flunitrazepam has been researched along with zolpidem in 69 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (7.25) | 18.7374 |
| 1990's | 25 (36.23) | 18.2507 |
| 2000's | 27 (39.13) | 29.6817 |
| 2010's | 9 (13.04) | 24.3611 |
| 2020's | 3 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Cook, JM; Cox, ED; Diaz-Arauzo, H; Harris, B; Huang, Q; Ma, C; McKernan, R; Reddy, MS; Skolnick, P | 1 |
| Cook, JM; Dayer, CA; He, X; Huang, Q; Liu, R; Ma, C; McKernan, R; Wenger, GR; Yu, S | 1 |
| Chou, WH; McMahon, T; Messing, RO; Newton, PM; Qi, ZH; Shokat, KM; Song, M; Wallace, MJ; Wang, D; Zhang, C | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Alelyunas, YW; Bui, K; Empfield, JR; McCarthy, D; Pelosi-Kilby, L; Shen, C; Spreen, RC | 1 |
| Declerck, AC; O'Hanlon, JF; Ruwe, F; Vermeeren, A; Wauquier, A | 1 |
| Bacon, E; de Barry, J; Gombos, G | 1 |
| De Luca, C; De Medici, D; Massotti, M | 1 |
| Cesana, B; Frattola, L; Maggioni, M; Priore, P | 1 |
| Danielou, G; Lloyd, GK; Thuret, F | 1 |
| Schifano, F | 1 |
| Bensimon, G; Foret, J; Lacomblez, L; Simon, P; Thiercelin, JF; Warot, D | 1 |
| Aubier, M; Murciano, D; Palacios, S; Pariente, R | 1 |
| Benavides, J; Dubois, A; Morel, E; Peny, B; Perrault, G; Scatton, B; Zivkovic, B | 1 |
| Arbilla, S; Langer, SZ | 1 |
| Lloyd, KG; Zivkovic, B | 1 |
| Benavides, J; Dennis, T; Dubois, A; Scatton, B | 1 |
| Arbilla, S; Dubois, A; Langer, SZ; Niddam, R; Scatton, B | 1 |
| Cancedda, E; Corda, MG; Giorgi, O; Lecca, D; Serra, GP | 1 |
| Bannwarth, W; Benke, D; Fritschy, JM; Mohler, H; Trzeciak, A | 1 |
| Erickson, A; Hendrickson, A; March, D; Richards, G; Shaw, C | 1 |
| Machado, A; Ruano, D; Vitorica, J | 1 |
| Chiu, TH; Ramsey-Williams, V; Rosenberg, HC; Wu, Y | 1 |
| Balsamo, EL; Ciapparelli, A; Gemignani, A; Guazzelli, M; Sarteschi, P | 1 |
| Armengaud, MH; Aubier, M; Cramer, PH; L'Héritier, C; Murciano, D; Neveux, E; Pariente, R | 1 |
| Hadingham, KL; Palmer, KJ; Thompson, SA; Wafford, KA; Whiting, PJ | 1 |
| Crane, DI; Dodd, PR; Lewohl, JM | 1 |
| Biggio, G; Cagetti, E; Franco, M; Genchi, G; Latrofa, A; Liso, G; Ricciardi, L; Sanna, E; Trapani, G; Tuveri, F | 1 |
| Borderies, P; de La Giclais, B; Dujardin, K; Guieu, JD; Leconte, P; Leconte-Lambert, C | 1 |
| Atack, JR; McKernan, RM; Smith, AJ | 1 |
| Bailey, CD; Brien, JF; Reynolds, JN | 1 |
| Mehta, AK; Ticku, MK | 1 |
| Bocca, ML; Denise, P; Etard, O; L'Hoste, J; Le Doze, F; Pottier, M | 1 |
| Dawson, GR; Hirani, E; Hume, SP; Luthra, SK; Opacka-Juffry, J | 1 |
| Kellogg, CK; Roberts, AA | 1 |
| Alo', R; Canonaco, M; Facciolo, RM; Franzoni, MF; Tavolaro, R | 1 |
| Aller, MI; Araujo, F; Fernández-López, A; Gimenes, CC; Paniagua, MA; Vitorica, J | 1 |
| Bocca, ML; Denise, P | 2 |
| Betti, L; Bistocchi, M; Giannaccini, G; Gori, M; Lucacchini, A | 1 |
| Bromidge, FA; Casula, MA; Hadingham, KL; Martin, K; Maubach, K; Pillai, GV; Seabrook, GR; Whiting, PJ; Wingrove, PB | 1 |
