flumazenil has been researched along with picrotoxin in 83 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 39 (46.99) | 18.7374 |
| 1990's | 27 (32.53) | 18.2507 |
| 2000's | 9 (10.84) | 29.6817 |
| 2010's | 4 (4.82) | 24.3611 |
| 2020's | 4 (4.82) | 2.80 |
| Authors | Studies |
|---|---|
| Dubrovina, NI; Finkelberg, AL; Ilyutchenok, RY; Loskutova, LV | 1 |
| Dresse, A; Massotte, L; Seutin, V; Verbanck, PM | 1 |
| Agmo, A; Fernández, H | 1 |
| Engel, JA; Söderpalm, B | 1 |
| Ichihara, K; Kameyama, T; Nabeshima, T; Tohyama, K | 1 |
| Leslie, JC; Shephard, RA; Toal, L | 1 |
| Fillenz, M; Zetterström, T | 1 |
| Dragunow, M | 1 |
| Hernández, J; Pérez, D; Ruiz, F | 1 |
| Fillenz, M; Pei, Q; Zetterström, T | 1 |
| Hamilton, MS; Shephard, RA | 1 |
| Hellevuo, K; Kiianmaa, K; Korpi, ER | 1 |
| Baur, R; Peter, AB; Sigel, E; Yao, Y | 1 |
| Miller, LG; Roy, RB; Weill, CL | 1 |
| Cooper, SJ; Estall, LB | 1 |
| Chan, CY; Farb, DH | 1 |
| Spero, L | 1 |
| File, SE; Pellow, S | 3 |
| Treit, D | 1 |
| Koe, BK; Kondratas, E; Russo, LL | 1 |
| Hara, T; Kawazawa, S; Mizuki, Y; Ushijima, I; Yamada, M | 1 |
| Rastogi, SK; Ticku, MK | 1 |
| Kempner, ES; Paul, SM; Schwartz, RD; Skolnick, P; Thomas, JW | 1 |
| Jenkinson, S; Shephard, RA; Stevenson, D | 1 |
| Bourn, WM; Garrett, RL | 1 |
| DiMicco, JA; Wible, JH; Zerbe, RL | 1 |
| Simmonds, MA | 1 |
| Garcha, HS; Rose, IC; Stolerman, IP | 1 |
| Biggio, G; Corda, MG | 1 |
| Astier, H; Roussel, JP; Tapia-Arancibia, L | 1 |
| Ayhan, IH; Palaoglu, O | 1 |
| Kavaliers, M; Wiebe, JP | 1 |
| Longo, VG; Sagratella, S | 1 |
| Engel, JA; Liljequist, S | 2 |
| File, SE | 2 |
| Corda, MG; Costa, E; Guidotti, A | 1 |
| Janiszewski, W; Schwarz, M; Sontag, KH; Turski, L | 1 |
| Ashton, D | 1 |
| Jensen, LH; Petersen, EN | 1 |
| File, SE; Green, AR; Nutt, DJ; Vincent, ND | 1 |
| Dewey, WL; Glennon, RA; Young, R | 1 |
| Ramanjaneyulu, R; Ticku, MK | 1 |
| Lee, EK; Ross, RJ; Walters, JR; Waszczak, BL | 1 |
| Colwell, DD; Kavaliers, M | 1 |
| Iwasaki, T; Nakagawa, Y | 1 |
| Dubrovina, NI | 1 |
| Basile, AS; Drugan, RC; Ferland, RJ; Ha, JH | 1 |
| Abbott, FV; Franklin, KB | 1 |
| Ishima, T; Iwasaki, T; Kimura, K; Nakagawa, Y | 1 |
| Pericić, D; Pivac, N | 1 |
| Ehrenberger, K; Felix, D | 1 |
| Chen, SW; Davies, MF; Loew, GH; Rodriguez, L | 1 |
| Li, S; Pelletier, G | 1 |
| Matsumoto, K; Nguyen, MD; Nguyen, TN; Nguyen, TT; Watanabe, H; Yamasaki, K | 1 |
| Kulkarni, SK; Reddy, DS | 2 |
| Davies, PA; Hales, TG; Hanna, MC; Kirkness, EF | 1 |
| Lin, WC | 1 |
| Covey, DF; Ferrendelli, JA; Krause, JE; Rothman, SM; Tucker, JB; Weiss, DS; White, G; Williams, KL | 1 |
| Matsumoto, K; Nguyen, TT; Watanabe, H; Yamasaki, K | 1 |
| Duarte, ID; Francischi, JN; Salgado, JV; Tatsuo, MA; Yokoro, CM | 1 |
| Bitran, D; Dugan, M; Ellis, R; Foley, M; Renda, P | 1 |
| Nemmani, KV; Ramarao, P | 1 |
| Andjelković, DS; Bokonjić, DR; Obradović, DI; Savić, MM; Stojilković, MP; Ugresić, ND | 1 |
| Bell-Horner, CL; Chen, ZL; Covey, DF; Das, P; Dillon, GH; Gonzales, EB; Huang, RQ; Raut, A | 1 |
| Baur, R; Senn, M; Séquin, U; Sigel, E; Simmen, U | 1 |
| Araki, H; Gomita, Y; Hashimoto, Y; Suemaru, K | 1 |
| Jembrek, MJ; Pericić, D; Strac, DS; Vlainić, J | 1 |
| Araújo, DA; Claudino, Fde S; de Almeida, RN; de Sousa, DP; Leite, JR; Mattei, R; Nóbrega, FF | 1 |
| Kumar, A; Singh, A | 2 |
| Kumar, A; Kumar, P; Singh, A | 1 |
