Compounds > flumazenil

flumazenil and triazoles

flumazenil has been researched along with triazoles in 21 studies

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19902 (9.52)18.7374
1990's6 (28.57)18.2507
2000's8 (38.10)29.6817
2010's5 (23.81)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dudley, MW; Kane, JM; Kehne, JH; Miller, JA; Sorensen, SM1
Casals-Stenzel, J1
Griffin, K; Hong, T; Levy, JV1
Kuriyama, K; Tomono, S1
Bayley, P; Curnow, R; Dawson, GR; Rambridge, A; Tricklebank, MD1
Dalton, CR; Dudley, MW; Kane, JM; Kehne, JH; Ketteler, HJ; McCloskey, TC; Miller, FP; Ogden, AM; Senyah, Y; Staeger, MA1
Ambrogi, V; Giannaccini, G; Grandolini, G; Lucacchini, A; Martini, C; Perioli, L1
Sharma, A; Singh, M; Singh, N1
Atack, JR; Bristow, L; Brown, N; Carling, RW; Castro, JL; Cook, G; Dawson, GR; Farrar, S; Ferris, P; Garrett, L; Howell, O; Macaulay, A; Marshall, G; McKernan, RM; Moore, KW; Myers, J; Ragan, CI; Reynolds, DS; Rosahl, TW; Street, LJ; Sur, C; Wafford, KA; Whiting, PJ1
Atack, JR; Scott-Stevens, P; Sohal, B; Worboys, P1
Atack, JR; Bristow, L; Bromidge, F; Carling, R; Castro, JL; Cook, SM; Dawson, GR; Kerby, J; McKernan, RM; Melillo, D; Pike, A; Ragan, I; Sohal, B; Street, L; Sur, C; Tye, SJ; Wafford, KA; Whiting, P1
Groenink, L; Olivier, B; Oosting, R; Toth, M; Van Bogaert, M; van Oorschot, R1
Atack, JR; Bormans, G; Burns, HD; de Groot, T; de Hoon, J; De Lepeleire, I; Dupont, P; Hargreaves, RJ; Mortelmans, L; Sanabria-Bohórquez, SM; Van Laere, K1
Bostwick, R; Chen, T; Huston, J; Knappenberger, K; Liu, J; Norris, T; Wood, M1
Allen, MS; Brian Nofsinger, J; Hopkins, SC; Koch, P; Varney, MA1
Evenden, J; Jonak, G; Ross, L; Zhou, J1
Aigbirhio, FI; Atack, JR; Baron, JC; Beech, JS; Burns, HD; Dannals, RF; Eng, WS; Fryer, TD; Gibson, RE; Hargreaves, RJ; McKernan, RM; Ryan, C; Sanabria, S; Schrag, ML; Scott-Stevens, P; Sohal, B; Vega, JM; Vessy, L; Wong, DF; Zhou, Y1
Atack, JR; Cook, JM; Dawson, GR; Licata, SC; Platt, DM; Rowlett, JK; Rüedi-Bettschen, D; Van Linn, ML1
Eyanagi, R; Imoto, M; Kuroki, H; Nishimura, S; Shimeno, H; Soeda, S; Toda, A; Uchiyama, H; Watanabe, S1
Appel, L; Atack, JR; Bergstrom, M; Burns, HD; Dawson, GR; Eng, W; Hargreaves, RJ; Langstrom, B; Sanabria, S; Sciberras, D1
Cook, JM; Groenink, L; Hansen, HH; Mirza, NR; Nielsen, EØ; Olivier, B; van Oorschot, R; Vinkers, CH1

Reviews

1 review(s) available for flumazenil and triazoles

ArticleYear
Thieno-triazolo-1,4-diazepines as antagonists of platelet-activating factor: present status.
    Lipids, 1991, Volume: 26, Issue:12

    Topics: Animals; Azepines; Central Nervous System; Flumazenil; Humans; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Structure-Activity Relationship; Triazolam; Triazoles

1991

Trials

1 trial(s) available for flumazenil and triazoles

ArticleYear
In vivo characterization and dynamic receptor occupancy imaging of TPA023B, an alpha 2/alpha 3/alpha 5 subtype selective gamma-aminobutyric acid-a partial agonist.
    Biological psychiatry, 2008, Jul-15, Volume: 64, Issue:2

    Topics: Administration, Oral; Adult; Biological Availability; Brain; Carbon Radioisotopes; Double-Blind Method; Flumazenil; GABA Agonists; Humans; Kinetics; Male; Positron-Emission Tomography; Pyridazines; Receptors, GABA-A; Triazoles

2008

Other Studies

19 other study(ies) available for flumazenil and triazoles

ArticleYear
MDL 26,479: a potential cognition enhancer with benzodiazepine inverse agonist-like properties.
    British journal of pharmacology, 1992, Volume: 107, Issue:1

