flumazenil has been researched along with gamma-aminobutyric acid in 316 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 97 (30.70) | 18.7374 |
| 1990's | 80 (25.32) | 18.2507 |
| 2000's | 68 (21.52) | 29.6817 |
| 2010's | 56 (17.72) | 24.3611 |
| 2020's | 15 (4.75) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Avoni, P; Bonetti, EP; Cortelli, P; Gallassi, R; Lugaresi, A; Lugaresi, E; Montagna, P; Schoch, P; Sforza, E; Tinuper, P | 1 |
| Facklam, M; Haefely, WE; Schoch, P | 1 |
| Hood, KE; Miczek, KA; Miller, LG; Weerts, EM | 1 |
| Bureau, M; Delgado-Escueta, AV; Houser, CR; Möhler, H; Olsen, RW; Richards, JG | 1 |
| Davies, LP; Drew, CA; Duffield, P; Jamieson, DD; Johnston, GA | 1 |
| Bagust, J; Deacon, RM; Gardner, CR; Walker, RJ; Ward, RA | 1 |
| Barlin, GB; Davies, LP; Ireland, SJ; Ngu, MM | 1 |
| Bernasconi, R; Leonhardt, T; Martin, P; Portet, C; Schmutz, M; Steulet, AF | 1 |
| Carter, DB; Gale, W; Im, HK; Im, WB; Lennon, DJ; Ngo, DM; Seeburg, PH; Smith, MW; Thomsen, DR | 1 |
| Mehta, AK; Mhatre, M; Ticku, MK | 1 |
| Basile, AS; Harrison, PM; Hughes, RD; Jones, EA; Murata, Y; Pannell, L; Skolnick, P; Williams, R | 1 |
| Christensen, T; Diemer, NH; Jensen, CV; Jensen, MS; Johansen, FF; Lambert, JD; Nathan, T; Valente, E | 1 |
| Agmo, A; Fernández, H | 1 |
| Jones, EA | 1 |
| Bottlaender, M; Brouillet, E; Chavoix, C; Dodd, RH; Fournier, D; Hantraye, P; Khalili-Varasteh, M; Mazière, M | 1 |
| Gadek, M; Marczynski, TJ; Urbancic, M | 1 |
| Pleis, S; Thirlby, RC | 1 |
| Ichihara, K; Kameyama, T; Nabeshima, T; Tohyama, K | 1 |
| Airaksinen, MM; MacDonald, E; Rägo, L; Saano, V | 1 |
| Farb, DH; Friedman, L; Gibbs, TT; Roca, DJ; Rozenberg, I; Schiller, GD | 1 |
| Galpern, WR; Greenblatt, DJ; Lumpkin, M; Miller, LG; Shader, RI | 1 |
| Blakeman, DP; Im, WB | 1 |
| Ducić, I; Polc, P | 1 |
| Hicks, TP; Oka, JI | 1 |
| Cremades, A; Del Rio-Garcia, J | 1 |
| Kulkarni, SK; Sharma, AC | 1 |
| Blier, P; de Montigny, C; Lista, A | 1 |
| Borden, LA; Gibbs, TT | 1 |
| Kulkarni, SK; Ticku, MK | 1 |
| Danielou, G; Lloyd, GK; Thuret, F | 1 |
| Baldwin, RM; Innis, RB; Johnson, EW; McBride, BJ; Woods, SW; Zoghbi, S | 1 |
| Costa, E; Guidotti, A | 1 |
| Obata, T; Yamamura, HI | 1 |
| Havoundjian, H; Skolnick, P; Trullas, R | 1 |
| Baur, R; Sigel, E | 2 |
| Mehta, AK; Ticku, MK | 1 |
| Kovács, I; Maksay, G; Simonyi, M | 1 |
| Marczynski, TJ; Urbancic, M | 1 |
| Gallager, DW; Heninger, C; Hernandez, TD; Wilson, MA | 1 |
| Hellevuo, K; Kiianmaa, K; Korpi, ER | 1 |
| Gallager, DW; Wilson, MA | 2 |
| Baur, R; Peter, AB; Sigel, E; Yao, Y | 1 |
| Albertson, TE; Joy, RM | 1 |
| Barth, TM; Bowery, NG; Moratalla, R | 1 |
| Bechtel, WD; Ikeda, M; Malatynska, E; Weber, KH; Yamamura, HI | 1 |
| Porter, RJ | 1 |
| Akaike, N; Fukuda, T; Oyama, Y; Yakushiji, T | 1 |
| Cooper, SJ; Estall, LB | 1 |
| Green, S; Hodges, H | 1 |
| Cox, DH; Guidotti, A; Santi, MR | 1 |
| Farb, DH; Mierlak, D | 1 |
| McCabe, RT; Olsen, RW; Wamsley, JK; Yezuita, JP | 1 |
| Aranko, K; File, SE | 1 |
| Arbilla, S; Langer, SZ; Lista, A | 1 |
| Marley, RJ; Stinchcomb, A; Wehner, JM | 1 |
| Chivers, J; Horton, RW; Jenner, P; Lowther, S; Marsden, CD; Testa, B | 1 |
| Greentree, SG; Pertwee, RG; Swift, PA | 1 |
| Leidenheimer, NJ; Schechter, MD | 1 |
| Harris, C; Lal, H | 1 |
| Chan, CY; Farb, DH | 1 |
| Akhundov, RA; Rozhanets, VV; Val'dman, AV; Voronina, TA | 1 |
| Danchev, N | 1 |
| Koe, BK; Kondratas, E; Russo, LL | 1 |
| O'Regan, MH; Phillis, JW | 1 |
| Concas, A; Morelli, M; Obata, T; Serra, M; Yamamura, HI | 1 |
| De Deyn, PP; Macdonald, RL | 2 |
| Deutsch, SI; Greenblatt, DJ; Miller, LG; Paul, SM; Shader, RI | 1 |
| Fillenz, M; Fung, SC | 2 |
| Biggio, G; Concas, A; Corda, MG; Crisponi, G; Nurchi, V; Serra, M | 1 |
| Karobath, M; Supavilai, P | 1 |
| Rastogi, SK; Ticku, MK | 1 |
| Moura, D; Soares-da-Silva, P | 1 |
| Dingledine, R; King, GL; Knox, JJ | 1 |
| Cole, R; De Vellis, J; Noble, EP; Syapin, PJ | 1 |
| Meiners, BA; Salama, AI | 1 |
| Haefely, W; Möhler, H; Richards, JG; Schoch, P | 1 |
| Cohen, RM; Havoundjian, H; Paul, SM; Skolnick, P | 1 |
| Sweetnam, PM; Tallman, JF | 1 |
| Hicks, TP; Jang, EK; Oka, JI | 1 |
| Garcha, HS; Rose, IC; Stolerman, IP | 1 |
| Cottrell, GA; Lambert, JJ; Peters, JA | 1 |
| Adjeroud, S; Cazin, L; Danger, JM; Gouteux, L; Lamacz, M; Leneveu, E; Tonon, MC; Vaudry, H | 1 |
| Ciuffi, M; Franchi-Micheli, S; Luzzi, S; Rosi, E; Spagnesi, S; Zilletti, L | 1 |
| Dhawan, BN; Gulati, A; Singh, HK; Srimal, RC | 1 |
| Alho, H; Costa, E; Mienville, JM; Santi, MR; Vaccarino, FM; Vicini, S | 1 |
| Ferrario, P; Hafner, B; Mantegazza, P; Zambotti, F; Zecca, L; Zonta, N | 1 |
| Gallager, DW; Gonsalves, SF | 1 |
| Kataoka, Y; Kumakura, K; Ohara-Imaizumi, M; Ueki, S | 1 |
| Chiu, TH; Rosenberg, HC; Yu, O | 1 |
| Majewska, MD; Mienville, JM; Vicini, S | 1 |
| Macdonald, RL; Skerritt, JH | 2 |
| Villiger, JW | 1 |
| Braestrup, C; Honoré, T; Jensen, LH; Kehr, W; Petersen, EN; Schmiechen, R; Schneider, H; Seidelmann, D; Stephens, DN | 1 |
| Costa, E; Ferrari, M; Ferrero, P; Guidotti, A | 1 |
| Little, HJ | 1 |
| Brown, C; Martin, IL | 1 |
| Caputti, E; Cardinali, DP; Lowenstein, PR; Rosenstein, R | 1 |
| Moncada, VY; Paul, SM; Schweri, MM; Skolnick, P; Williams, EF | 1 |
