flumazenil and zolpidem

flumazenil has been researched along with zolpidem in 99 studies

Research

Studies (99)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (4.04)	18.7374
1990's	35 (35.35)	18.2507
2000's	40 (40.40)	29.6817
2010's	20 (20.20)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Lüddens, H; Wieland, HA	1
Cook, JM; Hu, RJ; Liu, R; Skolnick, P; Zhang, P	1
Cook, JM; Dayer, CA; He, X; Huang, Q; Liu, R; Ma, C; McKernan, R; Wenger, GR; Yu, S	1
Besnard, F; Costa, B; Greco, G; Lavecchia, A; Marini, AM; Martini, C; Novellino, E; Primofiore, G; Settimo, FD; Taliani, S; Trincavelli, L	1
Besnard, F; Bruni, F; Ciciani, G; Costa, B; Costagli, C; Costanzo, A; Guerrini, G; Malmberg-Aiello, P; Martini, C; Selleri, S	1
Besnard, F; Cosimelli, B; Costa, B; Da Settimo, F; Greco, G; Martini, C; Montali, M; Novellino, E; Primofiore, G; Salerno, S; Taliani, S	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Besnard, F; Cosimelli, B; Da Settimo, F; Ehlardo, M; Greco, G; La Motta, C; Marini, AM; Martini, C; Montali, M; Novellino, E; Primofiore, G; Sala, A; Simorini, F; Taliani, S	1
Besnard, F; Calderone, V; Cosimelli, B; Da Settimo, F; Greco, G; La Motta, C; Marini, AM; Martini, C; Montali, M; Novellino, E; Patrizi, MP; Primofiore, G; Sergianni, V; Simorini, F; Taliani, S	1
Baur, R; Ernst, M; Goeldner, M; Gonthier, A; Sigel, E; Tan, KR	1
Lombardo, F; Obach, RS; Waters, NJ	1
Czajkowski, C; Hanson, SM; Morlock, EV; Satyshur, KA	1
Ahman, M; Holmén, AG; Wan, H	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Clayton, T; Cook, JM; Cromer, BA; Ma, C; Majumder, S; Namjoshi, OA; Petrou, S; Platt, DM; Roth, BL; VanLinn, ML; Yin, W	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Choi, Y; Raymer, BK	1
Arbilla, S; Benavides, J; Durand, A; Peny, B; Scatton, B	1
Byrnes, JJ; Greenblatt, DJ; Miller, LG	1
De Luca, C; De Medici, D; Massotti, M	1
Biggio, G; Carcangiu, G; Concas, A; Mereu, G; Passino, N	1
Blanchard, JC; Boireau, A; Doble, A; Dubedat, P; Laduron, PM	1
Askenasi, R; De Witte, O; Debailleul, G; Lheureux, P	1
Danielou, G; Lloyd, GK; Thuret, F	1
Benavides, J; Dubois, A; Morel, E; Peny, B; Perrault, G; Scatton, B; Zivkovic, B	1
Sanger, DJ; Zivkovic, B	2
Sanger, DJ	1
Bottlaender, M; Brouillet, E; Fournier, D; Fuseau, C; Mazière, M; Schmid, L	1
Cohen, C; Sanger, DJ	1
Bannwarth, W; Benke, D; Fritschy, JM; Mohler, H; Trzeciak, A	1
Dubruc, C; Forster, A; Naef, MM; Patat, A; Rosenzweig, P; van Gessel, E	1
Benavides, J; Peny, B; Ruano, D; Scatton, B; Vitorica, J	1
Auta, J; Costa, E; Guidotti, A; Kozikowski, A; Ma, D; Romeo, E	1
Gage, TW	1
Balkin, TJ; Belenky, GL; Davis, HQ; Wesensten, NJ	1
Meier-Abt, PJ; Radovanovic, D; Wyss, PA	1
Hadingham, KL; Palmer, KJ; Thompson, SA; Wafford, KA; Whiting, PJ	1
Blanc, P; Carbajal, R; Hoenn, E; Lenclen, R; Olivier-Martin, M; Paupe, A; Simon, N	1
Araujo, F; Benavides, J; Ruano, D; Schoemaker, H; Tan, S; Vitorica, J	1
Abadie, P; Baron, JC; Barré, L; Patat, A; Rioux, P; Scatton, B; Zarifian, E	1
Baur, R; Buhr, A; Sigel, E	1
Aks, S; Burda, T; Fischbein, C; Leikin, JB; Woods, K	1
Benke, D; Fritschy, JM; Johnson, DK; Mohler, H; Rudolph, U	1
Ator, NA; Grech, DM; Griffiths, RR; Weerts, EM	1
Atack, JR; McKernan, RM; Smith, AJ	1
Griffiths, RR; Weerts, EM	1
Burton, JH; Dorfman, T; Lyon, L; Tomassoni, AJ	1
Leeuwin, RS; van Wilgenburg, H; Zeegers, A	1
Atack, JR; Emms, F; McKernan, RM; Smith, AJ	1
Araujo, F; Ruano, D; Vitorica, J	1
Avenet, P; Granger, P; Griebel, G; Letang, V; Perrault, G; Sanger, DJ; Schoemaker, H	1
Chen, S; Kometiani, P; Lilly, SM; Rosenberg, HC; Tietz, EI; Zeng, XJ	1
Lelas, S; Rowlett, JK; Spealman, RD	1
Bannister, AP; Hughes, DI; Pawelzik, H; Thomson, AM	1
Atack, JR; Chadha, A; Duty, S; Howell, O; Sur, C	1
Firestone, LL; Homanics, GE; Quinlan, JJ	1
Ansaldo, MA; Fedele, E; Raiteri, M; Varnier, G	1
Betti, L; Bistocchi, M; Giannaccini, G; Gori, M; Lucacchini, A	1
Cook, JM; Ma, C; Miczek, KA; Rowlett, JK; Tornatzky, W	1
Bromidge, FA; Casula, MA; Hadingham, KL; Martin, K; Maubach, K; Pillai, GV; Seabrook, GR; Whiting, PJ; Wingrove, PB	1
Bergman, J; Cook, JM; Cox, ED; Paronis, CA	1
Carter, L; Cook, JM; France, CP; Gerak, LR; Ma, C; McMahon, LR	1
Safo, P; Thompson, SA; Wafford, KA; Wheat, L; Whiting, PJ; Wingrove, PB	1
Copolov, D; Dean, B; McLeod, M; Pralong, D	1
Cook, J; Ma, C; Platt, DM; Rowlett, JK; Spealman, RD	1
Clauss, RP; Dormehl, IC; Kilian, E; Louw, WK; Nel, WH; Oliver, DW	1
Haga, C	1
Chen, L; Savio Chan, C; Yung, WH	1
Foster, AC; Grigoriadis, DE; Gross, RS; Petroski, RE; Sullivan, SK; Verge, G	1
Bokonjić, DR; Cook, JM; Obradović, DI; Savić, MM; Ugresić, ND; Yin, W	1
Bokonjić, DR; Cook, JM; Obradović, DI; Sarma, PV; Savić, MM; Ugresić, ND	1
Dean, B; McLeod, M; Scarr, E	1
Fornasiero, A; Gerra, G; Lechi, A; Lugoboni, F; Mezzelani, P; Quaglio, G	1
Cook, JM; Duke, AN; Huang, S; Mattingly, BA; Platt, DM; Rowlett, JK; Yin, W	1
Besheer, J; Hodge, CW; Lepoutre, V; Mole, B	1
Groenink, L; Olivier, B; Oosting, R; Toth, M; Van Bogaert, M; van Oorschot, R	1
Chen, L; Fung, KS; Xie, JX; Yung, WH	1
Capasso, A; Cavallo, F; Raffa, RB	1
Heikkinen, AE; Korpi, ER; Möykkynen, TP	1
Bittencourt, PL; Cavalcanti, AR; da Silva, VC; Pinho, S; Zollinger, CC	1
Allen, MS; Brian Nofsinger, J; Hopkins, SC; Koch, P; Varney, MA	1
Atack, JR; Cook, JM; Dawson, GR; Licata, SC; Platt, DM; Rowlett, JK; Rüedi-Bettschen, D; Van Linn, ML	1
Hellsten, KS; Hyde, TM; Kleinman, JE; Korpi, ER; Maksimow, A; Särkioja, T; Sinkkonen, ST; Uusi-Oukari, M	1
Czopowicz, M; Frymus, T; Szalus-Jordanow, O	1
Cook, JM; Divljaković, J; Milić, M; Rallapalli, S; Savić, MM; Timić, T; van Linn, ML	1
Casari, R; Faccini, M; Licata, M; Lugoboni, F; Mathewson, S; Quaglio, G; Vigneau, CV	1
Cook, JM; Groenink, L; Hansen, HH; Mirza, NR; Nielsen, EØ; Olivier, B; van Oorschot, R; Vinkers, CH	1
Cook, JM; Fischer, BD; Namjoshi, OA; Rowlett, JK; Teixeira, LP; van Linn, ML	1
