flumazenil has been researched along with pk 11195 in 82 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (18.29) | 18.7374 |
| 1990's | 43 (52.44) | 18.2507 |
| 2000's | 20 (24.39) | 29.6817 |
| 2010's | 4 (4.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Boisgard, R; Da Pozzo, E; Damont, A; Dollé, F; Kassiou, M; Kuhnast, B; Lemée, F; Martini, C; Raggiri, G; Scarf, AM; Selleri, S; Tavitian, B | 1 |
| Bendinelli, S; Castellano, S; Cosconati, S; Costa, B; Da Pozzo, E; Da Settimo, F; Greco, G; Martini, C; Milite, C; Novellino, E; Pugliesi, I; Rizzetto, E; Sbardella, G; Stefancich, G; Taliani, S | 1 |
| Byrnes, JJ; Galpern, WR; Greenblatt, DJ; Miller, LG; Shader, RI | 1 |
| Järvinen, A; Männistö, PT; Rägo, L | 1 |
| Anholt, RR; Zarbin, MA | 1 |
| Hernández, J | 1 |
| Anzini, M; Botta, M; Cagnotto, A; Cappelli, A; Vomero, S | 1 |
| De Luca, C; De Medici, D; Massotti, M | 1 |
| Elgoyhen, AB; Kazanietz, MG | 1 |
| Hernández, J; Pérez, D; Ruiz, F | 1 |
| Adler-Graschinsky, E; Elgoyhen, B | 1 |
| Bachy, A; Cordeau, LR; Croizat, BP; Gros, F; Keane, PE; Larcher, JC; Le Marquer, FJ; Vayssiere, JL | 1 |
| Albertson, TE; Joy, RM | 1 |
| Appollonio, I; Ferrarese, C; Frattola, L; Frigo, M; Gaini, SM; Piolti, R | 1 |
| Chiesi, M; Erne, P; Fulbright, J; Hermsmeyer, K; Longoni, S | 1 |
| Dubroeucq, MC; Gauthier, A; Guérémy, C; Le Fur, G; Mizoule, J; Renault, C; Uzan, A | 1 |
| Fares, F; Gavish, M | 1 |
| Bryere, P; Naquet, R; Valin, A | 1 |
| Astier, H; Roussel, JP; Tapia-Arancibia, L | 1 |
| Lafaille, F; Lal, S; Nair, NP; Quirion, R; Suranyi-Cadotte, B | 1 |
| Bender, AS; Hertz, L | 1 |
| Albertson, TE; Walby, WF | 1 |
| File, SE; Pellow, S | 1 |
| Belin, C; Carriot, T; Dubroeucq, MC; Guérémy, C; Le Fur, G; Mestre, M; Renault, C; Uzan, A | 1 |
| Kai, T; Kanaide, H; Kobayashi, S; Nishimura, J; Takahashi, S; Yoshimura, H | 1 |
| Ekström, P; Grossmann, E; Meissl, H; Yáñez, J | 1 |
| Cuparencu, B; Horák, J | 1 |
| Niles, LP; Tenn, CC | 1 |
| Antonenko, YN; Kinnally, KW; McEnery, MW; Snyder, SH; Tedeschi, H; Zorov, DB | 1 |
| Matthews, EK; Ratcliffe, SL | 1 |
| Auta, J; Costa, E; Guidotti, A; Kozikowski, A; Ma, D; Romeo, E | 1 |
| Ruggieri, MR; Smyth, RJ; Uhlman, EJ | 1 |
| Beauchemin, V; Dennis, T; Lavoie, N | 1 |
| Baron, JC; Barré, L; Derlon, JM; MacKenzie, ET; Miyazawa, H; Sette, G; Tillet, I; Travère, JM; Young, AR | 1 |
| Lichtensteiger, W; Ramseier, H; Schlumpf, M | 1 |
| Barré, L; Crouzel, C; Halldin, C; Nutt, DJ; Osman, S; Pike, VW; Shah, F; Turton, DR; Waters, SL | 1 |
| Pericić, D; Pivac, N | 1 |
| Butterworth, RF; Leong, DK; Oliva, L | 1 |
| Neu, JM; Niles, LP; Tenn, CC | 1 |
| Kulkarni, SK; Reddy, DS | 3 |
| Holtman, PH; Jing, X; Sloan, JW; Wala, EP | 1 |
| Lin, WC | 1 |
| Dagan, E; Gavish, M; Snyder, SH; Weizman, R | 1 |
| Cespuglio, R; Miachon, S | 1 |
| Cuparencu, B; Horák, A; Horák, J; Lenghel, A | 1 |
| Jing, X; Sloan, JW; Wala, EP | 3 |
| Leeuwin, RS; van Hamme, J; van Wilgenburg, H; Zeegers, A | 1 |
| Kawaguchi, M; Yamagishi, H | 1 |
| Holtman, JR; Jing, X; Milliken, B; Sloan, JW; Wala, E | 1 |
| Blanc, F; Butterworth, RF; Fabbro-Peray, P; Lavoie, J; Layrargues, GP; Mousseau, DD; Perney, P | 1 |
| Bender, AS; Norenberg, MD | 1 |
| Honma, Y; Matsuzaki, T; Namiki, A; Tsujiguchi, N; Yamakage, M | 1 |
| Leeuwin, RS; van Wilgenburg, H; Zeegers, A | 1 |
| Kulkarni, SK; Raghavendra, V | 1 |
| Holtman, JR; Jing, X; Sloan, JW; Wala, EP | 2 |
| Bitran, D; Dugan, M; Ellis, R; Foley, M; Renda, P | 1 |
| Allmann, I; Feldon, J; Gavish, M; Lehmann, J; Leschiner, S; Pryce, CR; Weizman, R | 1 |
| Gillardin, J; Poisbeau, P; Rybalchenko, V; Schlichter, R; Verleye, M | 1 |
| Kaur, G; Kulkarni, SK; Raghavendra, V | 1 |
| Cuparencu, B; Horák, A; Horák, J | 1 |
