flumazenil has been researched along with pentylenetetrazole in 112 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 38 (33.93) | 18.7374 |
| 1990's | 33 (29.46) | 18.2507 |
| 2000's | 23 (20.54) | 29.6817 |
| 2010's | 14 (12.50) | 24.3611 |
| 2020's | 4 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Brouillet, E; Chavoix, C; de la Sayette, V; Dodd, RH; Fournier, D; Guibert, B; Hantraye, P; Kunimoto, M; Naquet, R; Varastet, M | 1 |
| Davies, MF; Loew, GH; Maguire, PA; Onaivi, ES; Tsai, NF | 1 |
| Emmett-Oglesby, MW; Rowan, GA | 1 |
| Mehta, AK; Mhatre, M; Ticku, MK | 1 |
| Boone, MS; Emmett-Oglesby, MW; Pugh, SL | 1 |
| Commissaris, RL; Fontana, DJ; Hill, TJ; McCloskey, TC | 1 |
| Bottlaender, M; Brouillet, E; Chavoix, C; Dodd, RH; Fournier, D; Hantraye, P; Khalili-Varasteh, M; Mazière, M | 1 |
| Costa, E; Giusti, P; Guidetti, G; Guidotti, A | 1 |
| Fukuda, N; Wada, T | 2 |
| De Luca, C; De Medici, D; Massotti, M | 1 |
| Danchev, N; Georgieva, J | 1 |
| Hill, JL; Insel, TR; Mayor, RB | 1 |
| Alpern, HP; McIntyre, TD | 1 |
| Emmett-Oglesby, MW; Mathis, DA | 1 |
| Deutsch, SI; Kook, KA; Paul, SM; Vocci, F; Weizman, A; Weizman, R | 1 |
| Antelman, SM; Edwards, DJ; Knopf, S; Kocan, D | 1 |
| Kumasaka, Y; Ueki, S; Yamamoto, T | 1 |
| Brouillet, E; Chavoix, C; Crouzel, M; Fukuda, H; Guibert, B; Hantraye, P; Maziere, M; Naquet, R; Prenant, C | 1 |
| Brouillet, E; Chavoix, C; De la Sayette, V; Fournier, D; Fukuda, H; Guibert, B; Hantraye, P; Mazière, M; Naquet, R | 1 |
| Nagatani, T; Sugihara, T; Ueki, S; Yamamoto, T | 1 |
| Leidenheimer, NJ; Schechter, MD | 1 |
| Gerhardt, S; Liebman, JM | 1 |
| Harris, C; Lal, H | 1 |
| File, SE; Pellow, S | 1 |
| Treit, D | 1 |
| Biziere, K; Keane, PE; Morre, M; Simiand, J | 1 |
| Bourn, WM; Garrett, RL | 1 |
| Biggio, G; Corda, MG | 1 |
| Kulkarni, SK; Kunchandy, J | 1 |
| Jensen, LH; Petersen, EN | 2 |
| Katzman, NJ; Shannon, HE | 1 |
| Criado, JR; Harland, RD; Holloway, FA; Holohean, AM; Hunter, GA; Michaelis, RC | 1 |
| Emmett-Oglesby, MW; Harris, CM; Idemudia, SO; Lal, H; Mathis, DA | 1 |
| Longo, VG; Sagratella, S | 1 |
| Baldino, F; Geller, HM; Krespan, B | 1 |
| Gherezghiher, T; Lal, H | 1 |
| Cavalheiro, E; Chapouthier, G; Dodd, RH; Kaijima, M; Potier, P; Prado de Carvalho, L; Rossier, J; Valin, A; Venault, P | 1 |
| Bonetti, EP; Cumin, R; Gamzu, ER; Haefely, W; Müller, RK; Pieri, L; Pieri, M; Schaffner, R | 1 |
| File, SE; Green, AR; Nutt, DJ; Vincent, ND | 1 |
| File, SE | 2 |
| Chapouthier, G; de Carvalho, LP; Grecksch, G; Rossier, J; Venault, P | 1 |
| Elmesallamy, F; Emmett-Oglesby, M; Lal, H; Lewis, M; Spencer, D | 1 |
| Kaijima, M; Le Gal La Salle, G; Rossier, J | 1 |
| Coleman, JB; Cox, C; Schuler, R; Wood, RW | 1 |
| Emmett-Oglesby, MW; Lal, H; Lewis, MW; Spencer, DG | 1 |
| Cavalheiro, EA; Chapouthier, G; Dodd, RH; Grecksch, G; Prado de Carvalho, L; Rossier, J | 1 |
| Dantzer, R; Pério, A | 1 |
| Miczek, KA; Vivian, JA; Weerts, EM | 1 |
| Gruber, L; Maksay, G; Molnár, P | 1 |
| Chen, SW; Davies, MF; Loew, GH; Maguire, PA; Onaivi, ES; Tsai, NF | 1 |
| Byrnes, JJ; Greenblatt, DJ; Miller, LG; Shader, RI | 1 |
| Haefely, WE; Jenck, F; Martin, JR; Moreau, JL; Schoch, P | 1 |
| Hönack, D; Löscher, W | 1 |
| Morel, E; Perrault, G; Sanger, DJ; Zivkovic, B | 1 |
| Kapetanovic, IM; Kupferberg, HJ; Torchin, CD | 1 |
| Melchior, CL; Ritzmann, RF | 1 |
| Emmett-Oglesby, MW; Hooper, ML; Lal, H; Lane, JD; Lytle, DA; Prather, PL; Rezazadeh, SM; Rowan, GA | 1 |
| Biggio, G; Cuccheddu, T; Floris, S; Ghiani, CA; Giusti, P; Motzo, C; Serra, M | 1 |
| Chimirri, A; DeSarro, A; DeSarro, GB; Grasso, S; Zappalà, M | 1 |
| Kubová, H; Mares, P; Rathouská, J; Vorlícek, J | 1 |
| Hansen, HC; Jackson, HC; Judge, ME; Klitgaard, H; Kristiansen, M; Suzdak, PD; Swedberg, MD | 1 |
| Bottlaender, M; Brouillet, E; Fournier, D; Fuseau, C; Mazière, M; Schmid, L | 1 |
| Lin, WC | 1 |
| Chimirri, A; De Sarro, A; De Sarro, G; Giusti, P; McKernan, R; Quirk, K | 1 |
| Gobert, J; Klitgaard, H; Matagne, A; Wülfert, E | 1 |
| Chiu, TH; Li, M; Rosenberg, HC; Walsh, LA; Zhao, TJ | 1 |
| Chen, S; Kometiani, P; Lilly, SM; Rosenberg, HC; Tietz, EI; Zeng, XJ | 1 |
| Gommans, J; Hijzen, TH; Maes, RA; Olivier, B | 1 |
| Costentin, J; Garcia de Mateos-Verchere, J; Leprince, J; Tonon, MC; Vaudry, H | 1 |
