flunitrazepam and midazolam

flunitrazepam has been researched along with midazolam in 82 studies

Research

Studies (82)

Timeframe	Studies, this research(%)	All Research%
pre-1990	33 (40.24)	18.7374
1990's	22 (26.83)	18.2507
2000's	18 (21.95)	29.6817
2010's	9 (10.98)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Lombardo, F; Obach, RS; Waters, NJ	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Alelyunas, YW; Bui, K; Empfield, JR; McCarthy, D; Pelosi-Kilby, L; Shen, C; Spreen, RC	1
Heinze, J; Rohrbach, M	1
Chaptal, PA; Colson, P; Cuchet, D; Grolleau, D; Médioni, P; Roquefeuil, B; Saussine, M; Séguin, JR	1
Fuji, K; Miyamoto, K; Okuda, T; Suekane, K; Wakita, K	1
Hashimoto, Y; Iwatsuki, N; Kato, M; Koga, Y; Sato, S; Sodeyama, N; Takahashi, M	1
Breimer, DD; de Boer, AG; van Hoogdalem, E	1
Galletly, DC; Short, TG	1
Ben-Ari, Y; Rovira, C	1
Daubländer, M; Lipp, M	1
Kataja, J; Kaukinen, L; Kaukinen, S	1
Doenicke, A; Greim, M; Juhl, G; Rampf, U; Suttmann, H	1
Stumpf, C; Viernstein, H	1
Keller, I; Klasing, S; Madler, C; Schwender, D	1
Hole, K; Rosland, JH	1
Ikeda, H; Robbins, J	1
du Cailar, J; Kienlen, J	1
Klotz, U	1
Wolff, J	1
Amrein, R; Hartmann, D; Hetzel, W; Lorscheid, T	1
Angelides, KJ; Barnes, EM; Thompson, CL; Velazquez, JL	1
Hack, G; Hermanns, E; Murday, HK; Rudolph, A	1
Boros, M; Falkay, G; Kertész, A	1
Aaltonen, L; Aantaa, E; Kanto, J; Salonen, M	1
Ambrose, F; Barbaz, B; Bittiger, H; Iyengar, S; Neale, RF; Petrack, B; Rinehart, RK; Steel, DJ; Williams, M; Wood, PL	1
Laqua, F; Prager, J; Tolksdorf, W	1
Badran, I; Hunjul, N; Sbeih, Z; Takrouri, MS; Toukan, A	1
Lanore, JJ; Manfredi, R; Sockeel, F; Tannières, ML; Vourc'h, G	1
Deschodt, J; du Cailar, J; Kienlen, J; Lubrano, JF	1
Berger, M; Brandstetter, A; Chowanetz, E; Gasser, G; Mossig, H; Schmidt, P	1
Igarasi, A; Ogawa, H; Sengoku, K; Takahata, O; Yurino, M	1
Fanard, L; Van der Puyl, F; Van Steenberge, A	1
Fejfar, Z; Hess, L; Vrána, M; Vránová, Z	1
Auneau, C; Blanloeil, Y; Cozian, A; Helias, J; Lepage, JY; Pinaud, M; Souron, R	1
Braestrup, C; Honoré, T; Nielsen, M	1
Dudkiewicz, J; Misterek, K	1
Lauven, PM; Schüttler, J; Schwilden, H; Stoeckel, H	1
Forster, A; Gardaz, JP; Gemperle, M; Morel, D; Suter, PM	1
Kangas, L; Kanto, J; Pakkanen, A; Sjövall, S	1
Bratlid, T; Gordeladze, JO; Lingjaerde, O; Westby, OC	1
Aliot, E; Boileau, S; Borgo, J; Laxenaire, MC; Royer, E	1
Marias, J; Scherschlicht, R	1
Breimer, DD; Jochemsen, R	1
Borbély, AA	1
Doenicke, A	1
Bonnard, M; Haberer, JP; Holzer, J; Schoeffler, P; Voitellier, E	1
du Cailar, J; Julia, JM; Jullien, Y; Ricard, C; Rochette, A	1
Haldemann, G; Weber, J	1
Adachi, M; Akatsu, M; Okuaki, A; Sinoda, M; Tase, C; Terashima, M; Watanabe, K	1
Estève, C; Hamza, J; Saint-Maurice, C	1
Cnossen, F; de Jong, HT; Jackson, JL; Louwerens, JW	1
Kashimoto, S; Kumazawa, T; Nakamura, T; Nonaka, A	1
Di Florio, T; Goucke, R	1
Klasing, S; Madler, C; Peter, K; Pöppel, E; Schwender, D	1
Kanayama, T; Koshikawa, N; Murai, T; Takada, K	1
Alihanka, J; Himberg, JJ; Kanto, J; Rajala, T; Seppälä, M; Sourander, L	1
Fukuda, K; Ichinohe, T; Kaneko, Y; Kasahara, M; Mamiya, H; Noma, T	1
Cleton, A; Danhof, M; Ghijsen, W; Odman, J; Van der Graaf, PH; Voskuyl, R	1
Krumholz, W; Menges, T; Weidenbusch, H	1
El Mahjoub, A; Staub, C	1
Cheeta, S; File, SE; Irvine, EE; Lovelock, C	1
Frerichs, A; Hellige, G; Kettler, D; Klockgether-Radke, AP; Thudium, A	1
Gedge, JI; Harris, SR; Nedderman, AN; Roffey, SJ; Savage, M	1
Caruso, RR; Castro, NG; Costa, PR; da Silva, AJ; Lopes, DV; Noël, F	1
Calamia, JC; Glodowski, M; Huang, W; Isoherranen, N; Lin, YS; McConn, DJ; Thummel, KE; Totah, RA	1
Briellmann, TA; Dussy, FE; Hamberg, C	1
Matsuo, N; Morita, T	2
Collins, H; Cox, RF; Feldman, PL; Kilpatrick, GJ; Lovell, GG; McIntyre, MS; Pacofsky, GJ; Stafford, JA; Tilbrook, GS; Waszczak, BL; Wiard, RP	1
Galetin, A; Hallifax, D; Houston, JB	1
Bourgaux, C; Chanques, G; de La Coussaye, JE; Fabbro-Peray, P; Jaber, S; Lefrant, JY; Louart, G; Muller, L; Ripart, J	1
Gerak, LR	1
Douglas, SA; Furukawa, K; Hashiba, E; Hirota, K; Kawaguchi, Y; Kudo, M; Kudo, T; Kushikata, T; Ono, T; Yoshida, H	1
Gunn, J; Kriger, S; Terrell, AR	1
Bai, X; Gerak, LR	1
France, CP; Gerak, LR	2
Kaneishi, K; Kawabata, M; Morita, T	1
Beynon, C; Hertle, DN; Neumann, JO; Sakowitz, OW; Sánchez-Porras, R; Santos, E; Unterberg, AW	1
Alderson, P; Lewis, SR; Schofield-Robinson, OJ; Smith, AF	1

Reviews

