flunitrazepam has been researched along with diazepam in 381 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 221 (58.01) | 18.7374 |
| 1990's | 99 (25.98) | 18.2507 |
| 2000's | 38 (9.97) | 29.6817 |
| 2010's | 19 (4.99) | 24.3611 |
| 2020's | 4 (1.05) | 2.80 |
| Authors | Studies |
|---|---|
| Blair, T; Webb, GA | 1 |
| Barbaz, BS; Bernard, PS; Braunwalder, AF; Cash, WD; Francis, JE; Friedmann, RC; Hyun, JL; Loo, PS; Lovell, RA; Mazzenga, GC | 1 |
| Aoyama, T; Ichikawa, H; Suzuki, Y | 1 |
| Anderson, PS; Bock, MG; Chang, RS; DiPardo, RM; Evans, BE; Freidinger, RM; Lundell, GF; Rittle, KE; Veber, DF; Whitter, WL | 1 |
| Bock, MG; DiPardo, RM; Evans, BE; Freidinger, RM; Gould, NP; Homnick, CF; Lundell, GF; Rittle, KE; Veber, DF; Whitter, WL | 1 |
| Lukovits, I | 1 |
| Lopata, A; Lukovits, I | 1 |
| Johnston, GA; Maddalena, DJ | 1 |
| Karplus, M; So, SS | 1 |
| Cook, JM; Dayer, CA; He, X; Huang, Q; Liu, R; Ma, C; McKernan, R; Wenger, GR; Yu, S | 1 |
| Bromidge, FA; Collins, I; Davey, WB; McKernan, RM; Quirk, K; Rowley, M; Thompson, SA; Wafford, KA | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Chang, TK; Ensom, MH; Kiang, TK | 1 |
| Chou, WH; McMahon, T; Messing, RO; Newton, PM; Qi, ZH; Shokat, KM; Song, M; Wallace, MJ; Wang, D; Zhang, C | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Clayton, T; Cook, J; DeLorey, TM; Furtmüller, R; Halliwell, RF; Harris, D; Huck, S; Sahbaie, P; Sieghart, W | 1 |
| Anzini, M; Betti, L; Braile, C; Cappelli, A; Ghelardini, C; Giannaccini, G; Giorgi, G; Ian Fryer, R; Limongelli, V; Lucacchini, A; Makovec, F; Marinelli, L; Norcini, M; Novellino, E; Valenti, S; Vomero, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Alelyunas, YW; Bui, K; Empfield, JR; McCarthy, D; Pelosi-Kilby, L; Shen, C; Spreen, RC | 1 |
| Alcaro, S; Anzini, M; Betti, L; Biggio, G; Braile, C; Cappelli, A; Daniele, S; Di Cesare Mannelli, L; Ghelardini, C; Giannaccini, G; Giorgi, G; Limongelli, V; Lucacchini, A; Marinelli, L; Martini, C; Mascia, MP; Novellino, E; Ortuso, F; Valenti, S; Vomero, S | 1 |
| Anzini, M; Betti, L; Biggio, G; Braile, C; Cappelli, A; Castriconi, F; Di Capua, A; Di Cesare Mannelli, L; Frosini, M; Ghelardini, C; Giannaccini, G; Giorgi, G; Giuliani, G; Grisci, G; Lucacchini, A; Mascia, MP; Paolino, M; Ricci, L; Valenti, S; Vomero, S | 1 |
| Ahmed, T; Cook, JM; Golani, LK; Mondal, P; Pandey, KP; Rezvanian, S; Sharmin, D; Witkin, JM; Yeunus Mian, M | 1 |
| Clarke, RS; Dundee, JW; George, KA; Nair, SK; Vardarajan, CR | 1 |
| Andics, A; Gogolák, G; Huck, S; Stumpf, C | 1 |
| Haefely, W; Polc, P | 1 |
| Dundee, JW; George, KA | 2 |
| De Castro, J; Parmentier, P | 1 |
| Bryer, JV; Moshal, MG; Rubin, J | 1 |
| Clarke, RS; Lyons, SM | 1 |
| Giménez, JC; Parietti, A; Venturini, AH | 1 |
| Dundee, JW; Hegarty, JE | 1 |
| Averill, K; Bosmann, HB; Case, KR; DiStefano, P; Penney, DP | 1 |
| Himberg, JJ; Hytönen, M; Korttila, K; Saarnivaara, L; Tarkkanen, J | 1 |
| Dick, W; Knoche, E; Traub, E | 1 |
| Heinzl, H; Hossli, G | 1 |
| Eberlein, HJ; Hess, W; Schmidt, D; Tarnow, J | 2 |
| Schulte-Steinberg, O | 1 |
| Pasch, T; Rügheimer, E | 1 |
| Jovanović, UJ | 1 |
| Dölp, R; Heyden, M | 1 |
| Finlayson, ND; Forrest, JA; Heading, RC; Nimmo, WS; Prescott, LF | 1 |
| Klose, R; Lutz, H; Rohowsky, R; Tolksdorf, W | 1 |
| Bird, ED; Reisine, TD; Speth, RC; Wastek, GJ; Yamamura, HI | 1 |
| Frei, K | 1 |
| Dudai, Y | 1 |
| Bosmann, HB; Case, KR; Colello, GD; DiStefano, P | 1 |
| Deligné, P; Mak, D; Richard, P | 2 |
| Bugsch, LA; Pasch, T | 1 |
| Manford, ML; Richardson, FJ | 1 |
| Himberg, JJ; Lindgren, L; Saarnivaara, L | 2 |
| Kärkkäinen, T; Kokko, T; Mattila, MA; Säilä, K | 1 |
| Barnard, EA; Chang, LR; Dolly, JO; Lang, B | 1 |
| Lasserre, E | 1 |
| Dudai, Y; Yavin, E; Yavin, Z | 1 |
| Alvisi, R; Guberti, A; Pavanelli, L; Sibilla, C | 1 |
| Reisine, TD; Speth, RC; Wastek, GJ; Yamamura, HI | 1 |
| Doenicke, A; Lorenz, W | 1 |
| Korttila, K | 1 |
| Blum, AL; Brändli, H; Bron, B; Krejs, GJ; Pelloni, S; Peter, P | 1 |
| Cundrle, I; Navrátilová, A; Varmuzková, J | 1 |
| Bryer, JV; Greenberg, MJ; Moshal, MG; Rubin, J; Spitaels, JM; White, E | 1 |
| Baraldi, M; Costa, E; Guidotti, A; Schwartz, JP | 1 |
| Bresolin, N; Speth, RC; Yamamura, HI | 1 |
| Braestrup, C; Squires, RF | 1 |
| Cantanna, R; da Rin Betta, V | 1 |
| Ewers, H; Huck, S; Jindra, R; Stumpf, C | 1 |
| Bekersky, I; Brooks, MA; de Silva, JA; Puglisi, CV; Weinfeld, RE | 1 |
| Fujisawa, T; Fukushima, K; Iida, A; Kamekura, N; Kimura, Y; Kitagawa, E; Kumagai, M; Nakamura, M | 1 |
| Davies, MF; Loew, GH; Maguire, PA; Villar, HO | 1 |
| Andrews, N; File, SE; Zharkovsky, A | 1 |
| Uusi-Oukari, M | 2 |
| Hales, TG; Kim, H; Longoni, B; Olsen, RW; Tobin, AJ | 1 |
| Dodd, PR; Harper, CG; Kril, JJ; Thomas, GJ | 1 |
| Gilad, GM; Gilad, VH; Wyatt, RJ | 1 |
| Kokka, N; Olsen, RW; Sapp, DW; Witte, U | 1 |
| Brodie, MJ; Larkin, JG; Scobie, G; Thompson, GG | 1 |
| Furuie, MA; Hibino, S; Maruyama, T; Otagiri, M | 1 |
| Wilson, MA | 1 |
| Allan, AM; Baier, LD; Zhang, X | 1 |
| Bjørklund, R; Bjørneboe, A; Christophersen, AS; Dahlin, E; Ingum, J; Mørland, J | 1 |
| Gallaher, EJ; Phillips, TJ | 1 |
| Bjørklund, R; Bjørneboe, A; Ingum, J; Mørland, J | 1 |
| Augeri, C; De Grandi, R; Focacci, V; Germi, MR; Launo, C; Palermo, S; Riello, R; Riverso, P; Spirandelli, P | 1 |
| Hashimoto, Y; Iwatsuki, N; Kato, M; Koga, Y; Sato, S; Sodeyama, N; Takahashi, M | 1 |
| Allan, AM; Draski, LJ; Mayes, GG | 1 |
| Drescher, U; Kellenberger, S; Knoflach, F; Malherbe, P; Möhler, H; Rhyner, T; Sigel, E; Villa, M | 1 |
| Kaltwasser, MT | 1 |
| Oien, TT; Sethy, VH | 1 |
| Breimer, DD; de Boer, AG; van Hoogdalem, E | 1 |
| Biggio, G; Concas, A; Foddi, C; Sanna, E; Serra, M | 1 |
| Back, DJ; Eagling, VA; Macleod, R; Sim, SM | 1 |
| Ishimura, Y; Morisaki, H; Nagano, M; Sekiguchi, H; Takeda, J; Tanaka, T | 1 |
| Moro, ME; Novillo-Fertrell, J; Rodriguez, LJ; Velazquez, MM | 1 |
| Martin, WR; Sloan, JW; Wala, EP | 1 |
| Daubländer, M; Lipp, M | 1 |
| Michels, KM; Moore, RY; Morin, LP | 1 |
| De Luca, C; De Medici, D; Massotti, M | 1 |
| Doenicke, A; Greim, M; Juhl, G; Rampf, U; Suttmann, H | 1 |
| Albers, HE; Liou, SY; Shibata, S; Ueki, S | 1 |
| Bennett, DA; Braunwalder, AF; Jarvis, MF; Loo, PA; Schmutz, M; Thompson, TN; Wasley, JW; Williams, M; Yokoyoma, N | 1 |
| Wong, PT | 1 |
| Bjørklund, R; Bjørneboe, A; Christophersen, AS; Ingum, J; Mørland, J; Pettersen, G | 1 |
| Churchill, L; Cross, RS; Nelson, SR; Pazdernik, TL; Samson, FE | 1 |
| Calandra, RS; Calvo, DJ; Medina, JH; Ritta, MN | 1 |
| Keller, I; Klasing, S; Madler, C; Schwender, D | 1 |
| Betschart, J; Blanchard, JC; Piot, O; Stutzmann, JM | 1 |
| Harro, J; Lang, A; Vasar, E | 1 |
| Hole, K; Rosland, JH | 1 |
| Bares, K; Hahn, A; Navara, M; Sonka, K; Taudy, M | 1 |
| Allan, AM; Gallaher, EJ; Gionet, SE; Harris, RA | 1 |
| Chiu, TH; Rosenberg, HC; Tietz, EI | 3 |
| Kubo, H; Miura, H; Nishida, A; Nishikawa, T; Ohtani, H; Sudo, Y; Sunaoshi, W | 1 |
| Besson, MJ; Caboche, J; Le Saux, F; Maurin, Y; Mitrovic, N; Sauter, A | 1 |
| Bigl, V; Rothe, T | 1 |
| Harary, N; Kellogg, C | 1 |
| Lüddens, H; Pritchett, DB; Seeburg, PH | 1 |
| Meliksetyan, MB | 1 |
| Endo, Y; Kokubu, M; Ohtomo, F; Shinya, N | 1 |
| Caldara, A; Fogh, B; Høegholm, A; Pedersen, C; Steptoe, P | 1 |
| Morisaki, H | 1 |
| Altissimi, C; Aragona, P; Borgia, ML; Manni, MP; Patrizi, A; Pattumelli, MC; Pelagalli, L; Principi, F | 1 |
| Akaike, N; Kaneda, M; Oyama, Y; Wakamori, M | 1 |
| Cecchi, L; Colotta, V; Filacchioni, G; Galli, A; Melani, F; Palazzino, G | 1 |
| du Cailar, J; Kienlen, J | 1 |
| Cox, DH; Guidotti, A; Santi, MR | 1 |
| Maksay, G; Simonyi, M | 1 |
| Lloyd, KG; Zivkovic, B | 1 |
| Chang, YF; Chen, JS; Hargest, V | 1 |
| Brown, CL; Dodd, RH; Potier, MC; Prado de Carvalho, L; Rossier, J | 1 |
| Hawkins, M; Pravica, M; Radulovacki, M | 1 |
| Gobbi, M; Mennini, T; Perin, L; Salmona, M | 1 |
| Hawkins, M; Pan, W; Radulovacki, M; Stefanovich, P | 1 |
| Marczynski, TJ; Urbancic, M | 1 |
| Harro, J; Kiivet, RA; Pŏld, M; Rägo, L | 1 |
| Davies, N; Dodd, PR; Gundlach, AL; Harper, CG; Johnston, GA; Kril, JJ; Watson, WE | 1 |
| Hofer, P; Scollo-Lavizzari, G | 1 |
| Peroutka, SJ | 1 |
| Barone, D; Gobbi, M; Mennini, T | 1 |
| Nishikawa, T; Scatton, B | 1 |
| McGeer, E; McGeer, PL | 1 |
| Boespflug, O; Swaiman, KF | 1 |
| Barrett, JE; Mansbach, RS; Skolnick, P; Weissman, BA; Witkin, JM | 1 |
| Komiskey, HL | 1 |
| Concas, A; Morelli, M; Obata, T; Serra, M; Yamamura, HI | 1 |
| Barattini, M; Fantozzi, R; Mannaioni, PF; Masini, E | 1 |
| Bonetti, EP; Burkard, WP; Cumin, R; Haefely, WE; Martin, JR; Pieri, L; Schaffner, R | 1 |
| Gallager, DW; Marley, RJ | 1 |
| Boros, M; Falkay, G; Kertész, A | 1 |
| Fillenz, M; Fung, SC | 1 |
| Crawford, RD; Davis, LG; Fisher, TE; Johnson, DD; Tuchek, JM | 1 |
| Baraldi, PG; Borea, PA; Guarneri, M; Manfredini, S; Periotto, V; Simoni, D | 1 |
| Johnson, MR; Koe, BK; Melvin, LS; Milne, GM; Weissman, A | 1 |
| Kempner, ES; Paul, SM; Schwartz, RD; Skolnick, P; Thomas, JW | 1 |
| Bardakdjian, J; Costa, MF; Dupre, G; Fages, C; Rolland, B; Tardy, M | 1 |
| Baltzer, V; Bernasconi, R; Bittiger, H; Klebs, K; Klein, M; Schmutz, M | 1 |
| Lee, RJ; Lomax, P; McCabe, RT; Olsen, RW; Wamsley, JK | 1 |
| Abraham, CJ; De Blas, AL; Haney, SA; Park, D; Rayner, CA; Sangameswaran, L | 1 |
| Bechtel, WD; Ensinger, HA; Mierau, J | 1 |
| Sieghart, W | 1 |
| Fioretti, P; Galbani, P; Gambacciani, M; Melis, GB; Ronca-Testoni, S | 1 |
| Biziere, K; Bourguignon, JJ; Chambon, JP; Heaulme, M; Perio, A; Tebib, S; Wermuth, CG | 1 |
| Crofton, KM; Mailman, RB; Reiter, LW | 1 |
| Bjørneboe, A; Bjørneboe, GE; Bugge, A; Drevon, CA; Gjerde, H; Mørland, J | 1 |
| Poshivalov, VP; Rozhanets, VV; Sukhotina, IA | 1 |
| Badran, I; Hunjul, N; Sbeih, Z; Takrouri, MS; Toukan, A | 1 |
| Lanore, JJ; Manfredi, R; Sockeel, F; Tannières, ML; Vourc'h, G | 1 |
| Gibert-Rahola, J; Leonsegui, I; Maldonado, R; Micó, JA; Saavedra, MC | 1 |
| Amoia, M; Azzollini, CV; Donadio, S; Ippedico, M | 1 |
| Thomas, WA | 1 |
| Marano, F; Miernik, A; Santa-Maria, A | 1 |
| De Cosmo, G; Scabbia, E; Villani, A | 1 |
| Auneau, C; Blanloeil, Y; Cozian, A; Helias, J; Lepage, JY; Pinaud, M; Souron, R | 1 |
| Villiger, JW | 1 |
| Kurka, P | 1 |
| Pearce, C | 1 |
| Korttila, K; Linnoila, M | 1 |
| Barone, D; Colombo, G; Glasser, A; Luzzani, F; Mennini, T | 1 |
| Brown, C; Jones, B; Martin, I; Oakley, N | 1 |
| Bender, AS; Hertz, L | 1 |
| Beaumont, K; Fanestil, DD; Healy, DP | 1 |
| Braestrup, C; Tacke, U | 1 |
| Fioretti, P; Galbani, P; Gambacciani, M; Melis, G; Ronca-Testoni, S | 1 |
| Anderson, RA; Mitchell, R | 1 |
| Caputti, E; Cardinali, DP; Lowenstein, PR; Rosenstein, R | 1 |
| Hamon, M; Hery, F; Jobert, A; Montastruc, JL; Soubrie, P; Thiebot, MH | 1 |
| Gibbs, JM; Lim, YT; Male, CG; Male, M; Stewart, JM | 1 |
| Clarke, RS; Dundee, JW; Howard, PJ; McGowan, WA | 1 |
| Bennett, NR; Dixon, RA; Harrison, MJ; Kenyon, C; Thornton, JA | 1 |
| Hartung, HJ; Kämmerer, T; Osswald, PM; Tolksdorf, W | 1 |
| Bryne, H; Hoel, TM; Krohn, CD; Mikkelsen, H | 1 |
| Nicholson, AN; Pascoe, PA; Stone, BM | 1 |
| Robertson, HA | 2 |
| Aromaa, U; Korttila, K | 1 |
| Bernhoff, A; Ellingsen, J | 1 |
| Dudkiewicz, J; Misterek, K | 1 |
| Lauven, PM; Schüttler, J; Schwilden, H; Stoeckel, H | 1 |
| Dichter, MA; Snodgrass, SR; White, WF | 1 |
| Grimm, VE; Hershkowitz, M | 1 |
| Janicki, P; Szreniawski, Z | 1 |
| Cano, JP; Sumirtapura, YC | 1 |
| Fujita, T; Ogawa, H; Okuaki, A; Oyama, T; Takahashi, T | 1 |
| Harris, DW; Sethy, VH | 2 |
| Kapp, W | 1 |
| Kanto, JH | 1 |
| Gallager, DW | 1 |
| Brock-Utne, JG; Dimopoulos, GE; Downing, JW; Moshal, MG; Rubin, J | 1 |
| Gee, KW; Morelli, M; Yamamura, HI | 1 |
| Aronson, HB; Haskel, Y; Vatashsky, E | 1 |
| Dohi, S; Matsumiya, N; Nishikawa, T; Takahashi, T | 1 |
| Kuhar, MJ; Niehoff, DL; Palacios, JM; Unnerstall, JR | 1 |
| Saano, V; Urtti, A | 1 |
| Chiu, TH; Rosenberg, HC | 1 |
| Garattini, S; Mennini, T | 2 |
| Aronson, HB; Vatashsky, E | 1 |
| Aronson, HB; Haskel, J; Larnau, O; Nissan, S; Vatashsky, E | 1 |
| Georgiev, VP; Getova, D; Petkov, V; Petkov, VV | 1 |
| Nicholson, AN | 1 |
| Aronson, HB; Vatashsky, E; Zaroura, S | 1 |
| Janicki, P; Libich, J; Szreniawski, Z | 1 |
| Daenzer, CL; Russell, RR; Sethy, VH | 1 |
| Barbi, S; Beccia, F; Ferraro, M; Pala, F; Sabato, AF | 1 |
| Belghiti, J; Boivin, P; Gautero, H; Goldfarb, G | 1 |
| Bernard, P; Cassidy, JP; Czernik, AJ; Petrack, B; Yokoyama, N | 1 |
| Fasching, I; Haubenstock, A; Hruby, K; Jäger, U | 1 |
| Olive, G; Rey, E | 1 |
| Keane, PE; Morre, M; Simiand, J | 1 |
| Jones, BJ; Oakley, NR; Straughan, DW | 1 |
| Ott, H | 1 |
| Garattini, S; Gobbi, M; Mennini, T | 1 |
| Braestrup, C; Nielsen, M; Olsen, CE | 1 |
| Battersby, MK; Cumin, R; Kettler, R; Möhler, H; Pieri, L; Polc, P; Richards, JG | 1 |
| Braestrup, C; Nielsen, M; Schou, H | 1 |
| Factor, MI; Korneyev, AY | 1 |
| Costa, MF; Fages, C; Gonnard, P; Rolland, B; Tardy, M | 1 |
| Tallman, JF; Thomas, JW | 1 |
| Burkard, WP; Haefely, W; Keller, HH; Möhler, H; Richards, JG | 1 |
| Dudai, Y; Sherman-Gold, R | 1 |
| Cain, M; Paul, SM; Rice, KC; Skolnick, P; Williams, EF | 1 |
| Fehske, KJ; Muller, WE | 1 |
| Biagioni, TM; Volicer, L | 1 |
| Mählmann, H; Quast, U; Vollmer, KO | 1 |
| Braestrup, C; Kehr, W; Nielsen, M; Paschelke, G; Petersen, EN | 1 |
| Gardner, CR; Piper, DC | 1 |
| Loonen, AJ; Soe-Agnie, CJ; Soudijn, W | 1 |
| Horton, RW; Prestwich, SA; Stapleton, SR | 1 |
| Brown, CL; Martin, IL | 2 |
| Brinton, RE; Gee, KW; Yamamura, HI | 1 |
| Sher, PK | 1 |
| Burch, TP; Thyagarajan, R; Ticku, MK | 1 |
| Barry, DI; Braestrup, C; Hemmingsen, R; Nielsen, M | 1 |
| Dasheiff, RM; Fanelli, RJ; Kraus, VM; McNamara, JO | 1 |
| Neale, JH; Prezioso, PJ | 1 |
| Bolger, GT; Isaac, L; Paul, SM; Skolnick, P; Weissman, BA | 1 |
| Squires, RF | 1 |
| Blanchard, JC; Boireau, A; Julou, L | 2 |
| Kato, R; Muraki, T; Yamazoe, Y | 1 |
| De Robertis, E; Medina, JH; Novas, ML | 1 |
| DeLorenzo, RJ; Taft, WC | 1 |
