Compounds > fluorine
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fluorine and fluorouracil

fluorine has been researched along with fluorouracil in 101 studies

Research

Studies (101)

TimeframeStudies, this research(%)All Research%
pre-199048 (47.52)18.7374
1990's29 (28.71)18.2507
2000's18 (17.82)29.6817
2010's6 (5.94)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Atkins, HL; Bradley-Moore, PR; Casella, V; Fowler, JS; Greenberg, D; Ido, T; Lambrecht, RM; MacGregor, R; Mantescu, C; Meaney, K; Neirinckx, R; Schlesinger, T; Shani, J; Som, P; Wodinsky, I; Wolf, AP; Wolf, W1
Eifinger, FF; Köhler, F1
Vine, EN; Vine, WH; Wolf, W; Young, D1
Chu, WC; Derrick, WB; Feiz, V; Horowitz, J1
Chu, WC; Horowitz, J; Kintanar, A1
Harada, M; Koga, K; Miura, I; Nishitani, H; Umeno, Y1
Chu, WC; Horowitz, J2
Harada, M; Koga, K; Miura, I; Nishitani, H; Shirahama, T1
Bachert, P; Port, RE; Semmler, W1
Baldwin, NJ; Ng, TC; Sijens, PE1
Croisy, A; Guerquin-Kern, JL; Leteurtre, F; Lhoste, JM1
el-Tahtawy, A; Wolf, W1
Bachert-Baumann, P; Ermark, F; Gückel, F; Lorenz, WJ; Schlag, P; Semmler, W; van Kaick, G1
Hirose, S; Kito, M; Takeshima, S; Urakami, K; Yoshida, S1
Albright, MJ; Atkinson, D; Blayney, D; King, M; Ong, RL; Presant, CA; Ring, R; Servis, KL; Wiseman, C; Wolf, W1
Albright, MJ; Atkinson, D; Barker, PB; el-Tahtawy, A; King, M; Ong, R; Presant, CA; Ring, R; Servis, KL; Wolf, W1
Armand, JP; De Forni, M; Malet-Martino, MC; Martino, R1
Aymami, J; Coll, M; Frederick, CA; Rich, A; Saal, D; Wang, AH1
Faure, F; Hollande, E; Malet-Martino, MC; Martino, R; Palevody, C; Vialaneix, JP1
Eritja, R; Fazakerly, GV; Goodman, MF; Kaplan, B; Sowers, LC1
Gollnick, P; Hardin, CC; Horowitz, J1
Cohn, M; Gollnick, P; Hardin, CC; Horowitz, J; Kallenbach, NR1
Armand, JP; Bernadou, J; Lopez, A; Malet-Martino, MC; Martino, R1
Cohen, JL; Manaka, RC; Shani, J; Wolf, W; Young, D1
Bean, B; Tomasz, A1
Cheng, CC1
Granick, S; Kappas, A1
Seeber, S; Warnecke, P; Weitzel, G1
Bruns, R; Hall, TC; Kessel, D1
Williams, JP1
Heidelberger, C1
Pitot, HC; Wilkinson, DS1
Chanock, RM; Gharpure, MA; Hodes, DS; Wright, PF1
Chanock, RM; Hetrick, FM; Kalica, AR; Wright, PF1
Kaiser, II; Kwong, L1
Gerhart, JC; O'Donovan, GA1
Polak, A; Scholer, HJ1
Finn, RD; Fowler, JS; Lambrecht, RM; Wolf, AP1
Rizki, RM; Rizki, TM1
Barton, DH; Hesse, RH; Pechet, MM; To, HT1
Lukezic, FL; Miehle, BR1
Baranosky, J; Lebowitz, E; Richards, P1
Ambre, JJ; Fischer, LJ1
Kolár, V; Mechl, Z1
Jund, R; Lacroute, F1
Giege, R; Weil, JH1
Koenig, H1
Chae, CB; Irvin, JL; Piantadosi, C1
Bunker, JE; Keller, F; Tyrrill, AR1
Coffey, JJ1
Burchenal, JH; Duschinsky, R; Fox, JJ; Gabriel, T; Grunberg, E; Hoffer, M; Nussbaum, A; Tautz, W1
Creasey, WA; Sartorelli, AC1
Gustavsson, B; Hafström, L1
Abe, Y; Endo, S; Fukuda, H; Ido, T; Ishiwata, K; Kubota, K; Matsuzawa, T; Sato, T; Takahashi, T; Yamada, K; Yoshioka, S1
Ido, T; Ishiwata, K; Kawashima, K; Murakami, M; Takahashi, T1
Abe, Y; Ido, T; Ishiwata, K; Iwata, R; Kameyama, M; Matsuzawa, T; Monma, M; Takahashi, T; Tsurumi, Y1
Ghanbarpour, A; Shani, J; Siemsen, JK; Vine, E; Wolf, W; Young, D1
Diksic, M; Farrokhzad, S; Feindel, W; Yamamoto, YL1
Griffiths, JR; Iles, RA; Morris, PG; Sheldon, PW; Stevens, AN1
Bateman, JR; Chlebowski, RT; Schlesinger, T; Shani, J; Siemsen, JK; Wolf, W; Young, D1
Bogden, AE; Gatley, SJ; Lieberman, LM; Nickles, RJ; Wessels, BW; Wiley, AL; Wolberg, WH; Young, D1
Kealey, JT; Santi, DV1
Findlay, MP; Leach, MO1
Chen, TB; Huzak, M; Macura, S; Vuk-Pavlović, S1
Kanazawa, Y; Kurogi, S; Masuda, K; Noda, Y; Shinohara, S1
Heerschap, A; Hofs, HP; Kamm, VJ; Rietjens, IM; Rosenbusch, G; Vervoort, J; Wagener, DJ1
Ascoli, G; Bertucci, C; Di Bari, L; Salvadori, P; Uccello-Barretta, G1
Gonen, O; Li, CW1
Heerschap, A; Kamm, YJ; Rietjens, IM; Rosenbusch, G; Vervoort, J; Wagener, DJ1
Brown, TR; Gonen, O; Li, CW; Murphy-Boesch, J; Negendank, WG; Padavic-Shaller, K1
Collins, DJ; Cunningham, D; Findlay, MP; Iveson, A; Leach, MO; Raynaud, F1
Hirai, N; Lee, YS; Okuno, K; Tarabar, D; Ueno, H; Yasutomi, M1
Aboagye, EO; Artemov, D; Bhujwalla, ZM; Senter, PD1
Bellemann, ME; Brix, G; Gerlach, L; Haberkorn, U1
Bachert, P; Becker, M; Dietz, A; Knopp, MV; Rudat, V; Schlemmer, HP; van Kaick, G; Vanselow, B; Wannenmacher, M; Weidauer, H; Wollensack, P; Zuna, I1
Girard, F; Ikehira, H; Ito, H; Kamei, H; Kanazawa, Y; Miyazaki, M; Nakajima, N; Obata, T; Sasaki, Y; Takano, H; Tanada, S; Yoshitomi, H1
Presant, CA; Waluch, V; Wolf, W1
Berman, E; Chatterjee-Parti, S; Katzir, I; Shani, J; Wolf, W1
Collins, DJ; Leach, MO; Li, BS; Payne, GS1
Gilard, V; Malet-Martino, M; Martino, R1
Doi, Y; Kanazawa, Y; Kuribayashi, H1
Adamiak, RW; Bielecki, L; Fischer, A; Gdaniec, Z; Grabarkiewicz, T; Olejniczak, M1
Heerschap, A; Kamm, YJ; Klomp, DW; Punt, CJ; van Laarhoven, HW1
Berger, MR; Hull, WE; Koroma, S; Lutz, NW; Naser-Hijazi, B1
Chung, YL; Griffiths, JR; Harris, AL; Judson, IR; Leach, MO; Leek, R; Stubbs, M; Troy, H1
Chen, M; Chenevert, TL; Dornfeld, KJ; Gelovani, JT; Hamstra, DA; Lawrence, TS; Lee, KC; Moffat, BA; Rehemtulla, A; Ross, BD; Schepkin, VD; Tychewicz, JM1
Heerschap, A; Kamm, YJ; Punt, CJ; van Laarhoven, HW1
Antonakis, K; Dorange, I; Egron, MJ; Herscovici, J; Komiotis, D; Ollapally, AP1
Desmoulin, F; Gilard, V; Malet-Martino, M; Martino, R3
Lee, JS; MacNaughton, JB; Moewes, A; Wilks, RG1
Heerschap, A; Kamm, Y; Klomp, D; Scheenen, T; van Laarhoven, H1
Inubushi, T; Maki, J; Masuda, C; Morikawa, S; Morita, M; Murakami, K; Tooyama, I1
Chu, PK; Deng, Z; Li, H; Li, P; Li, X; Liu, G; Wu, S; Xu, H; Xu, Z1
Lee, H; Ooya, T1
Bachmeier, E; Finkelberg, A; Galván, V; Linares, JA; López, MM; Mazzeo, MA; Riveros, JA; Valentinuzzi, MC; Wietz, FM1
Cavaliere, A; Probst, KC; Slusarczyk, M; Westwell, AD1
Bozkaya, Y; Demirci, NS; Erdem, GU; Ozdemir, NY; Yazici, O; Zengin, N1
Anklin, C; Arthanari, H; Boeszoermenyi, A; Burdzhiev, NT; Chanev, CD; Chhabra, S; Dubey, A; Gelev, VM; Kovacs, H; Kuprov, I; Petrov, OI; Radeva, DL; Takeuchi, K; Wagner, G; Zhang, M1