Gunja, N	1
Cho, S; Han, D; Jin, YH; Jin, Z; Kim, IH; Kim, S	1
Bienkowski, P; Kolaczkowski, M; Korkosz, A; Kostowski, W; Mierzejewski, P; Nowak, N; Samochowiec, J; Scinska, A; Sienkiewicz-Jarosz, H	1
Carstairs, SD; Negus, E; Thornton, SL	1
Hall, SD; Jones, RS; Ladds, G; Prokic, EJ; Stanford, IM; Weston, C; Woodhall, GL; Yamawaki, N	1
Cho, NC; Cho, S; Kim, J; Lee, CJ; Pae, AN; Park, KD; Um, MY; Woo, J; Yang, H; Yoon, M	1

Reviews

3 review(s) available for flumazenil and zolpidem

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Sleep modulating agents. Bioorganic & medicinal chemistry letters, 2019, 08-15, Volume: 29, Issue:16 Topics: Animals; Humans; Sleep; Sleep Aids, Pharmaceutical; Sleep Wake Disorders; Wakefulness-Promoting Agents	2019
The clinical and forensic toxicology of Z-drugs. Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2013, Volume: 9, Issue:2 Topics: Acetamides; Azabicyclo Compounds; Coma; Drug Overdose; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; Humans; Hypnotics and Sedatives; Piperazines; Pyridines; Pyrimidines; Zolpidem	2013

Trials

3 trial(s) available for flumazenil and zolpidem

Article	Year
Flumazenil antagonizes the central effects of zolpidem, an imidazopyridine hypnotic. Clinical pharmacology and therapeutics, 1994, Volume: 56, Issue:4 Topics: Adult; Analysis of Variance; Cross-Over Studies; Double-Blind Method; Flumazenil; Humans; Hypnotics and Sedatives; Male; Memory; Psychomotor Performance; Pyridines; Zolpidem	1994
Reversal of triazolam- and zolpidem-induced memory impairment by flumazenil. Psychopharmacology, 1995, Volume: 121, Issue:2 Topics: Administration, Oral; Adolescent; Adult; Flumazenil; Humans; Hypnotics and Sedatives; Male; Memory; Placebo Effect; Pyridines; Time Factors; Triazolam; Volunteers; Zolpidem	1995
Emergency department use of flumazenil prior to poison center consultation. Veterinary and human toxicology, 1997, Volume: 39, Issue:4 Topics: Antidotes; Benzodiazepines; Contraindications; Drug Overdose; Flumazenil; Humans; Hypnotics and Sedatives; Poison Control Centers; Pyridines; Treatment Outcome; Zolpidem	1997

Other Studies

93 other study(ies) available for flumazenil and zolpidem

Article	Year
Four amino acid exchanges convert a diazepam-insensitive, inverse agonist-preferring GABAA receptor into a diazepam-preferring GABAA receptor. Journal of medicinal chemistry, 1994, Dec-23, Volume: 37, Issue:26 Topics: Amino Acid Sequence; Azides; Base Sequence; Benzodiazepines; Binding Sites; Diazepam; GABA Agonists; Humans; Molecular Sequence Data; Mutation; Receptors, GABA-A; Structure-Activity Relationship	1994
Synthesis and pharmacological properties of novel 8-substituted imidazobenzodiazepines: high-affinity, selective probes for alpha 5-containing GABAA receptors. Journal of medicinal chemistry, 1996, Apr-26, Volume: 39, Issue:9 Topics: Animals; Benzodiazepines; Cerebellum; Flunitrazepam; Hippocampus; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mice; Molecular Probes; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Structure-Activity Relationship	1996
Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach. Journal of medicinal chemistry, 2000, Jan-13, Volume: 43, Issue:1 Topics: Animals; Benzodiazepines; Carbolines; Cell Line; Columbidae; Conditioning, Operant; Crystallography, X-Ray; Humans; Indoles; Ligands; Male; Models, Molecular; Pyrimidines; Quinolones; Radioligand Assay; Receptors, GABA-A; Saimiri; Stereoisomerism; Structure-Activity Relationship	2000
Novel N-(arylalkyl)indol-3-ylglyoxylylamides targeted as ligands of the benzodiazepine receptor: synthesis, biological evaluation, and molecular modeling analysis of the structure-activity relationships. Journal of medicinal chemistry, 2001, Jul-05, Volume: 44, Issue:14 Topics: Amides; Animals; Brain; Cattle; Glyoxylates; In Vitro Techniques; Indoles; Ligands; Models, Molecular; Radioligand Assay; Receptors, GABA-A; Structure-Activity Relationship	2001
Benzodiazepine receptor ligands. 7. Synthesis and pharmacological evaluation of new 3-esters of the 8-chloropyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide. 3-(2-Thienylmethoxycarbonyl) derivative: an anxioselective agent in rodents. Journal of medicinal chemistry, 2002, Dec-19, Volume: 45, Issue:26 Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Avoidance Learning; Cell Line; Cerebral Cortex; Cyclic N-Oxides; Drug Interactions; Ethanol; Exploratory Behavior; GABA Agents; Heterocyclic Compounds, 3-Ring; Humans; In Vitro Techniques; Ligands; Memory; Mice; Motor Skills; Neuromuscular Agents; Rats; Receptors, GABA-A; Seizures; Sleep; Structure-Activity Relationship; Triazines	2002
High affinity central benzodiazepine receptor ligands: synthesis and biological evaluation of a series of phenyltriazolobenzotriazindione derivatives. Journal of medicinal chemistry, 2005, Apr-21, Volume: 48, Issue:8 Topics: Animals; Binding, Competitive; Brain; Cattle; Cell Line; Chlorides; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Humans; In Vitro Techniques; Models, Molecular; Protein Isoforms; Radioligand Assay; Rats; Recombinant Proteins; Structure-Activity Relationship; Triazines; Triazoles	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Refinement of the benzodiazepine receptor site topology by structure-activity relationships of new N-(heteroarylmethyl)indol-3-ylglyoxylamides. Journal of medicinal chemistry, 2006, Apr-20, Volume: 49, Issue:8 Topics: Amides; Animals; Binding Sites; Binding, Competitive; Cell Line; GABA-A Receptor Antagonists; Humans; Hydrogen Bonding; Indoles; Ligands; Molecular Structure; Rats; Stereoisomerism; Structure-Activity Relationship	2006
Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-selective ligands. Journal of medicinal chemistry, 2007, Apr-05, Volume: 50, Issue:7 Topics: Amides; Animals; Cattle; Cell Line; Cerebral Cortex; GABA-A Receptor Agonists; Glyoxylates; Hypnotics and Sedatives; In Vitro Techniques; Indoles; Ligands; Male; Mice; Mice, Inbred BALB C; Molecular Conformation; Motor Activity; Radioligand Assay; Rats; Structure-Activity Relationship	2007
Proximity-accelerated chemical coupling reaction in the benzodiazepine-binding site of gamma-aminobutyric acid type A receptors: superposition of different allosteric modulators. The Journal of biological chemistry, 2007, Sep-07, Volume: 282, Issue:36 Topics: Allosteric Regulation; Allosteric Site; Amino Acid Substitution; Benzodiazepines; Central Nervous System Agents; Cysteine; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Humans; Ligands; Models, Molecular; Mutation, Missense; Protein Isoforms; Receptors, GABA-A; Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for eszopiclone and zolpidem binding to the gamma-aminobutyric acid type-A (GABAA) receptor are different. Journal of medicinal chemistry, 2008, Nov-27, Volume: 51, Issue:22 Topics: Azabicyclo Compounds; Benzodiazepines; Binding Sites; Cell Line; Computer Simulation; Cysteine; DNA Mutational Analysis; Eszopiclone; GABA-A Receptor Agonists; Humans; Hydrogen Bonding; Ligands; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Piperazines; Pyridines; Receptors, GABA-A; Structure-Activity Relationship; Zolpidem	2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6 Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Design, synthesis, and subtype selectivity of 3,6-disubstituted β-carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents for treatment of alcohol abuse. Bioorganic & medicinal chemistry, 2010, Nov-01, Volume: 18, Issue:21 Topics: Alcoholism; Animals; Benzodiazepines; Binding Sites; Carbolines; Cell Line; Computer Simulation; GABA-A Receptor Antagonists; Humans; Protein Subunits; Rats; Receptors, GABA-A; Stereoisomerism; Structure-Activity Relationship	2010
Comparative in vivo and in vitro regional selectivity of central omega (benzodiazepine) site ligands in inhibiting [3H]flumazenil binding in the rat central nervous system. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 263, Issue:2 Topics: Animals; Benzodiazepines; Binding Sites; Binding, Competitive; Brain Chemistry; Cell Membrane; Central Nervous System; Flumazenil; Hypnotics and Sedatives; Pyridazines; Pyridines; Rats; Receptors, GABA-A; Triazolam; Zolpidem	1992
Benzodiazepine receptor binding of nonbenzodiazepines in vivo: alpidem, zolpidem and zopiclone. Brain research bulletin, 1992, Volume: 29, Issue:6 Topics: Animals; Anti-Anxiety Agents; Azabicyclo Compounds; Brain; Cerebellum; Cerebral Cortex; Dose-Response Relationship, Drug; Flumazenil; Hippocampus; Hypnotics and Sedatives; Imidazoles; Male; Mice; Mice, Inbred Strains; Piperazines; Pyridines; Receptors, GABA-A; Reference Values; Zolpidem	1992
Relative efficacies of benzodiazepine receptor agonists in affecting red nucleus electrical activity in rabbits. Psychopharmacology, 1990, Volume: 102, Issue:4 Topics: Animals; Bicuculline; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; Imidazoles; Isoquinolines; Male; Pentylenetetrazole; Pyridazines; Pyridines; Rabbits; Receptors, GABA-A; Red Nucleus; Zolpidem	1990
Reduction of reticulata neuronal activity by zolpidem and alpidem, two imidazopyridines with high affinity for type I benzodiazepine receptors. European journal of pharmacology, 1990, Apr-25, Volume: 179, Issue:3 Topics: Action Potentials; Animals; Anti-Anxiety Agents; Diazepam; Flumazenil; Hypnotics and Sedatives; Imidazoles; Male; Neurons; Pyridines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Reticular Formation; Zolpidem	1990
Preferential decrease in dopamine utilization in prefrontal cortex by zopiclone, diazepam and zolpidem in unstressed rats. The Journal of pharmacy and pharmacology, 1990, Volume: 42, Issue:8 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Azabicyclo Compounds; Cerebral Cortex; Corpus Striatum; Diazepam; Dopamine; Flumazenil; Male; Piperazines; Pyridines; Rats; Rats, Inbred Strains; Stress, Physiological; Zolpidem	1990
Zolpidem intoxication mimicking narcotic overdose: response to flumazenil. Human & experimental toxicology, 1990, Volume: 9, Issue:2 Topics: Adult; Antidotes; Coma; Ethanol; Flumazenil; Humans; Hypnotics and Sedatives; Male; Narcotics; Pyridines; Zolpidem	1990
The activity of zolpidem and other hypnotics within the gamma-aminobutyric acid (GABAA) receptor supramolecular complex, as determined by 35S-t-butylbicyclophosphorothionate (35S-TBPS) binding to rat cerebral cortex membranes. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:2 Topics: Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Hypnotics and Sedatives; In Vitro Techniques; Male; Pyridines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Zolpidem	1990
In vivo interaction of zolpidem with central benzodiazepine (BZD) binding sites (as labeled by [3H]Ro 15-1788) in the mouse brain. Preferential affinity of zolpidem for the omega 1 (BZD1) subtype. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 245, Issue:3 Topics: Animals; Autoradiography; Binding Sites; Brain; Flumazenil; Flunitrazepam; Hypnotics and Sedatives; In Vitro Techniques; Male; Mice; Pyridazines; Pyridines; Receptors, GABA-A; Zolpidem	1988
The discriminative stimulus properties of zolpidem, a novel imidazopyridine hypnotic. Psychopharmacology, 1986, Volume: 89, Issue:3 Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Conditioning, Operant; Discrimination Learning; Dose-Response Relationship, Drug; Flumazenil; Generalization, Psychological; Hypnotics and Sedatives; Male; Pyridines; Rats; Rats, Inbred Strains; Zolpidem	1986
