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fluorides and guanosine diphosphate

fluorides has been researched along with guanosine diphosphate in 94 studies

Research

Studies (94)

TimeframeStudies, this research(%)All Research%
pre-199014 (14.89)18.7374
1990's50 (53.19)18.2507
2000's26 (27.66)29.6817
2010's3 (3.19)24.3611
2020's1 (1.06)2.80

Authors

AuthorsStudies
Cassel, D; Eckstein, F; Levkovitz, H; Lowe, M; Selinger, Z1
Gruenert, DC; Kizer, N; Schwiebert, EM; Stanton, BA1
Biondi, C; Buzzi, M; Campi, AL; Cavallaro, R; Ferretti, ME; Pareschi, MC1
Brown, KO; Hepler, JR; Smrcka, AV; Sternweis, PC1
Cerione, RA; Phillips, WJ1
Andersson, T; Bengtsson, T; Särndahl, E; Stendahl, O1
Fennell, DF; Kurrus, JA; McIntyre, TM; Prescott, SM; Whatley, RE; Zimmerman, GA1
Teitelbaum, I1
Antonny, B; Bigay, J; Chabre, M1
Kirkwood, A; Lisman, JE; Weiner, D1
Carlier, MF; Didry, D; Pantaloni, D; Simon, C1
Carlier, MF; Combeau, C1
Bigay, J; Chabre, M; Deterre, P; Pfister, C2
Ramkumar, V; Stiles, GL1
Hasegawa-Sasaki, H; Lutz, F; Sasaki, T1
Beiderman, B; Bourne, HR; Masters, SB; Miller, RT; Sullivan, KA1
Aurbach, GD; Downs, RW; Reen, S; Singer, M; Spiegel, AM1
Bourne, HR; Farfel, Z; Johnson, GL; Kaslow, HR1
Kempner, E; Lad, PM; Nielsen, TB; Preston, MS; Rodbell, M; Schlegel, W1
Goldhammer, A; Wolff, J1
Birnbaumer, L; Iyengar, R1
Cerione, RA; Erickson, JW; Mittal, R1
Fujishiro, N; Imanaga, I; Inoue, M1
Bobkov, AA; Levitsky, DI1
Hicks, JL; Salter, MW1
Enomoto, K; Maeno, T1
Frangos, JA; Jo, H; Kuchan, MJ1
Birnbaumer, L; Codina, J1
Hamm, HE; Lambright, DG; Noel, JP; Sigler, PB; Sondek, J1
Makhlouf, GM; Murthy, KS1
Berghuis, AM; Coleman, DE; Gilman, AG; Lee, E; Linder, ME; Sprang, SR1
Inanobe, A; Katada, T; Kurachi, Y; Terzic, A; Tung, RT1
Alexandropoulos, K; Foster, DA; Jiang, H; Song, J1
Chabre, M; Chardin, P; Faurobert, E; Otto-Bruc, A1
Bosenberg, MW; Massagué, J; Pandiella, A1
Antonny, B; Bigay, J; Chabre, M; Higashijima, T; Sukumar, M1
Carter, LL; Redelmeier, TE; Schmid, SL; Woollenweber, LA1
Augustine, GJ; Doroshenko, PA; Hess, SD1
Carlier, MF; Melki, R1
Rupnik, M; Zorec, R1
Ahmadian, MR; Goody, RS; Mittal, R; Wittinghofer, A1
Andersson, T; Bokoch, GM; Boulay, F; Särndahl, E; Stendahl, O1
Parekh, AB1
Berman, DM; Gilman, AG; Kozasa, T1
Bourne, HR; Chi, P; Garcia, PD; Herzmark, P; Kingsley, C; Lichtarge, O; Onrust, R1
Delmas, P; Gola, M1
Berman, DM; Gilman, AG; Sprang, SR; Tesmer, JJ1
Ahmadian, MR; Kabsch, W; Lautwein, A; Scheffzek, K; Schmitz, F; Wiesmüller, L; Wittinghofer, A1
Díaz, JF; Engelborghs, Y; Sillen, A1
Andersson, T; Dimitrijevic, I; Eckerdal, J; Zheng, L1
Sprang, SR1
Bollag, G; Gilman, AG; Hart, MJ; Jiang, X; Kozasa, T; Singer, WD; Sternweis, PC; Sternweis, PM1
Bollag, G; Gilman, AG; Hart, MJ; Jiang, X; Kozasa, T; Roscoe, W; Singer, WD; Sternweis, PC1
Matalon, R; Warner, DR; Weinstein, LS; Weng, G; Yu, S1
Caplow, M; Shanks, J1
Zhang, B; Zheng, Y1
Eccleston, JF; Graham, DL; Lowe, PN1
Romanowski, R; Warner, DR; Weinstein, LS; Yu, S1
Warner, DR; Weinstein, LS1
Díaz, JF; Engelborghs, Y; Kuppens, S1
Geyer, M; Herrmann, C; Praefcke, GJ; Robert Kalbitzer, H; Schwemmle, M1
Coleman, DE; Sprang, SR1
Chung, CW; Eccleston, JF; Graham, DL; Lowe, PN1
Díaz, JF; Engelborghs, Y; Escalona, MM; Kuppens, S1
Fukamizu, A; Haga, T; Ishida, J; Kimura, S; Moroi, K; Nishiyama, M; Sekiya, S; Shibasaki, T; Usui, H; Zhou, J1
Hamm, HE; Skiba, NP; Thomas, TO1
Brown, FD; Donaldson, JG; Foroni, L; Hsu, VW; Jackson, TR; Miura, K; Nie, Z; Randazzo, PA; Sun, J1
Li, H; Wu, G; Yang, Z1
Brothers, GM; De Vries, L; Farquhar, MG; Fischer, T; Siderovski, DP; Strockbine, B; Tronchère, H1
Ahmadian, MR; Barbieri, JT; Buchwald, G; Pederson, KJ; Wittinghofer, A; Wolf, E; Würtele, M1
Quinton, PM; Reddy, MM; Sun, D1
Galán, JE; Stebbins, CE1
Behe, CI; De Vries, L; Gist Farquhar, M; Kimple, RJ; Morris, RA; Siderovski, DP; Tronchère, H1
Miller, HP; Panda, D; Wilson, L1
Aebi, U; Haener, M; Haller, O; Kochs, G1
Ashford, AE; Cole, L; Davies, D; Hyde, GJ1
Eccleston, JF; Gamblin, SJ; Graham, DL; Grime, GW; Lowe, PN; Marsh, M; Rittinger, K; Smerdon, SJ1
Brito, M; Guzmán, L; Hinrichs, MV; Olate, J; Romo, X; Soto, X1
Hamm, HE; Hubbell, WL; Medkova, M; Preininger, AM; Van Eps, N; Yu, NJ1
González, JM; Mingorance, J; Rivas, G; Tadros, M; Vélez, M; Vicente, M1
Cerione, RA; Pereira, R1
Jehl, M; Nayak, SK; Ross, EM; Tang, W; Tu, Y; Woodson, J1
Chardin, P; Franco, M; Klein, S; Luton, F1
Coon, JS; Focia, PJ; Freymann, DM; Gawronski-Salerno, J1
Arshavsky, VY; Blaesius, R; Fredericks, Z; Johnston, CA; Kuhlman, B; Lobanova, ES; Low, J; Ramer, JK; Shavkunov, AS; Siderovski, DP; Willard, FS1
Hwang, KY; Kim, EE; Ko, YG; Lee, WH; Nam, KH; Rhee, KH1
Cheng, HC; Gayler, KR; Gunawardana, D1
Frank, J; Gursky, R; Kjeldgaard, M; Nilsson, J; Nissen, P; Sengupta, J1
Gasper, R; Gotthardt, K; Meyer, S; Sirajuddin, M; Wittinghofer, A1
Acharya, S; Chappie, JS; Dyda, F; Leonard, M; Schmid, SL1
Ash, MR; Guss, JM; Jormakka, M; Maher, MJ1
Ataide, SF; Ban, N; Schmitz, N; Shan, SO; Shen, K; Voigts-Hoffmann, F1
Guo, X; Hu, J; Lou, Z; Qi, Y; Rao, Z; Yan, L; Yu, C; Zhao, J1