| Arya, J; Balakrishnan, S; Girish, C; Raj, V | 1 |
| Bispo-da-Silva, LB; da Silveira, NS; de Oliveira-Silva, GL; Lamanes, Bde F; Prado, LC | 1 |
| Allio, A; Calorio, C; Carbone, E; Franchino, C; Gavello, D; Marcantoni, A | 1 |
| Jin, Y; Li, Y; Liu, Y; Sun, F; Yang, S; Zhang, J; Zhou, J; Zhu, K | 1 |
| Gharpure, A; Hibbs, RE; Howard, RJ; Kim, JJ; Lindahl, E; Noviello, CM; Teng, J; Walsh, RM; Zhu, S; Zhuang, Y | 1 |
| Arnold, LA; Emala, CW; Perez-Zoghbi, JF; Sajorda, DR; Webb, DA; Yocum, GT | 1 |
| Adeyemi, OO; Afolayan, O; Ajayi, AM; Ben-Azu, B; Ishola, IO; James, AB; Nwose, E; Olubodun-Obadun, TG; Umukoro, S | 1 |
2 review(s) available for flumazenil and picrotoxin
| Article | Year |
|---|---|
Behavioural pharmacology of food, water and salt intake in relation to drug actions at benzodiazepine receptors.
Topics: Animals; Anti-Anxiety Agents; Appetite; Appetite Depressants; Benzodiazepines; Benzodiazepinones; Carbolines; Chlordiazepoxide; Chlorides; Choice Behavior; Diazepam; Drinking Behavior; Feeding Behavior; Flumazenil; Food Deprivation; Food Preferences; gamma-Aminobutyric Acid; Ion Channels; Midazolam; Picrotoxin; Punishment; Pyrazoles; Receptors, GABA-A; Satiation; Sodium Chloride; Species Specificity | 1985 |
Behavioural actions of Ro 5-4864: a peripheral-type benzodiazepine?
Topics: Animals; Behavior, Animal; Benzodiazepinones; Binding Sites; Brain; Convulsants; Drug Interactions; Flumazenil; Humans; Isoquinolines; Kidney; Phenytoin; Picrotoxin; Pyrazoles; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1984 |
81 other study(ies) available for flumazenil and picrotoxin
| Article | Year |
|---|---|
Neurochemical mechanisms of memory control.
Topics: Amnesia; Animals; Bicuculline; Brain; Cats; Dopamine; Evoked Potentials; Flumazenil; GABA-A Receptor Antagonists; Male; Memory; Mice; Mice, Inbred BALB C; Neurotransmitter Agents; Norepinephrine; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA-A | 1992 |
Differential effects of picrotoxin and RO 15-1788 on high and low ethanol concentrations on rat locus coeruleus in vitro.
Topics: Animals; Dose-Response Relationship, Drug; Ethanol; Flumazenil; In Vitro Techniques; Locus Coeruleus; Male; Picrotoxin; Rats; Rats, Inbred Strains | 1992 |
Benzodiazepine receptor ligands and sexual behavior in the male rat: the role of GABAergic mechanisms.
Topics: Animals; Bicuculline; Carbolines; Chlordiazepoxide; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Male; Motor Activity; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sexual Behavior, Animal | 1991 |
Involvement of the GABAA/benzodiazepine chloride ionophore receptor complex in the 5,7-DHT Induced anticonflict effect.
Topics: 5,7-Dihydroxytryptamine; Animals; Anti-Anxiety Agents; Azides; Benzodiazepines; Bicuculline; Diazepam; Drinking Behavior; Electroshock; Flumazenil; Hippocampus; Injections, Intraventricular; Limbic System; Male; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Serotonin | 1991 |
Involvement of GABAergic systems in benzodiazepine-induced impairment of passive avoidance learning in mice.
Topics: Animals; Anti-Anxiety Agents; Avoidance Learning; Bicuculline; Chlordiazepoxide; Drug Interactions; Flumazenil; GABA Antagonists; gamma-Aminobutyric Acid; Male; Memory; Mice; Mice, Inbred Strains; Muscimol; Picrotoxin | 1991 |
Effects of chlordiazepoxide and putative anxiogenics on conditioned suppression in rats.