| Safo, P; Thompson, SA; Wafford, KA; Wheat, L; Whiting, PJ; Wingrove, PB | 1 |
| Hodge, CW; Homanics, GE; Khisti, RT; Kralic, JE; Morrow, AL; O'Buckley, TK | 1 |
| Berkovic, SF; Bowser, DN; Cromer, BA; Czajkowski, C; Harkin, LA; Jones, MV; Marini, C; Mulley, JC; Parker, MW; Petrou, S; Wagner, DA; Wallace, RH; Williams, DA | 1 |
| Cook, JM; Lelas, S; Rowlett, JK; Spealman, RD; Yin, W | 1 |
| Berthelon, C; Bocca, ML; Denise, P; Pottier, A | 1 |
| Anisman, H; Caldji, C; Diorio, J; Meaney, MJ | 1 |
| Aller, MI; Capogna, M; Cope, DW; Ferraguti, F; Halbsguth, C; Hoeger, H; Jolin, HE; Jones, A; Korpi, ER; McKenzie, AN; Oberto, A; Ogris, W; Poeltl, A; Sieghart, W; Sigel, E; Sinkkonen, ST; Somogyi, P; Vekovischeva, OY; Wisden, W; Wulff, P | 1 |
| Fahey, JM; Grassi, JM; Greenblatt, DJ; Reddi, JM | 1 |
| Matlach, R; Ondra, P; Zedníková, K | 1 |
| Czajkowski, C; Ericksen, SS; Kucken, AM; Sancar, F; Teissére, JA | 1 |
| Lopes, DV; Mendonça-Silva, DL; Noël, F; Thibaut, JP | 1 |
| Holopainen, IE; Kukko-Lukjanov, TK; Laurén, HB; Lopez-Picon, FR; Uusi-Oukari, M | 1 |
| Angelatou, F; Matsokis, N; Papatheodoropoulos, C; Sarantis, K; Sotiriou, E | 1 |
| Bramness, JG; Engeland, A; Gustavsen, I; Mørland, J; Neutel, I; Skurtveit, S | 1 |
| Burin, E; Dally, S; Djezzar, S; Questel, F | 1 |
| Araki, H; Cui, R; Li, B; Suemaru, K; Tanaka, M; Watanabe, S | 1 |
| Berthelon, C; Bocca, ML; Denise, P; Marie, S; Meskali, M | 1 |
| Chèze, M; Deveaux, M; Hoizey, G; Muckensturm, A; Pépin, G | 1 |
| Jembrek, MJ; Pericić, D; Strac, DS; Vlainić, J | 1 |
| Jazvinšćak Jembrek, M; Peričić, D; Švob Štrac, D; Vlainić, J; Vlainić, T | 1 |
| Jembrek, MJ; Peričić, D; Strac, DŠ; Vlainić, J; Vlainić, T | 1 |
| Chang, YP; Chen, CS; Huang, MF; Ko, CH; Lin, JJ; Yeh, YC; Yen, CF; Yu, CY | 1 |
| Gonmori, K; Hasegawa, K; Minakata, K; Nozawa, H; Suzuki, O; Watanabe, K; Wurita, A; Yamagishi, I | 1 |
| Galizio, M; Mason, M; Mathews, M; Panoz-Brown, D; Prichard, A; Soto, P | 1 |
| Ahn, HJ; Chang, HJ; Cho, SU; Cho, YC; Jeong, WJ; Kang, CS; Kim, DW; Kim, KJ; Kim, MS; Kim, SC; Lee, JW; Min, JH; Oh, SK; Park, JS; Ryu, S; You, YH | 1 |
| Borriello, R; Campobasso, CP; Carfora, A; Cassandro, P; Petrella, R | 1 |
| Ishikawa, A; Kakehashi, H; Kamata, T; Katagi, M; Nakano-Fujii, S; Nitta, A; Sasaki, K; Sato, T; Shima, N; Wada, M | 1 |
11 trial(s) available for flunitrazepam and zolpidem
| Article | Year |
|---|---|
Effects of zolpidem and flunitrazepam on nocturnal sleep of women subjectively complaining of insomnia.
Topics: Adult; Double-Blind Method; Female; Flunitrazepam; Humans; Hypnotics and Sedatives; Pyridines; Sleep; Sleep Initiation and Maintenance Disorders; Sleep, REM; Zolpidem | 1992 |
Double blind comparison of zolpidem 20 mg versus flunitrazepam 2 mg in insomniac in-patients.
Topics: Adult; Aged; Double-Blind Method; Female; Flunitrazepam; Humans; Hypnotics and Sedatives; Middle Aged; Pyridines; Sleep; Sleep Initiation and Maintenance Disorders; Zolpidem | 1990 |
[Zolpidem tartrate].
