flunitrazepam and propofol

flunitrazepam has been researched along with propofol in 33 studies

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.03)18.7374
1990's21 (63.64)18.2507
2000's8 (24.24)29.6817
2010's3 (9.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chang, TK; Ensom, MH; Kiang, TK1
Lombardo, F; Obach, RS; Waters, NJ1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Prince, RJ; Simmonds, MA2
Biggio, G; Concas, A; Gessa, GL; Peduto, VA; Santoro, G1
D'Agostino, C; Fantera, A; Fegiz, A; Fioriti, A; Giancotti, C; Iannarone, C; Tellan, G1
Biggio, G; Concas, A; Sanna, E; Santoro, G; Serra, M1
Keller, I; Klasing, S; Madler, C; Schlund, M; Schwender, D1
Amicucci, G; Ardigò, M; Candiani, A; Ferrazin, FR; Scipione, V; Zappa, S1
Ardilouze, M; d'Athis, F; Dattez, C; Eledjam, JJ; Raulo, A; Rubio, C1
Faber-Züllig, E; Klasing, S; Peter, K; Pöppel, E; Schwender, D1
Faber-Züllig, E; Golling, W; Klasing, S; Peter, K; Pöppel, E; Schwender, D1
Kaiser, A; Klasing, S; Peter, K; Pöppel, E; Schwender, D1
Haessler, R; Klasing, S; Leppmeier, U; Peter, K; Rindfleisch, F; Schwender, D1
Hecketsweiler, B; Kaeffer, N; Moore, N; Moritz, F; Oksenhendler, G; Papion, H; Petit, J; Winckler, C1
Biggio, G; Ghiani, CA; Maciocco, E; Sanna, E; Serra, M; Tuligi, G1
Bennett, PJ; Simmonds, MA1
Simmonds, MA; Zhong, Y1
Davies, PA; Hales, TG; Hanna, MC; Kirkness, EF1
Haberstroh, J; Karzai, W; Müller, W; Priebe, HJ1
Davies, M; Dunn, SM; Thuynsma, RP1
Bruner, KR; Reynolds, JN1
Fukuda, K; Ichinohe, T; Kaneko, Y; Kasahara, M; Mamiya, H; Noma, T1
Ai, J; Kahnberg, P; Nielsen, M; Saederup, E; Squires, RF; Sterner, O; Witt, MR1
Simmonds, MA; Sooksawate, T1
Davies, PA; Hales, TG; Kirkness, EF1
Asproni, B; Biggio, G; Busonero, F; Cerri, R; Maciocco, E; Mascia, MP; Pau, A; Sanna, E; Talani, G1
Bujons, J; García, DA; Suñol, C; Vale, C1
Bourgaux, C; Chanques, G; de La Coussaye, JE; Fabbro-Peray, P; Jaber, S; Lefrant, JY; Louart, G; Muller, L; Ripart, J1
Betts, BA; Gill, N; Griffith, TN; Hall, AC; Humbert, DJ; Jenkins, A; Kelly, EW; Kotey, FO; Rowan, KC; Veneskey, KC; Watt, EE1
Beynon, C; Hertle, DN; Neumann, JO; Sakowitz, OW; Sánchez-Porras, R; Santos, E; Unterberg, AW1
Alderson, P; Lewis, SR; Schofield-Robinson, OJ; Smith, AF1

Reviews

2 review(s) available for flunitrazepam and propofol

ArticleYear
UDP-glucuronosyltransferases and clinical drug-drug interactions.
    Pharmacology & therapeutics, 2005, Volume: 106, Issue:1

    Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic

2005
Propofol for the promotion of sleep in adults in the intensive care unit.
    The Cochrane database of systematic reviews, 2018, Jan-08, Volume: 1

    Topics: Adult; Dyssomnias; Flunitrazepam; Humans; Hypnotics and Sedatives; Intensive Care Units; Midazolam; Propofol; Randomized Controlled Trials as Topic; Sleep

2018

Trials

7 trial(s) available for flunitrazepam and propofol

ArticleYear
[Acoustic evoked potentials of medium latency and intraoperative wakefulness during anesthesia maintenance using propofol, isoflurane and flunitrazepam/fentanyl].
    Der Anaesthesist, 1991, Volume: 40, Issue:4

    Topics: Adult; Anesthesia, General; Evoked Potentials, Auditory; Fentanyl; Flunitrazepam; Humans; Intraoperative Period; Isoflurane; Middle Aged; Propofol; Wakefulness