Investigation of the actions of the benzodiazepine antagonists Ro 15-1788 and CGS 8216 using the schedule-controlled behavior of rats. Pharmacology, biochemistry, and behavior, 1986, Volume: 25, Issue:3 Topics: Animals; Anxiety; Behavior, Animal; Benzodiazepines; Diazepam; Drug Interactions; Flumazenil; Male; Pyrazoles; Pyridines; Rats; Rats, Inbred Strains; Zolpidem	1986
Further behavioural evidence for the selective sedative action of zolpidem. Neuropharmacology, 1988, Volume: 27, Issue:11 Topics: Animals; Chlordiazepoxide; Conditioning, Operant; Eating; Exploratory Behavior; Flumazenil; Hypnotics and Sedatives; Male; Punishment; Pyridines; Rats; Rats, Inbred Strains; Zolpidem	1988
Zolpidem displays heterogeneity in its binding to the nonhuman primate benzodiazepine receptor in vivo. Journal of neurochemistry, 1995, Volume: 65, Issue:4 Topics: Animals; Binding Sites; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Flumazenil; Male; Papio; Pyridines; Receptors, GABA-A; Tissue Distribution; Zolpidem	1995
Effects of chronic treatment with triazolam on operant responding in rats. Pharmacology, biochemistry, and behavior, 1994, Volume: 49, Issue:3 Topics: Animals; Conditioning, Operant; Drug Tolerance; Flumazenil; Hypnotics and Sedatives; Male; Pyridines; Rats; Rats, Wistar; Reinforcement Schedule; Time Factors; Triazolam; Zolpidem	1994
Distribution, prevalence, and drug binding profile of gamma-aminobutyric acid type A receptor subtypes differing in the beta-subunit variant. The Journal of biological chemistry, 1994, Oct-28, Volume: 269, Issue:43 Topics: Animals; Brain Chemistry; Carbolines; Flumazenil; Flunitrazepam; Genetic Variation; Immunohistochemistry; Male; Microscopy, Confocal; Molecular Weight; Precipitin Tests; Protein Conformation; Pyridazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Tissue Distribution; Zolpidem	1994
Comparative autoradiographic distribution of central omega (benzodiazepine) modulatory site subtypes with high, intermediate and low affinity for zolpidem and alpidem. Brain research, 1993, Feb-26, Volume: 604, Issue:1-2 Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Autoradiography; Binding, Competitive; Brain; Flumazenil; Hypnotics and Sedatives; Imidazoles; Kinetics; Male; Organ Specificity; Pyridazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Spinal Cord; Tritium; Zolpidem	1993
Participation of mitochondrial diazepam binding inhibitor receptors in the anticonflict, antineophobic and anticonvulsant action of 2-aryl-3-indoleacetamide and imidazopyridine derivatives. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:2 Topics: Aggression; Allosteric Regulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Clonazepam; Desoxycorticosterone; Flumazenil; Imidazoles; Indoleacetic Acids; Isoniazid; Isoquinolines; Mitochondria; Phobic Disorders; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, GABA-A; Seizures; Zolpidem	1993
New drugs from 1991-1992. Texas dental journal, 1993, Volume: 110, Issue:7 Topics: 1-Naphthylamine; Anti-Bacterial Agents; Anti-Infective Agents; Anticholesteremic Agents; Antineoplastic Agents; Antiviral Agents; Azithromycin; Butanones; Cardiovascular Agents; Clarithromycin; Drug Approval; Drug Combinations; Drug Interactions; Enoxacin; Finasteride; Flumazenil; Fluoroquinolones; Humans; Ketorolac Tromethamine; Lactams; Nabumetone; Pyridines; Quinolones; Sertraline; Tolmetin; Tromethamine; United States; United States Food and Drug Administration; Zolpidem	1993
[Acute overdose of Zolpidem (Stilnox)]. Schweizerische medizinische Wochenschrift, 1996, May-04, Volume: 126, Issue:18 Topics: Adolescent; Adult; Aged; Antidotes; Coma; Drug Overdose; Female; Flumazenil; Humans; Hypnotics and Sedatives; Male; Midazolam; Middle Aged; Pyridines; Retrospective Studies; Triazolam; Zolpidem	1996
Expression and pharmacology of human GABAA receptors containing gamma 3 subunits. European journal of pharmacology, 1995, Nov-30, Volume: 291, Issue:3 Topics: Amino Acid Sequence; Animals; Anti-Anxiety Agents; Base Sequence; Benzodiazepines; Benzodiazepinones; Carbolines; Flumazenil; Flunitrazepam; GABA Modulators; Humans; Molecular Sequence Data; Pyrazoles; Pyridazines; Pyridines; Receptors, GABA-A; Recombinant Proteins; Sequence Homology, Amino Acid; Triazolam; Xenopus; Zolpidem	1995
[Flumazenil in zolpidem poisoning in children]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 1996, Volume: 3, Issue:2 Topics: Antidotes; Child, Preschool; Female; Flumazenil; Humans; Hypnotics and Sedatives; Male; Pyridines; Zolpidem	1996
Molecular and pharmacological characterization of native cortical gamma-aminobutyric acidA receptors containing both alpha1 and alpha3 subunits. The Journal of biological chemistry, 1996, Nov-01, Volume: 271, Issue:44 Topics: Amino Acid Sequence; Animals; Anti-Anxiety Agents; Antibodies; Binding Sites; Cattle; Cell Membrane; Cerebral Cortex; Chromatography, Affinity; Flumazenil; Hypnotics and Sedatives; Immunoblotting; Kinetics; Macromolecular Substances; Models, Structural; Peptide Fragments; Pyridazines; Pyridines; Rats; Rats, Wistar; Receptors, GABA-A; Zolpidem	1996
Central benzodiazepine receptor occupancy by zolpidem in the human brain as assessed by positron emission tomography. European journal of pharmacology, 1996, Jan-04, Volume: 295, Issue:1 Topics: Adult; Brain; Flumazenil; Humans; Male; Pyridines; Radioligand Assay; Receptors, GABA-A; Time Factors; Tissue Distribution; Tomography, Emission-Computed; Zolpidem	1996
Subtle changes in residue 77 of the gamma subunit of alpha1beta2gamma2 GABAA receptors drastically alter the affinity for ligands of the benzodiazepine binding site. The Journal of biological chemistry, 1997, May-02, Volume: 272, Issue:18 Topics: Animals; Benzodiazepines; Binding Sites; Cell Line; Diazepam; Female; Flumazenil; Humans; Kinetics; Macromolecular Substances; Mutagenesis, Site-Directed; Oocytes; Phenylalanine; Point Mutation; Pyridines; Radioligand Assay; Rats; Receptors, GABA-A; Recombinant Proteins; Transfection; Xenopus laevis; Zolpidem	1997
