flunitrazepam has been researched along with gamma-aminobutyric acid in 400 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 209 (52.25) | 18.7374 |
| 1990's | 139 (34.75) | 18.2507 |
| 2000's | 45 (11.25) | 29.6817 |
| 2010's | 5 (1.25) | 24.3611 |
| 2020's | 2 (0.50) | 2.80 |
| Authors | Studies |
|---|---|
| Chou, WH; McMahon, T; Messing, RO; Newton, PM; Qi, ZH; Shokat, KM; Song, M; Wallace, MJ; Wang, D; Zhang, C | 1 |
| Reisine, TD; Speth, RC; Wastek, GJ; Yamamura, HI | 1 |
| Dudai, Y | 1 |
| Karobath, M; Placheta, P | 1 |
| Kuhar, MJ; Niehoff, DL; Palacios, JM | 1 |
| Baraldi, M; Costa, E; Guidotti, A; Schwartz, JP | 1 |
| Chang, RS; Gavish, M; Snyder, SH | 1 |
| Karobath, M; Lippitsch, M | 1 |
| Beer, B; Benson, DI; Klepner, CA; Lippa, AS; Sano, MC | 1 |
| Cano, J; Machado, A; Ruano, D; Vitorica, J; Vizuete, M | 1 |
| Prince, RJ; Simmonds, MA | 1 |
| Uusi-Oukari, M | 1 |
| Mehta, AK; Ticku, MK | 3 |
| Farb, DH; Friedman, L; Gibbs, TT; Gyenes, M; Russek, SJ; Wu, FS | 1 |
| Hales, TG; Kim, H; Longoni, B; Olsen, RW; Tobin, AJ | 1 |
| Bowers, BJ; Wehner, JM | 1 |
| Dodd, PR; Harper, CG; Kril, JJ; Thomas, GJ | 1 |
| Kuriyama, K; Ueha, T | 1 |
| Debilly, G; Deluermoz, S; Kopp, N; Miachon, S; Rochet, T; Vedrinne, J | 1 |
| Bao, J; Lee, YH; Tang, XW; Tsai, WH; Wu, E; Wu, JY; Yarom, M | 1 |
| Carter, DB; Gale, W; Im, HK; Im, WB; Lennon, DJ; Ngo, DM; Seeburg, PH; Smith, MW; Thomsen, DR | 1 |
| Miller, CL; Quinn, MR | 1 |
| Calvo, P; Chinchetru, MA; Fernández-López, A; Negro, M | 1 |
| Cecchi, L; Colotta, V; Filacchioni, G; Gelli, S; Lucacchini, A; Martini, C; Melani, F | 2 |
| Allan, AM; Draski, LJ; Mayes, GG | 1 |
| Daval, JL; Werck, MC | 1 |
| Barnes, EM; Tehrani, MH | 3 |
| Daval, JL; Nehlig, A; Pereira de Vasconcelos, A; Werck, MC | 1 |
| Drescher, U; Kellenberger, S; Knoflach, F; Malherbe, P; Möhler, H; Rhyner, T; Sigel, E; Villa, M | 1 |
| Biggio, G; Concas, A; Gessa, GL; Peduto, VA; Santoro, G | 1 |
| Dawson, RM; Poretski, M | 1 |
| Chen, JP; Lal, H; Martin, MW; Prather, PL; Rezazadeh, SM | 1 |
| Lummis, SC; Rauh, JJ; Sattelle, DB; Wong, JF | 1 |
| Bacon, E; de Barry, J; Girard, C; Gombos, G | 1 |
| Ewert, M; Kettenmann, H; Kleingoor, C; Seeburg, PH; von Blankenfeld, G | 1 |
| Fernandes, G; Mhatre, MC; Ticku, MK | 1 |
| Scarth, BA; Shaw, C | 1 |
| Airaksinen, MM; MacDonald, E; Rägo, L; Saano, V | 1 |
| Harris, RA; McQuilkin, SJ | 1 |
| Farb, DH; Friedman, L; Gibbs, TT; Roca, DJ; Rozenberg, I; Schiller, GD | 1 |
| Kellogg, CK; Primus, RJ | 1 |
| Ben-Ari, Y; Rovira, C | 1 |
| Deng, L; Nielsen, M; Olsen, RW | 1 |
| Cano, J; Machado, A; Ruano, D; Vitorica, J | 1 |
| Burt, DR; Huganir, RL; Kofuji, P; Mei, L; Moss, SJ; Ravindran, A; Wang, JB | 1 |
| Dragunow, M; Faull, RL; Jansen, KL; Mohler, H; Richards, JG; Streit, P; Waldvogel, HJ | 1 |
| Ge, LJ; Kastin, AJ; Zadina, JE | 1 |
| Albers, HE; Liou, SY; Shibata, S; Ueki, S | 1 |
| Arce, A; Perillo, MA | 1 |
| Córdoba, C; Fernández, I; Orensanz, LM | 1 |
| Farb, DH; Farrant, M; Roca, DJ; Rozenberg, I | 1 |
| Adojaan, A; Allikmets, L; Harro, J; Kiivet, RA; Rägo, L | 1 |
| Costa, E; Paul, SM; Pritchett, DB; Puia, G; Purdy, RH; Santi, MR; Seeburg, PH; Vicini, S | 1 |
| Borden, LA; Gibbs, TT | 1 |
| Kulkarni, SK; Ticku, MK | 1 |
| Danielou, G; Lloyd, GK; Thuret, F | 1 |
| Ferraro, D; Guarneri, R; La Bella, V; Piccoli, F; Salemi, G; Savettieri, G; Scondotto, S | 1 |
| Boyce, S; Clarke, CA; Crossman, AR; Robertson, RG; Sambrook, MA | 1 |
| Garattini, S; Gobbi, M; Mennini, T; Ponzio, F | 1 |
| Costa, E; Mienville, JM; Vicini, S | 1 |
| Havoundjian, H; Skolnick, P; Trullas, R | 1 |
| Barnard, EA; Bilbe, G; Houamed, K; Moss, SJ; Smart, TG; Van Renterghem, C | 1 |
| David, JA; Pinnock, RD; Sattelle, DB; Wafford, KA | 1 |
| McIntyre, TD; Skolnick, P; Trullas, R | 1 |
| Evoniuk, G; Skolnick, P | 1 |
| Chiu, TH; Rosenberg, HC; Tietz, EI | 1 |
| Marczynski, TJ; Urbancic, M | 1 |
| Besson, MJ; Caboche, J; Le Saux, F; Maurin, Y; Mitrovic, N; Sauter, A | 1 |
| De Robertis, E; de Stein, ML; Medina, JH | 1 |
| Biggio, G; Cau, A; Corda, MG; Laudani, U; Longoni, B; Paci, S; Salvadori, S | 1 |
| Evoniuk, G; Moody, EJ; Skolnick, P | 1 |
| Lehoullier, PF; Ticku, MK | 1 |
| Ebner, J; Ferenci, P; Zimmermann, C | 1 |
| Blakeman, DP; Davis, JP; Im, WB; Tai, MM | 1 |
| Hebebrand, J; Reichelt, R; Schmitz, E | 1 |
| Harro, J; Kiivet, RA; Pŏld, M; Rägo, L | 1 |
| Bowen, DM; Cross, AJ; Francis, PT; Green, AR; Robinson, TN; Stirling, JM | 1 |
| Barnes, EM; Hablitz, JJ; Tehrani, MH | 1 |
| Bristow, DR; Martin, IL | 2 |
| Bechtel, WD; Ikeda, M; Malatynska, E; Weber, KH; Yamamura, HI | 1 |
| Machen, VL; Swaiman, KF | 1 |
| Friedl, W; Hebebrand, J; Hewing, M; Kessler, K; Propping, P | 1 |
| Cross, JA; Horton, RW; Kimber, JR | 1 |
| Barnett, A; Biggio, G; Corda, MG; Giorgi, O; Longoni, B; Montaldo, S; Ongini, E | 1 |
| Gossuin, A; Laterre, C; Maloteaux, JM; Octave, JN; Trouet, A | 1 |
| Cox, DH; Guidotti, A; Santi, MR | 1 |
| McCabe, RT; Olsen, RW; Wamsley, JK; Yezuita, JP | 1 |
| Farb, DH; Roca, DJ; Schiller, GD | 1 |
| Ho, IK; Hoskins, B; Ito, Y; Lim, DK | 1 |
| Collins, AC; Freund, RK; Jungschaffer, DA; Wehner, JM | 1 |
| Cortés, R; Palacios, JM; Probst, A; Zezula, J | 1 |
| Marley, RJ; Stinchcomb, A; Wehner, JM | 1 |
| Lehoullier, P; Mehta, A; Ticku, M | 1 |
| Gobbi, M; Mennini, T; Perin, L; Salmona, M | 1 |
| Chivers, J; Horton, RW; Jenner, P; Lowther, S; Marsden, CD; Testa, B | 1 |
| Block, LD; Guilarte, TR; Wagner, HN | 1 |
| Turský, T | 1 |
| Backus, KH; Kettenmann, H; Schachner, M | 1 |
| Chweh, AY; Swinyard, EA; Wolf, HH | 2 |
| Clow, A; Glover, V; Sandler, M | 1 |
| Goldberg, ME; Malick, JB; Patel, JB; Salama, AI | 1 |
| Boespflug, O; Swaiman, KF | 1 |
| Kishi, M; Kuriyama, K; Mukainaka, T; Ohkuma, S; Tomono, S | 1 |
| Koe, BK; Kondratas, E; Russo, LL | 1 |
| Concas, A; Morelli, M; Obata, T; Serra, M; Yamamura, HI | 1 |
| Gallager, DW; Marley, RJ | 1 |
| Fillenz, M; Fung, SC | 1 |
| Chiu, TH; Rosenberg, HC | 2 |
| Fanelli, RJ; Iadarola, MJ; McNamara, JO; Wilson, WA | 1 |
| Chweh, AY; Kupferberg, HJ; Swinyard, EA; Wolf, HH | 2 |
| Ngo, TT; Tunnicliff, G; Welborn, KL | 1 |
| Crawford, RD; Davis, LG; Fisher, TE; Johnson, DD; Tuchek, JM | 1 |
| Eichinger, A; Sieghart, W | 1 |
| Biziere, K; Brochard, J; Brodin, R; Chambon, JP; Hallot, A; Heaulme, M; Roncucci, R | 1 |
| Awad, M; Fares, F; Gavish, M | 1 |
| Chweh, AY; Swinyard, EA; Ulloque, RA; Wolf, HH | 1 |
| Hornykiewicz, O; Kish, SJ; Perry, TL; Sweeney, VP | 1 |
| Komiskey, HL; Meyers, MB | 1 |
| Allikmets, LH; Harro, JE; Kiivet, RA; Rägo, LK | 1 |
| Hattori, H; Ito, M; Mikawa, H | 1 |
| Haefely, W; Möhler, H; Richards, JG; Schoch, P | 1 |
| Cohen, RM; Havoundjian, H; Paul, SM; Skolnick, P | 1 |
| Mennini, T | 1 |
| Sweetnam, PM; Tallman, JF | 1 |
| Kontro, P; Malminen, O | 1 |
| Havoundjian, H; Paul, SM; Skolnick, P | 1 |
| Chiu, TH; Ito, M; Rosenberg, HC | 1 |
| Garrett, KM; Tabakoff, B | 1 |
| Hammond, JR; Martin, IL | 2 |
| Chang, LR; Lee, HK; Tao, PL | 1 |
| Dawson, RM | 1 |
| Marley, RJ; Wehner, JM | 2 |
| Alho, H; Guidotti, A; Santi, MR; Vaccarino, FM | 1 |
| Beadle, DJ; Benson, JA; Lees, G; Neumann, R | 1 |
| Breidenbach, B; Friedl, W; Hebebrand, J; Propping, P | 1 |
| Havoundjian, H; Paul, S; Skolnick, P; Trullas, R | 1 |
| Stephenson, FA | 1 |
| Alho, H; Costa, E; Mienville, JM; Santi, MR; Vaccarino, FM; Vicini, S | 1 |
| Crabbe, JC; Feller, DJ; Harris, RA | 1 |
| Charles, AK; Leach, JF | 1 |
| Zarkovsky, AM | 1 |
| Horton, RW; Jenner, P; Marsden, CD; Prestwich, SA; Rupniak, NM | 1 |
| Dalezios, Y; Matsokis, N | 1 |
| Carlin, RK; Siekevitz, P | 1 |
| Hajós, F; Kardos, J; Simonyi, M | 1 |
| Burnham, WM; Kish, SJ; Niznik, HB | 1 |
| Borden, LA; Chan, CY; Czajkowski, C; Farb, DH | 1 |
| Braunwalder, A; Cheney, DL; Loo, P; Wood, PL; Yokoyama, N | 1 |
| Begassat, F; Benavides, J; Camelin, JC; Flamier, A; Gueremy, C; Le Fur, G; Malgouris, C; Quarteronet, D; Tur, C; Uzan, A | 1 |
| Anderson, RA; Mitchell, R | 1 |
| Caputti, E; Cardinali, DP; Lowenstein, PR; Rosenstein, R | 1 |
| Borden, LA; Chan, CY; Czajkowski, CM; Farb, DH; Gibbs, TT; Schiller, GD | 1 |
| Hamon, M; Hery, F; Jobert, A; Montastruc, JL; Soubrie, P; Thiebot, MH | 1 |
| Regan, JW; Roeske, WR; Yamamura, HI | 2 |
| Dudai, Y; Sherman-Gold, R | 3 |
| Gale, K; Iversen, L; Overstreet, D; Reisine, TD; Rossor, M; Yamamura, HI | 1 |
| Hösli, E; Hösli, L; Möhler, H; Richards, JG | 1 |
| Robertson, HA | 1 |
| Drexler, G; Karobath, M; Supavilai, P | 1 |
| Möhler, H; Richards, JG; Wu, JY | 1 |
| Gavish, M; Snyder, SH | 1 |
| Braestrup, C; Ehlert, FJ; Roeske, WR; Yamamura, HI; Yamamura, SH | 1 |
| Dichter, MA; Snodgrass, SR; White, WF | 1 |
| Dehaven, R; Pong, SS; Wang, CC | 1 |
| Bowery, NG; Doble, A; Hill, DR; Hudson, AL; Iversen, LL | 1 |
| Arbilla, S; Bartholini, G; Beaumont, K; Briley, M; De Montis, G; Langer, SZ; Lloyd, KG; Scatton, B | 1 |
| Meiners, BA; Salama, AI | 1 |
| Drexler, G; Karobath, M; Sieghart, W; Supavilai, P | 1 |
| Gallager, DW | 1 |
| Collins, JF; Karobath, M; Mannonen, A; Supavilai, P | 1 |
| Chiu, TH; Dryden, DM; Rosenberg, HC | 1 |
| Mählmann, H; Quast, U | 1 |
| Harris, RA; Rohde, BH | 1 |
| Atkinson, DJ; Balázs, R; Brooksbank, BW | 1 |
| Barnes, DM; Dichter, MA; White, WF | 1 |
| Karobath, M; Supavilai, P | 3 |
| Fong, J; Goldstein, M; Lew, JY; Okada, K | 1 |
| Crim, LW; Khan, I; Wilkinson, DA; Wilkinson, M | 1 |
| Gruber, J; Jellinger, K; Rausch, WD; Riederer, P; Rossmanith, W; Weiser, M | 1 |
| Cardinali, DP; Lowenstein, PR | 2 |
| Hornykiewicz, O; Kish, SJ; Perry, TL; Shannak, KS | 1 |
| Keane, PE; Morre, M; Simiand, J | 1 |
| Garattini, S; Gobbi, M; Mennini, T | 1 |
| Head, RA; Tunnicliff, G; Welborn, KL | 1 |
| Colombo, G; Glässer, A; Luzzani, F | 1 |
| Cattabeni, F; Eli, M; Pastorello, MC | 1 |
| Benson, DI; Klepner, CA; Squires, RF | 1 |
| Karobath, M; Sieghart, W | 1 |
| Agnati, LF; Andersson, K; Eneroth, P; Fuxe, K; Karobath, M; Köhler, C; Krogsgaard-Larsen, P; Ogren, SO; Pérez de la Mora, M | 1 |
| Beer, B; Lippa, AS; Meyerson, LR; Sano, MC; Vogel, RA | 1 |
| Deshmukh, P; Regan, JW; Roeske, WR; Ruth, WH; Yamamura, HI | 1 |
| Kuhar, MJ; Niehoff, DL; Palacios, JM; Unnerstall, JR | 1 |
| Asano, T; Ogasawara, N | 4 |
| Ehlert, FJ; Roeske, WR; Yamamura, HI | 1 |
| Kuhar, MJ; Palacios, JM | 1 |
| Fanelli, RJ; McNamara, JO; Valdes, F | 1 |
| Malick, JB; Regan, JW; Roeske, WR; Yamamura, HI; Yamamura, SH | 1 |
| Brundish, DE; Cash, WD; Czernik, AJ; Granat, FR; Kalinsky, HJ; Lovell, RA; Petrack, B; Psychoyos, S; Rinehart, RK; Tsai, C; Wade, R | 1 |
| Biagioni, TM; Volicer, L | 1 |
| Olsen, RW; Stephenson, FA; Watkins, AE | 1 |
| Horst, WD; Kuhar, MJ; Mashal, RD; Niehoff, DL; O'Brien, RA; Palacios, JM | 1 |
| Ho, IK; Sivam, SP | 1 |
| Horton, RW; Meldrum, BS; Prestwich, SA | 1 |
| Gee, KW; Yamamura, HI | 1 |
| Ehlert, FJ; Gee, KW; Yamamura, HI | 2 |
| Gardner, CR; Piper, DC | 1 |
| Barnard, EA; Mamalaki, C; Sigel, E | 1 |
| Penney, JB; Young, AB | 1 |
| Doble, A | 1 |
| Horton, RW; Prestwich, SA; Stapleton, SR | 1 |
| Asano, T; Ogasawara, N; Yamada, Y | 1 |
| Blanchard, JC; Julou, L | 1 |
| Asano, T; Ogasawara, N; Sakakibara, J | 1 |
| Antoniadis, A; Müller, WE; Wollert, U | 1 |
| Brinton, RE; Gee, KW; Yamamura, HI | 1 |
| Barnard, EA; Mamalaki, C; Sigel, E; Stephenson, FA | 1 |
| Fanelli, RJ; McNamara, JO | 1 |
| Becker, JW; Cherwinski, HM; de Blas, AL; Mernoff, ST | 1 |
| Bymaster, FP; Lacefield, WB; Rathbun, RC; Wong, DT | 1 |
| Ehlert, FJ; Gee, KW; Roeske, WR; Yamamura, HI | 1 |
| Lucacchini, A; Martini, C; Rigacci, T | 1 |
| Gavish, M | 1 |
| Mitchell, R; Wilson, LE | 1 |
| Lo, MM; Snyder, SH | 1 |
| Hösli, E; Hösli, L | 1 |
| Mishra, RK; Racine, RJ; Tuff, LP | 1 |
| Quinn, MR; Somerville, RA | 1 |
| Borden, LA; Chan, CY; Farb, DH; Gibbs, TT | 1 |
| Hornykiewicz, O; Kish, SJ; Perry, TL | 1 |
| Cooper, EC; Diamond, I; Gordon, A; Greenberg, DA | 1 |
| Squires, RF | 1 |
| Abbracchio, MP; Balduini, W; Cattabeni, F; Coen, E; Lombardelli, G; Peruzzi, G | 1 |
| Horton, R; Prestwich, S; Sykes, C | 1 |
| Barnard, EA; Sigel, E | 1 |
| Brown, CL; Martin, IL | 1 |
| Jacobson, W; Manchester, EL; Whitaker, KJ; Wilkinson, M | 1 |
| Hamon, M; Jobert, A; Soubrié, P; Thiébot, MH | 1 |
| Kuhar, MJ; Young, WS | 1 |
| Grayson, DR; Harris, BT; Vicini, S; Zhu, WJ | 1 |
| Frandsen, A; Pomés, A; Rodríguez-Farré, E; Sanfeliu, C; Schousboe, A; Suñol, C | 1 |
| Nabeshima, A; Saito, T; Takahata, N; Toki, S | 1 |
| Niles, LP; Tenn, CC | 1 |
| Lillrank, SM; Oja, SS; Saransaari, P | 1 |
| Bormann, J; Feigenspan, A; Wässle, H | 1 |
| Cazin, L; Louiset, E; Vaudry, H | 1 |
| Boksa, P; Chaudieu, I; Quirion, R; St-Pierre, JA | 1 |
| Catarzi, D; Cecchi, L; Colotta, V; Filacchioni, G; Giousti, L; Lucacchini, A; Martini, C; Varano, F | 1 |
| Dalezios, Y; Matsokis, N; Valcana, T | 1 |
| Baldelli, P; Cupello, A; Robello, M | 1 |
| Chen, JS; Gee, KW; Hawkinson, JE; Lan, NC; Liu, V; McCauley, LD | 1 |
| Inglefield, JR; Kellogg, CK; Sieghart, W | 1 |
| Inglefield, JR; Kellogg, CK | 1 |
| Lin, ZS; Yazulla, S | 1 |
| Cancedda, E; Corda, MG; Giorgi, O; Lecca, D; Orlandi, M | 1 |
| Harris, RA; Klein, RL; Whiting, PJ | 1 |
| Belelli, D; Chen, R; Lambert, JJ; Lan, NC; Peters, JA; Reyes, A | 1 |
| Cazin, L; Louiset, E; Mei, YA; Valentijn, JA; Vaudry, H | 1 |
| Albin, RL; Gilman, S; Hollingsworth, Z; Sakurai, SY | 1 |
| Harris, RA; McQuilkin, SJ; Mihic, SJ; Whatley, VJ | 1 |
| Bain, C; Wafford, KA; Whiting, PJ; Wingrove, PB | 1 |
| Corda, MG; Driscoll, P; Escorihuela, RM; Giorgi, O; Lecca, D; Orlandi, M | 1 |
| Reynolds, GP; Stroud, D | 1 |
| Kikuchi de Beltrán, K; Kobayashi, M; Koshikawa, N; Miwa, Y; Stephenson, JD | 1 |
| Davies, MF; Loew, GH; Maguire, PA | 1 |
| Hausman, RE; Shah, BH | 1 |
| Biggio, G; Concas, A; Dazzi, L; Maciocco, E; Mascia, MP; Ongini, E; Santoro, G | 1 |
| Guilarte, TR; Pilachowski, J | 1 |
| Li, TK; Lumeng, L; McBride, WJ; Thielen, RJ | 1 |
| Bosy, TZ; Waltrip, LA; Wehner, JM | 1 |
| Liljequist, S; Tabakoff, B | 1 |
| Hadingham, KL; Harkness, PC; Horne, AL; Kemp, JA; Whiting, P | 1 |
| Drescher, U; Knoflach, F; Malherbe, P; Mohler, H; Scheurer, L | 1 |
| Bureau, MH; Olsen, RW | 1 |
| Calvo, P; Fernández-López, A; Negro, M | 1 |
| Fuchs, K; Sieghart, W; Slany, A; Zezula, J | 1 |
| Biggio, G; Ghiani, CA; Maciocco, E; Sanna, E; Serra, M; Tuligi, G | 1 |
| Bain, C; Garrett, EM; Hadingham, KL; Heavens, RP; Sirinathsinghji, DJ; Wafford, KA; Whiting, PJ | 1 |
| Cassels, BK; Marder, M; Medina, JG; Paladini, AC; Viola, H; Wasowski, C; Waterman, PG; Wolfman, C | 1 |
| File, SE; Hogg, S; Mills, AD | 1 |
| Albin, RL; Caspary, DM; Milbrandt, JC; Turgeon, SM | 1 |
| Crane, DI; Dodd, PR; McCloskey, A; Smith, ID; Thomas, GJ | 1 |
| Bristow, DR; Brown, MJ | 1 |
| Braun, D; Chmielewski, PA; Kane, JM; Miller, JA | 1 |
| Farb, DH; Friedman, LK; Gibbs, TT | 1 |
| Hatta, S; Saito, T; Takahata, N; Toki, S | 1 |
| Araujo, F; Bentareha, R; Ruano, D; Vitorica, J | 1 |
| Dodd, PR; Harper, CG; Johnston, GA; Kril, JJ; Thomas, GJ; Watson, WE | 1 |