| Keys, C; Loew, G; Spangler, D; Toll, L | 1 |
| Decobert, M; Depoortere, H; Honoré, L | 1 |
| Berlin, J; Petrakis, N; Rey, ER; Schmidt, R; Tolksdorf, W | 1 |
| Diulcin, N; Garbarini, T; Parraguette, J; Renum, B; Sicre, B | 1 |
| Davies, MA; Dompert, WU; Glaser, T; Schuurman, T; Seidel, PR; Traber, J | 1 |
| Lindner, H; Sold, M; Weis, KH | 1 |
| Haddox, VG; Menon, MK; Vivonia, CA | 1 |
| Hess, W; Schulte-Sasse, U; Tarnow, J | 1 |
| Günther, W | 1 |
| Duka, T; Herz, A; Wüster, M | 1 |
| Ladewig, D | 1 |
| Jenck, F; Martin, JR; Moreau, JL | 2 |
| Jing, X; Sloan, JW; Wala, EP | 2 |
| Dodd, PR | 2 |
| Adachi, M; Akatsu, M; Okuaki, A; Sinoda, M; Tase, C; Terashima, M; Watanabe, K | 1 |
| Estève, C; Hamza, J; Saint-Maurice, C | 1 |
| Cazin, L; Louiset, E; Vaudry, H | 1 |
| Bjørklund, R; Ingum, J; Mørland, J; Volden, R | 1 |
| Inglefield, JR; Kellogg, CK; Sieghart, W | 1 |
| Kapetanovic, IM; Kupferberg, HJ; Torchin, CD | 1 |
| Imaizumi, M; Machida, H; Miyazaki, S; Watanabe, Y | 1 |
| Cancedda, E; Corda, MG; Giorgi, O; Lecca, D; Orlandi, M | 1 |
| Kashimoto, S; Kumazawa, T; Nakamura, T; Nonaka, A | 1 |
| Ingum, J; Mørland, J; Pettersen, G; Sager, G | 1 |
| Andes, C; Delb, W; Koch, A; Merl, E | 1 |
| Chiu, TH; Ramsey-Williams, V; Rosenberg, HC; Wu, Y | 1 |
| Nielsen, M; Witt, MR | 1 |
| Alenfall, J; Batra, S | 1 |
| Biggio, G; Concas, A; Dazzi, L; Maciocco, E; Mascia, MP; Ongini, E; Santoro, G | 1 |
| Klasing, S; Madler, C; Peter, K; Pöppel, E; Schwender, D | 1 |
| Liljequist, S; Tabakoff, B | 1 |
| Hashimoto, K; Kashimoto, S; Kumazawa, T; Oguchi, T; Yamaguchi, T | 1 |
| Brett, RR; Pratt, JA | 1 |
| Biggio, G; Ghiani, CA; Maciocco, E; Sanna, E; Serra, M; Tuligi, G | 1 |
| File, SE; Hogg, S; Mills, AD | 1 |
| Arce, A; Perillo, MA | 1 |
| Atsmon, J; Dagan, Y; Gavish, M; Laschiner, S; Laudon, M; Oaknin, S; Zisapel, N | 1 |
| Crane, DI; Dodd, PR; McCloskey, A; Smith, ID; Thomas, GJ | 1 |
| Luurila, H; Neuvonen, PJ; Olkkola, KT | 1 |
| Hatta, S; Saito, T; Takahata, N; Toki, S | 1 |
| Dodd, PR; Harper, CG; Johnston, GA; Kril, JJ; Thomas, GJ; Watson, WE | 1 |
| Fukushima, K; Morisaki, H; Takeda, J | 1 |
| Belachew, S; Coucke, P; Goffin, F; Lefebvre, PP; Malgrange, B; Moonen, G; Rigo, JM; Van de Water, TR; Xhauflaire, G | 1 |
| Bessler, H; Caspi, B; Gavish, M; Rehavi, M; Weizman, A | 1 |
| Beuck, M; Kerkhoff, C; Knudsen, J; Schmitz, G; Spener, F; Threige-Rasmussen, J | 1 |
| Andersson, G; Enerbäck, C; Engel, JA; Söderpalm, B | 1 |
| Karle, J; Nielsen, M; Witt, MR | 1 |
| Ascoli, G; Bertucci, C; Rossi, E; Salvadori, P; Uccello-Barretta, G | 1 |
| Granja, R; Gunnersen, D; Skolnick, P; Valeyev, A; Wong, G | 1 |
| Bristow, DR; Johnston, JD | 1 |
| Fukuda, K; Ichinohe, T; Kaneko, Y; Kasahara, M; Mamiya, H; Noma, T | 1 |
| Hemmersbach, P; Ragnar Norli, H; Rasmussen, KE; Reubsaet, KJ | 1 |
| Acquas, C; Biggio, G; Floris, C; Fontana, SN; Maciocco, E; Maira, G; Massa, F; Pau, D; Sanna, E; Tuveri, F | 1 |
| Alkana, RL; Bolger, MB; Brinton, RD; Davies, DL; Finn, DA | 1 |
| Bateson, AN; Holt, RA; Martin, IL | 1 |
| Chistina Grobin, A; Devaud, LL; Inglefield, JR; Morrow, AL; Schwartz-Bloom, RD | 1 |
| Chaki, S; Nagamine, M; Nakazato, A; Ogawa, S; Okubo, T; Okuyama, S; Suzuki, Y; Tomisawa, K; Yoshikawa, R | 1 |
| Bechgaard, E; Gizurarson, S; Greenough, RJ; Hjortkjaer, RK; McDonald, P; Suzdak, C | 1 |
| Bakonyi, A; Fekete, MI; Horváth, EJ; Palkovits, M; Salamon, C | 1 |
| Bono, F; Herbert, JM; Lamarche, I; Le Fur, G; Prabonnaud, V | 1 |
| Bianchin, M; Calvo, DJ; Goutman, JD; Izquierdo, I; Marder, M; Medina, JH; Paladini, AC; Viola, H; Wasowski, C; Wolfman, C | 1 |
| Li, M; Rosenberg, HC; Szabo, A | 2 |
| Blanch, LB; Estiú, G; Marder, M; Medina, JH; Paladini, AC; Viola, H; Wasowski, C | 1 |
| Betti, L; Bistocchi, M; Giannaccini, G; Gori, M; Lucacchini, A | 1 |
| Chuang, VT; Otagiri, M | 1 |
| Baufreton, J; Bioulac, B; Dovero, S; Dufy, B; Garret, M; Taupignon, A | 1 |
| Safo, P; Thompson, SA; Wafford, KA; Wheat, L; Whiting, PJ; Wingrove, PB | 1 |
| Aizawa, K; Kanai, T; Kawano, Y; Miyazawa, N; Saikawa, Y; Takabayashi, T; Yamamoto, T | 1 |
| Hodge, CW; Homanics, GE; Khisti, RT; Kralic, JE; Morrow, AL; O'Buckley, TK | 1 |
| Berkovic, SF; Bowser, DN; Cromer, BA; Czajkowski, C; Harkin, LA; Jones, MV; Marini, C; Mulley, JC; Parker, MW; Petrou, S; Wagner, DA; Wallace, RH; Williams, DA | 1 |
| Andersen, DL; Burke, CJ; Dodd, PR; Eckert, AL; Tannenberg, AE; Tsai, VW | 1 |
| Bakavoli, M; Kaykhaii, M | 1 |
| Frerichs, A; Hellige, G; Kettler, D; Klockgether-Radke, AP; Thudium, A | 1 |
| Abramov, U; Bourin, M; Kõks, S; Matsui, T; Nelovkov, A; Raud, S; Reimets, A; Rünkorg, K; Vasar, E; Veraksits, A; Volke, V | 1 |
| Druid, H; Kronstrand, R; Nyström, I; Strandberg, J | 1 |
| Jembrek, MJ; Lazić, J; Pericić, D; Rajcan, I; Strac, DS | 1 |
| Fernández, SP; Marder, M; Paladini, AC; Wasowski, C | 1 |
| Bernöster, K; Dost, R; Egerland, U; Langen, B; Rundfeldt, C; Unverferth, K | 1 |
| Bandyopadhyay, S; Beer, B; Czobor, P; Farb, DH; Gibbs, TT; Gravielle, M; Kostakis, E; Lippa, A; Russek, SJ; Skolnick, P; Stark, J | 1 |
| Asproni, B; Biggio, G; Busonero, F; Cerri, R; Maciocco, E; Mascia, MP; Pau, A; Sanna, E; Talani, G | 1 |
| Fleischhacker, WW; Golser, K; Haidekker, A; Kemmler, G; Kurzthaler, I; Pavlic, M; Sperner, G; Sperner-Unterweger, B; Wambacher, M | 1 |
| Karolewicz, B; Nail, E; Ordway, GA; Stockmeier, CA; Szebeni, K; Zhu, H | 1 |
| Lopes, DV; Mendonça-Silva, DL; Noël, F; Thibaut, JP | 1 |
| Jembrek, MJ; Pericić, D; Strac, DS; Vlainić, J | 2 |
| Galetin, A; Hallifax, D; Houston, JB | 1 |
| Jazvinsćak Jembrek, M; Pericić, D; Svob Strac, D; Vlainić, J | 1 |
| Bostwick, R; Chen, T; Huston, J; Knappenberger, K; Liu, J; Norris, T; Wood, M | 1 |
| Douglas, SA; Furukawa, K; Hashiba, E; Hirota, K; Kawaguchi, Y; Kudo, M; Kudo, T; Kushikata, T; Ono, T; Yoshida, H | 1 |
| Dervaux, A; Kanit, M; Laqueille, X; Launay, C | 1 |
| Ben-Attia, M; Ben-Cherif, W; Boughattas, NA; Dridi, D; Gharbi, R; Sebai, H | 1 |
| Dunn, SM; Kozuska, JL; Paulsen, IM; You, H | 1 |
| Frauger, E; Lapeyre-Mestre, M; Micallef, J; Natali, F; Nordmann, S; Pauly, V; Pourcel, L; Pradel, V; Sciortino, V; Thirion, X | 1 |
| Contó, MB; de Carvalho, JG; Hipólide, DC; Venditti, MA | 1 |
| Endo, K; Kakuta, Y; Kinouchi, Y; Shiga, H; Shimosegawa, T; Takahashi, S | 1 |
| Fidecka, S; Listos, J; Orzelska, J; Talarek, S | 2 |
| Andreatini, R; Baretta, IP; Chioca, LR; Ferreira, J; Ferro, MM; Losso, EM; Oliveira, SM; Silva, CR | 1 |
| Fuzii, A; Higami, T; Inaoka, M; Miyaki, Y; Nakashima, S; Uehara, M | 1 |
| Bell, SC; Martindale, SM; Powers, RH | 1 |
| Ciogli, A; Gasparrini, F; Pierini, M; Sabia, R; Villani, C | 1 |
| Cui, YL; He, X; Liu, J; Shan, WC; Wang, JP; Zhang, L | 1 |
| Cappiello, A; Famiglini, G; Palma, P; Termopoli, V | 1 |
| Fidecka, S; Kedzierska, E; Listos, J; Orzelska-Gorka, J; Talarek, S | 1 |
| Bernat, P; Fidecka, S; Kędzierska, E; Listos, J; Orzelska-Górka, J; Talarek, S; Tutka, P | 1 |
| Ishikawa, A; Kakehashi, H; Kamata, T; Katagi, M; Nakano-Fujii, S; Nitta, A; Sasaki, K; Sato, T; Shima, N; Wada, M | 1 |
| Cervantes-Anaya, N; Estrada-Camarena, E; González Trujano, ME; Islas-Preciado, D; López-Rubalcava, C; Sollozo-Dupont, I; Ugalde-Fuentes, G | 1 |
12 review(s) available for flunitrazepam and diazepam
| Article | Year |
|---|---|
Neural networks applied to quantitative structure-activity relationship analysis.
Topics: Animals; Azirines; Benzodiazepines; Carbazilquinone; Nerve Net; Nervous System; Regression Analysis; Structure-Activity Relationship | 1990 |
UDP-glucuronosyltransferases and clinical drug-drug interactions.
Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic | 2005 |
Pharmacokinetics of rectal drug administration, Part I. General considerations and clinical applications of centrally acting drugs.
Topics: Administration, Rectal; Antiemetics; Atropine; Carbamazepine; Clonazepam; Delayed-Action Preparations; Diazepam; Flunitrazepam; Humans; Hydromorphone; Intestinal Absorption; Methadone; Methohexital; Midazolam; Morphine; Pharmacokinetics; Phenobarbital; Valproic Acid | 1991 |
[Pharmacology of midazolam].
Topics: Anesthesia, General; Brain; Diazepam; Drug Interactions; Flunitrazepam; Hemodynamics; Humans; Midazolam; Preanesthetic Medication; Receptors, GABA-A; Respiration | 1987 |
The benzodiazepine receptor: the pharmacology of emotion.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Carbolines; Central Nervous System; Cerebral Cortex; Diazepam; Flunitrazepam; Humans; Ligands; Male; Mice; Neuroglia; Rats; Rats, Inbred Strains; Receptors, Drug; Receptors, GABA-A; Synaptosomes | 1980 |
[Current intravenous anesthetics].
Topics: Anesthesia, Intravenous; Anesthetics; Anti-Anxiety Agents; Benzodiazepines; Diazepam; Etomidate; Flunitrazepam; Imidazoles; Injections, Intravenous; Lorazepam; Medazepam; Midazolam; Nordazepam | 1980 |
Use of benzodiazepines during pregnancy, labour and lactation, with particular reference to pharmacokinetic considerations.
Topics: Anti-Anxiety Agents; Chlordiazepoxide; Clorazepate Dipotassium; Diazepam; Female; Flunitrazepam; Humans; Infant, Newborn; Labor, Obstetric; Lactation; Lorazepam; Maternal-Fetal Exchange; Nitrazepam; Oxazepam; Pregnancy | 1982 |
Benzodiazepine receptors': correlation with pharmacological responses in living animals.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Brain; Conflict, Psychological; Diazepam; Dose-Response Relationship, Drug; Drug Tolerance; Flunitrazepam; Kinetics; Muscle Relaxation; Pentylenetetrazole; Receptors, Cell Surface; Receptors, GABA-A | 1982 |
[Benzodiazepines and pregnancy. Transplacental passage, labor and lactation].
Topics: Anti-Anxiety Agents; Biotransformation; Chlordiazepoxide; Clorazepate Dipotassium; Diazepam; Female; Flunitrazepam; Humans; Kinetics; Lorazepam; Maternal-Fetal Exchange; Milk, Human; Nitrazepam; Oxazepam; Postpartum Period; Pregnancy | 1983 |
Benzodiazepine receptor multiplicity.
Topics: Animals; Brain; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Pyridazines; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Drug effects on the EEG of various species of laboratory animals.
Topics: 5-Hydroxytryptophan; Amantadine; Animals; Antihypertensive Agents; Azabicyclo Compounds; Brain; Cats; Chlormethiazole; Clonidine; Diazepam; Electroencephalography; Flunitrazepam; Guanabenz; Guanfacine; Guanidines; Imidazoles; Male; Nitrazepam; Pentobarbital; Phenylacetates; Piperazines; Piracetam; Rats; Sodium Oxybate; Yohimbine | 1983 |
[Abuse of alcohol and benzodiazepine during substitution therapy in heroin addicts: a review of the literature].
Topics: Adolescent; Adult; Alcoholism; Benzodiazepines; Buprenorphine; Clonazepam; Clorazepate Dipotassium; Comorbidity; Controlled Clinical Trials as Topic; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Ethanol; Euphoria; Flunitrazepam; Heroin Dependence; Humans; Metabolic Clearance Rate; Methadone; Narcotics; Substance-Related Disorders; Young Adult | 2009 |
48 trial(s) available for flunitrazepam and diazepam
| Article | Year |
|---|---|
Relative amnesic actions of diazepam, flunitrazepam and lorazepam in man.
Topics: Amnesia; Anesthesia; Anti-Anxiety Agents; Diazepam; Female; Flunitrazepam; Humans; Lorazepam; Time Factors | 1977 |
Premedication with flunitrazepam in gastro-intestinal endoscopy.
Topics: Anti-Anxiety Agents; Diazepam; Duodenum; Endoscopy; Flunitrazepam; Gastroscopy; Humans; Premedication; Propantheline | 1977 |
Diazepam and flunitrazepam as induction agents for cardiac surgical operations.
Topics: Anti-Anxiety Agents; Blood Pressure; Carbon Dioxide; Cardiac Surgical Procedures; Diazepam; Double-Blind Method; Drug Evaluation; Flunitrazepam; Heart Rate; Humans; Oxygen; Partial Pressure; Preanesthetic Medication; Time Factors | 1977 |
[Flunitrazepam (Ro 5-4200): a new benzodiazepinic derivative. Comparative double blind study with diazepam to control the psychomotor reactions of ketamine].
Topics: Adolescent; Adult; Aged; Akathisia, Drug-Induced; Anti-Anxiety Agents; Diazepam; Dilatation and Curettage; Double-Blind Method; Drug Evaluation; Female; Flunitrazepam; Humans; Ketamine; Middle Aged; Psychomotor Agitation | 1977 |
Sequelae after the intravenous injection of three benzodiazepines--diazepam, lorazepam, and flunitrazepam.
Topics: Anti-Anxiety Agents; Diazepam; Flunitrazepam; Humans; Injections, Intravenous; Lorazepam; Phlebitis; Thrombophlebitis | 1977 |
Comparison of diazepam and flunitrazepam for sedation during local anaesthesia for bronchoscopy.
Topics: Adult; Aged; Amnesia; Anesthesia, Local; Anti-Anxiety Agents; Bronchoscopy; Cardiovascular System; Diazepam; Flunitrazepam; Humans; Middle Aged; Surveys and Questionnaires; Time Factors | 1978 |
[Effects of diazepam and flunitrazepam on the undesired postoperative side-effects of ketamine anaesthesia (author's transl)].
Topics: Adult; Anti-Anxiety Agents; Anxiety; Atropine; Diazepam; Double-Blind Method; Female; Flunitrazepam; Humans; Ketamine; Middle Aged; Placebos; Premedication | 1978 |
[The administration and dosage of flunitrazepam as premedication. II].
Topics: Anti-Anxiety Agents; Clinical Trials as Topic; Diazepam; Double-Blind Method; Female; Flunitrazepam; Humans; Hypnotics and Sedatives; Male; Preanesthetic Medication; Sleep | 1978 |
[Vigilance pattern and sleep quality under the effect of flunitrazepam].
Topics: Adult; Anti-Anxiety Agents; Attention; Clinical Trials as Topic; Diazepam; Electroencephalography; Female; Flunitrazepam; Humans; Male; Phenobarbital; Placebos; Sleep; Sleep Wake Disorders | 1978 |
[The administration and dosage of flunitrazepam as premedication. I].
Topics: Adult; Anti-Anxiety Agents; Blood Gas Analysis; Clinical Trials as Topic; Diazepam; Female; Flunitrazepam; Hemodynamics; Humans; Male; Middle Aged; Preanesthetic Medication; Sleep; Time Factors | 1978 |
[The influence of sedation with diazepam and flunitrazepam during regional anaesthesia upon postoperative pulmonary performance (author's transl)].