GABAA-receptor alpha-subunit is an essential prerequisite for receptor formation in vivo. Neuroscience, 1997, Volume: 81, Issue:4 Topics: Animals; Autoradiography; Brain Chemistry; Chromosome Deletion; Flumazenil; GABA Modulators; Hypnotics and Sedatives; Immunohistochemistry; Kinetics; Membranes; Mice; Mutation; Pyridines; Radioligand Assay; Receptors, GABA-A; Zolpidem	1997
Zolpidem physical dependence assessed across increasing doses under a once-daily dosing regimen in baboons. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 285, Issue:1 Topics: Animals; Behavior, Animal; Flumazenil; GABA Modulators; Hypnotics and Sedatives; Male; Papio; Pyridines; Substance Withdrawal Syndrome; Zolpidem	1998
Benzodiazepine modulation of recombinant alpha1beta3gamma2 GABA(A) receptor function efficacy determination using the Cytosensor microphysiometer. European journal of pharmacology, 1998, Oct-23, Volume: 359, Issue:2-3 Topics: Animals; Benzodiazepines; Benzodiazepinones; Biosensing Techniques; Cell Count; Cells, Cultured; Dose-Response Relationship, Drug; Eukaryotic Cells; Flumazenil; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Humans; Pyridines; Receptors, GABA-A; Recombinant Proteins; Time Factors; Zolpidem	1998
Zolpidem self-injection with concurrent physical dependence under conditions of long-term continuous availability in baboons. Behavioural pharmacology, 1998, Volume: 9, Issue:3 Topics: Animals; Behavior, Animal; Body Weight; Flumazenil; Food; GABA Modulators; Hypnotics and Sedatives; Injections, Intravenous; Male; Papio; Pyridines; Self Administration; Substance Withdrawal Syndrome; Substance-Related Disorders; Zolpidem	1998
Continuous flumazenil infusion in the treatment of zolpidem (Ambien) and ethanol coingestion. Journal of toxicology. Clinical toxicology, 1998, Volume: 36, Issue:7 Topics: Antidotes; Depressive Disorder; Ethanol; Female; Flumazenil; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Middle Aged; Poisoning; Pyridines; Suicide, Attempted; Zolpidem	1998
Cardiac effects of benzodiazepine receptor agonists and antagonists in the isolated rat heart: a comparative study. Life sciences, 1998, Volume: 63, Issue:16 Topics: Animals; Benzodiazepines; Cardiac Output; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Female; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Heart; In Vitro Techniques; Isoquinolines; Myocardial Contraction; Perfusion; Pyridines; Rats; Receptors, GABA-A; Zolpidem	1998
Regional differences in the inhibition of mouse in vivo [3H]Ro 15-1788 binding reflect selectivity for alpha 1 versus alpha 2 and alpha 3 subunit-containing GABAA receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1999, Volume: 20, Issue:3 Topics: Animals; Benzodiazepines; Binding Sites; Cerebellum; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; In Vitro Techniques; Ligands; Male; Mice; Pyridazines; Pyridines; Receptors, GABA-A; Spinal Cord; Time Factors; Tritium; Zolpidem	1999
Native gamma-aminobutyric acid type A receptors from rat hippocampus, containing both alpha 1 and alpha 5 subunits, exhibit a single benzodiazepine binding site with alpha 5 pharmacological properties. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:3 Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Binding Sites; Chromatography, Affinity; Flumazenil; GABA Modulators; Hippocampus; Hypnotics and Sedatives; Macromolecular Substances; Precipitin Tests; Pyridazines; Pyridines; Rats; Rats, Wistar; Receptors, GABA-A; Tritium; Zolpidem	1999
New evidence that the pharmacological effects of benzodiazepine receptor ligands can be associated with activities at different BZ (omega) receptor subtypes. Psychopharmacology, 1999, Volume: 146, Issue:2 Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Benzodiazepines; Binding, Competitive; Carbolines; Diazepam; Flumazenil; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Hypnotics and Sedatives; Ligands; Male; Mice; Mice, Inbred BALB C; Motor Activity; Muscle Relaxants, Central; Patch-Clamp Techniques; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Zolpidem	1999
Antagonist-induced reversal of functional and structural measures of hippocampal benzodiazepine tolerance. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:3 Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Autoradiography; Behavior, Animal; Benzodiazepines; Convulsants; Drug Tolerance; Electrophysiology; Flumazenil; Flurazepam; GABA Modulators; GABA-A Receptor Antagonists; Hippocampus; Hypnotics and Sedatives; Immunohistochemistry; Male; Patch-Clamp Techniques; Pentylenetetrazole; Pyridines; Rats; Rats, Sprague-Dawley; Seizures; Zolpidem	1999
Discriminative stimulus effects of zolpidem in squirrel monkeys: comparison with conventional benzodiazepines and sedative-hypnotics. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:3 Topics: Animals; Benzodiazepines; Discrimination, Psychological; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; Hypnotics and Sedatives; Male; Midazolam; Pyridines; Saimiri; Zolpidem	1999
Differential sensitivity to Zolpidem of IPSPs activated by morphologically identified CA1 interneurons in slices of rat hippocampus. The European journal of neuroscience, 2000, Volume: 12, Issue:2 Topics: Animals; Diazepam; Evoked Potentials; Flumazenil; GABA Agonists; GABA Modulators; Hippocampus; Interneurons; Male; Presynaptic Terminals; Pyramidal Cells; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Zolpidem	2000
Changes in [3H]zolpidem and [3H]Ro 15-1788 binding in rat globus pallidus and substantia nigra pars reticulata following a nigrostriatal tract lesion. Brain research, 2000, Apr-17, Volume: 862, Issue:1-2 Topics: Animals; Autoradiography; Flumazenil; GABA Agonists; GABA Modulators; Globus Pallidus; Male; Nerve Degeneration; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Substantia Nigra; Tritium; Zolpidem	2000