| Kivastik, T; Liljequist, S; Pokk, P; Sobol, D; Zharkovsky, A | 1 |
| Fueta, Y; Janjua, NA; Mita, T; Murai, Y; Ohmori, O; Ohno, K; Ono, T | 1 |
| Davies, PA; Hales, TG; Hanna, MC; Kirkness, EF | 1 |
| Pomés, A; Rodríguez-Farré, E; Suñol, C; Vale, C | 1 |
| Cardinali, DP; Golombek, DA; Kanterewicz, BI; Rosenstein, RE; Yannielli, PC | 1 |
| Akaike, A; Sasa, M; Tsujiyama, S; Ujihara, H | 1 |
| Belachew, S; Coucke, P; Goffin, F; Lefebvre, PP; Malgrange, B; Moonen, G; Rigo, JM; Van de Water, TR; Xhauflaire, G | 1 |
| Berning, B; Gerner, FM; Hauser, CA; Rupprecht, R; Wetzel, CH | 1 |
| Bristow, DR; Brown, MJ; Coldwell, MC; Wood, MD | 2 |
| Chernet, E; Li, TK; Lumeng, L; McBride, WJ; Thielen, RJ | 1 |
| Andersson, G; Enerbäck, C; Engel, JA; Söderpalm, B | 1 |
| Mellor, JR; Randall, AD | 3 |
| Cook, CM; Cook, JM; Hu, RJ; Huang, Q; Hurt, SD; Liu, R; Skolnick, P; Trometer, JD | 1 |
| Buckingham, SD; Rauh, J; Sattelle, DB; Schnee, M | 1 |
| Barnes, EM; Baumgartner, BJ; Tehrani, MH | 1 |
| Granja, R; Gunnersen, D; Skolnick, P; Valeyev, A; Wong, G | 1 |
| Berger, T; Kraushaar, U; Monyer, H; Schwarz, C | 1 |
| Damgaard, I; Rodríguez-Farré, E; Schousboe, A; Suñol, C; Vale, C | 1 |
| Dunwiddie, TV; Proctor, WR; Soldo, BL | 1 |
| Deitrich, RA; Liu, Y | 1 |
| Bacigaluppo, JA; Colombo, MI; Marder, M; Medina, JH; Paladini, AC; Rúveda, EA; Viola, H; Wasowski, C; Wolfman, C | 1 |
| Hartmann, J; Kettenmann, H; Labrakakis, C; Patt, S | 1 |
| Chiu, TH; Li, M; Rosenberg, HC; Zhao, TJ | 1 |
| Atack, JR; McKernan, RM; Smith, AJ | 1 |
| Ayala-Grosso, CA; Urbina-Paez, R | 1 |
| Bailey, CD; Brien, JF; Reynolds, JN | 1 |
| Maitra, R; Reynolds, JN | 1 |
| Bateson, AN; Holt, RA; Martin, IL | 1 |
| Chiu, TH; Li, M; Rosenberg, HC; Walsh, LA; Zhao, TJ | 1 |
| Rodríguez-Farré, E; Suñol, C; Vale, C; Vilaró, MT | 1 |
| Higashi, H; Nagata, K; Park, JS; Yoshimura, M | 1 |
| Bédard, PJ; Blanchet, PJ; Calon, F; Di Paolo, T; Goulet, M; Grondin, R; Morissette, M | 1 |
| Bakonyi, A; Fekete, MI; Horváth, EJ; Palkovits, M; Salamon, C | 1 |
| Chéry, N; de Koninck, Y | 2 |
| Crites, GJ; Goldenberg, R; Malatynska, E; Schindler, NL; Tunnicliff, G; Yochum, A | 1 |
| Chavez, P; Nieves-Natal, J; Ortiz, JG | 1 |
| Crites, GJ; Goldenberg, R; Harrawood, D; Malatynska, E; Matheson, GK; Schindler, NL; Tunnicliff, G; Weinzapfel, D; Yochum, A | 1 |
| Ai, J; Kahnberg, P; Nielsen, M; Saederup, E; Squires, RF; Sterner, O; Witt, MR | 1 |
| Amico, C; Cupello, A; Robello, M | 1 |
| Bargas, J; Brailowsky, S; Calixto, E; Casasola, C; López-Colomé, AM; Montiel, T | 1 |
| Behrends, JC; Rumpel, E | 1 |
| Findlay, GS; Harris, RA; Harrison, NL; Ueno, S | 1 |
| Carroll, SS; Li, YH; McEwen, BS; Orchinik, M; Weiland, NG | 1 |
| Betti, L; Bistocchi, M; Giannaccini, G; Gori, M; Lucacchini, A | 1 |
| Mendonça-Silva, DL; Noël, F; Quintas, LE | 1 |
| Bennis, M; Chigr, F; Kopp, N; Miachon, S; Moyse, E; Najimi, M | 1 |
| Fiszer de Plazas, S; Pignataro, L | 1 |
| Farb, DH; Gibbs, TT; Land, MB; Lyons, HR | 1 |
| Davies, M; Dunn, SM; Newell, JG | 1 |
| Fonfría, E; Rodríguez-Farré, E; Suñol, C | 1 |
| Simmonds, MA; Sooksawate, T | 1 |
| Davies, PA; Hales, TG; Kirkness, EF | 1 |
| Kitazumi, K; Mori, M; Noguchi, H; Shiba, T | 1 |
| Cho, J; Choi, HC; Ha, JH; Kang, BS; Lee, DU; Lee, KY; Lim, JC | 1 |
| Battaglia, A; Calzà, L; Fernandez, M; Giardino, L; Pignataro, O; Zanni, M | 1 |
| Safo, P; Thompson, SA; Wafford, KA; Wheat, L; Whiting, PJ; Wingrove, PB | 1 |
| Berkovic, SF; Bowser, DN; Cromer, BA; Czajkowski, C; Harkin, LA; Jones, MV; Marini, C; Mulley, JC; Parker, MW; Petrou, S; Wagner, DA; Wallace, RH; Williams, DA | 1 |
| Andersen, DL; Burke, CJ; Dodd, PR; Eckert, AL; Tannenberg, AE; Tsai, VW | 1 |
| Cairns, D; Chazot, PL; Duggan, C; Lees, G; Rezai, N | 1 |
| Ambardekar, AV; Ilinsky, IA; Kultas-Ilinsky, K; Parts, K; Surin, A | 1 |
| Belcheva, I; Belcheva, S; Hadjiivanova, C | 1 |
| Akesson, P; Engel, JA; Söderpalm, B; Svensson, AI | 1 |
| Bäckström, T; Lundgren, P; Strömberg, J; Wang, M | 1 |
| Blednov, YA; Boehm, SL; Harris, RA; Peden, L | 1 |
| Caruso, RR; Castro, NG; Costa, PR; da Silva, AJ; Lopes, DV; Noël, F | 1 |
| Jembrek, MJ; Lazić, J; Pericić, D; Rajcan, I; Strac, DS | 1 |
| Bernöster, K; Dost, R; Egerland, U; Langen, B; Rundfeldt, C; Unverferth, K | 1 |
| Asproni, B; Biggio, G; Busonero, F; Cerri, R; Maciocco, E; Mascia, MP; Pau, A; Sanna, E; Talani, G | 1 |
| Chadda, R; Devaud, LL | 1 |
| Abuhamdah, S; Chazot, PL; Fürstner, A; Lees, G | 1 |
| Bujons, J; García, DA; Suñol, C; Vale, C | 1 |
| Bouairi, E; Gorini, C; Kamendi, H; Mendelowitz, D; Wang, X | 1 |
| Jembrek, MJ; Pericić, D; Strac, DS; Vlainić, J | 1 |
| Bavro, VN; Chan, SL; Chau, PL; Dunn, SM; Martin, IL; Mizuguchi, K; Mokrab, Y; Todorov, NP | 1 |
| Balon, N; Drolet, G; Genest, SE; Kinkead, R; Laforest, S | 1 |
| Collins, H; Cox, RF; Feldman, PL; Kilpatrick, GJ; Lovell, GG; McIntyre, MS; Pacofsky, GJ; Stafford, JA; Tilbrook, GS; Waszczak, BL; Wiard, RP | 1 |
| Bahr, BA; De Blas, AL; Li, X; Miralles, CP; Serwanski, DR | 1 |
| Brust, P; Deuther-Conrad, W; Ebert, B; Friemel, A; Hutson, PH; Nieber, K | 1 |
| Dzirkale, Z; Klusa, V; Krigere, L; Mezhapuke, R; Muceniece, R; Rumaks, J; Saleniece, K; Zharkova, O | 1 |
| Bostwick, R; Chen, T; Huston, J; Knappenberger, K; Liu, J; Norris, T; Wood, M | 1 |
| Dunn, SM; Kozuska, JL; Paulsen, IM; You, H | 1 |
| Alò, R; Avolio, E; Canonaco, M; Carelli, A | 1 |
| Cid, MP; Roth, GA; Rupil, LL; Salvatierra, NA; Vilcaes, AA | 1 |
| Ferreri, MC; Gravielle, MC; Gutiérrez, ML | 1 |
| Novozheeva, TP; Shushpanova, TV; Solonskii, AV; Udut, VV | 1 |
| Doyno, CR; White, CM | 1 |
| Hamilton, J; Neuman, J; Quattrin, T; Richardson, B; Roeder, N; Thanos, PK | 1 |
4 review(s) available for flunitrazepam and gamma-aminobutyric acid
| Article | Year |
|---|---|
Pharmacology of pyrazolopyridines.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Binding, Competitive; Drug Interactions; Ethanol; Flunitrazepam; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Male; Pyrazoles; Rats; Rats, Inbred Strains | 1985 |
Benzodiazepine receptors resolved.
Topics: Animals; Antibodies, Monoclonal; Autoradiography; Benzodiazepines; Benzodiazepinones; Bicuculline; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Chlorides; Clonazepam; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Histocytochemistry; Humans; Immunologic Techniques; Ionophores; Muscimol; Neurons; Radioisotopes; Radioligand Assay; Receptors, GABA-A; Spinal Cord; Synapses; Tissue Distribution | 1986 |
GABA and benzodiazepine receptors. Studies on their localization in the hippocampus and their interaction with central dopamine neurons in the rat brain.
Topics: Animals; Brain; Dopamine; Etazolate; Flunitrazepam; gamma-Aminobutyric Acid; Glutamates; Hippocampus; Muscimol; Neural Pathways; Neurons; Neurons, Afferent; Rats; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A | 1981 |
Benzodiazepine receptor multiplicity.
Topics: Animals; Brain; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Pyridazines; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
396 other study(ies) available for flunitrazepam and gamma-aminobutyric acid
| Article | Year |
|---|---|
Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits.
Topics: Adenosine Triphosphate; Allosteric Regulation; Animals; Benzodiazepines; Cells, Cultured; Enzyme Activation; Ethanol; Hippocampus; Humans; Mice; Mice, Knockout; Mutation; Phosphorylation; Protein Kinase C-epsilon; Protein Kinase Inhibitors; Protein Subunits; Pyridines; Receptors, GABA-A; Sensitivity and Specificity; Serine; Zolpidem | 2007 |
The effect of gamma-aminobutyric acid on 3H-flunitrazepam binding in rat brain.
Topics: Animals; Anti-Anxiety Agents; Binding Sites; Brain; Drug Interactions; Flunitrazepam; gamma-Aminobutyric Acid; Male; Rats | 1978 |
Modulation of benzodiazepine binding sites in calf cortex by an endogenous factor and GABAergic ligands.
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Cattle; Cerebral Cortex; Cycloleucine; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; Nerve Tissue Proteins; Receptors, Drug | 1979 |
Regional distribution of Na+-independent GABA and benzodiazepine binding sites in rat CNS.
Topics: Animals; Anti-Anxiety Agents; Brain; Brain Mapping; Flunitrazepam; gamma-Aminobutyric Acid; Rats; Sodium; Spinal Cord; Synaptic Membranes | 1979 |
Ontogeny of GABA and benzodiazepine receptors: effects of Triton X-100, bromide and muscimol.
Topics: Age Factors; Animals; Anti-Anxiety Agents; Bromides; Cerebellum; Female; Flunitrazepam; gamma-Aminobutyric Acid; Muscimol; Oxazoles; Polyethylene Glycols; Pregnancy; Rats; Receptors, Drug | 1979 |
GABA receptors in clonal cell lines: a model for study of benzodiazepine action at molecular level.
Topics: Animals; Benzodiazepines; Brain; Cell Line; Clonazepam; Clone Cells; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; Membrane Proteins; Mice; Nerve Tissue Proteins; Rats; Receptors, Drug | 1979 |
Solubilization of histamine H-1, GABA and benzodiazepine receptors.
Topics: Animals; Binding, Competitive; Brain; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Male; Muscimol; Pyrilamine; Rats; Receptors, Drug; Receptors, Histamine; Receptors, Histamine H1 | 1979 |
THIP and isoguvacine are partial agonists of GABA-stimulated benzodiazepine receptor binding.
Topics: Animals; Benzodiazepines; Cerebral Cortex; Drug Synergism; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Isonicotinic Acids; Isoxazoles; Muscimol; Oxazoles; Rats; Receptors, Drug | 1979 |
Resolution of two biochemically and pharmacologically distinct benzodiazepine receptors.
Topics: Animals; Benzodiazepines; Dose-Response Relationship, Drug; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Male; Membranes; Rats; Receptors, Drug; Synaptosomes; Triazoles | 1979 |
Heterogeneity in the allosteric interaction between the gamma-aminobutyric acid (GABA) binding site and three different benzodiazepine binding sites of the GABAA/benzodiazepine receptor complex in the rat nervous system.
Topics: Allosteric Site; Animals; Benzodiazepines; Binding Sites; Female; Flunitrazepam; gamma-Aminobutyric Acid; Male; Nervous System; Rats; Rats, Inbred Strains; Receptors, GABA-A; Tissue Distribution | 1992 |
5 beta-pregnan-3 beta-ol-20-one, a specific antagonist at the neurosteroid site of the GABAA receptor-complex.
Topics: Animals; Benzodiazepines; Binding, Competitive; Flunitrazepam; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Pentobarbital; Pregnanolone; Rats; Rats, Inbred Strains | 1992 |
Effect of diethyl pyrocarbonate modification of benzodiazepine receptors on [3H]Ro 15-4513 binding.
Topics: Animals; Appetite Depressants; Azides; Benzodiazepines; Carbolines; Cerebellum; Cerebral Cortex; Diazepam; Diethyl Pyrocarbonate; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Tritium | 1992 |
Chronic drug exposure downregulates GABAAergic transmission.
Topics: Animals; Down-Regulation; Flunitrazepam; gamma-Aminobutyric Acid; Rats; Receptors, GABA-A; Synaptic Transmission | 1992 |
Steroid modulation of amino acid neurotransmitter receptors.
Topics: Animals; Cells, Cultured; Chick Embryo; Electrophysiology; Flunitrazepam; gamma-Aminobutyric Acid; Glutamates; Pregnenolone; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Neurotransmitter; Steroids | 1992 |
Immortalized hypothalamic GT1-7 neurons express functional gamma-aminobutyric acid type A receptors.
Topics: Anesthetics; Animals; Barbiturates; Base Sequence; Bicuculline; Cell Line, Transformed; Cell Membrane; Chloride Channels; Diazepam; Electrophysiology; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression Regulation; Hypothalamus; Membrane Proteins; Mice; Molecular Sequence Data; Muscimol; Neurons; Peptides; Polymerase Chain Reaction; Receptors, GABA-A; RNA, Messenger; Sensitivity and Specificity; Steroids; Tritium; Tumor Cells, Cultured; Zinc | 1992 |
Adrenalectomy and stress modulate GABAA receptor function in LS and SS mice.
Topics: Adrenalectomy; Animals; Brain; Cerebellum; Cerebral Cortex; Chlorides; Corticosterone; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Learning; Male; Mice; Mice, Inbred Strains; Receptors, GABA-A; Reference Values; Sleep; Stress, Psychological | 1992 |
Amino acid neurotransmitter receptor changes in cerebral cortex in alcoholism: effect of cirrhosis of the liver.
Topics: Adult; Benzodiazepines; Binding Sites; Cerebral Cortex; Diazepam; Dizocilpine Maleate; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Liver Cirrhosis, Alcoholic; Male; Middle Aged; Receptors, Amino Acid; Receptors, Neurotransmitter | 1992 |
Functional alterations in cerebral GABAA receptor complex associated with formation of alcohol dependence: analysis using GABA-dependent 36Cl- influx into neuronal membrane vesicles.
Topics: Administration, Inhalation; Alcohol Withdrawal Delirium; Alcoholism; Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Flunitrazepam; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains; Muscimol; Neurons; Radioligand Assay; Receptors, GABA-A; Synaptic Membranes; Synaptic Vesicles | 1992 |
Benzodiazepine binding sites and their modulators in hippocampus of violent suicide victims.
Topics: Adolescent; Adult; Amino Acids; Asphyxia; Cause of Death; Child; Female; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Humans; Male; Middle Aged; Radioimmunoassay; Receptors, GABA-A; Suicide; Violence | 1992 |
Isolation and characterization of endogenous modulators for GABA system.
Topics: Animals; Brain Chemistry; Cations, Divalent; Cell Membrane; Drug Stability; Flunitrazepam; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamates; Glutamic Acid; Hot Temperature; Hydrogen-Ion Concentration; Molecular Weight; Muscimol; Pyrrolidonecarboxylic Acid; Swine | 1992 |
Functional expression of GABAA chloride channels and benzodiazepine binding sites in baculovirus infected insect cells.
Topics: Animals; Baculoviridae; Benzodiazepinones; Binding Sites; Cell Line; Cell Membrane; Chloride Channels; DNA; Electrophysiology; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Membrane Proteins; Moths; Rats; Receptors, GABA-A; Transfection | 1992 |
Taurine allosterically modulates flunitrazepam binding to synaptic membranes.
Topics: Animals; Bicuculline; Binding, Competitive; Cerebral Cortex; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Rats; Rats, Sprague-Dawley; Synaptic Membranes; Taurine; Temperature | 1992 |
Effect of chronic ethanol treatment on the gamma-aminobutyric acid-mediated enhancement of [3H]flunitrazepam binding in rat cortex and hippocampus.
Topics: Animals; Autoradiography; Benzodiazepines; Cerebral Cortex; Ethanol; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Male; Osmolar Concentration; Rats; Rats, Inbred Strains; Time Factors; Tissue Distribution; Tritium | 1992 |
Tricyclic heteroaromatic systems: [1]benzopyrano-pyrazol-4-ones as benzodiazepine receptor ligands.