| Chugun, A; Futamura, K; Hara, Y; Kobayashi, H; Kondo, H; Nishino, T; Ooshiro, S; Temma, K | 1 |
| Abella, C; Hernandez, J; Vargas, ML | 1 |
| Agrewala, JN; Kulkarni, SK; Raghavendra, V; Singh, V | 1 |
| Kulkarni, SK; Naidu, PS; Raghavendra, V | 1 |
| Bruni, F; Ciciani, G; Costa, B; Costagli, C; Costanzo, A; Guerrini, G; Martini, C; Selleri, S | 1 |
| Fujimoto, JM; Rady, JJ | 1 |
| Fuentes, T; Galindo, A; García Estañ, J; Hernández, J; Vargas, ML | 1 |
| Biggio, G; Latrofa, A; Papi, G; Pisu, MG; Porcu, P; Serra, M; Trapani, G | 1 |
| Kawaguchi, M; Kujirai, M; Sawaki, K | 1 |
| Brück, W; Dirnagl, U; Endres, M; Gertz, K; Gietz, A; Katchanov, J; Veh, RW; Waeber, C; Winter, B | 1 |
| Dehne, MG; Engel, J; Fuchs, M; Gonter, J; Hempelmann, G; Krüll, M; Matejec, R; Menges, T; Mühling, J; Nickolaus, KA; Sablotzki, A; Welters, ID; Wolff, M | 1 |
| Homes, TP; Katsifis, A; Keller, PA; Mattner, F | 1 |
| Costentin, J; do Rego, JC; Leprince, J; Orta, MH; Tonon, MC; Vaudry, H | 1 |
| Anseloni, VC; Gold, MS | 1 |
| do Rego, JL; Vaudry, D; Vaudry, H | 1 |
| Goeders, NE; Guerin, GF; Spence, AL | 1 |
2 review(s) available for flumazenil and pk 11195
| Article | Year |
|---|---|
Behavioural actions of Ro 5-4864: a peripheral-type benzodiazepine?
Topics: Animals; Behavior, Animal; Benzodiazepinones; Binding Sites; Brain; Convulsants; Drug Interactions; Flumazenil; Humans; Isoquinolines; Kidney; Phenytoin; Picrotoxin; Pyrazoles; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1984 |
Radioligands for PET studies of central benzodiazepine receptors and PK (peripheral benzodiazepine) binding sites--current status.
Topics: Animals; Benzodiazepines; Binding Sites; Carbon Radioisotopes; Flumazenil; Fluorine Radioisotopes; Humans; Isoquinolines; Ligands; Radioisotopes; Radioligand Assay; Receptors, GABA-A; Tomography, Emission-Computed | 1993 |
80 other study(ies) available for flumazenil and pk 11195
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Synthesis of 6-[¹⁸F]fluoro-PBR28, a novel radiotracer for imaging the TSPO 18 kDa with PET.
Topics: Acetamides; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminopyridines; Animals; Corpus Striatum; Disease Models, Animal; Fluorine Radioisotopes; Ligands; Molecular Imaging; Molecular Structure; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Receptors, GABA; Stereoisomerism | 2011 |
Synthesis and biological evaluation of 4-phenylquinazoline-2-carboxamides designed as a novel class of potent ligands of the translocator protein.
Topics: Animals; Binding, Competitive; Carrier Proteins; Cell Line, Tumor; Cell Survival; Inhibitory Concentration 50; Molecular Structure; Quinazolines; Rats; Receptors, GABA-A; Structure-Activity Relationship | 2012 |
Chronic benzodiazepine administration. X. Concurrent administration of the peripheral-type benzodiazepine ligand PK11195 attenuates chronic effects of lorazepam.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Down-Regulation; Flumazenil; Isoquinolines; Ligands; Lorazepam; Male; Mice; Motor Activity; Receptors, GABA-A | 1992 |
Effects of central and peripheral type benzodiazepine ligands on thyrotropin and prolactin secretion.
Topics: Animals; Benzodiazepinones; Carbolines; Clonazepam; Cold Temperature; Diazepam; Flumazenil; Hypothalamo-Hypophyseal System; Isoquinolines; Male; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Secretory Rate; Thyrotropin; Thyrotropin-Releasing Hormone | 1992 |
Benzodiazepine receptors in the eye.
Topics: Aged; Animals; Autoradiography; Binding Sites; Eye; Flumazenil; Humans; Isoquinolines; Macaca fascicularis; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Tissue Distribution | 1991 |
The negative inotropic effect of diazepam in rat right ventricular strips.
