flumazenil has been researched along with pregnanolone in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (24.14) | 18.2507 |
| 2000's | 11 (37.93) | 29.6817 |
| 2010's | 10 (34.48) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Blakeman, DP; Im, WB | 1 |
| Fernández-Guasti, A; Picazo, O | 1 |
| Chen, SW; Davies, MF; Loew, GH; Rodriguez, L | 1 |
| Davies, PA; Hales, TG; Hanna, MC; Kirkness, EF | 1 |
| Akwa, Y; Britton, KT; Brot, MD; Koob, GF; Purdy, RH | 1 |
| Bender, AS; Norenberg, MD | 1 |
| Bitran, D; Dugan, M; Ellis, R; Foley, M; Renda, P | 1 |
| Gulinello, M; Smith, SS | 1 |
| Molina-Hernández, M; Olivera Lopez, JI; Pérez García, J; Tellez-Alcántara, NP; Teresa Jaramillo, M | 1 |
| Keller, AF; Leroy, C; Nehlig, A; Poisbeau, P | 1 |
| France, CP; McMahon, LR | 1 |
| Ahboucha, S; Butterworth, RF; Coyne, L; Halliwell, RF; Hirakawa, R | 1 |
| France, CP; Gerak, LR; McMahon, LR | 1 |
| France, CP; Javors, MA; McMahon, LR | 1 |
| Betts, BA; Gill, N; Griffith, TN; Hall, AC; Humbert, DJ; Jenkins, A; Kelly, EW; Kotey, FO; Rowan, KC; Veneskey, KC; Watt, EE | 1 |
| Kumar, A; Singh, A | 1 |
| Darbra, S; Pallarès, M | 1 |
| Fukami, G; Fukumoto, M; Hashimoto, K; Iyo, M; Muneoka, K; Shirayama, Y; Tadokoro, S | 1 |
| Gangisetty, O; Reddy, DS | 1 |
| Bai, X; Gerak, LR | 1 |
| France, CP; Gerak, LR | 2 |
| Bäckström, T; Bixo, M; Nyberg, S; Savic, I | 1 |
| France, CP; Gerak, LR; Yoon, SS; Zanettini, C | 1 |
| Bäckström, T; Helström, L; Möller, AT; Nyberg, S; Söndergaard, HP | 1 |
| do Rego, JL; Vaudry, D; Vaudry, H | 1 |
| Gerak, LR; Ibarra, MH; Pressly, JD; Smith, KR; Zanettini, C | 1 |
| Gallo, AT; Hulse, GK | 1 |
29 other study(ies) available for flumazenil and pregnanolone
| Article | Year |
|---|---|
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Correlation between gamma-aminobutyric acidA receptor ligand-induced changes in t-butylbicyclophosphoro[35S]thionate binding and 36Cl- uptake in rat cerebrocortical membranes.
Topics: Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Cerebral Cortex; Chloride Channels; Chlorides; Desoxycorticosterone; Diazepam; Ethanol; Flumazenil; gamma-Aminobutyric Acid; In Vitro Techniques; Ligands; Membrane Proteins; Pentobarbital; Pregnanolone; Rats; Receptors, GABA-A; Synaptosomes | 1991 |
Flumazenil blocks the anxiolytic action of allopregnanolone.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Drug Interactions; Female; Flumazenil; GABA Modulators; Pregnanolone; Rats; Rats, Wistar | 1995 |
The hyperphagic effect of 3 alpha-hydroxylated pregnane steroids in male rats.
Topics: Animals; Anxiety; Dose-Response Relationship, Drug; Eating; Feeding Behavior; Flumazenil; GABA Antagonists; GABA Modulators; GABA-A Receptor Antagonists; Male; Picrotoxin; Pregnanes; Pregnanolone; Rats; Rats, Sprague-Dawley | 1996 |
Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit.
Topics: Amino Acid Sequence; Anesthetics, Intravenous; Animals; Bicuculline; Brain; Cell Line; Consensus Sequence; DNA, Complementary; Flumazenil; Flunitrazepam; GABA Agents; gamma-Aminobutyric Acid; Humans; Molecular Sequence Data; Muscimol; Pentobarbital; Picrotoxin; Pregnanolone; Propofol; Rats; Receptors, GABA-A; Recombinant Proteins; RNA, Messenger; Transfection | 1997 |
The anxiolytic-like effects of the neurosteroid allopregnanolone: interactions with GABA(A) receptors.
Topics: Affinity Labels; Animals; Anti-Anxiety Agents; Anxiety; Azides; Behavior, Animal; Benzodiazepines; Binding Sites; Chloride Channels; Conflict, Psychological; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Female; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Organophosphorus Compounds; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A | 1997 |
Effect of benzodiazepines and neurosteroids on ammonia-induced swelling in cultured astrocytes.