Topics: Animals; Benzopyrans; Binding, Competitive; Cattle; Flunitrazepam; gamma-Aminobutyric Acid; Heterocyclic Compounds; In Vitro Techniques; Kinetics; Magnetic Resonance Spectroscopy; Pyrazoles; Receptors, GABA-A; Structure-Activity Relationship | 1991 |
gamma-Aminobutyric acid-activated chloride channels in rats selectively bred for differential acute sensitivity to alcohol.
Topics: Alcohol Drinking; Animals; Chloride Channels; Diazepam; Female; Flunitrazepam; gamma-Aminobutyric Acid; Membrane Proteins; Muscimol; Pentobarbital; Phenobarbital; Phenotype; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Selection, Genetic | 1991 |
Autoradiographic changes in central benzodiazepine binding sites and their coupling to gamma-aminobutyric acid receptors after seizures in the developing rat.
Topics: Age Factors; Animals; Animals, Newborn; Autoradiography; Brain; Female; Flunitrazepam; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Tissue Distribution | 1991 |
Agonist-dependent internalization of gamma-aminobutyric acidA/benzodiazepine receptors in chick cortical neurons.
Topics: Animals; Benzodiazepines; Cerebral Cortex; Chick Embryo; Clonazepam; Flunitrazepam; gamma-Aminobutyric Acid; Neurons; Osmolar Concentration; Receptors, GABA-A; Regression Analysis | 1991 |
Quantitative autoradiographic study of the postnatal development of benzodiazepine binding sites and their coupling to GABA receptors in the rat brain.
Topics: Aging; Animals; Autoradiography; Brain; Flunitrazepam; gamma-Aminobutyric Acid; Organ Specificity; Rats; Rats, Inbred Strains; Receptors, GABA-A; Tritium | 1991 |
The gamma 3-subunit of the GABAA-receptor confers sensitivity to benzodiazepine receptor ligands.
Topics: Amino Acid Sequence; Animals; Base Sequence; Benzodiazepines; Brain; Cloning, Molecular; Diazepam; Dose-Response Relationship, Drug; Flunitrazepam; gamma-Aminobutyric Acid; Molecular Sequence Data; Rats; Receptors, GABA-A | 1991 |
Biochemical and electrophysiologic evidence that propofol enhances GABAergic transmission in the rat brain.
Topics: Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chloride Channels; Dose-Response Relationship, Drug; Flunitrazepam; gamma-Aminobutyric Acid; Male; Membrane Proteins; Propofol; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptic Transmission | 1991 |
The interaction of tacrine with benzodiazepine and GABA binding sites of guinea pig brain.
Topics: Animals; Bicuculline; Binding, Competitive; Brain Chemistry; Cerebral Cortex; Flunitrazepam; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Kinetics; Radioligand Assay; Receptors, GABA-A; Tacrine | 1991 |
Modulation of benzodiazepine agonist and inverse-agonist receptor binding by GABA during ethanol withdrawal.
Topics: Animals; Azides; Benzodiazepines; Binding, Competitive; Brain; Cerebellum; Cerebral Cortex; Ethanol; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Male; Rats; Receptors, GABA-A; Substance Withdrawal Syndrome; Synaptic Transmission | 1991 |
Pharmacology of insect GABA receptors.
Topics: Acetylcholine; Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chloride Channels; Female; Flunitrazepam; gamma-Aminobutyric Acid; Houseflies; Insecticides; Male; Membrane Proteins; Nervous System; Neurons; Periplaneta; Pregnanes; Receptors, GABA-A; Synapses | 1991 |
Effects of methylazoxymethanol treatment on the GABAergic synaptosomes in the P2 fraction from developing mouse cerebellum.
Topics: Animals; Cerebellum; Flunitrazepam; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Methylazoxymethanol Acetate; Mice; Muscimol; Receptors, GABA-A; Synaptosomes | 1991 |
Inverse but not full benzodiazepine agonists modulate recombinant alpha 6 beta 2 gamma 2 GABAA receptors in transfected human embryonic kidney cells.
Topics: Action Potentials; Azides; Benzodiazepines; Carbolines; Cells, Cultured; Ethanol; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Kidney; Receptors, GABA-A; Recombinant Proteins; Transfection | 1991 |
Aging reduces the mRNA of alpha 1 GABAA receptor subunit in rat cerebral cortex.
Topics: Aging; Animals; Blotting, Northern; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Flunitrazepam; gamma-Aminobutyric Acid; Gene Expression Regulation; Macromolecular Substances; Male; Rats; Rats, Inbred F344; Receptors, GABA-A; RNA, Messenger; Transcription, Genetic; Tritium | 1991 |
Tricyclic heteroaromatic systems. Synthesis of 1,3 and 1,2 disubstituted [1]benzopyrano[4,3-b]pyrrol-4-ones and structure-activity relationships as benzodiazepine receptor ligands.
Topics: Animals; Benzopyrans; Binding, Competitive; Brain; Cattle; Cerebral Cortex; Chemical Phenomena; Chemistry, Physical; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Ligands; Pyrroles; Receptors, GABA-A; Structure-Activity Relationship | 1991 |
Characterization and differential regulation of GABAA and benzodiazepine receptors in rat neocortex.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Cerebral Cortex; Clonazepam; Down-Regulation; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Kinetics; Male; Muscimol; Pyridazines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Tritium; Veratridine | 1991 |
The effect of medetomidine on GABA and benzodiazepine receptors in vivo: lack of anxiolytic but some evidence of possible stress-protective activity.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Bicuculline; Brain; Cerebral Cortex; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Imidazoles; Kidney; Male; Medetomidine; Muscimol; Myocardium; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Stimulation, Chemical; Stress, Physiological; Tritium | 1991 |
Factors affecting actions of ethanol on GABA-activated chloride channels.
Topics: Animals; Chlorides; Cold Temperature; Ethanol; Female; Flunitrazepam; gamma-Aminobutyric Acid; Ion Channels; Mice; Pentobarbital; Time Factors | 1990 |
gamma-Aminobutyric acidA receptor regulation in culture: altered allosteric interactions following prolonged exposure to benzodiazepines, barbiturates, and methylxanthines.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Allosteric Regulation; Animals; Barbital; Barbiturates; Brain; Caffeine; Cells, Cultured; Chick Embryo; Flumazenil; Flunitrazepam; Flurazepam; gamma-Aminobutyric Acid; Kinetics; Neurons; Pentobarbital; Receptors, GABA-A; Tetrodotoxin; Theophylline; Veratridine | 1990 |
Experience influences environmental modulation of function at the benzodiazepine (BZD)/GABA receptor chloride channel complex.
Topics: Animals; Anxiety; Cell Membrane; Cerebral Cortex; Chloride Channels; Chlorides; Flunitrazepam; gamma-Aminobutyric Acid; Ion Channels; Male; Membrane Proteins; Rats; Rats, Inbred Strains; Receptors, GABA-A; Social Environment | 1991 |
Benzodiazepines do not potentiate GABA responses in neonatal hippocampal neurons.
Topics: Animals; Animals, Newborn; Drug Interactions; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Iontophoresis; Male; Midazolam; Neurons; Pentobarbital; Rats; Rats, Inbred Strains | 1991 |
Pharmacological and biochemical properties of the gamma-aminobutyric acid-benzodiazepine receptor protein from codfish brain.
Topics: Animals; Benzodiazepines; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Fishes; Flunitrazepam; gamma-Aminobutyric Acid; Ivermectin; Kinetics; Muscimol; Receptors, GABA-A; Tritium | 1991 |
Pharmacologic characterization of GABAA/benzodiazepine receptor in rat hippocampus during aging.
Topics: Aging; Animals; Binding Sites; Cerebellum; Cerebral Cortex; Culture Techniques; Drug Interactions; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Male; Muscimol; Pentobarbital; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1991 |
Characterization of recombinant GABAA receptors produced in transfected cells from murine alpha 1, beta 1, and gamma 2 subunit cDNAs.
Topics: Animals; Binding Sites; Cell Line; DNA; Electrophysiology; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Ligands; Mice; Muscimol; Receptors, GABA-A; Recombinant Proteins; Transfection | 1991 |
GABA, GABA receptors and benzodiazepine receptors in the human spinal cord: an autoradiographic and immunohistochemical study at the light and electron microscopic levels.
Topics: Autoradiography; Female; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Immunoenzyme Techniques; Male; Microscopy, Immunoelectron; Middle Aged; Receptors, GABA-A; Spinal Cord; Tritium | 1990 |
Tyr-MIF-1 binding in brain is not altered by ligands selective for the GABAA/benzodiazepine receptor.
Topics: Animals; Brain; Clonazepam; Flunitrazepam; gamma-Aminobutyric Acid; Male; MSH Release-Inhibiting Hormone; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Neurotransmitter | 1990 |
Effects of GABA and anxiolytics on the single unit discharge of suprachiasmatic neurons in rat hypothalamic slices.
Topics: Animals; Anti-Anxiety Agents; Azabicyclo Compounds; Baclofen; Bicuculline; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; Hypothalamus; In Vitro Techniques; Muscimol; Neurons; Piperazines; Rats; Receptors, GABA-A; Suprachiasmatic Nucleus | 1990 |
Determination of the membrane-buffer partition coefficient of flunitrazepam, a lipophilic drug.
Topics: Animals; Buffers; Cattle; Cerebral Cortex; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Ligands; Nerve Tissue Proteins; Neurons; Synaptic Membranes | 1991 |
Beta-alanine potentiation of [3H]flunitrazepam binding to rat spinal cord homogenates.
Topics: Alanine; Amino Acids; Animals; beta-Alanine; Drug Synergism; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Radioligand Assay; Rats; Rats, Inbred Strains; Spinal Cord; Strychnine; Tritium | 1990 |
Chronic agonist exposure induces down-regulation and allosteric uncoupling of the gamma-aminobutyric acid/benzodiazepine receptor complex.
Topics: Allosteric Regulation; Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Chick Embryo; Down-Regulation; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Muscimol; Pyridazines; Receptors, GABA-A | 1990 |
Stress-protection action of beta-phenyl(GABA): involvement of central and peripheral type benzodiazepine binding sites.
Topics: Animals; Behavior, Animal; Benzodiazepinones; Blood Proteins; Carbolines; Drug Combinations; Female; Flunitrazepam; gamma-Aminobutyric Acid; Male; Premedication; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stress, Physiological; Time Factors | 1990 |
Neurosteroids act on recombinant human GABAA receptors.
Topics: Benzodiazepines; Cell Line, Transformed; Cell Membrane Permeability; Chlorides; Desoxycorticosterone; Electric Conductivity; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Kidney; Membrane Potentials; Pentobarbital; Pregnanolone; Receptors, GABA-A; Recombinant Proteins; Transfection | 1990 |
Flunitrazepam photoaffinity labeling of the GABA(A) receptor reduces inhibition of [3H]Ro15-4513 binding by GABA.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Brain; Chick Embryo; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Membranes; Photochemistry; Receptors, GABA-A | 1990 |
Chronic benzodiazepine antagonist treatment and its withdrawal upregulates components of GABA-benzodiazepine receptor ionophore complex in cerebral cortex of rat.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Convulsants; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, GABA-A; Reference Values; Up-Regulation | 1990 |
The activity of zolpidem and other hypnotics within the gamma-aminobutyric acid (GABAA) receptor supramolecular complex, as determined by 35S-t-butylbicyclophosphorothionate (35S-TBPS) binding to rat cerebral cortex membranes.
Topics: Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Hypnotics and Sedatives; In Vitro Techniques; Male; Pyridines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Zolpidem | 1990 |
Binding of flunitrazepam to differentiating neurons cultured in a chemically defined, hormone-supplemented medium.
Topics: Animals; Cell Differentiation; Cells, Cultured; Culture Media; Flunitrazepam; gamma-Aminobutyric Acid; Hormones; Neurons | 1990 |
The role of striatopallidal neurones utilizing gamma-aminobutyric acid in the pathophysiology of MPTP-induced parkinsonism in the primate: evidence from [3H]flunitrazepam autoradiography.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Autoradiography; Brain; Carbidopa; Corpus Striatum; Deoxyglucose; Flunitrazepam; gamma-Aminobutyric Acid; Globus Pallidus; Levodopa; Macaca fascicularis; Neurons; Organ Specificity; Parkinson Disease; Parkinson Disease, Secondary; Tritium | 1990 |
Neurochemical effects of buspirone in rat hippocampus: evidence for selective activation of 5HT neurons.
Topics: Animals; Anti-Anxiety Agents; Brain Chemistry; Buspirone; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Hydroxyindoleacetic Acid; In Vitro Techniques; Neurons; Pyrimidines; Rats; Receptors, Serotonin; Serotonin | 1986 |
Flunitrazepam action on the GABA-Cl ionophore complex in rat cortical neurons in culture: a patch-clamp study.
Topics: Animals; Bicuculline; Cerebral Cortex; Chlorides; Flunitrazepam; gamma-Aminobutyric Acid; Ion Channels; Neurons; Osmolar Concentration; Rats | 1986 |
Stress-induced changes in t-[35S]butylbicyclophosphorothionate binding to gamma-aminobutyric acid-gated chloride channels are mimicked by in vitro occupation of benzodiazepine receptors.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cerebral Cortex; Chlorides; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Ion Channels; Kinetics; Male; Membranes; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stress, Physiological; Swimming | 1987 |
Functional expression in the Xenopus oocyte of messenger ribonucleic acids encoding brain neurotransmitter receptors: further characterisation of the implanted GABA receptor.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chick Embryo; Chlorides; Cloning, Molecular; DNA; Dose-Response Relationship, Drug; Flunitrazepam; gamma-Aminobutyric Acid; Gene Expression Regulation; Glycosylation; Ion Channels; Oocytes; Poly A; Receptors, GABA-A; RNA; RNA, Messenger; Xenopus | 1987 |
GABA receptors on the cell-body membrane of an identified insect motor neuron.
Topics: Androstanes; Animals; Azasteroids; Bicuculline; Chlorides; Cockroaches; Dibenzazepines; Dose-Response Relationship, Drug; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Ion Channels; Male; Membrane Potentials; Microelectrodes; Motor Neurons; Nipecotic Acids; Periplaneta; Picrotoxin; Receptors, GABA-A | 1988 |
Differences in the biophysical properties of the benzodiazepine/gamma-aminobutyric acid receptor chloride channel complex in the long-sleep and short-sleep mouse lines.
Topics: Animals; Azides; Benzodiazepines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chlorides; Flunitrazepam; gamma-Aminobutyric Acid; Heart; Ion Channels; Male; Mice; Mice, Mutant Strains; Receptors, GABA-A; Sleep | 1988 |
Developmental aspects of benzodiazepine receptors and GABA-gated chloride channels in primary cultures of spinal cord neurons.
Topics: Animals; Cells, Cultured; Chlorides; Flunitrazepam; gamma-Aminobutyric Acid; Ion Channels; Kinetics; Mice; Mice, Inbred C57BL; Receptors, GABA-A; Spinal Cord; Time Factors | 1988 |
Anion regulation of agonist and inverse agonist binding to benzodiazepine receptors.
Topics: Animals; Anions; Bromides; Carbolines; Cell Membrane; Cell Membrane Permeability; Cerebral Cortex; Chlorides; Flunitrazepam; Fluorides; gamma-Aminobutyric Acid; Iodides; Ion Channels; Male; Phospholipases A; Phospholipases A2; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stress, Physiological | 1988 |
Regional GABA/benzodiazepine receptor/chloride channel coupling after acute and chronic benzodiazepine treatment.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Bicuculline; Brain; Chlorides; Diazepam; Flunitrazepam; Flurazepam; gamma-Aminobutyric Acid; Ion Channels; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stimulation, Chemical | 1989 |
Chronic exposure to Ro 15-1788: differential effect on flunitrazepam binding to cortex and hippocampus.
Topics: Animals; Cerebral Cortex; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Kinetics; Male; Membranes; Rats; Rats, Inbred Strains; Synaptosomes | 1989 |
Postnatal evolution of the gamma-aminobutyric acid/benzodiazepine receptor complex in a model of inherited epilepsy: the quaking mouse.
Topics: Aging; Animals; Brain; Brain Stem; Cerebellum; Diazepam; Diencephalon; Epilepsy; Flunitrazepam; gamma-Aminobutyric Acid; Mice; Mice, Inbred C57BL; Mice, Quaking; Muscimol; Receptors, GABA-A; Telencephalon | 1989 |
n-[3H]butyl-beta-carboline-3-carboxylate, a putative endogenous ligand, binds preferentially to subtype 1 of central benzodiazepine receptors.
Topics: Animals; Brain; Carbolines; Cell Nucleus; Cerebral Cortex; Flunitrazepam; gamma-Aminobutyric Acid; Microsomes; Mitochondria; Pyridazines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptic Membranes | 1989 |
Distribution and pharmacological properties of the GABAA/benzodiazepine/chloride ionophore receptor complex in the brain of the fish Anguilla anguilla.
Topics: Anguilla; Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Convulsants; Flunitrazepam; gamma-Aminobutyric Acid; Ionophores; Male; Muscimol; Rats; Rats, Inbred Strains; Receptors, Drug; Receptors, GABA-A; Tissue Distribution | 1989 |
Ultraviolet irradiation selectively disrupts the gamma-aminobutyric acid/benzodiazepine receptor-linked chloride ionophore.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Chloride Channels; Chlorides; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Membrane Proteins; Rats; Rats, Inbred Strains; Receptors, GABA-A; Ultraviolet Rays | 1989 |
The pharmacological properties of GABA receptor-coupled chloride channels using 36Cl-influx in cultured spinal cord neurons.
Topics: Animals; Cells, Cultured; Chloride Channels; Chlorides; Flunitrazepam; gamma-Aminobutyric Acid; Membrane Proteins; Mice; Mice, Inbred C57BL; Receptors, GABA-A; Spinal Cord | 1989 |
Cerebral glutamine metabolism: study of modulatory effects of glutamine on gamma-aminobutyric acid-ergic neurotransmission.
Topics: Animals; Biological Transport; Brain; Chlorides; Flunitrazepam; gamma-Aminobutyric Acid; Glutamine; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptosomes | 1989 |
Immobilized GABAA receptors and their ligand binding characteristics.
Topics: Animals; Cerebral Cortex; Concanavalin A; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Ligands; Muscimol; Polylysine; Rats; Receptors, GABA-A; Solubility | 1989 |
Postmortem degradation alters fluorographic labeling patterns and affinities of benzodiazepine binding proteins.
Topics: Animals; Brain; Chickens; Flunitrazepam; Fluorometry; gamma-Aminobutyric Acid; Glycosylation; Peptide Hydrolases; Postmortem Changes; Rats; Receptors, GABA-A; Trout; Trypsin | 1989 |
Central- and peripheral-type benzodiazepine receptors: similar regulation by stress and GABA receptor agonists.
Topics: Animals; Anxiety; Baclofen; Behavior, Animal; Benzodiazepinones; Binding Sites; Brain; Flunitrazepam; gamma-Aminobutyric Acid; Kidney; Male; Mice; Muscimol; Myocardium; Rats; Receptors, GABA-A; Stress, Physiological | 1989 |
The modulation by chlormethiazole of the GABAA-receptor complex in rat brain.
Topics: Animals; Baclofen; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chlormethiazole; CLC-2 Chloride Channels; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Muscimol; Picrotoxin; Rats; Receptors, GABA-A | 1989 |
Chronic exposure of developing cortical neurons to GABA down-regulates GABA/benzodiazepine receptors and GABA-gated chloride currents.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Chick Embryo; Chlorides; Flunitrazepam; gamma-Aminobutyric Acid; Membrane Potentials; Neural Inhibition; Receptors, GABA-A | 1989 |
GABA preincubation of rat brain sections increases [3H]GABA binding to the GABAA receptor and compromises the modulatory interactions.
Topics: Animals; Autoradiography; Brain; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1989 |
Relative efficacies of 1,4-diazepines on GABA-stimulated chloride influx in rat brain vesicles.
Topics: Animals; Anti-Anxiety Agents; Azepines; Cell Membrane; Cerebral Cortex; Chlorides; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1989 |
Effect of ferric nitrilotriacetate on predominantly cortical neuronal cell cultures.
Topics: Acetates; Animals; Benzodiazepinones; Binding, Competitive; Cerebral Cortex; Choline O-Acetyltransferase; Clonazepam; Ferric Compounds; Flunitrazepam; gamma-Aminobutyric Acid; Mice; Neurons; Nitrilotriacetic Acid; Proteins | 1989 |
Solubilisation of the gamma-aminobutyric acid/benzodiazepine receptor from rat cerebellum: optimal preservation of the modulatory responses by natural brain lipids.
Topics: Animals; Cerebellum; Cholesterol Esters; Cholic Acids; Flunitrazepam; gamma-Aminobutyric Acid; Glycine max; Lipids; Male; Pentobarbital; Phospholipids; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Solubility; Solutions; Synaptic Membranes | 1987 |
Characteristics of flunitrazepam binding to intact primary cultured spinal cord neurons and its modulation by GABAergic drugs.
Topics: Animals; Benzodiazepines; Binding, Competitive; Carbolines; Cells, Cultured; Embryo, Mammalian; Etazolate; Etomidate; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Mice; Mice, Inbred C57BL; Muscimol; Neurons; Pentobarbital; Receptors, GABA-A; Spinal Cord | 1987 |
Further characterization of the avian benzodiazepine receptor subunits including phylo- and ontogenetic aspects.