Reviews

9 review(s) available for fluorine and fluorouracil

ArticleYear
Some pyrimidines of biological and medicinal interest. I.
    Progress in medicinal chemistry, 1969, Volume: 6

    Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Antimalarials; Antimetabolites; Antithyroid Agents; Bacteria; Bromine; Chlorine; Floxuridine; Fluorine; Fluorouracil; Humans; Iodine; Pyrimethamine; Pyrimidines; Rodenticides; Sulfonamides

1969
In vivo monitoring of fluoropyrimidine metabolites: magnetic resonance spectroscopy in the evaluation of 5-fluorouracil.
    Anti-cancer drugs, 1994, Volume: 5, Issue:3

    Topics: Animals; Clinical Trials as Topic; Drug Evaluation, Preclinical; Fluorine; Fluorouracil; Humans; Magnetic Resonance Spectroscopy; Neoplasms; Neoplasms, Experimental; Pyrimidines

1994
19F-MRS studies of fluorinated drugs in humans.
    Advanced drug delivery reviews, 2000, Mar-15, Volume: 41, Issue:1

    Topics: Fluorine; Fluorouracil; Humans; Magnetic Resonance Spectroscopy; Models, Biological; Neoplasms; Prodrugs

2000
Fluorine nuclear magnetic resonance, a privileged tool for metabolic studies of fluoropyrimidine drugs.
    Current drug metabolism, 2000, Volume: 1, Issue:3

    Topics: Animals; Antimetabolites, Antineoplastic; Fluorine; Fluorouracil; Humans; Magnetic Resonance Spectroscopy; Pyrimidines

2000
Monitoring fluoropyrimidine metabolism in solid tumors with in vivo (19)F magnetic resonance spectroscopy.
    Critical reviews in oncology/hematology, 2005, Volume: 56, Issue:3

    Topics: Animals; Antimetabolites, Antineoplastic; Fluorine; Fluorouracil; Humans; Magnetic Resonance Spectroscopy; Mice; Neoplasms

2005
Fluorine-19 or phosphorus-31 NMR spectroscopy: a suitable analytical technique for quantitative in vitro metabolic studies of fluorinated or phosphorylated drugs.
    Journal of pharmaceutical and biomedical analysis, 2005, Aug-10, Volume: 38, Issue:5

    Topics: Animals; Cyclophosphamide; Fluorine; Fluorouracil; Humans; Hydrocarbons, Fluorinated; In Vitro Techniques; Magnetic Resonance Spectroscopy; Organophosphorus Compounds; Phosphorus Isotopes

2005
Fluorine nuclear magnetic resonance spectroscopy of human biofluids in the field of metabolic studies of anticancer and antifungal fluoropyrimidine drugs.
    Clinica chimica acta; international journal of clinical chemistry, 2006, Volume: 366, Issue:1-2

    Topics: Antifungal Agents; Antimetabolites, Antineoplastic; Body Fluids; Flucytosine; Fluorine; Fluorouracil; Humans; Magnetic Resonance Spectroscopy

2006
Interest of fluorine-19 nuclear magnetic resonance spectroscopy in the detection, identification and quantification of metabolites of anticancer and antifungal fluoropyrimidine drugs in human biofluids.
    Chemotherapy, 2006, Volume: 52, Issue:5

    Topics: Antifungal Agents; Antimetabolites, Antineoplastic; Body Fluids; Flucytosine; Fluorine; Fluorouracil; Humans; Magnetic Resonance Spectroscopy

2006
Fluorinated nucleosides as an important class of anticancer and antiviral agents.
    Future medicinal chemistry, 2017, Volume: 9, Issue:15

    Topics: Antineoplastic Agents; Antiviral Agents; Deoxycytidine; Fluorine; Fluorouracil; Gemcitabine; HIV; Neoplasms; Nucleoside Transport Proteins; Nucleosides; Positron-Emission Tomography

2017

Other Studies

92 other study(ies) available for fluorine and fluorouracil

ArticleYear
Distribution of 18F-5-fluorouracil in tumor-bearing mice and rats.
    International journal of nuclear medicine and biology, 1978, Volume: 5, Issue:1

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Fluorine; Fluorouracil; Leukemia, Experimental; Liver Neoplasms; Mammary Neoplasms, Experimental; Mice; Mice, Inbred AKR; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasm Transplantation; Neoplasms, Experimental; Radioisotopes; Rats; Rats, Inbred BUF; Rats, Inbred F344; Sarcoma, Experimental; Tissue Distribution