Topics: Anesthesia, Conduction; Anti-Anxiety Agents; Diazepam; Flunitrazepam; Forced Expiratory Volume; Humans; Lung; Male; Peak Expiratory Flow Rate; Prostatectomy; Vital Capacity | 1979 |
[Comparative study on the sedation of geriatric patients during spinal anesthesia].
Topics: Age Factors; Aged; Anesthesia, Spinal; Anti-Anxiety Agents; Blood Pressure; Bupivacaine; Carbon Dioxide; Clinical Trials as Topic; Diazepam; Female; Flunitrazepam; Humans; Hydrogen-Ion Concentration; Male; Oxygen; Partial Pressure; Respiration | 1979 |
Comparison of flunitrazepam and diazepam for oral premedication in older children.
Topics: Anti-Anxiety Agents; Child; Clinical Trials as Topic; Diazepam; Double-Blind Method; Flunitrazepam; Humans; Mental Recall; Preanesthetic Medication; Random Allocation; Time Factors | 1979 |
Comparison of I.M. pethidine, diazepam and flunitrazepam as premedicants in children undergoing otolaryngological surgery.
Topics: Adolescent; Age Factors; Anti-Anxiety Agents; Anxiety; Child; Child, Preschool; Clinical Trials as Topic; Diazepam; Double-Blind Method; Female; Flunitrazepam; Humans; Infant; Injections, Intramuscular; Male; Mental Recall; Meperidine; Otorhinolaryngologic Diseases; Preanesthetic Medication; Random Allocation; Time Factors | 1979 |
Comparison of diazepam and flunitrazepam as adjuncts to general anaesthesia in preventing arousal following surgical stimuli.
Topics: Abdomen; Adjuvants, Anesthesia; Adult; Anesthesia, General; Anesthesia, Intravenous; Anti-Anxiety Agents; Arousal; Clinical Trials as Topic; Diazepam; Female; Flunitrazepam; Humans; Physical Stimulation; Random Allocation; Surveys and Questionnaires | 1979 |
The effect of diazepam, flunitrazepam and droperidol with an analgesic on blood pressure and heart rate in man.
Topics: Adult; Anti-Anxiety Agents; Blood Pressure; Clinical Trials as Topic; Depression, Chemical; Diazepam; Dose-Response Relationship, Drug; Droperidol; Drug Interactions; Female; Fentanyl; Flunitrazepam; Heart Rate; Humans; Injections, Intravenous; Male; Meperidine; Time Factors | 1975 |
[Controlled trials of premedication of fiberendoscopy (author's transl)].
Topics: Adult; Aged; Anesthesia, Local; Clinical Trials as Topic; Diazepam; Endoscopy; Fiber Optic Technology; Flunitrazepam; Humans; Middle Aged; Placebos; Premedication | 1978 |
Relationship between drug plasma concentrations and psychomotor performance after single doses of ethanol and benzodiazepines.
Topics: Adult; Analysis of Variance; Diazepam; Double-Blind Method; Ethanol; Flunitrazepam; Humans; Male; Psychomotor Performance; Reaction Time; Sleep | 1992 |
[Clinical evaluation of pre-surgical anxiety: changes in plasma levels of the anxiety peptide (diazepam binding inhibitor)].
Topics: Adult; Aged; Anxiety; Diazepam; Diazepam Binding Inhibitor; Female; Flunitrazepam; Humans; Male; Middle Aged; Neuropeptides; Preanesthetic Medication; Preoperative Care; Promethazine; Surgical Procedures, Operative | 1992 |
[Beta activation following the intravenous administration of benzodiazepines and the specific antagonist flumazenil (Ro 15-1788)].
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Beta Rhythm; Diazepam; Dose-Response Relationship, Drug; Electroencephalography; Flumazenil; Flunitrazepam; Humans; Injections, Intravenous; Lorazepam; Male; Midazolam; Prospective Studies; Randomized Controlled Trials as Topic; Stimulation, Chemical | 1990 |
[Mid-latency auditory evoked potentials during induction of intravenous anesthesia using midazolam, diazepam and flunitrazepam].
Topics: Adult; Anesthesia, Intravenous; Diazepam; Evoked Potentials, Auditory; Female; Flunitrazepam; Genitalia, Female; Humans; Midazolam; Middle Aged; Minor Surgical Procedures; Reaction Time | 1990 |
Benzodiazepine antagonism by aminophylline.
Topics: Adult; Aged; Aged, 80 and over; Aminophylline; Anti-Anxiety Agents; Clinical Trials as Topic; Diazepam; Double-Blind Method; Female; Flunitrazepam; Humans; Male; Middle Aged; Preanesthetic Medication; Random Allocation | 1989 |
[Comparison of the use of classic diazoanalgesia in surgery and an applicative variant with buprenorphine].
Topics: Adult; Aged; Blood Pressure; Buprenorphine; Clinical Trials as Topic; Diazepam; Female; Fentanyl; Flunitrazepam; Gynecology; Humans; Middle Aged; Pain, Postoperative; Preanesthetic Medication; Random Allocation | 1989 |
Diazepam, flunitrazepam and midazolam for elective endoscopy--a comparative study.
Topics: Adult; Anxiety; Clinical Trials as Topic; Diazepam; Female; Flunitrazepam; Gastroscopy; Humans; Infusions, Intravenous; Male; Memory; Midazolam; Random Allocation | 1988 |
[Clinical evaluation of flumazenil (Anexate) on the recovery parameters following the administration of 3 benzodiazepines (flunitrazepam, midazolam or diazepam].
Topics: Adult; Aged; Analgesics; Anesthesia Recovery Period; Anesthesia, General; Benzodiazepines; Diazepam; Drug Evaluation; Female; Flumazenil; Flunitrazepam; Humans; Male; Midazolam; Middle Aged; Postoperative Period; Prospective Studies; Random Allocation; Respiration | 1987 |
A clinical trial of Ro5-4200 (flunitrazepam) used to supplement spinal anaesthesia in elderly patients.
Topics: Abdomen; Aged; Anesthesia, Spinal; Blood Pressure; Carbon Dioxide; Clinical Trials as Topic; Diazepam; Flunitrazepam; Humans; Male; Partial Pressure; Preanesthetic Medication; Tablets; Time Factors | 1974 |
Skills related to driving after intravenous diazepam, flunitrazepam or droperidol.
Topics: Anesthesia Recovery Period; Anesthesia, Intravenous; Attention; Automobile Driving; Diazepam; Dose-Response Relationship, Drug; Double-Blind Method; Droperidol; Female; Flicker Fusion; Flunitrazepam; Humans; Male; Psychomotor Performance; Randomized Controlled Trials as Topic; Reaction Time; Time Factors | 1974 |
Comparison of oral triclofos, diazepam and flunitrazepam as premedicants in children undergoing otolaryngological surgery.
Topics: Administration, Oral; Adolescent; Anti-Anxiety Agents; Anxiety; Atropine; Child; Child, Preschool; Clinical Trials as Topic; Diazepam; Double-Blind Method; Ethylene Chlorohydrin; Female; Flunitrazepam; Heart Rate; Humans; Hypnotics and Sedatives; Male; Organophosphates; Organophosphorus Compounds; Otorhinolaryngologic Diseases; Preanesthetic Medication; Salivation | 1980 |
Comparison of three benzodiazepines for oral premedication in minor gynaecological surgery.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Anxiety; Clinical Trials as Topic; Diazepam; Dilatation and Curettage; Double-Blind Method; Female; Flunitrazepam; Humans; Lorazepam; Mental Recall; Middle Aged; Personality Inventory; Placebos; Preanesthetic Medication; Random Allocation | 1980 |
Comparison of the subjective effects and plasma concentrations following oral and i.m. administration of flunitrazepam in patients.
Topics: Administration, Oral; Adult; Anti-Anxiety Agents; Clinical Trials as Topic; Diazepam; Double-Blind Method; Female; Flunitrazepam; Humans; Injections, Intramuscular; Lorazepam; Pain; Preanesthetic Medication; Random Allocation; Time Factors | 1980 |
I.v. flunitrazepam and i.v. diazepam in conservative dentistry. A cross-over trial.
Topics: Adolescent; Adult; Anesthesia, Dental; Anesthesia, Local; Anti-Anxiety Agents; Clinical Trials as Topic; Diazepam; Flunitrazepam; Hemodynamics; Humans; Injections, Intravenous; Middle Aged; Preanesthetic Medication; Random Allocation; Research Design | 1980 |
[Experiences with continuous application of sedatives by infusion in patients with regional anaesthesia (author's transl)].
Topics: Adolescent; Adult; Anesthesia, Conduction; Anthracenes; Anti-Anxiety Agents; Carbon Dioxide; Diazepam; Flunitrazepam; Humans; Infusions, Parenteral; Middle Aged; Oxygen; Respiratory Function Tests | 1980 |
Local reactions after i.v. injections of diazepam, flunitrazepam and isotonic saline.
Topics: Adult; Aged; Anti-Anxiety Agents; Diazepam; Flunitrazepam; Humans; Injections, Intravenous; Isotonic Solutions; Middle Aged; Preanesthetic Medication; Sodium Chloride; Thrombophlebitis | 1980 |
Efficacy of some benzodiazepines for day-time sleep.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Diazepam; Electroencephalography; Female; Flunitrazepam; Humans; Male; Ovum; Placebos; Sleep; Time Factors; Triazolam | 1980 |
[Flunitrazepam -- an alternative to diazepam in neuroleptanalgesia].
Topics: Adult; Anti-Anxiety Agents; Clinical Trials as Topic; Diazepam; Double-Blind Method; Female; Flunitrazepam; Humans; Male; Middle Aged; Random Allocation | 1980 |
[Joint clinical evaluation of flunitrazepam on the multicenter basis -- comparative studies with diazepam (author's transl)].
Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Child; Clinical Trials as Topic; Diazepam; Female; Flunitrazepam; Humans; Male; Middle Aged; Preanesthetic Medication | 1981 |
Are electroencephalographic and psychomotor measures sensitive in detecting residual sequelae of benzodiazepine hypnotics?
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Diazepam; Double-Blind Method; Electroencephalography; Female; Flunitrazepam; Half-Life; Humans; Hypnotics and Sedatives; Lorazepam; Male; Middle Aged; Psychomotor Performance; Radioligand Assay; Sleep | 1984 |
[Stress reduction by i.m. premedication with 6 different single substances].
Topics: Adolescent; Adult; Aged; Anesthesia, Conduction; Anesthesia, General; Buprenorphine; Cardiovascular System; Clinical Trials as Topic; Diazepam; Droperidol; Female; Flunitrazepam; Humans; Injections, Intramuscular; Male; Meperidine; Middle Aged; Preanesthetic Medication; Stress, Psychological; Triflupromazine | 1984 |
[Effect of fentanyl, diazepam and flunitrazepam on memory function. A pharmacopsychologic study].
Topics: Diazepam; Fentanyl; Flunitrazepam; Humans; Memory; Memory, Short-Term; Reaction Time | 1983 |
[Hemodynamic analysis of 6 different anesthesia induction procedures in coronary surgery patients].
Topics: Alfaxalone Alfadolone Mixture; Anesthesia, Intravenous; Coronary Artery Bypass; Coronary Disease; Diazepam; Etomidate; Fentanyl; Flunitrazepam; Hemodynamics; Humans; Ketamine; Myocardium; Oxygen Consumption; Preanesthetic Medication; Thiopental | 1982 |
[The effect of flumazenil in reversing midazolam, flunitrazepam or diazepam].
Topics: Adolescent; Adult; Anesthesia Recovery Period; Anesthesia, Epidural; Anesthesia, Spinal; Diazepam; Female; Flumazenil; Flunitrazepam; Hemodynamics; Humans; Male; Midazolam; Middle Aged; Respiration | 1995 |
Development of acute tolerance after oral doses of diazepam and flunitrazepam.
Topics: Adult; Attention; Circadian Rhythm; Diazepam; Double-Blind Method; Drug Tolerance; Flunitrazepam; Humans; Male; Psychomotor Performance; Reaction Time | 1994 |
Relationship between unbound plasma concentrations and various psychomotor and subjective effects after intakes of diazepam and flunitrazepam.
Topics: Adult; Blood Proteins; Diazepam; Dose-Response Relationship, Drug; Flunitrazepam; Humans; Male; Psychomotor Performance; Reaction Time | 1994 |
Effects of benzodiazepines on mid-latency auditory evoked potentials.
Topics: Acoustic Stimulation; Adult; Anesthesia, Intravenous; Auditory Cortex; Awareness; Diazepam; Evoked Potentials, Auditory; Evoked Potentials, Auditory, Brain Stem; Female; Flunitrazepam; Humans; Midazolam; Middle Aged; Reaction Time; Reflex, Acoustic | 1993 |
Interaction between erythromycin and the benzodiazepines diazepam and flunitrazepam.
Topics: Adult; Animals; Antioxidants; Aspartate Aminotransferases; Bepridil; Biphenyl Compounds; Cross-Over Studies; Diazepam; Double-Blind Method; Drug Interactions; Erythromycin; Female; Flunitrazepam; Free Radicals; Humans; L-Lactate Dehydrogenase; Lipid Peroxidation; Lipoxygenase Inhibitors; Liver; Male; Picrates; Rats; Rats, Wistar | 1996 |
Pain following intravenous administration of sedative agents: a comparison of propofol with three benzodiazepines.
Topics: Adult; Analysis of Variance; Anesthetics, Intravenous; Anesthetics, Local; Anti-Anxiety Agents; Cross-Over Studies; Diazepam; Double-Blind Method; Drug Combinations; Female; Flunitrazepam; Humans; Injections, Intravenous; Lidocaine; Male; Midazolam; Pain; Pain Measurement; Propofol; Prospective Studies | 1998 |
A novel approach to the prevention of postoperative delirium in the elderly after gastrointestinal surgery.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Anti-Anxiety Agents; Delirium; Diazepam; Digestive System Surgical Procedures; Drug Therapy, Combination; Female; Flunitrazepam; Gastrointestinal Neoplasms; Humans; Infusions, Intravenous; Injections, Intramuscular; Male; Meperidine; Postoperative Complications; Premedication; Prospective Studies | 2002 |
Selective anxiolysis produced by ocinaplon, a GABA(A) receptor modulator.
Topics: Adult; Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety Disorders; Behavior, Animal; Conditioning, Operant; Diazepam; Double-Blind Method; Flunitrazepam; Germany; Humans; Oocytes; Patch-Clamp Techniques; Pentylenetetrazole; Pyrimidines; Rats; Receptors, GABA-A; Saimiri; Tritium; Xenopus laevis | 2005 |
321 other study(ies) available for flunitrazepam and diazepam
| Article | Year |
|---|---|
Electronic factors in the structure-activity relationship of some 1,4-benzodiazepin-2-ones.
Topics: Benzodiazepinones; Electrochemistry; Structure-Activity Relationship | 1977 |
Synthesis and benzodiazepine binding activity of a series of novel [1,2,4]triazolo[1,5-c]quinazolin-5(6H)-ones.
Topics: Animals; Binding, Competitive; Brain; Diazepam; Flunitrazepam; Indicators and Reagents; Molecular Structure; Quinazolines; Rats; Receptors, GABA-A; Structure-Activity Relationship; Triazoles | 1991 |
Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists.
Topics: Administration, Oral; Animals; Benzodiazepines; Chemical Phenomena; Chemistry; Cholecystokinin; Drug Design; Mice; Receptors, Cholecystokinin; Receptors, GABA-A; Structure-Activity Relationship | 1988 |
Design of nonpeptidal ligands for a peptide receptor: cholecystokinin antagonists.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Cholecystokinin; Guinea Pigs; Ligands; Rats; Receptors, Cholecystokinin; Receptors, GABA-A; Structure-Activity Relationship | 1987 |
Quantitative structure-activity relationships employing independent quantum chemical indices.
Topics: Amines; Benzodiazepines; Benzylamines; Mathematics; Quantum Theory; Structure-Activity Relationship; Tetracyclines | 1983 |
Decomposition of pharmacological activity indices into mutually independent components using principal component analysis.
Topics: Animals; Anti-Infective Agents; Benzodiazepines; Hydroxyquinolines; Mathematics; Pharmacology; Rifamycins; Seizures; Statistics as Topic; Structure-Activity Relationship | 1980 |
Prediction of receptor properties and binding affinity of ligands to benzodiazepine/GABAA receptors using artificial neural networks.
Topics: Binding Sites; Ligands; Neural Networks, Computer; Predictive Value of Tests; Receptors, GABA-A; Structure-Activity Relationship | 1995 |
Genetic neural networks for quantitative structure-activity relationships: improvements and application of benzodiazepine affinity for benzodiazepine/GABAA receptors.
Topics: Algorithms; Benzodiazepines; Models, Genetic; Nerve Net; Protein Binding; Receptors, GABA-A; Structure-Activity Relationship | 1996 |
Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach.
Topics: Animals; Benzodiazepines; Carbolines; Cell Line; Columbidae; Conditioning, Operant; Crystallography, X-Ray; Humans; Indoles; Ligands; Male; Models, Molecular; Pyrimidines; Quinolones; Radioligand Assay; Receptors, GABA-A; Saimiri; Stereoisomerism; Structure-Activity Relationship | 2000 |
N-(indol-3-ylglyoxylyl)piperidines: high affinity agonists of human GABA-A receptors containing the alpha1 subunit.
Topics: GABA-A Receptor Agonists; Humans; Indoles; Piperidines; Receptors, GABA-A | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits.
Topics: Adenosine Triphosphate; Allosteric Regulation; Animals; Benzodiazepines; Cells, Cultured; Enzyme Activation; Ethanol; Hippocampus; Humans; Mice; Mice, Knockout; Mutation; Phosphorylation; Protein Kinase C-epsilon; Protein Kinase Inhibitors; Protein Subunits; Pyridines; Receptors, GABA-A; Sensitivity and Specificity; Serine; Zolpidem | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit.
Topics: Animals; Behavior, Animal; Benzodiazepines; Chemical Phenomena; Chemistry, Physical; Computer Simulation; Databases, Factual; Electrophysiology; Female; Ligands; Male; Memory; Mice; Models, Molecular; Molecular Structure; Oocytes; Protein Isoforms; Protein Subunits; Quantitative Structure-Activity Relationship; Receptors, GABA-A; Structure-Activity Relationship; Xenopus laevis | 2008 |
Ethyl 8-fluoro-6-(3-nitrophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate as novel, highly potent, and safe antianxiety agent.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Binding Sites; Brain; Cattle; Computer Simulation; Crystallography, X-Ray; gamma-Aminobutyric Acid; Humans; Hydrogen Bonding; Imidazoles; Mice; Models, Molecular; Molecular Structure; Pentylenetetrazole; Seizures; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate.
Topics: Central Nervous System Agents; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Solubility | 2010 |
New insight into the central benzodiazepine receptor-ligand interactions: design, synthesis, biological evaluation, and molecular modeling of 3-substituted 6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and related compounds.
Topics: Animals; Benzodiazepines; Binding Sites; Binding, Competitive; Cattle; Cerebral Cortex; Chlorides; Flumazenil; HEK293 Cells; Humans; Ligands; Male; Mice; Models, Molecular; Molecular Structure; Motor Activity; Protein Structure, Tertiary; Protein Subunits; Radioligand Assay; Receptors, GABA-A; Synaptosomes; Tritium; Xenopus laevis | 2011 |
Design, Synthesis, and Biological Evaluation of Imidazo[1,5-a]quinoline as Highly Potent Ligands of Central Benzodiazepine Receptors.
Topics: Amnesia; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Binding Sites; Brain; Cattle; Drug Design; Humans; Ischemia; Ligands; Male; Mice; Models, Molecular; Neuroprotective Agents; Quinolines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Structure-Activity Relationship; Synaptosomes | 2016 |
Rationalizing the binding and α subtype selectivity of synthesized imidazodiazepines and benzodiazepines at GABAA receptors by using molecular docking studies.
Topics: Alprazolam; Benzodiazepines; Chlorine; Diazepam; gamma-Aminobutyric Acid; Ion Channels; Ligands; Molecular Docking Simulation; Receptors, GABA; Receptors, GABA-A | 2022 |
Proceedings: Anaesthesia and amnesia with flunitrazepam.
Topics: Amnesia; Anesthesia, General; Anti-Anxiety Agents; Diazepam; Flunitrazepam; Humans | 1976 |
[Effect of combined application of halothane and some central depressants (author's transl)].
Topics: Anesthesia, Inhalation; Animals; Anti-Anxiety Agents; Diazepam; Drug Interactions; Flunitrazepam; Halothane; Male; Medazepam; Mice; Pentobarbital; Posture; Solvents | 1976 |
Effects of two benzodiazepines, phenobarbitone, and baclofen on synaptic transmission in the cat cuneate nucleus.