7 review(s) available for flunitrazepam and midazolam

Article	Year
Pharmacokinetics of rectal drug administration, Part I. General considerations and clinical applications of centrally acting drugs. Clinical pharmacokinetics, 1991, Volume: 21, Issue:1 Topics: Administration, Rectal; Antiemetics; Atropine; Carbamazepine; Clonazepam; Delayed-Action Preparations; Diazepam; Flunitrazepam; Humans; Hydromorphone; Intestinal Absorption; Methadone; Methohexital; Midazolam; Morphine; Pharmacokinetics; Phenobarbital; Valproic Acid	1991
[Pharmacology of midazolam]. Annales francaises d'anesthesie et de reanimation, 1987, Volume: 6, Issue:5 Topics: Anesthesia, General; Brain; Diazepam; Drug Interactions; Flunitrazepam; Hemodynamics; Humans; Midazolam; Preanesthetic Medication; Receptors, GABA-A; Respiration	1987
Flumazenil for post-operative recovery after general anaesthesia. European journal of anaesthesiology. Supplement, 1988, Volume: 2 Topics: Anesthesia, General; Double-Blind Method; Flumazenil; Flunitrazepam; Humans; Midazolam; Postoperative Care; Random Allocation; Receptors, GABA-A	1988
Clinical pharmacology of flumazenil. European journal of anaesthesiology. Supplement, 1988, Volume: 2 Topics: Animals; Flumazenil; Flunitrazepam; Humans; Mathematics; Midazolam; Receptors, GABA-A; Sleep	1988
[Current intravenous anesthetics]. Polski tygodnik lekarski (Warsaw, Poland : 1960), 1980, Volume: 35, Issue:43 Topics: Anesthesia, Intravenous; Anesthetics; Anti-Anxiety Agents; Benzodiazepines; Diazepam; Etomidate; Flunitrazepam; Imidazoles; Injections, Intravenous; Lorazepam; Medazepam; Midazolam; Nordazepam	1980
Modern trends in the investigation of new hypnotics in anaesthesia. Psychopharmacology. Supplementum, 1984, Volume: 1 Topics: Anesthesia; Anti-Anxiety Agents; Arousal; Benzodiazepines; Electroencephalography; Electrophysiology; Flunitrazepam; Half-Life; Humans; Hypnotics and Sedatives; Lorazepam; Midazolam; Psychometrics	1984
Propofol for the promotion of sleep in adults in the intensive care unit. The Cochrane database of systematic reviews, 2018, Jan-08, Volume: 1 Topics: Adult; Dyssomnias; Flunitrazepam; Humans; Hypnotics and Sedatives; Intensive Care Units; Midazolam; Propofol; Randomized Controlled Trials as Topic; Sleep	2018

Trials

23 trial(s) available for flunitrazepam and midazolam

Article	Year
[Premedication in retrobulbar anesthesia. A blood gas analysis comparison of sublingual flunitrazepam and intravenous midazolam]. Der Anaesthesist, 1992, Volume: 41, Issue:11 Topics: Administration, Sublingual; Aged; Aged, 80 and over; Carbon Dioxide; Cataract Extraction; Female; Flunitrazepam; Humans; Injections, Intravenous; Male; Midazolam; Nerve Block; Orbit; Oxygen; Partial Pressure; Preanesthetic Medication	1992
Hemodynamic effect of calcium channel blockade during anesthesia for coronary artery surgery. Journal of cardiothoracic and vascular anesthesia, 1992, Volume: 6, Issue:4 Topics: Anesthesia, Intravenous; Blood Pressure; Cardiac Output; Cardiopulmonary Bypass; Coronary Artery Bypass; Coronary Disease; Diltiazem; Double-Blind Method; Droperidol; Fentanyl; Flunitrazepam; Heart Rate; Hemodynamics; Humans; Incidence; Intraoperative Complications; Midazolam; Middle Aged; Placebos; Pulmonary Wedge Pressure; Time Factors; Vascular Resistance	1992
Acute tolerance from benzodiazepine night sedation. Anaesthesia, 1991, Volume: 46, Issue:11 Topics: Adult; Double-Blind Method; Drug Tolerance; Female; Flunitrazepam; Humans; Male; Midazolam; Premedication; Psychomotor Performance; Sleep Stages; Time Factors	1991
Antagonism of benzodiazepine-fentanyl anaesthesia with flumazenil. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1990, Volume: 37, Issue:1 Topics: Adult; Anesthesia, Inhalation; Anti-Anxiety Agents; Double-Blind Method; Female; Fentanyl; Flumazenil; Flunitrazepam; Humans; Male; Midazolam; Middle Aged; Preanesthetic Medication; Randomized Controlled Trials as Topic	1990
[Beta activation following the intravenous administration of benzodiazepines and the specific antagonist flumazenil (Ro 15-1788)]. EEG-EMG Zeitschrift fur Elektroenzephalographie, Elektromyographie und verwandte Gebiete, 1990, Volume: 21, Issue:1 Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Beta Rhythm; Diazepam; Dose-Response Relationship, Drug; Electroencephalography; Flumazenil; Flunitrazepam; Humans; Injections, Intravenous; Lorazepam; Male; Midazolam; Prospective Studies; Randomized Controlled Trials as Topic; Stimulation, Chemical	1990