1978
[Comparative teratological studies with organic fluroine compounds, their bases and amines].
    Deutsche zahnarztliche Zeitschrift, 1977, Volume: 32, Issue:11

    Topics: Abnormalities, Drug-Induced; Amines; Animals; Deoxycytidine; Female; Fluorides; Fluorides, Topical; Fluorine; Fluorouracil; Mice; Pregnancy

1977
An improved synthesis of 18F-5-fluorouracil.
    The International journal of applied radiation and isotopes, 1979, Volume: 30, Issue:7

    Topics: Fluorine; Fluorouracil; Isotope Labeling; Radioisotopes

1979
Fluorine-19 nuclear magnetic resonance as a probe of the solution structure of mutants of 5-fluorouracil-substituted Escherichia coli valine tRNA.
    Journal of molecular biology, 1992, Oct-20, Volume: 227, Issue:4

    Topics: Acylation; Anticodon; Base Sequence; Escherichia coli; Fluorine; Fluorouracil; Kinetics; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Mutation; Nucleic Acid Conformation; RNA, Bacterial; RNA, Transfer, Val; Solutions; Transcription, Genetic

1992
Correlations between fluorine-19 nuclear magnetic resonance chemical shift and the secondary and tertiary structure of 5-fluorouracil-substituted tRNA.
    Journal of molecular biology, 1992, Oct-20, Volume: 227, Issue:4

    Topics: Acylation; Amino Acid Sequence; Base Sequence; Escherichia coli; Fluorine; Fluorouracil; Kinetics; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Nucleic Acid Conformation; RNA, Bacterial; RNA, Transfer, Val

1992
Metabolism of tegafur in rat liver observed by in vivo 19F magnetic resonance spectroscopy and chromatography.
    Japanese journal of cancer research : Gann, 1992, Volume: 83, Issue:4

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Chromatography, High Pressure Liquid; Fluorine; Fluorouracil; Gas Chromatography-Mass Spectrometry; Liver; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Inbred WKY; Tegafur

1992
Fluorine-19 NMR studies of the thermal unfolding of 5-fluorouracil-substituted Escherichia coli valine transfer RNA.
    FEBS letters, 1991, Dec-16, Volume: 295, Issue:1-3

    Topics: Base Sequence; Escherichia coli; Fluorine; Fluorouracil; Hot Temperature; Magnetic Resonance Spectroscopy; Models, Structural; Molecular Sequence Data; Nucleic Acid Conformation; Nucleic Acid Denaturation; RNA, Transfer, Val; Thermodynamics

1991
Recognition of Escherichia coli valine transfer RNA by its cognate synthetase: a fluorine-19 NMR study.
    Biochemistry, 1991, Feb-12, Volume: 30, Issue:6

    Topics: Base Sequence; Binding Sites; Chromatography; Chromatography, Gel; Durapatite; Escherichia coli; Fluorine; Fluorouracil; Hydroxyapatites; Kinetics; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Molecular Weight; Nucleic Acid Conformation; Protein Conformation; RNA, Transfer, Val; Valine-tRNA Ligase

1991
[In-vivo 19F-MRS study of 5-fluorouracil (5-FU) metabolism on tumors].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1991, Volume: 18, Issue:1

    Topics: Animals; beta-Alanine; Fluorine; Fluorouracil; Liver; Liver Neoplasms, Experimental; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Inbred F344; Rats, Inbred Strains; Sarcoma, Yoshida; Tissue Distribution; Uridine Triphosphate

1991
Kinetic modeling of in vivo--nuclear magnetic resonance spectroscopy data: 5-fluorouracil in liver and liver tumors.
    Clinical pharmacology and therapeutics, 1991, Volume: 49, Issue:5

    Topics: Adult; Aged; beta-Alanine; Female; Fluorine; Fluorouracil; Humans; Least-Squares Analysis; Liver; Liver Neoplasms; Magnetic Resonance Spectroscopy; Male; Middle Aged; Urea

1991
Multinuclear MR investigation of the metabolic response of the murine RIF-1 tumor to 5-fluorouracil chemotherapy.
    Magnetic resonance in medicine, 1991, Volume: 19, Issue:2

    Topics: Animals; beta-Alanine; Female; Fibrosarcoma; Fluorine; Fluorouracil; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C3H; Mice, Inbred Strains; Phosphates; Phosphocreatine; Phosphorus; Regression Analysis; Remission Induction; Skin Neoplasms

1991
pH dependence of 5-fluorouracil uptake observed by in vivo 31P and 19F nuclear magnetic resonance spectroscopy.
    Cancer research, 1991, Oct-15, Volume: 51, Issue:20

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; beta-Alanine; Fibrosarcoma; Fluorine; Fluorouracil; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Phosphorus; Rats; Rats, Inbred Strains; Urea

1991
In vivo measurements of intratumoral metabolism, modulation, and pharmacokinetics of 5-fluorouracil, using 19F nuclear magnetic resonance spectroscopy.
    Cancer research, 1991, Nov-01, Volume: 51, Issue:21

    Topics: Animals; Carcinoma 256, Walker; Fluorine; Fluorouracil; Kinetics; Least-Squares Analysis; Magnetic Resonance Spectroscopy; Male; Methotrexate; Models, Biological; Rats; Rats, Inbred Strains

1991
Real-time follow-up of 5-fluorouracil metabolism in the liver of tumor patients by means of F-19 MR spectroscopy.
    Radiology, 1990, Volume: 174, Issue:1

    Topics: Adult; Aged; beta-Alanine; Female; Fluorine; Fluorouracil; Humans; Liver; Liver Neoplasms; Magnetic Resonance Spectroscopy; Male; Middle Aged; Time Factors

1990
High-performance liquid chromatography with chemiluminescence detection of serum levels of pre-column derivatized fluoropyrimidine compounds.
    Journal of chromatography, 1990, Aug-24, Volume: 530, Issue:1

    Topics: Chromatography, High Pressure Liquid; Coumarins; Floxuridine; Fluorine; Fluorouracil; Humans; Molecular Structure; Pyrimidines; Tegafur; Umbelliferones; Uridine

1990
Human tumor fluorouracil trapping: clinical correlations of in vivo 19F nuclear magnetic resonance spectroscopy pharmacokinetics.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1990, Volume: 8, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Fluorine; Fluorouracil; Half-Life; Humans; Leucovorin; Magnetic Resonance Spectroscopy; Neoplasms

1990
Tumor trapping of 5-fluorouracil: in vivo 19F NMR spectroscopic pharmacokinetics in tumor-bearing humans and rabbits.
    Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:1

    Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Colonic Neoplasms; Female; Fluorine; Fluorouracil; Half-Life; Humans; Liver; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Neoplasms, Experimental; Rabbits; Rectal Neoplasms; Tissue Distribution; Uterine Neoplasms

1990
[Potentialities of fluorine-19 and phosphorus-31 NMR for studying the metabolism and pharmacokinetics of fluorinated or phosphoric antineoplastic agents].
    Bulletin du cancer, 1989, Volume: 76, Issue:8