Reviews

2 review(s) available for fluorides and guanosine diphosphate

ArticleYear
Genetic analysis of hormone-sensitive adenylate cyclase.
    Advances in cyclic nucleotide research, 1980, Volume: 13

    Topics: Adenylyl Cyclases; Animals; Cell Line; Cholera Toxin; Cyclic AMP; Fluorides; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Hormones; Humans; Magnesium; Mice; Models, Biological; Receptors, Adrenergic, beta

1980
It takes two to tango: regulation of G proteins by dimerization.
    Nature reviews. Molecular cell biology, 2009, Volume: 10, Issue:6

    Topics: Aluminum Compounds; Animals; Binding Sites; Dimerization; Fluorides; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Humans; Models, Molecular; Plant Proteins; Protein Structure, Quaternary

2009

Other Studies

92 other study(ies) available for fluorides and guanosine diphosphate

ArticleYear
Guanosine 5'-O-(2-thiodiphosphate). An inhibitor of adenylate cyclase stimulation by guanine nucleotides and fluoride ions.
    The Journal of biological chemistry, 1979, Oct-10, Volume: 254, Issue:19

    Topics: Adenylyl Cyclases; Animals; Cell Membrane; Enzyme Activation; Erythrocyte Membrane; Fluorides; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Isoproterenol; Kinetics; Liver; Parotid Gland; Propranolol; Rats; Thionucleotides; Turkeys

1979
GTP-binding proteins inhibit cAMP activation of chloride channels in cystic fibrosis airway epithelial cells.
    Proceedings of the National Academy of Sciences of the United States of America, 1992, Nov-15, Volume: 89, Issue:22

    Topics: Aluminum; Aluminum Compounds; Cell Line; Cell Line, Transformed; Cells, Cultured; Chloride Channels; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelium; Fluorides; Fluorine; Genotype; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Humans; Ion Channels; Membrane Potentials; Membrane Proteins; Mutation; Pertussis Toxin; Respiratory Physiological Phenomena; Respiratory System; Thionucleotides; Virulence Factors, Bordetella

1992
Adenylate cyclase from Hirudo medicinalis segmental ganglia: modulation by physiological and non-physiological agents.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1992, Volume: 103, Issue:3

    Topics: Adenylyl Cyclases; Animals; Fluorides; Ganglia; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Leeches; Serotonin; Thionucleotides

1992
Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq.
    Science (New York, N.Y.), 1991, Feb-15, Volume: 251, Issue:4995

    Topics: Aluminum; Aluminum Compounds; Animals; Calcium; Cattle; Enzyme Activation; Fluorides; GTP-Binding Proteins; Guanosine Diphosphate; In Vitro Techniques; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases; Substrate Specificity

1991
Labeling of the beta gamma subunit complex of transducin with an environmentally sensitive cysteine reagent. Use of fluorescence spectroscopy to monitor transducin subunit interactions.
    The Journal of biological chemistry, 1991, Jun-15, Volume: 266, Issue:17

    Topics: Aluminum; Aluminum Compounds; Anilino Naphthalenesulfonates; Animals; Cattle; Cysteine; Fluorides; Fluorine; GTP Phosphohydrolases; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Kinetics; Macromolecular Substances; Rhodopsin; Rod Cell Outer Segment; Spectrometry, Fluorescence; Sulfhydryl Reagents; Transducin

1991
Involvement of GTP-binding proteins in actin polymerization in human neutrophils.
    Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:8

    Topics: Actins; Aluminum; Aluminum Compounds; Aminoquinolines; Calcium; Cytosol; Fluorescent Dyes; Fluorides; Fluorine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Humans; In Vitro Techniques; Kinetics; Macromolecular Substances; Neutrophils; Thionucleotides; Type C Phospholipases

1990
Synthesis of platelet-activating factor by endothelial cells. The role of G proteins.
    The Journal of biological chemistry, 1990, Sep-15, Volume: 265, Issue:26

    Topics: Aluminum; Aluminum Compounds; Animals; Biological Transport, Active; Calcium; Cattle; Cell Adhesion; Cells, Cultured; Endothelium, Vascular; Fluorides; Fluorine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Humans; Kinetics; Neutrophils; Platelet Activating Factor; Sodium Fluoride; Thionucleotides

1990
The epidermal growth factor receptor is coupled to a phospholipase A2-specific pertussis toxin-inhibitable guanine nucleotide-binding regulatory protein in cultured rat inner medullary collecting tubule cells.
    The Journal of biological chemistry, 1990, Mar-15, Volume: 265, Issue:8

    Topics: Adenosine Diphosphate Ribose; Aluminum; Aluminum Compounds; Animals; Calcium; Cells, Cultured; Dinoprostone; Epidermal Growth Factor; ErbB Receptors; Fluorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Kidney Medulla; Kidney Tubules; Kidney Tubules, Collecting; Kinetics; Pertussis Toxin; Phosphatidylinositols; Phospholipases; Phospholipases A; Phospholipases A2; Rats; Tetradecanoylphorbol Acetate; Thionucleotides; Virulence Factors, Bordetella

1990
A novel magnesium-dependent mechanism for the activation of transducin by fluoride.
    FEBS letters, 1990, Jul-30, Volume: 268, Issue:1

    Topics: Aluminum; Aluminum Compounds; Animals; Beryllium; Cattle; Enzyme Activation; Fluorides; Guanosine Diphosphate; Kinetics; Magnesium; Rod Cell Outer Segment; Spectrometry, Fluorescence; Transducin

1990
An estimate of the number of G regulator proteins activated per excited rhodopsin in living Limulus ventral photoreceptors.
    Proceedings of the National Academy of Sciences of the United States of America, 1989, Volume: 86, Issue:10

    Topics: Animals; Fluorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Horseshoe Crabs; Light; Photoreceptor Cells; Retinal Pigments; Rhodopsin; Thionucleotides; Time Factors; Vision, Ocular

1989
Mechanism of GTP hydrolysis in tubulin polymerization: characterization of the kinetic intermediate microtubule-GDP-Pi using phosphate analogues.
    Biochemistry, 1989, Feb-21, Volume: 28, Issue:4

    Topics: Animals; Beryllium; Brain; Fluorides; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Triphosphate; Hydrolysis; Kinetics; Macromolecular Substances; Mathematics; Microtubules; Models, Theoretical; Phosphates; Structure-Activity Relationship; Swine; Tubulin