[Mid-latency auditory evoked potentials during induction of intravenous anesthesia using midazolam, diazepam and flunitrazepam]. Anasthesie, Intensivtherapie, Notfallmedizin, 1990, Volume: 25, Issue:6 Topics: Adult; Anesthesia, Intravenous; Diazepam; Evoked Potentials, Auditory; Female; Flunitrazepam; Genitalia, Female; Humans; Midazolam; Middle Aged; Minor Surgical Procedures; Reaction Time	1990
[Hemodynamic effects of an etomidate-flunitrazepam or midazolam- fentanyl combination for induction of anesthesia in patients with heart valve diseases]. Anasthesie, Intensivtherapie, Notfallmedizin, 1985, Volume: 20, Issue:4 Topics: Adolescent; Adult; Aged; Anesthetics; Benzodiazepines; Blood Pressure; Cardiac Output; Drug Combinations; Etomidate; Female; Fentanyl; Flunitrazepam; Heart Rate; Heart Valve Diseases; Hemodynamics; Humans; Hypertension, Pulmonary; Male; Midazolam; Middle Aged; Preanesthetic Medication	1985
Saccadic eye movements in determination of the residual effects of the benzodiazepines. International journal of clinical pharmacology, therapy, and toxicology, 1986, Volume: 24, Issue:5 Topics: Benzodiazepines; Eye Movements; Flunitrazepam; Humans; Hypnotics and Sedatives; Lorazepam; Midazolam; Placebos; Saccades; Sleep; Time Factors	1986
[Oral premedication before ENT interventions with local anesthesia. Effect profile of midazolam, flunitrazepam and morphine sulfate in comparison with placebo]. Fortschritte der Medizin, 1988, Apr-30, Volume: 106, Issue:13 Topics: Administration, Oral; Adult; Aged; Anesthesia, Local; Clinical Trials as Topic; Double-Blind Method; Flunitrazepam; Humans; Midazolam; Middle Aged; Morphine; Preanesthetic Medication; Random Allocation; Tonsillectomy	1988
Diazepam, flunitrazepam and midazolam for elective endoscopy--a comparative study. Middle East journal of anaesthesiology, 1988, Volume: 9, Issue:6 Topics: Adult; Anxiety; Clinical Trials as Topic; Diazepam; Female; Flunitrazepam; Gastroscopy; Humans; Infusions, Intravenous; Male; Memory; Midazolam; Random Allocation	1988
[Clinical evaluation of flumazenil (Anexate) on the recovery parameters following the administration of 3 benzodiazepines (flunitrazepam, midazolam or diazepam]. Cahiers d'anesthesiologie, 1987, Volume: 35, Issue:8 Topics: Adult; Aged; Analgesics; Anesthesia Recovery Period; Anesthesia, General; Benzodiazepines; Diazepam; Drug Evaluation; Female; Flumazenil; Flunitrazepam; Humans; Male; Midazolam; Middle Aged; Postoperative Period; Prospective Studies; Random Allocation; Respiration	1987
[Midazolam used for premedication reinforces sleep induced by flunitrazepam]. Annales francaises d'anesthesie et de reanimation, 1987, Volume: 6, Issue:5 Topics: Adult; Anesthesia Recovery Period; Clinical Trials as Topic; Drug Interactions; Female; Flunitrazepam; Humans; Male; Midazolam; Middle Aged; Preanesthetic Medication; Sleep	1987
Comparative haemodynamic and respiratory effects of midazolam and flunitrazepam as induction agents in cardiac surgery. Arzneimittel-Forschung, 1981, Volume: 31, Issue:12a Topics: Adult; Aged; Anesthetics; Anti-Anxiety Agents; Benzodiazepines; Blood Gas Analysis; Cardiac Surgical Procedures; Female; Flunitrazepam; Hemodynamics; Humans; Male; Midazolam; Middle Aged; Respiration	1981
Comparison of midazolam and flunitrazepam for night sedation. A randomised double-blind study. Anaesthesia, 1982, Volume: 37, Issue:9 Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Double-Blind Method; Flunitrazepam; Hemodynamics; Humans; Hypnotics and Sedatives; Midazolam; Preanesthetic Medication; Random Allocation; Time Factors	1982
Effect of midazolam, flunitrazepam, and placebo against midwinter insomnia in northern Norway. Acta psychiatrica Scandinavica, 1983, Volume: 67, Issue:2 Topics: Adolescent; Adult; Anti-Anxiety Agents; Benzodiazepines; Double-Blind Method; Female; Flunitrazepam; Humans; Male; Midazolam; Middle Aged; Norway; Seasons; Sleep Initiation and Maintenance Disorders; Sleep Stages	1983
[Hemodynamic effects of midazolam and flunitrazepam used as induction agents in cardiac patients]. Annales francaises d'anesthesie et de reanimation, 1982, Volume: 1, Issue:4 Topics: Adult; Anesthesia, Intravenous; Anesthetics; Anti-Anxiety Agents; Benzodiazepines; Cardiac Catheterization; Female; Flunitrazepam; Heart Diseases; Hemodynamics; Humans; Male; Midazolam; Middle Aged; Respiration	1982