Mice lacking the long splice variant of the gamma 2 subunit of the GABA(A) receptor are more sensitive to benzodiazepines. Pharmacology, biochemistry, and behavior, 2000, Volume: 66, Issue:2 Topics: Alternative Splicing; Animals; Azides; Benzodiazepines; Brain; Carbolines; Diazepam; Drug Resistance; Female; Flumazenil; GABA Modulators; Genetic Variation; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Midazolam; Pyridines; Receptors, GABA-A; Sleep; Zolpidem	2000
Benzodiazepine-sensitive GABA(A) receptors limit the activity of the NMDA/NO/cyclic GMP pathway: a microdialysis study in the cerebellum of freely moving rats. Journal of neurochemistry, 2000, Volume: 75, Issue:2 Topics: Animals; Anti-Anxiety Agents; Bicuculline; Cerebellum; Cyclic GMP; Diazepam; Flumazenil; Infusions, Parenteral; Kinetics; Male; Microdialysis; Muscimol; N-Methylaspartate; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Zolpidem	2000
[3H]Ro 15-1788 binding sites to brain membrane of the saltwater Mugil cephalus. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2001, Volume: 128, Issue:3 Topics: Animals; Binding Sites; Binding, Competitive; Brain; Carbolines; Cell Membrane; Chlorides; Diazepam; Female; Fishes; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Imidazoles; Ionophores; Male; Pyridines; Receptors, GABA-A; Synaptosomes; Tritium; Zolpidem	2001
Zolpidem, triazolam, and diazepam decrease distress vocalizations in mouse pups: differential antagonism by flumazenil and beta-Carboline-3-carboxylate-t-butyl ester (beta-CCt). The Journal of pharmacology and experimental therapeutics, 2001, Volume: 297, Issue:1 Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Body Temperature; Carbolines; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GABA-A Receptor Antagonists; Mice; Pyridines; Receptors, GABA-A; Triazolam; Vocalization, Animal; Zolpidem	2001
Identification of amino acid residues responsible for the alpha5 subunit binding selectivity of L-655,708, a benzodiazepine binding site ligand at the GABA(A) receptor. Journal of neurochemistry, 2001, Volume: 77, Issue:2 Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Anti-Anxiety Agents; Azides; Benzodiazepines; Binding Sites; Binding, Competitive; Carbolines; DNA, Complementary; Female; Flumazenil; Flunitrazepam; GABA-A Receptor Agonists; Humans; Imidazoles; Isoleucine; Ligands; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Protein Binding; Protein Structure, Tertiary; Protein Subunits; Pyridazines; Pyridines; Receptors, GABA-A; Recombinant Fusion Proteins; Sequence Alignment; Structure-Activity Relationship; Threonine; Transfection; Xenopus laevis; Zolpidem	2001
Different types of GABA(A) receptors may mediate the anticonflict and response rate-decreasing effects of zaleplon, zolpidem, and midazolam in squirrel monkeys. Psychopharmacology, 2001, Volume: 156, Issue:4 Topics: Acetamides; Animals; Carbolines; Dose-Response Relationship, Drug; Flumazenil; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; Hypnotics and Sedatives; Male; Midazolam; Pyridines; Pyrimidines; Reaction Time; Receptors, GABA-A; Saimiri; Zolpidem	2001
Discriminative stimulus effects of benzodiazepine (BZ)(1) receptor-selective ligands in rhesus monkeys. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 300, Issue:2 Topics: Acetamides; Animals; Carbolines; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Hypnotics and Sedatives; Ligands; Macaca mulatta; Midazolam; Pyridines; Pyrimidines; Receptors, GABA-A; Zolpidem	2002
Mechanism of alpha-subunit selectivity of benzodiazepine pharmacology at gamma-aminobutyric acid type A receptors. European journal of pharmacology, 2002, Feb-15, Volume: 437, Issue:1-2 Topics: Animals; Anti-Anxiety Agents; Binding, Competitive; Cell Line; Diazepam; Dose-Response Relationship, Drug; Female; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Membrane Potentials; Mutation; Oocytes; Protein Subunits; Pyridazines; Pyridines; Radioligand Assay; Receptors, GABA-A; Tritium; Xenopus laevis; Zolpidem	2002
The heterogeneity of central benzodiazepine receptor subtypes in the human hippocampal formation, frontal cortex and cerebellum using [3H]flumazenil and zolpidem. Brain research. Molecular brain research, 2002, Aug-15, Volume: 104, Issue:2 Topics: Cerebellum; Clonazepam; Flumazenil; Frontal Lobe; GABA Agents; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; Humans; Male; Middle Aged; Neurons; Protein Binding; Pyridines; Radioligand Assay; Receptors, GABA-A; Synaptic Transmission; Tritium; Zolpidem	2002
Selective antagonism of the ataxic effects of zolpidem and triazolam by the GABAA/alpha1-preferring antagonist beta-CCt in squirrel monkeys. Psychopharmacology, 2002, Volume: 164, Issue:2 Topics: Animals; Ataxia; Benzodiazepines; Carbolines; Dose-Response Relationship, Drug; Drug Interactions; Flumazenil; GABA Agonists; GABA Modulators; GABA-A Receptor Antagonists; Male; Motor Activity; Pyridines; Receptors, GABA-A; Saimiri; Social Behavior; Triazolam; Zolpidem	2002
Cerebral blood perfusion after treatment with zolpidem and flumazenil in the baboon. Arzneimittel-Forschung, 2002, Volume: 52, Issue:10 Topics: Algorithms; Animals; Brain; Cerebrovascular Circulation; Flumazenil; GABA Modulators; Hypnotics and Sedatives; Male; Nervous System Diseases; Papio; Pyridines; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Exametazime; Zolpidem	2002
[Poisonings with benzodiazepine-like drugs]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2003, Feb-20, Volume: 123, Issue:4 Topics: Acetamides; Antidotes; Azabicyclo Compounds; Flumazenil; Humans; Hypnotics and Sedatives; Norway; Piperazines; Poisoning; Pyridines; Pyrimidines; Zolpidem	2003