    Topics: Floxuridine; Fluorine; Fluorouracil; Humans; Ifosfamide; Magnetic Resonance Spectroscopy; Phosphorus

1989
Effects of 5-fluorouracil/guanine wobble base pairs in Z-DNA: molecular and crystal structure of d(CGCGFG).
    Nucleic acids research, 1989, Feb-11, Volume: 17, Issue:3

    Topics: Base Composition; Crystallography; DNA; Fluorine; Fluorouracil; Guanine; Molecular Structure; Nucleic Acid Conformation

1989
Noninvasive fluorine-19 NMR study of fluoropyrimidine metabolism in cell cultures of human pancreatic and colon adenocarcinoma.
    Cancer chemotherapy and pharmacology, 1986, Volume: 18, Issue:1

    Topics: Adenocarcinoma; Cells, Cultured; Colonic Neoplasms; Floxuridine; Fluorine; Fluorouracil; Humans; Macromolecular Substances; Magnetic Resonance Spectroscopy; Pancreatic Neoplasms; Spectrum Analysis

1986
Equilibrium between a wobble and ionized base pair formed between fluorouracil and guanine in DNA as studied by proton and fluorine NMR.
    The Journal of biological chemistry, 1988, Oct-15, Volume: 263, Issue:29

    Topics: Base Composition; DNA; Fluorine; Fluorouracil; Guanine; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Molecular Structure; Nucleic Acid Conformation

1988
Fluorine-19 nuclear magnetic resonance study of codon-anticodon interaction in 5-fluorouracil-substituted E. coli transfer RNAs.
    Nucleic acids research, 1986, Jun-11, Volume: 14, Issue:11

    Topics: Anticodon; Base Sequence; Codon; Escherichia coli; Fluorine; Fluorouracil; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation; RNA, Messenger; RNA, Transfer; RNA, Transfer, Amino Acyl

1986
Fluorine-19 nuclear magnetic resonance studies of the structure of 5-fluorouracil-substituted Escherichia coli transfer RNA.
    Biochemistry, 1986, Sep-23, Volume: 25, Issue:19

    Topics: Base Sequence; Escherichia coli; Fluorine; Fluorouracil; Hydrogen-Ion Concentration; Magnesium; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation; RNA, Transfer, Amino Acyl

1986
Complete urinary excretion profile of 5-fluorouracil during a six-day chemotherapeutic schedule, as resolved by 19F nuclear magnetic resonance.
    Clinical chemistry, 1985, Volume: 31, Issue:6

    Topics: beta-Alanine; Fluorine; Fluorouracil; Humans; Magnetic Resonance Spectroscopy; Radioisotopes; Urea

1985
Comparative radiopharmacokinetics of 18F-5-fluorouracil administered i.v. to rats bearing a mammary tumor.
    International journal of nuclear medicine and biology, 1985, Volume: 12, Issue:1

    Topics: Adenocarcinoma; Animals; Female; Fluorine; Fluorouracil; Injections, Intravenous; Kinetics; Mammary Neoplasms, Experimental; Radioisotopes; Rats; Rats, Inbred F344; Rats, Inbred Strains; Species Specificity

1985
5-Fluoropyrimidine-resistant mutants of pneumococcus.
    Journal of bacteriology, 1973, Volume: 113, Issue:3

    Topics: Carbon Isotopes; Chromatography, Thin Layer; Cytosine; Deoxyribonucleosides; Drug Resistance, Microbial; Floxuridine; Fluorine; Fluorouracil; Mutation; N-Glycosyl Hydrolases; Pentosyltransferases; Phosphoric Monoester Hydrolases; Phosphotransferases; Pyrimidines; Ribonucleosides; Streptococcus pneumoniae; Transformation, Genetic; Uridine

1973
Steroid induction of porphyrin synthesis in liver cell culture. II. The effects of heme, uridine diphosphate glucuronic acid, and inhibitors of nucleic acid and protein synthesis on the induction process.
    The Journal of biological chemistry, 1968, Jan-25, Volume: 243, Issue:2

    Topics: Acetates; Amides; Animals; Azaserine; Azo Compounds; Chick Embryo; Culture Techniques; Cycloheximide; Dactinomycin; Floxuridine; Fluorine; Fluorouracil; Glucosamine; Glucose; Glucuronates; Hexosephosphates; Leucine; Liver; Mitomycins; Organometallic Compounds; Phenylalanine; Porphyrias; Porphyrins; Pregnanes; Puromycin; Uracil Nucleotides

1968
[Comparative in vitro studies with 5-fluorouracil and some of its derivatives].
    Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1969, Volume: 350, Issue:6

    Topics: Acyltransferases; Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Cell-Free System; Depression, Chemical; DNA Nucleotidyltransferases; DNA, Neoplasm; Floxuridine; Fluorine; Fluorouracil; In Vitro Techniques; Leucine; Neoplasm Proteins; Nucleotides; RNA, Neoplasm; Thymidine; Uridine

1969
Determinants of responsiveness to 5-fluorouridine in transplantable murine leukemias.
    Molecular pharmacology, 1971, Volume: 7, Issue:2

    Topics: Animals; Antineoplastic Agents; Biodegradation, Environmental; Biological Transport; Cell Line; Cell Survival; Cells, Cultured; Deoxyuridine; DNA Replication; DNA, Neoplasm; Drug Resistance; Floxuridine; Fluorine; Fluorouracil; Leukemia, Experimental; Mice; Neoplasm Transplantation; Pentosyltransferases; Phosphotransferases; Uridine

1971
Incorporation of thymidine after administration of fluorouracil and fluorouridine to adult and embryo mice.
    Research communications in chemical pathology and pharmacology, 1971, Volume: 2, Issue:6

    Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Cleft Palate; Dose-Response Relationship, Drug; Embryo, Mammalian; Female; Fetus; Floxuridine; Fluorine; Fluorouracil; Mice; Mice, Inbred Strains; Pregnancy; Rats; Thymidine; Time Factors; Tritium; Uridine

1971
The nucleotides of fluorinated pyrimidines and their biological activities.
    Ciba Foundation symposium, 1971, Volume: 2

    Topics: Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Cells, Cultured; Chromatography, Ion Exchange; Floxuridine; Fluorine; Fluorouracil; Formates; HeLa Cells; Kinetics; Mice; Models, Biological; Pyrimidine Nucleotides; Pyrimidines; RNA; Structure-Activity Relationship; Thymidylate Synthase; Thymine; Vaccinia virus

1971
Inhibition of ribosomal ribonucleic acid maturation in Novikoff hepatoma cells by 5-fluorouracil and 5-fluorouridine.
    The Journal of biological chemistry, 1973, Jan-10, Volume: 248, Issue:1

    Topics: Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Cell Line; Electrophoresis; Fluorine; Fluorouracil; Kinetics; Liver Neoplasms; Methionine; Methylation; Neoplasms, Experimental; Rats; RNA, Ribosomal; Tritium; Uracil; Uridine

1973
Genetic studies of respiratory syncytial virus temperature-sensitive mutants.
    Archiv fur die gesamte Virusforschung, 1973, Volume: 41, Issue:3

