flumazenil has been researched along with ketamine in 34 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (5.88) | 18.7374 |
| 1990's | 6 (17.65) | 18.2507 |
| 2000's | 13 (38.24) | 29.6817 |
| 2010's | 8 (23.53) | 24.3611 |
| 2020's | 5 (14.71) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Adkison, KK; Humphreys, JE; Mahar Doan, KM; Polli, JW; Serabjit-Singh, CJ; Shampine, LJ; Webster, LO; Wring, SA | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Radev, R | 1 |
| Cheng, CR; Chuang, JY; Lai, KB; Lee, Y; Mok, MS; Sit, KF; Steen, SN; Wei, TT; Wong, KL; Wu, KH | 1 |
| Garamvölgyi, G; Hamar, O | 1 |
| Johnston, IG; Restall, J; Robinson, DN | 1 |
| Fuccaro, P; Mantero, L; Mazzarello, MR; Roccatagliata, DC; Sburlati, E | 1 |
| Garamvölgyi, G; Hamar, O; Kálmán, A | 1 |
| Clark, JD; Hatch, RC; Kitzman, JV; Zahner, JM | 1 |
| Fujigaki, T; Makita, T; Nakamura, H; Shibata, O; Sumikawa, K; Tsujita, T | 1 |
| Durham, S; Fleet, T; Hollis, S; McGlone, R | 1 |
| Farver, TB; Ilkiw, JE; McNeal, D; Steffey, EP; Suter, C | 1 |
| Horne, WA; Kelly, BT; Larsen, RS; Loomis, MR; Sladky, KK; Stoskopf, MK | 1 |
| Masuzawa, M; Miyamoto, E; Murayama, T; Nagata, A; Nakao, S; Shingu, K | 1 |
| Aalto, S; Hietala, J; Kaisti, KK; Korpi, ER; Långsjö, JW; Metsähonkala, L; Någren, K; Salmi, E; Scheinin, H | 1 |
| Eskandari, MH; Vesal, N | 1 |
| Cappell, MS | 1 |
| Hikasa, Y; Ueoka, N | 2 |
| Baumgartner, C; Ebner, J; Erhardt, W; Henke, J; Wehr, U | 1 |
| Bogerts, B; Grosser, O; Heinzel, A; Northoff, G; Otto, H; Poeppel, TD; Steinke, R | 1 |
| Cardenas, R; Quintero, L; Suarez-Roca, H | 1 |
| Bailey, AM; Baum, RA; Horn, K; Justice, SN; Lewis, T; Morizio, K; Schultz, A; Weant, K | 1 |
| Álvaro-Bartolomé, M; García-Sevilla, JA; Salort, G | 1 |
| Ji, MH; Mao, MJ; Qiu, LL; Yang, JJ; Zhang, H; Zhang, L | 1 |
| Chen, Y; Fu, C; Hu, R; Huang, C; Jiang, H; Li, C; Sun, Y; Tang, D; Wang, H; Yan, J; Zhu, J | 1 |
| Hikasa, Y; Kamohara, H; Kamohara, T | 1 |
| Amari, M; Bonato, F; Brioschi, FA; Di Cesare, F; Giordano, A; Magnone, W; Moretti, P; Pecile, A; Rabbogliatti, V; Ravasio, G | 1 |
| Ernst, M; Handforth, A; Singh, RP; Treven, M | 1 |
3 review(s) available for flumazenil and ketamine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Sedation and analgesia for gastrointestinal endoscopy during pregnancy.
Topics: Analgesia; Analgesics, Opioid; Cholangiopancreatography, Endoscopic Retrograde; Conscious Sedation; Diazepam; Endoscopy, Gastrointestinal; Female; Fentanyl; Fetus; Flumazenil; Humans; Hypnotics and Sedatives; Ketamine; Lidocaine; Meperidine; Naloxone; Pregnancy; Propofol; Risk Assessment; Triage | 2006 |
Review of Intranasally Administered Medications for Use in the Emergency Department.