Topics: Adult; Aged; Animals; Double-Blind Method; Flunitrazepam; Humans; Hypnotics and Sedatives; Mice; Pyridines; Randomized Controlled Trials as Topic; Rats; Sleep Initiation and Maintenance Disorders; Time Factors; Zolpidem | 1990 |
Daytime wakefulness following a bedtime oral dose of zolpidem 20 mg, flunitrazepam 2 mg and placebo.
Topics: Administration, Oral; Adult; Drug Evaluation; Flunitrazepam; Humans; Hypnotics and Sedatives; Male; Psychomotor Performance; Pyridines; Sleep; Surveys and Questionnaires; Wakefulness; Zolpidem | 1990 |
[Treatment of insomnia related to depressive disorders. Effects of zolpidem versus flunitrazepam administration and withdrawal evaluated in a double-blind study].
Topics: Adult; Depressive Disorder; Double-Blind Method; Flunitrazepam; Humans; Hypnotics and Sedatives; Male; Middle Aged; Psychiatric Status Rating Scales; Pyridines; Sleep Initiation and Maintenance Disorders; Surveys and Questionnaires; Treatment Outcome; Zolpidem | 1993 |
Acute effects of zolpidem, triazolam and flunitrazepam on arterial blood gases and control of breathing in severe COPD.
Topics: Blood Gas Analysis; Carbon Dioxide; Flunitrazepam; Humans; Hypnotics and Sedatives; Lung Diseases, Obstructive; Middle Aged; Oxygen; Pyridines; Respiration; Triazolam; Zolpidem | 1993 |
Comparison of the effects of zolpidem and flunitrazepam on sleep structure and daytime cognitive functions. A study of untreated unsomniacs.
Topics: Adult; Cognition; Flunitrazepam; GABA Modulators; Humans; Hypnotics and Sedatives; Male; Middle Aged; Polysomnography; Pyridines; Sleep; Sleep Initiation and Maintenance Disorders; Zolpidem | 1998 |
Residual effect of zolpidem 10 mg and zopiclone 7.5 mg versus flunitrazepam 1 mg and placebo on driving performance and ocular saccades.
Topics: Adult; Analysis of Variance; Anti-Anxiety Agents; Automobile Driving; Azabicyclo Compounds; Double-Blind Method; Female; Flunitrazepam; Half-Life; Humans; Hypnotics and Sedatives; Male; Piperazines; Pyridines; Saccades; Surveys and Questionnaires; Task Performance and Analysis; Zolpidem | 1999 |
Residual effects of hypnotics on disengagement of spatial attention.
Topics: Adult; Aged; Anti-Anxiety Agents; Attention; Azabicyclo Compounds; Cross-Over Studies; Double-Blind Method; Eye Movements; Female; Flunitrazepam; Humans; Hypnotics and Sedatives; Male; Middle Aged; Photic Stimulation; Piperazines; Psychomotor Performance; Pyridines; Space Perception; Zolpidem | 2000 |
Effects of zolpidem 10 mg, zopiclone 7.5 mg and flunitrazepam 1 mg on night-time motor activity.
Topics: Adult; Aged; Analysis of Variance; Azabicyclo Compounds; Circadian Rhythm; Cross-Over Studies; Double-Blind Method; Female; Flunitrazepam; Humans; Male; Middle Aged; Motor Activity; Piperazines; Pyridines; Zolpidem | 2003 |
Do zopiclone, zolpidem and flunitrazepam have residual effects on simulated task of collision anticipation?
Topics: Accidents, Traffic; Adult; Attention; Automobile Driving; Azabicyclo Compounds; Female; Flunitrazepam; Half-Life; Humans; Hypnotics and Sedatives; Male; Piperazines; Pyridines; Task Performance and Analysis; Time Factors; Zolpidem | 2003 |
58 other study(ies) available for flunitrazepam and zolpidem
| Article | Year |
|---|---|
Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (6-PBC) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (Zk 93423)
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Binding, Competitive; Carbolines; Cell Line; Cerebral Cortex; Drug Design; GABA Agonists; Humans; Male; Mice; Muscle Relaxation; Rats; Receptors, GABA-A; Recombinant Proteins; Seizures; Structure-Activity Relationship | 1998 |
Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach.
Topics: Animals; Benzodiazepines; Carbolines; Cell Line; Columbidae; Conditioning, Operant; Crystallography, X-Ray; Humans; Indoles; Ligands; Male; Models, Molecular; Pyrimidines; Quinolones; Radioligand Assay; Receptors, GABA-A; Saimiri; Stereoisomerism; Structure-Activity Relationship | 2000 |
Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits.
Topics: Adenosine Triphosphate; Allosteric Regulation; Animals; Benzodiazepines; Cells, Cultured; Enzyme Activation; Ethanol; Hippocampus; Humans; Mice; Mice, Knockout; Mutation; Phosphorylation; Protein Kinase C-epsilon; Protein Kinase Inhibitors; Protein Subunits; Pyridines; Receptors, GABA-A; Sensitivity and Specificity; Serine; Zolpidem | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate.
