fluorine has been researched along with methotrexate in 13 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (38.46) | 18.7374 |
| 1990's | 5 (38.46) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| el-Tahtawy, A; Wolf, W | 1 |
| McHenry, CS; Santi, DV; Sommer, H | 1 |
| Danenberg, PV; Heidelberger, C; Langenbach, RJ | 1 |
| McHenry, CS; Perriard, ER; Santi, DV | 1 |
| Rizki, RM; Rizki, TM | 1 |
| Bessell, EM; Courtenay, VD; Foster, AB; Jones, M; Westwood, JH | 1 |
| Heerschap, A; Hofs, HP; Kamm, VJ; Rietjens, IM; Rosenbusch, G; Vervoort, J; Wagener, DJ | 1 |
| Fetzer, OS; Freisheim, JH; Hynes, JB; Shane, B | 1 |
| Gerig, JT; Lau, EY | 1 |
| Hori, Y; Kawada, K; Kawata, K; Kokuryo, Y; Kugimiya, A; Kuwabara, K; Matsumoto, M; Nakatani, T; Ohtani, M; Suzuki, R; Tamura, Y | 1 |
| Berman, E; Chatterjee-Parti, S; Katzir, I; Shani, J; Wolf, W | 1 |
| Bornmann, WG; Gade, TP; Gorlick, R; Koutcher, JA; Spees, WM; Tong, WP; Yang, G | 1 |
| Danga, A; Hemmaway, CJ; Igbokwe, U; Radunovic, A | 1 |
13 other study(ies) available for fluorine and methotrexate
| Article | Year |
|---|---|
In vivo measurements of intratumoral metabolism, modulation, and pharmacokinetics of 5-fluorouracil, using 19F nuclear magnetic resonance spectroscopy.
Topics: Animals; Carcinoma 256, Walker; Fluorine; Fluorouracil; Kinetics; Least-Squares Analysis; Magnetic Resonance Spectroscopy; Male; Methotrexate; Models, Biological; Rats; Rats, Inbred Strains | 1991 |
Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate.
Topics: Chlorine; Chromatography; Chromatography, Ion Exchange; Deoxyribonucleotides; Drug Resistance, Microbial; Drug Stability; Enzyme Activation; Fluorine; Folic Acid; Guanidines; Kinetics; Lacticaseibacillus casei; Methotrexate; Methyltransferases; Peptide Fragments; Pronase; Protein Binding; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Tetrahydrofolates; Thermodynamics; Thymidylate Synthase; Tritium; Uracil Nucleotides | 1974 |
Structures of reversible and irreversible complexes of thymidylate synthetase and fluorinated pyrimidine nucleotides.
Topics: Amides; Binding Sites; Binding, Competitive; Carbon Radioisotopes; Cysteine; Deoxyribonucleotides; Drug Resistance, Microbial; Fluorine; Iodoacetates; Kinetics; Lacticaseibacillus casei; Methotrexate; Methyltransferases; Models, Chemical; Peptide Fragments; Protein Binding; Protein Denaturation; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Tetrahydrofolates; Thymidylate Synthase; Tritium; Trypsin; Uracil Nucleotides | 1974 |
A filter assay for thymidylate synthetase using 5-fluoro-2'-deoxyuridylate as an active site titrant.
Topics: Animals; Binding Sites; Carcinoma, Hepatocellular; Cell-Free System; Cytoplasm; Deoxyribonucleotides; Drug Resistance, Microbial; Evaluation Studies as Topic; Filtration; Fluorine; Kinetics; Lacticaseibacillus casei; Liver Neoplasms; Methods; Methotrexate; Methyltransferases; Neoplasms, Experimental; Rats; Spectrophotometry; Tetrahydrofolates; Thymidylate Synthase; Tritium; Uracil Nucleotides | 1974 |
The role of thymidylate synthetase inhibitors in bromodeoxyuridine-induced neoplasia in Drosophila.