Topics: Amino Acids; Amino Acids, Neutral; Animals; Arousal; Avoidance Learning; Bicuculline; Chlordiazepoxide; Conditioning, Classical; Dose-Response Relationship, Drug; Electroshock; Fear; Flumazenil; Male; Picrotoxin; Rats; Rats, Inbred Strains | 1991 |
Local administration of flurazepam has different effects on dopamine release in striatum and nucleus accumbens: a microdialysis study.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Carbolines; Corpus Striatum; Dialysis; Dopamine; Flumazenil; Flurazepam; In Vitro Techniques; Male; Nucleus Accumbens; Picrotoxin; Rats; Rats, Inbred Strains; Septal Nuclei | 1990 |
Adenosine receptor antagonism accounts for the seizure-prolonging effects of aminophylline.
Topics: Adenosine; Aminophylline; Amygdala; Animals; Brain; Carbolines; Diazepam; Flumazenil; Kindling, Neurologic; Male; Picrotoxin; Pyrazoles; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Purinergic; Rolipram; Seizures; Theophylline; Xanthines | 1990 |
The effect of diazepam on ventricular automaticity induced by a local injury. Evidence of involvement of "peripheral type" benzodiazepine receptors.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Diazepam; Diltiazem; Dose-Response Relationship, Drug; Female; Flumazenil; Heart Ventricles; Isoquinolines; Male; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Ventricular Function | 1989 |
Both systemic and local administration of benzodiazepine agonists inhibit the in vivo release of 5-HT from ventral hippocampus.
Topics: Animals; Benzodiazepines; Carbolines; Chromatography, High Pressure Liquid; Dialysis; Diazepam; Flumazenil; Flurazepam; Hippocampus; Hydroxyindoleacetic Acid; Ion Channels; Male; Muscimol; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Serotonin | 1989 |
Chlordiazepoxide and valproate enhancement of saline drinking by nondeprived rats: effects of bicuculline, picrotoxin and Ro15-1788.
Topics: Animals; Bicuculline; Chlordiazepoxide; Dose-Response Relationship, Drug; Drinking Behavior; Drug Combinations; Drug Interactions; Flumazenil; Male; Picrotoxin; Rats; Rats, Inbred Strains; Sodium Chloride; Valproic Acid | 1989 |
Effect of GABAergic drugs on motor impairment from ethanol, barbital and lorazepam in rat lines selected for differential sensitivity to ethanol.
Topics: Animals; Barbital; Barbiturates; Dose-Response Relationship, Drug; Ethanol; Female; Flumazenil; GABA Antagonists; gamma-Aminobutyric Acid; Isoniazid; Lorazepam; Picrotoxin; Psychomotor Performance; Rats | 1989 |
The tremorigen aflatrem is a positive allosteric modulator of the gamma-aminobutyric acidA receptor channel expressed in Xenopus oocytes.
Topics: Allosteric Regulation; Animals; Chloride Channels; Chlorides; Dose-Response Relationship, Drug; Flumazenil; gamma-Aminobutyric Acid; Indoles; Membrane Proteins; Mycotoxins; Oocytes; Pentobarbital; Picrotoxin; Receptors, GABA-A; Xenopus | 1989 |
Chronic clonazepam administration decreases gamma-aminobutyric acidA receptor function in cultured cortical neurons.
Topics: Animals; Benzodiazepines; Cells, Cultured; Cerebral Cortex; Chick Embryo; Chlorides; Clonazepam; Drug Administration Schedule; Flumazenil; Muscimol; Picrotoxin; Receptors, GABA-A; Sesterterpenes | 1989 |
Modulation of neurotransmitter action: control of the gamma-aminobutyric acid response through the benzodiazepine receptor.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Carbolines; Chick Embryo; Electric Conductivity; Flumazenil; GABA Antagonists; gamma-Aminobutyric Acid; Neurotransmitter Agents; Picrotoxin; Pyridazines; Receptors, GABA-A | 1985 |
Modulation of specific [3H]phenytoin binding by benzodiazepines.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Flumazenil; In Vitro Techniques; Male; Phenytoin; Picrotoxin; Potassium Chloride; Rats; Receptors, GABA-A; Sodium Chloride; Stimulation, Chemical; Time Factors | 1985 |
Does the benzodiazepine antagonist Ro 15-1788 reverse the actions of picrotoxin and pentylenetetrazole on social and exploratory behaviour?
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Exploratory Behavior; Flumazenil; Male; Motor Activity; Pentylenetetrazole; Picrotoxin; Rats; Social Behavior | 1985 |
Ro 15-1788, CGS 8216, picrotoxin, and pentylenetetrazol: do they antagonize anxiolytic drug effects through an anxiogenic action?