1991
Motor signs of wakefulness during general anaesthesia with propofol, isoflurane and flunitrazepam/fentanyl and midlatency auditory evoked potentials.
    Anaesthesia, 1994, Volume: 49, Issue:6

    Topics: Adult; Anesthesia, Epidural; Anesthesia, General; Cough; Evoked Potentials, Auditory; Female; Fentanyl; Flunitrazepam; Hemodynamics; Humans; Isoflurane; Middle Aged; Motor Neurons; Movement; Propofol; Statistics as Topic; Wakefulness

1994
Effects of surgical stimulation on midlatency auditory evoked potentials during general anaesthesia with propofol/fentanyl, isoflurane/fentanyl and flunitrazepam/fentanyl.
    Anaesthesia, 1994, Volume: 49, Issue:7

    Topics: Anesthesia, General; Anesthetics; Cardiac Surgical Procedures; Dermatologic Surgical Procedures; Evoked Potentials, Auditory; Fentanyl; Flunitrazepam; Hemodynamics; Humans; Isoflurane; Propofol; Sternum

1994
Midlatency auditory evoked potentials and explicit and implicit memory in patients undergoing cardiac surgery.
    Anesthesiology, 1994, Volume: 80, Issue:3

    Topics: Aged; Anesthesia, General; Awareness; Cardiac Surgical Procedures; Dose-Response Relationship, Drug; Evoked Potentials, Auditory, Brain Stem; Female; Fentanyl; Flunitrazepam; Humans; Intraoperative Period; Isoflurane; Male; Memory; Memory, Short-Term; Middle Aged; Monitoring, Intraoperative; Propofol

1994
Anaesthesia for coronary artery bypass grafting: opioid-analgesia combined with either flunitrazepam, propofol or isoflurane.
    Acta anaesthesiologica Scandinavica, 1993, Volume: 37, Issue:6

    Topics: Adult; Aged; Analgesia; Anesthesia, General; Blood Pressure; Coronary Artery Bypass; Electrocardiography; Evoked Potentials, Auditory; Female; Fentanyl; Flunitrazepam; Heart Rate; Hemodynamics; Humans; Isoflurane; Male; Middle Aged; Propofol; Prospective Studies; Reaction Time; Stroke Volume

1993
Metabolic effects of propofol and flunitrazepam given for sedation after aortic surgery.
    British journal of anaesthesia, 1993, Volume: 70, Issue:4

    Topics: Aortic Aneurysm, Abdominal; Blood Pressure; Energy Metabolism; Flunitrazepam; Humans; Norepinephrine; Oxygen Consumption; Postoperative Care; Propofol; Time Factors

1993
Pain following intravenous administration of sedative agents: a comparison of propofol with three benzodiazepines.
    Anesthesia progress, 1998,Winter, Volume: 45, Issue:1

    Topics: Adult; Analysis of Variance; Anesthetics, Intravenous; Anesthetics, Local; Anti-Anxiety Agents; Cross-Over Studies; Diazepam; Double-Blind Method; Drug Combinations; Female; Flunitrazepam; Humans; Injections, Intravenous; Lidocaine; Male; Midazolam; Pain; Pain Measurement; Propofol; Prospective Studies

1998

Other Studies

24 other study(ies) available for flunitrazepam and propofol

ArticleYear
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Temperature and anion dependence of allosteric interactions at the gamma-aminobutyric acid-benzodiazepine receptor.
    Biochemical pharmacology, 1992, Oct-06, Volume: 44, Issue:7

    Topics: Animals; Anions; Binding, Competitive; Brain Chemistry; Drug Interactions; Flunitrazepam; Male; Pentobarbital; Pregnanediones; Propofol; Rats; Rats, Wistar; Receptors, GABA-A; Temperature

1992
Propofol potentiates the binding of [3H]flunitrazepam to the GABAA receptor complex.
    Brain research, 1992, Nov-20, Volume: 596, Issue:1-2

    Topics: Animals; Binding, Competitive; Drug Synergism; Flunitrazepam; Male; Pentobarbital; Pregnanediones; Propofol; Rats; Rats, Wistar; Receptors, GABA-A; Tritium

1992
Biochemical and electrophysiologic evidence that propofol enhances GABAergic transmission in the rat brain.
    Anesthesiology, 1991, Volume: 75, Issue:6

    Topics: Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chloride Channels; Dose-Response Relationship, Drug; Flunitrazepam; gamma-Aminobutyric Acid; Male; Membrane Proteins; Propofol; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptic Transmission

1991
[Total intravenous anesthesia (TIVA): clinical comparison of 2 pharmacologic combinations: flunitrazepam-droperidol-fentanyl and propofol-droperidol-fentanyl].
    Minerva anestesiologica, 1991, Volume: 57, Issue:9