Topics: Central Nervous System Agents; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Solubility | 2010 |
Differential ontogenesis of type I and II benzodiazepine receptors in mouse cerebellum.
Topics: Aging; Animals; Cerebellum; Flunitrazepam; Mice; Models, Biological; Pyridazines; Pyridines; Receptors, GABA-A; Zolpidem | 1991 |
Relative efficacies of benzodiazepine receptor agonists in affecting red nucleus electrical activity in rabbits.
Topics: Animals; Bicuculline; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; Imidazoles; Isoquinolines; Male; Pentylenetetrazole; Pyridazines; Pyridines; Rabbits; Receptors, GABA-A; Red Nucleus; Zolpidem | 1990 |
The activity of zolpidem and other hypnotics within the gamma-aminobutyric acid (GABAA) receptor supramolecular complex, as determined by 35S-t-butylbicyclophosphorothionate (35S-TBPS) binding to rat cerebral cortex membranes.
Topics: Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Hypnotics and Sedatives; In Vitro Techniques; Male; Pyridines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Zolpidem | 1990 |
Comparison of zolpidem (Z), triazolam (T), and flunitrazepam (F) effects on arterial blood gases and control of breathing in patients with severe chronic obstructive pulmonary disease (COPD).
Topics: Flunitrazepam; Humans; Hypnotics and Sedatives; Lung Diseases, Obstructive; Pyridines; Respiratory Center; Triazolam; Zolpidem | 1990 |
In vivo interaction of zolpidem with central benzodiazepine (BZD) binding sites (as labeled by [3H]Ro 15-1788) in the mouse brain. Preferential affinity of zolpidem for the omega 1 (BZD1) subtype.
Topics: Animals; Autoradiography; Binding Sites; Brain; Flumazenil; Flunitrazepam; Hypnotics and Sedatives; In Vitro Techniques; Male; Mice; Pyridazines; Pyridines; Receptors, GABA-A; Zolpidem | 1988 |
Imidazopyridines as a tool for the characterization of benzodiazepine receptors: a proposal for a pharmacological classification as omega receptor subtypes.
Topics: Animals; Brain Chemistry; Flunitrazepam; GABA-A Receptor Antagonists; Imidazoles; In Vitro Techniques; Isoquinolines; Kidney; Ligands; Pyridazines; Pyridines; Rats; Receptors, GABA-A; Spinal Cord; Terminology as Topic; Zolpidem | 1988 |
Specificity within the GABAA receptor supramolecular complex: a consideration of the new omega 1-receptor selective imidazopyridine hypnotic zolpidem.
Topics: Animals; Diazepam; Flunitrazepam; Hypnotics and Sedatives; Male; Mice; Mice, Inbred Strains; Pyridines; Receptors, GABA-A; Zolpidem | 1988 |
Distribution of central omega 1 (benzodiazepine1) and omega 2 (benzodiazepine2) receptor subtypes in the monkey and human brain. An autoradiographic study with [3H]flunitrazepam and the omega 1 selective ligand [3H]zolpidem.
Topics: Animals; Autoradiography; Binding, Competitive; Brain Chemistry; Chlorocebus aethiops; Flunitrazepam; Humans; Pyridines; Receptors, GABA-A; Zolpidem | 1988 |
Autoradiographic localization of [3H]zolpidem binding sites in the rat CNS: comparison with the distribution of [3H]flunitrazepam binding sites.
Topics: Animals; Autoradiography; Binding Sites; Brain; Flunitrazepam; Pyridines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Spinal Cord; Tissue Distribution; Zolpidem | 1987 |
Modulation of [35S]TBPS binding by ligands with preferential affinity for benzodiazepine BZ1 sites in the cerebral cortex of newborn and adult rats.
Topics: Age Factors; Animals; Animals, Newborn; Binding Sites; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Female; Flunitrazepam; Male; Pregnancy; Pyridazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Zolpidem | 1995 |
Distribution, prevalence, and drug binding profile of gamma-aminobutyric acid type A receptor subtypes differing in the beta-subunit variant.
Topics: Animals; Brain Chemistry; Carbolines; Flumazenil; Flunitrazepam; Genetic Variation; Immunohistochemistry; Male; Microscopy, Confocal; Molecular Weight; Precipitin Tests; Protein Conformation; Pyridazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Tissue Distribution; Zolpidem | 1994 |
Coincidental appearance of the alpha 1 subunit of the GABA-A receptor and the type I benzodiazepine receptor near birth in macaque monkey visual cortex.
Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Antibodies, Monoclonal; Autoradiography; Binding, Competitive; Female; Flunitrazepam; Hypnotics and Sedatives; Immunohistochemistry; Ligands; Macaca nemestrina; Pregnancy; Pyridazines; Pyridines; Receptors, GABA-A; Visual Cortex; Zolpidem | 1994 |
Absence of modifications of the pharmacological properties of the GABAA receptor complex during aging, as assessed in 3- and 24-month-old rat cerebral cortex.
Topics: Affinity Labels; Aging; Animals; Anti-Anxiety Agents; Binding, Competitive; Cerebral Cortex; Flunitrazepam; Hypnotics and Sedatives; In Vitro Techniques; Male; Membrane Proteins; Muscimol; Photochemistry; Pyridazines; Pyridines; Rats; Rats, Inbred F344; Rats, Wistar; Receptors, GABA-A; Zolpidem | 1993 |
Regional changes in [3H]zolpidem binding to brain benzodiazepine receptors in flurazepam tolerant rat: comparison with changes in [3H]flunitrazepam binding.
Topics: Animals; Brain; Diazepam; Drug Tolerance; Flunitrazepam; Flurazepam; Male; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Tritium; Zolpidem | 1994 |
Expression and pharmacology of human GABAA receptors containing gamma 3 subunits.
Topics: Amino Acid Sequence; Animals; Anti-Anxiety Agents; Base Sequence; Benzodiazepines; Benzodiazepinones; Carbolines; Flumazenil; Flunitrazepam; GABA Modulators; Humans; Molecular Sequence Data; Pyrazoles; Pyridazines; Pyridines; Receptors, GABA-A; Recombinant Proteins; Sequence Homology, Amino Acid; Triazolam; Xenopus; Zolpidem | 1995 |
Zolpidem binding sites on the GABA(A) receptor in brain from human cirrhotic and non-cirrhotic alcoholics.
Topics: Adult; Aged; Aged, 80 and over; Alcoholism; Binding Sites; Brain; Female; Flunitrazepam; Frontal Lobe; Humans; Linear Models; Liver Cirrhosis, Alcoholic; Male; Middle Aged; Motor Cortex; Postmortem Changes; Pyridines; Receptors, GABA-A; RNA, Messenger; Up-Regulation; Zolpidem | 1997 |
Synthesis and binding affinity of 2-phenylimidazo[1,2-alpha]pyridine derivatives for both central and peripheral benzodiazepine receptors. A new series of high-affinity and selective ligands for the peripheral type.
Topics: Animals; Benzodiazepinones; Binding, Competitive; Brain; Female; Flunitrazepam; Humans; Hypnotics and Sedatives; Imidazoles; Kidney; Kinetics; Male; Mitochondria; Molecular Structure; Oocytes; Pyridines; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A; Recombinant Proteins; Structure-Activity Relationship; Xenopus laevis; Zolpidem | 1997 |
Benzodiazepine modulation of recombinant alpha1beta3gamma2 GABA(A) receptor function efficacy determination using the Cytosensor microphysiometer.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Biosensing Techniques; Cell Count; Cells, Cultured; Dose-Response Relationship, Drug; Eukaryotic Cells; Flumazenil; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Humans; Pyridines; Receptors, GABA-A; Recombinant Proteins; Time Factors; Zolpidem | 1998 |
Neurosteroid modulation of the GABAA receptor in the developing guinea pig cerebral cortex.
Topics: Animals; Benzodiazepines; Binding, Competitive; Brain Chemistry; Cerebral Cortex; Female; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Guinea Pigs; Hypnotics and Sedatives; Male; Muscimol; Organ Size; Pregnanolone; Pyridines; Radioligand Assay; Receptors, GABA-A; Tritium; Zolpidem | 1999 |
Prevalence of the GABAA receptor assemblies containing alpha1-subunit in the rat cerebellum and cerebral cortex as determined by immunoprecipitation: lack of modulation by chronic ethanol administration.
Topics: Affinity Labels; Alcoholism; Animals; Azides; Benzodiazepines; Brain Chemistry; Central Nervous System Depressants; Cerebellum; Cerebral Cortex; Chronic Disease; Ethanol; Flunitrazepam; GABA Agonists; GABA Modulators; Hypnotics and Sedatives; Male; Muscimol; Precipitin Tests; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Tritium; Zolpidem | 1999 |
Evaluation of [methyl-3H]L655,708 and [ethyl-3H]RY80 as putative PET ligands for central GABA(A) receptors containing alpha5 subunit.
Topics: Alkynes; Animals; Benzodiazepines; Brain; Flunitrazepam; GABA Modulators; Imidazoles; Ligands; Male; Pyridines; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Substrate Specificity; Tissue Distribution; Tomography, Emission-Computed; Zolpidem | 1999 |
Synchronous postnatal increase in alpha1 and gamma2L GABA(A) receptor mRNAs and high affinity zolpidem binding across three regions of rat brain.