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Drug Interactions; Flumazenil; Humans; Injections, Intraperitoneal; Male; Pentylenetetrazole; Picrotoxin; Pyrazoles; Rats; Receptors, GABA-A | 1987 |
[3H]Ro 15-1788 binding to benzodiazepine receptors in mouse brain in vivo: marked enhancement by GABA agonists and other CNS drugs.
Topics: Animals; Antipsychotic Agents; Barbiturates; Brain; Buspirone; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Injections, Intravenous; Male; Mice; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Vasodilator Agents | 1987 |
Benzodiazepines increase tonic component of postdecapitation convulsions in mice.
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Decerebrate State; Flumazenil; Male; Mice; Mice, Inbred Strains; Picrotoxin; Receptors, GABA-A; Seizures | 1988 |
Involvement of a GABAergic mechanism in the anticonvulsant effect of pentobarbital against maximal electroshock-induced seizures in rats.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Bicuculline; Drug Interactions; Electroshock; Ethanol; Flumazenil; GABA Antagonists; gamma-Aminobutyric Acid; Male; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Sleep | 1985 |
Radiation inactivation studies of the benzodiazepine/gamma-aminobutyric acid/chloride ionophore receptor complex.
Topics: Animals; Barbiturates; Benzodiazepines; Benzodiazepinones; Binding Sites; Brain; Carbolines; Cell Membrane; Chlorides; Diazepam; Flumazenil; Flunitrazepam; Ionophores; Male; Molecular Weight; Muscimol; Picrotoxin; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1985 |
Effects of valproate on hyponeophagia in rats: competitive antagonism with picrotoxin and non-competitive antagonism with RO 15-1788.
Topics: Animals; Benzodiazepinones; Dose-Response Relationship, Drug; Feeding Behavior; Flumazenil; Male; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Time Factors; Valproic Acid | 1985 |
Convulsant component of a depressant benzodiazepine.
Topics: Animals; Benzodiazepinones; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1985 |
Benzodiazepine receptors modulate circulating plasma vasopressin concentration.
Topics: Animals; Arginine Vasopressin; Benzodiazepinones; Blood Pressure; Chlordiazepoxide; Flumazenil; Male; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1985 |
Antagonism of flurazepam and other effects of Ro15-1788, PK8165 and Ro5-4864 on the GABA-A receptor complex in rat cuneate nucleus.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Drug Synergism; Flumazenil; Flurazepam; In Vitro Techniques; Male; Medulla Oblongata; Muscimol; Pentobarbital; Picrotoxin; Quinolines; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1985 |
Midazolam cue in rats: effects of Ro 15-1788 and picrotoxin.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Discrimination, Psychological; Dose-Response Relationship, Drug; Flumazenil; gamma-Aminobutyric Acid; Male; Midazolam; Nicotine; Pentobarbital; Picrotoxin; Rats; Receptors, GABA-A | 1986 |
Proconflict effect of GABA receptor complex antagonists. Reversal by diazepam.
Topics: Animals; Benzodiazepinones; Bicuculline; Conflict, Psychological; Diazepam; Flumazenil; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1986 |
Benzodiazepines inhibit thyrotropin (TSH)-releasing hormone-induced TSH and growth hormone release from perifused rat pituitaries.
Topics: Animals; Benzodiazepines; Bicuculline; Diazepam; Flumazenil; Growth Hormone; Growth Hormone-Releasing Hormone; In Vitro Techniques; Isoquinolines; Male; Picrotoxin; Pituitary Gland, Anterior; Rats; Receptors, GABA-A; Secretory Rate; Thyrotropin; Thyrotropin-Releasing Hormone | 1986 |
The possible modulation of morphine analgesia by the supramolecular GABA receptor complex.
Topics: Analgesics; Animals; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Male; Mice; Morphine; Picrotoxin; Receptors, GABA-A | 1986 |
Analgesic effects of the progesterone metabolite, 3 alpha-hydroxy-5 alpha-pregnan-20-one, and possible modes of action in mice.
Topics: Analgesics; Animals; Bicuculline; Brain; Calcium Channel Blockers; Flumazenil; Injections, Intraventricular; Male; Mice; Naloxone; Picrotoxin; Progesterone | 1987 |
An EEG investigation on the role of cerebello-rubral system in the effects of diazepam and pentobarbital.
Topics: Animals; Benzodiazepinones; Cerebellum; Diazepam; Electroencephalography; Female; Flumazenil; Male; Pentobarbital; Pentylenetetrazole; Picrotoxin; Rabbits; Red Nucleus | 1985 |
The effects of GABA and benzodiazepine receptor antagonists on the anti-conflict actions of diazepam or ethanol.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Bicuculline; Conflict, Psychological; Diazepam; Dose-Response Relationship, Drug; Ethanol; Flumazenil; Male; Picrotoxin; Punishment; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1984 |
Modification of seizures elicited by the benzodiazepine Ro 5-3663--a comparison with picrotoxin.