Topics: Animals; Brain; Cerebellum; Chick Embryo; Chickens; Diencephalon; Flunitrazepam; gamma-Aminobutyric Acid; Mesencephalon; Phylogeny; Receptors, GABA-A; Reptiles; Spinal Cord; Telencephalon; Tissue Distribution | 1987 |
Benzodiazepine and GABAA receptors in rat brain following chronic antidepressant drug administration.
Topics: Animals; Antidepressive Agents; Brain; Desipramine; Flunitrazepam; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Tranylcypromine; Zimeldine | 1987 |
gamma-Aminobutyric acid and pentobarbital enhance 2-[3H]oxoquazepam binding to type I benzodiazepine recognition sites in rat and human brain.
Topics: Adult; Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Brain; Chlorides; Drug Synergism; Female; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Pentobarbital; Rats; Rats, Inbred Strains; Receptors, GABA-A; Tritium | 1988 |
GABA induces down-regulation of the benzodiazepine-GABA receptor complex in the rat cultured neurons.
Topics: Animals; Bicuculline; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Neurons; Radioligand Assay; Rats; Receptors, GABA-A | 1987 |
Heterogeneity of gamma-aminobutyric acid/benzodiazepine/beta-carboline receptor complex in rat spinal cord.
Topics: Animals; Bicuculline; Binding, Competitive; Carbolines; Cerebellum; Diazepam; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Male; Muscimol; Rats; Receptors, GABA-A; Spinal Cord; Synaptic Membranes | 1988 |
Osmotic shock: a method to eliminate endogenous gamma-aminobutyric acid and account for the influence on benzodiazepine binding affinity in autoradiographic studies.
Topics: Animals; Autoradiography; Benzodiazepines; Bicuculline; Binding Sites; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Male; Osmotic Pressure; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1988 |
Chronic caffeine or theophylline exposure reduces gamma-aminobutyric acid/benzodiazepine receptor site interactions.
Topics: Allosteric Regulation; Animals; Caffeine; Chick Embryo; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Receptors, GABA-A; Theophylline; Time Factors | 1988 |
Bicuculline up-regulation of GABAA receptors in rat brain.
Topics: Animals; Bicuculline; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Corpus Striatum; Flunitrazepam; Frontal Lobe; gamma-Aminobutyric Acid; Male; Muscimol; Octoxynol; Polyethylene Glycols; Rats; Rats, Inbred Strains; Receptors, GABA-A; Substantia Nigra; Synaptic Membranes | 1988 |
GABA down-regulates the GABA/benzodiazepine receptor complex in developing cerebral neurons.
Topics: Animals; Brain; Cells, Cultured; Chick Embryo; Chlorides; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Receptors, GABA-A | 1988 |
Evidence for modulation of GABAergic neurotransmission by nicotine.
Topics: Action Potentials; Allylglycine; Animals; Bicuculline; Brain Chemistry; Female; Flunitrazepam; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hippocampus; In Vitro Techniques; Mice; Mice, Inbred DBA; Nicotine; Receptors, GABA-A | 1988 |
Benzodiazepine receptor sites in the human brain: autoradiographic mapping.
Topics: Aged; Aged, 80 and over; Autoradiography; Brain; Brain Mapping; Female; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Postmortem Changes; Pyridazines; Receptors, GABA-A | 1988 |
Further characterization of benzodiazepine receptor differences in long-sleep and short-sleep mice.
Topics: Animals; Cerebellum; Cerebral Cortex; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Hot Temperature; In Vitro Techniques; Kinetics; Mice; Mice, Mutant Strains; Protein Conformation; Receptors, GABA-A; Sleep | 1988 |
Spinal cord cultured neurons: an in vitro model to study GABA synaptic pharmacology.
Topics: Animals; Cells, Cultured; Flunitrazepam; gamma-Aminobutyric Acid; Mice; Models, Neurological; Neurons; Receptors, GABA-A; Spinal Cord; Synapses | 1988 |
Rapid internalization of benzodiazepine receptors in the rat cortex induced by handling.
Topics: Animals; Bicuculline; Carbolines; Cerebral Cortex; Corticosterone; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Ligands; Male; Rats; Receptors, GABA-A; Stress, Physiological; Synaptic Membranes; Viscosity | 1988 |
The interaction of substituted benzamides with brain benzodiazepine binding sites in vitro.
Topics: Affinity Labels; Animals; Benzamides; Binding, Competitive; Brain Chemistry; Cattle; Cell Membrane; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Photochemistry; Receptors, GABA-A | 1988 |
The putative endogenous convulsant 3-hydroxykynurenine decreases benzodiazepine receptor binding affinity: implications to seizures associated with neonatal vitamin B-6 deficiency.
Topics: Animals; Brain; Convulsants; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Kynurenine; Male; Rats; Receptors, GABA-A; Seizures; Vitamin B 6 Deficiency | 1988 |
Pyritinol inhibition of the GABA and benzodiazepine receptor.
Topics: Animals; Central Nervous System; Cerebellum; Cerebral Cortex; Corpus Striatum; Diencephalon; Flunitrazepam; gamma-Aminobutyric Acid; Pyridines; Pyrithioxin; Rats; Receptors, GABA-A; Spinal Cord; Synaptic Membranes | 1988 |
Effect of benzodiazepines and pentobarbital on the GABA-induced depolarization in cultured astrocytes.
Topics: Animals; Astrocytes; Benzodiazepines; Benzodiazepinones; Brain; Cells, Cultured; Flunitrazepam; gamma-Aminobutyric Acid; Membrane Potentials; Pentobarbital; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1988 |
gamma-Aminobutyric acid modulation of benzodiazepine receptor binding in vitro does not predict the pharmacologic activity of all benzodiazepine receptor ligands.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Drug Evaluation, Preclinical; Drug Interactions; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Mice; Niacinamide; Receptors, GABA-A; Triazolam | 1985 |
gamma-Aminobutyric acid: temperature dependence in benzodiazepine receptor binding.
Topics: Animals; Anti-Anxiety Agents; Cell Membrane; Diencephalon; Flunitrazepam; gamma-Aminobutyric Acid; Mice; Muscimol; Receptors, GABA-A; Telencephalon; Temperature | 1985 |
Triazolam, an anomalous benzodiazepine receptor ligand: in vitro characterization of alprazolam and triazolam binding.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Carbolines; Clonazepam; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Triazolam | 1985 |
Neurotransmitter changes during development of cortical neuronal cultures.
Topics: Animals; Benzodiazepinones; Cells, Cultured; Cerebral Cortex; Choline O-Acetyltransferase; Clonazepam; Diazepam; Fetus; Flunitrazepam; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Mice; Neurotransmitter Agents | 1986 |
Development of gamma-aminobutyric acid (GABA)ergic neurons in cerebral cortical neurons in primary culture.
Topics: 4-Aminobutyrate Transaminase; Animals; Cell Differentiation; Cells, Cultured; Cerebral Cortex; Flunitrazepam; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamates; Glutamic Acid; Histocytochemistry; Immunoenzyme Techniques; Mice; Microscopy, Electron, Scanning; Muscimol; Receptors, GABA-A; Time Factors | 1987 |
[3H]Ro 15-1788 binding to benzodiazepine receptors in mouse brain in vivo: marked enhancement by GABA agonists and other CNS drugs.
Topics: Animals; Antipsychotic Agents; Barbiturates; Brain; Buspirone; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Injections, Intravenous; Male; Mice; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Vasodilator Agents | 1987 |
Modulation of GABA-stimulated chloride influx into membrane vesicles from rat cerebral cortex by benzodiazepines and nonbenzodiazepines.
Topics: Animals; Anti-Anxiety Agents; Cell Membrane; Cerebral Cortex; Chlorides; Clonazepam; Diazepam; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Rats; Rats, Inbred Strains | 1988 |
Chronic diazepam treatment produces regionally specific changes in GABA-stimulated chloride influx.
Topics: Animals; Cerebellum; Cerebral Cortex; Chlorides; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; Male; Membranes; Rats; Rats, Inbred Strains | 1989 |
Effects of guanyl nucleotides on [3H]flunitrazepam binding to rat hippocampal synaptic membranes: equilibrium binding and dissociation kinetics.
Topics: Adenosine Triphosphate; Animals; Benzodiazepinones; Diazepam; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Guanine Nucleotides; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Hippocampus; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptic Membranes | 1985 |
Allosteric modulation of flunitrazepam binding to rat brain benzodiazepine receptors by methyl beta-carboline-3-carboxylate.
Topics: Animals; Brain; Carbolines; Flunitrazepam; gamma-Aminobutyric Acid; Indoles; Kinetics; Rats; Receptors, GABA-A | 1985 |
Comparison of the effects of diphenylbarbituric acid, phenobarbital, pentobarbital and secobarbital on GABA-mediated inhibition and benzodiazepine binding.
Topics: Animals; Benzodiazepines; Electrophysiology; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Male; Pentobarbital; Phenobarbital; Rats; Rats, Inbred Strains; Receptors, GABA-A; Secobarbital; Time Factors | 1985 |
Effect of GABA agonists on the neurotoxicity and anticonvulsant activity of benzodiazepines.
Topics: Animals; Anticonvulsants; Benzodiazepines; Drug Synergism; Electroshock; Flunitrazepam; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Muscimol; Nervous System; Receptors, GABA-A | 1985 |
Identification of potential GABA-mimetics by their actions on brain GABA recognition sites.
Topics: 4-Aminobutyrate Transaminase; Animals; Binding, Competitive; Brain Chemistry; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Male; Mice; Receptors, GABA-A; Sodium | 1985 |
Benzodiazepine receptors and seizure susceptibility in epileptic fowl.
Topics: Animals; Animals, Newborn; Brain Chemistry; Chickens; Diazepam; Epilepsy; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Heterozygote; In Vitro Techniques; Kinetics; Membranes; Photic Stimulation; Receptors, GABA-A | 1985 |
Differential degradation of different benzodiazepine binding proteins by incubation of membranes from cerebellum or hippocampus with trypsin.
Topics: Affinity Labels; Androstanes; Animals; Azasteroids; Cell Membrane; Cerebellum; Electrophoresis, Polyacrylamide Gel; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Molecular Weight; Peptide Fragments; Photochemistry; Rats; Receptors, GABA-A; Trypsin | 1985 |
CM 40907: a structurally novel anticonvulsant in mice, rats and baboons.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain Chemistry; Electroshock; Epilepsy; Female; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Kindling, Neurologic; Male; Mice; Mice, Inbred Strains; Papio; Pyridazines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Tritium | 1985 |
Existence of sites for anions and divalent cations in the solubilized gamma-aminobutyric acid/benzodiazepine receptor complex.
Topics: Animals; Anions; Baclofen; Brain; Calcium Chloride; Cations, Divalent; Cattle; Cobalt; Flunitrazepam; gamma-Aminobutyric Acid; Hot Temperature; Magnesium; Magnesium Chloride; Receptors, GABA-A; Sodium Chloride; Zinc | 1985 |
Effect of picrotoxinin on benzodiazepine receptor binding.
Topics: Animals; Brain; Cerebellum; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Male; Membranes; Mice; Pentobarbital; Picrotoxin; Receptors, GABA-A; Sesterterpenes | 1985 |
Brain gamma-aminobutyric acid and benzodiazepine receptor binding in dialysis encephalopathy.
Topics: Benzodiazepinones; Brain Diseases; Flunitrazepam; Frontal Lobe; gamma-Aminobutyric Acid; Humans; Middle Aged; Receptors, GABA-A; Renal Dialysis | 1985 |
Aging: effect on the interaction of ethanol and pentobarbital with the benzodiazepine-GABA receptor-ionophore complex.
Topics: Aging; Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Ethanol; Flunitrazepam; gamma-Aminobutyric Acid; Ionophores; Kinetics; Male; Pentobarbital; Rats; Rats, Inbred F344; Receptors, GABA-A; Temperature | 1985 |
Benzodiazepine binding sites in mice forebrain and kidneys: evidence for similar regulation by GABA agonists.
Topics: Animals; Brain; Flunitrazepam; gamma-Aminobutyric Acid; Kidney; Male; Mice; Muscimol; Receptors, GABA-A | 1986 |
Ontogeny of the GABA receptor complex in chick brain: studies in vivo and in vitro.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Chick Embryo; Flunitrazepam; gamma-Aminobutyric Acid; Muscimol; Receptors, GABA-A | 1986 |
gamma-Aminobutyric acid, benzodiazepine binding sites and gamma-aminobutyric acid concentrations in epileptic E1 mouse brain.
Topics: Animals; Binding Sites; Brain; Epilepsy; Female; Flunitrazepam; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains; Muscimol; Receptors, GABA-A | 1985 |
Differential sensitivity of "central" and "peripheral" type benzodiazepine receptors to phospholipase A2.
Topics: Animals; Benzodiazepinones; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Cerebral Cortex; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Kidney; Male; Myocardium; Pentobarbital; Phospholipases; Phospholipases A; Phospholipases A2; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1986 |
Is GABA-stimulated [3H]flunitrazepam binding modulated by benzodiazepine receptor ligands?
Topics: Animals; Carbolines; Flunitrazepam; gamma-Aminobutyric Acid; Rats; Receptors, GABA-A | 1986 |
Regional difference in brain benzodiazepine receptor carbohydrates.
Topics: Acetylglucosaminidase; Animals; Asparagine; Benzodiazepinones; Brain Chemistry; Carbohydrates; Electrophoresis, Polyacrylamide Gel; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Male; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Molecular Weight; Muscimol; Neuraminidase; Pentobarbital; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sialic Acids; Tritium | 1986 |
Modulation of the GABA-benzodiazepine receptor complex by taurine in rat brain membranes.
Topics: Animals; Bicuculline; Brain; Flunitrazepam; gamma-Aminobutyric Acid; Male; Rats; Receptors, GABA-A; Taurine | 1986 |
Acute, stress-induced changes in the benzodiazepine/gamma-aminobutyric acid receptor complex are confined to the chloride ionophore.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bromides; Cerebral Cortex; Chlorides; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Iodides; Ionophores; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stress, Physiological; Sulfur Radioisotopes; Swimming; Tritium | 1986 |
Effects of pentylenetetrazol on GABA-A/benzodiazepine/picrotoxinin receptor complexes in rat brain regions.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebral Cortex; Corpus Striatum; Flunitrazepam; gamma-Aminobutyric Acid; Male; Muscimol; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Tissue Distribution | 1986 |
Effects of prenatal phenobarbital on benzodiazepine receptor development.
Topics: Animals; Brain; Cerebellum; Diencephalon; Female; Flunitrazepam; gamma-Aminobutyric Acid; Male; Mice; Phenobarbital; Pregnancy; Prenatal Exposure Delayed Effects; Pyridazines; Receptors, GABA-A; Telencephalon | 1986 |
Solubilization of the benzodiazepine/gamma-aminobutyric acid receptor complex: comparison of the detergents octylglucopyranoside and 3-[(3-cholamidopropyl)-dimethylammonio]1-propanesulfonate (CHAPS).
Topics: Animals; Carbolines; Cerebellum; Chlorides; Cholic Acids; Drug Stability; Flunitrazepam; gamma-Aminobutyric Acid; Glucosides; Glycosides; Male; Phospholipids; Pyrazoles; Rats; Receptors, GABA-A; Solubility; Synaptic Membranes | 1986 |
Heterogeneity of [3H]ethyl beta-carboline-3-carboxylate binding sites and [3H]gamma-aminobutyric acid binding sites.
Topics: Animals; Binding, Competitive; Carbolines; Cattle; Cerebral Cortex; Detergents; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Molecular Weight; Muscimol; Photolysis; Radioligand Assay; Receptors, GABA-A; Receptors, Neurotransmitter; Synaptosomes | 1986 |
Methodology for benzodiazepine receptor binding assays at physiological temperature. Rapid change in equilibrium with falling temperature.
Topics: Animals; Filtration; Flunitrazepam; gamma-Aminobutyric Acid; Radioligand Assay; Rats; Receptors, GABA-A; Temperature; Tritium | 1986 |
GABA enhancement of flunitrazepam binding in mice selectively bred for differential sensitivity to ethanol.
Topics: Animals; Brain; Ethanol; Female; Flunitrazepam; gamma-Aminobutyric Acid; Genetics, Behavioral; Mice; Molecular Conformation; Receptors, GABA-A; Sleep; Stimulation, Chemical; Time Factors | 1987 |
Coexistence of GABA receptors and GABA-modulin in primary cultures of rat cerebellar granule cells.
Topics: Animals; Carrier Proteins; Cells, Cultured; Cerebellum; Flunitrazepam; Fluorescent Antibody Technique; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Histocytochemistry; Membrane Proteins; Membrane Transport Proteins; Muscimol; Nerve Tissue Proteins; Organic Anion Transporters; Radioimmunoassay; Rats; Receptors, GABA-A; Synaptosomes | 1987 |
Responses to GABA by isolated insect neuronal somata: pharmacology and modulation by a benzodiazepine and a barbiturate.
Topics: Animals; Chemical Phenomena; Chemistry; Flunitrazepam; gamma-Aminobutyric Acid; Ganglia; Grasshoppers; In Vitro Techniques; Pentobarbital; Receptors, GABA-A; Species Specificity; Vertebrates | 1987 |
Phylogenetic comparison of the photoaffinity-labeled benzodiazepine receptor subunits.
Topics: Amphibians; Animals; Biological Evolution; Birds; Brain; Cell Membrane; Fishes; Flunitrazepam; gamma-Aminobutyric Acid; Genetic Variation; Mammals; Molecular Weight; Photochemistry; Phylogeny; Receptors, GABA-A; Reptiles | 1987 |
The benzodiazepine/GABA receptor complex in anxiety.
Topics: Animals; Anxiety; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Flunitrazepam; gamma-Aminobutyric Acid; Rats; Receptors, GABA-A; Stress, Physiological | 1986 |
Correlation between the enhancement of flunitrazepam binding by GABA and seizure susceptibility in mice.
Topics: 3-Mercaptopropionic Acid; Allosteric Regulation; Animals; Brain Chemistry; Dose-Response Relationship, Drug; Female; Flunitrazepam; gamma-Aminobutyric Acid; Mice; Mice, Inbred Strains; Phenotype; Receptors, GABA-A; Seizures; Species Specificity | 1987 |
Modulation of [3H]flunitrazepam binding to rat cerebellar benzodiazepine receptors by phosphatidylserine.
Topics: Animals; Cerebellum; Cholic Acids; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Phosphatidylserines; Pyrazoles; Rats; Receptors, GABA-A; Solubility; Synaptic Membranes; Tritium | 1987 |
Progress towards the understanding of the GABAA receptor structure.
Topics: Allosteric Site; Animals; Benzodiazepines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Cholic Acids; Deoxycholic Acid; Flunitrazepam; gamma-Aminobutyric Acid; Muscimol; Protein Binding; Receptors, GABA-A | 1987 |
Modulation of gamma-aminobutyric acid-mediated inhibitory synaptic currents in dissociated cortical cell cultures.
Topics: Animals; Bicuculline; Carbolines; Cells, Cultured; Cerebral Cortex; Electric Conductivity; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Membrane Potentials; Neural Inhibition; Rats; Synapses | 1986 |
Differences in GABA activity between ethanol withdrawal seizure prone and resistant mice.
Topics: Animals; Bicuculline; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Ethanol; Female; Flunitrazepam; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Picrotoxin; Seizures; Substance Withdrawal Syndrome | 1988 |
Regional mirex distribution and its effects on gamma-aminobutyric acid and flunitrazepam binding in mouse brains.
Topics: Animals; Brain; Carbon Radioisotopes; Drug Interactions; Flunitrazepam; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Insecticides; Kinetics; Male; Mice; Mirex; Synaptosomes; Tissue Distribution | 1987 |
Bicuculline-sensitive and insensitive effects of THIP on the binding of [3H]flunitrazepam.
Topics: Animals; Bicuculline; Brain; Dose-Response Relationship, Drug; Flunitrazepam; gamma-Aminobutyric Acid; Isoxazoles; Male; Osmolar Concentration; Oxazoles; Rats; Rats, Inbred Strains; Sodium Chloride; Tritium | 1987 |
Alterations in cerebral glutamic acid decarboxylase and 3H-flunitrazepam binding during continuous treatment of rats for up to 1 year with haloperidol, sulpiride or clozapine.
Topics: Animals; Body Weight; Brain; Clozapine; Flunitrazepam; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Haloperidol; Kinetics; Male; Psychotropic Drugs; Rats; Rats, Inbred Strains; Sulpiride; Time Factors | 1987 |
Comparative aspects of cerebellar [3H]flunitrazepam and [3H]GABA binding.
Topics: Animals; Binding Sites; Cerebellum; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Male; Mice; Mice, Inbred Strains; Nerve Tissue Proteins; Rabbits; Species Specificity; Synaptic Membranes; Synaptosomes | 1986 |
Characterization of Na+-independent GABA and flunitrazepam binding sites in preparations of synaptic membranes and postsynaptic densities isolated from canine cerebral cortex and cerebellum.
Topics: Animals; Cerebellum; Cerebral Cortex; Dogs; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Octoxynol; Organoids; Polyethylene Glycols; Receptors, Cell Surface; Receptors, GABA-A; Sodium; Synaptic Membranes | 1984 |
Differential localization of GABA-dependent and GABA-independent benzodiazepine binding sites within synapses of rat cerebral cortex.