[Comparative hemodynamic effects of midazolam and flunitrazepam in head injury patients under controlled ventilation]. Annales francaises d'anesthesie et de reanimation, 1984, Volume: 3, Issue:3 Topics: Adult; Benzodiazepines; Brain Injuries; Female; Flunitrazepam; Hemodynamics; Humans; Male; Midazolam; Respiration, Artificial	1984
[Comparison of midazolam and flunitrazepam as premedication administered rectally in infants]. Annales francaises d'anesthesie et de reanimation, 1984, Volume: 3, Issue:3 Topics: Age Factors; Anesthesia, Rectal; Anesthetics; Benzodiazepines; Flunitrazepam; Humans; Infant; Midazolam	1984
[The effect of flumazenil in reversing midazolam, flunitrazepam or diazepam]. Masui. The Japanese journal of anesthesiology, 1995, Volume: 44, Issue:6 Topics: Adolescent; Adult; Anesthesia Recovery Period; Anesthesia, Epidural; Anesthesia, Spinal; Diazepam; Female; Flumazenil; Flunitrazepam; Hemodynamics; Humans; Male; Midazolam; Middle Aged; Respiration	1995
Testing the effects of hypnotics on memory via the telephone: fact or fiction? Psychopharmacology, 1993, Volume: 111, Issue:2 Topics: Adult; Double-Blind Method; Female; Flunitrazepam; Humans; Hypnotics and Sedatives; Male; Memory; Memory, Short-Term; Mental Processes; Midazolam; Middle Aged; Neuropsychological Tests; Sleep; Speech; Telephone	1993
Effects of benzodiazepines on mid-latency auditory evoked potentials. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1993, Volume: 40, Issue:12 Topics: Acoustic Stimulation; Adult; Anesthesia, Intravenous; Auditory Cortex; Awareness; Diazepam; Evoked Potentials, Auditory; Evoked Potentials, Auditory, Brain Stem; Female; Flunitrazepam; Humans; Midazolam; Middle Aged; Reaction Time; Reflex, Acoustic	1993
Midazolam and flunitrazepam: pharmacokinetics and effects on night time respiration and body movements in the elderly. International journal of clinical pharmacology, therapy, and toxicology, 1993, Volume: 31, Issue:4 Topics: Age Factors; Aged; Ballistocardiography; Double-Blind Method; Female; Flunitrazepam; Humans; Male; Midazolam; Movement; Respiration; Sleep	1993
Pain following intravenous administration of sedative agents: a comparison of propofol with three benzodiazepines. Anesthesia progress, 1998,Winter, Volume: 45, Issue:1 Topics: Adult; Analysis of Variance; Anesthetics, Intravenous; Anesthetics, Local; Anti-Anxiety Agents; Cross-Over Studies; Diazepam; Double-Blind Method; Drug Combinations; Female; Flunitrazepam; Humans; Injections, Intravenous; Lidocaine; Male; Midazolam; Pain; Pain Measurement; Propofol; Prospective Studies	1998

Other Studies

52 other study(ies) available for flunitrazepam and midazolam

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate. Bioorganic & medicinal chemistry letters, 2010, Dec-15, Volume: 20, Issue:24 Topics: Central Nervous System Agents; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Solubility	2010
Suppressant effects of midazolam on responses of spinal dorsal horn neurones in rabbits. Neuropharmacology, 1992, Volume: 31, Issue:1 Topics: Animals; Bradykinin; Decerebrate State; Flunitrazepam; Microelectrodes; Midazolam; Naloxone; Neurons; Pain; Rabbits; Spinal Cord	1992
Comparison of the relaxant effects of diazepam, flunitrazepam and midazolam on airway smooth muscle. British journal of anaesthesia, 1992, Volume: 69, Issue:1 Topics: Animals; Atropine; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug; Flunitrazepam; Guinea Pigs; Male; Midazolam; Muscle Relaxation; Muscle, Smooth; Propranolol; Trachea	1992
Benzodiazepines do not potentiate GABA responses in neonatal hippocampal neurons. Neuroscience letters, 1991, Sep-16, Volume: 130, Issue:2 Topics: Animals; Animals, Newborn; Drug Interactions; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Iontophoresis; Male; Midazolam; Neurons; Pentobarbital; Rats; Rats, Inbred Strains	1991
[Premedication and analgesic dose procedures in dental medicine]. Zahnarztliche Praxis, 1991, Jul-12, Volume: 42, Issue:7 Topics: Anesthesia, Dental; Anesthesia, Local; Buprenorphine; Clorazepate Dipotassium; Diazepam; Flunitrazepam; Humans; Lorazepam; Meperidine; Midazolam; Morphine; Oxazepam; Pain; Pentazocine; Pirinitramide; Preanesthetic Medication	1991