| Atack, JR; Cook, SM; File, SE; Hutson, PH | 1 |
| Brown, SD; Skeen, GA; White, HS; Wolf, HH; Woodhead, JH | 1 |
| Nogueira, E; Vassilieff, VS | 1 |
| Depoortere, R; Jung, ME; Oglesby, MW | 1 |
| Hamann, M; Richter, A | 1 |
| Groenink, L; Maes, RA; Olivier, B; Oosting, RS; Pattij, T; van der Gugten, J | 1 |
| Gatch, MB; Jung, ME; Lal, H; Wallis, CJ | 1 |
| Carter, AR; Cheo-Isaacs, CT; Crooke, JJ; DeLuca, S; DeVine, A; Dubinsky, B; Hochman, C; Jordan, AD; Reitz, AB; Rosenthal, DI; Shank, RP; Vaidya, AH | 1 |
| Hansen, SL; Sánchez, C; Sperling, BB | 1 |
| Hosseinzadeh, H; Parvardeh, S | 1 |
| Löscher, W; Potschka, H; Rieck, S; Rundfeldt, C; Tipold, A | 1 |
| Hosseinzadeh, H; Mansouri, MT; Nassiri-Asl, M; Parvardeh, S | 1 |
| Ahadian, A; Faizi, M; Khojastehpoor, HR; Shafaghi, B; Shafiee, A; Tabatabai, SA; Zanganeh, V; Zarghi, A | 1 |
| Atack, JR; Bristow, L; Bromidge, F; Carling, R; Castro, JL; Cook, SM; Dawson, GR; Kerby, J; McKernan, RM; Melillo, D; Pike, A; Ragan, I; Sohal, B; Street, L; Sur, C; Tye, SJ; Wafford, KA; Whiting, P | 1 |
| Fidecka, S; Listos, J; Malec, D | 1 |
| Atack, JR; Bayley, PJ; Dawson, GR; Fletcher, SR; McKernan, RM; Wafford, KA | 1 |
| Nassiri-Asl, M; Shariati-Rad, S; Zamansoltani, F | 2 |
| Araújo, DA; Claudino, Fde S; de Almeida, RN; de Sousa, DP; Leite, JR; Mattei, R; Nóbrega, FF | 1 |
| Assreuy, AM; Bezerra, EH; Cavada, BS; de Sousa, FC; Lima, SR; Lobato, Rde F; Patrocínio, MC; Santi-Gadelha, T; Soares, PM; Vasconcelos, GS; Vasconcelos, SM | 1 |
| de Aquino Neto, MR; de Lavor, EP; de Sousa, DP; de Sousa, FC; de Sousa, HL; de Vasconcelos, PF; Macêdo, DS; Moura, BA; Silva, MA; Silva, MI; Vasconcelos, SM | 1 |
| de Carvalho, RS; de Lima, TC; Duarte, FS | 1 |
| France, CP; Gerak, LR | 1 |
| Chebib, M; Gavande, N; Hanrahan, JR; Johnston, GA; Karim, N; Wellendorph, P | 1 |
| Abbasi, E; Nassiri-Asl, M; Shafeei, M; Sheikhi, M | 1 |
| Cui, R; Li, B; Li, Y; Liu, L; Song, Y; Tang, F; Wang, L; Wang, Y; Zhao, J; Zhou, Y | 1 |
| Almeida, RN; de Sousa, DP; Leal-Cardoso, JH; Masson, CJ; Mello, CF; Nascimento, TS; Nóbrega, FF; Salvadori, MG | 1 |
| Asadi-Shekaari, M; Eslami, A; Joukar, S; Kalantaripour, T | 1 |
| Chen, CR; Chen, CY; Wei, XD | 1 |
| Mehrzadi, S; Motevalian, M; Pur, SA; Shojaii, A | 1 |
| Erfanparast, A; Henareh-Chareh, F; Tamaddonfard, E | 1 |
| Baldisserotto, B; Garlet, QI; Heinzmann, BM; Marafiga, JR; Mello, CF; Milanesi, LH; Pires, LDC | 1 |
| Josiane Ojong, L; Jules Fifen, J; Kameni Njapdounke, JS; Kavaye Kandeda, A; Ngo Bum, E; Nkamguie Nkantchoua, GC; Sotoing Taiwe, G | 1 |
| Alba-Betancourt, C; Alonso-Castro, AJ; Gasca-Martínez, D; Pérez-Gutiérrez, S; Rocha-González, E; Ruiz-Arredondo, A; Zapata-Morales, JR | 1 |
| Arabi, M; Bijad, E; Kazemi, S; Lorigooini, Z; Mahmoudi, T; Rabiei, Z; Rafieian-Kopaei, M | 1 |
| Hacke, ACM; Marques, JA; Miyoshi, E; Pereira, RP | 1 |
| Adeyemi, OO; Afolayan, O; Ajayi, AM; Ben-Azu, B; Ishola, IO; James, AB; Nwose, E; Olubodun-Obadun, TG; Umukoro, S | 1 |
| Arabi, M; Fatahinezhad, N; Lorigooini, Z; Rabiei, Z; Rafieian-Kopaei, M; Sheykhshabani, SK | 1 |
1 review(s) available for flumazenil and pentylenetetrazole
| Article | Year |
|---|---|
Drug discrimination used to study drug withdrawal.
Topics: Animals; Chlordiazepoxide; Discrimination Learning; Flumazenil; Pentylenetetrazole; Substance Withdrawal Syndrome | 1991 |
111 other study(ies) available for flumazenil and pentylenetetrazole
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
In vivo interactions of pentylenetetrazole with benzodiazepine receptors: lack of direct correlation between benzodiazepine receptor occupancy and convulsant potency of this drug.
Topics: Animals; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Electroencephalography; Flumazenil; Male; Papio; Pentylenetetrazole; Receptors, GABA-A; Seizures; Status Epilepticus; Tomography, Emission-Computed | 1992 |
Comparison of behavioral and central BDZ binding profile in three rat lines.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Behavior, Animal; Binding, Competitive; Body Temperature; Eating; Flumazenil; Flunitrazepam; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, GABA-A; Species Specificity | 1992 |
Modulation of GABAergic transmission by ethanol.