Topics: Animals; Depression, Chemical; Diazepam; Electric Stimulation; Female; Flumazenil; Heart Ventricles; In Vitro Techniques; Isoquinolines; Male; Myocardial Contraction; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1991 |
5-HT and benzodiazepine receptor ligands. III. Synthesis and receptor affinities of 1,2,4-triazolo[4',3':1,6]pyridazino[4,5-b]quinoline and 2,3-dihydro-9-phenyl-1H-pyrrolo[3,4-b]quinoline-1-one derivatives.
Topics: Animals; Binding, Competitive; Brain; Cerebellum; Flumazenil; In Vitro Techniques; Isoquinolines; Ligands; Pyrroles; Quinolones; Rats; Receptors, GABA-A; Receptors, Serotonin | 1990 |
Relative efficacies of benzodiazepine receptor agonists in affecting red nucleus electrical activity in rabbits.
Topics: Animals; Bicuculline; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; Imidazoles; Isoquinolines; Male; Pentylenetetrazole; Pyridazines; Pyridines; Rabbits; Receptors, GABA-A; Red Nucleus; Zolpidem | 1990 |
Relaxant effect of benzodiazepines on uterine rings isolated from estrogen-treated rats.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Bicuculline; Clonazepam; Convulsants; Diazepam; Estradiol; Estrogens; Female; Flumazenil; In Vitro Techniques; Isoquinolines; Muscle, Smooth; Potassium Chloride; Propranolol; Rats; Rats, Inbred Strains; Uterine Contraction | 1990 |
The effect of diazepam on ventricular automaticity induced by a local injury. Evidence of involvement of "peripheral type" benzodiazepine receptors.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Diazepam; Diltiazem; Dose-Response Relationship, Drug; Female; Flumazenil; Heart Ventricles; Isoquinolines; Male; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Ventricular Function | 1989 |
Diminution by benzodiazepines of the chronotropic responses to noradrenaline in rat isolated atria.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Anti-Anxiety Agents; Benzodiazepinones; Clonazepam; Colforsin; Cyclic AMP; Diazepam; Female; Flumazenil; Heart; Heart Rate; In Vitro Techniques; Isoquinolines; Male; Myocardium; Norepinephrine; Rats; Rats, Inbred Strains | 1989 |
Effects of peripheral benzodiazepines upon the O2 consumption of neuroblastoma cells.
Topics: Animals; Benzodiazepines; Cells, Cultured; Clonazepam; Clone Cells; Diazepam; Flumazenil; Isoquinolines; Mice; Mitochondria; Neuroblastoma; Oxygen Consumption; Receptors, GABA-A | 1989 |
Modification of evoked hippocampal dentate inhibition by diazepam and three antagonists in urethane-anesthetized rats.
Topics: Anesthesia; Animals; Diazepam; Evoked Potentials; Flumazenil; gamma-Aminobutyric Acid; Hippocampus; Isoquinolines; Male; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synapses; Urethane | 1989 |
Benzodiazepine receptors and diazepam-binding inhibitor in human cerebral tumors.
Topics: Adolescent; Adult; Aged; Astrocytoma; Brain; Brain Neoplasms; Diazepam Binding Inhibitor; Female; Flumazenil; Glioma; Humans; Isoquinolines; Male; Middle Aged; Neuropeptides; Receptors, GABA-A | 1989 |
Relaxation of rat vascular muscle by peripheral benzodiazepine modulators.
Topics: Animals; Benzodiazepinones; Calcium; Calcium Channel Blockers; Flumazenil; Guanylate Cyclase; In Vitro Techniques; Isoquinolines; Potassium; Rats; Rats, Inbred WKY; Receptors, GABA-A; Vasodilation | 1989 |
Opposite effects of two ligands for peripheral type benzodiazepine binding sites, PK 11195 and RO5-4864, in a conflict situation in the rat.
Topics: Animals; Benzodiazepinones; Carbolines; Conditioning, Operant; Conflict, Psychological; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Flumazenil; Isoquinolines; Ligands; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1985 |
Solubilization of peripheral benzodiazepine-binding sites from rat kidney.
Topics: Animals; Benzodiazepinones; Binding, Competitive; Carbolines; Chlordiazepoxide; Clonazepam; Diazepam; Digitonin; Flumazenil; Flurazepam; Guanidine; Guanidines; Hot Temperature; Isoquinolines; Kidney; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Solubility; Time Factors; Urea | 1985 |
Convulsant effect of Ro 5-4864, a peripheral type benzodiazepine, on the baboon (Papio papio).
Topics: Animals; Benzodiazepines; Benzodiazepinones; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Isoquinolines; Papio; Receptors, GABA-A; Seizures | 1986 |
Benzodiazepines inhibit thyrotropin (TSH)-releasing hormone-induced TSH and growth hormone release from perifused rat pituitaries.
Topics: Animals; Benzodiazepines; Bicuculline; Diazepam; Flumazenil; Growth Hormone; Growth Hormone-Releasing Hormone; In Vitro Techniques; Isoquinolines; Male; Picrotoxin; Pituitary Gland, Anterior; Rats; Receptors, GABA-A; Secretory Rate; Thyrotropin; Thyrotropin-Releasing Hormone | 1986 |
Coexistence of central and peripheral benzodiazepine binding sites in the human pineal gland.
Topics: Aged; Benzodiazepinones; Binding, Competitive; Cell Membrane; Clonazepam; Female; Flumazenil; Flunitrazepam; Humans; Isoquinolines; Male; Middle Aged; Pineal Gland; Receptors, GABA-A | 1987 |
Dissimilarities between benzodiazepine-binding sites and adenosine uptake sites in astrocytes and neurons in primary cultures.