Topics: Aminobutyrates; Aminooxyacetic Acid; Animals; Anti-Anxiety Agents; Baclofen; Bicuculline; Cats; Diazepam; Drug Interactions; Evoked Potentials; Flunitrazepam; Glutamate Decarboxylase; Medulla Oblongata; Neural Inhibition; Phenobarbital; Picrotoxin; Propionates; Semicarbazides; Synapses; Synaptic Transmission | 1976 |
The amnesic action of diazepam, flunitrazepam and lorazepam in man.
Topics: Amnesia; Anti-Anxiety Agents; Diazepam; Dose-Response Relationship, Drug; Female; Flunitrazepam; Humans; Lorazepam; Time Factors | 1976 |
[Choice of a potentiator of analgesics].
Topics: Amnesia; Analgesics, Opioid; Anesthesia; Anesthetics; Autonomic Nerve Block; Barbiturates; Diazepam; Drug Synergism; Ethanol; Flunitrazepam; Ganglionic Blockers; Halothane; Hemodynamics; Humans; Hypnotics and Sedatives; Nitrous Oxide; Tranquilizing Agents | 1976 |
Diazepam receptor: specific binding of [3H] diazepam and [3H] flunitrazepam to rat brain subfractions.
Topics: Animals; Anti-Anxiety Agents; Brain; Diazepam; Flunitrazepam; In Vitro Techniques; Rats; Receptors, Drug; Synaptosomes | 1978 |
[The effect of flunitrazepam and diazepam on circulation in coronary surgical patients after anesthesia induction and during extracorporeal circulation].
Topics: Anesthesia; Anti-Anxiety Agents; Coronary Vessels; Diazepam; Extracorporeal Circulation; Female; Flunitrazepam; Hemodynamics; Humans; Male; Middle Aged; Sleep; Time Factors | 1978 |
[Administration and dosage of flunitrazepam in combination with regional anesthesia].
Topics: Amnesia; Analgesia; Anesthesia, Conduction; Anesthesia, Spinal; Anti-Anxiety Agents; Diazepam; Drug Combinations; Flunitrazepam; Humans; Nerve Block; Preanesthetic Medication | 1978 |
[Administration and dosage of flunitrazepam in intensive medicine].
Topics: Aged; Anti-Anxiety Agents; Critical Care; Diazepam; Flunitrazepam; Hemodynamics; Humans; Male; Tetanus; Time Factors | 1978 |
Premedication for upper gastrointestinal endoscopy: a comparative study of flunitrazepam, diazepam and neuroleptanalgesia.
Topics: Anti-Anxiety Agents; Diazepam; Digestive System; Endoscopy; Female; Flunitrazepam; Humans; Male; Middle Aged; Neuroleptanalgesia; Premedication | 1978 |
Alterations in the benzodiazepine receptor of Huntington's diseased human brain.
Topics: Aged; Anti-Anxiety Agents; Brain; Cerebellum; Clonazepam; Diazepam; Flunitrazepam; Frontal Lobe; Humans; Huntington Disease; Middle Aged; Putamen; Receptors, Drug | 1979 |
Modulation of benzodiazepine binding sites in calf cortex by an endogenous factor and GABAergic ligands.
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Cattle; Cerebral Cortex; Cycloleucine; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; Nerve Tissue Proteins; Receptors, Drug | 1979 |
Increased specific binding of [3H]diazepam in rat brain following chronic diazepam administration.
Topics: Animals; Anti-Anxiety Agents; Brain; Diazepam; Diet; Flunitrazepam; Male; Rats | 1979 |
[Competitive effect of 2 benzodiazepines: flunitrazepam and diazepam. Demonstration in humans].
Topics: Adjuvants, Anesthesia; Anti-Anxiety Agents; Cerebral Cortex; Diazepam; Drug Interactions; Flunitrazepam; Humans; Receptors, Drug | 1979 |
[Influence of narcotic analgesics, droperidol, diazepam, and flunitrazepam on the smooth muscles of small arteries (author's transl)].
Topics: Analgesics, Opioid; Animals; Antipsychotic Agents; Arteries; Diazepam; Droperidol; Flunitrazepam; Muscle, Smooth; Rats | 1979 |
Putative benzodiazepine receptor: a protein solubilised from brain.
Topics: Animals; Anti-Anxiety Agents; Cell Membrane; Cerebral Cortex; Diazepam; Flunitrazepam; In Vitro Techniques; Kinetics; Rats; Receptors, Drug; Solubility | 1979 |
[High altitude insomnia. Efficacy of flunitrazepam].
Topics: Altitude; Anti-Anxiety Agents; Diazepam; Dose-Response Relationship, Drug; Dyspnea; Flunitrazepam; Humans; Sleep; Sleep Initiation and Maintenance Disorders; Vincamine | 1979 |
Binding of [3H]flunitrazepam to differentiating rat cerebral cells in culture.
Topics: Age Factors; Animals; Anti-Anxiety Agents; Brain; Chlordiazepoxide; Culture Techniques; Diazepam; Flunitrazepam; Neurons; Rats; Receptors, Drug | 1979 |
[Use of Ro5-4200 in bronchoscopy].
Topics: Adult; Aged; Anesthesia, General; Anesthetics, Local; Anti-Anxiety Agents; Atropine; Bronchoscopy; Cardiovascular System; Diazepam; Female; Flunitrazepam; Humans; Male; Middle Aged; Muscles; Preanesthetic Medication; Respiration | 1979 |
Benzodiazepine receptors: effect of tissue preincubation at 37 degrees C.
Topics: Animals; Anti-Anxiety Agents; Brain; Diazepam; Flunitrazepam; In Vitro Techniques; Rats; Receptors, Drug; Temperature | 1979 |
[Histamine liberation by flunitrazepam].
Topics: Adult; Anaphylaxis; Anti-Anxiety Agents; Diazepam; Female; Flunitrazepam; Histamine; Histamine Release; Humans; Hypersensitivity; Male; Time Factors | 1978 |
[Induction of anaesthesia in patients with coronary artery disease: flunitrazepam, diazepam, ketamine, fentanyl. A haemodynamic study (author's transl)].
Topics: Adult; Aged; Anesthetics; Coronary Artery Bypass; Coronary Disease; Diazepam; Fentanyl; Flunitrazepam; Hemodynamics; Humans; Intubation, Intratracheal; Ketamine; Middle Aged; Succinylcholine | 1979 |
[Intravenous anesthetics as an introduction of general anesthesia in patients with complicating disease of the respiratory and circulatory systems].
Topics: Alfaxalone Alfadolone Mixture; Anesthesia, Intravenous; Cardiovascular Diseases; Diazepam; Flunitrazepam; Humans; Ketamine; Methohexital; Propanidid; Respiratory Tract Diseases; Thiopental | 1979 |
Variable premedication for upper gastrointestinal endoscopy.
Topics: Diazepam; Droperidol; Drug Combinations; Flunitrazepam; Gastroscopy; Humans; Lidocaine; Nitrous Oxide; Oxygen; Premedication; Propantheline | 1979 |
GABA receptors in clonal cell lines: a model for study of benzodiazepine action at molecular level.
Topics: Animals; Benzodiazepines; Brain; Cell Line; Clonazepam; Clone Cells; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; Membrane Proteins; Mice; Nerve Tissue Proteins; Rats; Receptors, Drug | 1979 |
Acute diazepam administration produces rapid increases in brain benzodiazepine receptor density.
Topics: Animals; Benzodiazepines; Brain; Diazepam; Flunitrazepam; In Vitro Techniques; Kinetics; Male; Rats; Receptors, Drug | 1979 |
Brain specific benzodiazepine receptors.
Topics: Animals; Benzodiazepines; Brain; Diazepam; Flunitrazepam; Membranes; Rats; Receptors, Drug; Temperature | 1978 |
[Tetanus: 10 years of experience].
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Diazepam; Female; Flunitrazepam; Humans; Infant; Intubation, Intratracheal; Male; Middle Aged; Pancuronium; Phenobarbital; Tetanus; Tracheotomy | 1978 |
[Interactions between nitrous oxide and central depressants].
Topics: Animals; Barbiturates; Benzodiazepines; Diazepam; Drug Interactions; Drug Synergism; Ethanol; Flunitrazepam; Male; Medazepam; Mice; Nitrous Oxide | 1979 |
Determination of 1,4-benzodiazepines and -diazepin-2-ones in blood by electron-capture gas-liquid chromatography.
Topics: Benzodiazepines; Benzodiazepinones; Bromazepam; Chromatography, Gas; Clonazepam; Diazepam; Flunitrazepam; Humans | 1976 |
Responses to intravenous sedation by elderly patients at the Hokkaido University Dental Hospital.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Anesthesia, Dental; Benzodiazepines; Blood Pressure; Conscious Sedation; Dental Care for Aged; Diazepam; Flunitrazepam; Heart Rate; Humans; Injections, Intravenous; Middle Aged; Oximetry; Oxygen | 1992 |
Evidence for more than two central benzodiazepine receptors in rat spinal cord.
Topics: Animals; Binding, Competitive; Diazepam; Flumazenil; Flunitrazepam; Rats; Receptors, GABA-A; RNA, Messenger; Spinal Cord | 1992 |
Acute handling stress downregulates benzodiazepine receptors: reversal by diazepam.
Topics: Animals; Cerebral Cortex; Diazepam; Down-Regulation; Flunitrazepam; Handling, Psychological; Male; Rats; Receptors, GABA-A; Stress, Psychological | 1992 |
Effect of diethyl pyrocarbonate modification of benzodiazepine receptors on [3H]Ro 15-4513 binding.
Topics: Animals; Appetite Depressants; Azides; Benzodiazepines; Carbolines; Cerebellum; Cerebral Cortex; Diazepam; Diethyl Pyrocarbonate; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Tritium | 1992 |
Characterization of two cerebellar binding sites of [3H]Ro 15-4513.
Topics: Animals; Azides; Benzodiazepines; Binding Sites; Cell Membrane; Cerebellum; Chromatography, Affinity; Diazepam; Flunitrazepam; Receptors, GABA-A; Swine; Tritium | 1992 |
Immortalized hypothalamic GT1-7 neurons express functional gamma-aminobutyric acid type A receptors.
Topics: Anesthetics; Animals; Barbiturates; Base Sequence; Bicuculline; Cell Line, Transformed; Cell Membrane; Chloride Channels; Diazepam; Electrophysiology; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression Regulation; Hypothalamus; Membrane Proteins; Mice; Molecular Sequence Data; Muscimol; Neurons; Peptides; Polymerase Chain Reaction; Receptors, GABA-A; RNA, Messenger; Sensitivity and Specificity; Steroids; Tritium; Tumor Cells, Cultured; Zinc | 1992 |
Amino acid neurotransmitter receptor changes in cerebral cortex in alcoholism: effect of cirrhosis of the liver.
Topics: Adult; Benzodiazepines; Binding Sites; Cerebral Cortex; Diazepam; Dizocilpine Maleate; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Liver Cirrhosis, Alcoholic; Male; Middle Aged; Receptors, Amino Acid; Receptors, Neurotransmitter | 1992 |
Polyamines modulate the binding of GABAA-benzodiazepine receptor ligands in membranes from the rat forebrain.
Topics: Animals; Biogenic Polyamines; Diazepam; Flunitrazepam; In Vitro Techniques; Ligands; Male; Membranes; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1992 |
Sex differences in sensitivity to pentylenetetrazol but not in GABAA receptor binding.
Topics: Anesthetics; Animals; Anticonvulsants; Autoradiography; Benzodiazepinones; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Diazepam; Electroshock; Ethanol; Female; Flunitrazepam; Male; Muscimol; Orchiectomy; Ovariectomy; Pentylenetetrazole; Pregnanediones; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Sex Characteristics | 1992 |
Central and peripheral benzodiazepine receptors in rat brain and platelets: effects of treatment with diazepam and clobazam.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Blood Platelets; Brain; Clobazam; Diazepam; Drug Tolerance; Flunitrazepam; Injections, Intraperitoneal; Isoquinolines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1992 |
Comparative study of interaction mode of diazepines with human serum albumin and alpha 1-acid glycoprotein.
Topics: Anti-Anxiety Agents; Bromazepam; Clonazepam; Diazepam; Flunitrazepam; Humans; Orosomucoid; Oxazepam; Protein Binding; Regression Analysis; Serum Albumin; Spectrometry, Fluorescence | 1992 |
Influences of gender, gonadectomy, and estrous cycle on GABA/BZ receptors and benzodiazepine responses in rats.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Bicuculline; Brain; Brain Chemistry; Diazepam; Estrus; Female; Flunitrazepam; Male; Orchiectomy; Ovariectomy; Radioimmunoassay; Radioligand Assay; Rats; Receptors, GABA-A; Sex Characteristics | 1992 |
Effects of lorazepam tolerance and withdrawal on GABAA receptor-operated chloride channels.
Topics: Animals; Appetite Depressants; Binding Sites; Brain; Carbolines; Chloride Channels; Chlorides; Diazepam; Drug Interactions; Ethanol; Flunitrazepam; Ion Channels; Lorazepam; Male; Membrane Proteins; Mice; Mice, Inbred ICR; Phenobarbital; Receptors, GABA-A | 1992 |
Locomotor responses to benzodiazepines, barbiturates and ethanol in diazepam-sensitive (DS) and -resistant (DR) mice.
Topics: Analysis of Variance; Animals; Diazepam; Dose-Response Relationship, Drug; Ethanol; Female; Flumazenil; Flunitrazepam; Male; Mice; Motor Activity; Pentobarbital; Phenobarbital | 1992 |
Different pharmacodynamics for diazepam and flunitrazepam?
Topics: Adult; Choice Behavior; Diazepam; Double-Blind Method; Ethanol; Flunitrazepam; Humans; Reaction Time | 1992 |
Comparison of the relaxant effects of diazepam, flunitrazepam and midazolam on airway smooth muscle.
Topics: Animals; Atropine; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug; Flunitrazepam; Guinea Pigs; Male; Midazolam; Muscle Relaxation; Muscle, Smooth; Propranolol; Trachea | 1992 |
gamma-Aminobutyric acid-activated chloride channels in rats selectively bred for differential acute sensitivity to alcohol.
Topics: Alcohol Drinking; Animals; Chloride Channels; Diazepam; Female; Flunitrazepam; gamma-Aminobutyric Acid; Membrane Proteins; Muscimol; Pentobarbital; Phenobarbital; Phenotype; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Selection, Genetic | 1991 |
The gamma 3-subunit of the GABAA-receptor confers sensitivity to benzodiazepine receptor ligands.
Topics: Amino Acid Sequence; Animals; Base Sequence; Benzodiazepines; Brain; Cloning, Molecular; Diazepam; Dose-Response Relationship, Drug; Flunitrazepam; gamma-Aminobutyric Acid; Molecular Sequence Data; Rats; Receptors, GABA-A | 1991 |
Acoustic startle induced ultrasonic vocalization in the rat: a novel animal model of anxiety?
Topics: Animals; Anti-Anxiety Agents; Anxiety; Appetite Depressants; Arousal; Carbolines; Diazepam; Disease Models, Animal; Electroshock; Fear; Flunitrazepam; Male; Maprotiline; Pyrimidines; Rats; Rats, Inbred Strains; Reflex, Startle; Ultrasonics; Vocalization, Animal | 1991 |
Role of cGMP in the mechanism of anxiolytic activity of U-78875.
Topics: Animals; Anti-Anxiety Agents; Binding, Competitive; Brain Chemistry; Carbolines; Cerebellum; Convulsants; Cyclic GMP; Diazepam; Dose-Response Relationship, Drug; Electroshock; Flunitrazepam; Male; Mice; Muscimol; Oxadiazoles; Quinoxalines; Rats; Rats, Inbred Strains; Stress, Psychological | 1991 |
Failure of gamma-hydroxybutyrate to alter the function of the GABAA receptor complex in the rat cerebral cortex.
Topics: Animals; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chlorides; Diazepam; Flunitrazepam; In Vitro Techniques; Ion Channels; Isoniazid; Male; Nerve Tissue Proteins; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sodium Oxybate; Synaptic Transmission | 1991 |
In vitro inhibition studies of the glucuronidation of 3'-azido-3'-deoxythymidine catalysed by human liver UDP-glucuronosyl transferase.
Topics: Acquired Immunodeficiency Syndrome; Diazepam; Didanosine; Dose-Response Relationship, Drug; Flunitrazepam; Glucuronosyltransferase; Humans; Kinetics; Microsomes, Liver; Morphine; Naproxen; Zidovudine | 1992 |
In vitro effect of additives in benzodiazepine solutions on the superoxide anion-generating system in polymorphonuclear leucocytes.
Topics: Animals; Anions; Benzyl Alcohol; Benzyl Alcohols; Depression, Chemical; Diazepam; Ethanol; Flunitrazepam; Humans; In Vitro Techniques; Neutrophils; Pharmaceutic Aids; Propylene Glycol; Propylene Glycols; Superoxides; Swine | 1991 |
Kinetics of the acid hydrolysis of diazepam, bromazepam, and flunitrazepam in aqueous and micellar systems.
Topics: Bromazepam; Chromatography, High Pressure Liquid; Diazepam; Flunitrazepam; Hydrocarbons; Hydrolysis; Kinetics; Micelles; Sodium Dodecyl Sulfate; Spectrophotometry, Ultraviolet; Surface-Active Agents | 1991 |
A comparison of the physical dependence inducing properties of flunitrazepam and diazepam.
Topics: Animals; Biotransformation; Blood Proteins; Brain Chemistry; Diazepam; Dogs; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; Protein Binding; Seizures; Substance Withdrawal Syndrome; Substance-Related Disorders | 1991 |
[Premedication and analgesic dose procedures in dental medicine].
Topics: Anesthesia, Dental; Anesthesia, Local; Buprenorphine; Clorazepate Dipotassium; Diazepam; Flunitrazepam; Humans; Lorazepam; Meperidine; Midazolam; Morphine; Oxazepam; Pain; Pentazocine; Pirinitramide; Preanesthetic Medication | 1991 |
GABAA/benzodiazepine receptor localization in the circadian timing system.
Topics: Animals; Autoradiography; Axons; Circadian Rhythm; Cricetinae; Diazepam; Flunitrazepam; Geniculate Bodies; Glial Fibrillary Acidic Protein; Glutamate Decarboxylase; Immunoenzyme Techniques; Mesocricetus; Neurons; Neuropeptide Y; Organ Specificity; Raphe Nuclei; Rats; Rats, Inbred Strains; Receptors, GABA-A; Species Specificity; Suprachiasmatic Nucleus; Tritium | 1990 |
Relative efficacies of benzodiazepine receptor agonists in affecting red nucleus electrical activity in rabbits.
Topics: Animals; Bicuculline; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; Imidazoles; Isoquinolines; Male; Pentylenetetrazole; Pyridazines; Pyridines; Rabbits; Receptors, GABA-A; Red Nucleus; Zolpidem | 1990 |
Effects of GABA and anxiolytics on the single unit discharge of suprachiasmatic neurons in rat hypothalamic slices.
Topics: Animals; Anti-Anxiety Agents; Azabicyclo Compounds; Baclofen; Bicuculline; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; Hypothalamus; In Vitro Techniques; Muscimol; Neurons; Piperazines; Rats; Receptors, GABA-A; Suprachiasmatic Nucleus | 1990 |
CGS 20625, a novel pyrazolopyridine with selective anxiolytic activity.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Biological Availability; Diazepam; Flunitrazepam; Learning; Male; Motor Activity; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter | 1990 |
Characterization by saturation studies of the in vivo binding of [3H]flunitrazepam in mouse brain.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Clonazepam; Diazepam; Flunitrazepam; Kinetics; Mice; Nordazepam; Oxazepam | 1991 |
A comparison between the effects of acute doses of ethanol, diazepam and flunitrazepam on psychomotor performance.
Topics: Adolescent; Adult; Diazepam; Dose-Response Relationship, Drug; Ethanol; Flunitrazepam; Humans; Male; Psychomotor Performance; Time Factors | 1990 |
Soman- or kainic acid-induced convulsions decrease muscarinic receptors but not benzodiazepine receptors.
Topics: Animals; Autoradiography; Diazepam; Flunitrazepam; Kainic Acid; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Muscarinic; Seizures; Soman; Tritium; Video Recording | 1990 |
Peripheral-type benzodiazepine receptors are highly concentrated in mitochondrial membranes of rat testicular interstitial cells.
Topics: Animals; Benzodiazepinones; Binding, Competitive; Diazepam; Flunitrazepam; Intracellular Membranes; Isoquinolines; Kinetics; Leydig Cells; Male; Mitochondria; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1990 |
Cyclopyrrolones, unlike some benzodiazepines, do not induce physical dependence in mice.
Topics: Animals; Azabicyclo Compounds; Carbolines; Convulsants; Diazepam; Disease Models, Animal; Flunitrazepam; Hypnotics and Sedatives; Lorazepam; Male; Mice; Mice, Inbred Strains; Naphthyridines; Piperazines; Seizures; Structure-Activity Relationship; Substance-Related Disorders; Sulfur Compounds; Triazolam | 1990 |
Long-term diazepam treatment produces changes in cholecystokinin receptor binding in rat brain.