Topics: Animals; Benzodiazepinones; Chemical Phenomena; Chemistry; Convulsants; Diazepam; Drug Synergism; Flumazenil; Male; Mice; Picrotoxin; Pyrazoles; Quinolines; Seizures | 1984 |
Specific proconvulsant action of an imidazobenzodiazepine (RO 15-1788) on isoniazid convulsions.
Topics: Animals; Benzodiazepinones; Brain; Convulsants; Drug Synergism; Flumazenil; gamma-Aminobutyric Acid; Isoniazid; Male; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Drug; Receptors, GABA-A; Receptors, Neurotransmitter; Seizures | 1982 |
Is the muscle relaxant effect of diazepam in spastic mutant rats mediated through GABA-independent benzodiazepine receptors?
Topics: Animals; Benzodiazepinones; Bicuculline; Diazepam; Electromyography; Female; Flumazenil; Male; Muscle Contraction; Muscle Relaxation; Picrotoxin; Rats; Rats, Mutant Strains; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
RO5-4864, a ligand for benzodiazepine micromolar and peripheral binding sites: antagonism and enhancement of behavioural effects.
Topics: Animals; Behavior, Animal; Benzodiazepinones; Drug Interactions; Flumazenil; Male; Motor Activity; Phenytoin; Picrotoxin; Pyrazoles; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Diazepam, pentobarbital and D-etomidate produced increases in bicuculline seizure threshold; selective antagonism by RO15-1788, picrotoxin and (+/-)-DMBB.
Topics: Animals; Barbiturates; Benzodiazepinones; Bicuculline; Diazepam; Etomidate; Flumazenil; Imidazoles; Male; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1983 |
Bidirectional effects of benzodiazepine receptor ligands against picrotoxin- and pentylenetetrazol-induced seizures.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Brain; Convulsants; Dose-Response Relationship, Drug; Flumazenil; Lorazepam; Male; Muridae; Pentylenetetrazole; Picrotoxin; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1983 |
On the convulsant action of Ro 5-4864 and the existence of a micromolar benzodiazepine binding site in rat brain.
Topics: Animals; Benzodiazepinones; Binding Sites; Brain; Convulsants; Diazepam; Electroshock; Flumazenil; Male; Mice; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1984 |
Stereoselective stimulus effects of 3-methylflunitrazepam and pentobarbital.
Topics: Animals; Benzodiazepinones; Discrimination Learning; Flumazenil; Generalization, Stimulus; Male; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Stereoisomerism | 1984 |
Reversal of the anti-conflict action of valproate by various GABA and benzodiazepine antagonists.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Bicuculline; Conflict, Psychological; Flumazenil; GABA Antagonists; Male; Motor Activity; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Valproic Acid | 1984 |
Proconvulsant action of CGS 8216.
Topics: Animals; Benzodiazepinones; Convulsants; Drug Synergism; Flumazenil; Male; Mice; Pentylenetetrazole; Picrotoxin; Pyrazoles; Seizures | 1983 |
RO5-4864 inhibits the binding of [35S]t-butylbicyclophosphorothionate to rat brain membranes.
Topics: Androstanes; Animals; Azasteroids; Benzodiazepinones; Bicuculline; Binding Sites; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Carbolines; Cell Membrane; Cerebellum; Cerebral Cortex; Dose-Response Relationship, Drug; Flumazenil; Hippocampus; Male; Picrotoxin; Radioligand Assay; Rats | 1984 |
Effects of benzodiazepines on single unit activity in the substantia nigra pars reticulata.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Bicuculline; Caffeine; Diazepam; Dose-Response Relationship, Drug; Electric Conductivity; Flumazenil; Flurazepam; Male; Neurons; Picrotoxin; Rats; Rats, Inbred Strains; Substantia Nigra; Theophylline | 1982 |
Decreased predator avoidance in parasitized mice: neuromodulatory correlates.
Topics: Animals; Anxiety; Avoidance Learning; Bicuculline; Cats; Coccidiosis; Dizocilpine Maleate; Eimeria; Flumazenil; GABA Antagonists; GABA-A Receptor Antagonists; Male; Mice; N-Methylaspartate; Naloxone; Odorants; Picrotoxin; Predatory Behavior; Receptors, GABA-A | 1995 |
Involvement of benzodiazepine/GABA-A receptor complex in ethanol-induced state-dependent learning in rats.
Topics: Animals; Avoidance Learning; Azides; Benzodiazepines; Bicuculline; Diazepam; Ethanol; Evaluation Studies as Topic; Flumazenil; Male; Muscimol; Picrotoxin; Rats; Rats, Wistar; Reaction Time; Receptors, GABA-A | 1995 |
Effect of Leu-enkephalin on the memory reactivation produced by blockade of the benzodiazepine/GABA-chloride ionophore receptor complex.