Topics: Aging; Analysis of Variance; Animals; Binding Sites; Binding, Competitive; Brain; Cerebellum; Cerebral Cortex; Dose-Response Relationship, Drug; Female; Flunitrazepam; GABA Modulators; Gene Expression Regulation, Developmental; Hippocampus; Hypnotics and Sedatives; Male; Pyridines; Rats; Rats, Long-Evans; Receptors, GABA-A; Ribonucleases; RNA, Messenger; Zolpidem | 2000 |
Dimorphic features of the different alpha-containing GABA-A receptor subtypes in the cortico-basal ganglia system of two distantly related mammals (hedgehog and rat)
Topics: Animals; Autoradiography; Basal Ganglia; Brain; Cerebral Cortex; Female; Flunitrazepam; Hedgehogs; Kinetics; Male; Organ Specificity; Parietal Lobe; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sex Characteristics; Substantia Nigra; Thalamic Nuclei; Zolpidem | 2000 |
Distribution of the gamma-aminobutyric acid(A) receptor complex alpha 5 subunit in chick brain. An immunocytochemical and autoradiographic study.
Topics: Animals; Antibody Specificity; Autoradiography; Blotting, Western; Brain; Cerebellum; Chickens; Corpus Striatum; Diencephalon; Flunitrazepam; Immunohistochemistry; Male; Medulla Oblongata; Mesencephalon; Precipitin Tests; Pyridines; Rats; Receptors, GABA-A; Species Specificity; Superior Colliculi; Telencephalon; Zolpidem | 2000 |
[3H]Ro 15-1788 binding sites to brain membrane of the saltwater Mugil cephalus.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Carbolines; Cell Membrane; Chlorides; Diazepam; Female; Fishes; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Imidazoles; Ionophores; Male; Pyridines; Receptors, GABA-A; Synaptosomes; Tritium; Zolpidem | 2001 |
Identification of amino acid residues responsible for the alpha5 subunit binding selectivity of L-655,708, a benzodiazepine binding site ligand at the GABA(A) receptor.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Anti-Anxiety Agents; Azides; Benzodiazepines; Binding Sites; Binding, Competitive; Carbolines; DNA, Complementary; Female; Flumazenil; Flunitrazepam; GABA-A Receptor Agonists; Humans; Imidazoles; Isoleucine; Ligands; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Protein Binding; Protein Structure, Tertiary; Protein Subunits; Pyridazines; Pyridines; Receptors, GABA-A; Recombinant Fusion Proteins; Sequence Alignment; Structure-Activity Relationship; Threonine; Transfection; Xenopus laevis; Zolpidem | 2001 |
Mechanism of alpha-subunit selectivity of benzodiazepine pharmacology at gamma-aminobutyric acid type A receptors.
Topics: Animals; Anti-Anxiety Agents; Binding, Competitive; Cell Line; Diazepam; Dose-Response Relationship, Drug; Female; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Membrane Potentials; Mutation; Oocytes; Protein Subunits; Pyridazines; Pyridines; Radioligand Assay; Receptors, GABA-A; Tritium; Xenopus laevis; Zolpidem | 2002 |
GABA(A) receptor alpha-1 subunit deletion alters receptor subtype assembly, pharmacological and behavioral responses to benzodiazepines and zolpidem.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Benzodiazepines; Chlorides; Diazepam; Exploratory Behavior; Female; Flunitrazepam; GABA Agonists; GABA Modulators; Gene Deletion; Hypnotics and Sedatives; Male; Mice; Mice, Knockout; Motor Activity; Muscimol; Postural Balance; Pyridines; Radioligand Assay; Receptors, GABA-A; Seizures; Zolpidem | 2002 |
Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy.
Topics: Amino Acid Substitution; Animals; Anti-Anxiety Agents; Cell Line; Diazepam; Epilepsy; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Kinetics; Membrane Potentials; Mutagenesis, Site-Directed; Neurons; Oocytes; Patch-Clamp Techniques; Protein Subunits; Pyridines; Receptors, GABA-A; Recombinant Proteins; Synapses; Synaptic Transmission; Transfection; Xenopus; Zolpidem | 2002 |
Discriminative stimulus effects of zolpidem in squirrel monkeys: role of GABA(A)/alpha1 receptors.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Benzodiazepines; Carbolines; Discrimination Learning; Dose-Response Relationship, Drug; Flunitrazepam; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; Injections, Intravenous; Male; Pyridazines; Pyridines; Receptors, GABA-A; Saimiri; Zolpidem | 2003 |
Maternal behavior regulates benzodiazepine/GABAA receptor subunit expression in brain regions associated with fear in BALB/c and C57BL/6 mice.
