flunarizine has been researched along with stearic-acid* in 1 studies
1 other study(ies) available for flunarizine and stearic-acid
| Article | Year |
|---|---|
A novel flunarizine hydrochloride-loaded organogel for intraocular drug delivery in situ: Design, physicochemical characteristics and inspection.
We developed a safe and efficacious drug delivery system for treatment of brain diseases. A novel in-situ gel system was prepared using soybean oil, stearic acid and N-methyl-2-pyrrolidinone (NMP) (10:1:3, v/w/v). This system had low viscosity as a sol in vitro and turned into a solid or semi-solid gel in situ after administration. The poorly water-soluble drug flunarizine hydrochloride (FNZ) was incorporated into this "organogel" system. Organogel-FNZ was characterized by light microscopy, differential scanning calorimetry (DSC) and rheology. Drug release in vitro was investigated. The initial "burst" effect did not occur in organogel-FNZ, which is different from other gels formed in situ. Pharmacokinetic studies were undertaken in rats using gel administration (14 mg kg Topics: Administration, Intravenous; Administration, Ophthalmic; Animals; Biological Availability; Drug Carriers; Drug Compounding; Drug Liberation; Flunarizine; Gels; Male; Ophthalmic Solutions; Pyrrolidinones; Rabbits; Rats, Sprague-Dawley; Soybean Oil; Stearic Acids; Viscosity | 2020 |