Topics: Animals; Benzodiazepines; Cerebral Cortex; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Microscopy, Electron; Rats; Receptors, GABA-A; Synapses; Synaptosomes | 1984 |
Benzodiazepine receptor binding following amygdala-kindled convulsions: differing results in washed and unwashed brain membranes.
Topics: Amygdala; Animals; Benzodiazepinones; Brain; Buffers; Cell Membrane; Cerebral Cortex; Flunitrazepam; gamma-Aminobutyric Acid; Hypothalamus; Kindling, Neurologic; Male; Rats; Receptors, GABA-A; Seizures; Specimen Handling | 1984 |
Benzodiazepine receptor synthesis and degradation by neurons in culture.
Topics: Animals; Cells, Cultured; Chick Embryo; Flunitrazepam; gamma-Aminobutyric Acid; Half-Life; Kinetics; Neurons; Receptors, GABA-A; Spinal Cord | 1984 |
In vitro characterization of benzodiazepine receptor agonists, antagonists, inverse agonists and agonist/antagonists.
Topics: Animals; Brain; Chlorides; Etazolate; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Channels; Muscimol; Rats; Receptors, GABA-A | 1984 |
Biochemical evidence that 2-phenyl-4[(4-piperidinyl) ethyl]quinoline, a quinoline derivative with pure anticonflict properties, is a partial agonist of benzodiazepine receptors.
Topics: Animals; Brain; Conflict, Psychological; Cyclic GMP; Flunitrazepam; gamma-Aminobutyric Acid; Male; Quinolines; Rats; Receptors, GABA-A; Stimulation, Chemical | 1984 |
Analysis of benzodiazepine binding sites in rat pituitary gland.
Topics: Animals; Benzodiazepinones; Binding, Competitive; Clonazepam; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Pituitary Gland; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1984 |
Benzodiazepine binding sites in human pineal gland.
Topics: Adolescent; Adult; Aged; Animals; Benzodiazepinones; Binding, Competitive; Cerebral Cortex; Child; Child, Preschool; Clonazepam; Diazepam; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Humans; In Vitro Techniques; Infant; Kinetics; Male; Middle Aged; Pineal Gland; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1984 |
Modulation of neuronal function through benzodiazepine receptors: biochemical and electrophysiological studies of neurons in primary monolayer cell culture.
Topics: Animals; Benzodiazepines; Binding Sites; Cells, Cultured; Chick Embryo; Electrophysiology; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Membrane Potentials; Methionine; Neurons; Receptors, Neurotransmitter; Synaptic Membranes | 1984 |
Decreased convulsant potency of picrotoxin and pentetrazol and enhanced [3H]flunitrazepam cortical binding following stressful manipulations in rats.
Topics: Animals; Anti-Anxiety Agents; Cerebral Cortex; Diazepam; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Isoniazid; Male; Muscimol; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Stress, Physiological; Thiosemicarbazones | 1980 |
3H-Flunitrazepam binding to bovine retina and the effect of GABA thereon.
Topics: Animals; Anti-Anxiety Agents; Cattle; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Retina | 1980 |
Solubilization and properties of a benzodiazepine receptor from calf cortex.
Topics: Animals; Anti-Anxiety Agents; Cattle; Cerebral Cortex; Flunitrazepam; gamma-Aminobutyric Acid; Molecular Weight; Receptors, Drug; Solubility | 1980 |
Benzodiazepine receptors: the effect of GABA on their characteristics in human brain and their alteration in Huntington's disease.
Topics: Aged; Anti-Anxiety Agents; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Huntington Disease; Putamen; Receptors, Drug; Substantia Nigra | 1980 |
Autoradiographic localization of binding sites for [3H]gamma-aminobutyrate, [3H]muscimol,(+)[3H]bicuculline methiodide and [3H] flunitrazepam in cultures of rat cerebellum and spinal cord.
Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Autoradiography; Bicuculline; Binding Sites; Cells, Cultured; Cerebellum; Female; Fetus; Flunitrazepam; gamma-Aminobutyric Acid; Muscimol; Oxazoles; Pregnancy; Rats; Receptors, Drug; Spinal Cord; Tritium | 1980 |
Audiogenic seizures: increased benzodiazepin receptor binding in a susceptible strain of mice.
Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Binding Sites; Brain; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Mice; Receptors, Drug; Seizures; Species Specificity | 1980 |
Studies on the properties of benzodiazepine-binding sites from calf cortex.
Topics: Animals; Anti-Anxiety Agents; Cattle; Cerebral Cortex; Flunitrazepam; gamma-Aminobutyric Acid; Membranes; Receptors, Drug; Subcellular Fractions | 1980 |
Modulation by picrotoxin and IPTBO of 3H-flunitrazepam binding to the GABA/benzodiazepine receptor complex of rat cerebellum.
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Binding Sites; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Cerebellum; Etazolate; Flunitrazepam; gamma-Aminobutyric Acid; Male; Membranes; Organophosphorus Compounds; Picrotoxin; Rats; Receptors, Drug; Receptors, GABA-A; Temperature | 1981 |
Autoradiographic localization of benzodiazepine receptors in immunocytochemically identified gamma-aminobutyrergic synapses.
Topics: Affinity Labels; Animals; Anti-Anxiety Agents; Autoradiography; Cerebellar Cortex; Flunitrazepam; gamma-Aminobutyric Acid; Receptors, Drug; Receptors, GABA-A; Synapses; Tritium | 1981 |
gamma-Aminobutyric acid and benzodiazepine receptors: copurification and characterization.
Topics: Animals; Anti-Anxiety Agents; Binding, Competitive; Brain; Cattle; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A | 1981 |
gamma-Aminobutyric acid regulation of the benzodiazepine receptor: biochemical evidence for pharmacologically different effects of benzodiazepines and propyl beta-carboline-3-carboxylate.
Topics: Anti-Anxiety Agents; Binding, Competitive; Carbolines; Flunitrazepam; gamma-Aminobutyric Acid; Indoles; Receptors, Drug; Receptors, GABA-A; Receptors, Neurotransmitter | 1981 |
Benzodiazepine binding and interactions with the GABA receptor complex in living cultures of rat cerebral cortex.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Binding, Competitive; Cells, Cultured; Cerebral Cortex; Chlorides; Diazepam; Fetus; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Membrane Potentials; Neurons; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1981 |
Stimulation of benzodiazepine binding to rat brain membranes and solubilized receptor complex by avermectin B1a and gamma-aminobutyric acid.
Topics: Animals; Anthelmintics; Anti-Anxiety Agents; Bicuculline; Brain; Chlorides; Flunitrazepam; gamma-Aminobutyric Acid; Ion Channels; Ivermectin; Lactones; Male; Rats; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Synaptic Membranes | 1981 |
6 -Hydroxydopamine decreases benzodiazepine but not GABA receptor binding in rat cerebellum.
Topics: Animals; Cerebellum; Flunitrazepam; gamma-Aminobutyric Acid; Hydroxydopamines; Male; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Receptors, Neurotransmitter; Tyrosine 3-Monooxygenase | 1981 |
gamma-Aminobutyric acid (GABA) receptor stimulation. II. Specificity of progabide (SL 76002) and SL 75102 for the GABA receptor.
Topics: Animals; Brain; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Ligands; Muscimol; Neurotransmitter Agents; Rabbits; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1982 |
Enhancement of benzodiazepine and GABA binding by the novel anxiolytic, tracazolate.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Brain; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Ligands; Male; Pyrazoles; Rats; Rats, Inbred Strains; Stimulation, Chemical; Synaptic Membranes | 1982 |
Properties of benzodiazepine receptors in rat retina.
Topics: Animals; Anthelmintics; Anti-Anxiety Agents; Cerebellum; Etazolate; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Ivermectin; Lactones; Molecular Weight; Pyridazines; Rats; Receptors, Drug; Receptors, GABA-A; Receptors, Neurotransmitter; Retina | 1982 |
Benzodiazepines and gamma-aminobutyric acid.
Topics: Animals; Anti-Anxiety Agents; Binding, Competitive; Diazepam; Evoked Potentials; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Neural Inhibition; Raphe Nuclei; Receptors, Drug; Receptors, GABA-A; Synaptic Transmission | 1982 |
Anion-dependent modulation of [3H]muscimol binding and of GABA-stimulated [3H]flunitrazepam binding by picrotoxin and related CNS convulsants.
Topics: Animals; Anions; Anti-Anxiety Agents; Cerebral Cortex; Convulsants; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Muscimol; Oxazoles; Picrotoxin; Rats; Receptors, Drug; Receptors, GABA-A; Strychnine; Tubocurarine | 1982 |
Kinetics of [3H]flunitrazepam binding to membrane-bound benzodiazepine receptors.
Topics: Animals; Anti-Anxiety Agents; Cerebral Cortex; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Male; Membranes; Protein Conformation; Rats; Rats, Inbred Strains; Receptors, Drug; Receptors, GABA-A; Synaptosomes; Time Factors | 1982 |
Interaction of [3H]flunitrazepam with the benzodiazepine receptor: evidence for a ligand-induced conformation change.
Topics: Animals; Anti-Anxiety Agents; Brain; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Ligands; Membranes; Protein Conformation; Rats; Receptors, Drug; Receptors, GABA-A | 1982 |
Comparison of the kinetics of [3H]diazepam and [3H]flunitrazepam binding to cortical synaptosomal membranes.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Cerebral Cortex; Diazepam; Filtration; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Male; Pentobarbital; Rats; Rats, Inbred Strains; Sodium Chloride; Synaptic Membranes | 1982 |
GABA and flunitrazepam binding to neuroblastoma cell membranes--effects of growth conditions, ethanol and pentobarbital.
Topics: Anti-Anxiety Agents; Binding, Competitive; Cell Line; Culture Media; Culture Techniques; Ethanol; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Kinetics; Neuroblastoma; Pentobarbital; Receptors, Cell Surface; Receptors, GABA-A | 1982 |
Biochemical development of the human brain. III. Benzodiazepine receptors, free gamma-aminobutyrate (GABA) and other amino acids.
Topics: Adult; Aged; Aging; Amino Acids; Aspartic Acid; Brain; Cerebellum; Female; Flunitrazepam; Frontal Lobe; gamma-Aminobutyric Acid; Gestational Age; Glutamate Decarboxylase; Glutamates; Glutamic Acid; Glutamine; Humans; Infant; Infant, Newborn; Kinetics; Middle Aged; Pregnancy; Receptors, Cell Surface; Receptors, GABA-A | 1982 |
Etazolate (SQ20009): electrophysiology and effects on [3H]flunitrazepam binding in cultured cortical neurons.
Topics: Animals; Anti-Anxiety Agents; Binding Sites; Cells, Cultured; Cerebral Cortex; Electric Conductivity; Electrophysiology; Etazolate; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Neurons; Nicotinic Acids; Rats; Synapses | 1983 |
The effect of temperature and chloride ions on the stimulation of [3H]flunitrazepam binding by the muscimol analogues THIP and piperidine-4-sulfonic acid.
Topics: Animals; Anti-Anxiety Agents; Chlorides; Flunitrazepam; gamma-Aminobutyric Acid; Isonicotinic Acids; Isoxazoles; Oxazoles; Piperidines; Rats; Stimulation, Chemical; Temperature; Tritium | 1980 |
Effect of GABA and benzodiazepine antagonists on [3H]flunitrazepam binding to cerebral cortical membrane.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Binding, Competitive; Cattle; Cerebral Cortex; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Benzodiazepine receptors in fish brain: [3H]-flunitrazepam binding and modulatory effects of GABA in rainbow trout.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Binding, Competitive; Brain; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Male; Receptors, Cell Surface; Receptors, GABA-A; Trout | 1983 |
Studies on the neurotransmitter binding to pig brain microvessels.
Topics: Animals; Brain; Capillaries; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Microcirculation; Neurotransmitter Agents; Swine; Synaptic Membranes; Ultracentrifugation | 1983 |
Characterization of flunitrazepam and beta-carboline high affinity binding in bovine pineal gland.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Binding Sites; Carbolines; Cattle; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Indoles; Kinetics; Pentobarbital; Pineal Gland; Rats; Species Specificity | 1983 |
Neuronal [3H]benzodiazepine binding and levels of GABA, glutamate, and taurine are normal in Huntington's disease cerebellum.
Topics: Amino Acids; Cerebellum; Flunitrazepam; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Haloperidol; Humans; Huntington Disease; Middle Aged; Neurons; Receptors, Cell Surface; Receptors, GABA-A; Taurine | 1983 |
The quinolines PK 8165 and PK 9084 possess benzodiazepine-like activity in vitro but not in vivo.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Brain; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Mice; Quinolines; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1984 |
Increased number of brain benzodiazepine receptors after in-vivo administration of estazolam to rats.
Topics: Animals; Anti-Anxiety Agents; Binding Sites; Brain; Cerebellum; Diazepam; Estazolam; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Kinetics; Male; Rats; Receptors, GABA-A | 1984 |
The GABA/benzodiazepine receptor complex in the nervous system of a hypertensive strain of rat.
Topics: Aging; Animals; Brain; Cerebellum; Cerebral Cortex; Flunitrazepam; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hypertension; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, GABA-A; Synaptic Membranes | 1984 |
Central benzodiazepine receptors in the spinal cord and other regions of the CNS of the cat.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Binding, Competitive; Cats; Central Nervous System; Cerebellum; Cerebral Cortex; Female; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Male; Receptors, GABA-A; Spinal Cord | 1984 |
Convulsions induced by lindane and the involvement of the GABAergic system.
Topics: Animals; Flunitrazepam; gamma-Aminobutyric Acid; Hexachlorocyclohexane; Male; Rats; Rats, Inbred Strains; Seizures; Time Factors | 1983 |
Multiple benzodiazepine receptor complexes: some benzodiazepine recognition sites are coupled to GABA receptors and ionophores.
Topics: Animals; Anions; Benzodiazepines; Bicuculline; Brain; Buffers; Flunitrazepam; gamma-Aminobutyric Acid; Haplorhini; Hot Temperature; Ionophores; Isonicotinic Acids; Isoxazoles; Macromolecular Substances; Papio; Rats; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Receptors, Neurotransmitter | 1980 |
Molecular heterogeneity of benzodiazepine receptors.
Topics: Animals; Benzodiazepines; Brain; Cerebellum; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Membrane Proteins; Molecular Weight; Nerve Tissue Proteins; Rats; Receptors, Drug; Receptors, GABA-A; Receptors, Neurotransmitter | 1980 |
In vitro modulation by avermectin B1a of the GABA/benzodiazepine receptor complex of rat cerebellum.
Topics: Animals; Cerebellum; Etazolate; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Ivermectin; Lactones; Octoxynol; Polyethylene Glycols; Pyrazoles; Rats; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A | 1981 |
Differential ontogeny of type 1 and type 2 benzodiazepine receptors.
Topics: Animals; Brain; Female; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Pregnancy; Protein Binding; Pyridazines; Rats; Receptors, Drug; Receptors, GABA-A | 1981 |
Reductions in retinal gamma-aminobutyric acid (GABA) content and in [3H]flunitrazepam binding after postnatal monosodium glutamate injections in rats.
Topics: Animals; Animals, Newborn; Brain; Flunitrazepam; gamma-Aminobutyric Acid; Glutamates; Male; Rats; Receptors, Drug; Receptors, GABA-A; Retina; Sodium Glutamate | 1981 |
Benzodiazepine receptors are coupled to a subpopulation of gamma-aminobutyric acid (GABA) receptors: evidence from a quantitative autoradiographic study.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Flunitrazepam; gamma-Aminobutyric Acid; Male; Photomicrography; Rats; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A | 1981 |
Soluble gamma-aminobutyric acid and benzodiazepine receptors from rat cerebral cortex.
Topics: Animals; Benzodiazepines; Binding, Competitive; Cell Fractionation; Cerebral Cortex; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Mitochondria; Muscimol; Rats; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Solubility; Synaptosomes | 1981 |
Multiple benzodiazepine receptors and their regulation by gamma-aminobutyric acid.
Topics: Animals; Benzodiazepines; Binding, Competitive; Brain; Carbolines; Flunitrazepam; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred Strains; Receptors, Drug; Receptors, GABA-A | 1981 |
Chloride-dependent stimulation of GABA and benzodiazepine receptor binding by pentobarbital.
Topics: Animals; Brain; Cattle; Chlorides; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Pentobarbital; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A | 1981 |
Involvement of tyrosyl residues in the binding of benzodiazepines to their brain receptors.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Brain; Cattle; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; Imidazoles; Nitrazepam; Receptors, Drug; Receptors, GABA-A; Receptors, Neurotransmitter; Tetranitromethane; Tyrosine | 1981 |
Ontogeny of high-affinity GABA and benzodiazepine receptors in the rat cerebellum: an autoradiographic study.
Topics: Aging; Animals; Autoradiography; Cerebellum; Clonazepam; Female; Flunitrazepam; gamma-Aminobutyric Acid; Muscimol; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A | 1981 |
Barbiturate and GABA receptors coupled to benzodiazepine receptors in rat hippocampal formation: a radiohistochemical study.
Topics: Animals; Autoradiography; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Histocytochemistry; Male; Pentobarbital; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Receptors, Neurotransmitter | 1981 |
gamma-Aminobutyric acid enhancement of CL 218,872 affinity and evidence of benzodiazepine receptor heterogeneity.
Topics: Animals; Bicuculline; Binding, Competitive; Brain; Cattle; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Kidney; Kinetics; Pyridazines; Receptors, Drug; Receptors, GABA-A; Retina | 1981 |
CGS 8216: receptor binding characteristics of a potent benzodiazepine antagonist.
Topics: Animals; Benzodiazepines; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, Drug; Receptors, GABA-A; Temperature; Tritium | 1982 |
Effect of ethanol administration and withdrawal on benzodiazepine receptor binding in the rat brain.
Topics: Animals; Brain; Ethanol; Flunitrazepam; gamma-Aminobutyric Acid; Humans; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Drug; Receptors, GABA-A; Substance Withdrawal Syndrome | 1982 |
Physicochemical characterization of detergent-solubilized gamma-aminobutyric acid and benzodiazepine receptor proteins from bovine brain.
Topics: Animals; Cattle; Centrifugation, Density Gradient; Cerebral Cortex; Chemical Phenomena; Chemistry, Physical; Chromatography, Gel; Deoxycholic Acid; Flunitrazepam; gamma-Aminobutyric Acid; Molecular Weight; Muscimol; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Solubility | 1982 |
Binding of a radiolabeled triazolopyridazine to a subtype of benzodiazepine receptor in the rat cerebellum.
Topics: Animals; Anions; Cerebellum; Flunitrazepam; gamma-Aminobutyric Acid; Male; Pentobarbital; Pyrazoles; Pyridazines; Rats; Rats, Inbred Strains; Receptors, Drug; Receptors, GABA-A | 1982 |
Influence of morphine dependence on GABA-stimulated benzodiazepine binding to mouse brain synaptic membranes.
Topics: Animals; Brain; Flunitrazepam; gamma-Aminobutyric Acid; Humans; In Vitro Techniques; Kinetics; Male; Mice; Mice, Inbred ICR; Morphine Dependence; Receptors, Drug; Receptors, GABA-A; Synaptic Membranes | 1982 |
gamma-Aminobutyric acid and benzodiazepine binding sites in audiogenic seizure-susceptible mice.
Topics: Acoustic Stimulation; Aging; Animals; Benzodiazepines; Brain; Cell Membrane; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Mice; Mice, Inbred DBA; Mice, Inbred Strains; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Seizures | 1982 |
A novel pyrazoloquinoline that interacts with brain benzodiazepine receptors: characterization of some in vitro and in vivo properties of CGS 9896.
Topics: Animals; Anticonvulsants; Brain; Chlorides; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, Drug; Receptors, GABA-A | 1982 |
The influence of temperature and gamma-aminobutyric acid on benzodiazepine receptor subtypes in the hippocampus of the rat.
Topics: Animals; Benzodiazepines; Binding, Competitive; Carbolines; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Drug; Receptors, GABA-A | 1982 |
Effects of agents which enhance GABA-mediated neurotransmission on licking conflict in rats and exploration in mice.
Topics: Animals; Conflict, Psychological; Diazepam; Exploratory Behavior; Flunitrazepam; gamma-Aminobutyric Acid; Male; Mice; Muscimol; Nitrazepam; Rats; Rats, Inbred Strains; Synaptic Transmission; Urethane; Valproic Acid | 1982 |
Isolation of a GABA receptor from bovine brain using a benzodiazepine affinity column.
Topics: Animals; Cattle; Cell Membrane; Cerebral Cortex; Chromatography, Affinity; Clorazepate Dipotassium; Flunitrazepam; gamma-Aminobutyric Acid; Muscimol; Receptors, Cell Surface; Receptors, GABA-A | 1982 |
Quantitative autoradiography of neurotransmitter receptors in Huntington disease.
Topics: Adult; Autoradiography; Brain; Female; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Huntington Disease; Muscimol; Receptors, Amino Acid; Receptors, Drug; Receptors, GABA-A; Receptors, Muscarinic; Receptors, Neurotransmitter | 1982 |
GABA abolishes cooperativity between benzodiazepine receptors.
Topics: Animals; Brain; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1982 |
Regional heterogeneity of benzodiazepine binding sites in rat brain.
Topics: Animals; Binding, Competitive; Brain; Carbolines; Cerebellum; Chlorides; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Kinetics; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1982 |
Characterization of the solubilized GABA and benzodiazepine receptors from various regions of bovine brain.