Topics: Animals; Behavior, Animal; Brain Chemistry; Cholecystokinin; Diazepam; Exploratory Behavior; Flunitrazepam; In Vitro Techniques; Male; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Substance Withdrawal Syndrome; Synaptosomes | 1990 |
1,4-Benzodiazepines antagonize opiate-induced antinociception in mice.
Topics: Analgesia; Animals; Buprenorphine; Diazepam; Dose-Response Relationship, Drug; Fentanyl; Flunitrazepam; Male; Mice; Midazolam; Morphine; Narcotic Antagonists; Psychomotor Performance | 1990 |
[New aspects of diagnostic criteria in BERA tests].
Topics: Acoustic Stimulation; Adolescent; Adult; Audiometry, Evoked Response; Brain Stem; Diazepam; Female; Flunitrazepam; Humans; Male; Middle Aged | 1990 |
Genetic selection for benzodiazepine ataxia produces functional changes in the gamma-aminobutyric acid receptor chloride channel complex.
Topics: Animals; Ataxia; Chlorides; Diazepam; Ethanol; Flunitrazepam; Ion Channels; Isoxazoles; Mice; Muscimol; Phenobarbital; Receptors, GABA-A; Time Factors | 1988 |
Regional GABA/benzodiazepine receptor/chloride channel coupling after acute and chronic benzodiazepine treatment.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Bicuculline; Brain; Chlorides; Diazepam; Flunitrazepam; Flurazepam; gamma-Aminobutyric Acid; Ion Channels; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stimulation, Chemical | 1989 |
Radioreceptor assay of clonazepam and diazepam in blood for therapeutic drug monitoring.
Topics: Adolescent; Animals; Child; Child, Preschool; Chromatography, Gas; Chromatography, High Pressure Liquid; Clonazepam; Diazepam; Flunitrazepam; Humans; Male; Nordazepam; Radioligand Assay; Rats | 1989 |
Postnatal evolution of the gamma-aminobutyric acid/benzodiazepine receptor complex in a model of inherited epilepsy: the quaking mouse.
Topics: Aging; Animals; Brain; Brain Stem; Cerebellum; Diazepam; Diencephalon; Epilepsy; Flunitrazepam; gamma-Aminobutyric Acid; Mice; Mice, Inbred C57BL; Mice, Quaking; Muscimol; Receptors, GABA-A; Telencephalon | 1989 |
The ontogeny of benzodiazepine receptors in selected regions of the rat brain: effect of perinatal exposure to diazepam.
Topics: Animals; Brain; Brain Chemistry; Diazepam; Female; Flunitrazepam; Nerve Tissue Proteins; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Receptors, GABA-A | 1989 |
The relationship of benzodiazepine binding sites to the norepinephrine projection in the hypothalamus of the adult rat.
Topics: Animals; Diazepam; Flumazenil; Flunitrazepam; Hypothalamus; Norepinephrine; Rats; Receptors, GABA-A | 1989 |
Type I and type II GABAA-benzodiazepine receptors produced in transfected cells.
Topics: Cell Line; Diazepam; Flumazenil; Flunitrazepam; Humans; Molecular Weight; Pyridazines; Receptors, GABA-A; Recombinant Proteins; Transfection | 1989 |
Non-benzodiazepine, Ag-dependent, brain-specific binding sites for [3H]beta-carboline-3-carboxylic acid ethyl ester.
Topics: Animals; Binding Sites; Brain; Carbolines; Diazepam; Flunitrazepam; In Vitro Techniques; Kinetics; Male; Membranes; Rats; Receptors, GABA-A; Silver | 1989 |
Relationship between the pharmacological effects of benzodiazepines and their in vivo binding sites in the brain of rats.
Topics: Animals; Brain Stem; Cerebral Cortex; Diazepam; Flunitrazepam; Hypothalamus; Phenobarbital; Rats; Receptors, GABA-A | 1989 |
[Inhibition of neutrophil function by solvent of injectable sedatives--effects of propylene glycol, ethanol and benzyl alcohol].
Topics: Benzyl Alcohol; Benzyl Alcohols; Benzyl Compounds; Diazepam; Ethanol; Flunitrazepam; Humans; In Vitro Techniques; Neutrophils; Oxygen; Propylene Glycol; Propylene Glycols; Solvents | 1989 |
Effects of chlordiazepoxide, chlorpromazine, diazepam, diphenylhydantoin, flunitrazepam and haloperidol on the voltage-dependent sodium current of isolated mammalian brain neurons.
Topics: Animals; Chlordiazepoxide; Chlorpromazine; Diazepam; Flunitrazepam; Haloperidol; Hippocampus; In Vitro Techniques; Membrane Potentials; Phenytoin; Psychotropic Drugs; Rats; Sodium | 1989 |
Synthesis and binding study on pyrazolo[4,5-c] [1,8]naphthyridines.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Chemical Phenomena; Chemistry; Diazepam; Flunitrazepam; In Vitro Techniques; Naphthyridines; Pyrazoles; Rats; Receptors, GABA-A; Synaptic Membranes | 1987 |
Heterogeneity of gamma-aminobutyric acid/benzodiazepine/beta-carboline receptor complex in rat spinal cord.
Topics: Animals; Bicuculline; Binding, Competitive; Carbolines; Cerebellum; Diazepam; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Male; Muscimol; Rats; Receptors, GABA-A; Spinal Cord; Synaptic Membranes | 1988 |
Nonequilibrium modulation of 35S-TBPS binding by benzodiazepine agonists and antagonists.
Topics: Animals; Benzodiazepines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Diazepam; Flunitrazepam; In Vitro Techniques; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Structure-Activity Relationship | 1988 |
Specificity within the GABAA receptor supramolecular complex: a consideration of the new omega 1-receptor selective imidazopyridine hypnotic zolpidem.
Topics: Animals; Diazepam; Flunitrazepam; Hypnotics and Sedatives; Male; Mice; Mice, Inbred Strains; Pyridines; Receptors, GABA-A; Zolpidem | 1988 |
Modulation of benzodiazepine by lysine and pipecolic acid on pentylenetetrazol-induced seizures.
Topics: Animals; Biological Transport; Brain; Diazepam; Dose-Response Relationship, Drug; Flunitrazepam; Lysine; Male; Mice; Pentylenetetrazole; Pipecolic Acids; Receptors, GABA-A; Seizures | 1988 |
In vivo binding of (3H)Ro 15-1788 in mice: comparison with the in vivo binding of (3H)flunitrazepam.
Topics: Animals; Brain; Cerebellum; Cerebral Cortex; Diazepam; Flumazenil; Flunitrazepam; Hippocampus; Male; Mice; Receptors, GABA-A | 1988 |
Chronic administration of diazepam downregulates adenosine receptors in the rat brain.
Topics: Animals; Brain; Diazepam; Flumazenil; Flunitrazepam; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Purinergic | 1988 |
Rapid internalization of benzodiazepine receptors in the rat cortex induced by handling.
Topics: Animals; Bicuculline; Carbolines; Cerebral Cortex; Corticosterone; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Ligands; Male; Rats; Receptors, GABA-A; Stress, Physiological; Synaptic Membranes; Viscosity | 1988 |
Desensitization of adenosine A2 receptors in the striatum of the rat following chronic treatment with diazepam.
Topics: Adenylyl Cyclases; Animals; Cerebral Cortex; Corpus Striatum; Diazepam; Electroencephalography; Flunitrazepam; Hippocampus; Male; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Purinergic; Sleep | 1988 |
Animal models of chronic anxiety and "fearlessness".
Topics: Animals; Anxiety; Brain; Cats; Diazepam; Disease Models, Animal; Fear; Female; Flumazenil; Flunitrazepam; Male; Pregnancy; Prenatal Exposure Delayed Effects; Receptors, GABA-A | 1988 |
Behavioral differences in an elevated plus-maze: correlation between anxiety and decreased number of GABA and benzodiazepine receptors in mouse cerebral cortex.
Topics: Animals; Anxiety; Brain; Carbolines; Cerebral Cortex; Diazepam; Exploratory Behavior; Flunitrazepam; Male; Mice; Muscimol; Receptors, GABA-A | 1988 |
Necropsy study of GABA/benzodiazepine receptor binding sites in brain tissue from chronic alcoholic patients.
Topics: Alcoholism; Brain; Diazepam; Flunitrazepam; Humans; Receptors, GABA-A | 1988 |
Benzodiazepine antagonist Ro 15-1788 in self-poisoning. Diagnostic and therapeutic use.
Topics: Adult; Aged; Anti-Anxiety Agents; Antidotes; Benzodiazepinones; Coma; Diazepam; Electroencephalography; Female; Flumazenil; Flunitrazepam; Humans; Male; Middle Aged; Naloxone; Suicide, Attempted | 1985 |
Tolerance to the anticonvulsant action of benzodiazepines. Relationship to decreased receptor density.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Binding, Competitive; Diazepam; Drug Tolerance; Flunitrazepam; Male; Pentylenetetrazole; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1985 |
Selective interaction of novel anxiolytics with 5-hydroxytryptamine1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Binding, Competitive; Brain; Buspirone; Cattle; Depression, Chemical; Diazepam; Flunitrazepam; In Vitro Techniques; Lorazepam; Pyrimidines; Receptors, Serotonin; Tetrahydronaphthalenes | 1985 |
In vivo interaction of premazepam with benzodiazepine receptors: relation to its pharmacological effects.
Topics: Animals; Anti-Anxiety Agents; Azepines; Diazepam; Flunitrazepam; Male; Rats; Receptors, GABA-A; Tritium | 1985 |
Neuroanatomical site of the inhibitory influence of anxiolytic drugs on central serotonergic transmission.
Topics: Animals; Anti-Anxiety Agents; Azabicyclo Compounds; Central Nervous System; Cerebellum; Corpus Striatum; Diazepam; Flunitrazepam; Frontal Lobe; Hippocampus; Male; Piperazines; Rats; Rats, Inbred Strains; Serotonin; Synaptic Transmission | 1986 |
Possible destruction of cholinoceptive neurons by overstimulation of cholinergic tracts.
Topics: Animals; Brain; Choline O-Acetyltransferase; Cholinergic Fibers; Diazepam; Epilepsy; Flunitrazepam; Glutamate Decarboxylase; Histocytochemistry; Male; Neurons; Pons; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Scopolamine; Tyrosine 3-Monooxygenase | 1986 |
Neurotransmitter changes during development of cortical neuronal cultures.
Topics: Animals; Benzodiazepinones; Cells, Cultured; Cerebral Cortex; Choline O-Acetyltransferase; Clonazepam; Diazepam; Fetus; Flunitrazepam; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Mice; Neurotransmitter Agents | 1986 |
Behavioral studies with anxiolytic drugs. III. Antipunishment actions of buspirone in the pigeon do not involve benzodiazepine receptor mechanisms.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Buspirone; Chlordiazepoxide; Columbidae; Diazepam; Flumazenil; Flunitrazepam; Punishment; Pyrimidines; Receptors, GABA-A | 1986 |
Aging: effect on ex-vivo benzodiazepine binding after a diazepam injection.
Topics: Aging; Animals; Anti-Anxiety Agents; Binding, Competitive; Brain; Diazepam; Flunitrazepam; Kinetics; Male; Pyridazines; Rats; Rats, Inbred F344; Receptors, GABA-A | 1987 |
Modulation of GABA-stimulated chloride influx into membrane vesicles from rat cerebral cortex by benzodiazepines and nonbenzodiazepines.
Topics: Animals; Anti-Anxiety Agents; Cell Membrane; Cerebral Cortex; Chlorides; Clonazepam; Diazepam; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Rats; Rats, Inbred Strains | 1988 |
[Abuse of licit drugs in heroin addicts].
Topics: Adolescent; Adult; Anti-Anxiety Agents; Diazepam; Female; Flunitrazepam; Heroin Dependence; Humans; Lorazepam; Male; Substance-Related Disorders; Surveys and Questionnaires | 1987 |
Ro 16-6028: a novel anxiolytic acting as a partial agonist at the benzodiazepine receptor.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Benzodiazepinones; Cats; Conflict, Psychological; Cyclic GMP; Diazepam; Dogs; Flunitrazepam; Mice; Rats; Receptors, GABA-A; Saimiri; Substance Withdrawal Syndrome | 1988 |
Chronic diazepam treatment produces regionally specific changes in GABA-stimulated chloride influx.
Topics: Animals; Cerebellum; Cerebral Cortex; Chlorides; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; Male; Membranes; Rats; Rats, Inbred Strains | 1989 |
The effects of benzodiazepines as anaesthesia inducing agents on plasma cortisol level in elective hysterectomy.
Topics: Adjuvants, Anesthesia; Adult; Analysis of Variance; Anesthesia, General; Benzodiazepines; Blood Pressure; Diazepam; Female; Flunitrazepam; Humans; Hydrocortisone; Hysterectomy; Midazolam; Middle Aged; Pulse; Stress, Physiological | 1985 |
Effects of guanyl nucleotides on [3H]flunitrazepam binding to rat hippocampal synaptic membranes: equilibrium binding and dissociation kinetics.
Topics: Adenosine Triphosphate; Animals; Benzodiazepinones; Diazepam; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Guanine Nucleotides; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Hippocampus; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptic Membranes | 1985 |
Benzodiazepine receptors and seizure susceptibility in epileptic fowl.
Topics: Animals; Animals, Newborn; Brain Chemistry; Chickens; Diazepam; Epilepsy; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Heterozygote; In Vitro Techniques; Kinetics; Membranes; Photic Stimulation; Receptors, GABA-A | 1985 |
Synthesis and interaction of 5-(substituted-phenyl)-3-methyl-6,7-dihydropyrazolo[4,3-e] [1,4]diazepin-8(7H)-ones with benzodiazepine receptors in rat cerebral cortex.
Topics: Animals; Azepines; Binding, Competitive; Cerebral Cortex; Chlordiazepoxide; Diazepam; Flunitrazepam; In Vitro Techniques; Male; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Structure-Activity Relationship | 1985 |
Enhancement of brain [3H]flunitrazepam binding and analgesic activity of synthetic cannabimimetics.
Topics: Analgesics; Animals; Anticonvulsants; Brain; Calcium; Cannabinoids; Cerebellum; Cyclic GMP; Diazepam; Dronabinol; Flunitrazepam; Male; Mice; Rats; Rats, Inbred Strains; Receptors, GABA-A; Tritium | 1985 |
Radiation inactivation studies of the benzodiazepine/gamma-aminobutyric acid/chloride ionophore receptor complex.
Topics: Animals; Barbiturates; Benzodiazepines; Benzodiazepinones; Binding Sites; Brain; Carbolines; Cell Membrane; Chlorides; Diazepam; Flumazenil; Flunitrazepam; Ionophores; Male; Molecular Weight; Muscimol; Picrotoxin; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1985 |
Further characterization of [3H] flunitrazepam binding sites on cultured mouse astroglia.
Topics: Animals; Astrocytes; Binding Sites; Bucladesine; Cells, Cultured; Diazepam; Flunitrazepam; Kinetics; Ligands; Membranes; Mice; Receptors, GABA-A; Serotonin | 1985 |
Pharmacological and neurochemical aspects of kindling.
Topics: Alanine; Amino Acids; Amygdala; Animals; Diazepam; Electric Stimulation; Flunitrazepam; Kindling, Neurologic; Male; Placebos; Rats; Receptors, GABA-A; Tritium | 1985 |
Benzodiazepine/gamma-aminobutyric acid receptor deficit in the midbrain of the seizure-susceptible gerbil.
Topics: Animals; Bicuculline; Diazepam; Disease Models, Animal; Flunitrazepam; Gerbillinae; Mesencephalon; Muscimol; Pentobarbital; Receptors, GABA-A; Seizures | 1985 |
Monoclonal antibodies to benzodiazepines.
Topics: Animals; Anti-Anxiety Agents; Antibodies, Monoclonal; Benzodiazepines; Benzodiazepinones; Diazepam; Flumazenil; Flunitrazepam; Flurazepam; Mice; Mice, Inbred BALB C; Receptors, GABA-A; Structure-Activity Relationship | 1985 |
Autoradiographic localization of benzodiazepine receptor downregulation.
Topics: Animals; Autoradiography; Brain Chemistry; Diazepam; Flunitrazepam; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Tritium | 1986 |
Biochemical studies with the new thienotriazolo-diazepine brotizolam.
Topics: Animals; Azepines; Binding, Competitive; Biogenic Amines; Diazepam; Dopamine; Flunitrazepam; Homovanillic Acid; Hypnotics and Sedatives; In Vitro Techniques; Male; Rats; Receptors, Drug; Receptors, GABA-A; Synaptosomes | 1986 |
Comparison of benzodiazepine receptors in cerebellum and inferior colliculus.
Topics: Aging; Animals; Animals, Newborn; Carbolines; Cell Membrane; Cerebellum; Clonazepam; Diazepam; Flunitrazepam; Inferior Colliculi; Pyridazines; Rats; Receptors, GABA-A | 1986 |
Evidence of specific benzodiazepine binding to myometrial membrane preparations from human pregnant uterus.
Topics: Adult; Benzodiazepines; Benzodiazepinones; Cell Membrane; Chlordiazepoxide; Diazepam; Female; Flunitrazepam; Humans; Lorazepam; Myometrium; Pregnancy; Receptors, Cell Surface | 1986 |
A 7-phenyl substituted triazolopyridazine has inverse agonist activity at the benzodiazepine receptor site.
Topics: Animals; Binding, Competitive; Brain; Conditioning, Operant; Convulsants; Diazepam; Female; Flumazenil; Flunitrazepam; In Vitro Techniques; Male; Mice; Pyridazines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Structure-Activity Relationship | 1987 |
Pyrethroid insecticides and radioligand displacement from the GABA receptor chloride ionophore complex.
Topics: Animals; Binding, Competitive; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Diazepam; Flunitrazepam; Male; Muscimol; Nitriles; Permethrin; Pyrethrins; Rats; Receptors, GABA-A | 1987 |
A retrospective study of drugged driving in Norway.
Topics: Adolescent; Adult; Age Factors; Amphetamine; Automobile Driving; Diazepam; Dronabinol; Ethanol; Female; Flunitrazepam; Humans; Male; Meprobamate; Middle Aged; Morphine; Norway; Retrospective Studies; Substance-Related Disorders; Toluene | 1987 |
[Independent benzodiazepine and beta-carboline binding sites in the brain of aggressive and anxious-defensive mice].
Topics: Aggression; Animals; Anxiety; Binding Sites; Brain; Carbolines; Diazepam; Flunitrazepam; Ligands; Male; Mice; Receptors, GABA-A; Tritium | 1987 |
Comparative study in mice of flunitrazepam vs. diazepam on morphine withdrawal syndrome.
Topics: Animals; Behavior, Animal; Diazepam; Flunitrazepam; Male; Mice; Mice, Inbred Strains; Morphine; Morphine Dependence; Naloxone; Substance Withdrawal Syndrome | 1988 |
[Hyperkinetic effects of flunitrazepam and diazepam on the fetus].
Topics: Diazepam; Drug Interactions; Female; Fetal Movement; Flunitrazepam; Heart Rate; Humans; Hyperkinesis; Ketamine; Pregnancy | 1987 |
Peptide derivatives as prodrugs.
Topics: Amino Acids; Animals; Bacteria; Biological Availability; Biological Transport, Active; Chlordiazepoxide; Diazepam; Flunitrazepam; Flurazepam; Humans; Kinetics; Nitrazepam; Papio; Rats | 1986 |
The antimitotic activities of some benzodiazepines.
Topics: Benzodiazepines; Chlorophyta; Chromosomes; Clonazepam; Diazepam; Flunitrazepam; Medazepam; Mitosis; Nitrazepam | 1986 |
Resumption of sinus rhythm during general anaesthesia in an elderly patient with chronic atrial fibrillation: a case report.
Topics: Aged; Anesthesia, Endotracheal; Atrial Fibrillation; Diazepam; Enflurane; Fentanyl; Flunitrazepam; Humans; Male; Neuroleptanalgesia; Nitrous Oxide; Pancuronium; Remission, Spontaneous | 1986 |
Hemodynamic effects of diazepam, flunitrazepam, and midazolam in patients with ischemic heart disease: assessment with a radionuclide approach.
Topics: Adult; Aged; Aged, 80 and over; Coronary Disease; Coronary Vessels; Diazepam; Flunitrazepam; Hemodynamics; Humans; Midazolam; Middle Aged; Radionuclide Imaging; Stroke Volume | 1986 |
Characterization of peripheral-type benzodiazepine recognition sites in the rat spinal cord.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Binding Sites; Brain; Diazepam; Flunitrazepam; Kinetics; Male; Rats; Rats, Inbred Strains; Spinal Cord | 1985 |
[Clinical experiences with Ro 05-4200 in anaesthesia(author's transl)].