Electrophysiological and behavioral effects of zolpidem in rat globus pallidus. Experimental neurology, 2004, Volume: 186, Issue:2 Topics: Action Potentials; Animals; Animals, Newborn; Behavior, Animal; Drug Interactions; Electrophysiology; Flumazenil; GABA Agonists; GABA Modulators; Globus Pallidus; In Vitro Techniques; Motor Activity; Patch-Clamp Techniques; Pyridines; Rats; Rats, Sprague-Dawley; Synapses; Zolpidem	2004
Characterization of the interaction of indiplon, a novel pyrazolopyrimidine sedative-hypnotic, with the GABAA receptor. The Journal of pharmacology and experimental therapeutics, 2004, Volume: 311, Issue:2 Topics: Acetamides; Animals; Azides; Benzodiazepines; Binding Sites; Brain; Cell Membrane; Cerebellum; Cerebral Cortex; Chloride Channels; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Kinetics; Male; Pyridines; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Thiophenes; Triazolam; Tritium; Zolpidem	2004
Bidirectional effects of benzodiazepine binding site ligands in the elevated plus-maze: differential antagonism by flumazenil and beta-CCt. Pharmacology, biochemistry, and behavior, 2004, Volume: 79, Issue:2 Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Binding Sites; Carbolines; Drug Interactions; Flumazenil; GABA Modulators; Ligands; Male; Maze Learning; Mice; Midazolam; Pyridines; Rats; Rats, Wistar; Receptors, GABA-A; Zolpidem	2004
Bidirectional effects of benzodiazepine binding site ligands on active avoidance acquisition and retention: differential antagonism by flumazenil and beta-CCt. Psychopharmacology, 2005, Volume: 180, Issue:3 Topics: Animals; Anti-Anxiety Agents; Avoidance Learning; Benzodiazepines; Binding Sites; Carbolines; Convulsants; Dose-Response Relationship, Drug; Flumazenil; GABA Agonists; GABA Modulators; GABA-A Receptor Agonists; Habituation, Psychophysiologic; Injections, Intraperitoneal; Ligands; Male; Midazolam; Motor Activity; Pyridines; Rats; Rats, Wistar; Receptors, GABA-A; Retention, Psychology; Zolpidem	2005
Changes in hippocampal GABAA receptor subunit composition in bipolar 1 disorder. Brain research. Molecular brain research, 2005, Aug-18, Volume: 138, Issue:2 Topics: Adult; Aged; Binding, Competitive; Bipolar Disorder; Brain Chemistry; Clonazepam; Female; Flumazenil; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; Humans; Male; Middle Aged; Muscimol; Protein Subunits; Pyridines; Radioligand Assay; Receptors, GABA-A; Schizophrenia; Zolpidem	2005
Dependence on zolpidem: two case reports of detoxification with flumazenil infusion. International clinical psychopharmacology, 2005, Volume: 20, Issue:5 Topics: Adult; Antidotes; Flumazenil; Half-Life; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Male; Pyridines; Substance-Related Disorders; Zolpidem	2005
Enhanced sucrose pellet consumption induced by benzodiazepine-type drugs in squirrel monkeys: role of GABAA receptor subtypes. Psychopharmacology, 2006, Volume: 187, Issue:3 Topics: Alprazolam; Animals; Benzodiazepines; Diazepam; Flumazenil; Male; Pyridines; Receptors, GABA-A; Saimiri; Sucrose; Zolpidem	2006
GABAA receptor regulation of voluntary ethanol drinking requires PKCepsilon. Synapse (New York, N.Y.), 2006, Volume: 60, Issue:6 Topics: Alcohol Drinking; Animals; Diazepam; Flumazenil; GABA Agonists; GABA Modulators; Hypnotics and Sedatives; Mice; Mice, Knockout; Motor Activity; Protein Kinase C-epsilon; Pyridines; Receptors, GABA-A; Zolpidem	2006
Effects of genetic background and null mutation of 5-HT1A receptors on basal and stress-induced body temperature: modulation by serotonergic and GABAA-ergic drugs. European journal of pharmacology, 2006, Nov-21, Volume: 550, Issue:1-3 Topics: Animals; Body Temperature; Body Temperature Regulation; Buspirone; Diazepam; Fever; Flumazenil; Fluorobenzenes; GABA Agonists; GABA Modulators; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pyridines; Receptor, Serotonin, 5-HT1A; Receptors, GABA-A; Serotonin; Serotonin Agents; Serotonin Receptor Agonists; Stress, Psychological; Triazoles; Zolpidem	2006
Zolpidem modulates GABA(A) receptor function in subthalamic nucleus. Neuroscience research, 2007, Volume: 58, Issue:1 Topics: Animals; Flumazenil; GABA Agonists; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Motor Activity; Neural Inhibition; Neural Pathways; Neurons; Organ Culture Techniques; Parkinson Disease; Patch-Clamp Techniques; Pyridines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, GABA-A; Subthalamic Nucleus; Synaptic Transmission; Time Factors; Zolpidem	2007
Flumazenil-sensitive dose-related physical dependence in planarians produced by two benzodiazepine and one non-benzodiazepine benzodiazepine-receptor agonists. European journal of pharmacology, 2007, Jun-14, Volume: 564, Issue:1-3 Topics: Analysis of Variance; Animals; Benzodiazepines; Clorazepate Dipotassium; Dose-Response Relationship, Drug; Flumazenil; GABA Agonists; GABA Modulators; Locomotion; Midazolam; Planarians; Pyridines; Receptors, GABA-A; Reproducibility of Results; Substance Withdrawal Syndrome; Substance-Related Disorders; Zolpidem	2007
Long-lasting modulation of glutamatergic transmission in VTA dopamine neurons after a single dose of benzodiazepine agonists. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009, Volume: 34, Issue:2 Topics: Animals; Benzodiazepines; Diazepam; Dizocilpine Maleate; Ethanol; Excitatory Postsynaptic Potentials; Female; Flumazenil; GABA-A Receptor Agonists; Glutamic Acid; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Morphine; Neurons; Patch-Clamp Techniques; Pyridines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Ventral Tegmental Area; Zolpidem	2009
Delayed-onset hepatic encephalopathy induced by zolpidem: a case report. Clinics (Sao Paulo, Brazil), 2008, Volume: 63, Issue:4 Topics: Aged; Delayed-Action Preparations; Female; Flumazenil; GABA Modulators; Hepatic Encephalopathy; Humans; Hypnotics and Sedatives; Pyridines; Zolpidem	2008