Topics: Animals; Benzodiazepines; Brain; Brain Chemistry; Cattle; Cerebellum; Cerebral Cortex; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Molecular Weight; Muscimol; Organ Specificity; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Characterization of solubilized benzodiazepine and muscimol binding sites from rat brain.
Topics: Animals; Brain; Chromatography, Ion Exchange; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Isoelectric Focusing; Rats; Receptors, Cell Surface; Receptors, GABA-A; Ultrafiltration | 1982 |
Benzodiazepine receptor sites in bovine pineal.
Topics: Animals; Cattle; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Membranes; Pineal Gland; Receptors, Cell Surface; Receptors, GABA-A | 1982 |
Suriclone: a new cyclopyrrolone derivative recognizing receptors labeled by benzodiazepines in rat hippocampus and cerebellum.
Topics: Animals; Binding, Competitive; Cerebellum; Cerebral Cortex; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Hot Temperature; Kinetics; Male; Naphthyridines; Piperazines; Rats; Receptors, Cell Surface; Receptors, GABA-A; Sulfur Compounds; Time Factors | 1983 |
Molecular sizes of photolabeled GABA and benzodiazepine receptor proteins are identical.
Topics: Animals; Benzodiazepines; Cerebellum; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Muscimol; Rats; Receptors, Cell Surface; Receptors, GABA-A; Synaptosomes | 1983 |
Differential effect of gamma-aminobutyric acid on benzodiazepine receptor subtypes labeled by [3H]propyl beta-carboline-3-carboxylate in rat brain.
Topics: Animals; Binding, Competitive; Brain; Carbolines; Cerebellum; Cerebral Cortex; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Indoles; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Inhibition of GABA and benzodiazepine receptor binding by penicillins.
Topics: Animals; Benzodiazepines; Brain; Flunitrazepam; gamma-Aminobutyric Acid; Penicillins; Rats; Receptors, Cell Surface; Receptors, GABA-A; Structure-Activity Relationship | 1980 |
PK 8165 and PK 9084, two quinoline derivatives with anxiolytic properties, antagonize the anticonvulsant effects of diazepam.
Topics: Animals; Anticonvulsants; Benzodiazepines; Bicuculline; Brain; Diazepam; Drug Antagonism; Flunitrazepam; gamma-Aminobutyric Acid; Male; Mice; Quinolines; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1983 |
A gamma-aminobutyric acid/benzodiazepine receptor complex of bovine cerebral cortex.
Topics: Animals; Benzodiazepines; Cattle; Cerebral Cortex; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Macromolecular Substances; Molecular Weight; Muscimol; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Kindled seizures result in decreased responsiveness of benzodiazepine receptors to gamma-aminobutyric acid (GABA).
Topics: Animals; Flunitrazepam; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Pentobarbital; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures; Sodium Chloride | 1983 |
Solubilization of brain benzodiazepine receptors with a zwitterionic detergent: optimal preservation of their functional interaction with the GABA receptors.
Topics: Animals; Brain Chemistry; Cholic Acids; Flunitrazepam; gamma-Aminobutyric Acid; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Solubility | 1983 |
Enhanced binding of radioligands to receptors of gamma-aminobutyric acid and benzodiazepine by a new anticonvulsive agent, LY81067.
Topics: Animals; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Flunitrazepam; gamma-Aminobutyric Acid; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures; Triazines | 1983 |
An allosteric model for benzodiazepine receptor function.
Topics: Animals; Carbolines; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Models, Biological; Radioligand Assay; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
[3H]muscimol binding site on purified benzodiazepine receptor.
Topics: Animals; Binding Sites; Brain; Flunitrazepam; gamma-Aminobutyric Acid; Molecular Weight; Muscimol; Oxazoles; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Protection of soluble benzodiazepine receptors from heat inactivation by GABAergic ligands.
Topics: Animals; Cattle; Deoxycholic Acid; Drug Stability; Flunitrazepam; gamma-Aminobutyric Acid; Hot Temperature; Imidazoles; Octoxynol; Polyethylene Glycols; Receptors, Cell Surface; Receptors, GABA-A; Solubility | 1983 |
Effects of GABA receptor agonists on [3H] flunitrazepam binding to rat cerebellar and hippocampal membranes.
Topics: Animals; Cerebellum; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Imidazoles; Male; Membranes; Muscimol; Piperidines; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Two distinct solubilized benzodiazepine receptors: differential modulation by ions.
Topics: Animals; Anions; Brain; Cations, Divalent; Cattle; Chlorides; Female; Flunitrazepam; gamma-Aminobutyric Acid; Hot Temperature; Oxidation-Reduction; Receptors, Cell Surface; Receptors, GABA-A; Solubility | 1983 |
Autoradiographic localization of binding sites for inhibitory amino acids and their antagonists in cultured rat CNS.
Topics: Amino Acids; Animals; Animals, Newborn; Autoradiography; Bicuculline; Brain Stem; Cells, Cultured; Cerebellum; Female; Fetus; Flunitrazepam; gamma-Aminobutyric Acid; Muscimol; Neuroglia; Neurons; Pregnancy; Rats; Receptors, Cell Surface; Spinal Cord; Tritium | 1983 |
The effects of kindling on GABA-mediated inhibition in the dentate gyrus of the rat. II. Receptor binding.
Topics: Amygdala; Animals; Brain; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Kindling, Neurologic; Male; Muscimol; Neural Inhibition; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Decreased high-affinity binding of [3H]muscimol to cerebral synaptic membranes of scrapie-infected mice.
Topics: Animals; Brain; Flunitrazepam; gamma-Aminobutyric Acid; Mice; Mice, Inbred C57BL; Muscimol; Oxazoles; Receptors, Cell Surface; Receptors, GABA-A; Scrapie; Sheep; Synaptic Membranes | 1984 |
Multiple embryonic benzodiazepine binding sites: evidence for functionality.
Topics: Animals; Benzodiazepines; Binding, Competitive; Brain; Chick Embryo; Electrophysiology; Flunitrazepam; gamma-Aminobutyric Acid; Neurons; Photochemistry; Receptors, Cell Surface; Receptors, GABA-A; Spinal Cord | 1983 |
Benzodiazepine receptor binding in cerebellar cortex: observations in olivopontocerebellar atrophy.
Topics: Atrophy; Benzodiazepines; Brain; Brain Diseases; Cerebellar Cortex; Cerebellum; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Olivary Nucleus; Pedigree; Pons; Receptors, Cell Surface; Receptors, GABA-A | 1984 |
Ethanol and the gamma-aminobutyric acid-benzodiazepine receptor complex.
Topics: Animals; Benzodiazepinones; Brain; Carbolines; Ethanol; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Male; Membranes; Muscimol; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Temperature | 1984 |
Chronic chlordiazepoxide treatment on adult and newborn rats: effect on the GABA-benzodiazepine receptor complex.
Topics: Aging; Animals; Animals, Newborn; Chlordiazepoxide; Female; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1983 |
Chronic administration of the GABA-transaminase inhibitor ethanolamine O-sulphate leads to up-regulation of GABA binding sites.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain Chemistry; Ethanolamines; Flunitrazepam; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1984 |
A gamma-aminobutyric acid/benzodiazepine receptor complex from bovine cerebral cortex. Improved purification with preservation of regulatory sites and their interactions.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Cerebral Cortex; Cholic Acids; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Methods; Muscimol; Pentobarbital; Receptors, Cell Surface; Receptors, GABA-A; Solubility | 1984 |
Photoaffinity labelling of the benzodiazepine receptor compromises the recognition site but not its effector mechanism.
Topics: Affinity Labels; Animals; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Photochemistry; Rats; Receptors, Cell Surface; Receptors, GABA-A; Sodium Chloride; Ultraviolet Rays | 1984 |
Correlations among minimal neurotoxicity, anticonvulsant activity, and displacing potencies in [3H]flunitrazepam binding of benzodiazepines.
Topics: Animals; Benzodiazepines; Flunitrazepam; gamma-Aminobutyric Acid; Male; Mice; Nervous System; Seizures; Tritium | 1983 |
Benzodiazepine ([3H])-flunitrazepam) binding sites in cerebellar and cerebral cortical slices of mouse brain.
Topics: Animals; Benzylamines; Binding Sites; Cerebellar Cortex; Cerebral Cortex; Emotions; Flunitrazepam; gamma-Aminobutyric Acid; Hot Temperature; In Vitro Techniques; Kinetics; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL | 1984 |
Interaction of SQ 20009 and GABA-like drugs as modulators of benzodiazepine receptor binding.
Topics: Animals; Benzodiazepines; Cerebellum; Drug Interactions; Etazolate; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Membranes; Muscimol; Nicotinic Acids; Rats; Receptors, Drug | 1980 |
Serotoninergic control of punished behavior: effects of intra-raphe microinjections of chlordiazepoxide, GABA and 5-HT on behavioral suppression in rats.
Topics: 5,7-Dihydroxytryptamine; Animals; Behavior, Animal; Chlordiazepoxide; Desipramine; Flunitrazepam; gamma-Aminobutyric Acid; Male; Punishment; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin | 1981 |
The benzodiazepine receptor: its development and its modulation by gamma-aminobutyric acid.
Topics: Age Factors; Aminobutyrates; Animals; Benzodiazepines; Bicuculline; Brain Chemistry; Female; Fetus; Flunitrazepam; gamma-Aminobutyric Acid; Mice; Mice, Inbred Strains; Pregnancy; Receptors, Drug | 1980 |
Radiohistochemical localization of benzodiazepine receptors in rat brain.
Topics: Animals; Autoradiography; Benzodiazepines; Brain; Flunitrazepam; gamma-Aminobutyric Acid; Hydrochloric Acid; In Vitro Techniques; Kinetics; Protein Binding; Rats; Receptors, Drug; Time Factors; Tissue Distribution | 1980 |
Solubilization of the benzodiazepine receptor from rat brain.
Topics: Animals; Benzodiazepines; Brain; Catalase; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Membranes; Nerve Tissue Proteins; Rats; Receptors, Drug | 1980 |
Solubilization of gamma-aminobutyric acid receptor from rat brain.
Topics: Animals; Benzodiazepines; Brain; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Membranes; Nerve Tissue Proteins; Rats; Receptors, Drug | 1980 |
NMDA-mediated modulation of gamma-aminobutyric acid type A receptor function in cerebellar granule neurons.
Topics: Animals; Cells, Cultured; Cerebellum; Chlorides; Flunitrazepam; Furosemide; gamma-Aminobutyric Acid; Ion Channel Gating; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Potassium; Potassium Chloride; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Zinc | 1995 |
Lindane cytotoxicity in cultured neocortical neurons is ameliorated by GABA and flunitrazepam.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cell Survival; Cells, Cultured; Cerebral Cortex; Chloride Channels; Chlorine; Convulsants; Flunitrazepam; gamma-Aminobutyric Acid; Hexachlorocyclohexane; Mice; Neurons; Potassium; Receptors, GABA | 1994 |
[Changes in GABAA/benzodiazepine receptor complex function in the pentobarbital-dependent rat. II: Strain differences between Lewis and Wistar-Kyoto rats].
Topics: Animals; Bicuculline; Brain; Chlorine; Ethanol; Female; Flunitrazepam; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Lew; Rats, Inbred WKY; Receptors, GABA-A; Substance-Related Disorders | 1995 |
Central-type benzodiazepine receptors mediate the antidopaminergic effect of clonazepam and melatonin in 6-hydroxydopamine lesioned rats: involvement of a GABAergic mechanism.
Topics: Animals; Apomorphine; Behavior, Animal; Bicuculline; Clonazepam; Corpus Striatum; Dopamine Agonists; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Isoquinolines; Male; Melatonin; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1995 |
The effect of phencyclidine on [3H]GABA and [3H]flunitrazepam binding in the brain of naive and handling-habituated rats.
Topics: Animals; Brain; Corpus Striatum; Flunitrazepam; Frontal Lobe; gamma-Aminobutyric Acid; Handling, Psychological; Kinetics; Male; Phencyclidine; Rats; Rats, Sprague-Dawley | 1995 |
Pharmacology of GABA receptor Cl- channels in rat retinal bipolar cells.
Topics: Animals; Animals, Newborn; Bicuculline; Cells, Cultured; Chloride Channels; Flunitrazepam; gamma-Aminobutyric Acid; Ion Channels; Membrane Potentials; Membrane Proteins; Neurons; Pentobarbital; Photoreceptor Cells; Picrotoxin; Pregnanediones; Rats; Receptors, GABA-A; Sesterterpenes; Strychnine | 1993 |
Allosteric modulation of the GABA-induced chloride current in frog melanotrophs.
Topics: Action Potentials; Allosteric Regulation; Animals; Anti-Anxiety Agents; Azepines; Benzodiazepinones; Chloride Channels; Convulsants; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; Ion Channels; Melanocyte-Stimulating Hormones; Membrane Proteins; Pituitary Gland; Ranidae; Receptors, GABA-A | 1993 |
GABAA receptor-mediated inhibition of N-methyl-D-aspartate-evoked [3H]dopamine release from mesencephalic cell cultures.
Topics: Animals; Baclofen; Cells, Cultured; Dopamine; Flunitrazepam; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Kainic Acid; Mesencephalon; Muscimol; N-Methylaspartate; Picrotoxin; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, GABA; Ventral Tegmental Area | 1994 |
Synthesis of some 2-aryl-1,2,4-triazolo[1,5-c][1,3]benzoxazin-5-ones as tools to define the essential pharmacophoric descriptors of a benzodiazepine receptor ligand.
Topics: Animals; Brain; Cattle; Flunitrazepam; gamma-Aminobutyric Acid; Ligands; Oxazines; Receptors, GABA-A; Structure-Activity Relationship | 1995 |
Interaction between [3H]flunitrazepam and [3H]GABA binding in the cerebellum of reeler mice.
Topics: Animals; Binding, Competitive; Carrier Proteins; Cerebellum; Flunitrazepam; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Isoquinolines; Membrane Proteins; Membrane Transport Proteins; Mice; Mice, Neurologic Mutants; Models, Neurological; Nerve Tissue Proteins; Organic Anion Transporters; Protein Binding; Receptors, GABA-A; Up-Regulation | 1995 |
Modulation by extracellular pH of the activity of GABAA receptors on rat cerebellum granule cells.
Topics: Animals; Cells, Cultured; Cerebellum; Chloride Channels; Electrophysiology; Extracellular Space; Flunitrazepam; gamma-Aminobutyric Acid; Hydrogen-Ion Concentration; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, GABA-A | 1994 |
Selective actions of certain neuroactive pregnanediols at the gamma-aminobutyric acid type A receptor complex in rat brain.
Topics: Animals; Binding Sites; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Flunitrazepam; gamma-Aminobutyric Acid; Humans; In Vitro Techniques; Male; Pregnanediol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1995 |
Immunohistochemical and neurochemical evidence for GABAA receptor heterogeneity between the hypothalamus and cortex.
Topics: Animals; Cerebral Cortex; Chlorides; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; Hypothalamus; Male; Rats; Receptors, GABA-A | 1994 |
Hypothalamic GABAA receptor blockade modulates cerebral cortical systems sensitive to acute stressors.
Topics: Animals; Behavior, Animal; Bicuculline; Brain Chemistry; Cerebral Cortex; Chlorides; Dopamine; Flunitrazepam; Frontal Lobe; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hypothalamus; Male; Rats; Stress, Psychological | 1994 |
Heterogeneity of GABAA receptor in goldfish retina.
Topics: Affinity Labels; Animals; Antibodies, Monoclonal; Autoradiography; Cattle; Flunitrazepam; gamma-Aminobutyric Acid; Goldfish; Immunoblotting; Immunohistochemistry; Indicators and Reagents; Molecular Weight; Muscimol; Receptors, GABA-A; Retina; Synaptic Membranes; Synaptic Transmission | 1994 |
Allosteric modulation of [35S]TBPS-binding in the cerebral cortex of the rat during postnatal development.
Topics: Aging; Allosteric Regulation; Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chloride Channels; Convulsants; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Stereoisomerism; Sulfur Radioisotopes | 1994 |
Benzodiazepine treatment causes uncoupling of recombinant GABAA receptors expressed in stably transfected cells.
Topics: Allosteric Site; Animals; Benzodiazepines; Cattle; Cell Line; Clonazepam; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Mice; Receptors, GABA; Recombinant Proteins; Transfection | 1994 |
Cloning and functional expression of a Drosophila gamma-aminobutyric acid receptor.
Topics: Amino Acid Sequence; Animals; Base Sequence; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cloning, Molecular; Convulsants; DNA Primers; DNA, Complementary; Drosophila melanogaster; Female; Flunitrazepam; gamma-Aminobutyric Acid; Gene Expression; Macromolecular Substances; Molecular Sequence Data; Muscimol; Oocytes; Pentobarbital; Picrotoxin; Polymerase Chain Reaction; Receptors, GABA; Receptors, GABA-A; Transcription, Genetic; Xenopus laevis | 1994 |
Characterization of the GABA-induced current in frog pituitary melanotrophs.
Topics: Animals; Anura; Cells, Cultured; Chloride Channels; Electrophysiology; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Melanocyte-Stimulating Hormones; Membrane Potentials; Pituitary Gland; Receptors, GABA-A | 1994 |
Inhibitory and excitatory amino acid neurotransmitter binding sites in cynomolgus monkey (Macaca fascicularis) cervical spinal cord.
Topics: Animals; Autoradiography; Dizocilpine Maleate; Flunitrazepam; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kainic Acid; Macaca fascicularis; Receptors, Amino Acid; Receptors, GABA-A; Receptors, Glutamate; Receptors, Glycine; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord; Strychnine; Tritium | 1993 |
beta-Lumicolchicine interacts with the benzodiazepine binding site to potentiate GABAA receptor-mediated currents.
Topics: Animals; Benzodiazepines; Binding Sites; Binding, Competitive; Cerebral Cortex; Chlorides; DNA, Complementary; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Kinetics; Lumicolchicines; Mice; Mice, Inbred ICR; Oocytes; Receptors, GABA-A; Xenopus laevis | 1994 |
The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit.
Topics: Allosteric Site; Amino Acid Sequence; Animals; Anticonvulsants; Base Sequence; DNA Primers; DNA, Complementary; Dose-Response Relationship, Drug; Female; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Macromolecular Substances; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Point Mutation; Polymerase Chain Reaction; Receptors, GABA-A; Recombinant Fusion Proteins; Triazoles; Xenopus | 1994 |
GABAergic and dopaminergic transmission in the brain of Roman high-avoidance and Roman low-avoidance rats.
Topics: Amygdala; Animals; Avoidance Learning; Benzazepines; Binding Sites; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebral Cortex; Chlorides; Convulsants; Corpus Striatum; Dopamine; Emotions; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Kinetics; Male; Nucleus Accumbens; Organ Specificity; Prefrontal Cortex; Rats; Rats, Mutant Strains; Receptors, Dopamine D1; Species Specificity; Synaptic Transmission | 1994 |
Hippocampal benzodiazepine receptors in schizophrenia.
Topics: Aged; Female; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Humans; In Vitro Techniques; Kinetics; Male; Receptors, GABA-A; Schizophrenia; Up-Regulation | 1993 |
Further evidence for a functional dorsal-ventral division of the rat striatum: GABAergic involvement in oral movements.
Topics: Animals; Apomorphine; Behavior, Animal; Benzamides; Benzazepines; Carbachol; Corpus Striatum; Dopamine; Flunitrazepam; gamma-Aminobutyric Acid; Jaw; Male; Muscimol; N-Methylscopolamine; Picrotoxin; Pilocarpine; Rats; Rats, Sprague-Dawley; Scopolamine Derivatives | 1993 |
Zinc selectively inhibits flux through benzodiazepine-insensitive gamma-aminobutyric acid chloride channels in cortical and cerebellar microsacs.
Topics: Animals; Benzodiazepines; Cerebellum; Cerebral Cortex; Chloride Channels; Chlorides; Chlorine; Drug Synergism; Flumazenil; Flunitrazepam; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Kinetics; Radioisotopes; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Stimulation, Chemical; Tritium; Zinc | 1993 |
Effects of cell signaling on the development of GABA receptors in chick retina neurons.
Topics: Animals; Antibodies, Monoclonal; Cell Communication; Cell Differentiation; Cells, Cultured; Chick Embryo; Flunitrazepam; gamma-Aminobutyric Acid; Insulin; Membrane Proteins; Radioligand Assay; Receptors, GABA-A; Retina; Signal Transduction | 1993 |
Anticonvulsant doses of 2-chloro-N6-cyclopentyladenosine, an adenosine A1 receptor agonist, reduce GABAergic transmission in different areas of the mouse brain.
Topics: Adenosine; Animals; Anticonvulsants; Behavior, Animal; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Convulsants; Depression, Chemical; Diazepam; Dose-Response Relationship, Drug; Flunitrazepam; gamma-Aminobutyric Acid; Isoniazid; Male; Mice; Mice, Inbred Strains; Purinergic P1 Receptor Antagonists; Receptors, GABA; Receptors, Purinergic P1; Seizures; Sulfur Radioisotopes; Synaptic Transmission; Tritium; Xanthines | 1993 |
Postnatal development and GABA allosteric modulation of benzodiazepine receptor binding in the vitamin B-6 deficient rat brain.