    Topics: Adult; Anesthesia, Intravenous; Droperidol; Female; Fentanyl; Flunitrazepam; Humans; Male; Middle Aged; Propofol

1991
Neurochemical action of the general anaesthetic propofol on the chloride ion channel coupled with GABAA receptors.
    Brain research, 1991, Mar-01, Volume: 542, Issue:2

    Topics: Anesthetics; Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chloride Channels; Chlorides; Flunitrazepam; Male; Membrane Proteins; Muscimol; Propofol; Rats; Rats, Inbred Strains; Receptors, GABA-A

1991
[Sedation in spontaneous respiration in children during radiologic tests].
    Minerva anestesiologica, 1990, Volume: 56, Issue:9

    Topics: Child, Preschool; Conscious Sedation; Female; Flunitrazepam; Humans; Infant; Male; Propofol; Radiography; Respiration

1990
[Sedation with high epidural anesthesia in digestive surgery. Propofol versus flunitrazepam-enflurane].
    Annales francaises d'anesthesie et de reanimation, 1987, Volume: 6, Issue:4

    Topics: Anesthesia Recovery Period; Anesthesia, Epidural; Anesthetics; Digestive System Surgical Procedures; Enflurane; Flunitrazepam; Humans; Phenols; Propofol

1987
Biochemical evaluations of the effects of loreclezole and propofol on the GABAA receptor in rat brain.
    Biochemical pharmacology, 1996, Jun-14, Volume: 51, Issue:11

    Topics: Anesthetics; Animals; Anticonvulsants; Brain; Bridged Bicyclo Compounds, Heterocyclic; Diazepam; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Hypnotics and Sedatives; In Vitro Techniques; Male; Muscimol; Pentobarbital; Pregnanediones; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sulfur Radioisotopes; Triazoles; Tritium

1996
The influence of membrane cholesterol on the GABAA receptor.
    British journal of pharmacology, 1996, Volume: 117, Issue:1

    Topics: Animals; Brain; Cerebellum; Cerebral Cortex; Cholesterol; Dose-Response Relationship, Drug; Drug Interactions; Flunitrazepam; GABA Agents; Liposomes; Male; Muscimol; Pregnanolone; Propofol; Rats; Rats, Wistar; Receptors, GABA-A; Spinal Cord; Synaptic Membranes

1996
Pharmacological characterisation of multiple components in the enhancement by pregnanolone and propofol of [3H]flunitrazepam binding to GABAA receptors.
    Neuropharmacology, 1996, Volume: 35, Issue:9-10

    Topics: Anesthetics, Intravenous; Animals; Bicuculline; Flunitrazepam; GABA Agonists; GABA Modulators; In Vitro Techniques; Male; Muscimol; Pregnanolone; Progesterone; Propofol; Rats; Rats, Wistar; Receptors, GABA-A; Synaptic Membranes

1996
Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit.
    Nature, 1997, Feb-27, Volume: 385, Issue:6619

    Topics: Amino Acid Sequence; Anesthetics, Intravenous; Animals; Bicuculline; Brain; Cell Line; Consensus Sequence; DNA, Complementary; Flumazenil; Flunitrazepam; GABA Agents; gamma-Aminobutyric Acid; Humans; Molecular Sequence Data; Muscimol; Pentobarbital; Picrotoxin; Pregnanolone; Propofol; Rats; Receptors, GABA-A; Recombinant Proteins; RNA, Messenger; Transfection

1997
Rapid increase in inspired desflurane concentration does not elicit a hyperdynamic circulatory response in the pig.
    Laboratory animals, 1997, Volume: 31, Issue:3

    Topics: Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Blood Pressure; Catecholamines; Desflurane; Epinephrine; Female; Flunitrazepam; GABA Modulators; Heart Rate; Hemodynamics; Isoflurane; Male; Neuromuscular Nondepolarizing Agents; Preanesthetic Medication; Propofol; Swine; Time Factors; Vecuronium Bromide

1997
Effects of propofol and pentobarbital on ligand binding to GABAA receptors suggest a similar mechanism of action.
    Canadian journal of physiology and pharmacology, 1998, Volume: 76, Issue:1

    Topics: Allosteric Site; Anesthetics, Intravenous; Animals; Azides; Benzodiazepines; Brain; Cattle; Flunitrazepam; GABA Agonists; In Vitro Techniques; Ligands; Membranes; Muscimol; Pentobarbital; Propofol; Receptors, GABA-A