1989
Characterization of the aluminum and beryllium fluoride species bound to F-actin and microtubules at the site of the gamma-phosphate of the nucleotide.
    The Journal of biological chemistry, 1989, Nov-15, Volume: 264, Issue:32

    Topics: Actins; Adenosine Diphosphate; Aluminum; Aluminum Compounds; Animals; Beryllium; Fluorides; Guanine Nucleotides; Guanosine Diphosphate; Microtubules; Muscles; Rabbits

1989
Fluoride complexes of aluminium or beryllium act on G-proteins as reversibly bound analogues of the gamma phosphate of GTP.
    The EMBO journal, 1987, Volume: 6, Issue:10

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Aluminum; Aluminum Compounds; Animals; Beryllium; Cattle; Fluorides; GTP-Binding Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Kinetics; Photoreceptor Cells; Protein Binding; Rod Cell Outer Segment

1987
The new positive inotrope sulmazole inhibits the function of guanine nucleotide regulatory proteins by affecting GTP turnover.
    Molecular pharmacology, 1988, Volume: 34, Issue:6

    Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclases; Adipose Tissue; Animals; Cardiotonic Agents; Cholera Toxin; Colforsin; Cyclic AMP; Fluorides; GTP-Binding Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Imidazoles; In Vitro Techniques; Isoproterenol; Male; Pertussis Toxin; Rats; Rats, Inbred Strains; Virulence Factors, Bordetella

1988
Pathway of phospholipase C activation initiated with platelet-derived growth factor is different from that initiated with vasopressin and bombesin.
    The Journal of biological chemistry, 1988, Sep-15, Volume: 263, Issue:26

    Topics: Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Bombesin; Calcium; Cell Membrane Permeability; Cells, Cultured; Chlorides; Enzyme Activation; Fluorides; Fluorine; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Platelet-Derived Growth Factor; Rats; Saponins; Sodium Fluoride; Thionucleotides; Type C Phospholipases; Vasopressins

1988
A mutation that prevents GTP-dependent activation of the alpha chain of Gs.
    Nature, 1988, Aug-25, Volume: 334, Issue:6184

    Topics: Adenosine Triphosphate; Adenylyl Cyclases; Aluminum; Aluminum Compounds; Animals; Binding Sites; Cell Membrane; DNA; Fluorides; GTP-Binding Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Lymphoma; Magnesium; Mice; Mutation; Protein Conformation; Trypsin; Tumor Cells, Cultured

1988
Fluoroaluminates activate transducin-GDP by mimicking the gamma-phosphate of GTP in its binding site.
    FEBS letters, 1985, Oct-28, Volume: 191, Issue:2

    Topics: Aluminum; Aluminum Compounds; Animals; Binding Sites; Cattle; Fluorides; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Triphosphate; Light; Membrane Proteins; Phosphates; Photoreceptor Cells; Rod Cell Outer Segment; Sodium Fluoride; Thionucleotides; Transducin

1985
Fluoride stimulation of adenylate cyclase is dependent on the guanine nucleotide regulatory protein.
    The Journal of biological chemistry, 1980, Feb-10, Volume: 255, Issue:3

    Topics: Adenylyl Cyclases; Animals; Enzyme Activation; Erythrocyte Membrane; Erythrocytes; Fluorides; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Monophosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Isoproterenol; Kinetics; Membrane Proteins; Temperature; Turkeys

1980
Structure of the turkey erythrocyte adenylate cyclase system.
    Proceedings of the National Academy of Sciences of the United States of America, 1981, Volume: 78, Issue:2

    Topics: Adenylyl Cyclases; Animals; Benzyl Alcohols; Erythrocytes; Fluorides; Guanosine Diphosphate; Guanylyl Imidodiphosphate; Isoproterenol; Kinetics; Molecular Weight; Pindolol; Protein Binding; Receptors, Adrenergic, beta; Turkeys

1981
Interactions of fluoride and guanine nucleotides with thyroid adenylate cyclase.
    Biochimica et biophysica acta, 1982, Feb-18, Volume: 701, Issue:2

    Topics: Adenylate Kinase; Adenylyl Imidodiphosphate; Animals; Cattle; Enzyme Activation; Fluorides; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Kinetics; Phosphotransferases; Sodium Fluoride; Thionucleotides; Thyroid Gland

1982
Hysteretic activation of adenylyl cyclases. I. Effect of Mg ion on the rate of activation by guanine nucleotides and fluoride.
    The Journal of biological chemistry, 1981, Nov-10, Volume: 256, Issue:21

    Topics: Adenylyl Cyclases; Animals; Cell Membrane; Enzyme Activation; Fluorides; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Kinetics; Liver; Magnesium; Rats; Sodium Fluoride

1981
Aluminum fluoride activation of bovine transducin induces two distinct conformational changes in the alpha subunit.
    Biochemistry, 1994, Aug-23, Volume: 33, Issue:33

    Topics: Aluminum Compounds; Animals; Cattle; Energy Transfer; Eosine Yellowish-(YS); Fluoresceins; Fluorescent Dyes; Fluorides; Guanosine Diphosphate; Kinetics; Macromolecular Substances; Protein Conformation; Spectrometry, Fluorescence; Transducin

1994
Mg2+-dependent phosphatase as an inhibitory mediator of the nonselective cation current induced by aluminum fluoride in guinea-pig chromaffin cells.
    Brain research, 1995, Jul-31, Volume: 687, Issue:1-2

    Topics: Aluminum Compounds; Animals; Cations; Chromaffin System; Fluorides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Guinea Pigs; Ion Channels; Magnesium; Muscarine; Muscarinic Agonists; Patch-Clamp Techniques; Phosphoprotein Phosphatases; Protein Phosphatase 2C

1995
Differential scanning calorimetric study of the complexes of myosin subfragment 1 with nucleoside diphosphates and vanadate or beryllium fluoride.
    Biochemistry, 1995, Aug-01, Volume: 34, Issue:30

    Topics: Adenosine Diphosphate; Beryllium; Calorimetry, Differential Scanning; Cytidine Diphosphate; Fluorides; Guanosine Diphosphate; Inosine Diphosphate; Myosin Subfragments; Nucleotides; Protein Conformation; Thermodynamics; Uridine Diphosphate; Vanadates

1995
ATP causes release of intracellular Ca2+ via the phospholipase C beta/IP3 pathway in astrocytes from the dorsal spinal cord.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995, Volume: 15, Issue:4

    Topics: Adenosine Triphosphate; Aluminum Compounds; Animals; Astrocytes; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium-Transporting ATPases; Cells, Cultured; Egtazic Acid; Estrenes; Fetus; Fluorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Heparin; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Isoenzymes; Patch-Clamp Techniques; Pyrrolidinones; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Spinal Cord; Terpenes; Thapsigargin; Thionucleotides; Time Factors; Type C Phospholipases

1995
Modification of frequency augmentation-potentiation by GTP gamma S in the frog neuromuscular junction.
    Cell biochemistry and function, 1995, Volume: 13, Issue:2

    Topics: Action Potentials; Aluminum Compounds; Animals; Cell Line; Fluorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Neuromuscular Junction; Ranidae; Thionucleotides

1995
Role of G proteins in shear stress-mediated nitric oxide production by endothelial cells.
    The American journal of physiology, 1994, Volume: 267, Issue:3 Pt 1