Topics: Adenosine; Animals; Astrocytes; Benzodiazepines; Binding Sites; Cells, Cultured; Diazepam; Flumazenil; Isoquinolines; Neurons; Pyrazoles; Receptors, GABA-A | 1987 |
Effects of the benzodiazepine antagonists RO 15-1788, CGS-8216 and PK-11195 on amygdaloid kindled seizures and the anticonvulsant efficacy of diazepam.
Topics: Amygdala; Animals; Diazepam; Flumazenil; Isoquinolines; Kindling, Neurologic; Male; Pyrazoles; Rats; Rats, Inbred Strains | 1986 |
Electrophysiological and pharmacological characterization of peripheral benzodiazepine receptors in a guinea pig heart preparation.
Topics: Action Potentials; Animals; Benzodiazepinones; Clonazepam; Convulsants; Diazepam; Dose-Response Relationship, Drug; Electric Stimulation; Flumazenil; Guinea Pigs; Heart; In Vitro Techniques; Isoquinolines; Myocardial Contraction; Myocardium; Receptors, Cell Surface; Receptors, GABA-A | 1984 |
Effects of midazolam on intracellular Ca2+ and tension in airway smooth muscles.
Topics: Animals; Anti-Anxiety Agents; Calcium; Drug Interactions; Flumazenil; Fluorometry; GABA Modulators; In Vitro Techniques; Intracellular Fluid; Ion Transport; Isoquinolines; Midazolam; Muscle Contraction; Muscle, Smooth; Potassium; Swine; Trachea | 1995 |
Benzodiazepines influence melatonin secretion of the pineal organ of the trout in vitro.
Topics: 5-Methoxytryptamine; Animals; Benzodiazepines; Calcium; Clonazepam; Culture Media; Dark Adaptation; Diazepam; Flumazenil; Hydroxyindoleacetic Acid; In Vitro Techniques; Indoles; Isoquinolines; Light; Magnesium; Melatonin; Oncorhynchus mykiss; Pineal Gland | 1994 |
Effects of 4'-chlordiazepam on glycemia and serum lipids in hyperlipidemic rats: interactions with PK 11195 and flumazenil.
Topics: Animals; Benzodiazepinones; Blood Glucose; Dose-Response Relationship, Drug; Drug Interactions; Flumazenil; Hypolipidemic Agents; Isoquinolines; Lipids; Male; Rats; Rats, Wistar; Receptors, GABA-A | 1995 |
Central-type benzodiazepine receptors mediate the antidopaminergic effect of clonazepam and melatonin in 6-hydroxydopamine lesioned rats: involvement of a GABAergic mechanism.
Topics: Animals; Apomorphine; Behavior, Animal; Bicuculline; Clonazepam; Corpus Striatum; Dopamine Agonists; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Isoquinolines; Male; Melatonin; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1995 |
Mitochondrial benzodiazepine receptor linked to inner membrane ion channels by nanomolar actions of ligands.
Topics: Animals; Benzodiazepinones; Clonazepam; Convulsants; Flumazenil; Intracellular Membranes; Ion Channels; Isoquinolines; Male; Membrane Potentials; Mitochondria, Heart; Protoporphyrins; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Submitochondrial Particles | 1993 |
Modification of the photodynamic action of delta-aminolaevulinic acid (ALA) on rat pancreatoma cells by mitochondrial benzodiazepine receptor ligands.
Topics: Aminolevulinic Acid; Animals; Benzodiazepines; Benzodiazepinones; Cell Division; Cell Survival; Clonazepam; Flumazenil; Isoquinolines; Ligands; Mitochondria; Oxygen; Pancreatic Neoplasms; Photochemotherapy; Protoporphyrins; Radiation-Protective Agents; Radiation-Sensitizing Agents; Rats; Receptors, GABA-A; Singlet Oxygen; Tumor Cells, Cultured | 1995 |
Participation of mitochondrial diazepam binding inhibitor receptors in the anticonflict, antineophobic and anticonvulsant action of 2-aryl-3-indoleacetamide and imidazopyridine derivatives.
Topics: Aggression; Allosteric Regulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Clonazepam; Desoxycorticosterone; Flumazenil; Imidazoles; Indoleacetic Acids; Isoniazid; Isoquinolines; Mitochondria; Phobic Disorders; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, GABA-A; Seizures; Zolpidem | 1993 |
Identification and characterization of a high-affinity peripheral-type benzodiazepine receptor in rabbit urinary bladder.
Topics: Animals; Flumazenil; Flunitrazepam; GABA-A Receptor Antagonists; Isoquinolines; Male; Muscle Contraction; Muscle, Smooth; Rabbits; Receptors, GABA-A; Urinary Bladder | 1994 |
Quantitative autoradiographic studies of the effects of bilateral olfactory bulbectomy in the rat brain: central- and peripheral-type benzodiazepine receptors.
Topics: Animals; Autoradiography; Behavior, Animal; Brain Chemistry; Flumazenil; Flunitrazepam; Isoquinolines; Male; Olfactory Bulb; Peripheral Nervous System; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1994 |
In vivo mapping of brain benzodiazepine receptor changes by positron emission tomography after focal ischemia in the anesthetized baboon.