1998
Propofol modulation of [3H]flunitrazepam binding to GABAA receptors in guinea pig cerebral cortex.
    Brain research, 1998, Sep-21, Volume: 806, Issue:1

    Topics: Anesthetics, Intravenous; Animals; Anti-Anxiety Agents; Binding, Competitive; Cerebral Cortex; Drug Synergism; Flunitrazepam; GABA Modulators; Guinea Pigs; Male; Propofol; Receptors, GABA-A; Tritium

1998
Honokiol and magnolol increase the number of [3H] muscimol binding sites three-fold in rat forebrain membranes in vitro using a filtration assay, by allosterically increasing the affinities of low-affinity sites.
    Neurochemical research, 1999, Volume: 24, Issue:12

    Topics: Allosteric Regulation; Androstanes; Animals; Azasteroids; Binding Sites; Biphenyl Compounds; Cell Membrane; Central Nervous System Depressants; Cerebellum; Diflunisal; Drugs, Chinese Herbal; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Kinetics; Lignans; Muscimol; Picrotoxin; Propofol; Prosencephalon; Rats; Receptors, GABA-A; Tritium

1999
Influence of membrane cholesterol on modulation of the GABA(A) receptor by neuroactive steroids and other potentiators.
    British journal of pharmacology, 2001, Volume: 134, Issue:6

    Topics: Animals; Cell Membrane; Cholesterol; Dose-Response Relationship, Drug; Drug Synergism; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pentobarbital; Pregnanolone; Pregnenolone; Propofol; Rats; Rats, Wistar; Receptors, GABA-A

2001
Evidence for the formation of functionally distinct alphabetagammaepsilon GABA(A) receptors.
    The Journal of physiology, 2001, Nov-15, Volume: 537, Issue:Pt 1

    Topics: Anesthetics, Intravenous; Cell Line; Drug Synergism; Electric Conductivity; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Humans; Ion Channels; Propofol; Protein Isoforms; Receptors, GABA-A

2001
Ethyl 2-(4-bromophenyl)-1-(2,4-dichlorophenyl)-1H-4-imidazolecarboxylate is a novel positive modulator of GABAA receptors.
    European journal of pharmacology, 2005, Jun-15, Volume: 516, Issue:3

    Topics: Animals; Binding, Competitive; Cell Membrane; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Etomidate; Female; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Glycine; Humans; Hydrocarbons, Halogenated; Imidazoles; Male; Membrane Potentials; Oocytes; Pentobarbital; Pregnanediones; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glycine; Receptors, Serotonin, 5-HT3; Serotonin; Tritium; Xenopus laevis

2005
Allosteric positive interaction of thymol with the GABAA receptor in primary cultures of mouse cortical neurons.
    Neuropharmacology, 2006, Volume: 50, Issue:1

    Topics: Anesthetics, Intravenous; Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Chloride Channels; Computer Simulation; Female; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; L-Lactate Dehydrogenase; Mice; Models, Molecular; Models, Neurological; Muscimol; Neurons; Neurotoxins; Pregnancy; Propidium; Propofol; Receptors, GABA-A; Thymol

2006
Impact of the use of propofol remifentanil goal-directed sedation adapted by nurses on the time to extubation in mechanically ventilated ICU patients: the experience of a French ICU.
    Annales francaises d'anesthesie et de reanimation, 2008, Volume: 27, Issue:6

    Topics: Anesthetics, Intravenous; Flunitrazepam; France; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Intensive Care Units; Midazolam; Pain Measurement; Piperidines; Propofol; Remifentanil; Respiration, Artificial; Survival Rate; Treatment Outcome

2008
Menthol shares general anesthetic activity and sites of action on the GABA(A) receptor with the intravenous agent, propofol.
    European journal of pharmacology, 2008, Aug-20, Volume: 590, Issue:1-3

    Topics: Anesthetics, General; Anesthetics, Intravenous; Animals; Cyclohexanols; Flumazenil; Flunitrazepam; Menthol; Pentobarbital; Pregnanolone; Propofol; Receptors, GABA-A; Xenopus

2008
Use of GABAergic sedatives after subarachnoid hemorrhage is associated with worse outcome-preliminary findings.
    Journal of clinical anesthesia, 2016, Volume: 35

    Topics: Adult; Aged; Brain; Conscious Sedation; Female; Flunitrazepam; GABA Modulators; Glasgow Coma Scale; Humans; Hypnotics and Sedatives; Male; Midazolam; Middle Aged; Propofol; Regeneration; Retrospective Studies; Subarachnoid Hemorrhage

2016