    Topics: Alkanesulfonates; Carcinoma; Cell Line; Crosses, Genetic; Fluorine; Fluorouracil; Genetic Complementation Test; Genetics, Microbial; HeLa Cells; Heterozygote; Humans; Laryngeal Neoplasms; Mutagens; Mutation; Recombination, Genetic; Respiratory Syncytial Viruses; Temperature; Uridine; Virus Replication

1973
Electron microscopic studies of respiratory syncytial temperature-sensitive mutants.
    Archiv fur die gesamte Virusforschung, 1973, Volume: 41, Issue:3

    Topics: Alkanesulfonates; Antigens, Viral; Cell Membrane; Cytopathogenic Effect, Viral; Cytoplasm; Fluorescent Antibody Technique; Fluorine; Fluorouracil; Genetic Complementation Test; Genetics, Microbial; HeLa Cells; Humans; Inclusion Bodies, Viral; Microscopy, Electron; Morphogenesis; Mutagens; Mutation; Respiratory Syncytial Viruses; Temperature; Uridine; Virus Replication

1973
Identification of 5-fluorocytidine in RNA from Escherichia coli grown in the presence of 5-fluorouracil.
    FEBS letters, 1973, Jun-01, Volume: 32, Issue:2

    Topics: Carbon Radioisotopes; Chromatography, Gel; Chromatography, Paper; Chromatography, Thin Layer; Cytidine; Escherichia coli; Fluorine; Fluorouracil; Molecular Weight; Phosphoric Diester Hydrolases; RNA, Bacterial; RNA, Ribosomal; Spectrophotometry, Ultraviolet; Tritium; Venoms

1973
Isolation and partial characterization of regulatory mutants of the pyrimidine pathway in Salmonella typhimurium.
    Journal of bacteriology, 1972, Volume: 109, Issue:3

    Topics: Aspartic Acid; Centrifugation, Density Gradient; Chromosome Mapping; Culture Media; Cytosine Nucleotides; Drug Resistance, Microbial; Feedback; Fluorine; Fluorouracil; Genetics, Microbial; Mutation; Nucleotides; Orotic Acid; Oxidoreductases; Phosphorus; Phosphorus Isotopes; Pyrimidines; Salmonella typhimurium; Transduction, Genetic; Transferases; Uridine

1972
Fungistatic activity, uptake and incorporation of 5-fluorocytosine in Candida albicans, as influenced by pyrimidines and purines. I. Reversal experiments.
    Pathologia et microbiologia, 1973, Volume: 39, Issue:2

    Topics: Antifungal Agents; Candida albicans; Carbon Isotopes; Cytosine; Drug Antagonism; Fluorine; Fluorouracil; Purines; Pyrimidines; Saccharomyces cerevisiae; Species Specificity; Yeasts

1973
The synthesis of 18 F-5-fluorouracil. VII.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1973, Volume: 14, Issue:1

    Topics: Fluorine; Fluorouracil; Isotope Labeling; Methods; Neon; Radioisotopes

1973
The role of thymidylate synthetase inhibitors in bromodeoxyuridine-induced neoplasia in Drosophila.
    Cancer research, 1973, Volume: 33, Issue:11

    Topics: Animals; Bromodeoxyuridine; Centrifugation, Density Gradient; DNA; Drosophila; Fluorine; Fluorouracil; Idoxuridine; Larva; Methotrexate; Methyltransferases; Neoplasms, Experimental; Thymidine; Thymidylate Synthase; Tritium

1973
A convenient synthesis of 5-fluorouracil.
    The Journal of organic chemistry, 1972, Jan-28, Volume: 37, Issue:2

    Topics: Fluorine; Fluorouracil; Methods; Uracil

1972
Studies on conidial germination and appressorium formation by Colletotrichum trifolii Bain & Essary.
    Canadian journal of microbiology, 1972, Volume: 18, Issue:8

    Topics: Atmosphere; Bromouracil; Carbon Dioxide; Cycloheximide; Dactinomycin; Fluorine; Fluorouracil; Fungi; Mitosporic Fungi; Phenylalanine; Spores; Spores, Fungal; Surface-Active Agents; Temperature

1972
18 F recoil labeling.
    The International journal of applied radiation and isotopes, 1972, Volume: 23, Issue:8

    Topics: Deuterium; Fluorine; Fluorouracil; Isotope Labeling; Methods; Neon; Radioisotopes; Radionuclide Imaging; Uracil

1972
The effect of prednisolone and other factors on the catabolism of 5-fluorouracil in rats.
    The Journal of laboratory and clinical medicine, 1971, Volume: 78, Issue:3

    Topics: Animals; Autoradiography; Carbon Dioxide; Carbon Isotopes; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chromatography, Ion Exchange; Drug Interactions; Fluorine; Fluorouracil; Male; Phenobarbital; Prednisolone; Propionates; Rats; Urea

1971
Fluoxydin. (Preliminary report on clinical evaluation).
    Neoplasma, 1971, Volume: 18, Issue:5

    Topics: Antineoplastic Agents; Drug Tolerance; Fluorine; Fluorouracil; Humans; Neoplasms; Pyrimidines

1971
Genetic and physiological aspects of resistance to 5-fluoropyrimidines in Saccharomyces cerevisiae.
    Journal of bacteriology, 1970, Volume: 102, Issue:3

    Topics: Aminohydrolases; Carbon Isotopes; Cell-Free System; Chromatography, Paper; Chromatography, Thin Layer; Chromosome Mapping; Cytosine; Drug Resistance, Microbial; Fluorine; Fluorouracil; Genetics, Microbial; Membrane Transport Proteins; Mutation; Phosphorus Isotopes; Phosphotransferases; Saccharomyces; Spectrophotometry; Transferases; Uracil; Uridine

1970
[tRNA's from yeast having incorporated 5-fluorouracil arising from in vivo deamination of 5-fluorocytosine].
    Bulletin de la Societe de chimie biologique, 1970, Mar-31, Volume: 52, Issue:2

    Topics: Adenine; Amino Acids; Aminohydrolases; Chromatography, Paper; Cytosine; Deamination; Fluorine; Fluorouracil; Guanine; Mutation; RNA, Transfer; Saccharomyces; Spectrophotometry; Ultraviolet Rays; Uracil

1970
Some observations on the experimental production of acute neuroaxonal and synaptosomal dystrophy.
    Acta neuropathologica, 1971, Volume: 5

    Topics: Animals; Axons; Brain; Cats; Citrates; Citric Acid Cycle; Cyanides; Demyelinating Diseases; Fluorine; Fluoroacetates; Fluorouracil; Methionine; Microscopy, Electron; Mitochondrial Swelling; Oxidative Phosphorylation; Pyridines; Spinal Cord; Strychnine; Synapses

1971
Fluorinated pyrimidine aldehydes. Inhibition of nucleic acid and protein biosynthesis in Ehrlich ascites carcinoma cells in vitro.
    Journal of medicinal chemistry, 1968, Volume: 11, Issue:3