    Topics: Animals; Behavior, Animal; Benzodiazepines; Binding Sites; Carbolines; Cognition; Convulsants; Diazepam; Flumazenil; Hemicholinium 3; Hippocampus; In Vitro Techniques; Male; Mice; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Triazoles

1992
The benzodiazepine receptor ligands RO 5-4864 and RO 15-1788 do not block the inhibition of PAF-induced platelet aggregation seen with the hetrazepine WEB2086.
    Biochemical and biophysical research communications, 1989, Apr-14, Volume: 160, Issue:1

    Topics: Adenosine Triphosphate; Animals; Azepines; Benzodiazepinones; Blood Platelets; Female; Flumazenil; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, GABA-A; Triazines; Triazoles

1989
Effect of 450191-S, a 1H-1,2,4-triazolyl benzophenone derivative, on cerebral content of neuroactive amino acids.
    Japanese journal of pharmacology, 1985, Volume: 39, Issue:4

    Topics: Amino Acids; Animals; Anti-Anxiety Agents; Benzodiazepinones; Brain; Flumazenil; Male; Mice; Neurotransmitter Agents; Nitrazepam; Receptors, GABA-A; Triazoles

1985
Lack of effect of flumazenil and CGS 8216 on the anxiolytic-like properties of loreclezole.
    European journal of pharmacology, 1994, Feb-11, Volume: 252, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Convulsants; Drug Interactions; Flumazenil; Injections, Intraperitoneal; Male; Pyrazoles; Rats; Triazoles

1994
5-Aryl-3-(alkylthio)-4H-1,2,4-triazoles as selective antagonists of strychnine-induced convulsions and potential antispastic agents.
    Journal of medicinal chemistry, 1994, Jan-07, Volume: 37, Issue:1

    Topics: Animals; Anticonvulsants; Cerebellum; Cerebral Cortex; Chlorides; Electroshock; Flumazenil; Male; Mice; Molecular Structure; Muscle Spasticity; Paralysis; Rats; Rats, Sprague-Dawley; Seizures; Structure-Activity Relationship; Strychnine; Triazoles

1994
Studies on annelated 1,4-benzothiazines and 1,5-benzothiazepines. X--Synthesis and inhibition of benzodiazepine receptor binding of new 1,4-thiazine and 1,5-thiazepine polycondensed heterocycles with steroidal structure.
    Farmaco (Societa chimica italiana : 1989), 1996, Volume: 51, Issue:3

    Topics: Animals; Binding, Competitive; Cattle; Cerebral Cortex; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Quinolines; Receptors, GABA-A; Thiazines; Triazoles

1996
Possible mechanism of alprazolam-induced amnesia in mice.
    Pharmacology, 1998, Volume: 56, Issue:1

    Topics: Alprazolam; Amnesia; Animals; Azepines; Drug Evaluation, Preclinical; Female; Flumazenil; GABA Agonists; Male; Maze Learning; Mice; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thienopyridines; Triazoles

1998
Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.
    Nature neuroscience, 2000, Volume: 3, Issue:6

    Topics: Allosteric Site; Animals; Anti-Anxiety Agents; Anticonvulsants; Azides; Benzodiazepines; Binding, Competitive; Brain; Cell Line; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Fluorobenzenes; GABA-A Receptor Antagonists; Hypnotics and Sedatives; Ligands; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Motor Activity; Patch-Clamp Techniques; Receptors, GABA-A; Reflex, Startle; Triazoles

2000
Rodent pharmacokinetics and receptor occupancy of the GABAA receptor subtype selective benzodiazepine site ligand L-838417.
    Biopharmaceutics & drug disposition, 2005, Volume: 26, Issue:1

    Topics: Administration, Oral; Animals; Area Under Curve; Biological Availability; Brain; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Flumazenil; Fluorobenzenes; Injections, Intraperitoneal; Injections, Intravenous; Male; Mice; Mice, Transgenic; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Rodentia; Species Specificity; Triazoles; Tritium

2005
TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 316, Issue:1

    Topics: Acoustic Stimulation; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Anti-Anxiety Agents; Anticonvulsants; Autoradiography; Conditioning, Operant; Convulsants; Drinking; Emotions; Fear; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; Humans; Male; Mice; Pentylenetetrazole; Postural Balance; Protein Binding; Pyridazines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Recombinant Proteins; Reflex, Startle; Saimiri; Substance Withdrawal Syndrome; Triazoles

2006
Effects of genetic background and null mutation of 5-HT1A receptors on basal and stress-induced body temperature: modulation by serotonergic and GABAA-ergic drugs.
    European journal of pharmacology, 2006, Nov-21, Volume: 550, Issue:1-3