    Topics: Aluminum Compounds; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Fluorides; GTP-Binding Proteins; Guanosine Diphosphate; Humans; Nitric Oxide; Osmolar Concentration; Pertussis Toxin; Stress, Mechanical; Thionucleotides; Virulence Factors, Bordetella

1994
Requirement for intramolecular domain interaction in activation of G protein alpha subunit by aluminum fluoride and GDP but not by GTP gamma S.
    The Journal of biological chemistry, 1994, Nov-25, Volume: 269, Issue:47

    Topics: Aluminum Compounds; Amino Acid Sequence; Fluorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Molecular Sequence Data

1994
GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4.
    Nature, 1994, Nov-17, Volume: 372, Issue:6503

    Topics: Aluminum Compounds; Animals; Cattle; Computer Graphics; Crystallography, X-Ray; Fluorides; GTP Phosphohydrolases; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Hydrolysis; Mutagenesis; Protein Conformation; Transducin; Water

1994
Fluoride activates G protein-dependent and -independent pathways in dispersed intestinal smooth muscle cells.
    Biochemical and biophysical research communications, 1994, Aug-15, Volume: 202, Issue:3

    Topics: Animals; Biological Transport; Calcium; Cell Membrane Permeability; Cells, Cultured; Diglycerides; Fluorides; GTP-Binding Proteins; Guanosine Diphosphate; Guinea Pigs; Inositol Phosphates; Intestines; Muscle Contraction; Muscle, Smooth; Protein Kinase C; Thionucleotides

1994
Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis.
    Science (New York, N.Y.), 1994, Sep-02, Volume: 265, Issue:5177

    Topics: Aluminum Compounds; Arginine; Binding Sites; Catalysis; Computer Graphics; Crystallography, X-Ray; Fluorides; Glutamine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Helix-Loop-Helix Motifs; Hydrogen Bonding; Hydrolysis; Models, Molecular; Protein Conformation; Protein Structure, Secondary

1994
G proteins activate ATP-sensitive K+ channels by antagonizing ATP-dependent gating.
    Neuron, 1994, Volume: 12, Issue:4

    Topics: Acetylcholine; Adenosine; Adenosine Triphosphate; Aluminum Compounds; Animals; Fluorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Guinea Pigs; Inosine Diphosphate; Ion Channel Gating; Potassium Channels; Thionucleotides; Uridine Diphosphate

1994
Evidence that v-Src-induced phospholipase D activity is mediated by a G protein.
    Molecular and cellular biology, 1994, Volume: 14, Issue:6

    Topics: 3T3 Cells; Adenine Nucleotides; Aluminum Compounds; Animals; Arachidonic Acid; Avian Sarcoma Viruses; Benzoquinones; Cell Line, Transformed; Cholera Toxin; Enzyme Induction; Fluorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Kinetics; Lactams, Macrocyclic; Mice; Mice, Inbred BALB C; Myristic Acid; Myristic Acids; Oncogene Protein pp60(v-src); Phosphatidylcholines; Phospholipase D; Protein-Tyrosine Kinases; Quinones; Rifabutin; Tetradecanoylphorbol Acetate; Thionucleotides; Virulence Factors, Bordetella

1994
Tryptophan W207 in transducin T alpha is the fluorescence sensor of the G protein activation switch and is involved in the effector binding.
    The EMBO journal, 1993, Volume: 12, Issue:11

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Aluminum Compounds; Amino Acid Sequence; Animals; Baculoviridae; DNA Mutational Analysis; Enzyme Activation; Fluorescence; Fluorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Models, Molecular; Molecular Sequence Data; Moths; Protein Conformation; Recombinant Proteins; Rod Cell Outer Segment; Sequence Homology, Amino Acid; Signal Transduction; Transducin; Tryptophan

1993
Activated release of membrane-anchored TGF-alpha in the absence of cytosol.
    The Journal of cell biology, 1993, Volume: 122, Issue:1

    Topics: Aluminum; Aluminum Compounds; Animals; Cell Membrane; Cell Membrane Permeability; CHO Cells; Cricetinae; Fluorides; Fluorine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Kinetics; Protein Kinase C; Protein Precursors; Protein Processing, Post-Translational; Rats; Recombinant Proteins; Tetradecanoylphorbol Acetate; Thionucleotides; Transfection; Transforming Growth Factor alpha

1993
The mechanism of aluminum-independent G-protein activation by fluoride and magnesium. 31P NMR spectroscopy and fluorescence kinetic studies.
    The Journal of biological chemistry, 1993, Feb-05, Volume: 268, Issue:4

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adenylyl Cyclases; Aluminum; Animals; Cattle; Enzyme Activation; Fluorides; GTP-Binding Proteins; Guanosine Diphosphate; In Vitro Techniques; Kinetics; Magnesium; Magnetic Resonance Spectroscopy; Recombinant Proteins; Spectrometry, Fluorescence; Transducin; Tryptophan

1993
Multiple GTP-binding proteins participate in clathrin-coated vesicle-mediated endocytosis.
    The Journal of cell biology, 1993, Volume: 120, Issue:1

    Topics: Aluminum; Aluminum Compounds; Amino Acid Sequence; Coated Pits, Cell-Membrane; Endocytosis; Fluorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Humans; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Molecular Sequence Data; Peptides; Receptors, Transferrin; Thionucleotides; Tumor Cells, Cultured; Wasp Venoms

1993
A functional role for GTP-binding proteins in synaptic vesicle cycling.
    Science (New York, N.Y.), 1993, Feb-19, Volume: 259, Issue:5098

    Topics: Aluminum; Aluminum Compounds; Animals; Calcium; Decapodiformes; Fluorides; Fluorine; Ganglia; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; In Vitro Techniques; Kinetics; Models, Neurological; Nerve Endings; Signal Transduction; Synaptic Vesicles; Thionucleotides; Time Factors

1993
Thermodynamics of tubulin polymerization into zinc sheets: assembly is not regulated by GTP hydrolysis.
    Biochemistry, 1993, Apr-06, Volume: 32, Issue:13

    Topics: Aluminum; Aluminum Compounds; Animals; Beryllium; Brain; Colchicine; Fluorides; Guanosine Diphosphate; Guanosine Triphosphate; Kinetics; Microscopy, Electron; Polymers; Rats; Subtilisins; Swine; Temperature; Thermodynamics; Tubulin; Zinc

1993
Intracellular Cl- modulates Ca2+-induced exocytosis from rat melanotrophs through GTP-binding proteins.
    Pflugers Archiv : European journal of physiology, 1995, Volume: 431, Issue:1

    Topics: Aluminum Compounds; Animals; Calcium; Cells, Cultured; Chlorides; Cytosol; Electrophysiology; Exocytosis; Fluorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Melanocytes; Patch-Clamp Techniques; Pertussis Toxin; Rats; Thionucleotides; Virulence Factors, Bordetella

1995
Formation of a transition-state analog of the Ras GTPase reaction by Ras-GDP, tetrafluoroaluminate, and GTPase-activating proteins.
    Science (New York, N.Y.), 1996, Jul-05, Volume: 273, Issue:5271

    Topics: Aluminum Compounds; Amino Acid Sequence; Fluorides; GTP Phosphohydrolases; GTPase-Activating Proteins; Guanosine Diphosphate; Molecular Sequence Data; Mutagenesis; Neurofibromin 1; Proteins; ras GTPase-Activating Proteins; ras Proteins; Spectrometry, Fluorescence