Topics: Aging; Allosteric Regulation; Animals; Brain; Cell Membrane; Cerebellum; Cerebral Cortex; Female; Flunitrazepam; gamma-Aminobutyric Acid; Male; Neurons; Rats; Receptors, GABA-A; Vitamin B 6 Deficiency | 1993 |
Housing conditions alter GABAA receptor of alcohol-preferring and -nonpreferring rats.
Topics: Alcohol Drinking; Animals; Chlorine; Flunitrazepam; gamma-Aminobutyric Acid; Male; Radioisotopes; Rats; Receptors, GABA-A; Social Isolation | 1993 |
Solubilization of benzodiazepine receptors from long- and short-sleep mice.
Topics: Animals; Cerebral Cortex; Cholic Acids; Deoxycholic Acid; Ethanol; Female; Flunitrazepam; gamma-Aminobutyric Acid; Glucosides; In Vitro Techniques; Mice; Receptors, GABA-A; Sleep | 1993 |
Bicuculline-produced regional differences in the modulation of 35S-TBPS binding by GABA, pentobarbital and diazepam in mouse cerebellum and cortex.
Topics: Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Phenobarbital; Receptors, GABA-A | 1993 |
The influence of the gamma 2L subunit on the modulation of responses to GABAA receptor activation.
Topics: Anesthetics; Animals; Fibroblasts; Flunitrazepam; gamma-Aminobutyric Acid; L Cells; Mice; Pentobarbital; Pregnanediones; Receptors, GABA-A; Recombinant Proteins; Transfection | 1993 |
Full and partial agonism displayed by benzodiazepine receptor ligands at recombinant gamma-aminobutyric acidA receptor subtypes.
Topics: Benzodiazepinones; Carbolines; Cells, Cultured; DNA; Drug Synergism; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Imidazoles; Kinetics; Ligands; Macromolecular Substances; Pyrimidines; Receptors, GABA-A; Recombinant Proteins; Sensitivity and Specificity; Substrate Specificity; Transfection | 1993 |
GABAA receptor subtypes: ligand binding heterogeneity demonstrated by photoaffinity labeling and autoradiography.
Topics: Affinity Labels; Animals; Autoradiography; Brain; Flunitrazepam; gamma-Aminobutyric Acid; Muscimol; Rats; Receptors, GABA-A; Tissue Distribution | 1993 |
Autoradiographical study of types 1 and 2 of benzodiazepine receptors in rat brain after chronic ethanol treatment and its withdrawal.
Topics: Animals; Autoradiography; Brain; Ethanol; Flunitrazepam; gamma-Aminobutyric Acid; Male; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A; Substance Withdrawal Syndrome | 1995 |
Allosteric modulation of [3H]flunitrazepam binding to recombinant GABAA receptors.
Topics: Allosteric Regulation; Animals; Binding, Competitive; Cell Line; Cerebellum; Dose-Response Relationship, Drug; Etomidate; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Kidney; Pentobarbital; Radioligand Assay; Rats; Receptors, GABA-A | 1995 |
Biochemical evaluations of the effects of loreclezole and propofol on the GABAA receptor in rat brain.
Topics: Anesthetics; Animals; Anticonvulsants; Brain; Bridged Bicyclo Compounds, Heterocyclic; Diazepam; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Hypnotics and Sedatives; In Vitro Techniques; Male; Muscimol; Pentobarbital; Pregnanediones; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sulfur Radioisotopes; Triazoles; Tritium | 1996 |
Cloning of cDNAs encoding the human gamma-aminobutyric acid type A receptor alpha 6 subunit and characterization of the pharmacology of alpha 6-containing receptors.
Topics: Amino Acid Sequence; Animals; Antisense Elements (Genetics); Autoradiography; Base Sequence; Cerebellar Cortex; Cloning, Molecular; DNA Primers; DNA, Complementary; Female; Flunitrazepam; gamma-Aminobutyric Acid; Humans; In Situ Hybridization; Kinetics; L Cells; Ligands; Macromolecular Substances; Membrane Potentials; Mice; Molecular Sequence Data; Oocytes; Pentobarbital; Polymerase Chain Reaction; Pregnanolone; Rats; Receptors, GABA-A; Recombinant Proteins; RNA, Messenger; Sequence Homology, Amino Acid; Transfection; Xenopus laevis | 1996 |
6-Bromoflavone, a high affinity ligand for the central benzodiazepine receptors is a member of a family of active flavonoids.
Topics: Affinity Labels; Analysis of Variance; Animals; Anti-Anxiety Agents; Flavonoids; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Maze Learning; Mice; Molecular Structure; Motor Activity; Receptors, GABA-A; Structure-Activity Relationship | 1996 |
Differences in benzodiazepine binding in quail selectively bred for differences in tonic immobility.
Topics: Animals; Anti-Anxiety Agents; Azides; Benzodiazepines; Brain; Chlorine; Coturnix; Diazepam; Ethanol; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Motor Activity; Radioisotopes; Receptors, GABA-A | 1996 |
GABAA receptor binding in the aging rat inferior colliculus.
Topics: Aged; Aging; Animals; Autoradiography; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Inferior Colliculi; Ligands; Muscimol; Picrotoxin; Rats; Rats, Inbred F344; Receptors, GABA-A; Tritium | 1996 |
The neurochemical pathology of thiamine deficiency: GABAA and glutamateNMDA receptor binding sites in a goat model.
Topics: Alcoholism; Amprolium; Animals; Brain Chemistry; Diazepam; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Goats; In Vitro Techniques; Male; Muscimol; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes; Synaptosomes; Thiamine Deficiency | 1996 |
Molecular mechanisms of benzodiazepine-induced down-regulation of GABAA receptor alpha 1 subunit protein in rat cerebellar granule cells.
Topics: Animals; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Gene Expression; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Staurosporine | 1996 |
The enhancement of muscimol-stimulated 36C1 influx by the antispastic 5-aryl-3-(alkylsulfonyl)-4H-1,2,4-triazole (MDL 27,531) in rat brain membrane vesicles.
Topics: Animals; Brain Chemistry; Chloride Channels; Chlorine; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Ion Channel Gating; Male; Membranes; Muscimol; Radioisotopes; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Triazoles | 1995 |
gamma-aminobutyric acidA receptor regulation: heterologous uncoupling of modulatory site interactions induced by chronic steroid, barbiturate, benzodiazepine, or GABA treatment in culture.
Topics: Animals; Barbiturates; Benzodiazepines; Binding, Competitive; Cells, Cultured; Chick Embryo; Dose-Response Relationship, Drug; Flunitrazepam; gamma-Aminobutyric Acid; Radioligand Assay; Receptors, GABA-A; Steroids | 1996 |
Diazepam physical dependence and withdrawal in rats is associated with alteration in GABAA receptor function.
Topics: Animals; Benzodiazepines; Cerebral Cortex; Chloride Channels; Chlorides; Diazepam; Flumazenil; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred F344; Receptors, GABA-A; Substance Withdrawal Syndrome; Substance-Related Disorders | 1996 |
Age-related modifications on the GABAA receptor binding properties from Wistar rat prefrontal cortex.
Topics: Aging; Animals; Benzodiazepines; Binding Sites; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Male; Muscimol; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, GABA-A | 1996 |
Receptor binding sites and uptake activities mediating GABA neurotransmission in chronic alcoholics with Wernicke encephalopathy.
Topics: Adult; Aged; Aged, 80 and over; Alcoholism; Binding Sites; Diazepam; Female; Fibrosis; Flunitrazepam; Frontal Lobe; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Motor Cortex; Muscimol; Receptors, GABA; Synaptic Transmission; Wernicke Encephalopathy | 1996 |
Is upregulation of benzodiazepine receptors a compensatory reaction to reduced GABAergic tone in the brain of stressed mice?
Topics: Animals; Brain; Chlorides; Flunitrazepam; gamma-Aminobutyric Acid; Male; Mice; Muscimol; Receptors, GABA-A; Stress, Physiological; Thiopental; Up-Regulation | 1996 |
Granule cell disinhibition in dentate gyrus of genetically seizure susceptible El mice.
Topics: Aging; Animals; Anticonvulsants; Bicuculline; Chromatography, High Pressure Liquid; Dentate Gyrus; Electrophysiology; Flunitrazepam; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Phenobarbital; Seizures | 1997 |
Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit.
Topics: Amino Acid Sequence; Anesthetics, Intravenous; Animals; Bicuculline; Brain; Cell Line; Consensus Sequence; DNA, Complementary; Flumazenil; Flunitrazepam; GABA Agents; gamma-Aminobutyric Acid; Humans; Molecular Sequence Data; Muscimol; Pentobarbital; Picrotoxin; Pregnanolone; Propofol; Rats; Receptors, GABA-A; Recombinant Proteins; RNA, Messenger; Transfection | 1997 |
Allosteric interactions between gamma-aminobutyric acid, benzodiazepine and picrotoxinin binding sites in primary cultures of cerebellar granule cells. Differential effects induced by gamma- and delta-hexachlorocyclohexane.
Topics: Animals; Bicuculline; Cells, Cultured; Cerebellum; Flunitrazepam; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Hexachlorocyclohexane; Isomerism; Kinetics; Rats; Receptors, GABA-A | 1997 |
Daily variations in GABA receptor function in Syrian hamster cerebral cortex.
Topics: Animals; Cerebral Cortex; Chloride Channels; Circadian Rhythm; Cricetinae; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Kinetics; Male; Mesocricetus; Muscimol; Receptors, GABA-A | 1995 |
Potentiation by ethanol of GABA-induced current and facilitation of its desensitization in cultured rat cortical neurons.
Topics: Animals; Cells, Cultured; Central Nervous System Depressants; Cerebral Cortex; Drug Synergism; Ethanol; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, GABA-A | 1997 |
Diazepam-insensitive GABAA receptors on postnatal spiral ganglion neurones in culture.
Topics: Animals; Animals, Newborn; Baclofen; Bicuculline; Carbolines; Cells, Cultured; Convulsants; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pentobarbital; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA-A; Spiral Ganglion; Zinc | 1997 |
Flunitrazepam has an inverse agonistic effect on recombinant alpha6beta2gamma2-GABAA receptors via a flunitrazepam-binding site.
Topics: Affinity Labels; Azides; Benzodiazepines; Binding Sites; Binding, Competitive; Cell Line; Chloride Channels; Flunitrazepam; GABA Agonists; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Kidney; Kinetics; Macromolecular Substances; Membrane Potentials; Receptors, GABA-A; Recombinant Proteins; Transfection | 1997 |
Measurement of GABAA receptor function in rat cultured cerebellar granule cells by the Cytosensor microphysiometer.
Topics: Animals; Benzodiazepines; Bicuculline; Cell Count; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Flunitrazepam; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Hydrogen-Ion Concentration; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1997 |
Regional densities of benzodiazepine sites in the CNS of alcohol-naive P and NP rats.
Topics: Alcohol Drinking; Animals; Autoradiography; Benzodiazepines; Brain; Flunitrazepam; gamma-Aminobutyric Acid; Male; Rats; Receptors, GABA-A | 1997 |
In vivo administration of the 5-HT1A receptor agonist 8-OH-DPAT interferes with brain GABA(A)/benzodiazepine receptor complexes.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cerebral Cortex; Chlorides; Diazepam; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; Male; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Synaptosomes | 1997 |
Frequency-dependent actions of benzodiazepines on GABAA receptors in cultured murine cerebellar granule cells.
Topics: Animals; Benzodiazepines; Cells, Cultured; Cerebellum; Electric Stimulation; Electrophysiology; Flunitrazepam; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Kinetics; Membrane Potentials; Mice; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Receptors, GABA-A | 1997 |
[3H]RY 80: A high-affinity, selective ligand for gamma-aminobutyric acidA receptors containing alpha-5 subunits.
Topics: Alkynes; Animals; Anticonvulsants; Benzodiazepines; Cerebral Cortex; Female; Flunitrazepam; gamma-Aminobutyric Acid; Imidazoles; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Recombinant Proteins | 1997 |
Pharmacology of skeletal muscle GABA-gated chloride channels in the cockroach Periplaneta americana.
Topics: Animals; Bicuculline; Bridged Bicyclo Compounds, Heterocyclic; Chloride Channels; Flunitrazepam; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Ion Channel Gating; Isonicotinic Acids; Male; Motor Neurons; Muscle, Skeletal; Periplaneta; Picrotoxin; Receptors, GABA; Sesterterpenes | 1997 |
Clathrin-coated vesicles from bovine brain contain uncoupled GABAA receptors.
Topics: Allosteric Site; Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Cerebral Cortex; Chloride Channels; Clathrin; Coated Vesicles; Convulsants; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Ligands; Pyridazines; Receptors, GABA-A; Sulfur Radioisotopes; Synaptic Membranes; Tritium | 1997 |
Diazepam enhancement of GABA-gated currents in binary and ternary GABAA receptors: relationship to benzodiazepine binding site density.
Topics: Animals; Benzodiazepines; Binding Sites; Cell Line; Chloride Channels; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Kidney; Membrane Potentials; Radioligand Assay; Rats; Receptors, GABA-A | 1997 |
Voltage-dependent deactivation and desensitization of GABA responses in cultured murine cerebellar granule cells.
Topics: Animals; Cerebellum; Dose-Response Relationship, Drug; Electric Conductivity; Electric Stimulation; Evoked Potentials; Excitatory Postsynaptic Potentials; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Ion Channels; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Neurons; Receptors, GABA; Receptors, GABA-A; Sensitivity and Specificity | 1998 |
Dentate gyrus basket cell GABAA receptors are blocked by Zn2+ via changes of their desensitization kinetics: an in situ patch-clamp and single-cell PCR study.
Topics: Animals; Dentate Gyrus; Dose-Response Relationship, Drug; Flunitrazepam; GABA Agents; gamma-Aminobutyric Acid; Gene Expression; Ion Channel Gating; Kinetics; Patch-Clamp Techniques; Polymerase Chain Reaction; Rats; Rats, Wistar; Receptors, GABA-A; RNA, Messenger; Zinc | 1998 |
Cytotoxic action of lindane in neocortical GABAergic neurons is primarily mediated by interaction with flunitrazepam-sensitive GABA(A) receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cell Survival; Cells, Cultured; Coloring Agents; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Flunitrazepam; GABA Agonists; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Hexachlorocyclohexane; Insecticides; Mice; Mitochondria; Neocortex; Neurons; Receptors, GABA-A; Tetrazolium Salts; Thiazoles; Time Factors | 1998 |
Ethanol selectively enhances the hyperpolarizing component of neocortical neuronal responses to locally applied GABA.
Topics: Animals; Central Nervous System Depressants; Electrophysiology; Ethanol; Flunitrazepam; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Male; Membrane Potentials; Neocortex; Neurons; Pentobarbital; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Synapses | 1998 |
Role of GABA in the actions of ethanol in rats selectively bred for ethanol sensitivity.
Topics: Alcoholic Intoxication; Animals; Behavior, Animal; Central Nervous System Depressants; Chlorides; Ethanol; Female; Flunitrazepam; GABA Agents; gamma-Aminobutyric Acid; Male; Rats; Receptors, GABA; Sleep; Time Factors | 1998 |
Detection of benzodiazepine receptor ligands in small libraries of flavone derivatives synthesized by solution phase combinatorial chemistry.
Topics: Animals; Binding, Competitive; Cell Membrane; Cerebellum; Cerebral Cortex; Chromatography, High Pressure Liquid; Flavonoids; Flunitrazepam; gamma-Aminobutyric Acid; Mice; Molecular Structure; Rats; Receptors, GABA-A; Solutions | 1998 |
Gamma-aminobutyric acidA receptor function is desensitised in rat cultured cerebellar granule cells following chronic flunitrazepam treatment.
Topics: Acids; Animals; Cells, Cultured; Cerebellum; Drug Synergism; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Neurons; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Time Factors | 1998 |
Functional GABA(A) receptors on human glioma cells.
Topics: Anti-Bacterial Agents; Calcium; Calcium Channel Blockers; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Glioblastoma; Gramicidin; Humans; Membrane Potentials; Muscimol; Oligodendroglioma; Patch-Clamp Techniques; Picrotoxin; Potassium; Receptors, GABA-A; Tumor Cells, Cultured; Verapamil | 1998 |
Decreased benzodiazepine binding with little effect on gamma-aminobutyric acid binding in rat brain after treatment with antisense oligodeoxynucleotide to the gamma-aminobutyric acidA receptor gamma-2 subunit.
Topics: Animals; Base Sequence; Benzodiazepines; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Flunitrazepam; gamma-Aminobutyric Acid; Male; Muscimol; Oligonucleotides, Antisense; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Tritium; Xanthines | 1998 |
Benzodiazepine modulation of recombinant alpha1beta3gamma2 GABA(A) receptor function efficacy determination using the Cytosensor microphysiometer.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Biosensing Techniques; Cell Count; Cells, Cultured; Dose-Response Relationship, Drug; Eukaryotic Cells; Flumazenil; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Humans; Pyridines; Receptors, GABA-A; Recombinant Proteins; Time Factors; Zolpidem | 1998 |
Septohippocampal adaptive GABAergic responses by AF64A treatment.
Topics: 4-Aminobutyrate Transaminase; Adaptation, Physiological; Animals; Aziridines; Binding, Competitive; Choline; Choline O-Acetyltransferase; Chromatography, High Pressure Liquid; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; Injections, Intraventricular; Kinetics; Neuromuscular Blocking Agents; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Septal Nuclei | 1999 |
Neurosteroid modulation of the GABAA receptor in the developing guinea pig cerebral cortex.
Topics: Animals; Benzodiazepines; Binding, Competitive; Brain Chemistry; Cerebral Cortex; Female; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Guinea Pigs; Hypnotics and Sedatives; Male; Muscimol; Organ Size; Pregnanolone; Pyridines; Radioligand Assay; Receptors, GABA-A; Tritium; Zolpidem | 1999 |
Modulation of GABA(A) receptor function by neuroactive steroids: evidence for heterogeneity of steroid sensitivity of recombinant GABA(A) receptor isoforms.
Topics: Animals; Dose-Response Relationship, Drug; Female; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Humans; Pregnanediones; Pregnanolone; Protein Isoforms; Receptors, GABA-A; Recombinant Proteins; Steroids; Xenopus laevis | 1998 |
Decreased GABA enhancement of benzodiazepine binding after a single dose of diazepam.
Topics: Animals; Benzodiazepines; Cerebellum; Cerebral Cortex; Diazepam; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Homeostasis; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Time Factors | 1999 |
Acute pentylenetetrazol injection reduces rat GABAA receptor mRNA levels and GABA stimulation of benzodiazepine binding with No effect on benzodiazepine binding site density.
Topics: Animals; Autoradiography; Brain; Down-Regulation; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Male; Muscimol; Pentylenetetrazole; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Time Factors; Transcription, Genetic; Tritium | 1999 |
Effects of the conformationally restricted GABA analogues, cis- and trans-4-aminocrotonic acid, on GABA neurotransmission in primary neuronal cultures.
Topics: Animals; Binding Sites; Cells, Cultured; Cerebellum; Chlorine; Crotonates; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Neocortex; Rats; Receptors, GABA-A; Receptors, Presynaptic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stereoisomerism | 1999 |
Bicuculline-resistant, Cl- dependent GABA response in the rat spinal dorsal horn.
Topics: Animals; Bicuculline; Chloride Channels; Evoked Potentials; Flunitrazepam; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Male; Neurons; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, GABA; Substantia Gelatinosa; Thiopental | 1999 |
Chronic D1 and D2 dopaminomimetic treatment of MPTP-denervated monkeys: effects on basal ganglia GABA(A)/benzodiazepine receptor complex and GABA content.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Autoradiography; Basal Ganglia; Benzazepines; Cabergoline; Denervation; Dopamine Agonists; Ergolines; Female; Flunitrazepam; gamma-Aminobutyric Acid; Macaca fascicularis; Ovariectomy; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, GABA-A; Tritium | 1999 |
[(3)H]-girisopam, a novel selective benzodiazepine for the 2, 3-benzodiazepine binding site.
Topics: Adult; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Benzodiazepines; Binding Sites; Binding, Competitive; Corpus Striatum; Diazepam; Dopamine; Flunitrazepam; gamma-Aminobutyric Acid; Glutamine; Humans; Male; Organ Specificity; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Serotonin; Structure-Activity Relationship | 1999 |
Junctional versus extrajunctional glycine and GABA(A) receptor-mediated IPSCs in identified lamina I neurons of the adult rat spinal cord.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Evoked Potentials; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Male; Neurons; Patch-Clamp Techniques; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glycine; Spinal Cord; Strychnine; Sucrose; Tetrodotoxin | 1999 |
The GABA(A) receptor complex as a target for fluoxetine action.
Topics: Animals; Chlorides; Dose-Response Relationship, Drug; Flunitrazepam; Fluoxetine; gamma-Aminobutyric Acid; Ion Transport; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Selective Serotonin Reuptake Inhibitors; Tritium | 1999 |
Effects of Valeriana officinalis extracts on [3H]flunitrazepam binding, synaptosomal [3H]GABA uptake, and hippocampal [3H]GABA release.
Topics: Animals; Drug Synergism; Female; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; Medicine, Traditional; Mice; Plant Extracts; Plants, Medicinal; Potassium; Rats; Rats, Sprague-Dawley; Synaptosomes; Tritium; Veratridine | 1999 |
Effects of treatment with GABA(A) receptor subunit antisense oligodeoxynucleotides on GABA-stimulated 36Cl- influx in the rat cerebral cortex.