Topics: Animals; Bromodeoxyuridine; Centrifugation, Density Gradient; DNA; Drosophila; Fluorine; Fluorouracil; Idoxuridine; Larva; Methotrexate; Methyltransferases; Neoplasms, Experimental; Thymidine; Thymidylate Synthase; Tritium | 1973 |
Some in vivo and in vitro antitumour effects of the deoxyfluoro-D-glucopyranoses.
Topics: Animals; Antineoplastic Agents; Cell Count; Cells, Cultured; Deoxy Sugars; Fluorine; Galactose; Glucose; Lymphoma; Methotrexate; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Structure-Activity Relationship; Time Factors | 1973 |
Effect of modulators on 5-fluorouracil metabolite patterns in murine colon carcinoma determined by in vitro 19F nuclear magnetic resonance spectroscopy.
Topics: Animals; Aspartic Acid; Colonic Neoplasms; Female; Fluorine; Fluorouracil; Interferon-alpha; Leucovorin; Magnetic Resonance Spectroscopy; Methotrexate; Mice; Mice, Inbred C57BL; Phosphonoacetic Acid; Rats; Tumor Cells, Cultured | 1994 |
Synthesis and preliminary biological evaluation of analogues of 5,8-dideazaisofolic acid and its 2-desamino-2-methyl derivative containing fluorine at position five.
Topics: Animals; Cell Survival; Fluorine; Folic Acid Antagonists; Leukemia L1210; Liver; Methotrexate; Mice; Peptide Synthases; Quinazolines; Structure-Activity Relationship; Swine; Tumor Cells, Cultured | 1993 |
Effects of fluorine substitution on the structure and dynamics of complexes of dihydrofolate reductase (Escherichia coli).
Topics: Amides; Amino Acid Sequence; Binding Sites; Computer Simulation; Escherichia coli; Fluorine; Folic Acid; Ligands; Magnetic Resonance Spectroscopy; Methotrexate; Models, Chemical; Models, Structural; Protein Binding; Protein Conformation; Protein Structure, Secondary; Software; Tetrahydrofolate Dehydrogenase; Time Factors; Tryptophan | 1997 |
Synthesis and evaluation of novel fluorinated methotrexate derivatives for application to rheumatoid arthritis treatment.
Topics: Animals; Antibody Formation; Arthritis, Experimental; Arthritis, Rheumatoid; B-Lymphocytes; Female; Fluorine; Folic Acid Antagonists; Methotrexate; Mice; Models, Chemical; Rats; Rats, Inbred Lew; Stereoisomerism; T-Lymphocytes | 1997 |
Enhancement of 5-fluorouracil anabolism by methotrexate and trimetrexate in two rat solid tumor models, Walker 256 carcinosarcoma and Novikoff hepatoma, as evaluated by 19F-magnetic resonance spectroscopy.
Topics: Animals; Carcinoma 256, Walker; Drug Administration Schedule; Fluorine; Fluorouracil; Kinetics; Liver Neoplasms, Experimental; Magnetic Resonance Spectroscopy; Male; Methotrexate; Rats; Rats, Sprague-Dawley; Trimetrexate | 2000 |
An 19F magnetic resonance-based in vivo assay of solid tumor methotrexate resistance: proof of principle.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Fluorine; Humans; Magnetic Resonance Spectroscopy; Male; Methotrexate; Mice; Mice, Nude; Sarcoma; Treatment Outcome; Xenograft Model Antitumor Assays | 2005 |
FDG-PET guided diagnosis of vaginal intravascular diffuse large B-cell lymphoma.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Capillaries; Cyclophosphamide; Fatal Outcome; Female; Fluorine; Fluorodeoxyglucose F18; Humans; Immunoglobulin M; Lymphatic Metastasis; Lymphoma, Large B-Cell, Diffuse; Magnetic Resonance Imaging; Methotrexate; Paraproteins; Positron-Emission Tomography; Prednisolone; Radiopharmaceuticals; Vagina; Vascular Neoplasms; Vincristine | 2012 |