Topics: Animals; Anticonvulsants; Azides; Benzodiazepines; Brain Chemistry; Ethanol; Female; Flumazenil; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Ion Channels; Male; Mice; Mice, Inbred C57BL; Pentylenetetrazole; Rats; Rats, Inbred Strains; RNA, Messenger; Seizures; Synaptic Transmission | 1992 |
Tolerance, cross-tolerance and withdrawal in rats made dependent on diazepam.
Topics: Animals; Chlordiazepoxide; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Drug Tolerance; Flumazenil; Male; Midazolam; Pentylenetetrazole; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
beta-Carboline and pentylenetetrazol effects on conflict behavior in the rat.
Topics: Animals; Anxiety; Behavior, Animal; Carbolines; Conflict, Psychological; Dose-Response Relationship, Drug; Drinking; Electroshock; Female; Flumazenil; Pentylenetetrazole; Punishment; Rats; Rats, Inbred Strains | 1992 |
In vivo bidirectional modulatory effect of benzodiazepine receptor ligands on GABAergic transmission evaluated by positron emission tomography in non-human primates.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Carbolines; Cerebral Cortex; Diazepam; Electroencephalography; Flumazenil; gamma-Aminobutyric Acid; Ligands; Male; Papio; Pentylenetetrazole; Receptors, GABA-A; Seizures; Synaptic Transmission; Tomography, Emission-Computed | 1991 |
The preferential antagonism of pentylenetetrazole proconflict responses differentiates a class of anxiolytic benzodiazepines with potential antipanic action.
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Ataxia; Behavior, Animal; Conflict, Psychological; Flumazenil; GABA Antagonists; Hypnotics and Sedatives; Male; Motor Activity; Panic; Pentylenetetrazole; Pyridines; Rats; Rats, Inbred Strains | 1991 |
Effects of DN-2327, a new anxiolytic, diazepam and buspirone on exploratory activity of the rat in an elevated plus-maze.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Buspirone; Conflict, Psychological; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Exploratory Behavior; Flumazenil; Isoindoles; Male; Naphthyridines; Pentylenetetrazole; Rats; Rats, Inbred Strains; Spiro Compounds; Yohimbine | 1991 |
Relative efficacies of benzodiazepine receptor agonists in affecting red nucleus electrical activity in rabbits.
Topics: Animals; Bicuculline; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; Imidazoles; Isoquinolines; Male; Pentylenetetrazole; Pyridazines; Pyridines; Rabbits; Receptors, GABA-A; Red Nucleus; Zolpidem | 1990 |
The effects of the diterpene sclareol glycol on seizures do not depend on central benzodiazepine receptors.
Topics: Animals; Diterpenes; Flumazenil; Hippocampus; In Vitro Techniques; Male; Mice; Pentylenetetrazole; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1990 |
Rat pup ultrasonic isolation calls: possible mediation by the benzodiazepine receptor complex.
Topics: Animals; Benzodiazepinones; Chlorides; Diazepam; Flumazenil; Ion Channels; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sex Factors; Temperature; Vocalization, Animal | 1986 |
Patterns of convulsive susceptibility in the long-sleep and short-sleep selected mouse lines.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Female; Flumazenil; Male; Mice; Pentylenetetrazole; Phenobarbital; Reaction Time; Seizures; Sleep | 1989 |
Withdrawal from benzodiazepine dependence as a discriminative stimulus.
Topics: Animals; Chlordiazepoxide; Cocaine; Discrimination Learning; Flumazenil; Pentylenetetrazole; Rats; Substance Withdrawal Syndrome | 1989 |
Repeated swim stress alters brain benzodiazepine receptors measured in vivo.
Topics: Animals; Brain; Cerebrovascular Circulation; Clonazepam; Flumazenil; Male; Mice; Pentylenetetrazole; Receptors, GABA-A; Seizures; Stress, Physiological; Swimming; Tritium | 1989 |
Anticonvulsant and other effects of diazepam grow with time after a single treatment.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Anticonvulsants; Antipsychotic Agents; Blepharoptosis; Brain Chemistry; Catalepsy; Diazepam; Dopamine; Drug Interactions; Flumazenil; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Stress, Psychological; Time Factors | 1989 |
Behavioral analysis of zopiclone on the basis of their discriminative stimulus properties in the rat.
Topics: Animals; Anti-Anxiety Agents; Azabicyclo Compounds; Behavior, Animal; Benzodiazepines; Bicuculline; Discrimination Learning; Dose-Response Relationship, Drug; Flumazenil; Hypnotics and Sedatives; Male; Muscimol; Naphthyridines; Pentylenetetrazole; Piperazines; Piperidines; Rats; Rats, Inbred WKY; Ritanserin; Serotonin Antagonists; Sulfur Compounds | 1989 |
Pentylenetetrazol-induced seizure is not mediated by benzodiazepine receptors in vivo.
Topics: Animals; Electroencephalography; Flumazenil; Male; Papio; Pentylenetetrazole; Receptors, GABA-A; Seizures | 1987 |
Status epilepticus induced by pentylenetetrazole modulates in vivo [11C]Ro 15-1788 binding to benzodiazepine receptors. Effects of ligands acting at the supramolecular receptor complex.
Topics: Animals; Binding, Competitive; Brain; Flumazenil; Male; Papio; Pentylenetetrazole; Receptors, GABA-A; Status Epilepticus | 1988 |
The effect of agonists at the GABA-benzodiazepine-receptor-complex on the proconflict effect induced by beta-CCM and pentetrazol in rats.
Topics: Aminooxyacetic Acid; Animals; Azabicyclo Compounds; Carbolines; Conflict, Psychological; Convulsants; Diazepam; Flumazenil; Hypnotics and Sedatives; Male; Pentylenetetrazole; Phenobarbital; Piperazines; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1988 |
Discriminative stimulus properties of CGS 9896: interactions within the GABA/benzodiazepine receptor complex.
Topics: Animals; Carbolines; Chlordiazepoxide; Discrimination, Psychological; Dose-Response Relationship, Drug; Flumazenil; gamma-Aminobutyric Acid; Male; Pentobarbital; Pentylenetetrazole; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1988 |
Self-regulation of ICSS duration: effects of anxiogenic substances, benzodiazepine antagonists and antidepressants.
Topics: Adrenergic alpha-Antagonists; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Benzodiazepinones; Caffeine; Carbolines; Conditioning, Operant; Convulsants; Flumazenil; Humans; Male; Pentylenetetrazole; Pyrazoles; Rats; Rats, Inbred F344; Self Stimulation; Time Factors | 1985 |
Interoceptive stimuli produced by an anxiogenic drug are mimicked by benzodiazepine antagonists in rats pretreated with isoniazid.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepinones; Brain Chemistry; Convulsants; Discrimination, Psychological; Flumazenil; gamma-Aminobutyric Acid; Humans; Isoniazid; Male; Pentobarbital; Pentylenetetrazole; Pyrazoles; Rats | 1985 |
Does the benzodiazepine antagonist Ro 15-1788 reverse the actions of picrotoxin and pentylenetetrazole on social and exploratory behaviour?