Topics: Animals; Base Sequence; Bicuculline; Cerebral Cortex; Chlorides; Flunitrazepam; gamma-Aminobutyric Acid; Male; Oligodeoxyribonucleotides, Antisense; Open Reading Frames; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction | 2000 |
Honokiol and magnolol increase the number of [3H] muscimol binding sites three-fold in rat forebrain membranes in vitro using a filtration assay, by allosterically increasing the affinities of low-affinity sites.
Topics: Allosteric Regulation; Androstanes; Animals; Azasteroids; Binding Sites; Biphenyl Compounds; Cell Membrane; Central Nervous System Depressants; Cerebellum; Diflunisal; Drugs, Chinese Herbal; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Kinetics; Lignans; Muscimol; Picrotoxin; Propofol; Prosencephalon; Rats; Receptors, GABA-A; Tritium | 1999 |
Evidence of two populations of GABA(A) receptors in cerebellar granule cells in culture: different desensitization kinetics, pharmacology, serine/threonine kinase sensitivity, and localization.
Topics: Animals; Cells, Cultured; Cerebellum; Down-Regulation; Enzyme Inhibitors; Flunitrazepam; gamma-Aminobutyric Acid; Hydrogen-Ion Concentration; Kinetics; N-Methylaspartate; Patch-Clamp Techniques; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate | 1999 |
Neocortical hyperexcitability after GABA withdrawal in vitro.
Topics: Animals; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Muscimol; Neocortex; Pregnanolone; Progesterone; Rats; Rats, Wistar; Seizures; Substance Withdrawal Syndrome; Synaptic Transmission | 2000 |
Postsynaptic receptor occupancy during evoked transmission at striatal GABAergic synapses in vitro.
Topics: Animals; Cells, Cultured; Corpus Striatum; Electrophysiology; Female; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Channel Gating; Models, Molecular; Neural Inhibition; Neurons; Pregnancy; Rats; Rats, Wistar; Reaction Time; Receptors, GABA; Synapses; Synaptic Transmission | 2000 |
GABA(B) receptors are the first target of released GABA at lamina I inhibitory synapses in the adult rat spinal cord.
Topics: Age Factors; Animals; Benzylamines; Bicuculline; Flunitrazepam; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Glycine Agents; Male; Membrane Potentials; Neural Inhibition; Patch-Clamp Techniques; Phosphinic Acids; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, GABA-B; Receptors, Glycine; Spinal Cord; Strychnine; Synapses | 2000 |
Allosteric modulation in spontaneously active mutant gamma-aminobutyric acid(A) receptors [corrected].
Topics: Allosteric Regulation; Amino Acid Substitution; Animals; Bicuculline; Cells, Cultured; Female; Flunitrazepam; GABA Agonists; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Mutagenesis, Site-Directed; Oocytes; Pentobarbital; Picrotoxin; Protein Structure, Tertiary; Receptors, GABA-A; Steroids; Xenopus laevis | 2000 |
Heterogeneity of hippocampal GABA(A) receptors: regulation by corticosterone.
Topics: Allosteric Regulation; Animals; Autoradiography; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Corticosterone; Dendrites; Desoxycorticosterone; Drug Implants; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Ligands; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2001 |
[3H]Ro 15-1788 binding sites to brain membrane of the saltwater Mugil cephalus.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Carbolines; Cell Membrane; Chlorides; Diazepam; Female; Fishes; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Imidazoles; Ionophores; Male; Pyridines; Receptors, GABA-A; Synaptosomes; Tritium; Zolpidem | 2001 |
Radioligand binding assays in the drug discovery process: potential pitfalls of high throughput screenings.
Topics: Animals; Binding, Competitive; Caffeine; Central Nervous System Stimulants; Drug Evaluation, Preclinical; Excitatory Amino Acid Agonists; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Kainic Acid; Membranes; Microsomes; Myocardium; Pharmacology; Radioligand Assay; Rats; Rats, Wistar; Ryanodine; Spermine | 2001 |
Regional distribution of benzodiazepine binding sites in the human newborn and infant hypothalamus. A quantitative autoradiographic study.
Topics: Age Factors; Anterior Hypothalamic Nucleus; Anti-Anxiety Agents; Binding Sites; Female; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Hypothalamus; Hypothalamus, Middle; Hypothalamus, Posterior; Infant; Infant, Newborn; Male; Neurons; Radioligand Assay; Receptors, GABA-A; Tritium | 2001 |
Synaptically released neurotransmitter fails to desensitize postsynaptic GABA(A) receptors in cerebellar cultures.
Topics: Action Potentials; Animals; Cells, Cultured; Cerebellar Cortex; Drug Tolerance; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Mice; Nerve Endings; Neurons; Patch-Clamp Techniques; Receptors, GABA-A; Synapses | 2001 |
In ovo chronic neurosteroid treatment affects the function and allosteric interactions of GABA(A) receptor modulatory sites.
Topics: Allosteric Regulation; Animals; Chick Embryo; Chloride Channels; Chlorides; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Ion Transport; Nerve Tissue Proteins; Optic Lobe, Nonmammalian; Pregnanolone; Receptors, GABA-A; Signal Transduction; Specific Pathogen-Free Organisms; Synaptic Membranes; Synaptic Transmission | 2001 |
Distinct signal transduction pathways for GABA-induced GABA(A) receptor down-regulation and uncoupling in neuronal culture: a role for voltage-gated calcium channels.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Anxiety Agents; Brain; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Chick Embryo; Down-Regulation; Excitatory Amino Acid Antagonists; Flunitrazepam; gamma-Aminobutyric Acid; Membrane Potentials; Neurons; Nifedipine; Potassium; Quinoxalines; Receptors, GABA-A; Signal Transduction; Tetrodotoxin; Tritium | 2001 |
Mutagenesis of the GABA(A) receptor alpha1 subunit reveals a domain that affects sensitivity to GABA and benzodiazepine-site ligands.
Topics: Allosteric Regulation; Benzodiazepines; Binding Sites; Electric Conductivity; Electrophysiology; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Ion Channel Gating; Mutagenesis; Protein Structure, Tertiary; Protein Subunits; Receptors, GABA-A; Structure-Activity Relationship | 2001 |
Mercury interaction with the GABA(A) receptor modulates the benzodiazepine binding site in primary cultures of mouse cerebellar granule cells.
Topics: Alkylation; Animals; Anti-Anxiety Agents; Antioxidants; Binding Sites; Cells, Cultured; Cerebellum; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flunitrazepam; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Ion Channels; Mercuric Chloride; Mercury Compounds; Methylmercury Compounds; Mice; Protein Kinase C; Receptors, GABA-A; Sulfhydryl Compounds | 2001 |
Influence of membrane cholesterol on modulation of the GABA(A) receptor by neuroactive steroids and other potentiators.
Topics: Animals; Cell Membrane; Cholesterol; Dose-Response Relationship, Drug; Drug Synergism; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pentobarbital; Pregnanolone; Pregnenolone; Propofol; Rats; Rats, Wistar; Receptors, GABA-A | 2001 |
Evidence for the formation of functionally distinct alphabetagammaepsilon GABA(A) receptors.
Topics: Anesthetics, Intravenous; Cell Line; Drug Synergism; Electric Conductivity; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Humans; Ion Channels; Propofol; Protein Isoforms; Receptors, GABA-A | 2001 |
Binding and neuropharmacological profile of zaleplon, a novel nonbenzodiazepine sedative/hypnotic.
Topics: Acetamides; Animals; Benzodiazepinones; Electroencephalography; Flunitrazepam; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Male; Muscimol; Pyrimidines; Rabbits; Rats; Rats, Sprague-Dawley; Sleep | 2002 |
Modulation of radioligand binding to the GABA(A)-benzodiazepine receptor complex by a new component from Cyperus rotundus.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Cyperaceae; Flumazenil; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Plant Extracts; Plant Roots; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sesquiterpenes | 2002 |
Plasticity of GABA(a) system during ageing: focus on vestibular compensation and possible pharmacological intervention.
Topics: Adaptation, Physiological; Aging; Animals; Brain; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Male; Neuronal Plasticity; Nicergoline; Nootropic Agents; Postural Balance; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Recovery of Function; RNA, Messenger; Synaptic Transmission; Vestibular Diseases; Vestibule, Labyrinth | 2002 |
Mechanism of alpha-subunit selectivity of benzodiazepine pharmacology at gamma-aminobutyric acid type A receptors.
Topics: Animals; Anti-Anxiety Agents; Binding, Competitive; Cell Line; Diazepam; Dose-Response Relationship, Drug; Female; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Membrane Potentials; Mutation; Oocytes; Protein Subunits; Pyridazines; Pyridines; Radioligand Assay; Receptors, GABA-A; Tritium; Xenopus laevis; Zolpidem | 2002 |
Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy.
Topics: Amino Acid Substitution; Animals; Anti-Anxiety Agents; Cell Line; Diazepam; Epilepsy; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Kinetics; Membrane Potentials; Mutagenesis, Site-Directed; Neurons; Oocytes; Patch-Clamp Techniques; Protein Subunits; Pyridines; Receptors, GABA-A; Recombinant Proteins; Synapses; Synaptic Transmission; Transfection; Xenopus; Zolpidem | 2002 |
GABA(A) receptor sites in the developing human foetus.
Topics: Adult; Aged; Binding Sites; Cell Differentiation; Cerebral Cortex; Diazepam; Female; Fetus; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Infant; Infant, Newborn; Male; Middle Aged; Neural Inhibition; Neurons; Pregnancy; Protein Subunits; Radioligand Assay; Receptors, GABA-A | 2002 |
Modulation of [3H] TBOB binding to the rodent GABAA receptor by simple disaccharides.
Topics: Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebellum; Drug Interactions; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Glycosylation; Lactose; Male; Prosencephalon; Rats; Rats, Wistar; Receptors, GABA-A; Tritium | 2003 |
Distribution and binding parameters of GABAA receptors in the thalamic nuclei of Macaca mulatta and changes caused by lesioning in the globus pallidus and reticular thalamic nucleus.
Topics: Animals; Autoradiography; Basal Ganglia; Binding, Competitive; Denervation; Excitatory Amino Acid Agonists; Female; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Globus Pallidus; Ibotenic Acid; Kainic Acid; Macaca mulatta; Male; Muscimol; Neural Pathways; Receptors, GABA-A; Thalamic Nuclei; Time Factors; Tritium | 2003 |
CCK-8 modulates GABA-stimulated [3H]-flunitrazepam binding in vitro.
Topics: Animals; Brain; Cell Membrane; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Male; Rats; Rats, Wistar; Receptors, GABA-A; Sincalide | 2003 |
Testosterone treatment induces behavioral disinhibition in adult male rats.
Topics: Androgens; Animals; Behavior, Animal; Central Nervous System Depressants; Chlorides; Dose-Response Relationship, Drug; Drinking; Drug Implants; Electroshock; Ethanol; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Genitalia, Male; In Vitro Techniques; Inhibition, Psychological; Male; Motivation; Organ Size; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Synaptosomes; Testosterone | 2003 |
Allopregnanolone-stimulated GABA-mediated chloride ion flux is inhibited by 3beta-hydroxy-5alpha-pregnan-20-one (isoallopregnanolone).
Topics: Animals; Cerebral Cortex; Chlorides; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Osmolar Concentration; Pentobarbital; Pregnanolone; Rats; Rats, Wistar | 2003 |
Deletion of the fyn-kinase gene alters sensitivity to GABAergic drugs: dependence on beta2/beta3 GABAA receptor subunits.
Topics: Animals; Binding Sites; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Gene Deletion; Isoxazoles; Mice; Protein Subunits; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Receptors, GABA-A; Reflex; Tritium | 2004 |
Characterization of a new synthetic isoflavonoid with inverse agonist activity at the central benzodiazepine receptor.
Topics: Analysis of Variance; Animals; Bicuculline; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Female; Flavonoids; Flunitrazepam; GABA Agonists; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Hippocampus; Isoflavones; Kinetics; Male; Membrane Potentials; Midazolam; Neurons; Pregnancy; Rats; Rats, Wistar; Receptors, GABA-A; Synaptosomes; Time Factors; Tritium | 2004 |
Chronic exposure of cells expressing recombinant GABAA receptors to benzodiazepine antagonist flumazenil enhances the maximum number of benzodiazepine binding sites.
Topics: Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cell Membrane; Diazepam; Dose-Response Relationship, Drug; Drug Combinations; Flumazenil; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Humans; Kidney; Ligands; Receptors, GABA-A; Recombinant Proteins; Tritium | 2004 |
Characterization in rats of the anxiolytic potential of ELB139 [1-(4-chlorophenyl)-4-piperidin-1-yl-1,5-dihydro-imidazol-2-on], a new agonist at the benzodiazepine binding site of the GABAA receptor.
Topics: Animals; Anti-Anxiety Agents; Binding Sites; Binding, Competitive; Conflict, Psychological; Diazepam; Drug Tolerance; Flumazenil; Flunitrazepam; GABA Agonists; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Imidazoles; Light; Male; Membrane Potentials; Patch-Clamp Techniques; Piperidines; Rats; Rats, Wistar | 2005 |
Ethyl 2-(4-bromophenyl)-1-(2,4-dichlorophenyl)-1H-4-imidazolecarboxylate is a novel positive modulator of GABAA receptors.
Topics: Animals; Binding, Competitive; Cell Membrane; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Etomidate; Female; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Glycine; Humans; Hydrocarbons, Halogenated; Imidazoles; Male; Membrane Potentials; Oocytes; Pentobarbital; Pregnanediones; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glycine; Receptors, Serotonin, 5-HT3; Serotonin; Tritium; Xenopus laevis | 2005 |
Differential effects of mild repeated restraint stress on behaviors and GABA(A) receptors in male and female rats.
Topics: Animals; Behavior, Animal; Binding, Competitive; Cerebral Cortex; Chlorides; Corticosterone; Female; Flunitrazepam; gamma-Aminobutyric Acid; Male; Maze Learning; Motor Activity; Ovariectomy; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Restraint, Physical; Seizures; Sex Factors; Stress, Psychological; Tritium | 2005 |
Radioligand binding studies of caloporoside and novel congeners with contrasting effects upon [35S] TBPS binding to the mammalian GABA(A) receptor.
Topics: Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Flunitrazepam; gamma-Aminobutyric Acid; Glucosides; Male; Mannose; Muscimol; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A; Salicylates; Structure-Activity Relationship; Sulfur Radioisotopes | 2005 |
Allosteric positive interaction of thymol with the GABAA receptor in primary cultures of mouse cortical neurons.
Topics: Anesthetics, Intravenous; Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Chloride Channels; Computer Simulation; Female; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; L-Lactate Dehydrogenase; Mice; Models, Molecular; Models, Neurological; Muscimol; Neurons; Neurotoxins; Pregnancy; Propidium; Propofol; Receptors, GABA-A; Thymol | 2006 |
Multiple types of GABAA receptors mediate inhibition in brain stem parasympathetic cardiac neurons in the nucleus ambiguus.
Topics: Animals; Brain Stem; Choline O-Acetyltransferase; Efferent Pathways; Electrophysiology; Excitatory Postsynaptic Potentials; Flunitrazepam; GABA Antagonists; GABA Modulators; GABA Plasma Membrane Transport Proteins; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Heart; Immunohistochemistry; In Vitro Techniques; Medulla Oblongata; Neurons; Parasympathetic Nervous System; Patch-Clamp Techniques; Pharyngeal Muscles; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Synaptic Transmission; Vagus Nerve | 2006 |
Allosteric uncoupling and up-regulation of benzodiazepine and GABA recognition sites following chronic diazepam treatment of HEK 293 cells stably transfected with alpha1beta2gamma2S subunits of GABA (A) receptors.
Topics: Allosteric Regulation; Animals; Benzodiazepines; Binding Sites; Binding, Competitive; Cell Line; Diazepam; Flumazenil; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Muscimol; Picrotoxin; Protein Subunits; Pyridazines; Radioligand Assay; Rats; Receptors, GABA-A; Receptors, GABA-B; Transfection; Up-Regulation | 2007 |
Exploring ligand recognition and ion flow in comparative models of the human GABA type A receptor.
Topics: Amino Acid Sequence; Benzodiazepines; Binding Sites; Computer Simulation; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Ligands; Models, Molecular; Molecular Sequence Data; Muscimol; Protein Structure, Secondary; Protein Structure, Tertiary; Receptors, GABA-A; Sequence Homology, Amino Acid | 2007 |
Neonatal maternal separation and enhancement of the hypoxic ventilatory response in rat: the role of GABAergic modulation within the paraventricular nucleus of the hypothalamus.
Topics: Animals; Animals, Newborn; Anxiety, Separation; Female; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Hypoxia; Male; Muscimol; Paraventricular Hypothalamic Nucleus; Pulmonary Ventilation; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Respiratory Mechanics; Synaptic Transmission | 2007 |
CNS 7056: a novel ultra-short-acting Benzodiazepine.
Topics: Animals; Benzodiazepines; Binding, Competitive; Cell Line; Cerebral Cortex; Electrophysiology; Extracellular Space; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Hypnotics and Sedatives; In Vitro Techniques; Ion Channels; Membranes; Mice; Midazolam; Postural Balance; Radioligand Assay; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, GABA-A; Substantia Nigra; Swine; Swine, Miniature; Transfection | 2007 |
Two pools of Triton X-100-insoluble GABA(A) receptors are present in the brain, one associated to lipid rafts and another one to the post-synaptic GABAergic complex.
Topics: Animals; Brain; Cells, Cultured; Detergents; Embryo, Mammalian; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Membrane Microdomains; Membrane Proteins; Microscopy, Electron, Transmission; Neurons; Octoxynol; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Saponins; Subcellular Fractions; Synaptosomes | 2007 |
Postnatal development and kinetics of [3H]gaboxadol binding in rat brain: in vitro homogenate binding and quantitative autoradiography.
Topics: Aging; Animals; Animals, Newborn; Autoradiography; Binding, Competitive; Brain; Brain Chemistry; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Subcellular Fractions | 2007 |
Betulin binds to gamma-aminobutyric acid receptors and exerts anticonvulsant action in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antineoplastic Agents; Betulinic Acid; Bicuculline; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred ICR; Muscle Tonus; Pentacyclic Triterpenes; Postural Balance; Receptors, GABA; Seizures; Triterpenes | 2008 |
A high-throughput functional assay for characterization of gamma-aminobutyric acid(A) channel modulators using cryopreserved transiently transfected cells.
Topics: Carbolines; Cell Culture Techniques; Cell Line; Cell Membrane; Cryopreservation; Diazepam; DNA; Dose-Response Relationship, Drug; Drug Discovery; Flumazenil; Flunitrazepam; Fluorescent Dyes; Fluorobenzenes; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Membrane Potentials; Receptors, GABA-A; Reproducibility of Results; Spectrometry, Fluorescence; Transfection; Triazoles; Tritium | 2008 |
Benzodiazepine modulation of the rat GABAA receptor α4β3γ2L subtype expressed in Xenopus oocytes.
Topics: Animals; Benzodiazepines; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; HEK293 Cells; Humans; Oocytes; Patch-Clamp Techniques; Protein Subunits; Rats; Receptors, GABA-A; Xenopus | 2010 |
Amygdalar orexinergic-GABAergic interactions regulate anxiety behaviors of the Syrian golden hamster.
Topics: Amygdala; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Cricetinae; Exploratory Behavior; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Intracellular Signaling Peptides and Proteins; Male; Mesocricetus; Neurons; Neuropeptides; Orexins; Receptors, GABA-A | 2011 |
Participation of the GABAergic system on the glutamate release of frontal cortex synaptosomes from Wistar rats with experimental autoimmune encephalomyelitis.
Topics: 4-Aminopyridine; Animals; Calcium; Encephalomyelitis, Autoimmune, Experimental; Flunitrazepam; Frontal Lobe; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Glutamic Acid; Nerve Endings; Phosphorylation; Rats; Rats, Wistar; Receptors, GABA-A; Synapsins; Synaptosomes | 2011 |
GABA-induced uncoupling of GABA/benzodiazepine site interactions is mediated by increased GABAA receptor internalization and associated with a change in subunit composition.
Topics: Animals; Benzodiazepines; Binding Sites; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Flunitrazepam; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Gene Expression Regulation; Neurons; Picrotoxin; Protein Binding; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Time Factors; Tritium | 2014 |
Effect of meta-chlorobenzhydryl urea (m-ClBHU) on benzodiazepine receptor system in rat brain during experimental alcoholism.
Topics: Alcoholism; Animals; Anticonvulsants; Benzodiazepinones; Brain; Flunitrazepam; gamma-Aminobutyric Acid; Genetic Predisposition to Disease; Hydrocarbons, Chlorinated; Male; Phenylurea Compounds; Rats; Rats, Wistar; Receptors, GABA-A; Synaptic Transmission; Tritium | 2014 |
Sedative-Hypnotic Agents That Impact Gamma-Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma-Hydroxybutyric Acid, Phenibut, and Selank.
Topics: Drug Overdose; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Hypnotics and Sedatives; Oligopeptides; Receptors, GABA; Receptors, Metabotropic Glutamate; Substance Withdrawal Syndrome; Substance-Related Disorders | 2021 |
High Fat Diet Increases [
Topics: Animals; Brain; Diet, High-Fat; Dopamine; Female; Flunitrazepam; gamma-Aminobutyric Acid; Mammals; Mice; Mice, Knockout; Neurotransmitter Agents; Receptors, Dopamine D1; Receptors, GABA-A | 2022 |