Pharmacological actions of central nervous system depressants given intravenously as suspensions. Journal of pharmaceutical sciences, 1990, Volume: 79, Issue:12 Topics: Animals; Central Nervous System Depressants; Cerebral Cortex; Electroencephalography; Female; Flunitrazepam; Injections, Intravenous; Male; Methohexital; Midazolam; Rabbits; Suspensions	1990
1,4-Benzodiazepines antagonize opiate-induced antinociception in mice. Anesthesia and analgesia, 1990, Volume: 71, Issue:3 Topics: Analgesia; Animals; Buprenorphine; Diazepam; Dose-Response Relationship, Drug; Fentanyl; Flunitrazepam; Male; Mice; Midazolam; Morphine; Narcotic Antagonists; Psychomotor Performance	1990
Benzodiazepines and the mammalian retina. I. Autoradiographic localisation of receptor sites and the lack of effect on the electroretinogram. Brain research, 1989, Feb-13, Volume: 479, Issue:2 Topics: Animals; Benzodiazepines; Body Weight; Cats; Flumazenil; Flunitrazepam; Flurazepam; Membrane Potentials; Midazolam; Photic Stimulation; Rats; Receptors, GABA-A; Retina	1989
Drug interactions and clinical pharmacokinetics of flumazenil. European journal of anaesthesiology. Supplement, 1988, Volume: 2 Topics: Anti-Anxiety Agents; Benzodiazepines; Biological Availability; Drug Interactions; Ethanol; Flumazenil; Flunitrazepam; Half-Life; Humans; Liver; Lorazepam; Midazolam; Receptors, GABA-A; Tomography, Emission-Computed	1988
Distribution, mobility, and function of benzodiazepine receptors on primary cultures of vertebrate neurons. Advances in biochemical psychopharmacology, 1988, Volume: 45 Topics: Animals; Cells, Cultured; Chick Embryo; Flunitrazepam; Fluorescent Dyes; Midazolam; Neurons; Receptors, GABA-A; Sodium Channels	1988
The effects of benzodiazepines as anaesthesia inducing agents on plasma cortisol level in elective hysterectomy. Acta medica Hungarica, 1985, Volume: 42, Issue:3-4 Topics: Adjuvants, Anesthesia; Adult; Analysis of Variance; Anesthesia, General; Benzodiazepines; Blood Pressure; Diazepam; Female; Flunitrazepam; Humans; Hydrocortisone; Hysterectomy; Midazolam; Middle Aged; Pulse; Stress, Physiological	1985
Benzodiazepine interactions with central thyroid-releasing hormone binding sites: characterization and physiological significance. The Journal of pharmacology and experimental therapeutics, 1986, Volume: 238, Issue:1 Topics: Amygdala; Animals; Benzodiazepines; Brain; Cerebral Cortex; Chlordiazepoxide; Corpus Striatum; Cyclic GMP; Flunitrazepam; Kinetics; Male; Membranes; Midazolam; Pentobarbital; Pyrazoles; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Thyrotropin-Releasing Hormone; Sleep; Thiazolidines; Thyrotropin; Thyrotropin-Releasing Hormone	1986
[Extracorporeal shockwave lithotripsy in sedation-analgesia]. Der Urologe. Ausg. A, 1988, Volume: 27, Issue:2 Topics: Anesthesia, Conduction; Drug Therapy, Combination; Female; Flunitrazepam; Hemodynamics; Humans; Hypnotics and Sedatives; Kidney Calculi; Lithotripsy; Male; Midazolam; Middle Aged; Oxygen; Pirinitramide	1988
[Comparative hemodynamic effects of midazolam and flunitrazepam as induction agents]. [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 1988, Volume: 63, Issue:2 Topics: Adjuvants, Anesthesia; Aged; Flunitrazepam; Hemodynamics; Humans; Male; Midazolam; Middle Aged	1988
Sedatives in regional anesthesia. Acta anaesthesiologica Belgica, 1987, Volume: 38, Issue:3 Suppl 1 Topics: Adjuvants, Anesthesia; Adult; Anesthesia, Conduction; Droperidol; Drug Synergism; Fentanyl; Flunitrazepam; Humans; Midazolam; Middle Aged; Time Factors	1987
A comparison of the antifibrillatory effect of midazolam and flunitrazepam in acute myocardial ischaemia in the dog. Current medical research and opinion, 1987, Volume: 10, Issue:8 Topics: Animals; Anti-Arrhythmia Agents; Coronary Vessels; Dogs; Flunitrazepam; Heart Ventricles; Ligation; Male; Midazolam; Myocardial Infarction	1987
Hemodynamic effects of diazepam, flunitrazepam, and midazolam in patients with ischemic heart disease: assessment with a radionuclide approach. Anesthesiology, 1986, Volume: 65, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Coronary Disease; Coronary Vessels; Diazepam; Flunitrazepam; Hemodynamics; Humans; Midazolam; Middle Aged; Radionuclide Imaging; Stroke Volume	1986
Specific 3H-DMCM binding to a non-benzodiazepine binding site after silver ion treatment of rat brain membranes. Life sciences, 1984, Nov-26, Volume: 35, Issue:22 Topics: Animals; Benzodiazepines; Binding Sites; Binding, Competitive; Brain; Carbolines; Flunitrazepam; In Vitro Techniques; Indoles; Membranes; Midazolam; Nerve Tissue Proteins; Protein Binding; Rats; Receptors, GABA-A; Silver	1984