    Topics: Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Chromatography, Ion Exchange; Chromatography, Thin Layer; DNA; Female; Fluorine; Fluorouracil; Formates; Glycine; In Vitro Techniques; Mice; Orotic Acid; Phenylalanine; Protein Biosynthesis; Purines; Pyrimidines; RNA; Thymidine; Tritium

1968
A direct synthesis of 1-beta-D-arabinofuranosyl-5-fluorocytosine.
    Journal of medicinal chemistry, 1967, Volume: 10, Issue:5

    Topics: Antineoplastic Agents; Arabinose; Cytosine; Fluorine; Fluorouracil; Nucleosides; Pyrimidines; Thiouracil; Uracil

1967
Inducible synthesis of bacterial luciferase: specificity and kinetics of induction.
    Journal of bacteriology, 1967, Volume: 94, Issue:5

    Topics: Amines; Amino Acids; Ammonium Chloride; Arginine; Azo Compounds; Bacteria; Bacterial Proteins; Carbamates; Carbon Isotopes; Chloramphenicol; Enzyme Induction; Fluorine; Fluorouracil; Guanidines; Kinetics; Light; Luciferases; Marine Biology; Nitrates; Phenylalanine; Propylamines; Puromycin; RNA, Messenger; Urea

1967
Nucleosides. XXXVII. 5,6-substituted 5-fluorodihydropyrimidines and their 2'-deoxyribonucleosides.
    Journal of medicinal chemistry, 1967, Volume: 10, Issue:1

    Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Chemistry, Organic; Chromatography, Paper; Fluorine; Fluorouracil; Hydrocarbons, Halogenated; Leukemia; Mice; Nucleosides; Organic Chemistry Phenomena; Pyrimidines; Sarcina

1967
The antineoplastic and biochemical effects of some 5-fluoropyrimidines.
    Cancer research, 1967, Volume: 27, Issue:11

    Topics: Adenine Nucleotides; Animals; Antineoplastic Agents; Carbon Isotopes; DNA, Neoplasm; Female; Fluorine; Fluorouracil; Guanine Nucleotides; Injections, Intraperitoneal; Mice; Pyrimidines; RNA, Neoplasm; Sarcoma 180; Uracil Nucleotides

1967
Adjuvant and palliative treatment of colorectal cancer with fluorinated pyrimidines. A pharmacological and clinical review.
    Acta chirurgica Scandinavica. Supplementum, 1981, Volume: 504

    Topics: Adult; Aged; Antineoplastic Agents; Colonic Neoplasms; Female; Fluorine; Fluorouracil; Humans; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Palliative Care; Prognosis; Pyrimidines; Rectal Neoplasms; Uridine

1981
Studies on 18F-labeled pyrimidines. Tumor uptakes of 18F-5-fluorouracil, 18F-5-fluorouridine, and 18F-5-fluorodeoxyuridine in animals.
    European journal of nuclear medicine, 1983, Volume: 8, Issue:6

    Topics: Animals; Autoradiography; Floxuridine; Fluorine; Fluorouracil; Liver Neoplasms, Experimental; Male; Radioisotopes; Rats; Rats, Inbred Strains; Tissue Distribution; Tomography, Emission-Computed; Uridine

1983
Studies on 18F-labeled pyrimidines. II. Metabolic investigation of 18F-5-fluorouracil, 18F-5-fluoro-2'-deoxyuridine and 18F-5-fluorouridine in rats.
    European journal of nuclear medicine, 1984, Volume: 9, Issue:4

    Topics: Animals; Bile; Floxuridine; Fluorine; Fluorouracil; Radioisotopes; Rats; Rats, Inbred Strains; Uridine

1984
Syntheses of 18F-labeled pyrimidines and their usefulness for tumor imaging.
    Nucleic acids symposium series, 1984, Issue:15

    Topics: Animals; Chromatography, High Pressure Liquid; Floxuridine; Fluorine; Fluorouracil; Glioma; Liver Neoplasms, Experimental; Mammary Neoplasms, Experimental; Mice; Radioisotope Dilution Technique; Radioisotopes; Radionuclide Imaging; Rats; Uridine

1984
Metabolic and distribution studies with radiolabeled 5-fluorouracil.
    Nuklearmedizin. Nuclear medicine, 1982, Volume: 21, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Animals; Biotransformation; Breast Neoplasms; Carcinoma, Hepatocellular; Colonic Neoplasms; Female; Fluorine; Fluorouracil; Humans; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Neoplasms; Radioisotopes; Rats; Tissue Distribution

1982
A simple synthesis of 18F-labelled 5-fluorouracil using acetylhypofluorite.
    International journal of nuclear medicine and biology, 1984, Volume: 11, Issue:2

    Topics: Acetates; Esters; Fluorine; Fluorouracil; Radioisotopes

1984
5-fluorouracil metabolism monitored in vivo by 19F NMR.
    British journal of cancer, 1984, Volume: 50, Issue:1

    Topics: Animals; Female; Fluorine; Fluorouracil; Liver; Lung Neoplasms; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL

1984
Dosimetry and preliminary human studies of 18F-5-fluorouracil.
    International journal of nuclear medicine and biology, 1982, Volume: 9, Issue:1

    Topics: Animals; Breast Neoplasms; Colonic Neoplasms; Drug Evaluation; Fluorine; Fluorouracil; Half-Life; Humans; Kidney; Liver; Liver Neoplasms; Neoplasms, Experimental; Prognosis; Radiation Dosage; Radioisotopes; Rats; Tissue Distribution; Urinary Bladder

1982
18F-5-fluorouracil studies in humans and animals.
    International journal of radiation oncology, biology, physics, 1980, Volume: 6, Issue:4

    Topics: Adult; Aged; Animals; Female; Fluorine; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Radioisotopes; Radionuclide Imaging; Rats; Tissue Distribution

1980
Stereochemistry of tRNA(m5U54)-methyltransferase catalysis: 19F NMR spectroscopy of an enzyme-FUraRNA covalent complex.
    Biochemistry, 1995, Feb-28, Volume: 34, Issue:8

    Topics: Base Sequence; Catalysis; Escherichia coli; Fluorine; Fluorouracil; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Nucleic Acid Conformation; RNA, Bacterial; Stereoisomerism; Substrate Specificity; tRNA Methyltransferases

1995
Somatostatin analogue octreotide modulates metabolism and effects of 5-fluorouracil and 5-fluorouridine in human colon cancer spheroids.
    Cancer letters, 1994, Oct-28, Volume: 86, Issue:1

    Topics: Adenocarcinoma; Amino Acid Sequence; Cell Cycle; Colonic Neoplasms; DNA Damage; DNA, Neoplasm; Drug Interactions; Fluorine; Fluorouracil; G1 Phase; Humans; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Octreotide; Receptors, Somatostatin; Resting Phase, Cell Cycle; RNA, Ribosomal; S Phase; Tumor Cells, Cultured; Uridine

1994
In vivo 19F NMR comparative study of 5-fluorouracil, 1-(2-tetrahydrofuryl)-5-fluorouracil (FT) and an FT-uracil coadministration system in mouse tumors.
    Chemical & pharmaceutical bulletin, 1994, Volume: 42, Issue:4