| Chiu, TH; Rosenberg, HC | 1 |
| Chow, SC; Davies, LP; Johnston, GA; Skerritt, JH | 1 |
| Johnston, GA; Skerritt, JH | 1 |
| Bryere, P; Kaijima, M; Naquet, R; Valin, A | 1 |
| Costa, E | 1 |
| Haefely, W | 2 |
| Colombo, G; Glässer, A; Luzzani, F | 1 |
| Bovier, P; Broekkamp, CL; Lloyd, KG; Worms, P | 1 |
| Cowen, PJ; Little, HJ; Nutt, DJ | 1 |
| Corda, MG; Costa, E; Guidotti, A | 3 |
| Morag, M; Myslobodsky, M | 1 |
| Möhler, H | 1 |
| Allikmets, LH; Rägo, LK | 1 |
| Cooper, EC; Diamond, I; Gordon, A; Greenberg, DA | 1 |
| Grandison, L | 1 |
| Brown, CL; Martin, IL | 1 |
| Scholfield, CN | 1 |
| Schwarz, M; Sontag, KH; Turski, L | 1 |
| Blas, C; Ferron, A; Glowinski, J; Soubrie, P | 1 |
| Curtis, DR; Leah, JD; Malik, R | 1 |
| Geller, HM; Haas, H; Krespan, B; Springfield, SA | 1 |
| Levin, D; Morag, M; Myslobodsky, MS | 1 |
| Morgan, PF; Stone, TW | 1 |
| Niles, LP; Tenn, CC | 1 |
| Belachew, S; Kettenmann, H; Lefebvre, PP; Leprince, P; Malgrange, B; Moonen, G; Rigo, JM; Rogister, B | 1 |
| Carter, DB; Hamilton, BJ; Im, HK; Im, WB; Vonvoigtlander, PF | 1 |
| Harris, RA; Klein, RL; Whiting, PJ | 1 |
| Carter, DB; Gammill, RB; Hamilton, BJ; Im, HK; Im, WB; Judge, TM; Pregenzer, JF | 1 |
| Chang, CC; Chiou, LC | 1 |
| Cardinali, DP; Golombek, DA; Martini, M | 1 |
| Ito, M; Kishi, K; Mori, C; Shiraishi, H; Tsuda, A; Tsuda, H | 1 |
| Harris, RA; McQuilkin, SJ; Mihic, SJ; Whatley, VJ | 1 |
| Hu, XJ; Ticku, MK | 1 |
| Davies, MF; Loew, GH; Maguire, PA | 1 |
| Alastra, AJ; Cohen, C; Goldberg, SR; Marley, RJ; Sannerud, CA; Serdikoff, SL | 1 |
| Dorrington, KL; Nagyova, B; Robbins, PA | 1 |
| Akaike, N; Harata, N; Kameda, H; Kataoka, M; Sanjou, K; Takahashi, K | 1 |
| Emerich, DF; Stackman, RW; Taylor, LA; Walsh, TJ | 1 |
| Arban, R; Costa, E; Ducić, I; Giusti, P; Guidotti, A; Puia, G; Walser, A | 1 |
| Katz, JL; Skolnick, P; Witkin, JM; Wong, G | 1 |
| Wilson, MA | 1 |
| al-Tikriti, MS; Baldwin, RM; Bradberry, C; Bremner, JD; During, M; Malison, RT; Seibyl, JP; Sybirska, E; Zea-Ponce, Y; Zoghbi, S | 1 |
| Carlen, PL; Weiner, JL; Zhang, L | 1 |
| Howard, CD; Seifert, CF | 1 |
| Caruncho, HJ; Costa, E; Grayson, DR; Ikonomovic, S; Vicini, S; Zheng, TM; Zhu, WJ | 1 |
| Acri, JB; Barrett, JE; Gleeson, S; Witkin, JM; Wong, G | 1 |
| Biggio, G; Cuccheddu, T; Floris, S; Porceddu, ML; Sanna, E; Serra, M | 1 |
| Ambrogi, V; Giannaccini, G; Grandolini, G; Lucacchini, A; Martini, C; Perioli, L | 1 |
| Nakamura, F; Nishimura, S; Seino, M; Suzuki, S; Yagi, K | 1 |
| Brooks, DJ; Duncan, JS; Fish, DR; Koepp, MJ; Richardson, MP | 1 |
| Bottlaender, M; Brouillet, E; Fuseau, C; Mazière, M; Schmid, L | 1 |
| Aguayo, LG; Cisternas, C; Pancetti, FC; Tapia, JC | 1 |
| Hatta, S; Saito, T; Takahata, N; Toki, S | 1 |
| Busatto, GF; Costa, DC; David, AS; Ell, PJ; Kerwin, RW; Lucey, JV; Pilowsky, LS | 1 |
| Davies, PA; Hales, TG; Hanna, MC; Kirkness, EF | 1 |
| Bottlaender, M; Brouillet, E; Fournier, D; Fuseau, C; Mazière, M; Schmid, L | 1 |
| Matsumoto, K; Ojima, K; Watanabe, H | 1 |
| Covey, DF; Ferrendelli, JA; Krause, JE; Rothman, SM; Tucker, JB; Weiss, DS; White, G; Williams, KL | 1 |
| Dohi, S; Furuya, K; Ishizawa, Y; Yamagishi, S | 1 |
| Verhoeff, NP | 1 |
| Bell, CJ; Cunningham, VJ; Jones, T; Liddle, PF; Malizia, AL; Nutt, DJ | 1 |
| Del Río, J; Díez-Ariza, M; Lasheras, B; Ramírez, MJ | 1 |
| Katukov, VIu; Lesnichuk, SA; Porodenko, NV; Severin, ES | 1 |
| Atack, JR; McKernan, RM; Smith, AJ | 1 |
| File, SE; Gonzalez, LE; Ouagazzal, AM | 1 |
| Ahmad, F; Hammond, JB | 1 |
| Borea, PA; Dalpiaz, A; Gessi, S; Varani, K | 1 |
| Chiu, TH; Li, M; Rosenberg, HC; Walsh, LA; Zhao, TJ | 1 |
| García-Estañ, J; Hernández, J; Janvier, JJ | 1 |
| Gardner, CR; Pringle, AK; Walker, RJ | 1 |
| Baur, R; Buhr, A; Sigel, E | 1 |
| Brown, SD; Skeen, GA; White, HS; Wolf, HH; Woodhead, JH | 1 |
| Gillardin, J; Poisbeau, P; Rybalchenko, V; Schlichter, R; Verleye, M | 1 |
| Bottacchi, E; Corso, G; D'Alessandro, G | 1 |
| Savic, I | 1 |
| Amin, J; Hadley, SH; Morris, KD; Walters, RJ | 1 |
| Adamec, RE | 1 |
| Betti, L; Bistocchi, M; Giannaccini, G; Gori, M; Lucacchini, A | 1 |
| Paz, L; Peter, Y; Pick, CG; Weizman, R | 1 |
| Paz, L; Peter, Y; Pick, CG; Toren, P; Weizman, R | 1 |
| Kulkarni, SK; Naidu, PS; Raghavendra, V | 1 |
| Föhr, J; Husso-Saastamoinen, M; Könönen, M; Kuikka, JT; Lehtonen, J; Mervaala, E; Partanen, J; Tammi, AK; Tiihonen, J; Valkonen-Korhonen, M; Viinamäki, H | 1 |
| Fuentes, T; Galindo, A; García Estañ, J; Hernández, J; Vargas, ML | 1 |
| Atack, J; Banks, G; Kelly, MD; Maubach, KA; Seabrook, GR; Smith, A; Whiting, PW; Wingrove, P | 1 |
| Cho, J; Choi, HC; Ha, JH; Kang, BS; Lee, DU; Lee, KY; Lim, JC | 1 |
| Safo, P; Thompson, SA; Wafford, KA; Wheat, L; Whiting, PJ; Wingrove, PB | 1 |
| Choi, YM; Huh, IH; Jeong, JH; Lee, BC; Lee, SY; Min, YS; Sohn, UD | 1 |
| Benz, A; Covey, DF; Eisenman, LN; Fields, C; Fu, T; He, Y; Mathews, J; Mennerick, S; Steinbach, JH; Wang, M; Zeng, CM; Zorumski, CF; Zorumski, E | 1 |
| Hamann, M; Richter, A | 1 |
| Andjelković, DS; Bokonjić, DR; Obradović, DI; Savić, MM; Stojilković, MP; Ugresić, ND | 1 |
| Copolov, D; Dean, B; McLeod, M; Pralong, D | 1 |
| Beani, L; Bianchi, C; Cavallini, S; Ferraro, L; Marino, S; Rodi, D; Siniscalchi, A | 1 |