[Clinical pharmacokinetics of midazolam, flunitrazepam and diazepam (author's transl)]. Anasthesie, Intensivtherapie, Notfallmedizin, 1981, Volume: 16, Issue:3 Topics: Anti-Anxiety Agents; Benzodiazepines; Biotransformation; Diazepam; Dose-Response Relationship, Drug; Flunitrazepam; Humans; Metabolic Clearance Rate; Midazolam; Protein Binding; Tissue Distribution	1981
Effects of oral and intravenous midazolam, triazolam and flunitrazepam on the sleep-wakefulness cycle of rabbits. British journal of clinical pharmacology, 1983, Volume: 16 Suppl 1 Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Benzodiazepines; Electroencephalography; Electromyography; Flunitrazepam; Injections, Intravenous; Male; Midazolam; Rabbits; Sleep; Sleep, REM; Triazolam; Wakefulness	1983
Pharmacokinetics of benzodiazepines: metabolic pathways and plasma level profiles. Current medical research and opinion, 1984, Volume: 8 Suppl 4 Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Bromazepam; Child; Clobazam; Flunitrazepam; Flurazepam; Humans; Hydroxylation; Kinetics; Lorazepam; Midazolam; Middle Aged; Nitrazepam; Nordazepam	1984
Ambulatory motor activity monitoring to study the timecourse of hypnotic action. British journal of clinical pharmacology, 1984, Volume: 18 Suppl 1 Topics: Anti-Anxiety Agents; Benzodiazepines; Flunitrazepam; Flurazepam; Humans; Hypnotics and Sedatives; Midazolam; Motor Activity; Sleep; Temazepam; Time Factors; Triazolam	1984
[Induction of anesthesia with midazolam, with special consideration of the effect on the systolic time interval]. Arzneimittel-Forschung, 1981, Volume: 31, Issue:12a Topics: Anesthetics; Benzodiazepines; Blood Pressure; Flunitrazepam; Humans; Midazolam; Myocardial Contraction; Preanesthetic Medication; Respiration; Systole; Time Factors	1981
[Midazolam for premedication in children]. Cahiers d'anesthesiologie, 1995, Volume: 43, Issue:2 Topics: Administration, Intranasal; Administration, Oral; Administration, Rectal; Anesthetics; Child; Child, Preschool; Diazepam; Flunitrazepam; Humans; Infant; Injections, Intramuscular; Injections, Intravenous; Ketamine; Midazolam; Preanesthetic Medication	1995
Effects of intravenous anaesthetics on function and metabolism in the isolated rat heart-lung preparation. European journal of anaesthesiology, 1994, Volume: 11, Issue:3 Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Anesthesia, Intravenous; Animals; Atrial Function, Right; Blood Pressure; Cardiac Output; Diazepam; Flunitrazepam; Heart; Heart Rate; Ketamine; Lung; Male; Midazolam; Myocardium; Rats; Rats, Wistar; Ventricular Function, Left; Ventricular Pressure	1994
Reduction of dopamine release and postoperative emesis by benzodiazepines. British journal of anaesthesia, 1993, Volume: 71, Issue:2 Topics: Animals; Dopamine; Flunitrazepam; Midazolam; Postoperative Complications; Rats; Vomiting	1993
Effects of midazolam and flunitrazepam on the release of dopamine from rat striatum measured by in vivo microdialysis. British journal of anaesthesia, 1993, Volume: 70, Issue:2 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dialysis; Dopamine; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; Homovanillic Acid; Male; Midazolam; Rats; Rats, Sprague-Dawley; Substantia Nigra	1993
Mechanism-based modeling of functional adaptation upon chronic treatment with midazolam. Pharmaceutical research, 2000, Volume: 17, Issue:3 Topics: Adaptation, Physiological; Animals; Biological Transport; Brain Chemistry; Chlorine; Dose-Response Relationship, Drug; Electroencephalography; Flunitrazepam; GABA Agonists; GABA Modulators; Male; Midazolam; Models, Biological; Muscimol; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A; Tritium	2000
[The effect of midazolam and flunitrazepam on the liberation of lysozyme and beta-glucuronidase from neutrophil granulocytes in vitro]. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 2000, Volume: 35, Issue:5 Topics: Anesthetics, Intravenous; Flunitrazepam; GABA Modulators; Glucuronidase; Humans; In Vitro Techniques; Male; Midazolam; Muramidase; Neutrophils; Stimulation, Chemical	2000