Topics: Administration, Intranasal; Anesthetics, Dissociative; Anticonvulsants; Antidotes; Antipsychotic Agents; Dexmedetomidine; Emergency Service, Hospital; Fentanyl; Flumazenil; Haloperidol; Humans; Hydromorphone; Hypnotics and Sedatives; Ketamine; Lorazepam; Midazolam; Naloxone; Narcotic Antagonists; Narcotics | 2017 |
7 trial(s) available for flumazenil and ketamine
| Article | Year |
|---|---|
[Does flumazenil antagonize the anesthetic effect of ketamine, etomidate or thiopental?].
Topics: Adult; Etomidate; Female; Flumazenil; Humans; Ketamine; Male; Thiopental | 1990 |
Flumazenil in ketamine and midazolam anaesthesia.
Topics: Adolescent; Adult; Anesthesia Recovery Period; Anesthesia, Intravenous; Double-Blind Method; Female; Flumazenil; Humans; Ketamine; Midazolam; Middle Aged; Patient Acceptance of Health Care; Postoperative Complications | 1990 |
Fentanyl-midazolam-flumazenil anesthesia for induced abortion.
Topics: Abortion, Induced; Adolescent; Adult; Ambulatory Care Facilities; Anesthesia Recovery Period; Diazepam; Drug Therapy, Combination; Female; Fentanyl; Flumazenil; Humans; Ketamine; Meperidine; Midazolam; Pain Measurement; Pregnancy; Random Allocation | 1989 |
A comparison of intramuscular ketamine with high dose intramuscular midazolam with and without intranasal flumazenil in children before suturing.
Topics: Administration, Intranasal; Child; Child, Preschool; Conscious Sedation; Dose-Response Relationship, Drug; Drug Therapy, Combination; Emergency Service, Hospital; Female; Flumazenil; Humans; Infant; Injections, Intramuscular; Ketamine; Male; Midazolam; Sutures; Wounds and Injuries | 2001 |
The effect of intravenous administration of variable-dose flumazenil after fixed-dose ketamine and midazolam in healthy cats.
Topics: Anesthetics, Intravenous; Animals; Antidotes; Behavior, Animal; Cats; Dose-Response Relationship, Drug; Drug Interactions; Female; Flumazenil; Injections, Intravenous; Ketamine; Male; Midazolam; Reference Values | 2002 |
Sedative effects of midazolam and xylazine with or without ketamine and detomidine alone following intranasal administration in Ring-necked Parakeets.
Topics: Administration, Intranasal; Adrenergic alpha-Antagonists; Animals; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Combinations; Female; Flumazenil; Heart Rate; Hypnotics and Sedatives; Imidazoles; Ketamine; Male; Midazolam; Parakeets; Prospective Studies; Respiration; Time Factors; Treatment Outcome; Xylazine; Yohimbine | 2006 |
S-ketamine and GABA-A-receptor interaction in humans: an exploratory study with I-123-iomazenil SPECT.
Topics: Adult; Analysis of Variance; Anesthetics, Dissociative; Brain Mapping; Brief Psychiatric Rating Scale; Case-Control Studies; Cerebral Cortex; Female; Flumazenil; Humans; Hydrocortisone; Iodine Radioisotopes; Ketamine; Male; Prolactin; Receptors, GABA-A; Tomography, Emission-Computed, Single-Photon; Young Adult | 2008 |
24 other study(ies) available for flumazenil and ketamine
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Cell Line; Cell Membrane Permeability; Central Nervous System Agents; Dogs; Drug Delivery Systems; Permeability; Pharmaceutical Preparations | 2002 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
[A comparison between thiopental, midazolam-ketalar and midazolam-ketalar-aneksat for anesthesia during cesarean section].
