flumazenil has been researched along with valproic acid in 33 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (30.30) | 18.7374 |
| 1990's | 4 (12.12) | 18.2507 |
| 2000's | 6 (18.18) | 29.6817 |
| 2010's | 13 (39.39) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Hamilton, MS; Shephard, RA | 1 |
| Aranko, K; File, SE | 1 |
| Akhundov, RA; Rozhanets, VV; Val'dman, AV; Voronina, TA | 1 |
| Moura, D; Soares-da-Silva, P | 1 |
| Jenkinson, S; Shephard, RA; Stevenson, D | 1 |
| Biziere, K; Calassi, R; Chambon, JP; Heaulme, M; Perio, A | 1 |
| Kunert-Radek, J; Pawlikowski, M; Stepień, H | 1 |
| Feldon, J; Lerner, T; Myslobodsky, M | 1 |
| Morag, M; Myslobodsky, M | 1 |
| Engel, JA; Liljequist, S | 1 |
| Bartenstein, PA; Brooks, DJ; Duncan, JS; Fish, DR; Lammertsma, AA; Patsalos, PN; Prevett, MC | 1 |
| Buchanan, N | 1 |
| Steinhoff, BJ; Stodieck, SR | 1 |
| Brooks, DJ; Cunningham, VJ; Duncan, JS; Koepp, MJ; Richardson, MP | 1 |
| Jutila, L; Kälviäinen, R; Lamusuo, S; Lehikoinen, P; Någren, K; Oikonen, V; Partanen, K; Pitkänen, A; Rinne, JO; Ruottinen, HM; Vainio, P; Vapalahti, M; Ylinen, A | 1 |
| Araki, H; Gomita, Y; Hashimoto, Y; Suemaru, K | 1 |
| Albiero, A; Bongiovanni, LG; Brigo, F; Casari, R; Faccini, M; Fiaschi, A; Lugoboni, F; Quaglio, G; Storti, M | 1 |
| Casari, R; Faccini, M; Licata, M; Lugoboni, F; Mathewson, S; Quaglio, G; Vigneau, CV | 1 |
| Dabole, B; Dawe, A; De Waard, M; Dimo, T; Djomeni Dzeufiet, PD; Ngo Bum, E; Okomolo Moto, FC; Sidiki, N; Sotoing Taïwe, G; Talla, E; Temkou Ngoupaye, G | 1 |
| Espinosa, JL; Martinez Miguel, P; Rodriguez Puyol, D; Samillán, K; Sencion Martinez, GL; Villa, P | 1 |
| Hoffmann, K; Janhsen, K; Roser, P | 1 |
| Bongiovanni, LG; Casari, R; Faccini, M; Federico, A; Franchini, E; Lugoboni, F; Morbioli, L; Tamburin, S | 1 |
3 review(s) available for flumazenil and valproic acid
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[Drug activation of GABAergic transmission in the central nervous system: benzodiazepines and GABAergic agonists].
Topics: Animals; Benzodiazepines; Benzodiazepinones; Brain; Carbolines; Chemical Phenomena; Chemistry; Cyclic GMP; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Humans; Receptors, GABA-A; Synaptic Transmission; Valproic Acid | 1985 |
The problems of long-term treatment with benzodiazepines and related substances.
Topics: Benzodiazepines; Carbamazepine; Flumazenil; Germany; Humans; Prevalence; Risk Factors; Substance Withdrawal Syndrome; Substance-Related Disorders; Valproic Acid | 2015 |
1 trial(s) available for flumazenil and valproic acid
| Article | Year |
|---|---|
[11 C]Flumazenil binding in the medial temporal lobe in patients with temporal lobe epilepsy: correlation with hippocampal MR volumetry, T2 relaxometry, and neuropathology.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Epilepsy, Temporal Lobe; Female; Flumazenil; GABA Modulators; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Temporal Lobe; Tomography, Emission-Computed; Treatment Outcome; Valproic Acid; Vigabatrin | 2000 |
29 other study(ies) available for flumazenil and valproic acid
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Chlordiazepoxide and valproate enhancement of saline drinking by nondeprived rats: effects of bicuculline, picrotoxin and Ro15-1788.
Topics: Animals; Bicuculline; Chlordiazepoxide; Dose-Response Relationship, Drug; Drinking Behavior; Drug Combinations; Drug Interactions; Flumazenil; Male; Picrotoxin; Rats; Rats, Inbred Strains; Sodium Chloride; Valproic Acid | 1989 |
Sodium valproate decreases exploratory behaviour in mice: development of tolerance and cross-tolerance with chlordiazepoxide.
Topics: Animals; Chlordiazepoxide; Drug Tolerance; Exploratory Behavior; Flumazenil; gamma-Aminobutyric Acid; Male; Mice; Motor Activity; Receptors, GABA-A; Valproic Acid | 1988 |
[Mechanism of the tranquilizing action of electron structural analogs of nicotinamide].
Topics: Animals; Benzodiazepinones; Bicuculline; Brain; Conflict, Psychological; Flumazenil; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Inosine; Male; Niacinamide; Radioligand Assay; Rats; Receptors, GABA-A; Serotonin; Synaptosomes; Tranquilizing Agents; Valproic Acid | 1986 |
Effects of valproate on hyponeophagia in rats: competitive antagonism with picrotoxin and non-competitive antagonism with RO 15-1788.
