flumazenil and phenytoin

flumazenil has been researched along with phenytoin in 19 studies

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19907 (36.84)18.7374
1990's1 (5.26)18.2507
2000's4 (21.05)29.6817
2010's7 (36.84)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Topliss, JG; Yoshida, F1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL1
Backus, KH; Pflimlin, P; Trube, G1
Spero, L1
Chweh, AY; Swinyard, EA; Wolf, HH1
Kulkarni, SK; Kunchandy, J1
Teo, WL; Wong, PT1
File, SE; Pellow, S2
Abubakar, MS; Anuka, JA; Hussaini, IM; Ya'u, J; Yaro, AH1

Reviews

2 review(s) available for flumazenil and phenytoin

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Behavioural actions of Ro 5-4864: a peripheral-type benzodiazepine?
    Life sciences, 1984, Jul-16, Volume: 35, Issue:3

    Topics: Animals; Behavior, Animal; Benzodiazepinones; Binding Sites; Brain; Convulsants; Drug Interactions; Flumazenil; Humans; Isoquinolines; Kidney; Phenytoin; Picrotoxin; Pyrazoles; Rats; Receptors, Cell Surface; Receptors, GABA-A

1984

Other Studies

17 other study(ies) available for flumazenil and phenytoin

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat

2016
Action of diazepam on the voltage-dependent Na+ current. Comparison with the effects of phenytoin, carbamazepine, lidocaine and flumazenil.
    Brain research, 1991, May-10, Volume: 548, Issue:1-2

    Topics: Action Potentials; Animals; Carbamazepine; Cell Line; Cells, Cultured; Diazepam; Embryo, Mammalian; Flumazenil; Kinetics; Lidocaine; Mice; Neuroblastoma; Neurons; Phenytoin; Sodium Channels; Spinal Cord

1991
Modulation of specific [3H]phenytoin binding by benzodiazepines.
    Neurochemical research, 1985, Volume: 10, Issue:6

    Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Flumazenil; In Vitro Techniques; Male; Phenytoin; Picrotoxin; Potassium Chloride; Rats; Receptors, GABA-A; Sodium Chloride; Stimulation, Chemical; Time Factors

1985
Benzodiazepine receptors are not involved in the neurotoxicity and anti-electroshock activity of phenytoin in mice.
    Neuroscience letters, 1985, Jun-24, Volume: 57, Issue:3

    Topics: Animals; Benzodiazepinones; Clonazepam; Drug Interactions; Electroshock; Flumazenil; Male; Mice; Phenytoin; Receptors, GABA-A; Seizures

1985
Naloxone-sensitive and GABAA receptor mediated analgesic response of benzodiazepines in mice.
    Methods and findings in experimental and clinical pharmacology, 1987, Volume: 9, Issue:2

    Topics: Analgesics; Animals; Benzodiazepines; Benzodiazepinones; Bicuculline; Female; Flumazenil; Male; Mice; Naloxone; Phenytoin; Reaction Time; Receptors, GABA-A

1987
Diazepam-sensitive specific binding of phenytoin in rat brain.
    Journal of receptor research, 1986, Volume: 6, Issue:3-4

    Topics: Animals; Benzodiazepinones; Binding Sites; Cell Membrane; Cerebral Cortex; Clonazepam; Diazepam; Flumazenil; Male; Phenytoin; Rats; Rats, Inbred Strains

1986
RO5-4864, a ligand for benzodiazepine micromolar and peripheral binding sites: antagonism and enhancement of behavioural effects.
    Psychopharmacology, 1983, Volume: 80, Issue:2

    Topics: Animals; Behavior, Animal; Benzodiazepinones; Drug Interactions; Flumazenil; Male; Motor Activity; Phenytoin; Picrotoxin; Pyrazoles; Rats; Receptors, Cell Surface; Receptors, GABA-A

1983
Anticonvulsant activity of Carissa edulis (Vahl) (Apocynaceae) root bark extract.
    Journal of ethnopharmacology, 2008, Nov-20, Volume: 120, Issue:2

    Topics: Administration, Oral; Animals; Anticonvulsants; Apocynaceae; Chickens; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Flumazenil; Injections, Intraperitoneal; Lethal Dose 50; Male; Mice; Naloxone; Phenytoin; Plant Bark; Plant Extracts; Plant Roots; Seizures; Toxicity Tests, Acute

2008