| Amsden, GW; Butler, TC; Rosen, RM; Wallace, AL | 1 |
| Andjelković, DS; Bokonjić, DR; Obradović, DI; Savić, MM; Ugresić, ND | 1 |
| Abraini, JH; Balon, N; Kriem, B; Risso, JJ; Rostain, JC | 1 |
| Bisbrown-Chippendale, R; Bullmore, ET; Dirckx, SG; Kerwin, RW; McKenna, PJ; Ooi, C; Pickard, JD; Stephenson, CM; Suckling, J | 1 |
| Anand, A; Baldwin, RM; Bozkurt, A; Charney, DS; Degen, K; Fujita, M; Innis, RB; Khan, SA; Kugaya, A; Mason, GF; Sanacora, G; Seibyl, JP; Seneca, NM; Verhoeff, NP; Zoghbi, SS | 1 |
| Baker, GB; Bell, EC; Bellavance, F; Khudabux, J; Le Mellédo, JM; Poag, C | 1 |
| Maruyama, K; Nakamura, S; Nishina, M; Suzuki, M | 1 |
| Chebib, M; Hall, BJ; Hanrahan, JR; Johnston, GA | 2 |
| Foster, AC; Grigoriadis, DE; Gross, RS; Petroski, RE; Sullivan, SK; Verge, G | 1 |
| Jembrek, MJ; Lazić, J; Pericić, D; Rajcan, I; Strac, DS | 1 |
| Forman, SA; Rüsch, D | 1 |
| Bernöster, K; Dost, R; Egerland, U; Langen, B; Rundfeldt, C; Unverferth, K | 1 |
| Carai, MA; Colombo, G; Gessa, GL | 1 |
| Dean, B; McLeod, M; Scarr, E | 1 |
| Boutros, NN; Cooper, T; D'Souza, DC; Donahue, L; Ebersole, JS; Gil, RB; Krystal, JH; MacDougall, LM; Seibyl, J; Zuzarte, E | 1 |
| Baburin, I; Hering, S; Hohaus, A; Khom, S; Sieghart, W; Timin, EN | 1 |
| Hirano, S; Kamei, J; Miyata, S | 1 |
| Kulkarni, SK; Kumar, A | 1 |
| Hanchar, HJ; Olsen, RW; Wallner, M | 1 |
| Hashizume, K; Hodozuka, A; Tanaka, T; Tsuda, H | 1 |
| Otto, JF; Simeone, TA; White, HS; Wilcox, KS | 1 |
| Bullmore, E; Fletcher, P; Kamath, S; McKenna, P; Menzies, L; Ooi, C; Stephenson, C; Suckling, J | 1 |
| Chen, L; Fung, KS; Xie, JX; Yung, WH | 1 |
| Jembrek, MJ; Pericić, D; Strac, DS; Vlainić, J | 1 |
| Chu, QP; Cui, XY; Fu, HZ; Lin, SQ; Lin, ZB; Wang, LE; Zhang, YH | 1 |
| Biggio, F; Caria, S; Follesa, P; Gorini, G; Murru, L; Sanna, E | 1 |
| Cho, YW; Jang, CG; Jin, C; Jung, JW; Lee, JJ; Oh, TH; Ryu, JH; Yoon, BH | 1 |
| Baburin, I; Hering, S; Hohaus, A; Khom, S; Kopp, B; Timin, E; Trauner, G | 1 |
| Baron, M; Gromov, I; Hanselka, LL; Urschel, HC; White, L | 1 |
| Leal, L; Pinerua-Shuhaibar, L; Quintero, L; Silva, JA; Suarez-Roca, H | 1 |
| Nassiri-Asl, M; Shariati-Rad, S; Zamansoltani, F | 1 |
| Amemiya, S; Hamamoto, M; Katayama, Y; Kumagai, T; Mishina, M; Nishiyama, Y; Ueda, M | 1 |
| Basile, A | 1 |
| Cho, RY; Frankle, WG; Lewis, DA; Litschge, M; Mason, NS; Mathis, CA; Narendran, R; Price, JC; Vora, S | 1 |
| Canto-de-Souza, A; dos Reis, LM | 1 |
| Chebib, M; Fernandez, SP; Hanrahan, JR; Johnston, GA; Mewett, KN | 1 |
| Andrzej, P; Brañski, P; Cryan, JF; Flor, PJ; Kłak, K; Stachowicz, K; van der Putten, H | 1 |
| Keist, R; Pearce, RA; Rudolph, U; Zarnowska, ED | 1 |
| Bostwick, R; Chen, T; Huston, J; Knappenberger, K; Liu, J; Norris, T; Wood, M | 1 |
| Butterweck, V; Grundmann, O; Kamata, K; Nakajima, J; Seo, S | 1 |
| Kłodzińska, A; Neuville, P; Palucha-Poniewiera, A; Pilc, A; Schann, S; Stachowicz, K | 1 |
| de Aquino Neto, MR; de Lavor, EP; de Sousa, DP; de Sousa, FC; de Sousa, HL; de Vasconcelos, PF; Macêdo, DS; Moura, BA; Silva, MA; Silva, MI; Vasconcelos, SM | 1 |
| Anton, RF; Baros, AM; Latham, PK; Malcolm, R; Myrick, H; Randall, PK; Stewart, SH; Waid, R; Wright, TM | 1 |
| Butman, J; Carson, R; Dustin, I; Forester, K; Gibson, KM; Herscovitch, P; Jakobs, C; Liew, C; Pearl, PL; Quezado, Z; Reeves-Tyer, P; Schreiber, J; Shamim, S; Taylor, J; Theodore, W; Trzcinski, S | 1 |
| Baur, R; Charon, S; Goeldner, M; Sigel, E; Tan, KR | 1 |
| Boellaard, R; Comans, EF; Drent, ML; Hoogendijk, WJ; Klumpers, UM; Lammertsma, AA; Meynen, G; Veltman, DJ | 1 |
| Dodd, PR; Renshaw, GM; Wise, G | 1 |
| Adelson, PD; Dixon, CE; Fellows-Mayle, W; Hsieh, LB; Ochalski, PG; Okonkwo, DO; Srinivas, R | 1 |
| Baron, M; Hanselka, LL; Urschel, HC | 1 |
| Boecker, H; Brooks, DJ; Ceballos-Baumann, AO; Liedtke, C; Miederer, I; Miederer, M; Sprenger, T; Wagner, KJ; Weindl, A | 1 |
| Acher, F; Brański, P; Pałucha-Poniewiera, A; Pilc, A; Stachowicz, K; Wierońska, JM | 1 |
| Ernst, M; Furtmüller, R; Ramerstorfer, J; Sarto-Jackson, I; Sieghart, W; Varagic, Z | 1 |
| Dirkx, R; Folli, F; Geis, C; Gerlach, M; Grünewald, B; Heckmann, M; Perani, D; Reif, A; Solimena, M; Sommer, C; Toyka, KV; Weishaupt, A; Wultsch, T | 1 |
| Kumar, A; Kumar, P; Singh, A | 1 |
| Anton, RF; Baros, AM; Latham, PK; Myrick, H; Randall, PK; Schacht, JP; Waid, LR; Wright, TM | 1 |
| Cardenas, R; Quintero, L; Suarez-Roca, H | 1 |
| Chebib, M; Gavande, N; Hanrahan, JR; Johnston, GA; Karim, N; Wellendorph, P | 1 |
| Fujii, E; Harada, M; Kagami, S; Miyazaki, M; Mori, K; Mori, T; Toda, Y | 2 |
| Annon, J; Bholat, MA; Charuvastra, C; Chim, D; Doraimani, G; Dowling, PT; Heinzerling, K; Hillhouse, M; Ling, W; Shoptaw, S | 1 |
| Fujii, E; Harada, M; Hashimoto, T; Kagami, S; Miyazaki, M; Mori, K; Mori, T; Toda, Y | 1 |
| Fujii, T; Higashi, T; Kumada, T; Miyajima, T; Nishii, R; Oda, N; Saito, K; Shimomura, H | 1 |
| Chen, CM; Cho, RY; Frankle, WG; Himes, M; Lewis, DA; Mason, NS; Mathis, CA; Narendran, R; Walker, C | 1 |
| Abbasi, E; Nassiri-Asl, M; Shafeei, M; Sheikhi, M | 1 |
| Bagic, A; Bonne, O; Carson, RE; Drevets, WC; Hallett, M; Herscovitch, P; Kazuba, D; Lerner, A; Mari, Z; Murphy, DL; Simmons, JM; Xu, B | 1 |