Topics: Animals; Benzodiazepinones; Dose-Response Relationship, Drug; Feeding Behavior; Flumazenil; Male; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Time Factors; Valproic Acid | 1985 |
Evaluation of two anticonvulsant amino-pyridazine derivatives in the conflict test in rats.
Topics: Animals; Anticonvulsants; Conflict, Psychological; Diazepam; Flumazenil; Meprobamate; Mice; Papio; Pentobarbital; Pyrazoles; Pyridazines; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Valproic Acid | 1986 |
Enhancement of estradiol-induced DNA synthesis in the anterior pituitary gland by the peripheral-type benzodiazepine receptor ligand Ro 5-4864.
Topics: Animals; Benzodiazepinones; DNA; Drug Synergism; Estradiol; Flumazenil; Male; Mitosis; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains; Valproic Acid | 1986 |
Anticonflict action of sodium valproate. Interaction with convulsant benzodiazepine (Ro 5-3663) and imidazodiazepine (Ro 15-1788).
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Conflict, Psychological; Convulsants; Drug Interactions; Flumazenil; Male; Valproic Acid | 1983 |
Benzodiazepine antagonists abolish electrophysiological effects of sodium valproate in the rat.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Diazepam; Evoked Potentials, Visual; Female; Flumazenil; gamma-Aminobutyric Acid; Immobilization; Kinetics; Male; Rats; Receptors, Drug; Receptors, GABA-A; Valproic Acid | 1982 |
Reversal of the anti-conflict action of valproate by various GABA and benzodiazepine antagonists.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Bicuculline; Conflict, Psychological; Flumazenil; GABA Antagonists; Male; Motor Activity; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Valproic Acid | 1984 |
Benzodiazepine-GABAA receptors in idiopathic generalized epilepsy measured with [11C]flumazenil and positron emission tomography.
Topics: Adolescent; Adult; Brain; Carbon Radioisotopes; Cerebral Cortex; Epilepsy, Absence; Female; Flumazenil; Humans; Male; Receptors, GABA; Tomography, Emission-Computed; Valproic Acid | 1995 |
Temporary abolition of seizure activity by flumazenil.
Topics: Flumazenil; Humans; Status Epilepticus; Valproic Acid | 1994 |
Temporary abolition of seizure activity by flumazenil in a case of valproate-induced non-convulsive status epilepticus.
Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Electroencephalography; Evoked Potentials; Female; Flumazenil; Humans; Midazolam; Phenobarbital; Seizures; Status Epilepticus; Valproic Acid | 1993 |
Central benzodiazepine/gamma-aminobutyric acid A receptors in idiopathic generalized epilepsy: an [11C]flumazenil positron emission tomography study.
Topics: Adult; Analysis of Variance; Brain; Carbon Radioisotopes; Cerebellum; Cerebral Cortex; Epilepsy, Generalized; Female; Flumazenil; Humans; Longitudinal Studies; Male; Middle Aged; Receptors, GABA-A; Thalamus; Tomography, Emission-Computed; Valproic Acid | 1997 |
Effects of drugs acting on the GABA-benzodiazepine receptor complex on flurothyl-induced seizures in Mongolian gerbils.
Topics: Amino Acids; Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Ethanol; Flumazenil; Flurothyl; GABA Antagonists; GABA-A Receptor Antagonists; Gerbillinae; Male; Picrotoxin; Receptors, GABA-A; Seizures; Valproic Acid | 2006 |
Focal nonconvulsive seizures during detoxification for benzodiazepine abuse.
Topics: Adult; Anticonvulsants; Benzodiazepines; Female; Flumazenil; GABA Modulators; Humans; Infusions, Intravenous; Middle Aged; Seizures; Substance Withdrawal Syndrome; Substance-Related Disorders; Valproic Acid | 2012 |
Megadose bromazepam and zolpidem dependence: two case reports of treatment with flumazenil and valproate.
Topics: Adult; Anticonvulsants; Bromazepam; Female; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; Humans; Pyridines; Substance-Related Disorders; Valproic Acid; Zolpidem | 2012 |
Antipsychotic and sedative effects of the leaf extract of Crassocephalum bauchiense (Hutch.) Milne-Redh (Asteraceae) in rodents.
Topics: Animals; Antipsychotic Agents; Apomorphine; Asteraceae; Behavior, Animal; Body Temperature; Brain; Catalepsy; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Agents; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Male; Medicine, African Traditional; Mice; Mice, Inbred Strains; Motor Activity; Pentobarbital; Phytotherapy; Plant Extracts; Plant Leaves; Psychotic Disorders; Rats, Sprague-Dawley; Receptors, GABA-A; Sleep; Valproic Acid | 2012 |
[Hemoperfusion with activated charcoal on valproic acid poisoning. A case report].
Topics: Benzodiazepines; Charcoal; Combined Modality Therapy; Depressive Disorder; Drug Overdose; Female; Flumazenil; Hemoperfusion; Humans; Hyperammonemia; Middle Aged; Naloxone; Olanzapine; Paranoid Disorders; Psychotropic Drugs; Respiration, Artificial; Suicide, Attempted; Valproic Acid | 2015 |
Low risk of seizures with slow flumazenil infusion and routine anticonvulsant prophylaxis for high-dose benzodiazepine dependence.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Antidotes; Benzodiazepines; Female; Flumazenil; Humans; Hypnotics and Sedatives; Levetiracetam; Male; Middle Aged; Piracetam; Quality of Life; Seizures; Substance-Related Disorders; Valproic Acid; Young Adult | 2017 |