Topics: Adolescent; Adult; Aged; Amnesia; Anesthetics; Anti-Anxiety Agents; Blood Pressure; Chemical Phenomena; Chemistry; Diazepam; Droperidol; Female; Flunitrazepam; Humans; Male; Middle Aged; Nitrazepam; Preanesthetic Medication; Pulse; Sleep; Vasodilator Agents | 1974 |
In vitro interaction of premazepam with benzodiazepine receptors in rat brain regions.
Topics: Animals; Azepines; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Brain; Cerebellum; Convulsants; Diazepam; Flumazenil; Flunitrazepam; Kinetics; Male; Organ Specificity; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Synaptosomes; Thermodynamics | 1984 |
In vivo determination of efficacy of pyrazoloquinolinones at the benzodiazepine receptor.
Topics: Animals; Binding, Competitive; Brain; Convulsants; Diazepam; Flunitrazepam; Male; Mice; Pentylenetetrazole; Pyrazoles; Receptors, GABA-A | 1984 |
Flunitrazepam binding to intact and homogenized astrocytes and neurons in primary cultures.
Topics: Animals; Astrocytes; Benzodiazepinones; Cells, Cultured; Clonazepam; Diazepam; Flunitrazepam; Kinetics; Mice; Neurons; Receptors, GABA-A; Temperature | 1984 |
Autoradiographic localization of benzodiazepine receptors in the rat kidney.
Topics: Animals; Autoradiography; Benzodiazepinones; Clonazepam; Diazepam; Flunitrazepam; Kidney; Kidney Tubules, Distal; Loop of Henle; Male; Mucoproteins; Rats; Rats, Inbred Strains; Receptors, GABA-A; Tritium; Uromodulin | 1984 |
A study on benzodiazepine receptor binding in audiogenic seizure-susceptible rats.
Topics: Acoustic Stimulation; Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Convulsants; Diazepam; Female; Flunitrazepam; In Vitro Techniques; Male; Muscimol; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1984 |
Benzodiazepine binding sites in human myometrium.
Topics: Adult; Benzodiazepinones; Binding Sites; Cell Membrane; Clonazepam; Diazepam; Female; Flunitrazepam; Humans; In Vitro Techniques; Lorazepam; Middle Aged; Myometrium; Receptors, GABA-A | 1984 |
Analysis of benzodiazepine binding sites in rat pituitary gland.
Topics: Animals; Benzodiazepinones; Binding, Competitive; Clonazepam; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Pituitary Gland; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1984 |
Benzodiazepine binding sites in human pineal gland.
Topics: Adolescent; Adult; Aged; Animals; Benzodiazepinones; Binding, Competitive; Cerebral Cortex; Child; Child, Preschool; Clonazepam; Diazepam; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Humans; In Vitro Techniques; Infant; Kinetics; Male; Middle Aged; Pineal Gland; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1984 |
Decreased convulsant potency of picrotoxin and pentetrazol and enhanced [3H]flunitrazepam cortical binding following stressful manipulations in rats.
Topics: Animals; Anti-Anxiety Agents; Cerebral Cortex; Diazepam; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Isoniazid; Male; Muscimol; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Stress, Physiological; Thiosemicarbazones | 1980 |
Audiogenic seizures: increased benzodiazepin receptor binding in a susceptible strain of mice.
Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Binding Sites; Brain; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Mice; Receptors, Drug; Seizures; Species Specificity | 1980 |
Venous complications after intravenous injection of diazepam, flunitrazepam, thiopentone and etomidate.
Topics: Adult; Anesthesia, Intravenous; Anti-Anxiety Agents; Diazepam; Double-Blind Method; Etomidate; Female; Flunitrazepam; Humans; Imidazoles; Injections, Intravenous; Male; Middle Aged; Phlebitis; Random Allocation; Thiopental; Thrombophlebitis | 1980 |
[Clinical pharmacokinetics of midazolam, flunitrazepam and diazepam (author's transl)].
Topics: Anti-Anxiety Agents; Benzodiazepines; Biotransformation; Diazepam; Dose-Response Relationship, Drug; Flunitrazepam; Humans; Metabolic Clearance Rate; Midazolam; Protein Binding; Tissue Distribution | 1981 |
Benzodiazepine binding and interactions with the GABA receptor complex in living cultures of rat cerebral cortex.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Binding, Competitive; Cells, Cultured; Cerebral Cortex; Chlorides; Diazepam; Fetus; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Membrane Potentials; Neurons; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1981 |
The effect of chronic diazepam treatment on discrimination performance and 3H-flunitrazepam binding in the brains of shocked and nonshocked rats.
Topics: Animals; Anti-Anxiety Agents; Brain; Diazepam; Discrimination, Psychological; Electroshock; Flunitrazepam; Male; Membranes; Rats | 1981 |
Effect of estazolam on the caudate spindle in the cat.
Topics: Animals; Anti-Anxiety Agents; Cats; Caudate Nucleus; Clonazepam; Diazepam; Electroencephalography; Estazolam; Female; Flunitrazepam; Male | 1981 |
[Comparative pharmacokinetics of diazepam and flunitrazepam].
Topics: Anti-Anxiety Agents; Biological Availability; Diazepam; Flunitrazepam; Half-Life; Humans; Kinetics; Liver | 1981 |
[Pharmacoclinical competition between the benzodiazepines. Demonstration with diazepam and flunitrazepam in man].
Topics: Adolescent; Adult; Aged; Anesthesia, Intravenous; Anti-Anxiety Agents; Binding, Competitive; Child; Child, Preschool; Diazepam; Flunitrazepam; Humans; Infant; Middle Aged | 1981 |
Determination of biological activity of alprazolam, triazolam and their metabolites.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Benzodiazepines; Binding, Competitive; Brain; Diazepam; Flunitrazepam; Kinetics; Male; Membranes; Rats; Rats, Inbred Strains; Receptors, Drug; Receptors, GABA-A; Triazolam | 1982 |
[Pharmacokinetics and metabolism - tranquilizing agents (minor and major), benzodiazepine].
Topics: Anti-Anxiety Agents; Antipsychotic Agents; Chemical Phenomena; Chemistry; Diazepam; Droperidol; Flunitrazepam; Humans; Injections, Intramuscular; Injections, Intravenous; Kinetics | 1981 |
Benzodiazepine receptor number after acute administration of alprazolam and diazepam.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Benzodiazepines; Binding, Competitive; Brain; Diazepam; Flunitrazepam; In Vitro Techniques; Kinetics; Male; Membranes; Rats; Rats, Inbred Strains; Receptors, Drug; Receptors, GABA-A | 1982 |
Benzodiazepines and gamma-aminobutyric acid.
Topics: Animals; Anti-Anxiety Agents; Binding, Competitive; Diazepam; Evoked Potentials; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Neural Inhibition; Raphe Nuclei; Receptors, Drug; Receptors, GABA-A; Synaptic Transmission | 1982 |
Flunitrazepam increases and diazepam decreases the lower oesophageal sphincter tone when administered intravenously.
Topics: Adult; Anti-Anxiety Agents; Diazepam; Esophagogastric Junction; Female; Flunitrazepam; Gastroesophageal Reflux; Humans; Injections, Intravenous; Male; Manometry; Middle Aged | 1982 |
The effect of temperature on CL 218872 and propyl beta-carboline-3-carboxylate inhibition of [3H]-flunitrazepam binding in rat brain.
Topics: Animals; Anti-Anxiety Agents; Binding Sites; Carbolines; Cerebral Cortex; Diazepam; Flunitrazepam; Hippocampus; Indoles; Kinetics; Male; Pyridazines; Rats; Rats, Inbred Strains | 1982 |
Flunitrazepam versus diazepam for endoscopies.
Topics: Anti-Anxiety Agents; Diazepam; Endoscopy; Flunitrazepam; Humans | 1982 |
[Effect of flunitrazepam and diazepam on cerebrospinal fluid pressure (author's transl)].
Topics: Adolescent; Adult; Anti-Anxiety Agents; Cerebrospinal Fluid; Diazepam; Female; Flunitrazepam; Humans; Intracranial Pressure; Male; Middle Aged | 1982 |
Quantitative receptor autoradiography using [3H]ultrofilm: application to multiple benzodiazepine receptors.
Topics: Animals; Anti-Anxiety Agents; Autoradiography; Azoles; Binding, Competitive; Brain; Diazepam; Flunitrazepam; Pyridazines; Quinuclidinyl Benzilate; Rats; Receptors, Drug; Receptors, GABA-A; Receptors, Muscarinic; Tritium | 1982 |
Tofizopam modulates the affinity of benzodiazepine receptors in the rat brain.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Brain; Diazepam; Flunitrazepam; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Drug; Receptors, GABA-A; Receptors, Neurotransmitter | 1982 |
Comparison of the kinetics of [3H]diazepam and [3H]flunitrazepam binding to cortical synaptosomal membranes.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Cerebral Cortex; Diazepam; Filtration; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Male; Pentobarbital; Rats; Rats, Inbred Strains; Sodium Chloride; Synaptic Membranes | 1982 |
Flunitrazepam protects mice against lidocaine and bupivacaine-induced convulsions.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Bupivacaine; Diazepam; Dose-Response Relationship, Drug; Female; Flunitrazepam; Lidocaine; Mice; Seizures | 1983 |
[Comparison of flunitrazepam and diazepam for sedation during local anesthesia in gastroscopy].
Topics: Anesthesia, Local; Anti-Anxiety Agents; Diazepam; Flunitrazepam; Gastroscopy; Humans; Injections, Intravenous; Preanesthetic Medication | 1982 |
Effects of some benzodiazepines on the acetylcholine release in the anterior horn of the lateral cerebral ventricle of the cat.
Topics: Acetylcholine; Animals; Anti-Anxiety Agents; Benzodiazepinones; Cats; Cerebral Ventricles; Clonazepam; Diazepam; Flunitrazepam; Male | 1982 |
The use of short- and long-acting hypnotics in clinical medicine.
Topics: Anti-Anxiety Agents; Diazepam; Flunitrazepam; Humans; Hypnotics and Sedatives; Psychomotor Performance; Sleep; Sleep Initiation and Maintenance Disorders; Substance Withdrawal Syndrome | 1981 |
A comparison of flunitrazepam and diazepam in the prevention of local anesthetic-induced convulsions.
Topics: Animals; Anti-Anxiety Agents; Bupivacaine; Diazepam; Female; Flunitrazepam; Lidocaine; Mice; Seizures | 1983 |
Effects of new benzodiazepine estazolam on ECOG pattern and maximal electroshock (MES) in the rat.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Diazepam; Electroshock; Estazolam; Flunitrazepam; Male; Rats; Rats, Inbred Strains; Seizures; Time Factors | 1983 |
Interaction of triazolobenzodiazepines with benzodiazepine receptors.
Topics: Animals; Benzodiazepines; Binding, Competitive; Diazepam; Flunitrazepam; In Vitro Techniques; Male; Membranes; Mice; Receptors, Cell Surface; Receptors, GABA-A; Time Factors | 1983 |
The effect of five drugs in coma doses on neurotransmitter amino acids in the brains of guinea pigs.
Topics: Amino Acids; Animals; Brain; Brain Chemistry; Central Nervous System Agents; Central Nervous System Depressants; Diazepam; Flunitrazepam; Guinea Pigs; Neurotransmitter Agents; Phenobarbital; Phenytoin; Pregnanediones | 1983 |
In vitro effect of benzodiazepines on polymorphonuclear leukocyte oxidative activity.
Topics: Anti-Anxiety Agents; Clorazepate Dipotassium; Diazepam; Flunitrazepam; Humans; In Vitro Techniques; Lymphocyte Activation; Neutrophils; Nitroblue Tetrazolium; Oxygen Consumption; Stimulation, Chemical; Zymosan | 1984 |
Benzodiazepine receptor ligands with opposing pharmacologic actions.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Diazepam; Flumazenil; Flunitrazepam; Kinetics; Ligands; Membranes; Models, Psychological; Pyrazoles; Rats; Receptors, Cell Surface; Receptors, GABA-A; Temperature | 1983 |
[Comparative clinical toxicology of 5 benzodiazepine derivatives].
Topics: Adult; Anti-Anxiety Agents; Bromazepam; Child; Coma; Diazepam; Dose-Response Relationship, Drug; Female; Flunitrazepam; Humans; Lorazepam; Male; Metabolic Clearance Rate; Oxazepam; Prognosis; Respiratory Insufficiency; Suicide, Attempted | 1984 |
The quinolines PK 8165 and PK 9084 possess benzodiazepine-like activity in vitro but not in vivo.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Brain; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Mice; Quinolines; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1984 |
The benzodiazepine receptor ligand CL218,872 has both anxiolytic and sedative properties in rodents.
Topics: Aggression; Animals; Anti-Anxiety Agents; Arousal; Brain; Diazepam; Dose-Response Relationship, Drug; Flunitrazepam; Humans; Male; Mice; Mice, Inbred Strains; Motor Activity; Motor Skills; Pyridazines; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1984 |
Increased number of brain benzodiazepine receptors after in-vivo administration of estazolam to rats.
Topics: Animals; Anti-Anxiety Agents; Binding Sites; Brain; Cerebellum; Diazepam; Estazolam; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Kinetics; Male; Rats; Receptors, GABA-A | 1984 |
Urinary and brain beta-carboline-3-carboxylates as potent inhibitors of brain benzodiazepine receptors.
Topics: Binding, Competitive; Brain; Carbolines; Diazepam; Flunitrazepam; Humans; Indoles; Ligands; Receptors, Drug; Receptors, GABA-A; Receptors, Neurotransmitter; Structure-Activity Relationship; Synaptic Membranes | 1980 |
Benzodiazepine receptor: localization by photoaffinity labeling and isolation of a possible endogenous ligand.
Topics: Affinity Labels; Animals; Autoradiography; Benzodiazepines; Cerebral Cortex; Diazepam; Flunitrazepam; Ligands; Niacinamide; Photochemistry; Rats; Receptors, Drug; Receptors, GABA-A; Receptors, Neurotransmitter; Synaptosomes | 1980 |
[3H]propyl beta-carboline-3-carboxylate binds specifically to brain benzodiazepine receptors.
Topics: Animals; Brain; Carbolines; Cell Fractionation; Cell Membrane; Cerebellum; Diazepam; Flunitrazepam; Frontal Lobe; Hippocampus; In Vitro Techniques; Indoles; Rats; Receptors, Drug; Receptors, GABA-A | 1981 |
Increase of benzodiazepine binding to the membranes isolated in the presence of diazepam.
Topics: Animals; Benzodiazepines; Brain Chemistry; Cell Membrane; Diazepam; Flunitrazepam; Male; Rats; Receptors, Drug; Receptors, GABA-A | 1981 |
Benzodiazepine receptors on primary cultures of mouse astrocytes.
Topics: Animals; Anticonvulsants; Astrocytes; Binding, Competitive; Cell Membrane; Cells, Cultured; Diazepam; Flunitrazepam; Mice; Phenobarbital; Receptors, Drug; Receptors, GABA-A | 1981 |
Characterization of photoaffinity labeling of benzodiazepine binding sites.
Topics: Affinity Labels; Animals; Benzodiazepines; Brain; Cell Line; Cell Membrane; Cerebral Cortex; Corpus Striatum; Diazepam; Flunitrazepam; Glioma; Hippocampus; Kidney; Kinetics; Rats; Rats, Inbred Strains; Receptors, Drug; Receptors, GABA-A | 1981 |
Benzodiazepine antagonist Ro 15-1788: binding characteristics and interaction with drug-induced changes in dopamine turnover and cerebellar cGMP levels.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Brain; Cerebellum; Cerebral Cortex; Cyclic GMP; Diazepam; Dopamine; Flumazenil; Flunitrazepam; Kinetics; Mice; Receptors, Drug; Receptors, GABA-A | 1981 |
Involvement of tyrosyl residues in the binding of benzodiazepines to their brain receptors.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Brain; Cattle; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; Imidazoles; Nitrazepam; Receptors, Drug; Receptors, GABA-A; Receptors, Neurotransmitter; Tetranitromethane; Tyrosine | 1981 |
Binding of [3H]ethyl-beta-carboline-3-carboxylate to brain benzodiazepine receptors: effect of drugs and anions.
Topics: Animals; Barbiturates; Benzodiazepines; Brain; Carbolines; Cerebellum; Cerebral Cortex; Diazepam; Flunitrazepam; Indoles; Male; Pyrazoles; Pyridines; Rats; Rats, Inbred Strains; Receptors, Drug; Receptors, GABA-A; Sodium Chloride | 1981 |
beta-Carboline inhibition of benzodiazepine receptor binding in vivo.
Topics: Animals; Binding, Competitive; Carbolines; Clonazepam; Diazepam; Flunitrazepam; Indoles; Male; Muridae; Receptors, Drug; Receptors, GABA-A | 1982 |
Presence of two benzodiazepine binding sites in the rat hippocampus.
Topics: Animals; Cerebellum; Cerebral Cortex; Diazepam; Flunitrazepam; Hippocampus; Male; Rats; Receptors, Drug; Receptors, GABA-A | 1982 |
Temperature dependence of the benzodiazepine-receptor interaction.
Topics: Animals; Brain; Diazepam; Flunitrazepam; In Vitro Techniques; Kinetics; Membranes; Rats; Receptors, Drug; Receptors, GABA-A; Temperature; Thermodynamics | 1982 |
Does the reversal of the anticonflict effect of phenobarbital by beta-CCE and FG 7142 indicate benzodiazepine receptor-mediated anxiogenic properties?
Topics: Animals; Anxiety; Carbolines; Conflict, Psychological; Diazepam; Flunitrazepam; Humans; Indoles; Male; Phenobarbital; Punishment; Rats; Rats, Inbred Strains; Receptors, Drug; Receptors, GABA-A | 1982 |
Effects of agents which enhance GABA-mediated neurotransmission on licking conflict in rats and exploration in mice.
Topics: Animals; Conflict, Psychological; Diazepam; Exploratory Behavior; Flunitrazepam; gamma-Aminobutyric Acid; Male; Mice; Muscimol; Nitrazepam; Rats; Rats, Inbred Strains; Synaptic Transmission; Urethane; Valproic Acid | 1982 |
Halopemide and benzodiazepine binding sites.
Topics: Animals; Brain; Diazepam; Domperidone; Flunitrazepam; In Vitro Techniques; Male; Models, Biological; Rats; Rats, Inbred Strains; Receptors, Drug; Receptors, GABA-A | 1982 |
Regional heterogeneity of benzodiazepine binding sites in rat brain.
Topics: Animals; Binding, Competitive; Brain; Carbolines; Cerebellum; Chlorides; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Kinetics; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1982 |
Photoaffinity labelling of the benzodiazepine receptor cannot be used to predict ligand efficacy.
Topics: Animals; Binding, Competitive; Carbolines; Diazepam; Flunitrazepam; Ligands; Methods; Pyrazoles; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
PK 8165 and PK 9084, two quinoline derivatives with anxiolytic properties, antagonize the anticonvulsant effects of diazepam.
Topics: Animals; Anticonvulsants; Benzodiazepines; Bicuculline; Brain; Diazepam; Drug Antagonism; Flunitrazepam; gamma-Aminobutyric Acid; Male; Mice; Quinolines; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1983 |
Development and differentiation of the benzodiazepine receptor in cultures of fetal mouse spinal cord.
Topics: Animals; Benzodiazepinones; Cell Differentiation; Clonazepam; Diazepam; Fetus; Flunitrazepam; Kinetics; Mice; Neurons; Receptors, Cell Surface; Receptors, GABA-A; Spinal Cord | 1983 |
Group-selective reagent modification of the benzodiazepine-gamma-aminobutyric acid receptor-ionophore complex reveals that low-affinity gamma-aminobutyric acid receptors stimulate benzodiazepine binding.
Topics: Animals; Benzodiazepines; Cell Membrane; Cerebellum; Cerebral Cortex; Diazepam; Diazonium Compounds; Diethyl Pyrocarbonate; Flunitrazepam; Hippocampus; Male; Muscimol; Pentobarbital; Rats; Receptors, Cell Surface; Receptors, GABA-A; Sulfanilic Acids | 1983 |
The benzodiazepine/GABA receptor complex during severe ethanol intoxication and withdrawal in the rat.
Topics: Alcoholic Intoxication; Alcoholism; Animals; Diazepam; Ethanol; Flunitrazepam; Humans; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Substance Withdrawal Syndrome; Tritium | 1982 |
Benzodiazepine receptor declines in hippocampal formation following limbic seizures.
Topics: Afferent Pathways; Animals; Diazepam; Dominance, Cerebral; Flunitrazepam; Hippocampus; Limbic System; Male; Phenobarbital; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1983 |
Benzodiazepine receptor binding by membranes from brain cell cultures following chronic treatment with diazepam.