Stability of benzodiazepines in whole blood samples stored at varying temperatures. Journal of pharmaceutical and biomedical analysis, 2000, Volume: 23, Issue:6 Topics: Anti-Anxiety Agents; Chromatography, High Pressure Liquid; Clonazepam; Drug Stability; Flunitrazepam; Forensic Medicine; Humans; Midazolam; Oxazepam; Temperature; Time Factors	2000
Tolerance to midazolam's anxiolytic effects after short-term nicotine treatment. Neuropharmacology, 2001, Volume: 40, Issue:5 Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Binding, Competitive; Drug Tolerance; Environment; Flunitrazepam; Hippocampus; Injections, Subcutaneous; Interpersonal Relations; Male; Microinjections; Midazolam; Nicotine; Nicotinic Agonists; Raphe Nuclei; Rats; Receptors, GABA-A	2001
High-dose midazolam and the attenuation of the contractile response to vasoconstrictors in coronary artery segments. European journal of anaesthesiology, 2003, Volume: 20, Issue:4 Topics: Animals; Anti-Anxiety Agents; Diazepam; Dose-Response Relationship, Drug; Endothelium, Vascular; Flunitrazepam; Histamine; Hypnotics and Sedatives; In Vitro Techniques; Midazolam; Muscle Contraction; Muscle, Smooth, Vascular; Rats; Serotonin; Vasoconstrictor Agents	2003
A sensitive HPLC-MS-MS assay for quantitative determination of midazolam in dog plasma. Journal of pharmaceutical and biomedical analysis, 2004, Apr-01, Volume: 35, Issue:1 Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Area Under Curve; Calibration; Chromatography, High Pressure Liquid; Dogs; Flunitrazepam; Injections, Intravenous; Male; Mass Spectrometry; Midazolam; Reference Standards; Reproducibility of Results; Sensitivity and Specificity	2004
Characterization of a new synthetic isoflavonoid with inverse agonist activity at the central benzodiazepine receptor. European journal of pharmacology, 2004, Jul-14, Volume: 495, Issue:2-3 Topics: Analysis of Variance; Animals; Bicuculline; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Female; Flavonoids; Flunitrazepam; GABA Agonists; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Hippocampus; Isoflavones; Kinetics; Male; Membrane Potentials; Midazolam; Neurons; Pregnancy; Rats; Rats, Wistar; Receptors, GABA-A; Synaptosomes; Time Factors; Tritium	2004
Evidence of significant contribution from CYP3A5 to hepatic drug metabolism. Drug metabolism and disposition: the biological fate of chemicals, 2004, Volume: 32, Issue:12 Topics: Animals; Antifungal Agents; Baculoviridae; Biotransformation; Cell Line; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochromes b5; Flunitrazepam; Humans; In Vitro Techniques; Insecta; Isoenzymes; Itraconazole; Kinetics; Liver; Microsomes, Liver; Midazolam; Pharmaceutical Preparations	2004
Quantification of benzodiazepines in whole blood and serum. International journal of legal medicine, 2006, Volume: 120, Issue:6 Topics: Anti-Anxiety Agents; Benzodiazepines; Chromatography, High Pressure Liquid; Flunitrazepam; Flurazepam; Forensic Toxicology; Humans; Mass Spectrometry; Midazolam; Molecular Structure; Serum	2006
Intravenous infusion of midazolam and flunitrazepam for insomnia on Japanese palliative care units. Journal of pain and symptom management, 2005, Volume: 30, Issue:4 Topics: Anti-Anxiety Agents; Flunitrazepam; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Japan; Midazolam; Palliative Care; Sleep Initiation and Maintenance Disorders	2005
CNS 7056: a novel ultra-short-acting Benzodiazepine. Anesthesiology, 2007, Volume: 107, Issue:1 Topics: Animals; Benzodiazepines; Binding, Competitive; Cell Line; Cerebral Cortex; Electrophysiology; Extracellular Space; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Hypnotics and Sedatives; In Vitro Techniques; Ion Channels; Membranes; Mice; Midazolam; Postural Balance; Radioligand Assay; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, GABA-A; Substantia Nigra; Swine; Swine, Miniature; Transfection	2007
Efficacy, safety, and cost effectiveness of intravenous midazolam and flunitrazepam for primary insomnia in terminally ill patients with cancer: a retrospective multicenter audit study. Journal of palliative medicine, 2007, Volume: 10, Issue:5 Topics: Aged; Anti-Anxiety Agents; Cost-Benefit Analysis; Female; Flunitrazepam; Humans; Japan; Male; Medical Audit; Midazolam; Neoplasms; Palliative Care; Retrospective Studies; Sleep Initiation and Maintenance Disorders; Terminally Ill	2007