Topics: Anesthesia, Obstetrical; Cesarean Section; Drug Evaluation; Drug Therapy, Combination; Female; Flumazenil; Humans; Ketamine; Preanesthetic Medication; Pregnancy; Thiopental | 1991 |
Fentanyl-midazolam-flumazenil anaesthesia during induced abortion.
Topics: Abortion, Induced; Adult; Anesthesia, Obstetrical; Female; Fentanyl; Flumazenil; Humans; Ketamine; Midazolam | 1990 |
[Flumazenil: possible suppression of the antipsychotic effect of diazepam in anesthesia with ketamine].
Topics: Adult; Diazepam; Female; Flumazenil; Humans; Ketamine; Male; Middle Aged; Random Allocation | 1990 |
Comparison of five preanesthetic medicaments in thiopental-anesthetized cats: antagonism by selected compounds.
Topics: 4-Aminopyridine; Acepromazine; Aminopyridines; Anesthesia, General; Animals; Arousal; Benzodiazepinones; Cats; Central Nervous System Stimulants; Convulsants; Diazepam; Drug Antagonism; Female; Flumazenil; Ketamine; Male; Meperidine; Naloxone; Pentobarbital; Preanesthetic Medication; Sodium Chloride; Xylazine; Yohimbine | 1984 |
Effects of intravenous anesthetics on phosphatidylinositol turnover in rat cerebral cortical prisms.
Topics: Anesthetics, Intravenous; Animals; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Droperidol; Fentanyl; Flumazenil; Inositol Phosphates; Ketamine; Male; Naloxone; Norepinephrine; Phosphatidylinositols; Prazosin; Rats; Rats, Wistar; Thiamylal | 1994 |
Cardiorespiratory effects of medetomidine-butorphanol, medetomidine-butorphanol-diazepam, and medetomidine-butorphanol-ketamine in captive red wolves (Canis rufus).
Topics: Adrenergic alpha-Antagonists; Anesthetics, Dissociative; Animals; Animals, Zoo; Blood Pressure; Body Temperature; Butorphanol; Diazepam; Drug Combinations; Female; Flumazenil; GABA Modulators; Heart Rate; Hypertension; Hypnotics and Sedatives; Imidazoles; Immobilization; Ketamine; Male; Medetomidine; Muscle Relaxation; Naloxone; Narcotic Antagonists; Narcotics; Respiration; Wolves | 2002 |
Inhibitory effect of propofol on ketamine-induced c-Fos expression in the rat posterior cingulate and retrosplenial cortices is mediated by GABAA receptor activation.
Topics: Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Bicuculline; Cerebral Cortex; Electroencephalography; Excitatory Amino Acid Antagonists; Flumazenil; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; Gene Expression Regulation; Genes, fos; Gyrus Cinguli; Hemodynamics; Image Processing, Computer-Assisted; Immunohistochemistry; Ketamine; Male; Propofol; Rats; Rats, Wistar | 2003 |
Subanesthetic ketamine does not affect 11C-flumazenil binding in humans.
Topics: Adult; Brain; Excitatory Amino Acid Antagonists; Flumazenil; GABA Modulators; Humans; Infusions, Intravenous; Ketamine; Male; Positron-Emission Tomography; Receptors, GABA-A | 2005 |
Antagonistic effects of atipamezole, flumazenil and 4-aminopyridine against anaesthesia with medetomidine, midazolam and ketamine combination in cats.
Topics: 4-Aminopyridine; Anesthesia; Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Arousal; Body Temperature; Cats; Dose-Response Relationship, Drug; Flumazenil; Heart Rate; Imidazoles; Injections, Intravenous; Injections, Subcutaneous; Ketamine; Male; Medetomidine; Midazolam | 2008 |
Partial antagonization of midazolam-medetomidine-ketamine in cats--atipamezole versus combined atipamezole and flumazenil.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Blood Pressure; Cats; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Modulators; Heart Rate; Imidazoles; Injections, Intravenous; Injections, Subcutaneous; Ketamine; Male; Medetomidine; Midazolam; Respiration; Time Factors | 2007 |
Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord.