Topics: Animals; Brain Ischemia; Brain Mapping; Cerebral Infarction; Flumazenil; Isoquinolines; Macrophages; Magnetic Resonance Imaging; Male; Neuroglia; Neurons; Oxygen Consumption; Papio; Receptors, GABA-A; Regional Blood Flow; Time Factors; Tomography, Emission-Computed; Tomography, X-Ray Computed | 1993 |
In vitro inhibition of cellular immune responses by benzodiazepines and PK 11195. Effects on mitogen- and alloantigen-driven lymphocyte proliferation and on IL-1, IL-2 synthesis and IL-2 receptor expression.
Topics: Animals; B-Lymphocytes; Benzodiazepines; Benzodiazepinones; Clonazepam; Diazepam; Female; Flumazenil; Immunity, Cellular; In Vitro Techniques; Interleukin-1; Interleukin-2; Isoquinolines; Lymphocyte Activation; Male; Mice; Mice, Inbred A; Mice, Inbred C57BL; Neuroimmunomodulation; Receptors, GABA-A; T-Lymphocytes | 1993 |
Inhibitory effect of diazepam on the activity of the hypothalamic-pituitary-adrenal axis in female rats.
Topics: Adrenocorticotropic Hormone; Animals; Bicuculline; Corticosterone; Depression, Chemical; Diazepam; Female; Flumazenil; GABA-A Receptor Antagonists; Hypothalamo-Hypophyseal System; Isoquinolines; Picrotoxin; Pituitary-Adrenal System; Rats; Receptors, GABA-A | 1993 |
Quantitative autoradiography using selective radioligands for central and peripheral-type benzodiazepine receptors in experimental Wernicke's encephalopathy: implications for positron emission tomography imaging.
Topics: Animals; Autoradiography; Brain; Brain Mapping; Disease Models, Animal; Flumazenil; GABA Modulators; Humans; Isoquinolines; Male; Neuroglia; Neurons; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Tomography, Emission-Computed; Wernicke Encephalopathy | 1996 |
PK 11195 blockade of benzodiazepine-induced inhibition of forskolin-stimulated adenylate cyclase activity in the striatum.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Benzodiazepines; Benzodiazepinones; Colforsin; Corpus Striatum; Diazepam; Drug Interactions; Flumazenil; GABA-A Receptor Antagonists; Guanosine Triphosphate; Indoles; Isoquinolines; Kinetics; Male; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Virulence Factors, Bordetella | 1996 |
Role of GABA-A and mitochondrial diazepam binding inhibitor receptors in the anti-stress activity of neurosteroids in mice.
Topics: Analysis of Variance; Animals; Ascorbic Acid; Behavior, Animal; Binding Sites; Cerebellum; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GABA Antagonists; GABA Modulators; Isoquinolines; Male; Mice; Mitochondria; Motor Activity; Pain Measurement; Picrotoxin; Progesterone; Receptors, GABA-A; RNA; Stress, Psychological; Triazolam | 1996 |
Intrathecally administered flumazenil and PK 11195 precipitate abstinence syndrome in freely moving diazepam dependent rats.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Electrodes, Implanted; Electroencephalography; Female; Flumazenil; GABA-A Receptor Antagonists; Injections, Spinal; Isoquinolines; Rats; Rats, Sprague-Dawley; Tremor | 1996 |
Stimulatory effect of diazepam on gastric acid secretion in the continuously perfused stomach in rats under urethane anesthesia.
Topics: 3-Mercaptopropionic Acid; Analysis of Variance; Anesthetics, Intravenous; Animals; Atropine; Diazepam; Flumazenil; GABA Agents; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; Gastric Acid; Gastric Mucosa; Hexamethonium; Isoquinolines; Male; Parasympatholytics; Pentylenetetrazole; Picrotoxin; Pylorus; Rats; Rats, Wistar; Receptors, GABA; Urethane; Vagotomy | 1997 |
Differential anxiolytic effects of neurosteroids in the mirrored chamber behavior test in mice.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Calcium Channel Blockers; Dose-Response Relationship, Drug; Flumazenil; GABA Antagonists; GABA Modulators; Isoquinolines; Male; Mice; Mice, Inbred BALB C; Motor Activity; Nifedipine; Picrotoxin; Reaction Time; Steroids; Triazolam | 1997 |
Impact of pregnancy and lactation on GABA(A) receptor and central-type and peripheral-type benzodiazepine receptors.
Topics: Animals; Central Nervous System; Female; Flumazenil; GABA Modulators; Isoquinolines; Lactation; Pregnancy; Pregnancy, Animal; Prolactin; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Tissue Distribution | 1997 |
Prevention of ACTH- and adrenalectomy-induced muricidal behavior: by benzodiazepinic ligands.
Topics: Adrenalectomy; Adrenocorticotropic Hormone; Aggression; Animals; Benzodiazepinones; Clonazepam; Flumazenil; GABA Modulators; Isoquinolines; Male; Mice; Muscimol; Rats; Rats, Wistar; Receptors, GABA-A; Time Factors | 1997 |
Effects of midazolam on glycemia and serum lipids in rats.