In vivo saturation binding of GABA-A receptor ligands to estimate receptor occupancy using liquid chromatography/tandem mass spectrometry. Biopharmaceutics & drug disposition, 2009, Volume: 30, Issue:1 Topics: Algorithms; Animals; Azabicyclo Compounds; Binding Sites; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Flumazenil; Fluorobenzenes; GABA Agonists; GABA Modulators; Hypnotics and Sedatives; In Vitro Techniques; Indicators and Reagents; Ligands; Male; Mice; Models, Statistical; Piperazines; Pyridines; Receptors, GABA-A; Stereoisomerism; Tandem Mass Spectrometry; Triazoles; Zolpidem	2009
Discriminative stimulus effects of L-838,417 (7-tert-butyl-3-(2,5-difluoro-phenyl)-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-[1,2,4]triazolo[4,3-b]pyridazine): role of GABA(A) receptor subtypes. Neuropharmacology, 2010, Volume: 58, Issue:2 Topics: Animals; Barbiturates; Carbolines; Catheterization; Central Nervous System Depressants; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Ethanol; Flumazenil; Fluorobenzenes; GABA Agonists; GABA Antagonists; GABA Modulators; Neuropsychological Tests; Pyridines; Receptors, GABA-A; Saimiri; Triazoles; Zolpidem	2010
Human locus coeruleus neurons express the GABA(A) receptor gamma2 subunit gene and produce benzodiazepine binding. Neuroscience letters, 2010, Jun-21, Volume: 477, Issue:2 Topics: Adult; Autoradiography; Azides; Benzodiazepines; Female; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Humans; Locus Coeruleus; Male; Melanins; Neurons; Pyridines; Radioligand Assay; Receptors, GABA-A; Tyrosine 3-Monooxygenase; Zolpidem	2010
Zolpidem poisoning in a cat. Australian veterinary journal, 2010, Volume: 88, Issue:8 Topics: Animals; Antidotes; Ataxia; Cat Diseases; Cats; Flumazenil; Hyperkinesis; Hypnotics and Sedatives; Male; Pyridines; Zolpidem	2010
The role of α1 and α5 subunit-containing GABAA receptors in motor impairment induced by benzodiazepines in rats. Behavioural pharmacology, 2012, Volume: 23, Issue:2 Topics: Animals; Ataxia; Benzodiazepines; Benzodiazepinones; Carbolines; Diazepam; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Hand Strength; Imidazoles; Male; Muscle Relaxation; Pyridines; Rats; Rats, Wistar; Receptors, GABA-A; Rotarod Performance Test; Zolpidem	2012
Megadose bromazepam and zolpidem dependence: two case reports of treatment with flumazenil and valproate. Substance abuse, 2012, Volume: 33, Issue:2 Topics: Adult; Anticonvulsants; Bromazepam; Female; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; Humans; Pyridines; Substance-Related Disorders; Valproic Acid; Zolpidem	2012
GABA(A) receptor α subunits differentially contribute to diazepam tolerance after chronic treatment. PloS one, 2012, Volume: 7, Issue:8 Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Benzodiazepinones; Body Temperature; Brain; Diazepam; DNA Primers; Drug Tolerance; Flumazenil; Hypnotics and Sedatives; In Situ Hybridization; Male; Mice; Mice, Mutant Strains; Pyridazines; Pyridines; Receptors, GABA-A; Triazoles; Zolpidem	2012
Role of gamma-aminobutyric acid type A (GABAA) receptor subtypes in acute benzodiazepine physical dependence-like effects: evidence from squirrel monkeys responding under a schedule of food presentation. Psychopharmacology, 2013, Volume: 227, Issue:2 Topics: Animals; Benzodiazepines; Chlordiazepoxide; Conditioning, Operant; Dose-Response Relationship, Drug; Flumazenil; Food; GABA Antagonists; GABA Modulators; Imidazoles; Pyridines; Receptors, GABA-A; Reinforcement Schedule; Saimiri; Substance-Related Disorders; Time Factors; Zolpidem	2013
Potentiating effect of glabridin on GABAA receptor-mediated responses in dorsal raphe neurons. Planta medica, 2013, Volume: 79, Issue:15 Topics: Animals; Anti-Anxiety Agents; Brain; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GABA Agents; gamma-Aminobutyric Acid; Glycyrrhiza; Hypnotics and Sedatives; Isoflavones; Neurons; Pentobarbital; Phenols; Plant Extracts; Plant Roots; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Zolpidem	2013
Pharmacological characteristics of zolpidem-induced catalepsy in the rat. Neuroscience letters, 2013, Nov-27, Volume: 556 Topics: Animals; Catalepsy; Dizocilpine Maleate; Dose-Response Relationship, Drug; Flumazenil; GABA-A Receptor Antagonists; Hypnotics and Sedatives; Male; Naltrexone; Narcotic Antagonists; Pyridines; Quinpirole; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Time Factors; Zolpidem	2013
Pediatric zolpidem ingestion demonstrating zero-order kinetics treated with flumazenil. Pediatric emergency care, 2013, Volume: 29, Issue:11 Topics: Antidotes; Central Nervous System Depressants; Child; Coma; Down Syndrome; Drug Overdose; Emergencies; Flumazenil; Half-Life; Humans; Hypnotics and Sedatives; Male; Molecular Structure; Poisoning; Pyridines; Zolpidem	2013
Cortical oscillatory dynamics and benzodiazepine-site modulation of tonic inhibition in fast spiking interneurons. Neuropharmacology, 2015, Volume: 95 Topics: Action Potentials; Animals; Beta Rhythm; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Interneurons; Kinetics; Male; Models, Neurological; Patch-Clamp Techniques; Pyramidal Cells; Pyridines; Rats, Wistar; Receptors, GABA-A; Tissue Culture Techniques; Zolpidem	2015
α-Pinene, a Major Constituent of Pine Tree Oils, Enhances Non-Rapid Eye Movement Sleep in Mice through GABAA-benzodiazepine Receptors. Molecular pharmacology, 2016, Volume: 90, Issue:5 Topics: Animals; Benzodiazepines; Bicyclic Monoterpenes; Binding Sites; Eye Movements; Flumazenil; Inhibitory Postsynaptic Potentials; Male; Mice, Inbred C57BL; Mice, Inbred ICR; Models, Molecular; Monoterpenes; Pentobarbital; Pinus; Plant Oils; Pyridines; Receptors, GABA-A; Sleep; Sleep, REM; Time Factors; Wakefulness; Zolpidem	2016