| Figueiras, FP; Gironell, A; Gispert, JD; Herance, JR; Pagonabarraga, J; Pascual-Sedano, B; Trampal, C | 1 |
| Ebihara, S; Imai, S; Mamiya, T; Mouri, A; Nabeshima, T; Sakai, Y; Tsukada, A | 1 |
| Dabole, B; Dawe, A; De Waard, M; Dimo, T; Djomeni Dzeufiet, PD; Ngo Bum, E; Okomolo Moto, FC; Sidiki, N; Sotoing Taïwe, G; Talla, E; Temkou Ngoupaye, G | 1 |
| Bajbouj, M; Duncan, NW; Gravel, P; Hayes, DJ; Kostikov, AP; Lyttelton, O; Northoff, G; Qin, P; Reader, AJ; Schirrmacher, R; Verhaeghe, J; Wiebking, C | 1 |
| Ambrosino, P; Annunziato, L; Bonanno, G; Caliendo, G; Cantile, M; Cuomo, O; Di Renzo, G; Fiorino, F; Gatta, E; Milanese, M; Molinaro, P; Pannaccione, A; Pignataro, G; Robello, M; Santagada, V; Scorziello, A; Secondo, A; Severino, B; Sisalli, MJ | 1 |
| Kim, JS; Kim, KK; Kim, MJ; Lim, YM | 1 |
| Brito, GA; Cavalheiro, EA; da Costa, MA; da Cruz, GM; da Graça Naffah-Mazzacoratti, M; de Andrade, GM; de Barros Viana, GS; Felipe, CF; Leal, LK; Menezes, ML; Scorza, FA; Tavares, AF | 1 |
| Anton, RF; Henderson, S; Li, X; Myrick, H; Randall, PK; Schacht, JP | 1 |
| An, SK; Kang, JI; Kim, KR; Kim, SJ; Kwon, JS; Lee, E; Lee, JD; Lee, SY; Park, HJ | 1 |
| Antonini, A; Caioli, S; Guglielmotti, A; Pieri, M; Severini, C; Zona, C | 1 |
| Cho, S; Han, D; Jin, YH; Jin, Z; Kim, IH; Kim, S | 1 |
| Carson, RE; Castner, SA; Cosgrove, K; Fowles, K; Huang, Y; Jin, X; Labaree, D; Mulnix, T; Rabiner, EA; Ropchan, J; Sandiego, CM; Wells, L; Williams, GV | 1 |
| Carson, RE; Jin, X; Mulnix, T; Sandiego, CM | 1 |
| Ishola, IO; Olayemi, SO; Umeh, EA; Yemitan, OK | 1 |
| Fang, N; Guo, JY; Li, J; Liu, GL; Liu, J; Liu, QT; Shi, JL; Yang, YX; Zhai, WM | 1 |
| Bois, F; Cahill, J; Carbuto, M; Cortes-Briones, J; D'Souza, DC; Gunduz-Bruce, H; Pittman, B; Radhakrishnan, R; Ranganathan, M; Schnakenberg, A; Sewell, RA; Skosnik, PD | 1 |
| Hall, SD; Jones, RS; Ladds, G; Prokic, EJ; Stanford, IM; Weston, C; Woodhall, GL; Yamawaki, N | 1 |
| Ahn, KH; D'Souza, DC; Elander, J; Gunduz-Bruce, H; Krystal, J; Pittman, B; Ranganathan, M; Sewell, A | 1 |
| Baur, R; Maldifassi, MC; Middendorp, SJ; Sigel, E | 1 |
| Basso, MR; Hood, S; Hulse, G; Kelty, E; Norman, A; Reece, AS | 1 |
| Cho, RY; Frankle, WG; Himes, ML; Lewis, DA; Mason, NS; Narendran, R; Paris, J; Prasad, KM; Walker, C | 1 |
| Allio, A; Calorio, C; Carbone, E; Franchino, C; Gavello, D; Marcantoni, A | 1 |
| Chen, K; Han, LW; Ji, H; Sun, JH; Wang, ZQ; Wei, TT | 1 |
| Bouet, R; Bouvard, S; Ciumas, C; Jerbi, K; Jung, J; Kujala, J; Lecaignard, F; Lothe, A; Ryvlin, P | 1 |
| Kuver, A; Smith, SS | 1 |
| Banks, ML; Shelton, KL; Tracy, ME | 1 |
| Groundwater, PW; Hamid, K; Hanrahan, J; Hibbs, DE; Ng, I; Tallapragada, VJ | 1 |
| Abrunhosa, AJ; Bernardino, I; Castelo-Branco, M; Ferreira, N; Patricio, M; Rebola, J; Violante, IR | 1 |
| Raines, DE | 1 |
| Deng, S; Ding, J; Fan, HR; Ge, WH; Huang, C; Li, F; Li, WG; Liu, YM; Xu, TL; Zhu, T | 1 |
| Antoni, FA; Barkóczy, J; Belelli, D; Brown, AR; Etherington, LA; Gacsályi, I; Gunn, BG; Kertész, S; Lambert, JJ; Ling, I; Livesey, MR; Mihalik, B; Monteiro, O; Pallagi, K; Pálvölgyi, A; Spedding, M; Varga, P | 1 |
| Barbosa-Filho, JM; Chaves, EMC; Dantas, LP; Honório-Júnior, JER; Lúcio, ASSC; Monteiro, VS; Nonato, DTT; Patrocínio, MCA; Sousa, CNS; Vasconcelos, SMM; Viana, GSB | 1 |
| Chen, CJ; Chen, DY; Duncan, NW; Huang, LK; Huang, Z; Lane, TJ; Lin, CE; Northoff, G; Qin, P; Wiebking, C; Yang, CM | 1 |
| Hibbs, RE; Kim, JJ; Noviello, CM; Teng, J; Walsh, RM; Zhu, S | 1 |
| Andersson, JD; Finnema, SJ; Matuskey, D | 1 |
| Jin, Y; Li, Y; Liu, Y; Sun, F; Yang, S; Zhang, J; Zhou, J; Zhu, K | 1 |
| Gharpure, A; Hibbs, RE; Howard, RJ; Kim, JJ; Lindahl, E; Noviello, CM; Teng, J; Walsh, RM; Zhu, S; Zhuang, Y | 1 |
| Cho, KIK; Jeong, JM; Kim, E; Kim, M; Kwon, JS; Lee, J; Lee, JS; Lee, TY; Seo, S; Yoon, YB | 1 |
| Cao, Y; Lian, J; Ma, Y; Muheyati, A; Su, R; Wang, N; Yu, G; Yuan, S; Zhang, S | 1 |
| Gallo, AT; Hulse, GK | 1 |
| Danton, O; Faleschini, MT; Garifulina, A; Gupta, MP; Hamburger, M; Hering, S; Syafni, N | 1 |
| Arnold, LA; Emala, CW; Perez-Zoghbi, JF; Sajorda, DR; Webb, DA; Yocum, GT | 1 |
| Chen, D; Guo, W; Hu, H; Jiang, W; Li, J; Li, Y; Liu, H; Mu, K; Ning, N; Yu, X; Zhang, C; Zheng, J; Zhou, Y | 1 |
| Ali, I; Haskali, MB; Hutton, CA; Jupp, B; O'Brien, TJ; Roselt, PD; Vivash, L | 1 |
| Chai, X; Chen, S; Gao, X; Huang, L; Jiao, S; Li, J; Ma, X; Tu, P; Wuken, S | 1 |
| Hajizadeh Moghaddam, A; Mashayekhpour, MA; Tabari, MA | 1 |
| Ahmed, T; Al-Khafaji, K; Araújo, IM; Bappi, MH; Coutinho, HDM; de Andrade, EM; Hanif, MA; Hossain, R; Islam, MS; Islam, MT; Khan, RA; Kowalska, G; Kowalski, R; Rahaman, MM; Sarkar, C | 1 |
| Brandt, AL; Freeman, AAH; Jenkins, A; Kaplan, A; Lewicki, LG; Nash, AI; Rye, DB; Trotti, LM | 1 |
| Aburass, H; Alfaqih, H; Ardianto, C; Ayoub, R; Goh, KW; Jarrar, Q; Jarrar, Y; Ming, LC; Moshawih, S | 1 |
| Ernst, M; Handforth, A; Singh, RP; Treven, M | 1 |
15 review(s) available for flumazenil and gamma-aminobutyric acid
| Article | Year |
|---|---|