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Exploratory Behavior; Flumazenil; Male; Motor Activity; Pentylenetetrazole; Picrotoxin; Rats; Social Behavior | 1985 |
Ro 15-1788, CGS 8216, picrotoxin, and pentylenetetrazol: do they antagonize anxiolytic drug effects through an anxiogenic action?
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Drug Interactions; Flumazenil; Humans; Injections, Intraperitoneal; Male; Pentylenetetrazole; Picrotoxin; Pyrazoles; Rats; Receptors, GABA-A | 1987 |
Tetrazepam: a benzodiazepine which dissociates sedation from other benzodiazepine activities. I. Psychopharmacological profile in rodents.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Diazepam; Feeding Behavior; Flumazenil; Male; Mice; Motor Activity; Pentylenetetrazole; Rats; Seizures | 1988 |
Convulsant component of a depressant benzodiazepine.
Topics: Animals; Benzodiazepinones; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1985 |
Proconflict effect of GABA receptor complex antagonists. Reversal by diazepam.
Topics: Animals; Benzodiazepinones; Bicuculline; Conflict, Psychological; Diazepam; Flumazenil; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1986 |
Apparent pA2 estimation of benzodiazepine receptor antagonists.
Topics: Animals; Diazepam; Drug Interactions; Female; Flumazenil; Male; Pentylenetetrazole; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1986 |
Chronic treatment with lorazepam and FG 7142 may change the effects of benzodiazepine receptor agonists, antagonists and inverse agonists by different mechanisms.
Topics: Animals; Carbolines; Drug Interactions; Drug Tolerance; Female; Flumazenil; Lorazepam; Mice; Pentylenetetrazole; Receptors, GABA-A | 1987 |
CGS 8216: agonist and diazepam-antagonist effects in rodents.
Topics: Animals; Ataxia; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Flumazenil; Male; Mice; Pentylenetetrazole; Pyrazoles; Rats; Rats, Inbred F344; Reinforcement, Psychology | 1986 |
The chlordiazepoxide/pentylenetetrazol discrimination: characterization of drug interactions and homeostatic responses to drug challenges.
Topics: Animals; Chlordiazepoxide; Discrimination, Psychological; Drug Interactions; Flumazenil; Generalization, Stimulus; Homeostasis; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Time Factors | 1988 |
Withdrawal from diazepam substitutes for the discriminative stimulus properties of pentylenetetrazol.
Topics: Animals; Diazepam; Discrimination Learning; Disease Models, Animal; Flumazenil; Male; Pentylenetetrazole; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 1988 |
An EEG investigation on the role of cerebello-rubral system in the effects of diazepam and pentobarbital.
Topics: Animals; Benzodiazepinones; Cerebellum; Diazepam; Electroencephalography; Female; Flumazenil; Male; Pentobarbital; Pentylenetetrazole; Picrotoxin; Rabbits; Red Nucleus | 1985 |
Anticonvulsant actions of fominoben: possible involvement of benzodiazepine receptors.
Topics: 3-Mercaptopropionic Acid; Aminophylline; Animals; Anticonvulsants; Benzodiazepinones; Binding, Competitive; Brain Chemistry; Carbolines; Flumazenil; Male; Mice; Morpholines; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures; Synaptosomes | 1984 |
RO 15-1788 selectively reverses antagonism of pentylenetetrazol-induced discriminative stimuli by benzodiazepines but not by barbiturates.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Barbiturates; Benzodiazepines; Benzodiazepinones; Diazepam; Flumazenil; Male; Pentobarbital; Pentylenetetrazole; Rats; Stimulation, Chemical | 1982 |
Distinct behavioral and pharmacological effects of two benzodiazepine antagonists: Ro 15-1788 and methyl beta-carboline.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepinones; Carbolines; Cats; Drug Synergism; Electroencephalography; Electrophysiology; Flumazenil; Indoles; Mice; Papio; Pentylenetetrazole; Seizures; Species Specificity | 1983 |
Benzodiazepine antagonist Ro 15-1788: neurological and behavioral effects.
Topics: Animals; Avoidance Learning; Behavior, Animal; Benzodiazepinones; Conditioning, Operant; Dogs; Dose-Response Relationship, Drug; Exploratory Behavior; Female; Flumazenil; Male; Motor Activity; Motor Skills; Muridae; Nervous System; Pentylenetetrazole; Rabbits; Rats; Receptors, Drug; Receptors, GABA-A; Reflex; Respiration; Saimiri; Seizures | 1982 |
Bidirectional effects of benzodiazepine receptor ligands against picrotoxin- and pentylenetetrazol-induced seizures.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Brain; Convulsants; Dose-Response Relationship, Drug; Flumazenil; Lorazepam; Male; Muridae; Pentylenetetrazole; Picrotoxin; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1983 |
On the convulsant action of Ro 5-4864 and the existence of a micromolar benzodiazepine binding site in rat brain.
Topics: Animals; Benzodiazepinones; Binding Sites; Brain; Convulsants; Diazepam; Electroshock; Flumazenil; Male; Mice; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1984 |
Proconvulsant action of CGS 8216.
Topics: Animals; Benzodiazepinones; Convulsants; Drug Synergism; Flumazenil; Male; Mice; Pentylenetetrazole; Picrotoxin; Pyrazoles; Seizures | 1983 |
Convulsions induced by submaximal dose of pentylenetetrazol in mice are antagonized by the benzodiazepine antagonist Ro 15-1788.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Flumazenil; Male; Mice; Pentylenetetrazole; Seizures | 1983 |
Anxiogenic aspects of diazepam withdrawal can be detected in animals.
Topics: Animals; Anxiety; Benzodiazepinones; Diazepam; Discrimination Learning; Flumazenil; Humans; Male; Pentobarbital; Pentylenetetrazole; Rats; Substance Withdrawal Syndrome | 1983 |
The partial benzodiazepine agonist properties of Ro 15-1788 in pentylenetetrazol-induced seizures in cats.
Topics: Animals; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Cats; Drug Interactions; Electroencephalography; Flumazenil; Pentylenetetrazole; Seizures | 1983 |
Anticonvulsant and antipunishment effects of toluene.
Topics: Animals; Benzodiazepinones; Conditioning, Operant; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Flumazenil; Male; Mice; Pentylenetetrazole; Punishment; Rats; Seizures; Time Factors; Toluene; Xylenes | 1984 |
Behavioural effects of pentylenetetrazole reversed by chlordiazepoxide and enhanced by RO 15-1788.