Prediction of metabolic clearance using fresh human hepatocytes: comparison with cryopreserved hepatocytes and hepatic microsomes for five benzodiazepines. Xenobiotica; the fate of foreign compounds in biological systems, 2008, Volume: 38, Issue:4 Topics: Alprazolam; Benzodiazepines; Cell Survival; Cells, Cultured; Cryopreservation; Cytochrome P-450 CYP3A; Diazepam; Flunitrazepam; Hepatocytes; Humans; Metabolic Clearance Rate; Microsomes, Liver; Midazolam; Substrate Specificity; Triazolam	2008
Impact of the use of propofol remifentanil goal-directed sedation adapted by nurses on the time to extubation in mechanically ventilated ICU patients: the experience of a French ICU. Annales francaises d'anesthesie et de reanimation, 2008, Volume: 27, Issue:6 Topics: Anesthetics, Intravenous; Flunitrazepam; France; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Intensive Care Units; Midazolam; Pain Measurement; Piperidines; Propofol; Remifentanil; Respiration, Artificial; Survival Rate; Treatment Outcome	2008
Selective changes in sensitivity to benzodiazepines, and not other positive GABA(A) modulators, in rats receiving flunitrazepam chronically. Psychopharmacology, 2009, Volume: 204, Issue:4 Topics: Animals; Benzodiazepines; Binding Sites; Dose-Response Relationship, Drug; Drug Tolerance; Flunitrazepam; Ketamine; Male; Midazolam; Morphine; Pentobarbital; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reinforcement Schedule; Substance-Related Disorders	2009
The effects of benzodiazepines on urotensin II-stimulated norepinephrine release from rat cerebrocortical slices. Anesthesia and analgesia, 2009, Volume: 108, Issue:4 Topics: Animals; Benzodiazepines; Benzoxazoles; Calcium Signaling; Cell Line; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; GABA-A Receptor Agonists; Humans; Hypnotics and Sedatives; In Vitro Techniques; Male; Midazolam; Naphthyridines; Norepinephrine; Orexin Receptors; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, GABA-A; Receptors, Neuropeptide; Transfection; Urea; Urotensins	2009
Simultaneous determination and quantification of 12 benzodiazepines in serum or whole blood using UPLC/MS/MS. Methods in molecular biology (Clifton, N.J.), 2010, Volume: 603 Topics: Alprazolam; Benzodiazepines; Chlordiazepoxide; Chromatography, Liquid; Clonazepam; Flunitrazepam; Humans; Lorazepam; Midazolam; Nordazepam; Oxazepam; Reproducibility of Results; Tandem Mass Spectrometry	2010
Comparing the discriminative stimuli produced by either the neuroactive steroid pregnanolone or the benzodiazepine midazolam in rats. Psychopharmacology, 2011, Volume: 214, Issue:2 Topics: Animals; Behavior, Animal; Discrimination, Psychological; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; GABA Modulators; Male; Midazolam; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A	2011
Quantitative analyses of antagonism: combinations of midazolam and either flunitrazepam or pregnanolone in rhesus monkeys discriminating midazolam. The Journal of pharmacology and experimental therapeutics, 2012, Volume: 340, Issue:3 Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Female; Flumazenil; Flunitrazepam; Macaca mulatta; Midazolam; Pregnanolone; Receptors, GABA-A	2012
Discriminative stimulus effects of pregnanolone in rhesus monkeys. Psychopharmacology, 2014, Volume: 231, Issue:1 Topics: Animals; Conditioning, Operant; Data Interpretation, Statistical; Discrimination, Psychological; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Flumazenil; Flunitrazepam; GABA Modulators; Gonadal Steroid Hormones; Hypnotics and Sedatives; Isoxazoles; Macaca mulatta; Male; Midazolam; Pregnanolone; Receptors, GABA-A; Reinforcement Schedule	2014
Single-Dose Subcutaneous Benzodiazepines for Insomnia in Patients With Advanced Cancer. Journal of pain and symptom management, 2015, Volume: 49, Issue:6 Topics: Aged; Aged, 80 and over; Drug Administration Schedule; Female; Flunitrazepam; Humans; Hypnotics and Sedatives; Injections, Subcutaneous; Male; Midazolam; Middle Aged; Neoplasms; Sleep Initiation and Maintenance Disorders; Treatment Outcome	2015
Use of GABAergic sedatives after subarachnoid hemorrhage is associated with worse outcome-preliminary findings. Journal of clinical anesthesia, 2016, Volume: 35 Topics: Adult; Aged; Brain; Conscious Sedation; Female; Flunitrazepam; GABA Modulators; Glasgow Coma Scale; Humans; Hypnotics and Sedatives; Male; Midazolam; Middle Aged; Propofol; Regeneration; Retrospective Studies; Subarachnoid Hemorrhage	2016