Topics: Ammonia; Astrocytes; Atrial Natriuretic Factor; Benzodiazepines; Benzodiazepinones; Brain Edema; Cell Size; Clonazepam; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Diazepam; Diazepam Binding Inhibitor; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Isoquinolines; Nerve Tissue Proteins; Neuropeptides; Peptide Fragments; Pregnanolone; Pregnenolone; Protoporphyrins; Receptors, GABA-A; Steroids; Up-Regulation | 1998 |
Anxiolytic effects of the neuroactive steroid pregnanolone (3 alpha-OH-5 beta-pregnan-20-one) after microinjection in the dorsal hippocampus and lateral septum.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Chloride Channels; Dose-Response Relationship, Drug; Electroshock; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Hippocampus; Isoquinolines; Male; Microinjections; Picrotoxin; Pregnanolone; Rats; Rats, Long-Evans; Receptors, GABA-A; Septum of Brain | 1999 |
Anxiogenic effects of neurosteroid exposure: sex differences and altered GABAA receptor pharmacology in adult rats.
Topics: Acoustic Stimulation; Aging; Animals; Anti-Anxiety Agents; Anxiety; Exploratory Behavior; Female; Flumazenil; GABA Modulators; Lorazepam; Male; Pregnanolone; Progesterone; Rats; Rats, Long-Evans; Receptors, GABA-A; Reflex, Startle; Sex Characteristics | 2003 |
Anti-conflict-like actions of intralateral septal infusions of allopregnanolone in Wistar rats.
Topics: Animals; Behavior, Animal; Bicuculline; Conflict, Psychological; Dose-Response Relationship, Drug; Female; Flumazenil; Functional Laterality; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Gonadal Steroid Hormones; Ovariectomy; Pregnanolone; Rats; Rats, Wistar; Septum of Brain; Stereotaxic Techniques | 2003 |
Pharmacological plasticity of GABA(A) receptors at dentate gyrus synapses in a rat model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Diazepam; Disease Models, Animal; Electric Conductivity; Epilepsy, Temporal Lobe; Flumazenil; GABA Modulators; Lithium; Male; Neural Inhibition; Patch-Clamp Techniques; Pilocarpine; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Status Epilepticus; Synapses | 2004 |
Negative GABA(A) modulators attenuate the discriminative stimulus effects of benzodiazepines and the neuroactive steroid pregnanolone in rhesus monkeys.
Topics: Animals; Benzodiazepines; Carbolines; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Female; Flumazenil; Macaca mulatta; Male; Midazolam; Pregnanolone; Receptors, GABA-A; Serotonin Antagonists; Serotonin Receptor Agonists | 2005 |
An interaction between benzodiazepines and neuroactive steroids at GABA A receptors in cultured hippocampal neurons.
Topics: Affinity Labels; Allosteric Regulation; Animals; Azides; Benzodiazepines; Cells, Cultured; Chloride Channels; Dose-Response Relationship, Drug; Drug Interactions; Female; Flumazenil; GABA Modulators; Hepatic Encephalopathy; Hippocampus; Male; Neural Inhibition; Neurons; Patch-Clamp Techniques; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Synaptic Transmission | 2006 |
Efficacy and the discriminative stimulus effects of negative GABAA modulators, or inverse agonists, in diazepam-treated rhesus monkeys.
Topics: Animals; Azides; Benzodiazepines; Conditioning, Operant; Cues; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Agonists; GABA Modulators; Hypnotics and Sedatives; Macaca mulatta; Male; Pentobarbital; Pregnanolone; Receptors, GABA-A | 2006 |
Changes in relative potency among positive GABA(A) receptor modulators upon discontinuation of chronic benzodiazepine treatment in rhesus monkeys.
Topics: Animals; Behavior, Animal; Benzodiazepines; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Modulators; Lorazepam; Macaca mulatta; Male; Midazolam; Pentobarbital; Pregnanediones; Pregnanolone; Receptors, GABA-A; Substance Withdrawal Syndrome | 2007 |
Menthol shares general anesthetic activity and sites of action on the GABA(A) receptor with the intravenous agent, propofol.
Topics: Anesthetics, General; Anesthetics, Intravenous; Animals; Cyclohexanols; Flumazenil; Flunitrazepam; Menthol; Pentobarbital; Pregnanolone; Propofol; Receptors, GABA-A; Xenopus | 2008 |
Possible GABAergic modulation in the protective effect of allopregnanolone on sleep deprivation-induced anxiety-like behavior and oxidative damage in mice.