Topics: Animals; Behavior, Animal; Benzodiazepinones; Chlordiazepoxide; Flumazenil; Male; Motor Activity; Pentylenetetrazole; Rats; Time Factors | 1984 |
Bioassay of subjective effects associated with benzodiazepine withdrawal in animals: a novel direction in dependence research.
Topics: Animals; Benzodiazepinones; Biological Assay; Clonidine; Conditioning, Operant; Diazepam; Discrimination Learning; Flumazenil; Generalization, Stimulus; Humans; Male; Pentobarbital; Pentylenetetrazole; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 1984 |
Characterization of convulsions induced by methyl beta-carboline-3-carboxylate in mice.
Topics: Animals; Benzodiazepinones; Carbolines; Convulsants; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Electroencephalography; Flumazenil; Hypnotics and Sedatives; Indoles; Male; Mice; Pentylenetetrazole; Postural Balance; Time Factors | 1984 |
Behavioural evidence for partial agonist properties of RO 15-1788, a benzodiazepine receptor antagonist.
Topics: Animals; Behavior, Animal; Benzodiazepinones; Clorazepate Dipotassium; Conflict, Psychological; Cues; Discrimination, Psychological; Flumazenil; Male; Pentylenetetrazole; Rats | 1982 |
Defeat engenders pentylenetetrazole-appropriate responding in rats: antagonism by midazolam.
Topics: Agonistic Behavior; Animals; Anxiety; Conditioning, Operant; Discrimination, Psychological; Flumazenil; Generalization, Stimulus; Male; Midazolam; Pentylenetetrazole; Rats; Reinforcement Schedule; Social Behavior | 1994 |
Common modes of action of gamma-butyrolactones and pentylenetetrazol on the GABAA receptor-ionophore complex.
Topics: 4-Butyrolactone; Androstanes; Animals; Azasteroids; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Cerebral Cortex; Convulsants; Electrophysiology; Flumazenil; GABA Antagonists; Ionophores; Male; Neurons; Patch-Clamp Techniques; Pentylenetetrazole; Prosencephalon; Rats; Rats, Wistar; Receptors, GABA-A; Stereoisomerism; Synaptosomes | 1994 |
Evidence for central benzodiazepine receptor heterogeneity from behavior tests.
Topics: Animals; Anxiety; Behavior, Animal; Benzodiazepines; Body Temperature; Central Nervous System; Dose-Response Relationship, Drug; Feeding Behavior; Flumazenil; Male; Motor Activity; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures | 1994 |
Discriminative stimulus properties of a new anxiolytic, DN-2327, in rats.
Topics: Animals; Anti-Anxiety Agents; Buspirone; Cues; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Flumazenil; Generalization, Stimulus; Isoindoles; Male; Naphthyridines; Pentobarbital; Pentylenetetrazole; Rats; Rats, Wistar; Spiro Compounds | 1993 |
Chronic benzodiazepine administration. XII. Anticonvulsant cross-tolerance but distinct neurochemical effects of alprazolam and lorazepam.
Topics: Alprazolam; Animals; Anticonvulsants; Brain Chemistry; Cerebral Cortex; Down-Regulation; Drug Tolerance; Flumazenil; Hippocampus; Lorazepam; Male; Mice; Pentylenetetrazole; Receptors, GABA-A; Seizures | 1993 |
Pharmacological characterization of benzodiazepine receptor ligands with intrinsic efficacies ranging from high to zero.
Topics: Acoustic Stimulation; Amnesia; Animals; Anticonvulsants; Conditioning, Operant; Eating; Female; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Haplorhini; Ligands; Male; Mice; Pentylenetetrazole; Postural Balance; Rats; Reinforcement, Psychology; Sleep | 1993 |
Effects of the non-NMDA antagonists NBQX and the 2,3-benzodiazepine GYKI 52466 on different seizure types in mice: comparison with diazepam and interactions with flumazenil.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Excitatory Amino Acid Antagonists; Flumazenil; Male; Mice; Muscle Relaxants, Central; Pentylenetetrazole; Quinoxalines; Receptors, AMPA; Reflex; Seizures; Synaptic Transmission | 1994 |
Repeated treatment with alpidem, a new anxiolytic, does not induce tolerance or physical dependence.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Bicuculline; Carbolines; Convulsants; Diazepam; Drug Tolerance; Flumazenil; Imidazoles; Isoniazid; Male; Mice; Pentylenetetrazole; Pyridines; Seizures; Substance Withdrawal Syndrome; Substance-Related Disorders | 1993 |
A system for testing the development and reversal of anticonvulsant tolerance to benzodiazepines in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Carbolines; Diazepam; Drug Tolerance; Flumazenil; Flunitrazepam; Infusion Pumps, Implantable; Infusions, Parenteral; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Seizures; Solvents; Time Factors | 1993 |
Dehydroepiandrosterone is an anxiolytic in mice on the plus maze.
Topics: Animals; Anti-Anxiety Agents; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Diazepam; Ethanol; Flumazenil; Male; Mice; Mice, Inbred C57BL; Motor Activity; Pentylenetetrazole; Receptors, GABA | 1994 |
Conflicting evidence regarding the efficacy of ondansetron in benzodiazepine withdrawal.
Topics: Animals; Anti-Anxiety Agents; Chlordiazepoxide; Conditioning, Psychological; Discrimination Learning; Flumazenil; Male; Ondansetron; Pentylenetetrazole; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1993 |
Imidazenil, a new partial agonist of benzodiazepine receptors, reverses the inhibitory action of isoniazid and stress on gamma-aminobutyric acidA receptor function.
Topics: Animals; Benzodiazepines; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Flumazenil; GABA-A Receptor Antagonists; Imidazoles; Isoniazid; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Stress, Physiological; Sulfur Radioisotopes; Tritium | 1994 |
Molecular requirement for anticonvulsant activity in a series of thiazolo-1,4-benzodiazepine derivatives and comparison with classical benzodiazepines.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Benzodiazepines; Binding, Competitive; Body Temperature; Flumazenil; Flunitrazepam; In Vitro Techniques; Injections, Intraperitoneal; Male; Mice; Mice, Inbred DBA; Molecular Weight; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Structure-Activity Relationship; Thiazoles | 1993 |
Anticonvulsant activity of flumazenil in rats during ontogenetic development.
Topics: Aging; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clonic; Female; Flumazenil; Male; Pentylenetetrazole; Rats; Rats, Wistar; Seizures | 1993 |
Anticonvulsant profile of the imidazoquinazolines NNC 14-0185 and NNC 14-0189 in rats and mice.