Topics: Aminophylline; Animals; Anti-Anxiety Agents; Blood Glucose; Drug Interactions; Fenofibrate; Flumazenil; GABA Modulators; Hypolipidemic Agents; Isoquinolines; Lipids; Male; Midazolam; Phosphodiesterase Inhibitors; Rats; Rats, Wistar | 1996 |
Comparison of abstinence syndromes precipitated by flumazenil and PK 11195 in female diazepam-dependent rats.
Topics: Animals; Anti-Anxiety Agents; Central Nervous System; Diazepam; Dose-Response Relationship, Drug; Drug Implants; Female; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Isoquinolines; Male; Peripheral Nervous System; Rats; Rats, Sprague-Dawley; Seizures; Sex Characteristics; Substance Withdrawal Syndrome; Substance-Related Disorders | 1997 |
Modification of cardiac actions of RO 05-4864 by PK 11195 and flumazenil in the perfused rat heart.
Topics: Animals; Benzodiazepinones; Drug Interactions; Female; Flumazenil; Heart; Isoquinolines; Myocardial Contraction; Rats; Rats, Wistar; Regional Blood Flow | 1997 |
Characterization of central- and peripheral-type benzodiazepine receptors in rat salivary glands.
Topics: Adrenal Glands; Animals; Binding, Competitive; Cerebral Cortex; Flumazenil; Isoquinolines; Kidney; Kinetics; Male; Organ Specificity; Parotid Gland; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A; Submandibular Gland; Tritium | 1998 |
Reversal of benzodiazepine inverse agonist FG 7142-induced anxiety syndrome by neurosteroids in mice.
Topics: Animals; Anxiety; Benzodiazepines; Benzodiazepinones; Carbolines; Flumazenil; GABA Antagonists; GABA-A Receptor Antagonists; Isoquinolines; Male; Maze Learning; Mice; Mice, Inbred BALB C; Motor Activity; Progesterone; Receptors, GABA-A; Steroids | 1997 |
Diazepam-treated female rats: flumazenil- and PK 11195-induced withdrawal in the hippocampus CA1.
Topics: Animals; Anti-Anxiety Agents; Body Weight; Diazepam; Dose-Response Relationship, Drug; Electroencephalography; Female; Flumazenil; GABA Modulators; Hippocampus; Isoquinolines; Microinjections; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1998 |
Plasma and CSF benzodiazepine receptor ligand concentrations in cirrhotic patients with hepatic encephalopathy: relationship to severity of encephalopathy and to pharmaceutical benzodiazepine intake.
Topics: Animals; Benzodiazepines; Binding, Competitive; Cell Fractionation; Cerebellum; Chronic Disease; Clonazepam; Diazepam; Flumazenil; GABA Modulators; Hepatic Encephalopathy; Humans; Isoquinolines; Liver Cirrhosis; Oxazepam; Radioligand Assay; Rats; Receptors, GABA-A; Tritium | 1998 |
Effect of benzodiazepines and neurosteroids on ammonia-induced swelling in cultured astrocytes.
Topics: Ammonia; Astrocytes; Atrial Natriuretic Factor; Benzodiazepines; Benzodiazepinones; Brain Edema; Cell Size; Clonazepam; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Diazepam; Diazepam Binding Inhibitor; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Isoquinolines; Nerve Tissue Proteins; Neuropeptides; Peptide Fragments; Pregnanolone; Pregnenolone; Protoporphyrins; Receptors, GABA-A; Steroids; Up-Regulation | 1998 |
Inhibitory effects of diazepam and midazolam on Ca2+ and K+ channels in canine tracheal smooth muscle cells.
Topics: Anesthetics, Intravenous; Animals; Calcium Channel Blockers; Calcium Channels; Diazepam; Dogs; Electrophysiology; Flumazenil; GABA Antagonists; GABA-A Receptor Antagonists; In Vitro Techniques; Isoquinolines; Midazolam; Muscle, Smooth; Patch-Clamp Techniques; Potassium Channel Blockers; Trachea | 1999 |
Cardiac effects of benzodiazepine receptor agonists and antagonists in the isolated rat heart: a comparative study.
Topics: Animals; Benzodiazepines; Cardiac Output; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Female; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Heart; In Vitro Techniques; Isoquinolines; Myocardial Contraction; Perfusion; Pyridines; Rats; Receptors, GABA-A; Zolpidem | 1998 |
Reversal of morphine tolerance and dependence by melatonin: possible role of central and peripheral benzodiazepine receptors.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Female; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Isoquinolines; Melatonin; Mice; Mice, Inbred BALB C; Morphine; Morphine Dependence; Narcotics; Receptors, GABA-A | 1999 |
Substantia nigra: the involvement of central and peripheral benzodiazepine receptors in physical dependence on diazepam as evidenced by behavioral and EEG effects.
Topics: Animals; Anti-Anxiety Agents; Antineoplastic Agents; Behavior, Animal; Central Nervous System; Diazepam; Dose-Response Relationship, Drug; Drug Implants; Electrodes, Implanted; Electroencephalography; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Isoquinolines; Male; Peripheral Nervous System; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Substance Withdrawal Syndrome; Substance-Related Disorders; Substantia Nigra; Weight Gain | 1999 |
Precipitated withdrawal in the substantia nigra in diazepam-dependent female rats.