Endogenous ligands for benzodiazepine recognition sites.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Binding Sites; Binding, Competitive; Brain; Caffeine; Carrier Proteins; Chlorides; Conflict, Psychological; Diazepam Binding Inhibitor; Flumazenil; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; Hypoxanthine; Hypoxanthines; Inosine; Ion Channels; Membrane Proteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neuroglia; Neurons; Niacinamide; Organic Anion Transporters; Peptides; Phosphorylation; Protein Conformation; Protein Precursors; Receptors, GABA-A; Synaptic Membranes; Tissue Distribution; Trypsin | 1985 |
Behavioural pharmacology of food, water and salt intake in relation to drug actions at benzodiazepine receptors.
Topics: Animals; Anti-Anxiety Agents; Appetite; Appetite Depressants; Benzodiazepines; Benzodiazepinones; Carbolines; Chlordiazepoxide; Chlorides; Choice Behavior; Diazepam; Drinking Behavior; Feeding Behavior; Flumazenil; Food Deprivation; Food Preferences; gamma-Aminobutyric Acid; Ion Channels; Midazolam; Picrotoxin; Punishment; Pyrazoles; Receptors, GABA-A; Satiation; Sodium Chloride; Species Specificity | 1985 |
The role of adenosine in the central actions of the benzodiazepines.
Topics: Adenosine; Animals; Anti-Anxiety Agents; Arousal; Benzodiazepinones; Brain; Carbolines; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Neural Inhibition; Neurons; Purkinje Cells; Rats; Receptors, GABA-A | 1988 |
[Drug activation of GABAergic transmission in the central nervous system: benzodiazepines and GABAergic agonists].
Topics: Animals; Benzodiazepines; Benzodiazepinones; Brain; Carbolines; Chemical Phenomena; Chemistry; Cyclic GMP; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Humans; Receptors, GABA-A; Synaptic Transmission; Valproic Acid | 1985 |
Benzodiazepine receptors resolved.
Topics: Animals; Antibodies, Monoclonal; Autoradiography; Benzodiazepines; Benzodiazepinones; Bicuculline; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Chlorides; Clonazepam; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Histocytochemistry; Humans; Immunologic Techniques; Ionophores; Muscimol; Neurons; Radioisotopes; Radioligand Assay; Receptors, GABA-A; Spinal Cord; Synapses; Tissue Distribution | 1986 |
Antagonists of benzodiazepines.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Binding, Competitive; Carbolines; Flumazenil; gamma-Aminobutyric Acid; Humans; Models, Chemical; Molecular Conformation; Pyrazoles; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Neurotransmitter; Synaptic Transmission | 1983 |
Benzodiazepine receptors: mode of interaction of agonists and antagonists.
Topics: Affinity Labels; Animals; Benzodiazepines; Benzodiazepinones; Carbolines; Clonazepam; Drug Interactions; Flumazenil; gamma-Aminobutyric Acid; Ligands; Models, Biological; Receptors, Cell Surface; Receptors, GABA-A; Terminology as Topic; Thermodynamics | 1983 |
On a brain polypeptide functioning as a putative effector for the recognition sites of benzodiazepine and beta-carboline derivatives.
Topics: Animals; Benzodiazepinones; Brain Chemistry; Carbolines; Carrier Proteins; Chlorides; Flumazenil; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; Ionophores; Ligands; Membrane Proteins; Membrane Transport Proteins; Nerve Tissue Proteins; Organic Anion Transporters; Peptides; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Actions of benzodiazepines on the neuroendocrine system.
Topics: Adrenocorticotropic Hormone; Animals; Benzodiazepines; Benzodiazepinones; Flumazenil; gamma-Aminobutyric Acid; Growth Hormone; In Vitro Techniques; Pituitary Hormones, Anterior; Prolactin; Rats; Thyrotropin | 1983 |
Flumazenil in the treatment of hepatic encephalopathy.
Topics: Clinical Trials as Topic; Flumazenil; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Humans | 1993 |
Hepatic encephalopathy and role of antibenzodiazepines.
Topics: Flumazenil; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Humans; Severity of Illness Index | 1998 |
PET: central benzodiazepine neuroreceptor mapping in generalized epilepsies.
Topics: Cerebral Cortex; Epilepsy, Generalized; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Humans; Receptors, GABA-A; Thalamus; Tomography, Emission-Computed | 2000 |
Novel Indications for Benzodiazepine Antagonist Flumazenil in GABA Mediated Pathological Conditions of the Central Nervous System.
Topics: Animals; Central Nervous System; Central Nervous System Diseases; Flumazenil; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Inappropriate Prescribing; Off-Label Use; Patient Safety; Practice Patterns, Physicians'; Risk Assessment; Risk Factors; Treatment Outcome | 2015 |
Positron emission tomography imaging of the γ-aminobutyric acid system.
Topics: Animals; Benzodiazepines; Brain; Carbon Radioisotopes; Flumazenil; Fluorine Radioisotopes; gamma-Aminobutyric Acid; Humans; Ligands; Mental Disorders; Positron-Emission Tomography; Receptors, GABA-A | 2019 |
Clerodane Diterpenes from
Topics: Animals; Benzodiazepines; Casearia; CHO Cells; Cricetinae; Cricetulus; Diterpenes, Clerodane; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Oocytes; Receptors, GABA-A; Xenopus laevis | 2022 |
12 trial(s) available for flumazenil and gamma-aminobutyric acid
| Article | Year |
|---|---|
GABAergic inhibitory mechanisms for repetition-adaptivity in large-scale brain systems.
