharoptosis; Butyrophenones; Catalepsy; Chlorpromazine; Depression, Chemical; Electroshock; Escape Reaction; Extinction, Psychological; Female; Fluorine; Haloperidol; Humans; Piperidines; Rats; Reinforcement, Psychology; Time Factors; Tranquilizing Agents; Trifluperidol

1969
[Radioprotective properties of butyrophenone derivatives].
    Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression, 1970, Volume: 11, Issue:4

    Topics: Animals; Antidepressive Agents; Benperidol; Butyrophenones; Fluorine; Haloperidol; Iron Isotopes; Male; Mice; Piperidines; Radiation Injuries, Experimental; Radiation Protection; Radiation-Protective Agents; Trifluperidol

1970
The influence of various neuroleptic drugs on noise escape response in rats.
    Psychopharmacologia, 1970, Volume: 18, Issue:3

    Topics: Animals; Antidepressive Agents; Avoidance Learning; Benperidol; Blepharoptosis; Butyrophenones; Catalepsy; Chlorpromazine; Escape Reaction; Female; Fluorine; Fluphenazine; Haloperidol; Humans; Noise; Perphenazine; Piperidines; Rats; Spiro Compounds; Thioridazine; Tranquilizing Agents; Trifluoperazine; Triflupromazine

1970
On the distribution and metabolism of neuroleptic drugs. 3. Pharmacokinetics of trifluperidol.
    Arzneimittel-Forschung, 1970, Volume: 20, Issue:11

    Topics: Animals; Antidepressive Agents; Brain; Butyrophenones; Feces; Fluorine; Liver; Piperidines; Rats; Trifluperidol; Tritium

1970
Sympatholytic treatment of "paralytic" ileus.
    Surgery, 1971, Volume: 70, Issue:3

    Topics: Antidepressive Agents; Butyrophenones; Carbamates; Catecholamines; Chlorpromazine; Diagnosis, Differential; Drug Synergism; Fluorine; Gastrointestinal Diseases; Gastrointestinal Motility; Humans; Ileum; Intestinal Diseases; Neostigmine; Paralysis; Piperidines; Pyridinium Compounds; Trifluperidol

1971
Effect of trifluperidol (R 2498) on the urinary elimination of bufotenin in schizophrenia.
    International journal of neuropsychiatry, 1967, Volume: 3, Issue:6

    Topics: Adolescent; Adult; Antidepressive Agents; Butyrophenones; Convulsive Therapy; Electroconvulsive Therapy; Fluorine; Hallucinogens; Humans; Male; Piperidines; Schizophrenia; Trifluperidol

1967
[Comparative study of trifluperidol and trifluoperazine in the treatment of acute schizophrenia].
    L'union medicale du Canada, 1967, Volume: 96, Issue:8

    Topics: Antidepressive Agents; Butyrophenones; Chlorpromazine; Female; Fluorine; Humans; Male; Middle Aged; Piperidines; Schizophrenia; Trifluoperazine

1967
Antimalarials. II. Alpha-(2-piperidyl)-and alpha-(2-pyridyl)-2-trifluoromethyl-4-quinolinemethanols.
    Journal of medicinal chemistry, 1968, Volume: 11, Issue:2

    Topics: Animals; Antimalarials; Fluorine; Mice; Photosensitivity Disorders; Piperidines; Plasmodium; Pyridines; Quinolines

1968
A new butyrophenone: trifluperidol. A psychiatric evaluation in a pediatric setting.
    Canadian Psychiatric Association journal, 1968, Volume: 13, Issue:3

    Topics: Adolescent; Antidepressive Agents; Aspartate Aminotransferases; Attention; Brain Damage, Chronic; Butyrophenones; Child; Child Behavior Disorders; Child, Preschool; Fluorine; Humans; Piperidines; Psychotic Disorders; Schizophrenia, Childhood; Trifluperidol

1968
Haloperidol and trifluperidol in psychiatry.
    Drug and therapeutics bulletin, 1968, Jul-19, Volume: 6, Issue:15

    Topics: Antidepressive Agents; Butyrophenones; Fluorine; Haloperidol; Humans; Piperidines; Psychotic Disorders; Trifluperidol

1968
[Treatment of schizophrenic patients with triperidol (trisedil)].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1968, Volume: 68, Issue:9

    Topics: Antidepressive Agents; Butyrophenones; Catatonia; Female; Fluorine; Humans; Male; Paranoid Disorders; Piperidines; Schizophrenia; Trifluperidol

1968
[Clinical effects of the butyrophenones. Floropipamide (Dipiperon), methylperon (Buronil), trifluperidol (Psicoperidol)].
    Nordisk psykiatrisk tidsskrift. Nordic journal of psychiatry, 1968, Volume: 22, Issue:3

    Topics: Antidepressive Agents; Butyrophenones; Fluorine; Humans; Mental Disorders; Piperidines; Schizophrenia; Tranquilizing Agents; Trifluperidol

1968
Effect of triperidol on carbohydrate and amino acid metabolism in rat brain-cortex slices.
    The Biochemical journal, 1968, Volume: 110, Issue:2