Topics: Animals; Benzodiazepines; Brain; Cells, Cultured; Diazepam; Embryo, Mammalian; Flunitrazepam; Kinetics; Mice; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Characterization of the binding of [3H]Ro 5-4864, a convulsant benzodiazepine, to guinea pig brain.
Topics: Animals; Benzodiazepinones; Binding Sites; Brain; Cats; Convulsants; Diazepam; Flunitrazepam; Guinea Pigs; Kinetics; Male; Mice; Rats; Receptors, Cell Surface; Receptors, GABA-A; Species Specificity; Tissue Distribution | 1984 |
Brain receptors and zopiclone.
Topics: Animals; Azabicyclo Compounds; Binding, Competitive; Brain; Cerebellum; Chlordiazepoxide; Diazepam; Flunitrazepam; Hippocampus; Hypnotics and Sedatives; In Vitro Techniques; Male; Mice; Nitrazepam; Piperazines; Rats; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A | 1983 |
Benzodiazepines receptor binding in vivo: pharmacokinetic and pharmacological significance.
Topics: Adrenal Glands; Animals; Benzodiazepinones; Brain; Carbolines; Corticosterone; Diazepam; Flumazenil; Flunitrazepam; Kinetics; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Inhibition of benzodiazepine and GABA receptor binding by amino-gamma-carbolines and other amino acid pyrolysate mutagens.
Topics: Animals; Binding, Competitive; Carbolines; Chlorides; Diazepam; Flunitrazepam; Harmine; Indoles; Ion Channels; Kinetics; Male; Mice; Mice, Inbred Strains; Muscimol; Mutagens; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1984 |
Changes in benzodiazepine receptors by acute stress: different effect of chronic diazepam or RO 15-1788 treatment.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Cerebral Cortex; Diazepam; Female; Flumazenil; Flunitrazepam; Hippocampus; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Neurotransmitter; Stress, Physiological | 1983 |
Photoaffinity labelling of the benzodiazepine receptor compromises the recognition site but not its effector mechanism.
Topics: Affinity Labels; Animals; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Photochemistry; Rats; Receptors, Cell Surface; Receptors, GABA-A; Sodium Chloride; Ultraviolet Rays | 1984 |
Micromolar-affinity benzodiazepine receptors regulate voltage-sensitive calcium channels in nerve terminal preparations.
Topics: Animals; Benzodiazepines; Brain; Calcium; Cations, Divalent; Clonazepam; Diazepam; Female; Flunitrazepam; Ion Channels; Kinetics; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Synaptosomes | 1984 |
Computer-assisted determination of benzodiazepine receptor heterogeneity.
Topics: Animals; Binding, Competitive; Brain Chemistry; Carbolines; Computers; Diazepam; Flunitrazepam; In Vitro Techniques; Male; Models, Biological; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1984 |
Brain receptors and zopiclone.
Topics: Animals; Azabicyclo Compounds; Barbiturates; Binding, Competitive; Brain; Chlordiazepoxide; Cyclic GMP; Diazepam; Flunitrazepam; Hippocampus; Hypnotics and Sedatives; In Vitro Techniques; Male; Piperazines; Rats; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A | 1982 |
[Comparison of the effects of flunitrazepam and diazepam used in premedication].
Topics: Adult; Aged; Amnesia; Anesthesia; Anxiety; Diazepam; Drug Tolerance; Female; Flunitrazepam; Hemodynamics; Humans; Hypnotics and Sedatives; Male; Middle Aged; Preanesthetic Medication; Resuscitation | 1984 |
Brain serotonin receptors as a target for the putative anxiolytic TVX Q 7821.
Topics: Aggression; Analgesia; Animals; Avoidance Learning; Brain; Diazepam; Electroshock; Flunitrazepam; Humans; Male; Mice; Mice, Inbred Strains; Pyrimidines; Receptors, Serotonin; Serotonin | 1984 |
A new method for the evaluation of benzodiazepines based on their ability to block muscimol-induced myoclonic jerks in mice.
Topics: Animals; Benzodiazepines; Diazepam; Drug Evaluation; Flunitrazepam; Male; Mice; Muscimol; Myoclonus; Oxazoles; Spinal Cord | 1981 |
[The use of tramadol-HCl (Tramal) as adjuvant in regional anaesthesia. Clinical report (author's transl)].
Topics: Anesthesia, Conduction; Cyclohexanols; Diazepam; Droperidol; Flunitrazepam; Humans; Pentazocine; Pirinitramide; Tramadol; Triflupromazine | 1982 |
Diazepam effects on striatal met-enkephalin levels following long-term pharmacological manipulations.
Topics: Animals; Corpus Striatum; Diazepam; Endorphins; Enkephalin, Methionine; Enkephalins; Flunitrazepam; Male; Rats | 1980 |
[Does a rebound insomnia following benzodiazepine administration exist?].
Topics: Benzodiazepines; Diazepam; Flunitrazepam; Flurazepam; Humans; Nitrazepam; Sleep Initiation and Maintenance Disorders; Substance Withdrawal Syndrome; Triazolam | 1980 |
Comparison of benzodiazepine receptor ligands with partial agonistic, antagonistic or partial inverse agonistic properties in precipitating withdrawal in squirrel monkeys.
Topics: Animals; Diazepam; Drug Interactions; Drug Tolerance; Female; Flunitrazepam; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Ligands; Male; Saimiri; Sleep; Substance Withdrawal Syndrome | 1995 |
Flunitrazepam and nordiazepam slowly released from silastic capsules induce physical dependence in rat.
Topics: Animals; Anti-Anxiety Agents; Antidotes; Biological Availability; Delayed-Action Preparations; Diazepam; Drug Implants; Female; Flumazenil; Flunitrazepam; Nordazepam; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Substance-Related Disorders | 1995 |
Benzodiazepine binding sites in alcoholic cirrhotics: evidence for gender differences.
Topics: Adult; Aged; Autopsy; Diazepam; Female; Flunitrazepam; Humans; Liver Cirrhosis, Alcoholic; Male; Middle Aged; Receptors, GABA-A; Sex Factors | 1995 |
Precipitated withdrawal in squirrel monkeys after repeated daily oral administration of alprazolam, diazepam, flunitrazepam or oxazepam.
Topics: Administration, Oral; Alprazolam; Animals; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Drug Tolerance; Female; Flumazenil; Flunitrazepam; Male; Muscle Relaxation; Oxazepam; Saimiri; Sleep; Substance Withdrawal Syndrome; Substance-Related Disorders; Tremor | 1995 |
[Midazolam for premedication in children].
Topics: Administration, Intranasal; Administration, Oral; Administration, Rectal; Anesthetics; Child; Child, Preschool; Diazepam; Flunitrazepam; Humans; Infant; Injections, Intramuscular; Injections, Intravenous; Ketamine; Midazolam; Preanesthetic Medication | 1995 |
Allosteric modulation of the GABA-induced chloride current in frog melanotrophs.
Topics: Action Potentials; Allosteric Regulation; Animals; Anti-Anxiety Agents; Azepines; Benzodiazepinones; Chloride Channels; Convulsants; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; Ion Channels; Melanocyte-Stimulating Hormones; Membrane Proteins; Pituitary Gland; Ranidae; Receptors, GABA-A | 1993 |
Immunohistochemical and neurochemical evidence for GABAA receptor heterogeneity between the hypothalamus and cortex.
Topics: Animals; Cerebral Cortex; Chlorides; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; Hypothalamus; Male; Rats; Receptors, GABA-A | 1994 |
A system for testing the development and reversal of anticonvulsant tolerance to benzodiazepines in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Carbolines; Diazepam; Drug Tolerance; Flumazenil; Flunitrazepam; Infusion Pumps, Implantable; Infusions, Parenteral; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Seizures; Solvents; Time Factors | 1993 |
Pharmacological profile of the novel putative anxiolytic agent 1-amino-5-bromouracil.
Topics: Anesthetics; Animals; Anti-Anxiety Agents; Bromouracil; Conflict, Psychological; Diazepam; Drug Synergism; Flunitrazepam; Male; Mice; Mice, Inbred ICR; Motor Activity; Muscle Relaxants, Central; Postural Balance; Rats; Rats, Wistar; Receptors, GABA-A | 1994 |
Allosteric modulation of [35S]TBPS-binding in the cerebral cortex of the rat during postnatal development.
Topics: Aging; Allosteric Regulation; Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chloride Channels; Convulsants; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Stereoisomerism; Sulfur Radioisotopes | 1994 |
Effects of intravenous anaesthetics on function and metabolism in the isolated rat heart-lung preparation.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Anesthesia, Intravenous; Animals; Atrial Function, Right; Blood Pressure; Cardiac Output; Diazepam; Flunitrazepam; Heart; Heart Rate; Ketamine; Lung; Male; Midazolam; Myocardium; Rats; Rats, Wistar; Ventricular Function, Left; Ventricular Pressure | 1994 |
[Effect of sedation on otoacoustic emissions].
Topics: Acoustic Stimulation; Adolescent; Adult; Child; Conscious Sedation; Diazepam; Female; Flunitrazepam; Humans; Male; Middle Aged; Otoacoustic Emissions, Spontaneous; Pitch Perception; Reaction Time | 1994 |
Regional changes in [3H]zolpidem binding to brain benzodiazepine receptors in flurazepam tolerant rat: comparison with changes in [3H]flunitrazepam binding.
Topics: Animals; Brain; Diazepam; Drug Tolerance; Flunitrazepam; Flurazepam; Male; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Tritium; Zolpidem | 1994 |
Characterization of the influence of unsaturated free fatty acids on brain GABA/benzodiazepine receptor binding in vitro.
Topics: Animals; Anura; Birds; Brain; Cell Membrane; Cerebral Cortex; Chloride Channels; Diazepam; Fatty Acids, Nonesterified; Fishes; Flunitrazepam; Male; Muscimol; Oleic Acid; Oleic Acids; Phylogeny; Rats; Rats, Wistar; Receptors, GABA; Tritium | 1994 |
Characterization of peripheral benzodiazepine receptors in rat prostatic adenocarcinoma.
Topics: Adenocarcinoma; Animals; Benzodiazepinones; Binding, Competitive; Diazepam; Flunitrazepam; Isoquinolines; Male; Mesoporphyrins; Microsomes; Mitochondria; Neoplasm Transplantation; Prostatic Neoplasms; Rats; Receptors, GABA-A | 1994 |
Anticonvulsant doses of 2-chloro-N6-cyclopentyladenosine, an adenosine A1 receptor agonist, reduce GABAergic transmission in different areas of the mouse brain.
Topics: Adenosine; Animals; Anticonvulsants; Behavior, Animal; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Convulsants; Depression, Chemical; Diazepam; Dose-Response Relationship, Drug; Flunitrazepam; gamma-Aminobutyric Acid; Isoniazid; Male; Mice; Mice, Inbred Strains; Purinergic P1 Receptor Antagonists; Receptors, GABA; Receptors, Purinergic P1; Seizures; Sulfur Radioisotopes; Synaptic Transmission; Tritium; Xanthines | 1993 |
Bicuculline-produced regional differences in the modulation of 35S-TBPS binding by GABA, pentobarbital and diazepam in mouse cerebellum and cortex.
Topics: Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Phenobarbital; Receptors, GABA-A | 1993 |
Effects of intravenous anesthetics on function and metabolism in the reperfused working rat heart.
Topics: Anesthetics; Animals; Diazepam; Flunitrazepam; Heart; Hemodynamics; Injections, Intravenous; Ketamine; Male; Oxygen Consumption; Rats; Rats, Wistar; Time Factors | 1995 |
Changes in benzodiazepine-GABA receptor coupling in an accumbens-habenula circuit after chronic diazepam treatment.
Topics: Animals; Anti-Anxiety Agents; Autoradiography; Binding, Competitive; Diazepam; Drug Implants; Flunitrazepam; GABA Antagonists; GABA-A Receptor Antagonists; Injections, Intraperitoneal; Male; Maze Learning; Nucleus Accumbens; Pyridazines; Rats; Receptors, GABA-A; Thalamus | 1995 |
Biochemical evaluations of the effects of loreclezole and propofol on the GABAA receptor in rat brain.
Topics: Anesthetics; Animals; Anticonvulsants; Brain; Bridged Bicyclo Compounds, Heterocyclic; Diazepam; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Hypnotics and Sedatives; In Vitro Techniques; Male; Muscimol; Pentobarbital; Pregnanediones; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sulfur Radioisotopes; Triazoles; Tritium | 1996 |
Differences in benzodiazepine binding in quail selectively bred for differences in tonic immobility.
Topics: Animals; Anti-Anxiety Agents; Azides; Benzodiazepines; Brain; Chlorine; Coturnix; Diazepam; Ethanol; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Motor Activity; Radioisotopes; Receptors, GABA-A | 1996 |
Estimation of the binding affinity constants of soluble ligand-receptor complexes by a rapid filtration technique: [3H]-flunitrazepam-bovine serum albumin as an example.
Topics: Binding Sites; Blood Proteins; Diazepam; Filtration; Flunitrazepam; GABA Modulators; Ligands; Protein Binding; Receptors, Cell Surface; Serum Albumin, Bovine | 1996 |
Reciprocal effects of chronic diazepam and melatonin on brain melatonin and benzodiazepine binding sites.
Topics: Animals; Body Weight; Brain; Cerebral Cortex; Diazepam; Flumazenil; Flunitrazepam; Kinetics; Male; Medulla Oblongata; Melatonin; Pons; Rats; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, GABA-A; Receptors, Melatonin | 1996 |
The neurochemical pathology of thiamine deficiency: GABAA and glutamateNMDA receptor binding sites in a goat model.
Topics: Alcoholism; Amprolium; Animals; Brain Chemistry; Diazepam; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Goats; In Vitro Techniques; Male; Muscimol; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes; Synaptosomes; Thiamine Deficiency | 1996 |
Diazepam physical dependence and withdrawal in rats is associated with alteration in GABAA receptor function.
Topics: Animals; Benzodiazepines; Cerebral Cortex; Chloride Channels; Chlorides; Diazepam; Flumazenil; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred F344; Receptors, GABA-A; Substance Withdrawal Syndrome; Substance-Related Disorders | 1996 |
Receptor binding sites and uptake activities mediating GABA neurotransmission in chronic alcoholics with Wernicke encephalopathy.
Topics: Adult; Aged; Aged, 80 and over; Alcoholism; Binding Sites; Diazepam; Female; Fibrosis; Flunitrazepam; Frontal Lobe; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Motor Cortex; Muscimol; Receptors, GABA; Synaptic Transmission; Wernicke Encephalopathy | 1996 |
GABAA receptors in damaged cerebral cortex areas in human chronic alcoholics.
Topics: Adult; Aged; Alcoholism; Binding Sites; Case-Control Studies; Cerebral Cortex; Diazepam; Flunitrazepam; Humans; In Vitro Techniques; Kinetics; Liver Cirrhosis, Alcoholic; Middle Aged; Muscimol; Receptors, GABA-A; Wernicke Encephalopathy | 1994 |
Intravenous anaesthesia and leukocytes.
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Anti-Anxiety Agents; Diazepam; Flunitrazepam; Humans; Hypnotics and Sedatives; Neutrophils; Pharmaceutic Aids | 1997 |
Diazepam-insensitive GABAA receptors on postnatal spiral ganglion neurones in culture.
Topics: Animals; Animals, Newborn; Baclofen; Bicuculline; Carbolines; Cells, Cultured; Convulsants; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pentobarbital; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA-A; Spiral Ganglion; Zinc | 1997 |
Significant inhibition of spontaneous IgA secretion by selective peripheral-type benzodiazepine receptor ligands.
Topics: Anti-Anxiety Agents; Antibody-Producing Cells; B-Lymphocytes; Clonazepam; Diazepam; Flunitrazepam; GABA-A Receptor Antagonists; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Isoquinolines; Lymphocyte Activation | 1997 |
Acyl-CoA binding protein (ACBP) regulates acyl-CoA:cholesterol acyltransferase (ACAT) in human mononuclear phagocytes.
Topics: Acyl Coenzyme A; Animals; Binding, Competitive; Blotting, Northern; Carrier Proteins; Cattle; Cholesterol; Diazepam; Diazepam Binding Inhibitor; Endoplasmic Reticulum, Rough; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Flunitrazepam; Gene Expression Regulation; Humans; Macrophages; Microsomes; Monocytes; Myelin P2 Protein; Neoplasm Proteins; Protein Binding; RNA, Messenger; Sterol O-Acyltransferase; Tumor Suppressor Proteins | 1997 |
In vivo administration of the 5-HT1A receptor agonist 8-OH-DPAT interferes with brain GABA(A)/benzodiazepine receptor complexes.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cerebral Cortex; Chlorides; Diazepam; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; Male; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Synaptosomes | 1997 |
Diazepam protects against rat hippocampal neuronal cell death induced by antisense oligodeoxynucleotide to GABA(A) receptor gamma2 subunit.
Topics: Animals; Cell Death; Diazepam; Flunitrazepam; GABA Modulators; Hippocampus; Male; Muscarinic Antagonists; Nerve Degeneration; Oligonucleotides, Antisense; Quinuclidinyl Benzilate; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Muscarinic; Time Factors | 1997 |
Direct resolution, characterization, and stereospecific binding properties of an atropisomeric 1,4-benzodiazepine.
Topics: Benzodiazepines; Binding Sites; Binding, Competitive; Cell Membrane; Circular Dichroism; Diazepam; Flunitrazepam; Humans; Models, Molecular; Molecular Conformation; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Receptors, GABA-A; Serum Albumin; Stereoisomerism | 1997 |
Diazepam enhancement of GABA-gated currents in binary and ternary GABAA receptors: relationship to benzodiazepine binding site density.
Topics: Animals; Benzodiazepines; Binding Sites; Cell Line; Chloride Channels; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Kidney; Membrane Potentials; Radioligand Assay; Rats; Receptors, GABA-A | 1997 |
The effect of chronic benzodiazepines exposure on body weight in rats.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Body Weight; Diazepam; Dose-Response Relationship, Drug; Female; Flumazenil; Flunitrazepam; GABA Modulators; Male; Nordazepam; Oxazepam; Rats; Rats, Sprague-Dawley; Sex Factors; Time Factors; Weight Gain | 1998 |
Regulation of GABA(A) receptor alpha1 protein is a sensitive indicator of benzodiazepine agonist efficacy.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Cells, Cultured; Cerebellum; Diazepam; Flunitrazepam; GABA Modulators; Pyrrolidines; Quinolizines; Rats; Receptors, GABA-A | 1998 |
Determination of benzodiazepines in human urine and plasma with solvent modified solid phase micro extraction and gas chromatography; rationalisation of method development using experimental design strategies.
Topics: Alprazolam; Anti-Anxiety Agents; Benzodiazepines; Chromatography, Gas; Diazepam; Flunitrazepam; Humans; Hydrogen-Ion Concentration; Models, Chemical; Nordazepam; Oxazepam; Research Design | 1998 |
Molecular and neurochemical evaluation of the effects of etizolam on GABAA receptors under normal and stress conditions.
Topics: Acetylcholine; Animals; Anti-Anxiety Agents; Binding, Competitive; Chlorides; Diazepam; Electrophysiology; Electroshock; Flunitrazepam; GABA Modulators; Hippocampus; Humans; In Vitro Techniques; Ligands; Male; Microdialysis; Oocytes; Patch-Clamp Techniques; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Recombinant Proteins; Stress, Psychological; Xenopus laevis | 1999 |
In vivo and in vitro hyperbaric studies in mice suggest novel sites of action for ethanol.
Topics: Allosteric Regulation; Analysis of Variance; Animals; Diazepam; Ethanol; Flunitrazepam; GABA Modulators; Hyperbaric Oxygenation; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Pentobarbital; Pregnanolone; Receptors, GABA-A | 1999 |
Decreased GABA enhancement of benzodiazepine binding after a single dose of diazepam.
Topics: Animals; Benzodiazepines; Cerebellum; Cerebral Cortex; Diazepam; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Homeostasis; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Time Factors | 1999 |
Fluorescence imaging of GABAA receptor-mediated intracellular [Cl-] in P19-N cells reveals unique pharmacological properties.
Topics: Animals; Central Nervous System Depressants; Chlorides; Diazepam; DNA Primers; Ethanol; Flunitrazepam; Fluorescent Dyes; GABA Agonists; GABA Modulators; Gene Expression; Mice; Muscimol; Neoplastic Stem Cells; Neuroglia; Pentobarbital; Pregnanolone; Quinolinium Compounds; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tritium | 1999 |
Neuropharmacological profile of peripheral benzodiazepine receptor agonists, DAA1097 and DAA1106.
Topics: Acetamides; Anesthesia; Animals; Anti-Anxiety Agents; Benzodiazepinones; Brain; Buspirone; Cell Membrane; Diazepam; Exploratory Behavior; Flunitrazepam; GABA Modulators; GABA-A Receptor Agonists; Hexobarbital; Isoquinolines; Male; Mice; Mice, Inbred ICR; Mitochondria; Motor Activity; Phenyl Ethers | 1999 |
Single- and repeated-dose local toxicity in the nasal cavity of rabbits after intranasal administration of different glycols for formulations containing benzodiazepines.