Topics: Adult; Arousal; Brain Mapping; Cerebral Cortex; Double-Blind Method; Female; Flumazenil; GABA Agonists; gamma-Aminobutyric Acid; Habituation, Psychophysiologic; Humans; Image Enhancement; Image Processing, Computer-Assisted; Lorazepam; Magnetic Resonance Imaging; Male; Memory, Short-Term; Middle Aged; Neural Inhibition | 2003 |
Response to flumazenil in the late luteal phase and follicular phase of the menstrual cycle in healthy control females.
Topics: Adult; Double-Blind Method; Female; Flumazenil; Follicular Phase; GABA Modulators; gamma-Aminobutyric Acid; Humans; Luteal Phase; Panic Disorder; Receptors, GABA-A | 2004 |
gamma-Aminobutyric acid-serotonin interactions in healthy men: implications for network models of psychosis and dissociation.
Topics: Analysis of Variance; Anxiety; Cross-Over Studies; Dissociative Disorders; Double-Blind Method; Drug Synergism; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Humans; Male; Models, Neurological; Perceptual Disorders; Piperazines; Psychoses, Substance-Induced; Receptors, GABA-A; Receptors, Serotonin, 5-HT2; Reference Values; Serotonin; Serotonin Receptor Agonists | 2006 |
Effects of gamma-aminobutyric acid-modulating drugs on working memory and brain function in patients with schizophrenia.
Topics: Adult; Brain; Cerebral Cortex; Cognition Disorders; Double-Blind Method; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Humans; Interneurons; Lorazepam; Magnetic Resonance Imaging; Male; Memory; Middle Aged; Models, Neurological; Neural Pathways; Neuropsychological Tests; Placebos; Schizophrenia; Schizophrenic Psychology; Synaptic Transmission | 2007 |
Efficacy of a combination of flumazenil and gabapentin in the treatment of alcohol dependence: relationship to alcohol withdrawal symptoms.
Topics: Administration, Oral; Adult; Alcohol Drinking; Alcoholism; Amines; Cyclohexanecarboxylic Acids; Double-Blind Method; Drug Therapy, Combination; Female; Flumazenil; GABA Modulators; Gabapentin; gamma-Aminobutyric Acid; Humans; Infusions, Intravenous; Logistic Models; Male; Medication Adherence; Middle Aged; Patient Selection; Sleep; Substance Withdrawal Syndrome; Temperance; Time Factors; Treatment Outcome | 2009 |
Reduced parahippocampal and lateral temporal GABAA-[11C]flumazenil binding in major depression: preliminary results.
Topics: Adult; Antidepressive Agents; Carbon Radioisotopes; Case-Control Studies; Corticotropin-Releasing Hormone; Depressive Disorder, Major; Dexamethasone; Female; Flumazenil; gamma-Aminobutyric Acid; Humans; Male; Neurosecretory Systems; Parahippocampal Gyrus; Protein Binding; Receptors, GABA-A; Treatment Outcome | 2010 |
A controlled trial of flumazenil and gabapentin for initial treatment of methylamphetamine dependence.
Topics: Adolescent; Adult; Amines; Amphetamine-Related Disorders; Anticonvulsants; Behavior, Addictive; Cyclohexanecarboxylic Acids; Double-Blind Method; Drug Therapy, Combination; Female; Flumazenil; GABA Modulators; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Patient Compliance | 2011 |
Neurocognitive performance, alcohol withdrawal, and effects of a combination of flumazenil and gabapentin in alcohol dependence.
Topics: Adult; Alcohol Drinking; Alcoholism; Amines; Cognition; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Female; Flumazenil; Gabapentin; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Male; Middle Aged; Recurrence; Substance Withdrawal Syndrome; Treatment Outcome | 2011 |
Double-blind placebo-controlled evaluation of the PROMETA™ protocol for methamphetamine dependence.
Topics: Adult; Amines; Amphetamine-Related Disorders; Cyclohexanecarboxylic Acids; Double-Blind Method; Drug Combinations; Female; Flumazenil; GABA Modulators; Gabapentin; gamma-Aminobutyric Acid; Histamine Agonists; Humans; Hydroxyzine; Infusions, Intravenous; Male; Medication Adherence; Methamphetamine; Self Report | 2012 |
Effects of a GABA-ergic medication combination and initial alcohol withdrawal severity on cue-elicited brain activation among treatment-seeking alcoholics.
Topics: Adult; Alcohol Drinking; Alcoholism; Amines; Brain; Cues; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Female; Flumazenil; Follow-Up Studies; GABA Modulators; Gabapentin; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Secondary Prevention; Severity of Illness Index; Substance Withdrawal Syndrome; Treatment Outcome | 2013 |
GABA Deficits Enhance the Psychotomimetic Effects of Δ9-THC.
Topics: Adolescent; Adult; Brain Mapping; Dissociative Disorders; Double-Blind Method; Dronabinol; Electroencephalography; Event-Related Potentials, P300; Flumazenil; gamma-Aminobutyric Acid; Humans; Male; Pain Measurement; Psychiatric Status Rating Scales; Psychotic Disorders; Psychotropic Drugs; Young Adult | 2015 |
Role of GABA Deficit in Sensitivity to the Psychotomimetic Effects of Amphetamine.
Topics: Adolescent; Adult; Amphetamine; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Flumazenil; gamma-Aminobutyric Acid; Hallucinogens; Healthy Volunteers; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Psychotic Disorders; Time Factors; Visual Analog Scale; Young Adult | 2015 |
289 other study(ies) available for flumazenil and gamma-aminobutyric acid
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Idiopathic recurring stupor: a case with possible involvement of the gamma-aminobutyric acid (GABA)ergic system.
Topics: Benzodiazepines; Coma; Electroencephalography; Flumazenil; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Recurrence; Unconsciousness | 1992 |
Relationship between benzodiazepine receptor occupancy and potentiation of gamma-aminobutyric acid-stimulated chloride flux in vitro of four ligands of differing intrinsic efficacies.
Topics: Animals; Benzodiazepinones; Cell Membrane; Cerebral Cortex; Chlorides; Diazepam; Drug Synergism; Flumazenil; gamma-Aminobutyric Acid; Ligands; Male; Rats; Receptors, GABA-A; Triazolam | 1992 |
Increased GABAA-dependent chloride uptake in mice selectively bred for low aggressive behavior.
Topics: Aggression; Animals; Chlorides; Flumazenil; gamma-Aminobutyric Acid; Genetics, Behavioral; Male; Mice; Mice, Inbred ICR; Phenotype; Receptors, GABA-A | 1992 |
GABA/benzodiazepine receptors in human focal epilepsy.
Topics: Amygdala; Autoradiography; Brain Mapping; Dominance, Cerebral; Electroencephalography; Epilepsies, Partial; Epilepsy, Complex Partial; Evoked Potentials; Flumazenil; gamma-Aminobutyric Acid; Hippocampus; Humans; Neural Inhibition; Neurons; Receptors, GABA-A; Temporal Lobe | 1992 |
Kava pyrones and resin: studies on GABAA, GABAB and benzodiazepine binding sites in rodent brain.
Topics: Animals; Benzodiazepines; Binding Sites; Brain; Flumazenil; gamma-Aminobutyric Acid; Kava; Ligands; Male; Mice; Mice, Inbred BALB C; Plant Extracts; Plants, Medicinal; Pyrones; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Resins, Plant; Synaptosomes | 1992 |
Effects of RU33368, a low affinity ligand for neuronal benzodiazepine receptors, on rodent behaviours and GABA-mediated synaptic transmission in rat cerebellar slices.
Topics: Animals; Behavior, Animal; Cerebellum; Conflict, Psychological; Flumazenil; gamma-Aminobutyric Acid; In Vitro Techniques; Ligands; Oxadiazoles; Pyrimidines; Rats; Rats, Wistar; Receptors, GABA-A; Stress, Psychological; Synapses; Synaptic Transmission | 1992 |
Substituted imidazo[1,2-b]pyridazines. New compounds with activity at central and peripheral benzodiazepine receptors.