    Topics: Amino Acids; Animals; Antidepressive Agents; Aspartic Acid; Butyrophenones; Carbohydrate Metabolism; Cerebral Cortex; Fluorine; Galactose; Glucose; Glutamates; Glycine; In Vitro Techniques; Piperidines; Pyruvates; Rats; Trifluperidol

1968
[Neuroleptics and extrapyramidal effects: correlation between antipsychotic and extrapyramidal properties].
    Canadian Psychiatric Association journal, 1968, Volume: 13, Issue:6

    Topics: Antidepressive Agents; Butyrophenones; Chlorpromazine; Extrapyramidal Tracts; Female; Fluorine; Humans; Piperidines; Psychiatric Status Rating Scales; Psychotic Disorders; Tranquilizing Agents; Trifluoperazine; Trifluperidol

1968
[Central and peripheral secondary effects of some butyrophenones].
    Minerva anestesiologica, 1969, Apr-04, Volume: 35, Issue:4

    Topics: Adolescent; Adult; Aged; Antidepressive Agents; Benperidol; Butyrophenones; Central Nervous System; Extrapyramidal Tracts; Female; Fluorine; Haloperidol; Humans; Male; Middle Aged; Movement Disorders; Peripheral Nerves; Piperidines; Sweating; Trifluperidol

1969
Electroencephalographic effects of trifluperidol.
    Diseases of the nervous system, 1969, Volume: 30, Issue:8

    Topics: Adult; Antidepressive Agents; Bipolar Disorder; Butyrophenones; Computers; Dosage Forms; Electroencephalography; Fluorine; Humans; Middle Aged; Piperidines; Schizophrenia; Sleep Stages; Trifluperidol

1969
[Effect of triperidol on glucose and pyruvic acid metabolism in rat cerebral cortex slices].
    Annali dell'Istituto superiore di sanita, 1966, Volume: 2, Issue:2

    Topics: Animals; Antidepressive Agents; Autoradiography; Butyrophenones; Carbon Isotopes; Cerebellar Cortex; Chromatography, Paper; Fluorine; Glucose; In Vitro Techniques; Oxygen Consumption; Piperidines; Pyruvates; Rats; Trifluperidol

1966
Effects of haloperidol and trifluperidol on operant behavior in the rat.
    Psychopharmacologia, 1967, Volume: 12, Issue:1

    Topics: Animals; Antidepressive Agents; Butyrophenones; Caffeine; Conditioning, Operant; Fluorine; Haloperidol; Male; Piperidines; Placebos; Rats; Transfer, Psychology; Trifluperidol

1967
3-Arylpiperidines as potentiators of existing antibacterial agents.
    Bioorganic & medicinal chemistry letters, 2001, Jul-23, Volume: 11, Issue:14

    Topics: Anti-Bacterial Agents; Biological Transport, Active; Drug Resistance; Drug Synergism; Escherichia coli; Fluorine; Gram-Negative Bacteria; Inhibitory Concentration 50; Microbial Sensitivity Tests; Permeability; Piperidines; Staphylococcus aureus

2001
Synthesis and structure-activity relationships of N-(1-benzylpiperidin-4-yl)arylacetamide analogues as potent sigma1 receptor ligands.
    Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25

    Topics: Acetamides; Animals; Brain; Fluorine; Guinea Pigs; In Vitro Techniques; Iodine; Ligands; Liver; Models, Molecular; Piperidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Structure-Activity Relationship

2001
3-Fluoropiperidines and N-methyl-3-fluoropiperidinium salts: the persistence of axial fluorine.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2005, Feb-18, Volume: 11, Issue:5

    Topics: Crystallography, X-Ray; Fluorine; Hydrocarbons, Fluorinated; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Piperidines; Thermodynamics

2005
Methoxy- and fluorine-substituted analogs of O-1302: synthesis and in vitro binding affinity for the CB1 cannabinoid receptor.
    Chemical & pharmaceutical bulletin, 2007, Volume: 55, Issue:8

    Topics: Animals; Blood-Brain Barrier; Cerebellum; Fluorine; Fluorine Radioisotopes; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Membranes; Methylation; Piperidines; Pyrazoles; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant

2007
Synthesis and glycosylation of a series of 6-mono-, di-, and trifluoro S-phenyl 2,3,4-tri-O-benzyl-thiorhamnopyranosides. Effect of the fluorine substituents on glycosylation stereoselectivity.
    Journal of the American Chemical Society, 2007, Sep-26, Volume: 129, Issue:38

    Topics: Benzylidene Compounds; Carbohydrate Conformation; Carbohydrate Sequence; Fluorine; Furans; Glycosylation; Magnetic Resonance Spectroscopy; Models, Chemical; Molecular Sequence Data; Piperidines; Rhamnose; Stereoisomerism; Sulfonamides; Thioglycosides

2007
Fluorinated piperidine acetic acids as gamma-secretase modulators.
    Bioorganic & medicinal chemistry letters, 2010, Jan-15, Volume: 20, Issue:2