Topics: Acoustic Stimulation; Amygdala; Animals; Anticonvulsants; Bicuculline; Carbolines; Clonazepam; Diazepam; Electroshock; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; Kindling, Neurologic; Male; Mice; Mice, Inbred DBA; Mice, Inbred Strains; Pentylenetetrazole; Quinazolines; Rats; Rats, Wistar; Seizures | 1996 |
In vivo modulation of benzodiazepine receptor function after inhibition of endogenous gamma-aminobutyyric acid synthesis.
Topics: Allylglycine; Animals; Binding, Competitive; Brain; Convulsants; Diazepam; Electroencephalography; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Ligands; Male; Papio; Pentylenetetrazole; Tomography, Emission-Computed | 1997 |
Stimulatory effect of diazepam on gastric acid secretion in the continuously perfused stomach in rats under urethane anesthesia.
Topics: 3-Mercaptopropionic Acid; Analysis of Variance; Anesthetics, Intravenous; Animals; Atropine; Diazepam; Flumazenil; GABA Agents; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; Gastric Acid; Gastric Mucosa; Hexamethonium; Isoquinolines; Male; Parasympatholytics; Pentylenetetrazole; Picrotoxin; Pylorus; Rats; Rats, Wistar; Receptors, GABA; Urethane; Vagotomy | 1997 |
Anticonvulsant activity of azirino[1,2-d][1,4]benzodiazepines and related 1,4-benzodiazepines in mice.
Topics: Animals; Anticonvulsants; Benzodiazepines; Carbolines; Cell Line; Convulsants; Flumazenil; GABA Modulators; Male; Membranes; Mice; Mice, Inbred DBA; Movement; Pentylenetetrazole; Radioligand Assay; Receptors, GABA-A; Seizures | 1997 |
Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Carbolines; Convulsants; Diazepam; Disease Models, Animal; Electroconvulsive Therapy; Epilepsy; Excitatory Amino Acid Agonists; Flumazenil; GABA-A Receptor Antagonists; Kindling, Neurologic; Levetiracetam; Male; Mice; Pentylenetetrazole; Piracetam; Rats; Rats, Sprague-Dawley; Seizures | 1998 |
Acute pentylenetetrazol injection reduces rat GABAA receptor mRNA levels and GABA stimulation of benzodiazepine binding with No effect on benzodiazepine binding site density.
Topics: Animals; Autoradiography; Brain; Down-Regulation; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Male; Muscimol; Pentylenetetrazole; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Time Factors; Transcription, Genetic; Tritium | 1999 |
Antagonist-induced reversal of functional and structural measures of hippocampal benzodiazepine tolerance.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Autoradiography; Behavior, Animal; Benzodiazepines; Convulsants; Drug Tolerance; Electrophysiology; Flumazenil; Flurazepam; GABA Modulators; GABA-A Receptor Antagonists; Hippocampus; Hypnotics and Sedatives; Immunohistochemistry; Male; Patch-Clamp Techniques; Pentylenetetrazole; Pyridines; Rats; Rats, Sprague-Dawley; Seizures; Zolpidem | 1999 |
Discriminative stimulus properties of alprazolam.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; Benzodiazepines; Conditioning, Operant; Convulsants; Discrimination, Psychological; Dose-Response Relationship, Drug; Flumazenil; Fluvoxamine; GABA Agents; Hypnotics and Sedatives; Male; Pentylenetetrazole; Rats; Rats, Wistar | 2000 |
Reduction of pentylenetetrazol-induced convulsions by the octadecaneuropeptide ODN.
Topics: Acoustic Stimulation; Amino Acid Sequence; Animals; Carbolines; Convulsants; Diazepam Binding Inhibitor; Electric Stimulation; Flumazenil; Injections, Intraventricular; Male; Mice; Mice, Inbred DBA; Molecular Sequence Data; Neuropeptides; Pentylenetetrazole; Peptide Fragments; Receptors, GABA-A; Seizures | 1999 |
Kindling induced by pentylenetetrazole in rats is not directly associated with changes in the expression of NMDA or benzodiazepine receptors.
Topics: Aminoquinolines; Animals; Cerebral Cortex; Convulsants; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Flumazenil; Hippocampus; Imidazoles; Kindling, Neurologic; Male; Pentylenetetrazole; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Species Specificity; Time Factors | 2000 |
Topiramate modulates GABA-evoked currents in murine cortical neurons by a nonbenzodiazepine mechanism.
Topics: Action Potentials; Animals; Anticonvulsants; Cells, Cultured; Cerebral Cortex; Clonazepam; Evoked Potentials; Flumazenil; Fructose; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Mice; Neurons; Patch-Clamp Techniques; Pentylenetetrazole; Receptors, GABA; Seizures; Topiramate | 2000 |
Hypnotic, anticonvulsant and muscle relaxant effects of Rubus brasiliensis. Involvement of GABA(A)-system.
Topics: Animals; Anticonvulsants; Barbiturates; Brazil; Diazepam; Flumazenil; GABA Modulators; Hexanes; Hypnotics and Sedatives; Male; Mice; Muscle Relaxants, Central; Pentylenetetrazole; Plant Extracts; Plants, Medicinal; Receptors, GABA-A; Seizures | 2000 |
Use of negatively reinforcing electrical brain stimulation to detect conventional and nonconventional anxiolytics as well as an anxiogenic drug.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Brain; Buspirone; Carbolines; Convulsants; Diazepam; Electric Stimulation; Electrodes; Flumazenil; GABA Modulators; Male; Pentylenetetrazole; Rats; Rats, Long-Evans; Reinforcement, Psychology | 2001 |
Effects of striatal injections of GABA(A) receptor agonists and antagonists in a genetic animal model of paroxysmal dystonia.
Topics: Animals; Bicuculline; Binding Sites; Corpus Striatum; Cricetinae; Dystonia; Female; Flumazenil; Flurazepam; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Male; Mesocricetus; Microinjections; Muscimol; Pentylenetetrazole; Phenobarbital | 2002 |
GABA(A)-benzodiazepine receptor complex sensitivity in 5-HT(1A) receptor knockout mice on a 129/Sv background.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Diazepam; Ethanol; Fever; Flumazenil; GABA Antagonists; Hypnotics and Sedatives; Male; Maze Learning; Mice; Mice, Knockout; Pentylenetetrazole; Phenobarbital; Receptors, GABA-A; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Reflex; Species Specificity; Stress, Physiological | 2002 |
Effects of GABA(A) compounds on mCPP drug discrimination in rats.