Topics: Animals; Anti-Anxiety Agents; Body Weight; Diazepam; Electroencephalography; Female; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Isoquinolines; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Substance-Related Disorders; Substantia Nigra | 1999 |
Anxiolytic effects of the neuroactive steroid pregnanolone (3 alpha-OH-5 beta-pregnan-20-one) after microinjection in the dorsal hippocampus and lateral septum.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Chloride Channels; Dose-Response Relationship, Drug; Electroshock; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Hippocampus; Isoquinolines; Male; Microinjections; Picrotoxin; Pregnanolone; Rats; Rats, Long-Evans; Receptors, GABA-A; Septum of Brain | 1999 |
Peripheral benzodiazepine receptors in cerebral cortex, but not in internal organs, are increased following inescapable stress and subsequent avoidance/escape shuttle-box testing.
Topics: Adrenal Glands; Animals; Antineoplastic Agents; Avoidance Learning; Brain; Cerebral Cortex; Corticosterone; Flumazenil; GABA Modulators; Isoquinolines; Kidney; Male; Rats; Rats, Wistar; Receptors, GABA-A; Stress, Physiological; Testis | 1999 |
Pharmacokinetics of the peripheral benzodiazepine receptor antagonist, PK 11195, in rats. The effect of dose and gender.
Topics: Animals; Antineoplastic Agents; Area Under Curve; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; Injections, Intravenous; Isoquinolines; Male; Rats; Rats, Sprague-Dawley; Sex Characteristics | 2000 |
Modulation of GABAergic synaptic transmission by the non-benzodiazepine anxiolytic etifoxine.
Topics: Animals; Behavior, Animal; Bicuculline; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Dose-Response Relationship, Drug; Drinking Behavior; Flumazenil; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hypothalamus; Isoquinolines; Male; Membrane Potentials; Membranes; Neurons; Oxazines; Patch-Clamp Techniques; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, GABA-A; Sulfur Radioisotopes; Synaptic Transmission; Tetrodotoxin; Tranquilizing Agents | 2000 |
The pharmacodynamics of PK 11195 in diazepam-dependent male and female rats.
Topics: Animals; Anti-Anxiety Agents; Antineoplastic Agents; Body Weight; Brain; Diazepam; Female; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Isoquinolines; Male; Rats; Rats, Sprague-Dawley; Seizures; Sex Characteristics; Substance Withdrawal Syndrome; Substance-Related Disorders | 2000 |
Anti-depressant action of melatonin in chronic forced swimming-induced behavioral despair in mice, role of peripheral benzodiazepine receptor modulation.
Topics: Alprazolam; Analysis of Variance; Animals; Anti-Anxiety Agents; Antioxidants; Benzodiazepinones; Bicuculline; Convulsants; Depression; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Flumazenil; GABA Agents; Immobilization; Isoquinolines; Male; Melatonin; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Receptors, GABA-A; Swimming; Time Factors | 2000 |
Acute effects of zopiclone on blood glucose level and serum lipids in hyperlipidemic rats. Interactions with PK 11195 and flumazenil.
Topics: Animals; Azabicyclo Compounds; Blood Glucose; Central Nervous System; Cholesterol; Flumazenil; GABA Modulators; Hyperlipidemias; Hypnotics and Sedatives; Isoquinolines; Lipids; Male; Peripheral Nervous System; Piperazines; Polyethylene Glycols; Rats; Rats, Wistar; Receptors, GABA-A; Triglycerides | 2000 |
Negative inotropic effect of diazepam in isolated guinea pig heart.
Topics: Adjuvants, Anesthesia; Animals; Anti-Arrhythmia Agents; Calcium Channels; Depression, Chemical; Diazepam; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Modulators; Guinea Pigs; Heart; In Vitro Techniques; Isoquinolines; Male; Membrane Potentials; Myocardial Contraction; Patch-Clamp Techniques; Verapamil | 2001 |
Diazepam increases the hypothalamic-pituitary-adrenocortical (HPA) axis activity by a cyclic AMP-dependent mechanism.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Corticosterone; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Diazepam; Flumazenil; Hypothalamus; Isoquinolines; Male; Phosphodiesterase Inhibitors; Pituitary Gland; Rats; Rats, Sprague-Dawley; Rolipram; Sulfonamides | 2001 |
Melatonin enhances Th2 cell mediated immune responses: lack of sensitivity to reversal by naltrexone or benzodiazepine receptor antagonists.
Topics: Animals; Cell Line; Central Nervous System Agents; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Flumazenil; GABA-A Receptor Antagonists; Hybridomas; Immunoglobulin G; Isoquinolines; Melatonin; Mice; Mice, Inbred BALB C; Naltrexone; Narcotic Antagonists; Ovalbumin; Peripheral Nervous System Agents; Receptors, Opioid, mu; Th2 Cells | 2001 |
Reversal of reserpine-induced vacuous chewing movements in rats by melatonin: involvement of peripheral benzodiazepine receptors.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Interactions; Dyskinesia, Drug-Induced; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Isoquinolines; Male; Mastication; Melatonin; Neostriatum; Prazosin; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, GABA-A; Receptors, Melatonin; Reserpine; Tryptamines | 2001 |
2-Arylpyrazolo[1,5-a]pyrimidin-3-yl acetamides. New potent and selective peripheral benzodiazepine receptor ligands.