Topics: Adoption; Analysis of Variance; Animals; Animals, Newborn; Anxiety; Autoradiography; Behavior, Animal; Brain; Exploratory Behavior; Fear; Female; Flunitrazepam; GABA Agonists; GABA Modulators; Gene Expression Regulation; In Situ Hybridization; Male; Maternal Behavior; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Protein Subunits; Pyridines; Radioligand Assay; Receptors, GABA-A; RNA, Messenger; Species Specificity; Zolpidem | 2004 |
Abolition of zolpidem sensitivity in mice with a point mutation in the GABAA receptor gamma2 subunit.
Topics: Amino Acid Substitution; Animals; Base Sequence; DNA Primers; Flunitrazepam; GABA Agonists; Mice; Mice, Mutant Strains; Point Mutation; Polymorphism, Single Nucleotide; Pyridines; Receptors, GABA-A; Zolpidem | 2004 |
Acute zolpidem administration produces pharmacodynamic and receptor occupancy changes at similar doses.
Topics: Animals; Anticonvulsants; Binding, Competitive; Convulsants; Dose-Response Relationship, Drug; Flunitrazepam; Hypnotics and Sedatives; Lorazepam; Male; Mice; Motor Activity; Pentylenetetrazole; Pyridines; Receptors, Drug; Receptors, GABA-A; Seizures; Zolpidem | 2006 |
Possibilities and problems with identification and determination of "new" hypnotics.
Topics: Chromatography, Gas; Flunitrazepam; Forensic Toxicology; Humans; Hypnotics and Sedatives; Pyridines; Substance Abuse Detection; Zolpidem | 2005 |
Structural determinants for high-affinity zolpidem binding to GABA-A receptors.
Topics: Binding Sites; Cloning, Molecular; Flunitrazepam; Hypnotics and Sedatives; Models, Molecular; Mutant Chimeric Proteins; Protein Conformation; Pyridines; Radioligand Assay; Receptors, GABA-A; Zolpidem | 2007 |
Characterization of two classes of benzodiazepine binding sites in Schistosoma mansoni.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Binding Sites; Clonazepam; Diazepam; Flunitrazepam; GABA Agonists; GABA Modulators; Inhibitory Concentration 50; Isoquinolines; Ligands; Male; Pyridines; Rats; Rats, Wistar; Receptors, GABA-A; Schistosoma mansoni; Synaptosomes; Temperature; Time Factors; Tritium; Zolpidem | 2007 |
Status epilepticus alters zolpidem sensitivity of [3H]flunitrazepam binding in the developing rat brain.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Autoradiography; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Flunitrazepam; GABA Agonists; GABA Modulators; Kainic Acid; Protein Binding; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Status Epilepticus; Zolpidem | 2007 |
Differential pharmacological properties of GABAA/benzodiazepine receptor complex in dorsal compared to ventral rat hippocampus.
Topics: Animals; Binding, Competitive; Dose-Response Relationship, Drug; Etomidate; Flunitrazepam; GABA Agonists; Hippocampus; Imidazoles; Male; Neurons; Organ Specificity; Protein Subunits; Pyridines; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A; Tritium; Zolpidem | 2008 |
Road traffic accident risk related to prescriptions of the hypnotics zopiclone, zolpidem, flunitrazepam and nitrazepam.
Topics: Accidents, Traffic; Adolescent; Adult; Aged; Azabicyclo Compounds; Female; Flunitrazepam; Follow-Up Studies; Humans; Hypnotics and Sedatives; Incidence; Male; Middle Aged; Nitrazepam; Norway; Piperazines; Pyridines; Risk Factors; Sleep Initiation and Maintenance Disorders; Young Adult; Zolpidem | 2008 |
Chemical submission: results of 4-year French inquiry.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Benzodiazepines; Bromazepam; Child; Child Abuse; Child, Preschool; Clonazepam; Crime; Data Collection; Female; Flunitrazepam; Homicide; Humans; Male; Middle Aged; Psychotropic Drugs; Pyridines; Rape; Sodium Oxybate; Theft; Young Adult; Zolpidem | 2009 |
Behavioral pharmacological properties after recovery from the loss of righting reflex induced by benzodiazepine receptor agonists in mice.
Topics: Animals; Azepines; Behavior, Animal; Dose-Response Relationship, Drug; Drug Interactions; Flunitrazepam; GABA Agonists; GABA-A Receptor Agonists; Hypnotics and Sedatives; Ketanserin; Male; Mice; Mice, Inbred Strains; Pyridines; Reflex; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Time Factors; Zolpidem | 2008 |
Residual effects of hypnotic drugs in aging drivers submitted to simulated accident scenarios: an exploratory study.