Topics: Alprazolam; Animals; Azides; Benzodiazepines; Bicuculline; Conditioning, Operant; Discrimination, Psychological; Flumazenil; GABA Agonists; GABA Antagonists; Male; Pentylenetetrazole; Piperazines; Rats; Rats, Long-Evans; Receptors, GABA-A | 2002 |
5-ethoxymethyl-7-fluoro-3-oxo-1,2,3,5-tetrahydrobenzo[4,5]imidazo[1,2a]pyridine-4-N-(2-fluorophenyl)carboxamide (RWJ-51204), a new nonbenzodiazepine anxiolytic.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Central Nervous System Depressants; Chlordiazepoxide; Conflict, Psychological; Conscious Sedation; Convulsants; Drug Interactions; Ethanol; Flumazenil; GABA Modulators; Imidazoles; Lorazepam; Male; Mice; Motor Activity; Pentylenetetrazole; Postural Balance; Pyridones; Rats; Rats, Long-Evans; Receptors, GABA-A; Saimiri; Seizures | 2002 |
Anticonvulsant and antiepileptogenic effects of GABAA receptor ligands in pentylenetetrazole-kindled mice.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Dehydroepiandrosterone Sulfate; Diazepam; Dose-Response Relationship, Drug; Epilepsy; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; Isoxazoles; Kindling, Neurologic; Ligands; Mice; Pentylenetetrazole; Pregnanediones; Receptors, GABA-A | 2004 |
Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice.
Topics: Animals; Anticonvulsants; Benzoquinones; Diazepam; Electroshock; Flumazenil; GABA Modulators; Injections, Intraperitoneal; Male; Mice; Mice, Inbred BALB C; Motor Activity; Nigella sativa; Pentylenetetrazole; Phytotherapy; Plant Extracts; Seeds; Seizures | 2004 |
Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures.
Topics: Animals; Anticonvulsants; Bromides; Chronic Disease; Disease Models, Animal; Dog Diseases; Dogs; Drug Therapy, Combination; Epilepsy; Flumazenil; GABA Agonists; GABA-A Receptor Agonists; Imidazoles; Pentylenetetrazole; Phenobarbital; Potassium Compounds; Primidone; Receptors, GABA-A; Seizures; Substance Withdrawal Syndrome; Treatment Outcome | 2004 |
Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats.
Topics: Animals; Anticonvulsants; Benzoquinones; Convulsants; Diazepam; Epilepsy; Flumazenil; Injections, Intraventricular; Male; Nigella; Pentylenetetrazole; Phytotherapy; Rats; Rats, Wistar; Seeds; Seizures | 2005 |
Design and synthesis of new 2-substituted-5-(2-benzylthiophenyl)-1,3,4-oxadiazoles as benzodiazepine receptor agonists.
Topics: Animals; Anticonvulsants; Benzodiazepines; Convulsants; Diazepam; Drug Design; Electroshock; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; Mice; Models, Molecular; Molecular Structure; Oxadiazoles; Pentylenetetrazole; Seizures; Structure-Activity Relationship | 2005 |
TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates.
Topics: Acoustic Stimulation; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Anti-Anxiety Agents; Anticonvulsants; Autoradiography; Conditioning, Operant; Convulsants; Drinking; Emotions; Fear; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; Humans; Male; Mice; Pentylenetetrazole; Postural Balance; Protein Binding; Pyridazines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Recombinant Proteins; Reflex, Startle; Saimiri; Substance Withdrawal Syndrome; Triazoles | 2006 |
Influence of adenosine receptor agonists on benzodiazepine withdrawal signs in mice.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Male; Mice; Pentylenetetrazole; Phenethylamines; Purinergic Agonists; Purinergic P1 Receptor Agonists; Purinergic P2 Receptor Agonists; Seizures; Substance Withdrawal Syndrome; Temazepam | 2005 |
The proconvulsant effects of the GABAA alpha5 subtype-selective compound RY-080 may not be alpha5-mediated.
Topics: Alkynes; Animals; Benzodiazepines; Cells, Cultured; Convulsants; Female; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; Imidazoles; Ligands; Male; Mice; Oocytes; Pentylenetetrazole; Receptors, GABA-A; Seizures; Xenopus laevis | 2006 |
Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors.
Topics: Animals; Anticonvulsants; Antidotes; Convulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy, Absence; Flumazenil; Injections, Intraperitoneal; Male; Mice; Mice, Inbred BALB C; Naloxone; Narcotic Antagonists; Passiflora; Pentylenetetrazole; Phytotherapy; Plant Components, Aerial; Plant Extracts; Receptors, GABA-A; Receptors, Opioid; Sodium Chloride; Treatment Outcome | 2007 |
Anticonvulsive effects of intracerebroventricular administration of rutin in rats.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clonic; Flumazenil; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Injections, Intraventricular; Male; Pentylenetetrazole; Rats; Rats, Wistar; Rutin; Seizures | 2008 |
Anticonvulsant effect of a natural compound alpha,beta-epoxy-carvone and its action on the nerve excitability.
Topics: Action Potentials; Animals; Anticonvulsants; Convulsants; Cyclohexane Monoterpenes; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Epilepsy; Flumazenil; GABA Modulators; In Vitro Techniques; Male; Mice; Monoterpenes; Pentylenetetrazole; Physical Stimulation; Picrotoxin; Rats; Rats, Wistar; Sciatic Nerve | 2008 |
Central action of Araucaria angustifolia seed lectin in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Flumazenil; Lectins; Locomotion; Male; Mice; Pentylenetetrazole; Phytotherapy; Plant Extracts; Reaction Time; Seeds; Seizures; Strychnine | 2009 |
Effects of isopulegol on pentylenetetrazol-induced convulsions in mice: possible involvement of GABAergic system and antioxidant activity.
Topics: Animals; Anticonvulsants; Antioxidants; Catalase; Cyclohexane Monoterpenes; Dose-Response Relationship, Drug; Drug Interactions; Flumazenil; gamma-Aminobutyric Acid; Glutathione; Hippocampus; Lipid Peroxidation; Male; Mice; Pentylenetetrazole; Phytotherapy; Plant Extracts; Receptors, GABA-A; Seizures; Terpenes | 2009 |
Involvement of GABAergic non-benzodiazepine sites in the anxiolytic-like and sedative effects of the flavonoid baicalein in mice.
Topics: Animals; Anti-Anxiety Agents; Dehydroepiandrosterone Sulfate; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Ether; Female; Fenclonine; Flavanones; Flumazenil; GABA Agonists; GABA Antagonists; Injections, Intraventricular; Maze Learning; Mice; Pentylenetetrazole; Seizures; Sleep | 2011 |
Chronic benzodiazepine treatment does not alter interactions between positive GABA(A) modulators and flumazenil or pentylenetetrazole in monkeys.