Topics: Animals; Anti-Anxiety Agents; Binding, Competitive; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Imidazoles; Mice; Prosencephalon; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1992 |
Effects of benzodiazepine receptor ligands with different intrinsic activities on seizures induced by inhibition of GAD.
Topics: Animals; Anti-Anxiety Agents; Carbolines; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hippocampus; Isoniazid; Male; Mice; Mice, Inbred Strains; Pyrazoles; Reaction Time; Receptors, GABA-A; Seizures | 1992 |
Functional expression of GABAA chloride channels and benzodiazepine binding sites in baculovirus infected insect cells.
Topics: Animals; Baculoviridae; Benzodiazepinones; Binding Sites; Cell Line; Cell Membrane; Chloride Channels; DNA; Electrophysiology; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Membrane Proteins; Moths; Rats; Receptors, GABA-A; Transfection | 1992 |
Modulation of GABAergic transmission by ethanol.
Topics: Animals; Anticonvulsants; Azides; Benzodiazepines; Brain Chemistry; Ethanol; Female; Flumazenil; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Ion Channels; Male; Mice; Mice, Inbred C57BL; Pentylenetetrazole; Rats; Rats, Inbred Strains; RNA, Messenger; Seizures; Synaptic Transmission | 1992 |
Elevated brain concentrations of 1,4-benzodiazepines in fulminant hepatic failure.
Topics: Adult; Aged; Benzodiazepines; Brain Chemistry; Chromatography; Diazepam; Flumazenil; Frontal Lobe; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Humans; Mass Spectrometry; Middle Aged; Nordazepam; Receptors, GABA-A; Synaptic Transmission | 1991 |
Inhibition in postischemic rat hippocampus: GABA receptors, GABA release, and inhibitory postsynaptic potentials.
Topics: Animals; Autoradiography; Brain Ischemia; Dialysis; Electrophysiology; Flumazenil; gamma-Aminobutyric Acid; Hippocampus; Male; Membrane Potentials; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synapses | 1991 |
Benzodiazepine receptor ligands and sexual behavior in the male rat: the role of GABAergic mechanisms.
Topics: Animals; Bicuculline; Carbolines; Chlordiazepoxide; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Male; Motor Activity; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sexual Behavior, Animal | 1991 |
Benzodiazepine receptor ligands and hepatic encephalopathy: further unfolding of the GABA story.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Brain; Central Nervous System; Flumazenil; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Humans; Ligands; Neurons; Receptors, GABA-A; Synaptic Transmission | 1991 |
In vivo bidirectional modulatory effect of benzodiazepine receptor ligands on GABAergic transmission evaluated by positron emission tomography in non-human primates.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Carbolines; Cerebral Cortex; Diazepam; Electroencephalography; Flumazenil; gamma-Aminobutyric Acid; Ligands; Male; Papio; Pentylenetetrazole; Receptors, GABA-A; Seizures; Synaptic Transmission; Tomography, Emission-Computed | 1991 |
Chronic administration of flumazenil (Ro 15-1788) enhances non-appetitive exploratory behavior of rats.
Topics: Animals; Brain Chemistry; Defecation; Exploratory Behavior; Flumazenil; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Ligands; Male; Memory; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stimulation, Chemical; Urination | 1991 |
gamma-Aminobutyric acid and gastric acid secretion: a physiologic role?
Topics: Aminooxyacetic Acid; Animals; Bethanechol; Bethanechol Compounds; Female; Flumazenil; gamma-Aminobutyric Acid; Gastric Acid; Injections, Intravenous; Rats; Reference Values; Vagotomy | 1991 |
Involvement of GABAergic systems in benzodiazepine-induced impairment of passive avoidance learning in mice.
Topics: Animals; Anti-Anxiety Agents; Avoidance Learning; Bicuculline; Chlordiazepoxide; Drug Interactions; Flumazenil; GABA Antagonists; gamma-Aminobutyric Acid; Male; Memory; Mice; Mice, Inbred Strains; Muscimol; Picrotoxin | 1991 |
The effect of medetomidine on GABA and benzodiazepine receptors in vivo: lack of anxiolytic but some evidence of possible stress-protective activity.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Bicuculline; Brain; Cerebral Cortex; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Imidazoles; Kidney; Male; Medetomidine; Muscimol; Myocardium; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Stimulation, Chemical; Stress, Physiological; Tritium | 1991 |
gamma-Aminobutyric acidA receptor regulation in culture: altered allosteric interactions following prolonged exposure to benzodiazepines, barbiturates, and methylxanthines.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Allosteric Regulation; Animals; Barbital; Barbiturates; Brain; Caffeine; Cells, Cultured; Chick Embryo; Flumazenil; Flunitrazepam; Flurazepam; gamma-Aminobutyric Acid; Kinetics; Neurons; Pentobarbital; Receptors, GABA-A; Tetrodotoxin; Theophylline; Veratridine | 1990 |
Modification of gamma-aminobutyric acidA receptor binding and function by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline in vitro and in vivo: effects of aging.
Topics: Aging; Animals; Benzodiazepines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Cerebral Cortex; Dose-Response Relationship, Drug; Flumazenil; gamma-Aminobutyric Acid; Kinetics; Lorazepam; Male; Mice; Mice, Inbred Strains; Quinolines; Receptors, GABA-A | 1991 |
Correlation between gamma-aminobutyric acidA receptor ligand-induced changes in t-butylbicyclophosphoro[35S]thionate binding and 36Cl- uptake in rat cerebrocortical membranes.
Topics: Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Cerebral Cortex; Chloride Channels; Chlorides; Desoxycorticosterone; Diazepam; Ethanol; Flumazenil; gamma-Aminobutyric Acid; In Vitro Techniques; Ligands; Membrane Proteins; Pentobarbital; Pregnanolone; Rats; Receptors, GABA-A; Synaptosomes | 1991 |
Afferent stimulation frequency modulates GABAergic phenomena in the spinal cord: reversal by benzodiazepine antagonists.
Topics: Afferent Pathways; Animals; Benzodiazepines; Benzodiazepinones; Cats; Electric Stimulation; Flumazenil; gamma-Aminobutyric Acid; Ganglia, Spinal; Muscles; Receptors, GABA-A; Reflex; Spinal Cord; Synapses | 1990 |
Benzodiazepines and synaptic processing in the spatial domain within the cat's primary somatosensory cortex.
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Cats; Diazepam; Electric Stimulation; Electrophysiology; Female; Flumazenil; Fluphenazine; gamma-Aminobutyric Acid; Male; Midazolam; Physical Stimulation; Somatosensory Cortex; Space Perception; Synapses | 1990 |
GABAergic mechanisms in morphine-induced hypothermia.
Topics: 4-Aminobutyrate Transaminase; Alkynes; Aminocaproates; Animals; Baclofen; Body Temperature; Female; Flumazenil; gamma-Aminobutyric Acid; Male; Morphine; Rats; Rats, Inbred Strains | 1990 |
Evidence for GABA-BZ receptor modulation in short-term memory passive avoidance task paradigm in mice.
Topics: Animals; Avoidance Learning; Carbolines; Electroshock; Female; Flumazenil; gamma-Aminobutyric Acid; Male; Memory, Short-Term; Mice; Physostigmine; Receptors, GABA-A; Scopolamine | 1990 |
Benzodiazepine receptors modulate 5-hydroxytryptamine neurotransmission in the rat hippocampus: in vivo electrophysiological evidence.
Topics: Animals; Carbolines; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Hippocampus; Male; Piperazines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Serotonin; Synaptic Transmission | 1990 |
Flunitrazepam photoaffinity labeling of the GABA(A) receptor reduces inhibition of [3H]Ro15-4513 binding by GABA.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Brain; Chick Embryo; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Membranes; Photochemistry; Receptors, GABA-A | 1990 |
Chronic benzodiazepine antagonist treatment and its withdrawal upregulates components of GABA-benzodiazepine receptor ionophore complex in cerebral cortex of rat.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Convulsants; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, GABA-A; Reference Values; Up-Regulation | 1990 |
The activity of zolpidem and other hypnotics within the gamma-aminobutyric acid (GABAA) receptor supramolecular complex, as determined by 35S-t-butylbicyclophosphorothionate (35S-TBPS) binding to rat cerebral cortex membranes.