Topics: Accidents, Traffic; Anti-Anxiety Agents; Attention; Automobile Driving; Azabicyclo Compounds; Computer Simulation; Cross-Over Studies; Double-Blind Method; Female; Flunitrazepam; Humans; Hypnotics and Sedatives; Male; Middle Aged; Piperazines; Psychomotor Performance; Pyridines; Reaction Time; Suburban Population; Task Performance and Analysis; Zolpidem | 2009 |
A tendency for re-offending in drug-facilitated crime.
Topics: Adult; Anti-Anxiety Agents; Chromatography, Liquid; Clonazepam; Crime Victims; Doxylamine; Drug Combinations; Female; Flunitrazepam; Forensic Toxicology; Hair; Humans; Hypnotics and Sedatives; Limit of Detection; Lorazepam; Male; Mass Spectrometry; Middle Aged; Phenothiazines; Pyridines; Rape; Recurrence; Zolpidem | 2010 |
The effects of zolpidem treatment and withdrawal on the in vitro expression of recombinant alpha1beta2gamma2s GABA(A) receptors expressed in HEK 293 cells.
Topics: Animals; Binding Sites; Blotting, Western; Cell Line; Diazepam; Flunitrazepam; Humans; Hypnotics and Sedatives; Kidney; Protein Binding; Pyridines; Rats; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance Withdrawal Syndrome; Transfection; Up-Regulation; Zolpidem | 2010 |
The effects of zolpidem treatment on GABA(A) receptors in cultured cerebellar granule cells: changes in functional coupling.
Topics: Animals; Binding Sites; Binding, Competitive; Cell Membrane; Cells, Cultured; Cerebellum; Drug Tolerance; Flunitrazepam; GABA-A Receptor Agonists; Hypnotics and Sedatives; Polymerase Chain Reaction; Pyridines; Rats; Receptors, GABA-A; Zolpidem | 2012 |
Differential effects of short- and long-term zolpidem treatment on recombinant α1β2γ2s subtype of GABA(A) receptors in vitro.
Topics: Analysis of Variance; Binding, Competitive; Cell Culture Techniques; Cell Membrane; Flunitrazepam; GABA-A Receptor Agonists; HEK293 Cells; Humans; Protein Binding; Pyridines; Radioligand Assay; Receptors, GABA-A; Time Factors; Transfection; Zolpidem | 2012 |
Dependence, misuse, and beliefs regarding use of hypnotics by elderly psychiatric patients taking zolpidem, estazolam, or flunitrazepam.
Topics: Aged; Attitude to Health; Estazolam; Female; Flunitrazepam; Humans; Hypnotics and Sedatives; Male; Psychiatric Status Rating Scales; Pyridines; Sex Factors; Sleep Initiation and Maintenance Disorders; Substance-Related Disorders; Zolpidem | 2015 |
MALDI-TOF mass spectrometric determination of eight benzodiazepines with two of their metabolites in blood.
Topics: Azabicyclo Compounds; Benzodiazepines; Flunitrazepam; Humans; Piperazines; Pyridines; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry; Zolpidem | 2015 |
Amnestic drugs in the odor span task: Effects of flunitrazepam, zolpidem and scopolamine.
Topics: Amnesia; Animals; Cholinergic Antagonists; Discrimination, Psychological; Dose-Response Relationship, Drug; Flunitrazepam; GABA Modulators; GABA-A Receptor Agonists; Male; Memory, Short-Term; Neurotransmitter Agents; Odorants; Olfactory Perception; Pyridines; Rats, Sprague-Dawley; Scopolamine; Zolpidem | 2017 |
Serial plasma and urine measurements of a patient with acute intoxication of zolpidem and flunitrazepam resulting in QT prolongation and ventricular tachycardia.
Topics: Aged; Electrocardiography; Female; Flunitrazepam; Humans; Long QT Syndrome; Poisoning; Tachycardia, Ventricular; Zolpidem | 2020 |
Long-Term Detection in Hair of Zolpidem, Oxazepam and Flunitrazepam in a Case of Drug-Facilitated Sexual Assault.
Topics: Female; Flunitrazepam; Forensic Toxicology; Humans; Male; Middle Aged; Oxazepam; Pharmaceutical Preparations; Sex Offenses; Substance Abuse Detection; Zolpidem | 2022 |
Incorporation of five common hypnotics into hair after a single dose and application to a forensic case of drug facilitated crimes.
Topics: Adult; Asian People; Chromatography, Liquid; Crime; Diazepam; Female; Flunitrazepam; Forensic Toxicology; Hair; Humans; Hypnotics and Sedatives; Male; Mass Spectrometry; Nitrazepam; Substance Abuse Detection; Triazolam; Zolpidem | 2021 |