Topics: Analysis of Variance; Animals; Avoidance Learning; Bicuculline; Enkephalin, Leucine; Flumazenil; GABA-A Receptor Antagonists; Male; Memory Disorders; Mice; Mice, Inbred BALB C; Picrotoxin; Receptors, Opioid, delta | 1995 |
The protective effects of stress control may be mediated by increased brain levels of benzodiazepine receptor agonists.
Topics: Analysis of Variance; Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Convulsants; Electroshock; Escape Reaction; Flumazenil; GABA-A Receptor Agonists; Hippocampus; Male; Picrotoxin; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Sesterterpenes; Stress, Psychological; Strychnine; Sulfur Radioisotopes; Tritium | 1994 |
Pentobarbital, diazepam, and ethanol abolish the interphase diminution of pain in the formalin test: evidence for pain modulation by GABAA receptors.
Topics: Analgesics; Animals; Chloride Channels; Diazepam; Ethanol; Flumazenil; Formaldehyde; Male; Pain Measurement; Pentobarbital; Picrotoxin; Rats; Receptors, GABA-A | 1993 |
Interaction between benzodiazepine and GABA-A receptors in state-dependent learning.
Topics: Animals; Avoidance Learning; Baclofen; Bicuculline; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Male; Muscimol; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA-A; Reference Values | 1993 |
Inhibitory effect of diazepam on the activity of the hypothalamic-pituitary-adrenal axis in female rats.
Topics: Adrenocorticotropic Hormone; Animals; Bicuculline; Corticosterone; Depression, Chemical; Diazepam; Female; Flumazenil; GABA-A Receptor Antagonists; Hypothalamo-Hypophyseal System; Isoquinolines; Picrotoxin; Pituitary-Adrenal System; Rats; Receptors, GABA-A | 1993 |
Receptorpharmacological models for the therapy of labyrinthine vertigo.
Topics: Binding Sites; Ear, Inner; Flumazenil; GABA Antagonists; Humans; Neural Conduction; Neurons, Afferent; Nystagmus, Pathologic; Picrotoxin; Receptors, GABA; Vertigo | 1996 |
The hyperphagic effect of 3 alpha-hydroxylated pregnane steroids in male rats.
Topics: Animals; Anxiety; Dose-Response Relationship, Drug; Eating; Feeding Behavior; Flumazenil; GABA Antagonists; GABA Modulators; GABA-A Receptor Antagonists; Male; Picrotoxin; Pregnanes; Pregnanolone; Rats; Rats, Sprague-Dawley | 1996 |
Further studies on the mechanism of action of the endogenous benzodiazepine receptor ligand octadecaneuropeptide on gonadotropin-releasing hormone gene expression in the rat brain.
Topics: Animals; Diazepam Binding Inhibitor; Drug Synergism; Flumazenil; GABA Antagonists; GABA Modulators; Gene Expression; Gonadotropin-Releasing Hormone; Male; Muscimol; Neuropeptides; Peptide Fragments; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger | 1996 |
The possible involvement of GABAA systems in the antinarcotic effect of majonoside-R2, a major constituent of Vietnamese ginseng, in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Analysis of Variance; Animals; Convulsants; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; Ginsenosides; Male; Mice; Morphine; Pain Measurement; Picrotoxin; Pyrrolidines; Saponins | 1996 |
Role of GABA-A and mitochondrial diazepam binding inhibitor receptors in the anti-stress activity of neurosteroids in mice.
Topics: Analysis of Variance; Animals; Ascorbic Acid; Behavior, Animal; Binding Sites; Cerebellum; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GABA Antagonists; GABA Modulators; Isoquinolines; Male; Mice; Mitochondria; Motor Activity; Pain Measurement; Picrotoxin; Progesterone; Receptors, GABA-A; RNA; Stress, Psychological; Triazolam | 1996 |
Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit.
Topics: Amino Acid Sequence; Anesthetics, Intravenous; Animals; Bicuculline; Brain; Cell Line; Consensus Sequence; DNA, Complementary; Flumazenil; Flunitrazepam; GABA Agents; gamma-Aminobutyric Acid; Humans; Molecular Sequence Data; Muscimol; Pentobarbital; Picrotoxin; Pregnanolone; Propofol; Rats; Receptors, GABA-A; Recombinant Proteins; RNA, Messenger; Transfection | 1997 |
Stimulatory effect of diazepam on gastric acid secretion in the continuously perfused stomach in rats under urethane anesthesia.