1996
Direct or C5a-induced activation of heterotrimeric Gi2 proteins in human neutrophils is associated with interaction between formyl peptide receptors and the cytoskeleton.
    The Journal of biological chemistry, 1996, Jun-21, Volume: 271, Issue:25

    Topics: Aluminum Compounds; Complement C5a; Cytoskeleton; Fluorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Humans; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Receptors, Formyl Peptide; Receptors, Immunologic; Receptors, Peptide; Thionucleotides

1996
Nonhydrolyzable analogues of GTP activate a new Na+ current in a rat mast cell line.
    The Journal of biological chemistry, 1996, Sep-20, Volume: 271, Issue:38

    Topics: Animals; Biological Transport; Cell Membrane Permeability; Cell Polarity; Electric Conductivity; Fluorides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Hydrolysis; Mast Cells; Patch-Clamp Techniques; Rats; Second Messenger Systems; Sodium; Sodium Channels; Thionucleotides; Tumor Cells, Cultured

1996
The GTPase-activating protein RGS4 stabilizes the transition state for nucleotide hydrolysis.
    The Journal of biological chemistry, 1996, Nov-01, Volume: 271, Issue:44

    Topics: Aluminum Compounds; Animals; Fluorides; GTP Phosphohydrolases; GTP-Binding Proteins; GTPase-Activating Proteins; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Hydrolysis; Kinetics; Mammals; Proteins; Recombinant Proteins; RGS Proteins

1996
Receptor and betagamma binding sites in the alpha subunit of the retinal G protein transducin.
    Science (New York, N.Y.), 1997, Jan-17, Volume: 275, Issue:5298

    Topics: Aluminum Compounds; Animals; Binding Sites; COS Cells; Fluorides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Models, Molecular; Mutation; Phenotype; Protein Conformation; Retinaldehyde; Rhodopsin; Rod Cell Outer Segment; Transducin

1997
Exotoxin-insensitive G proteins mediate synaptically evoked muscarinic sodium current in rabbit sympathetic neurones.
    The Journal of physiology, 1997, Feb-01, Volume: 498 ( Pt 3)

    Topics: Animals; Cells, Cultured; Cholera Toxin; Electrophysiology; Exotoxins; Fluorides; Ganglia, Sympathetic; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Membrane Potentials; Muscarinic Agonists; Patch-Clamp Techniques; Pertussis Toxin; Rabbits; Receptors, Muscarinic; Sodium Channels; Sympathetic Nervous System; Synapses; Thionucleotides; Virulence Factors, Bordetella

1997
Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis.
    Cell, 1997, Apr-18, Volume: 89, Issue:2

    Topics: Aluminum Compounds; Amino Acid Sequence; Animals; Binding Sites; Crystallography, X-Ray; Fluorides; GTP Phosphohydrolases; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine Diphosphate; Guanosine Triphosphate; Hydrolysis; Magnesium; Models, Molecular; Molecular Sequence Data; Protein Binding; Protein Conformation; Proteins; Rats; RGS Proteins

1997
The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants.
    Science (New York, N.Y.), 1997, Jul-18, Volume: 277, Issue:5324

    Topics: Aluminum Compounds; Amino Acid Sequence; Binding Sites; Catalysis; Cell Transformation, Neoplastic; Crystallography, X-Ray; Enzyme Activation; Fluorides; GTP Phosphohydrolases; GTP-Binding Proteins; GTPase-Activating Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Humans; Models, Molecular; Molecular Sequence Data; Mutation; Protein Conformation; Protein Structure, Secondary; Proteins; ras GTPase-Activating Proteins; ras Proteins; Signal Transduction

1997
Equilibrium and kinetic study of the conformational transition toward the active state of p21Ha-ras, induced by the binding of BeF3- to the GDP-bound state, in the absence of GTPase-activating proteins.
    The Journal of biological chemistry, 1997, Sep-12, Volume: 272, Issue:37

    Topics: Anions; Beryllium; Flow Injection Analysis; Fluorides; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Triphosphate; Kinetics; Models, Chemical; Mutation; Phosphates; Protein Conformation; Proto-Oncogene Proteins p21(ras); Recombinant Proteins; Spectrometry, Fluorescence

1997
Chemotactic peptide-induced activation of Ras in human neutrophils is associated with inhibition of p120-GAP activity.
    The Journal of biological chemistry, 1997, Sep-12, Volume: 272, Issue:37

    Topics: Adaptor Proteins, Signal Transducing; Calcium; Fluorides; GRB2 Adaptor Protein; GTP-Binding Protein alpha Subunits, Gi-Go; GTPase-Activating Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Humans; Membrane Proteins; N-Formylmethionine Leucyl-Phenylalanine; Neurofibromin 1; Neutrophils; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Precipitin Tests; Protein-Tyrosine Kinases; Proteins; ras GTPase-Activating Proteins; ras Proteins; Signal Transduction; Son of Sevenless Proteins; Type C Phospholipases; Virulence Factors, Bordetella

1997
GAP into the breach.
    Science (New York, N.Y.), 1997, Jul-18, Volume: 277, Issue:5324

    Topics: Aluminum Compounds; Binding Sites; Catalysis; Crystallography, X-Ray; Fluorides; GTP Phosphohydrolases; GTP-Binding Proteins; GTPase-Activating Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Hydrolysis; Models, Molecular; Protein Conformation; Protein Structure, Secondary; Proteins; ras GTPase-Activating Proteins; ras Proteins; RGS Proteins

1997
p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13.
    Science (New York, N.Y.), 1998, Jun-26, Volume: 280, Issue:5372

    Topics: Aluminum Compounds; Amino Acid Sequence; Animals; Fluorides; GTP Phosphohydrolases; GTP-Binding Protein alpha Subunits, G12-G13; GTP-Binding Proteins; Guanine Nucleotide Exchange Factors; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Humans; Hydrolysis; Molecular Sequence Data; Proteins; Recombinant Fusion Proteins; Sequence Alignment; Signal Transduction

1998
Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13.
    Science (New York, N.Y.), 1998, Jun-26, Volume: 280, Issue:5372

    Topics: Aluminum Compounds; Animals; COS Cells; Fluorides; GTP Phosphohydrolases; GTP-Binding Protein alpha Subunits, G12-G13; GTP-Binding Proteins; Guanine Nucleotide Exchange Factors; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Proteins; Recombinant Fusion Proteins; Recombinant Proteins; Signal Transduction

1998
A novel mutation in the switch 3 region of Gsalpha in a patient with Albright hereditary osteodystrophy impairs GDP binding and receptor activation.
    The Journal of biological chemistry, 1998, Sep-11, Volume: 273, Issue:37

    Topics: Adenylyl Cyclases; Adult; Alanine; Aluminum Compounds; Amino Acid Sequence; Arginine; Base Sequence; Binding Sites; Cloning, Molecular; Erythrocyte Membrane; Escherichia coli; Exons; Female; Fibrous Dysplasia, Polyostotic; Fluorides; GTP-Binding Protein alpha Subunits, Gs; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Humans; Male; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Polymerase Chain Reaction; Protein Biosynthesis; Protein Structure, Secondary; Receptors, Cell Surface; Recombinant Proteins; RNA, Messenger; Transcription, Genetic; Tryptophan