Topics: Analgesics; Animals; Diazepam; Disease Models, Animal; Excitatory Postsynaptic Potentials; Flumazenil; Formaldehyde; GABA Modulators; gamma-Aminobutyric Acid; Glutamic Acid; Hyperalgesia; Ketamine; Male; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Stress, Psychological; Swimming; Time Factors | 2011 |
Effects in cats of atipamezole, flumazenil and 4-aminopyridine on stress-related neurohormonal and metabolic responses induced by medetomidine, midazolam and ketamine.
Topics: 4-Aminopyridine; Anesthesia; Anesthetics, Combined; Animals; Arousal; Cats; Dose-Response Relationship, Drug; Flumazenil; Imidazoles; Ketamine; Medetomidine; Midazolam; Respiration | 2015 |
Ketamine-induced hypnosis and neuroplasticity in mice is associated with disrupted p-MEK/p-ERK sequential activation and sustained upregulation of survival p-FADD in brain cortex: Involvement of GABA
Topics: Analgesics; Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fas-Associated Death Domain Protein; Flumazenil; GABA Modulators; Immobility Response, Tonic; Ketamine; Male; MAP Kinase Signaling System; Mice; Nerve Tissue Proteins; Neuronal Plasticity; Receptors, GABA-A; Reflex, Righting; Time Factors | 2019 |
Overinhibition mediated by parvalbumin interneurons might contribute to depression-like behavior and working memory impairment induced by lipopolysaccharide challenge.
Topics: Animals; Behavior, Animal; Depression; Disease Models, Animal; Excitatory Amino Acid Antagonists; Flumazenil; GABA Modulators; GABAergic Neurons; Inflammation; Interneurons; Ketamine; Lipopolysaccharides; Long-Term Potentiation; Memory, Short-Term; Neural Inhibition; Open Field Test; Parvalbumins; Rats; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Sepsis-Associated Encephalopathy; Synaptic Transmission | 2020 |
GluN2A-selective positive allosteric modulator-nalmefene-flumazenil reverses ketamine-fentanyl-dexmedetomidine-induced anesthesia and analgesia in rats.
Topics: Adjuvants, Anesthesia; Allosteric Regulation; Analgesia; Anesthesia; Animals; Delayed Emergence from Anesthesia; Dexmedetomidine; Drug Combinations; Drug Evaluation, Preclinical; Female; Fentanyl; Flumazenil; GABA-A Receptor Antagonists; Ketamine; Male; Maze Learning; Naltrexone; Narcotic Antagonists; Nociception; Pain Measurement; Rats; Receptors, N-Methyl-D-Aspartate; Reflex, Righting; Rotarod Performance Test | 2020 |
Reversal effects of atipamezole, flumazenil, and 4-aminopyridine on bradycardia and increases in blood pressures induced by medetomidine, midazolam, and ketamine in isoflurane-anesthetized cats.
Topics: 4-Aminopyridine; Animals; Blood Pressure; Bradycardia; Cat Diseases; Cats; Flumazenil; Heart Rate; Imidazoles; Isoflurane; Ketamine; Medetomidine; Midazolam; Prospective Studies | 2022 |
Comparison of two injectable anaesthetic protocols in Egyptian fruit bats (Rousettus aegyptiacus) undergoing gonadectomy.
Topics: Anesthetics; Animals; Butorphanol; Castration; Chiroptera; Chlorides; Dexmedetomidine; Flumazenil; Hypnotics and Sedatives; Isoflurane; Ketamine; Midazolam; Sodium | 2022 |
Search for Novel Therapies for Essential Tremor Based on Positive Modulation of α6-Containing GABA
Topics: Animals; Essential Tremor; Flumazenil; gamma-Aminobutyric Acid; Harmaline; Humans; Ketamine; Mice; Mice, Knockout; Receptors, GABA-A; Tremor | 2023 |