Topics: 3-Mercaptopropionic Acid; Analysis of Variance; Anesthetics, Intravenous; Animals; Atropine; Diazepam; Flumazenil; GABA Agents; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; Gastric Acid; Gastric Mucosa; Hexamethonium; Isoquinolines; Male; Parasympatholytics; Pentylenetetrazole; Picrotoxin; Pylorus; Rats; Rats, Wistar; Receptors, GABA; Urethane; Vagotomy | 1997 |
Differential anxiolytic effects of neurosteroids in the mirrored chamber behavior test in mice.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Calcium Channel Blockers; Dose-Response Relationship, Drug; Flumazenil; GABA Antagonists; GABA Modulators; Isoquinolines; Male; Mice; Mice, Inbred BALB C; Motor Activity; Nifedipine; Picrotoxin; Reaction Time; Steroids; Triazolam | 1997 |
Lactone modulation of the gamma-aminobutyric acid A receptor: evidence for a positive modulatory site.
Topics: 4-Butyrolactone; Animals; Chlordiazepoxide; Female; Flumazenil; gamma-Aminobutyric Acid; Lactones; Phenobarbital; Picrotoxin; Receptors, GABA-A; Xenopus laevis | 1997 |
Involvement of supraspinal GABA receptors in majonoside-R2 suppression of clonidine-induced antinociception in mice.
Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Clonidine; Flumazenil; GABA Antagonists; GABA Modulators; Ginsenosides; Idazoxan; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Male; Mice; Pain Measurement; Picrotoxin; Receptors, GABA-A; Saponins; Spinal Cord | 1997 |
Midazolam-induced hyperalgesia in rats: modulation via GABA(A) receptors at supraspinal level.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Central Nervous System Depressants; Dose-Response Relationship, Drug; Drug Combinations; Ethanol; Flumazenil; GABA Antagonists; GABA Modulators; Hyperalgesia; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Midazolam; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA-A | 1999 |
Anxiolytic effects of the neuroactive steroid pregnanolone (3 alpha-OH-5 beta-pregnan-20-one) after microinjection in the dorsal hippocampus and lateral septum.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Chloride Channels; Dose-Response Relationship, Drug; Electroshock; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Hippocampus; Isoquinolines; Male; Microinjections; Picrotoxin; Pregnanolone; Rats; Rats, Long-Evans; Receptors, GABA-A; Septum of Brain | 1999 |
Role of benzodiazepine-GABAA receptor complex in attenuation of U-50,488H-induced analgesia and inhibition of tolerance to its analgesia by ginseng total saponin in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Bicuculline; Diazepam; Dose-Response Relationship, Drug; Drug Antagonism; Drug Tolerance; Drugs, Chinese Herbal; Flumazenil; Ginsenosides; Injections, Intraperitoneal; Male; Mice; Pain; Pain Threshold; Panax; Picrotoxin; Receptors, GABA-A; Receptors, Opioid, kappa; Saponins; Tail | 2002 |
Gaba-benzodiazepine receptor complex in brain oxidative metabolism regulation.
Topics: Animals; Diazepam; Flumazenil; Frontal Lobe; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Male; Oxygen Consumption; Picrotoxin; Rats; Rats, Wistar | 2002 |
Inhibition of type A GABA receptors by L-type calcium channel blockers.
Topics: 4-Butyrolactone; Animals; Benzodiazepines; Binding Sites; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Dihydropyridines; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Humans; Hypothalamus; Kidney; Mutagenesis, Site-Directed; Nitrendipine; Picrotoxin; Protein Structure, Tertiary; Rats; Receptors, GABA-A; Recombinant Proteins; Solvents; Species Specificity; Zinc | 2004 |
Novel plant substances acting as beta subunit isoform-selective positive allosteric modulators of GABAA receptors.
Topics: Allosteric Regulation; Animals; Araliaceae; Bicuculline; Flumazenil; Flunitrazepam; GABA Modulators; Picrotoxin; Plant Extracts; Receptors, GABA-A; Xenopus laevis | 2005 |
Effects of drugs acting on the GABA-benzodiazepine receptor complex on flurothyl-induced seizures in Mongolian gerbils.
Topics: Amino Acids; Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Ethanol; Flumazenil; Flurothyl; GABA Antagonists; GABA-A Receptor Antagonists; Gerbillinae; Male; Picrotoxin; Receptors, GABA-A; Seizures; Valproic Acid | 2006 |
Allosteric uncoupling and up-regulation of benzodiazepine and GABA recognition sites following chronic diazepam treatment of HEK 293 cells stably transfected with alpha1beta2gamma2S subunits of GABA (A) receptors.
Topics: Allosteric Regulation; Animals; Benzodiazepines; Binding Sites; Binding, Competitive; Cell Line; Diazepam; Flumazenil; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Muscimol; Picrotoxin; Protein Subunits; Pyridazines; Radioligand Assay; Rats; Receptors, GABA-A; Receptors, GABA-B; Transfection; Up-Regulation | 2007 |
Anticonvulsant effect of a natural compound alpha,beta-epoxy-carvone and its action on the nerve excitability.