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Fluorine; Fluorouracil; Liver; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred ICR; Neoplasm Transplantation; Sarcoma 180; Tegafur; Uracil

1994
Effect of modulators on 5-fluorouracil metabolite patterns in murine colon carcinoma determined by in vitro 19F nuclear magnetic resonance spectroscopy.
    Cancer research, 1994, Aug-15, Volume: 54, Issue:16

    Topics: Animals; Aspartic Acid; Colonic Neoplasms; Female; Fluorine; Fluorouracil; Interferon-alpha; Leucovorin; Magnetic Resonance Spectroscopy; Methotrexate; Mice; Mice, Inbred C57BL; Phosphonoacetic Acid; Rats; Tumor Cells, Cultured

1994
The binding of 5-fluorouracil to native and modified human serum albumin: UV, CD, and 1H and 19F NMR investigation.
    Journal of pharmaceutical and biomedical analysis, 1995, Volume: 13, Issue:9

    Topics: Acetylation; Antimetabolites, Antineoplastic; Circular Dichroism; Fluorine; Fluorouracil; Humans; Hydrogen; Lysine; Magnetic Resonance Spectroscopy; Protein Binding; Serum Albumin; Spectrophotometry, Ultraviolet

1995
Simultaneous 3D NMR spectroscopy of fluorine and phosphorus in human liver during 5-fluorouracil chemotherapy.
    Magnetic resonance in medicine, 1996, Volume: 35, Issue:6

    Topics: Adult; Antimetabolites, Antineoplastic; Fluorine; Fluorouracil; Humans; Liver; Magnetic Resonance Spectroscopy; Male; Phantoms, Imaging; Phosphorus

1996
5-Fluorouracil metabolite patterns in viable and necrotic tumor areas of murine colon carcinoma determined by 19F NMR spectroscopy.
    Magnetic resonance in medicine, 1996, Volume: 36, Issue:3

    Topics: Animals; Colonic Neoplasms; Female; Fluorine; Fluorouracil; Humans; Magnetic Resonance Spectroscopy; Mice; Necrosis

1996
Simultaneous 3D NMR spectroscopy of proton-decoupled fluorine and phosphorus in human liver during 5-fluorouracil chemotherapy.
    Magnetic resonance in medicine, 1997, Volume: 37, Issue:2

    Topics: Absorption; Adult; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Colorectal Neoplasms; Fluorine; Fluorouracil; Humans; Hydrogen; Image Enhancement; Liver; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Phantoms, Imaging; Phosphorus; Time Factors

1997
Measurement of plasma 5-fluorouracil by high-performance liquid chromatography with comparison of results to tissue drug levels observed using in vivo 19F magnetic resonance spectroscopy in patients on a protracted venous infusion with or without interfer
    Annals of oncology : official journal of the European Society for Medical Oncology, 1996, Volume: 7, Issue:1

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chromatography, High Pressure Liquid; Clinical Trials, Phase II as Topic; Female; Fluorine; Fluorouracil; Humans; Infusions, Intravenous; Interferon-alpha; Magnetic Resonance Spectroscopy; Male; Randomized Controlled Trials as Topic

1996
Superiority of hepatic arterial infusion in preventing catabolism of 5-FU compared with portal vein infusion revealed by an in vivo 19F NMR study.
    Cancer chemotherapy and pharmacology, 1998, Volume: 42, Issue:4

    Topics: Animals; Antimetabolites, Antineoplastic; beta-Alanine; Fluorine; Fluorouracil; Hepatic Artery; Infusions, Intra-Arterial; Infusions, Intravenous; Isotopes; Magnetic Resonance Spectroscopy; Male; Portal Vein; Rats; Rats, Wistar; Tail

1998
Intratumoral conversion of 5-fluorocytosine to 5-fluorouracil by monoclonal antibody-cytosine deaminase conjugates: noninvasive detection of prodrug activation by magnetic resonance spectroscopy and spectroscopic imaging.
    Cancer research, 1998, Sep-15, Volume: 58, Issue:18

    Topics: Animals; Female; Flucytosine; Fluorine; Fluorouracil; Humans; Magnetic Resonance Spectroscopy; Mice; Prodrugs

1998
Intra- and extracellular fluorouracil uptake: assessment with contrast-enhanced metabolic F-19 MR imaging.
    Radiology, 1998, Volume: 209, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Contrast Media; Fluorine; Fluorouracil; Gadolinium DTPA; Humans; Liver Neoplasms, Experimental; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Neoplasm Transplantation; Phantoms, Imaging; Rats; Rats, Inbred ACI; Tissue Distribution

1998
Alterations of intratumoral pharmacokinetics of 5-fluorouracil in head and neck carcinoma during simultaneous radiochemotherapy.
    Cancer research, 1999, May-15, Volume: 59, Issue:10

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; beta-Alanine; Biotransformation; Carboplatin; Carcinoma, Squamous Cell; Combined Modality Therapy; Drug Administration Schedule; Female; Fluorine; Fluorouracil; Head and Neck Neoplasms; Humans; Isotopes; Lymphatic Metastasis; Magnetic Resonance Imaging; Male; Middle Aged

1999
A preliminary study for clinical pharmacokinetics of oral fluorine anticancer medicines using the commercial MRI system 19F-MRS.
    The British journal of radiology, 1999, Volume: 72, Issue:858

    Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Digestive System Neoplasms; Female; Fluorine; Fluorouracil; Humans; Liver; Magnetic Resonance Spectroscopy; Male; Middle Aged

1999
Enhancement of 5-fluorouracil anabolism by methotrexate and trimetrexate in two rat solid tumor models, Walker 256 carcinosarcoma and Novikoff hepatoma, as evaluated by 19F-magnetic resonance spectroscopy.
    Cancer investigation, 2000, Volume: 18, Issue:1

    Topics: Animals; Carcinoma 256, Walker; Drug Administration Schedule; Fluorine; Fluorouracil; Kinetics; Liver Neoplasms, Experimental; Magnetic Resonance Spectroscopy; Male; Methotrexate; Rats; Rats, Sprague-Dawley; Trimetrexate

2000
1H decoupling for in vivo (19)F MRS studies using the time-share modulation method on a clinical 1.5 T NMR system.
    Magnetic resonance in medicine, 2000, Volume: 44, Issue:1

    Topics: Antimetabolites, Antineoplastic; Computer Simulation; Finite Element Analysis; Fluorine; Fluorouracil; Humans; Isotopes; Magnetic Resonance Spectroscopy; Neoplasms; Time Factors

2000
Application of (19)F chemical shift imaging in studies of mice with orally administered 5-fluorouracil.
    Magnetic resonance in medicine, 2001, Volume: 46, Issue:5

    Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Female; Fluorine; Fluorouracil; Image Processing, Computer-Assisted; Intestine, Small; Magnetic Resonance Imaging; Mice; Mice, Inbred C3H; Neoplasms, Experimental

2001
The bulge region of HIV-1 TAR RNA binds metal ions in solution.
    Nucleic acids research, 2002, Oct-01, Volume: 30, Issue:19