Topics: Administration, Intranasal; Animals; Anti-Anxiety Agents; Benzodiazepines; Chemistry, Pharmaceutical; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Drug Evaluation; Flunitrazepam; Lorazepam; Nasal Cavity; Pharmaceutic Aids; Polyethylene Glycols; Rabbits; Time Factors | 1999 |
[(3)H]-girisopam, a novel selective benzodiazepine for the 2, 3-benzodiazepine binding site.
Topics: Adult; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Benzodiazepines; Binding Sites; Binding, Competitive; Corpus Striatum; Diazepam; Dopamine; Flunitrazepam; gamma-Aminobutyric Acid; Glutamine; Humans; Male; Organ Specificity; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Serotonin; Structure-Activity Relationship | 1999 |
Peripheral benzodiazepine receptor agonists exhibit potent antiapoptotic activities.
Topics: Apoptosis; Benzodiazepinones; Clonazepam; Diazepam; Flunitrazepam; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Humans; Isoquinolines; Jurkat Cells; Kinetics; Ligands; Receptors, GABA-A; Transfection; Tumor Necrosis Factor-alpha; U937 Cells | 1999 |
6-Chloro-3'-nitroflavone is a potent ligand for the benzodiazepine binding site of the GABA(A) receptor devoid of intrinsic activity.
Topics: Animals; Anticonvulsants; Diazepam; Flavonoids; Flunitrazepam; GABA Modulators; GABA-A Receptor Antagonists; Learning; Male; Mice; Motor Activity; Rats; Rats, Wistar; Receptors, GABA-A; Seizures; Xenopus | 2000 |
Down-regulation of benzodiazepine binding to alpha 5 subunit-containing gamma-aminobutyric Acid(A) receptors in tolerant rat brain indicates particular involvement of the hippocampal CA1 region.
Topics: Alkynes; Animals; Anti-Anxiety Agents; Autoradiography; Benzodiazepines; Binding Sites; Brain; Diazepam; Down-Regulation; Drug Tolerance; Flunitrazepam; Flurazepam; GABA Modulators; Hippocampus; Imidazoles; Kinetics; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Tritium | 2000 |
Evaluation of native GABA(A) receptors containing an alpha 5 subunit.
Topics: Alkynes; Animals; Anti-Anxiety Agents; Anticonvulsants; Autoradiography; Benzodiazepines; Cerebellum; Clobazam; Clonazepam; Diazepam; Flumazenil; Flunitrazepam; GABA-A Receptor Agonists; Hippocampus; Imidazoles; Male; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2001 |
Molecular modeling and QSAR analysis of the interaction of flavone derivatives with the benzodiazepine binding site of the GABA(A) receptor complex.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Binding Sites; Diazepam; Drug Interactions; Flavonoids; Flunitrazepam; Ligands; Models, Molecular; Quantitative Structure-Activity Relationship; Radioligand Assay; Rats; Receptors, GABA-A; Synaptosomes | 2001 |
[3H]Ro 15-1788 binding sites to brain membrane of the saltwater Mugil cephalus.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Carbolines; Cell Membrane; Chlorides; Diazepam; Female; Fishes; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Imidazoles; Ionophores; Male; Pyridines; Receptors, GABA-A; Synaptosomes; Tritium; Zolpidem | 2001 |
Flunitrazepam, a 7-nitro-1,4-benzodiazepine that is unable to bind to the indole-benzodiazepine site of human serum albumin.
Topics: Anti-Anxiety Agents; Autoradiography; Benzodiazepines; Binding Sites; Binding, Competitive; Diazepam; Flunitrazepam; Fluorescent Dyes; Humans; Ligands; Myristic Acid; Orosomucoid; Photoaffinity Labels; Serum Albumin | 2001 |
Activation of GABA(A) receptors in subthalamic neurons in vitro: properties of native receptors and inhibition mechanisms.
Topics: Animals; Bicarbonates; Bicuculline; Chlorides; Diazepam; Electrophysiology; Flunitrazepam; GABA Agonists; GABA Antagonists; GABA Modulators; Membrane Potentials; Muscimol; Neural Inhibition; Neurons; Organ Culture Techniques; Pentobarbital; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA-A; Sesterterpenes; Subthalamic Nucleus | 2001 |
Mechanism of alpha-subunit selectivity of benzodiazepine pharmacology at gamma-aminobutyric acid type A receptors.
Topics: Animals; Anti-Anxiety Agents; Binding, Competitive; Cell Line; Diazepam; Dose-Response Relationship, Drug; Female; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Membrane Potentials; Mutation; Oocytes; Protein Subunits; Pyridazines; Pyridines; Radioligand Assay; Receptors, GABA-A; Tritium; Xenopus laevis; Zolpidem | 2002 |
GABA(A) receptor alpha-1 subunit deletion alters receptor subtype assembly, pharmacological and behavioral responses to benzodiazepines and zolpidem.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Benzodiazepines; Chlorides; Diazepam; Exploratory Behavior; Female; Flunitrazepam; GABA Agonists; GABA Modulators; Gene Deletion; Hypnotics and Sedatives; Male; Mice; Mice, Knockout; Motor Activity; Muscimol; Postural Balance; Pyridines; Radioligand Assay; Receptors, GABA-A; Seizures; Zolpidem | 2002 |
Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy.
Topics: Amino Acid Substitution; Animals; Anti-Anxiety Agents; Cell Line; Diazepam; Epilepsy; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Kinetics; Membrane Potentials; Mutagenesis, Site-Directed; Neurons; Oocytes; Patch-Clamp Techniques; Protein Subunits; Pyridines; Receptors, GABA-A; Recombinant Proteins; Synapses; Synaptic Transmission; Transfection; Xenopus; Zolpidem | 2002 |
GABA(A) receptor sites in the developing human foetus.
Topics: Adult; Aged; Binding Sites; Cell Differentiation; Cerebral Cortex; Diazepam; Female; Fetus; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Infant; Infant, Newborn; Male; Middle Aged; Neural Inhibition; Neurons; Pregnancy; Protein Subunits; Radioligand Assay; Receptors, GABA-A | 2002 |
Quantitative determination of diazepam, nitrazepam and flunitrazepam in tablets using thin-layer chromatography-densitometry technique.
Topics: Chromatography, Thin Layer; Densitometry; Diazepam; Flunitrazepam; Nitrazepam; Tablets | 2003 |
High-dose midazolam and the attenuation of the contractile response to vasoconstrictors in coronary artery segments.
Topics: Animals; Anti-Anxiety Agents; Diazepam; Dose-Response Relationship, Drug; Endothelium, Vascular; Flunitrazepam; Histamine; Hypnotics and Sedatives; In Vitro Techniques; Midazolam; Muscle Contraction; Muscle, Smooth, Vascular; Rats; Serotonin; Vasoconstrictor Agents | 2003 |
Targeted mutation of CCK2 receptor gene modifies the behavioural effects of diazepam in female mice.
Topics: Animals; Anxiety; Cerebellum; Cerebral Cortex; Diazepam; Exploratory Behavior; Female; Flunitrazepam; Gene Targeting; Hippocampus; Injections, Intraperitoneal; Male; Maze Learning; Mice; Mice, Mutant Strains; Motor Activity; Mutation; Radioligand Assay; Receptor, Cholecystokinin B; Receptors, GABA-A; Rotarod Performance Test; Tritium | 2003 |
Screening for drugs of abuse in hair with ion spray LC-MS-MS.
Topics: Amphetamines; Anti-Anxiety Agents; Central Nervous System Stimulants; Chromatography, Liquid; Cocaine; Cotinine; Diazepam; Dopamine Uptake Inhibitors; Drug Overdose; Flunitrazepam; Forensic Medicine; Gas Chromatography-Mass Spectrometry; Hair; Humans; Morphine; Morphine Derivatives; Narcotics; Nicotine; Nicotinic Agonists; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection | 2004 |
Chronic exposure of cells expressing recombinant GABAA receptors to benzodiazepine antagonist flumazenil enhances the maximum number of benzodiazepine binding sites.
Topics: Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cell Membrane; Diazepam; Dose-Response Relationship, Drug; Drug Combinations; Flumazenil; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Humans; Kidney; Ligands; Receptors, GABA-A; Recombinant Proteins; Tritium | 2004 |
Synergistic interaction between hesperidin, a natural flavonoid, and diazepam.
Topics: Animals; Behavior, Animal; Benzodiazepines; Binding Sites; Binding, Competitive; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Flavonoids; Flunitrazepam; Hesperidin; Hypnotics and Sedatives; Ligands; Male; Mice; Radioligand Assay; Sleep; Tritium | 2005 |
Characterization in rats of the anxiolytic potential of ELB139 [1-(4-chlorophenyl)-4-piperidin-1-yl-1,5-dihydro-imidazol-2-on], a new agonist at the benzodiazepine binding site of the GABAA receptor.
Topics: Animals; Anti-Anxiety Agents; Binding Sites; Binding, Competitive; Conflict, Psychological; Diazepam; Drug Tolerance; Flumazenil; Flunitrazepam; GABA Agonists; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Imidazoles; Light; Male; Membrane Potentials; Patch-Clamp Techniques; Piperidines; Rats; Rats, Wistar | 2005 |
Ethyl 2-(4-bromophenyl)-1-(2,4-dichlorophenyl)-1H-4-imidazolecarboxylate is a novel positive modulator of GABAA receptors.
Topics: Animals; Binding, Competitive; Cell Membrane; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Etomidate; Female; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Glycine; Humans; Hydrocarbons, Halogenated; Imidazoles; Male; Membrane Potentials; Oocytes; Pentobarbital; Pregnanediones; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glycine; Receptors, Serotonin, 5-HT3; Serotonin; Tritium; Xenopus laevis | 2005 |
Alcohol and/or benzodiazepine use: different accidents--different impacts?
Topics: Accidents; Adult; Age Factors; Aged; Alcohol Drinking; Anti-Anxiety Agents; Central Nervous System Depressants; Diazepam; Emergency Service, Hospital; Ethanol; Female; Flunitrazepam; Humans; Injury Severity Score; Male; Middle Aged; Sex Factors; Time Factors; Trauma Centers | 2005 |
Normal [3H]flunitrazepam binding to GABAA receptors in the locus coeruleus in major depression and suicide.
Topics: Analysis of Variance; Anti-Anxiety Agents; Autoradiography; Binding, Competitive; Depression; Diazepam; Female; Flunitrazepam; Humans; Immunohistochemistry; Locus Coeruleus; Male; Middle Aged; Postmortem Changes; Receptors, GABA-A; Suicide; Tritium; Tyrosine 3-Monooxygenase | 2006 |
Characterization of two classes of benzodiazepine binding sites in Schistosoma mansoni.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Binding Sites; Clonazepam; Diazepam; Flunitrazepam; GABA Agonists; GABA Modulators; Inhibitory Concentration 50; Isoquinolines; Ligands; Male; Pyridines; Rats; Rats, Wistar; Receptors, GABA-A; Schistosoma mansoni; Synaptosomes; Temperature; Time Factors; Tritium; Zolpidem | 2007 |
Allosteric uncoupling and up-regulation of benzodiazepine and GABA recognition sites following chronic diazepam treatment of HEK 293 cells stably transfected with alpha1beta2gamma2S subunits of GABA (A) receptors.
Topics: Allosteric Regulation; Animals; Benzodiazepines; Binding Sites; Binding, Competitive; Cell Line; Diazepam; Flumazenil; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Muscimol; Picrotoxin; Protein Subunits; Pyridazines; Radioligand Assay; Rats; Receptors, GABA-A; Receptors, GABA-B; Transfection; Up-Regulation | 2007 |
Prediction of metabolic clearance using fresh human hepatocytes: comparison with cryopreserved hepatocytes and hepatic microsomes for five benzodiazepines.
Topics: Alprazolam; Benzodiazepines; Cell Survival; Cells, Cultured; Cryopreservation; Cytochrome P-450 CYP3A; Diazepam; Flunitrazepam; Hepatocytes; Humans; Metabolic Clearance Rate; Microsomes, Liver; Midazolam; Substrate Specificity; Triazolam | 2008 |
Differential effects of diazepam treatment and withdrawal on recombinant GABAA receptor expression and functional coupling.
Topics: Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cell Count; Cell Proliferation; Cell Survival; Cells, Cultured; Diazepam; Flunitrazepam; GABA Agonists; GABA Modulators; Gene Expression; Humans; Muscimol; Protein Binding; Protein Biosynthesis; Receptors, GABA-A; Transcriptional Activation | 2008 |
A high-throughput functional assay for characterization of gamma-aminobutyric acid(A) channel modulators using cryopreserved transiently transfected cells.
Topics: Carbolines; Cell Culture Techniques; Cell Line; Cell Membrane; Cryopreservation; Diazepam; DNA; Dose-Response Relationship, Drug; Drug Discovery; Flumazenil; Flunitrazepam; Fluorescent Dyes; Fluorobenzenes; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Membrane Potentials; Receptors, GABA-A; Reproducibility of Results; Spectrometry, Fluorescence; Transfection; Triazoles; Tritium | 2008 |
The effects of benzodiazepines on urotensin II-stimulated norepinephrine release from rat cerebrocortical slices.
Topics: Animals; Benzodiazepines; Benzoxazoles; Calcium Signaling; Cell Line; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; GABA-A Receptor Agonists; Humans; Hypnotics and Sedatives; In Vitro Techniques; Male; Midazolam; Naphthyridines; Norepinephrine; Orexin Receptors; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, GABA-A; Receptors, Neuropeptide; Transfection; Urea; Urotensins | 2009 |
Neuropharmacological screening of two 1,5-benzodiazepine compounds in mice.
Topics: Animals; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Benzopyrans; Diazepam; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Epilepsy, Tonic-Clonic; Flunitrazepam; GABA Agonists; Hexobarbital; Hypnotics and Sedatives; Male; Mice; Molecular Structure; Random Allocation; Receptors, GABA-A; Sleep | 2010 |
Benzodiazepine modulation of the rat GABAA receptor α4β3γ2L subtype expressed in Xenopus oocytes.
Topics: Animals; Benzodiazepines; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; HEK293 Cells; Humans; Oocytes; Patch-Clamp Techniques; Protein Subunits; Rats; Receptors, GABA-A; Xenopus | 2010 |
The effects of zolpidem treatment and withdrawal on the in vitro expression of recombinant alpha1beta2gamma2s GABA(A) receptors expressed in HEK 293 cells.
Topics: Animals; Binding Sites; Blotting, Western; Cell Line; Diazepam; Flunitrazepam; Humans; Hypnotics and Sedatives; Kidney; Protein Binding; Pyridines; Rats; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance Withdrawal Syndrome; Transfection; Up-Regulation; Zolpidem | 2010 |
Monitoring of benzodiazepine diversion using a multi-indicator approach.
Topics: Benzodiazepines; Clonazepam; Cross-Sectional Studies; Data Collection; Databases, Factual; Diazepam; Flunitrazepam; Humans; Prescription Drugs; Principal Component Analysis; Substance-Related Disorders | 2011 |
Rats with different thresholds for DMCM-induced clonic convulsions differ in the sleep-time of diazepam and [(3)H]-Ro 15-4513 binding.
Topics: Animals; Anticonvulsants; Autoradiography; Azides; Benzodiazepines; Carbolines; Convulsants; Diazepam; Differential Threshold; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Flunitrazepam; GABA Modulators; Male; Pentobarbital; Rats; Rats, Wistar; Reaction Time; Seizures; Sleep; Statistics, Nonparametric; Tritium | 2012 |
Short and long-term outcomes of endoscopic balloon dilatation for Crohn's disease strictures.
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Anastomosis, Surgical; Anti-Anxiety Agents; Constriction, Pathologic; Crohn Disease; Diazepam; Dilatation; Disease-Free Survival; Endoscopy; Female; Flunitrazepam; Humans; Male; Middle Aged; Models, Statistical; Retrospective Studies; Treatment Outcome; Young Adult | 2013 |
Effects of NOS inhibitors on the benzodiazepines-induced memory impairment of mice in the modified elevated plus-maze task.
Topics: Animals; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flunitrazepam; Indazoles; Male; Maze Learning; Memory Disorders; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Retention, Psychology | 2013 |
Anxiolytic-like effect of lavender essential oil inhalation in mice: participation of serotonergic but not GABAA/benzodiazepine neurotransmission.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Administration, Inhalation; Animals; Anti-Anxiety Agents; Behavior, Animal; Brain; Diazepam; Flunitrazepam; GABA-A Receptor Antagonists; Lavandula; Male; Mice; Motor Activity; Oils, Volatile; Picrotoxin; Piperazines; Plant Oils; Pyridines; Rats; Receptors, GABA-A; Serotonin Antagonists; Serotonin Receptor Agonists; Serotonin Syndrome; Synaptic Transmission | 2013 |
[Neuroleptic malignant syndrome after cardiac surgery].
Topics: Aortic Valve; Buprenorphine; Dantrolene; Diazepam; Endocarditis; Flunitrazepam; Humans; Male; Middle Aged; Mitral Valve; Muscle Relaxants, Central; Neuroleptic Malignant Syndrome | 2013 |
Production of human metabolites by gastrointestinal bacteria as a potential source of post-mortem alteration of antemortem drug/metabolite concentrations.
Topics: Anti-Anxiety Agents; Bacteroides fragilis; Biotransformation; Clostridium perfringens; Diazepam; Escherichia coli; Flunitrazepam; Gastrointestinal Tract; Humans; Hypnotics and Sedatives; Pilot Projects; Postmortem Changes; Tandem Mass Spectrometry | 2015 |
Dynamic high performance liquid chromatography on chiral stationary phases. Low temperature separation of the interconverting enantiomers of diazepam, flunitrazepam, prazepam and tetrazepam.
Topics: Benzodiazepines; Chromatography, High Pressure Liquid; Cold Temperature; Diazepam; Flunitrazepam; Magnetic Resonance Spectroscopy; Prazepam; Stereoisomerism | 2014 |
Production of monoclonal antibody against clonazepam for immunoassay of benzodiazepine drugs in swine tissues.
Topics: Animals; Antibodies, Monoclonal; Benzodiazepines; Clonazepam; Diazepam; Drug Residues; Flunitrazepam; Food Contamination; Haptens; Immunoassay; Kidney; Limit of Detection; Liver; Meat; Mice; Mice, Inbred BALB C; Muscles; Oxazepam; Serum Albumin; Swine; Tissue Distribution | 2015 |
Divergent effects of L-arginine-NO pathway modulators on diazepam and flunitrazepam responses in NOR task performance.
Topics: Animals; Arginine; Diazepam; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flunitrazepam; GABA Modulators; Indazoles; Male; Memory Disorders; Motor Activity; Nitric Oxide; Psychotropic Drugs; Rats, Wistar; Recognition, Psychology | 2015 |
Liquid chromatography-electron ionization tandem mass spectrometry with the Direct-EI interface in the fast determination of diazepam and flunitrazepam in alcoholic beverages.
Topics: Alcoholic Beverages; Chromatography, Liquid; Diazepam; Equipment Design; Flunitrazepam; Limit of Detection; Linear Models; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2016 |
l-NAME differential effects on diazepam and flunitrazepam responses of rats in the object recognition test.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Flunitrazepam; Male; NG-Nitroarginine Methyl Ester; Rats; Recognition, Psychology | 2016 |
Modification of NO-cGMP Pathway Differentially Affects Diazepam- and Flunitrazepam-Induced Spatial and Recognition Memory Impairments in Rodents.
Topics: Animals; Cyclic GMP; Diazepam; Dose-Response Relationship, Drug; Flunitrazepam; GABA Modulators; Male; Maze Learning; Nitric Oxide; Rats; Rats, Wistar; Recognition, Psychology; Rodentia; Signal Transduction; Spatial Memory | 2020 |
Incorporation of five common hypnotics into hair after a single dose and application to a forensic case of drug facilitated crimes.
Topics: Adult; Asian People; Chromatography, Liquid; Crime; Diazepam; Female; Flunitrazepam; Forensic Toxicology; Hair; Humans; Hypnotics and Sedatives; Male; Mass Spectrometry; Nitrazepam; Substance Abuse Detection; Triazolam; Zolpidem | 2021 |
Anxiety-like Behavior and GABAAR/BDZ Binding Site Response to Progesterone Withdrawal in a Stress-Vulnerable Strain, the Wistar Kyoto Rats.
Topics: Animals; Anxiety; Behavior, Animal; Binding Sites; Corticosterone; Diazepam; Female; Flunitrazepam; Hypothalamo-Hypophyseal System; Pituitary-Adrenal System; Progesterone; Rats; Rats, Inbred WKY; Receptors, GABA-A; Substance Withdrawal Syndrome | 2022 |