Topics: Action Potentials; Animals; Anticonvulsants; Convulsants; Cyclohexane Monoterpenes; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Epilepsy; Flumazenil; GABA Modulators; In Vitro Techniques; Male; Mice; Monoterpenes; Pentylenetetrazole; Physical Stimulation; Picrotoxin; Rats; Rats, Wistar; Sciatic Nerve | 2008 |
Possible GABAergic modulation in the protective effect of allopregnanolone on sleep deprivation-induced anxiety-like behavior and oxidative damage in mice.
Topics: Animals; Anxiety; Behavior, Animal; Body Weight; Catalase; Dose-Response Relationship, Drug; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; Glutathione; Lipid Peroxidation; Male; Maze Learning; Mice; Motor Activity; Muscimol; Neuroprotective Agents; Nitrites; Oxidative Stress; Picrotoxin; Pregnanolone; Sleep Deprivation | 2008 |
Possible involvement of GABAergic mechanism in protective effect of melatonin against sleep deprivation-induced behaviour modification and oxidative damage in mice.
Topics: Animals; Antioxidants; Anxiety; Behavior, Animal; Body Weight; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; Lipid Peroxidation; Male; Maze Learning; Melatonin; Mice; Motor Activity; Muscimol; Oxidative Stress; Picrotoxin; Sleep Deprivation | 2009 |
Possible involvement of GABAergic mechanism in protective effect of melatonin against sleep deprivation-induced behavior modification and oxidative damage in mice.
Topics: Animals; Antioxidants; Anxiety; Behavior, Animal; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Lipid Peroxidation; Male; Melatonin; Mice; Motor Activity; Muscimol; Oxidative Stress; Picrotoxin; Sleep Deprivation | 2011 |
Involvement of the GABAergic system in the anxiolytic-like effect of the flavonoid ellagic acid in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Dose-Response Relationship, Drug; Ellagic Acid; Flumazenil; GABA-A Receptor Antagonists; Male; Mice; Motor Activity; Picrotoxin; Receptors, GABA-A | 2013 |
The aversive, anxiolytic-like, and verapamil-sensitive psychostimulant effects of pulegone.
Topics: Animals; Anti-Anxiety Agents; Central Nervous System Stimulants; Choice Behavior; Conditioning, Psychological; Cyclohexane Monoterpenes; Diltiazem; Drug Interactions; Flumazenil; Grooming; Haloperidol; Hand Strength; Male; Maze Learning; Menthol; Mice; Monoterpenes; Motor Activity; Picrotoxin; Reinforcement, Psychology; Rotarod Performance Test; Verapamil | 2014 |
Bud extracts from Tilia tomentosa Moench inhibit hippocampal neuronal firing through GABAA and benzodiazepine receptors activation.
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Dose-Response Relationship, Drug; Flumazenil; gamma-Aminobutyric Acid; Hippocampus; Hypnotics and Sedatives; Mice; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Picrotoxin; Plant Extracts; Receptors, GABA-A; Tilia | 2015 |
Gelsedine-type alkaloids: Discovery of natural neurotoxins presented in toxic honey.
Topics: Animals; Antidotes; Biological Availability; Female; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Glucuronides; Honey; Hydroxylation; Indole Alkaloids; Lethal Dose 50; Male; Mice, Inbred ICR; Neurotoxins; Picrotoxin; Rats, Sprague-Dawley | 2020 |
Shared structural mechanisms of general anaesthetics and benzodiazepines.
Topics: Allosteric Regulation; Anesthetics, General; Barbiturates; Benzodiazepines; Bicuculline; Binding Sites; Binding, Competitive; Cryoelectron Microscopy; Diazepam; Electrophysiology; Etomidate; Flumazenil; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Ligands; Models, Molecular; Molecular Conformation; Molecular Dynamics Simulation; Phenobarbital; Picrotoxin; Propofol; Receptors, GABA-A | 2020 |
Imidazobenzodiazepine PI320 Relaxes Mouse Peripheral Airways by Inhibiting Calcium Mobilization.
Topics: Animals; Asthma; Calcium; Calcium Signaling; Flumazenil; gamma-Aminobutyric Acid; Inositol; Ligands; Lung; Methacholine Chloride; Mice; Muscle Contraction; Muscle, Smooth; Picrotoxin | 2022 |
Probable mechanisms involved in the antiepileptic activity of Clerodendrum polycephalum Baker (Labiatae) leaf extract in mice exposed to chemical-induced seizures.
Topics: Animals; Anticonvulsants; Antioxidants; Arginine; Clerodendrum; Cyclooxygenase 2; Flumazenil; Guanosine Monophosphate; Kainic Acid; Lamiaceae; Methylene Blue; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type I; Pentylenetetrazole; Picrotoxin; Plant Extracts; Receptors, GABA-A; Seizures; Soluble Guanylyl Cyclase; Spasm | 2022 |