    Topics: Arginine; Binding Sites; Binding, Competitive; Calcium; Cobalt; Fluorine; Fluorouracil; Gene Products, tat; HIV-1; Humans; Magnesium; Magnetic Resonance Spectroscopy; Metals; Nucleic Acid Conformation; RNA, Viral; tat Gene Products, Human Immunodeficiency Virus

2002
In vivo monitoring of capecitabine metabolism in human liver by 19fluorine magnetic resonance spectroscopy at 1.5 and 3 Tesla field strength.
    Cancer research, 2003, Nov-15, Volume: 63, Issue:22

    Topics: Aged; Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Female; Floxuridine; Fluorine; Fluorouracil; Humans; Liver; Liver Neoplasms; Magnetic Resonance Spectroscopy; Male; Middle Aged; Prodrugs

2003
Fluoropyrimidine chemotherapy in a rat model: comparison of fluorouracil metabolite profiles determined by high-field 19F-NMR spectroscopy of tissues ex vivo with therapy response and toxicity for locoregional vs systemic infusion protocols.
    NMR in biomedicine, 2004, Volume: 17, Issue:3

    Topics: Animals; Antimetabolites, Antineoplastic; Data Interpretation, Statistical; Drug Therapy; Female; Fluorine; Fluorouracil; Humans; Neoplasm Transplantation; Nuclear Magnetic Resonance, Biomolecular; Random Allocation; Rats; Rats, Sprague-Dawley; Sarcoma; Survival Rate

2004
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Jun-01, Volume: 10, Issue:11

    Topics: Animals; Antimetabolites, Antineoplastic; Capecitabine; Cell Line, Tumor; Deoxycytidine; DNA, Complementary; Fluorine; Fluorouracil; Humans; Immunohistochemistry; Magnetic Resonance Spectroscopy; Mice; Mice, Nude; Phantoms, Imaging; Temperature; Thymidine Phosphorylase; Time Factors; Urinary Bladder Neoplasms

2004
The use of 19F spectroscopy and diffusion-weighted MRI to evaluate differences in gene-dependent enzyme prodrug therapies.
    Molecular therapy : the journal of the American Society of Gene Therapy, 2004, Volume: 10, Issue:5

    Topics: Animals; Antineoplastic Agents; Artificial Gene Fusion; Brain; Cytosine Deaminase; Diffusion Magnetic Resonance Imaging; Flucytosine; Fluorine; Fluorodeoxyuridylate; Fluorouracil; Gene Expression; Genetic Therapy; Magnetic Resonance Spectroscopy; Neoplasms; Optic Nerve Glioma; Pentosyltransferases; Prodrugs; Rats; Transduction, Genetic

2004
New short route to unsaturated fluoroketonucleosides: case of 5-fluoro-1-(6-O-acetyl-3,4-di-deoxy-3-fluoro-beta-D-glycero-hex-3-eno-pyranos-2-ulosyl) uracil.
    Nucleosides, nucleotides & nucleic acids, 2005, Volume: 24, Issue:4

    Topics: Chromatography, Thin Layer; Fluorine; Fluorouracil; Immunosuppressive Agents; Ketones; Magnetic Resonance Spectroscopy; Models, Chemical; Nucleosides; Uracil

2005
Experimental and theoretical investigation of the electronic structure of 5-fluorouracil compounds.
    The journal of physical chemistry. B, 2006, Sep-21, Volume: 110, Issue:37

    Topics: Antimetabolites, Antineoplastic; Carbon; Chemistry, Pharmaceutical; Chemistry, Physical; Electronics; Electrons; Fluorine; Fluorouracil; Models, Molecular; Molecular Conformation; Nitrogen; Oxygen; Spectrometry, X-Ray Emission; Spectrophotometry; X-Rays

2006
Quantitative 19F MR spectroscopy at 3 T to detect heterogeneous capecitabine metabolism in human liver.
    NMR in biomedicine, 2007, Volume: 20, Issue:5

    Topics: Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Fluorine; Fluorouracil; Humans; Liver; Magnetic Resonance Spectroscopy

2007
Fluorine-19 fast recovery fast spin echo imaging for mapping 5-fluorouracil.
    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 2007, Volume: 6, Issue:4

    Topics: Animals; Antimetabolites, Antineoplastic; Fluorine; Fluorouracil; Magnetic Resonance Spectroscopy; Male; Phantoms, Imaging; Rats; Rats, Wistar; Sensitivity and Specificity

2007
Magnetite-loaded fluorine-containing polymeric micelles for magnetic resonance imaging and drug delivery.
    Biomaterials, 2012, Volume: 33, Issue:10

    Topics: Animals; Cell Death; Cell Survival; Chromatography, Gel; Drug Delivery Systems; Fluorine; Fluorouracil; HeLa Cells; Humans; Hydrodynamics; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Magnetite Nanoparticles; Methacrylates; Mice; Micelles; Organ Specificity; Polyethylene Glycols; Spectroscopy, Fourier Transform Infrared; Staining and Labeling; Surface Tension; Surface-Active Agents; Thermogravimetry; X-Ray Diffraction

2012
19F-NMR, 1H-NMR, and fluorescence studies of interaction between 5-fluorouracil and polyglycerol dendrimers.
    The journal of physical chemistry. B, 2012, Oct-11, Volume: 116, Issue:40

    Topics: Dendrimers; Fluorescence; Fluorine; Fluorouracil; Glycerol; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Polymers; Protons

2012
Analysis of saliva samples from oncological patients treated with 5-fluorouracil and leucovorin calcium by scanning electron microscopy with energy dispersive system.
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2013, Volume: 42, Issue:10

    Topics: Administration, Intravenous; Adult; Antimetabolites, Antineoplastic; Calcium; Carcinoma; Colonic Neoplasms; Crystallography; Electron Probe Microanalysis; Female; Fluorine; Fluorouracil; Follow-Up Studies; Humans; Leucovorin; Male; Microscopy, Electron, Scanning; Middle Aged; Mouth Mucosa; Saliva; Spectrometry, X-Ray Emission; Stomatitis; Vitamin B Complex

2013
5-fluorouracil, leucovorin, and irinotecan (FOLFIRI) as a third-line chemotherapy treatment in metastatic gastric cancer, after failure of fluoropyrimidine, platinum, anthracycline, and taxane.
    Bosnian journal of basic medical sciences, 2018, May-20, Volume: 18, Issue:2

    Topics: Adult; Aged; Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Disease-Free Survival; Female; Fluorine; Fluorouracil; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Leucovorin; Male; Middle Aged; Multivariate Analysis; Neoplasm Metastasis; Patient Safety; Platinum; Pyrimidines; Stomach Neoplasms; Taxoids; Treatment Outcome

2018
Aromatic
    Nature methods, 2019, Volume: 16, Issue:4

    Topics: Carbon Isotopes; DNA; Escherichia coli; Fluorine; Fluorouracil; Magnetic Fields; Molecular Weight; Mutagenesis, Site-Directed; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acids; Proteasome Endopeptidase Complex; Proteins; Thermoplasma

2019