    Topics: Animals; Body Temperature; Body Temperature Regulation; Buspirone; Diazepam; Fever; Flumazenil; Fluorobenzenes; GABA Agonists; GABA Modulators; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pyridines; Receptor, Serotonin, 5-HT1A; Receptors, GABA-A; Serotonin; Serotonin Agents; Serotonin Receptor Agonists; Stress, Psychological; Triazoles; Zolpidem

2006
A high-throughput functional assay for characterization of gamma-aminobutyric acid(A) channel modulators using cryopreserved transiently transfected cells.
    Assay and drug development technologies, 2008, Volume: 6, Issue:6

    Topics: Carbolines; Cell Culture Techniques; Cell Line; Cell Membrane; Cryopreservation; Diazepam; DNA; Dose-Response Relationship, Drug; Drug Discovery; Flumazenil; Flunitrazepam; Fluorescent Dyes; Fluorobenzenes; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Membrane Potentials; Receptors, GABA-A; Reproducibility of Results; Spectrometry, Fluorescence; Transfection; Triazoles; Tritium

2008
In vivo saturation binding of GABA-A receptor ligands to estimate receptor occupancy using liquid chromatography/tandem mass spectrometry.
    Biopharmaceutics & drug disposition, 2009, Volume: 30, Issue:1

    Topics: Algorithms; Animals; Azabicyclo Compounds; Binding Sites; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Flumazenil; Fluorobenzenes; GABA Agonists; GABA Modulators; Hypnotics and Sedatives; In Vitro Techniques; Indicators and Reagents; Ligands; Male; Mice; Models, Statistical; Piperazines; Pyridines; Receptors, GABA-A; Stereoisomerism; Tandem Mass Spectrometry; Triazoles; Zolpidem

2009
A novel operant conflict procedure using incrementing shock intensities to assess the anxiolytic and anxiogenic effects of drugs.
    Behavioural pharmacology, 2009, Volume: 20, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Aripiprazole; Benzodiazepines; Chlordiazepoxide; Conditioning, Operant; Conflict, Psychological; Dextroamphetamine; Diazepam; Electroshock; Flumazenil; Male; Piperazines; Punishment; Pyridazines; Quinolones; Rats; Rats, Sprague-Dawley; Triazoles; Yohimbine

2009
Benzodiazepine binding site occupancy by the novel GABAA receptor subtype-selective drug 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in rats, primates, and humans.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 332, Issue:1

    Topics: Animals; Binding Sites; Brain; Dose-Response Relationship, Drug; Flumazenil; GABA Agonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Humans; Macaca mulatta; Papio; Positron-Emission Tomography; Protein Binding; Protein Subunits; Pyridazines; Radioligand Assay; Rats; Species Specificity; Tissue Distribution; Triazoles

2010
Discriminative stimulus effects of L-838,417 (7-tert-butyl-3-(2,5-difluoro-phenyl)-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-[1,2,4]triazolo[4,3-b]pyridazine): role of GABA(A) receptor subtypes.
    Neuropharmacology, 2010, Volume: 58, Issue:2

    Topics: Animals; Barbiturates; Carbolines; Catheterization; Central Nervous System Depressants; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Ethanol; Flumazenil; Fluorobenzenes; GABA Agonists; GABA Antagonists; GABA Modulators; Neuropsychological Tests; Pyridines; Receptors, GABA-A; Saimiri; Triazoles; Zolpidem

2010
The stimulatory effects of caffeine with oseltamivir (Tamiflu) on light-dark behavior and open-field behavior in mice.
    Neuroscience letters, 2010, Jan-22, Volume: 469, Issue:2

    Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Antiviral Agents; Caffeine; Darkness; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Exploratory Behavior; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Haloperidol; Male; Mice; Motor Activity; Neurotransmitter Agents; Oseltamivir; Pyrimidines; Random Allocation; Triazoles; Xanthines

2010
Occupancy of human brain GABA(A) receptors by the novel α5 subtype-selective benzodiazepine site inverse agonist α5IA as measured using [¹¹C]flumazenil PET imaging.
    Neuropharmacology, 2010, Volume: 59, Issue:7-8

    Topics: Adult; Brain; Carbon Radioisotopes; Drug Inverse Agonism; Flumazenil; GABA-A Receptor Agonists; Humans; Male; Phthalazines; Positron-Emission Tomography; Protein Subunits; Receptors, GABA-A; Triazoles; Young Adult

2010
GABA(A) receptor α subunits differentially contribute to diazepam tolerance after chronic treatment.
    PloS one, 2012, Volume: 7, Issue:8

    Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Benzodiazepinones; Body Temperature; Brain; Diazepam; DNA Primers; Drug Tolerance; Flumazenil; Hypnotics and Sedatives; In Situ Hybridization; Male; Mice; Mice, Mutant Strains; Pyridazines; Pyridines; Receptors, GABA-A; Triazoles; Zolpidem

2012