Topics: Acetamides; Animals; Benzodiazepinones; Binding Sites; Cerebral Cortex; Clonazepam; Flumazenil; Glioma; Intracellular Membranes; Isoquinolines; Kidney; Ligands; Magnetic Resonance Spectroscopy; Molecular Structure; Pyrazoles; Pyrimidines; Rats; Receptors, GABA-A; Structure-Activity Relationship; Thermodynamics; Tumor Cells, Cultured | 2001 |
Confluence of antianalgesic action of diverse agents through brain interleukin(1beta) in mice.
Topics: Analgesics, Opioid; Animals; Antineoplastic Agents; Brain Chemistry; Dynorphins; Flumazenil; GABA Modulators; Injections, Intraventricular; Injections, Spinal; Interleukin-1; Isoquinolines; Male; Mice; Mice, Inbred C3H; Morphine; Pain Measurement; Receptors, GABA-A | 2001 |
Synergistic interaction of diazepam with 3',5'-cyclic adenosine monophosphate-elevating agents on rat aortic rings.
Topics: Animals; Aorta, Thoracic; Colforsin; Cyclic AMP; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Female; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; In Vitro Techniques; Isoproterenol; Isoquinolines; Male; Milrinone; Muscle Relaxants, Central; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phenylephrine; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2001 |
Binding of [3H]CB 34, a selective ligand for peripheral benzodiazepine receptors, to rat brain membranes.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Female; Flumazenil; Imidazoles; Indoleacetic Acids; Isoquinolines; Ligands; Membrane Proteins; Membranes; Nordazepam; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Tritium | 2001 |
Inhibitory effect of diazepam on muscarinic receptor-stimulated inositol 1,4,5-trisphosphate production in rat parotid acinar cells.
Topics: Animals; Anticonvulsants; Calcium; Carbachol; Chlorides; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; GTP-Binding Proteins; Inositol 1,4,5-Trisphosphate; Isoquinolines; Male; Parotid Gland; Phenylephrine; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Muscarinic; Time Factors | 2002 |
Selective neuronal vulnerability following mild focal brain ischemia in the mouse.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antidotes; Antineoplastic Agents; Autoradiography; Binding Sites; Brain Ischemia; Calbindin 2; Cell Count; Cell Survival; Choline O-Acetyltransferase; Corpus Striatum; Disease Models, Animal; Excitatory Amino Acid Antagonists; Flumazenil; Functional Laterality; Immunohistochemistry; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Isoquinolines; Mice; Neurons; Parvalbumins; Phosphopyruvate Hydratase; S100 Calcium Binding Protein G; Somatostatin; Staining and Labeling; Time Factors; Tritium | 2003 |
Benzodiazepine receptor-dependent modulation of neutrophil (PMN) free amino- and alpha-keto acid profiles or immune functions.
Topics: Adult; Amino Acids; Benzodiazepinones; Cells, Cultured; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Humans; Hydrogen Peroxide; Isoquinolines; Keto Acids; Male; Midazolam; Naloxone; Neutrophils; Peroxidase; Receptors, GABA-A; Superoxides | 2005 |
Synthesis and in vitro binding of N,N-dialkyl-2-phenylindol-3-yl-glyoxylamides for the peripheral benzodiazepine binding sites.
Topics: Amides; Animals; Binding Sites; Binding, Competitive; Cerebral Cortex; Flumazenil; Glyoxylates; In Vitro Techniques; Indoles; Intracellular Membranes; Isoquinolines; Kidney; Ligands; Male; Mitochondria; Molecular Structure; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Structure-Activity Relationship | 2006 |
Pharmacological characterization of the receptor mediating the anorexigenic action of the octadecaneuropeptide: evidence for an endozepinergic tone regulating food intake.
Topics: Animals; Anorexia; Appetite; Appetite Regulation; Diazepam Binding Inhibitor; Dose-Response Relationship, Drug; Flumazenil; Food Deprivation; GABA Modulators; GABA-A Receptor Antagonists; Hypothalamus; Isoquinolines; Male; Mice; Motor Activity; Neuropeptides; Peptide Fragments; Peptides; Receptors, G-Protein-Coupled; Receptors, GABA-A; Receptors, Neuropeptide | 2007 |
Inflammation-induced shift in the valence of spinal GABA-A receptor-mediated modulation of nociception in the adult rat.
Topics: Animals; Antineoplastic Agents; Flumazenil; Freund's Adjuvant; GABA Agonists; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Hyperalgesia; Inflammation; Injections, Spinal; Isoquinolines; Male; Midazolam; Muscimol; Nociceptors; Pain Measurement; Pain Threshold; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Signal Transduction; Spinal Cord | 2008 |
The non-benzodiazepine anxiolytic drug etifoxine causes a rapid, receptor-independent stimulation of neurosteroid biosynthesis.
Topics: 17-alpha-Hydroxypregnenolone; 20-alpha-Dihydroprogesterone; Animals; Anti-Anxiety Agents; Bicuculline; Complex Mixtures; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Gene Expression; Hypothalamus; Isoquinolines; Male; Neuropeptides; Oxazines; Peptide Fragments; Pregnanolone; Progesterone; Rana esculenta; Receptors, GABA-A; Tissue Culture Techniques | 2015 |
The differential effects of alprazolam and oxazepam on methamphetamine self-administration in rats.
Topics: Alprazolam; Amphetamine-Related Disorders; Animals; Dose-Response Relationship, Drug; Flumazenil; Isoquinolines; Male; Methamphetamine; Oxazepam; Premedication; Rats; Rats, Wistar; Receptors, GABA-A; Self Administration | 2016 |