1998
Microtubule dynamic instability does not result from stabilization of microtubules by tubulin-GDP-Pi subunits.
    Biochemistry, 1998, Sep-15, Volume: 37, Issue:37

    Topics: Animals; Beryllium; Cattle; Fluorides; Guanosine Diphosphate; Microtubules; Models, Biological; Phosphates; Protein Binding; Protein Processing, Post-Translational; Tubulin

1998
Negative regulation of Rho family GTPases Cdc42 and Rac2 by homodimer formation.
    The Journal of biological chemistry, 1998, Oct-02, Volume: 273, Issue:40

    Topics: Aluminum Compounds; cdc42 GTP-Binding Protein, Saccharomyces cerevisiae; Cell Cycle Proteins; Dimerization; Fluorides; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Humans; ortho-Aminobenzoates; rac GTP-Binding Proteins; ras Proteins; rhoA GTP-Binding Protein; Sequence Alignment; Signal Transduction; Spectrometry, Fluorescence

1998
The conserved arginine in rho-GTPase-activating protein is essential for efficient catalysis but not for complex formation with Rho.GDP and aluminum fluoride.
    Biochemistry, 1999, Jan-19, Volume: 38, Issue:3

    Topics: Alanine; Aluminum Compounds; Arginine; Catalysis; Conserved Sequence; Fluorides; GTP Phosphohydrolases; GTP-Binding Proteins; GTPase-Activating Proteins; Guanosine Diphosphate; Guanylyl Imidodiphosphate; Humans; Lysine; Macromolecular Substances; ortho-Aminobenzoates; Protein Binding; Rho Factor

1999
Mutagenesis of the conserved residue Glu259 of Gsalpha demonstrates the importance of interactions between switches 2 and 3 for activation.
    The Journal of biological chemistry, 1999, Feb-19, Volume: 274, Issue:8

    Topics: Aluminum Compounds; Animals; Base Sequence; Cattle; Conserved Sequence; DNA Primers; Fluorides; Glutamic Acid; GTP-Binding Protein alpha Subunits, Gs; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Kinetics; Magnesium; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Recombinant Proteins

1999
A mutation in the heterotrimeric stimulatory guanine nucleotide binding protein alpha-subunit with impaired receptor-mediated activation because of elevated GTPase activity.
    Proceedings of the National Academy of Sciences of the United States of America, 1999, Apr-13, Volume: 96, Issue:8

    Topics: Adenylyl Cyclases; Aluminum Compounds; Amino Acid Substitution; Animals; Arginine; Cattle; Cloning, Molecular; Escherichia coli; Fibrous Dysplasia, Polyostotic; Fluorides; Glutamine; GTP Phosphohydrolases; GTP-Binding Protein alpha Subunits, Gs; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Humans; Isoproterenol; Kinetics; Macromolecular Substances; Mutagenesis, Site-Directed; Polymerase Chain Reaction; Protein Structure, Secondary; Recombinant Proteins

1999
Characterization of the hinges of the effector loop in the reaction pathway of the activation of ras-proteins. Kinetics of binding of beryllium trifluoride to V29G and I36G mutants of Ha-ras-p21.
    Protein science : a publication of the Protein Society, 1999, Volume: 8, Issue:9

    Topics: Beryllium; Fluorides; Glycine; Guanosine Diphosphate; Humans; Isoleucine; Kinetics; Point Mutation; Protein Binding; Protein Conformation; Proto-Oncogene Proteins p21(ras); Thermodynamics; Valine

1999
Nucleotide-binding characteristics of human guanylate-binding protein 1 (hGBP1) and identification of the third GTP-binding motif.
    Journal of molecular biology, 1999, Sep-17, Volume: 292, Issue:2

    Topics: Aluminum Compounds; Binding Sites; Binding, Competitive; Calorimetry; DNA-Binding Proteins; Fluorides; Fluorometry; GTP-Binding Proteins; Guanosine Diphosphate; Guanosine Monophosphate; Guanosine Triphosphate; Humans; Kinetics; Magnetic Resonance Spectroscopy; Mutation; Recombinant Proteins; Thermodynamics

1999
Reaction dynamics of G-protein catalyzed hydrolysis of GTP as viewed by X-ray crystallographic snapshots of Gi alpha 1.
    Methods in enzymology, 1999, Volume: 308

    Topics: Aluminum Compounds; Binding Sites; Crystallography, X-Ray; Fluorides; GTP Phosphohydrolases; GTP-Binding Proteins; GTPase-Activating Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Hydrogen Bonding; Models, Molecular; Protein Binding; Protein Conformation; Proteins; Signal Transduction

1999
Magnesium fluoride-dependent binding of small G proteins to their GTPase-activating proteins.
    Biochemistry, 1999, Nov-09, Volume: 38, Issue:45

    Topics: Aluminum; Fluorides; GTPase-Activating Proteins; Guanosine Diphosphate; Kinetics; Magnesium Chloride; Magnesium Compounds; Magnetic Resonance Spectroscopy; Monomeric GTP-Binding Proteins; Neurofibromin 1; Protein Binding; Protein Conformation; Proteins; ras Proteins; rhoB GTP-Binding Protein; Sodium Fluoride; X-Ray Diffraction

1999
Role of the switch II region in the conformational transition of activation of Ha-ras-p21.
    Protein science : a publication of the Protein Society, 2000, Volume: 9, Issue:2

    Topics: Beryllium; Binding Sites; Catalytic Domain; Fluorides; Guanosine Diphosphate; Humans; In Vitro Techniques; Kinetics; Mutagenesis, Site-Directed; Protein Conformation; Proto-Oncogene Proteins p21(ras); Recombinant Proteins; Thermodynamics

2000
RGS domain in the amino-terminus of G protein-coupled receptor kinase 2 inhibits Gq-mediated signaling.
    International journal of molecular medicine, 2000, Volume: 5, Issue:4

    Topics: Aluminum Compounds; Angiotensin II; beta-Adrenergic Receptor Kinases; Calcium; Cell Line; Cyclic AMP-Dependent Protein Kinases; Endothelin-1; Fluorides; Fura-2; GTP-Binding Protein Regulators; GTP-Binding Proteins; Guanosine Diphosphate; Humans; Plasmids; Signal Transduction; Transfection

2000
G alpha t/G alpha i1 chimeras used to define structural basis of specific functions of G alpha t.
    Methods in enzymology, 2000, Volume: 315

    Topics: Aluminum Compounds; Amino Acid Substitution; Cloning, Molecular; Escherichia coli; Fluorides; GTP Phosphohydrolases; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Kinetics; Models, Molecular; Polymerase Chain Reaction; Protein Conformation; Protein Structure, Secondary; Recombinant Fusion Proteins; Restriction Mapping; Transducin

2000
ACAPs are arf6 GTPase-activating proteins that function in the cell periphery.
    The Journal of cell biology, 2000, Oct-30, Volume: 151, Issue:3

    Topics: 3T3 Cells; Actins; ADP-Ribosylation Factor 6; ADP-Ribosylation Factors; Aluminum Compounds; Amino Acid Sequence; Amino Acid Substitution; Animals; Arginine; Carrier Proteins; Cell Membrane; Cell Surface Extensions; Conserved Sequence; Cytoplasm; Cytoskeleton; Fluorides; GTPase-Activating Proteins; Guanosine Diphosphate; HeLa Cells; Humans; Mice; Molecular Sequence Data; Multigene Family; Phosphatidic Acids; Phosphatidylinositol 4,5-Diphosphate; Platelet-Derived Growth Factor; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity

2000
Arabidopsis RopGAPs are a novel family of rho GTPase-activating proteins that require the Cdc42/Rac-interactive binding motif for rop-specific GTPase stimulation.
    Plant physiology, 2000, Volume: 124, Issue:4

    Topics: Aluminum Compounds; Arabidopsis; Binding Sites; Binding, Competitive; cdc42 GTP-Binding Protein; DNA, Complementary; Fluorides; GTPase-Activating Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Mutation; Protein Binding; Sequence Alignment; Sequence Analysis, DNA; Sequence Deletion

2000
Activator of G protein signaling 3 is a guanine dissociation inhibitor for Galpha i subunits.
    Proceedings of the National Academy of Sciences of the United States of America, 2000, Dec-19, Volume: 97, Issue:26

    Topics: Aluminum Compounds; Amino Acid Motifs; Amino Acid Sequence; Animals; Cell Fractionation; Fluorides; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Proteins; Guanine; Guanine Nucleotide Dissociation Inhibitors; Guanosine Diphosphate; Heterotrimeric GTP-Binding Proteins; Molecular Sequence Data; Rats; Tissue Distribution

2000
How the Pseudomonas aeruginosa ExoS toxin downregulates Rac.
    Nature structural biology, 2001, Volume: 8, Issue:1

    Topics: Aluminum Compounds; Amino Acid Sequence; Bacterial Toxins; Binding Sites; Catalysis; Crystallography, X-Ray; Down-Regulation; Fluorides; GTPase-Activating Proteins; Guanosine Diphosphate; Histidine Kinase; Models, Molecular; Molecular Sequence Data; Protein Binding; Protein Folding; Protein Kinases; Protein Structure, Secondary; Protein Structure, Tertiary; Pseudomonas aeruginosa; rac GTP-Binding Proteins; Sequence Alignment; Structure-Activity Relationship

2001
Apical heterotrimeric g-proteins activate CFTR in the native sweat duct.
    The Journal of membrane biology, 2001, Jan-01, Volume: 179, Issue:1

    Topics: Adenosine Triphosphate; Adult; Aluminum Compounds; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Fluorides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Heterotrimeric GTP-Binding Proteins; Humans; Immunohistochemistry; In Vitro Techniques; Male; Mutation; Sodium Channels; Sodium-Potassium-Exchanging ATPase; Sweat Glands

2001
Modulation of host signaling by a bacterial mimic: structure of the Salmonella effector SptP bound to Rac1.
    Molecular cell, 2000, Volume: 6, Issue:6

    Topics: Aluminum Compounds; Amino Acid Sequence; Amino Acid Substitution; Bacterial Proteins; Binding Sites; cdc42 GTP-Binding Protein; Crystallography, X-Ray; Dimerization; Evolution, Molecular; Fluorides; GTPase-Activating Proteins; Guanosine Diphosphate; Macromolecular Substances; Models, Molecular; Molecular Sequence Data; Mutation; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Tyrosine Phosphatases; rac1 GTP-Binding Protein; Recombinant Fusion Proteins; Salmonella typhimurium; Sequence Alignment; Signal Transduction

2000
RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity.
    The Journal of biological chemistry, 2001, Aug-03, Volume: 276, Issue:31

    Topics: Aluminum Compounds; Amino Acid Sequence; Amino Acid Substitution; Animals; Binding Sites; Biosensing Techniques; Cloning, Molecular; Escherichia coli; Fluorides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Heterotrimeric GTP-Binding Proteins; Kinetics; Models, Biological; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligopeptides; Open Reading Frames; Rats; Recombinant Proteins; RGS Proteins; Signal Transduction; Surface Plasmon Resonance

2001
Determination of the size and chemical nature of the stabilizing "cap" at microtubule ends using modulators of polymerization dynamics.
    Biochemistry, 2002, Feb-05, Volume: 41, Issue:5

    Topics: Aluminum Compounds; Animals; Beryllium; Binding Sites; Brain Chemistry; Cattle; Fluorides; Guanosine Diphosphate; Guanosine Triphosphate; Male; Microscopy, Video; Microtubules; Phosphates; Phosphorus Radioisotopes; Polymers; Sea Urchins; Spermatozoa; Thermodynamics; Tubulin

2002
Self-assembly of human MxA GTPase into highly ordered dynamin-like oligomers.
    The Journal of biological chemistry, 2002, Apr-19, Volume: 277, Issue:16

    Topics: Aluminum Compounds; Dimerization; Dynamins; Escherichia coli; Fluorides; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Humans; Microscopy, Electron; Myxovirus Resistance Proteins; Protein Binding; Protein Conformation; Proteins; Recombinant Proteins; Salts

2002
Regulators of GTP-binding proteins cause morphological changes in the vacuole system of the filamentous fungus, Pisolithus tinctorius.
    Cell motility and the cytoskeleton, 2002, Volume: 51, Issue:3

    Topics: Aluminum Compounds; Basidiomycota; Brefeldin A; Cytoskeleton; Fluorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Hyphae; Protein Synthesis Inhibitors; Thionucleotides; Transport Vesicles; Vacuoles

2002
MgF(3)(-) as a transition state analog of phosphoryl transfer.
    Chemistry & biology, 2002, Volume: 9, Issue:3

    Topics: Aluminum Compounds; Fluorides; Guanosine Diphosphate; Magnesium Compounds; Models, Molecular; Phosphorus; rho GTP-Binding Proteins; Spectrometry, X-Ray Emission

2002
S111N mutation in the helical domain of human Gs(alpha) reduces its GDP/GTP exchange rate.
    Journal of cellular biochemistry, 2002, Volume: 85, Issue:3

    Topics: Adenylyl Cyclases; Aluminum Compounds; Amino Acid Substitution; Asparagine; Fluorides; GTP-Binding Protein alpha Subunits, Gs; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Humans; Models, Molecular; Point Mutation; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Receptors, Cell Surface; Serine; Trypsin

2002
The myristoylated amino terminus of Galpha(i)(1) plays a critical role in the structure and function of Galpha(i)(1) subunits in solution.
    Biochemistry, 2003, Jul-08, Volume: 42, Issue:26

    Topics: Aluminum Compounds; Cysteine; DNA Primers; Electron Spin Resonance Spectroscopy; Electrophoresis, Polyacrylamide Gel; Fluorescent Dyes; Fluorides; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Humans; Models, Molecular; Mutagenesis, Site-Directed; Myristic Acid; Protein Binding; Protein Conformation; Spin Labels; Structure-Activity Relationship; Sulfhydryl Compounds

2003
Visualization of single Escherichia coli FtsZ filament dynamics with atomic force microscopy.
    The Journal of biological chemistry, 2005, May-27, Volume: 280, Issue:21

    Topics: Adsorption; Aluminum Compounds; Aluminum Silicates; Chemical Phenomena; Chemistry, Physical; Escherichia coli; Escherichia coli Proteins; Fluorides; Guanosine Diphosphate; Guanosine Triphosphate; Hydrogen-Ion Concentration; Microscopy, Atomic Force; Polymers; Solutions