    Topics: Acetates; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Diazonium Compounds; Disease Models, Animal; Fluorine; Mice; Mice, Transgenic; Peptide Fragments; Piperidines; Rats; Receptors, Notch

2010
Synthesis of aminomethylated 4-fluoropiperidines and 3-fluoropyrrolidines.
    Organic & biomolecular chemistry, 2010, Jun-07, Volume: 8, Issue:11

    Topics: Chemistry, Pharmaceutical; Fluorine; Molecular Structure; Piperidines; Pyrrolidines; Stereoisomerism

2010
Detection, identification and quantification of a new de-fluorinated impurity in casopitant mesylate drug substance during late phase development: an analytical challenge involving a multidisciplinary approach.
    Journal of pharmaceutical and biomedical analysis, 2011, Jan-05, Volume: 54, Issue:1

    Topics: Chemistry Techniques, Analytical; Chemistry, Pharmaceutical; Chromatography, Liquid; Drug Contamination; Fluorine; Halogenation; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Chemical; Pharmaceutical Preparations; Piperazines; Piperidines; Quality Control; Reproducibility of Results

2011
Discovery of novel (4-piperidinyl)-piperazines as potent and orally active acetyl-CoA carboxylase 1/2 non-selective inhibitors: F-Boc and triF-Boc groups are acid-stable bioisosteres for the Boc group.
    Bioorganic & medicinal chemistry, 2011, Mar-01, Volume: 19, Issue:5

    Topics: Acetyl-CoA Carboxylase; Administration, Oral; Animals; Fluorine; Formic Acid Esters; Molecular Structure; Piperazine; Piperazines; Piperidines; Rats; Stereoisomerism; Structure-Activity Relationship

2011
Novel purine-based fluoroaryl-1,2,3-triazoles as neuroprotecting agents: synthesis, neuronal cell culture investigations, and CDK5 docking studies.
    Bioorganic & medicinal chemistry letters, 2011, Jul-01, Volume: 21, Issue:13

    Topics: Animals; Cell Cycle; Cells, Cultured; Cyclin-Dependent Kinase 5; Flavonoids; Fluorine; Hippocampus; Humans; Hydrogen Bonding; Mice; Models, Molecular; Molecular Structure; Neuroprotective Agents; Piperidines; Protein Kinase Inhibitors; Purines; Roscovitine; Triazoles

2011
Synthesis and pharmacological evaluation of 2-(1-alkylpiperidin-4-yl)-n-[(1r)-1-(4-fluorophenyl)-2-methylpropyl]acetamide Derivatives as Novel Antihypertensive Agents.
    Chemical & pharmaceutical bulletin, 2012, Volume: 60, Issue:2

    Topics: Acetamides; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Fluorine; Male; Mibefradil; Piperidines; Rats; Structure-Activity Relationship

2012
Selective synthesis of functionalized trifluoromethylated pyrrolidines, piperidines, and azepanes starting from 1-tosyl-2-(trifluoromethyl)aziridine.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2014, Aug-18, Volume: 20, Issue:34

    Topics: Alkylation; Azepines; Aziridines; Crystallography, X-Ray; Fluorine; Molecular Conformation; Piperidines; Pyrrolidines

2014
The effects of fluorine substitution on the chemical properties and inhibitory capacity of Donepezil anti-Alzheimer drug; density functional theory and molecular docking calculations.
    Journal of molecular graphics & modelling, 2017, Volume: 71

    Topics: Alzheimer Disease; Donepezil; Electrons; Fluorine; Humans; Hydrogen Bonding; Indans; Models, Molecular; Molecular Docking Simulation; Piperidines; Quantum Theory; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Static Electricity

2017
Aqueous Instability of δ-Fluorobutylpiperidines.
    ChemMedChem, 2017, 03-17, Volume: 12, Issue:6

    Topics: Drug Stability; Fluorine; Kinetics; Magnetic Resonance Spectroscopy; Piperidines; Spectrometry, Mass, Electrospray Ionization; Water

2017
The position of fluorine in CP-118,954 affects AChE inhibition potency and PET imaging quantification for AChE expression in the rat brain.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2017, Nov-15, Volume: 109

    Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Fluorine; Fluorine Radioisotopes; Isoxazoles; Microdialysis; Piperidines; Positron-Emission Tomography; Rats, Sprague-Dawley

2017
Self-standing films of octadecylaminated-TEMPO-oxidized cellulose nanofibrils with antifingerprint properties.
    Carbohydrate polymers, 2021, Mar-15, Volume: 256

    Topics: Alkanes; Cellulose, Oxidized; Cyclic N-Oxides; Elastic Modulus; Fluorine; Free Radicals; Hydrophobic and Hydrophilic Interactions; Microscopy, Electron, Scanning; Nanofibers; Oleic Acid; Oxidation-Reduction; Piperidines; Powders; Spectroscopy, Fourier Transform Infrared; Surface Properties; Tensile Strength; Thermogravimetry; Water; X-Ray Diffraction

2021