Topics: Animals; Anxiety; Behavior, Animal; Body Weight; Catalase; Dose-Response Relationship, Drug; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; Glutathione; Lipid Peroxidation; Male; Maze Learning; Mice; Motor Activity; Muscimol; Neuroprotective Agents; Nitrites; Oxidative Stress; Picrotoxin; Pregnanolone; Sleep Deprivation | 2008 |
Neonatal allopregnanolone increases novelty-directed locomotion and disrupts behavioural responses to GABA(A) receptor modulators in adulthood.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Exploratory Behavior; Flumazenil; GABA Modulators; Isoxazoles; Lorazepam; Male; Maze Learning; Midazolam; Motor Activity; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A | 2009 |
Infusions of allopregnanolone into the hippocampus and amygdala, but not into the nucleus accumbens and medial prefrontal cortex, produce antidepressant effects on the learned helplessness rats.
Topics: Amygdala; Animals; Antidepressive Agents; Avoidance Learning; CA3 Region, Hippocampal; Depression; Disease Models, Animal; Dizocilpine Maleate; Drug Combinations; Flumazenil; GABA Antagonists; Helplessness, Learned; Humans; Injections, Intraventricular; Male; Nucleus Accumbens; Prefrontal Cortex; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, N-Methyl-D-Aspartate | 2011 |
Neurosteroid withdrawal regulates GABA-A receptor α4-subunit expression and seizure susceptibility by activation of progesterone receptor-independent early growth response factor-3 pathway.
Topics: Animals; Diazepam; Drug Administration Schedule; Early Growth Response Protein 3; Female; Flumazenil; Gene Expression Regulation; Hippocampus; Kindling, Neurologic; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurotransmitter Agents; Oligodeoxyribonucleotides, Antisense; Pregnanolone; Progesterone; Receptors, GABA-A; Receptors, Progesterone; Signal Transduction; Up-Regulation | 2010 |
Comparing the discriminative stimuli produced by either the neuroactive steroid pregnanolone or the benzodiazepine midazolam in rats.
Topics: Animals; Behavior, Animal; Discrimination, Psychological; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; GABA Modulators; Male; Midazolam; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2011 |
Quantitative analyses of antagonism: combinations of midazolam and either flunitrazepam or pregnanolone in rhesus monkeys discriminating midazolam.
Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Female; Flumazenil; Flunitrazepam; Macaca mulatta; Midazolam; Pregnanolone; Receptors, GABA-A | 2012 |
Increased neurosteroid sensitivity--an explanation to symptoms associated with chronic work related stress in women?
Topics: Adult; Burnout, Professional; Employment; Female; Flumazenil; GABA Modulators; Humans; Middle Aged; Pregnanolone; Saccades; Stress, Psychological; Women | 2013 |
Acute tolerance to chlordiazepoxide qualitatively changes the interaction between flumazenil and pregnanolone and not the interaction between flumazenil and midazolam in rhesus monkeys discriminating midazolam.
Topics: Animals; Benzodiazepines; Chlordiazepoxide; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Female; Flumazenil; GABA Modulators; Macaca mulatta; Midazolam; Pregnanolone | 2013 |
Discriminative stimulus effects of pregnanolone in rhesus monkeys.
Topics: Animals; Conditioning, Operant; Data Interpretation, Statistical; Discrimination, Psychological; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Flumazenil; Flunitrazepam; GABA Modulators; Gonadal Steroid Hormones; Hypnotics and Sedatives; Isoxazoles; Macaca mulatta; Male; Midazolam; Pregnanolone; Receptors, GABA-A; Reinforcement Schedule | 2014 |
Women with PTSD have a changed sensitivity to GABA-A receptor active substances.
Topics: Adolescent; Adult; Anxiety; Diagnostic and Statistical Manual of Mental Disorders; Diazepam; Female; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; Humans; Hypnotics and Sedatives; Pregnanolone; Psychiatric Status Rating Scales; Receptors, GABA-A; Saccades; Stress Disorders, Post-Traumatic; Young Adult | 2016 |
The non-benzodiazepine anxiolytic drug etifoxine causes a rapid, receptor-independent stimulation of neurosteroid biosynthesis.
Topics: 17-alpha-Hydroxypregnenolone; 20-alpha-Dihydroprogesterone; Animals; Anti-Anxiety Agents; Bicuculline; Complex Mixtures; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Gene Expression; Hypothalamus; Isoquinolines; Male; Neuropeptides; Oxazines; Peptide Fragments; Pregnanolone; Progesterone; Rana esculenta; Receptors, GABA-A; Tissue Culture Techniques | 2015 |
Comparing the discriminative stimulus effects of modulators of GABAA receptors containing α4-δ subunits with those of gaboxadol in rats.
Topics: Animals; Dose-Response Relationship, Drug; Ethanol; Flumazenil; GABA Agonists; GABA Modulators; Isoxazoles; Male; Midazolam; Pregnanolone; Protein Subunits; Rats; Receptors, GABA-A | 2016 |
A theory of the anxiolytic action of flumazenil in anxiety disorders.
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Flumazenil; gamma-Aminobutyric Acid; Humans; Hypothalamo-Hypophyseal System; Pituitary-Adrenal System; Pregnanolone; Receptors, GABA-A | 2022 |