2005
A switch 3 point mutation in the alpha subunit of transducin yields a unique dominant-negative inhibitor.
    The Journal of biological chemistry, 2005, Oct-21, Volume: 280, Issue:42

    Topics: Aluminum Compounds; Animals; Arginine; Catalysis; Cattle; Chromatography, High Pressure Liquid; Cyclic GMP; Dose-Response Relationship, Drug; Fluorides; Genes, Dominant; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Models, Biological; Models, Molecular; Mutation; Nucleotides; Point Mutation; Protein Conformation; Recombinant Fusion Proteins; Recombinant Proteins; Retina; Rhodopsin; Signal Transduction; Spectrometry, Fluorescence; Time Factors; Transducin; Trypsin

2005
Gbetagamma inhibits Galpha GTPase-activating proteins by inhibition of Galpha-GTP binding during stimulation by receptor.
    The Journal of biological chemistry, 2006, Feb-24, Volume: 281, Issue:8

    Topics: Aluminum Compounds; Animals; Bacterial Proteins; Binding Sites; Catalysis; Cell Line; Escherichia coli; Eye Proteins; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Fluorides; Green Fluorescent Proteins; GTP Phosphohydrolases; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein beta Subunits; GTP-Binding Protein gamma Subunits; GTP-Binding Protein Regulators; GTPase-Activating Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Hydrolysis; Inhibitory Concentration 50; Insecta; Kinetics; Luminescent Proteins; Mutation; Phosphoproteins; Protein Binding; RGS Proteins; Spectrometry, Fluorescence; Type C Phospholipases

2006
Role of the Arf6 GDP/GTP cycle and Arf6 GTPase-activating proteins in actin remodeling and intracellular transport.
    The Journal of biological chemistry, 2006, May-05, Volume: 281, Issue:18

    Topics: Actins; ADP-Ribosylation Factor 6; ADP-Ribosylation Factors; Aluminum Compounds; Animals; Biological Transport; Cell Line; Cricetinae; Cytoskeleton; Fluorides; GTPase-Activating Proteins; Guanosine Diphosphate; HeLa Cells; Humans; Mutation; Phospholipids; Protein Binding; Recombinant Proteins

2006
Structure of a GDP:AlF4 complex of the SRP GTPases Ffh and FtsY, and identification of a peripheral nucleotide interaction site.
    Journal of molecular biology, 2006, Jul-14, Volume: 360, Issue:3

    Topics: Aluminum Compounds; Bacterial Proteins; Binding Sites; Crystallography, X-Ray; Dimerization; Fluorides; Fluorometry; GTP Phosphohydrolases; Guanosine Diphosphate; Guanosine Triphosphate; Magnesium; Models, Molecular; Molecular Conformation; Protein Binding; Receptors, Cytoplasmic and Nuclear; RNA, Bacterial; Signal Recognition Particle; Thermus

2006
Minimal determinants for binding activated G alpha from the structure of a G alpha(i1)-peptide dimer.
    Biochemistry, 2006, Sep-26, Volume: 45, Issue:38

    Topics: Aluminum Compounds; Amino Acid Sequence; Amino Acid Substitution; Bacterial Proteins; Crystallography, X-Ray; Dimerization; Fluorides; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine Diphosphate; Humans; Luminescent Proteins; Models, Molecular; Molecular Sequence Data; Protein Binding; Protein Structure, Secondary; Recombinant Fusion Proteins; RGS Proteins; Structure-Activity Relationship

2006
Expression, purification, and preliminary X-ray crystallographic analysis of the complex of G(alphai3)-RGS5 from human with GDP/Mg2+)/AlF4-.
    Protein and peptide letters, 2006, Volume: 13, Issue:9

    Topics: Aluminum Compounds; Crystallography, X-Ray; Fluorides; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Proteins; Guanosine Diphosphate; Humans; Magnesium; Molecular Sequence Data; Multiprotein Complexes; RGS Proteins; Second Messenger Systems

2006
Identification of functional domains in Arabidopsis thaliana mRNA decapping enzyme (AtDcp2).
    Nucleic acids research, 2008, Volume: 36, Issue:1

    Topics: Amino Acid Motifs; Amino Acid Sequence; Arabidopsis; Arabidopsis Proteins; Computational Biology; Endoribonucleases; Escherichia coli; Fluorides; Glutamic Acid; Guanosine Diphosphate; Histidine; Lysine; Molecular Sequence Data; Mutation; Phosphines; Protein Structure, Tertiary; Recombinant Fusion Proteins; RNA, Messenger; Sequence Deletion

2008
Visualization of the eEF2-80S ribosome transition-state complex by cryo-electron microscopy.
    Journal of molecular biology, 2008, Sep-26, Volume: 382, Issue:1

    Topics: Aluminum Compounds; Cryoelectron Microscopy; Fluorides; Fungal Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Hydrolysis; Models, Molecular; Peptide Elongation Factor 2; Protein Structure, Tertiary; Ribosomes

2008
G domain dimerization controls dynamin's assembly-stimulated GTPase activity.
    Nature, 2010, May-27, Volume: 465, Issue:7297

    Topics: Aluminum Compounds; Amino Acid Sequence; Biocatalysis; Catalytic Domain; Conserved Sequence; Crystallography, X-Ray; Dynamin I; Enzyme Activation; Fluorides; GTP Phosphohydrolases; Guanosine Diphosphate; Humans; Hydrolysis; Models, Molecular; Protein Multimerization; Protein Structure, Quaternary; Protein Structure, Tertiary; Sodium

2010
The initiation of GTP hydrolysis by the G-domain of FeoB: insights from a transition-state complex structure.
    PloS one, 2011, Volume: 6, Issue:8

    Topics: Aluminum Compounds; Amino Acid Sequence; Bacterial Proteins; Binding Sites; Biocatalysis; Cation Transport Proteins; Crystallography, X-Ray; Fluorides; GTP Phosphohydrolases; Guanosine Diphosphate; Guanosine Triphosphate; Hydrolysis; Models, Molecular; Molecular Sequence Data; Mutation; Potassium; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Streptococcus thermophilus; Substrate Specificity; Threonine; Water

2011
The structural basis of FtsY recruitment and GTPase activation by SRP RNA.
    Molecular cell, 2013, Dec-12, Volume: 52, Issue:5

    Topics: Aluminum Compounds; Bacterial Proteins; Base Sequence; Catalytic Domain; Escherichia coli; Escherichia coli Proteins; Fluorides; GTP Phosphohydrolase Activators; GTP Phosphohydrolases; Guanosine Diphosphate; Hydrolysis; Molecular Sequence Data; Receptors, Cytoplasmic and Nuclear; RNA; RNA, Bacterial; Sequence Analysis, DNA; Signal Recognition Particle

2013
Structural insights into G domain dimerization and pathogenic mutation of OPA1.
    The Journal of cell biology, 2020, 07-06, Volume: 219, Issue:7

    Topics: Beryllium; Binding Sites; Cloning, Molecular; Crystallography, X-Ray; Escherichia coli; Fluorides; Gene Expression; Genetic Vectors; GTP Phosphohydrolases; Guanosine Diphosphate; Humans; Liposomes; Magnesium; Models, Molecular; Mutation; Optic Atrophy; Potassium; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Protein Multimerization; Recombinant Proteins

2020