Topics: Animals; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Interactions; Female; Flumazenil; GABA Modulators; Macaca mulatta; Male; Midazolam; Pentylenetetrazole; Receptors, GABA-A | 2011 |
3-Hydroxy-2'-methoxy-6-methylflavone: a potent anxiolytic with a unique selectivity profile at GABA(A) receptor subtypes.
Topics: Animals; Anti-Anxiety Agents; Diazepam; Dose-Response Relationship, Drug; Fatty Acids, Volatile; Flavones; Flumazenil; gamma-Aminobutyric Acid; Humans; Male; Mice; Mice, Inbred BALB C; Molecular Structure; Motor Activity; Oocytes; Pentylenetetrazole; Receptors, GABA-A; Recombinant Proteins; Thiopental; Xenopus | 2011 |
Neuroprotective effects of vitexin, a flavonoid, on pentylenetetrazole-induced seizure in rats.
Topics: Animals; Anticonvulsants; Apigenin; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Male; Neuroprotective Agents; Pennisetum; Pentylenetetrazole; Rats; Rats, Wistar; Seizures | 2012 |
Anticonvulsant effects of Fuzi total alkaloid on pentylenetetrazole-induced seizure in mice.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Flumazenil; GABA-A Receptor Antagonists; Hippocampus; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Phytotherapy; Plant Extracts; Proto-Oncogene Proteins c-fos; Receptors, GABA-A; Seizures | 2013 |
Monoterpenoid terpinen-4-ol exhibits anticonvulsant activity in behavioural and electrophysiological studies.
Topics: Animals; Anticonvulsants; Behavior, Animal; Binding Sites; Electrophysiological Phenomena; Flumazenil; GABA-A Receptor Antagonists; GABAergic Neurons; Infusions, Intraventricular; Injections, Intraperitoneal; Male; Mice; Monoterpenes; Pentylenetetrazole; Rats; Rats, Wistar; Receptors, GABA-A; Seizures; Terpenes | 2014 |
Potential mechanisms involved in the anticonvulsant effect of walnut extract on pentylenetetrazole-induced seizure.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Ethosuximide; Flumazenil; Juglans; Male; Pentylenetetrazole; Plant Extracts; Rats; Rats, Wistar; Seizures | 2014 |
3,4,5-Trimethoxycinnamic acid, one of the constituents of Polygalae Radix exerts anti-seizure effects by modulating GABAAergic systems in mice.
Topics: Animals; Anticonvulsants; Cinnamates; Electroshock; Flumazenil; GABA Antagonists; Male; Mice; Pentylenetetrazole; Plant Roots; Polygala; Receptors, GABA-A; Seizures | 2016 |
Anticonvulsant Activity of Hydroalcoholic Extract of Citrullus colocynthis Fruit: Involvement of Benzodiazepine and Opioid Receptors.
Topics: Animals; Anticonvulsants; Benzodiazepines; Citrullus colocynthis; Flavonoids; Flumazenil; Fruit; Herb-Drug Interactions; Male; Medicine, Arabic; Mice; Naloxone; Pentylenetetrazole; Plant Extracts; Receptors, Opioid; Seizures | 2016 |
Intra-hippocampal microinjection of oxytocin produced antiepileptic effect on the pentylenetetrazol-induced epilepsy in rats.
Topics: Animals; Anticonvulsants; Diazepam; Epilepsy; Flumazenil; Hippocampus; Male; Microinjections; Oxytocics; Oxytocin; Pentylenetetrazole; Rats; Tocolytic Agents; Vasotocin | 2017 |
(+)-Dehydrofukinone modulates membrane potential and delays seizure onset by GABAa receptor-mediated mechanism in mice.
Topics: Animals; Anticonvulsants; Female; Flumazenil; GABA Modulators; Membrane Potentials; Mice; Pentylenetetrazole; Receptors, GABA-A; Seizures; Sesquiterpenes | 2017 |
Anticonvulsant effects of Senna spectabilis on seizures induced by chemicals and maximal electroshock.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Electric Stimulation; Flumazenil; Male; Mice; Pentylenetetrazole; Pilocarpine; Plant Extracts; Plant Leaves; Plants, Medicinal; Random Allocation; Seizures; Senna Plant | 2018 |
Neuropharmacological effects of d-pinitol and its possible mechanisms of action.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Flumazenil; Hypnotics and Sedatives; Inositol; Mice; Mice, Inbred BALB C; Neuropharmacology; Pentylenetetrazole; Seizures; Yohimbine | 2019 |
Effect of Curcuma zedoaria hydro-alcoholic extract on learning, memory deficits and oxidative damage of brain tissue following seizures induced by pentylenetetrazole in rat.
Topics: Animals; Anticonvulsants; Antioxidants; Brain Chemistry; Convulsants; Curcuma; Flumazenil; GABA Modulators; Learning Disabilities; Male; Malondialdehyde; Maze Learning; Memory Disorders; Nitric Oxide; Oxidative Stress; Pentylenetetrazole; Plant Extracts; Rats; Rats, Wistar; Seizures | 2020 |
Cymbopogon citratus (DC.) Stapf, citral and geraniol exhibit anticonvulsant and neuroprotective effects in pentylenetetrazole-induced seizures in zebrafish.
Topics: Acyclic Monoterpenes; Animals; Anticonvulsants; Brain Chemistry; Catalase; Cymbopogon; Disease Models, Animal; Flumazenil; Glutathione; Malondialdehyde; Medicine, Traditional; Neuroprotective Agents; Oils, Volatile; Oxidative Stress; Pentylenetetrazole; Plant Extracts; Plant Leaves; Receptors, GABA-A; Seizures; Zebrafish | 2021 |
Probable mechanisms involved in the antiepileptic activity of Clerodendrum polycephalum Baker (Labiatae) leaf extract in mice exposed to chemical-induced seizures.
Topics: Animals; Anticonvulsants; Antioxidants; Arginine; Clerodendrum; Cyclooxygenase 2; Flumazenil; Guanosine Monophosphate; Kainic Acid; Lamiaceae; Methylene Blue; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type I; Pentylenetetrazole; Picrotoxin; Plant Extracts; Receptors, GABA-A; Seizures; Soluble Guanylyl Cyclase; Spasm | 2022 |
Effects of Hyssopus Officinalis Hydroalcoholic Extract on Pentylenetetrazol-Induced Convulsive Seizures in Rat.
Topics: Animals; Anticonvulsants; Antioxidants; Flumazenil; Hyssopus Plant; Kindling, Neurologic; Nitric Oxide; Pentylenetetrazole; Plant Extracts; Plant Oils; Rats; Receptors, GABA; Seizures | 2022 |