Topics: Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Hypnotics and Sedatives; In Vitro Techniques; Male; Pyridines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Zolpidem | 1990 |
Receptor binding characterization of the benzodiazepine radioligand 125I-Ro16-0154: potential probe for SPECT brain imaging.
Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Cerebral Cortex; Flumazenil; gamma-Aminobutyric Acid; Humans; Iodine Radioisotopes; Kidney; Kinetics; Macaca mulatta; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sodium Chloride; Tomography, Emission-Computed, Single-Photon | 1990 |
The effect of benzodiazepines and beta-carbolines on GABA-stimulated chloride influx by membrane vesicles from the rat cerebral cortex.
Topics: Animals; Benzodiazepines; Biological Transport; Carbolines; Cerebral Cortex; Chlorides; Drug Synergism; Flumazenil; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Channels; Rats; Receptors, GABA-A; Synaptic Vesicles | 1986 |
Stress-induced changes in t-[35S]butylbicyclophosphorothionate binding to gamma-aminobutyric acid-gated chloride channels are mimicked by in vitro occupation of benzodiazepine receptors.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cerebral Cortex; Chlorides; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Ion Channels; Kinetics; Male; Membranes; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stress, Physiological; Swimming | 1987 |
Allosteric modulation by benzodiazepine receptor ligands of the GABAA receptor channel expressed in Xenopus oocytes.
Topics: Animals; Benzodiazepines; Clorazepate Dipotassium; Electrophysiology; Flumazenil; gamma-Aminobutyric Acid; Ion Channels; Ligands; Oocytes; Osmolar Concentration; Receptors, GABA-A; Xenopus | 1988 |
Ethanol potentiation of GABAergic transmission in cultured spinal cord neurons involves gamma-aminobutyric acidA-gated chloride channels.
Topics: Animals; Azides; Benzodiazepines; Carbolines; Cells, Cultured; Chlorine; Ethanol; Female; Flumazenil; GABA Antagonists; gamma-Aminobutyric Acid; Ion Channels; Male; Mice; Mice, Inbred C57BL; Neurons; Radioisotopes; Spinal Cord | 1988 |
Inhibition of high-affinity synaptosomal uptake of gamma-aminobutyric acid by a bicyclo-heptane derivative.
Topics: Animals; Anticonvulsants; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Camphanes; Carbolines; Cerebral Cortex; Diazepam; Flumazenil; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Synaptic Membranes; Synaptosomes | 1989 |
Chronic exposure to Ro 15-1788: differential effect on flunitrazepam binding to cortex and hippocampus.
Topics: Animals; Cerebral Cortex; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Kinetics; Male; Membranes; Rats; Rats, Inbred Strains; Synaptosomes | 1989 |
Relationship of agonist efficacy to changes in GABA sensitivity and anticonvulsant tolerance following chronic benzodiazepine ligand exposure.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Bicuculline; Brain Chemistry; Diazepam; Drug Tolerance; Electrophysiology; Flumazenil; gamma-Aminobutyric Acid; Male; Raphe Nuclei; Rats; Rats, Inbred Strains; Seizures | 1989 |
Effect of GABAergic drugs on motor impairment from ethanol, barbital and lorazepam in rat lines selected for differential sensitivity to ethanol.
Topics: Animals; Barbital; Barbiturates; Dose-Response Relationship, Drug; Ethanol; Female; Flumazenil; GABA Antagonists; gamma-Aminobutyric Acid; Isoniazid; Lorazepam; Picrotoxin; Psychomotor Performance; Rats | 1989 |
Responses of substantia nigra pars reticulata neurons to benzodiazepine ligands after acute and prolonged diazepam exposure. I. Modulation of gamma-aminobutyric acid sensitivity.
Topics: Animals; Carbolines; Diazepam; Flumazenil; Flurazepam; gamma-Aminobutyric Acid; Ligands; Male; Neurons; Rats; Rats, Inbred Strains; Receptors, GABA-A; Substantia Nigra | 1989 |
Responses of substantia nigra pars reticulata neurons to benzodiazepine ligands after acute and prolonged diazepam exposure. II. Modulation of firing rate.
Topics: Animals; Carbolines; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Ligands; Male; Neurons; Rats; Rats, Inbred Strains; Receptors, GABA-A; Substantia Nigra | 1989 |
The tremorigen aflatrem is a positive allosteric modulator of the gamma-aminobutyric acidA receptor channel expressed in Xenopus oocytes.
Topics: Allosteric Regulation; Animals; Chloride Channels; Chlorides; Dose-Response Relationship, Drug; Flumazenil; gamma-Aminobutyric Acid; Indoles; Membrane Proteins; Mycotoxins; Oocytes; Pentobarbital; Picrotoxin; Receptors, GABA-A; Xenopus | 1989 |
Modification of evoked hippocampal dentate inhibition by diazepam and three antagonists in urethane-anesthetized rats.
Topics: Anesthesia; Animals; Diazepam; Evoked Potentials; Flumazenil; gamma-Aminobutyric Acid; Hippocampus; Isoquinolines; Male; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synapses; Urethane | 1989 |
Benzodiazepine receptor autoradiography in corpus striatum of rat after large frontal cortex lesions and chronic treatment with diazepam.
Topics: Animals; Autoradiography; Behavior, Animal; Cerebral Cortex; Corpus Striatum; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Male; Nucleus Accumbens; Rats; Receptors, GABA-A; Time Factors | 1989 |
Relative efficacies of 1,4-diazepines on GABA-stimulated chloride influx in rat brain vesicles.
Topics: Animals; Anti-Anxiety Agents; Azepines; Cell Membrane; Cerebral Cortex; Chlorides; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1989 |
Mechanisms of action of new antiepileptic drugs.
Topics: Acetamides; Acetates; Amines; Aminocaproates; Aminopyridines; Anti-Anxiety Agents; Anticonvulsants; Aspartic Acid; Benzodiazepines; Benzodiazepinones; Clobazam; Cyclohexanecarboxylic Acids; Dibenzocycloheptenes; Dizocilpine Maleate; Epilepsy; Felbamate; Flumazenil; GABA Antagonists; Gabapentin; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Imidazoles; Lamotrigine; Phenylcarbamates; Propylene Glycols; Receptors, GABA-A; Triazines; Vigabatrin | 1989 |
Effects of benzodiazepines and non-benzodiazepine compounds on the GABA-induced response in frog isolated sensory neurones.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Carbolines; Drug Synergism; Flumazenil; gamma-Aminobutyric Acid; In Vitro Techniques; Neurons, Afferent; Rana catesbeiana | 1989 |
Are the effects of benzodiazepines on discrimination and punishment dissociable?
Topics: Amygdala; Animals; Behavior, Animal; Benzodiazepines; Carbolines; Chlordiazepoxide; Discrimination, Psychological; Ethanolamines; Flumazenil; gamma-Aminobutyric Acid; Midazolam; Punishment; Pyrazoles; Rats; Receptors, GABA-A | 1987 |
Heterogeneity of gamma-aminobutyric acid/benzodiazepine/beta-carboline receptor complex in rat spinal cord.
Topics: Animals; Bicuculline; Binding, Competitive; Carbolines; Cerebellum; Diazepam; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Male; Muscimol; Rats; Receptors, GABA-A; Spinal Cord; Synaptic Membranes | 1988 |
Modulation of neurotransmitter receptor desensitization: chlordiazepoxide stimulates fading of the GABA response.
Topics: Animals; Chick Embryo; Chlordiazepoxide; Flumazenil; gamma-Aminobutyric Acid; Neurons; Receptors, GABA-A; Spinal Cord | 1988 |
Osmotic shock: a method to eliminate endogenous gamma-aminobutyric acid and account for the influence on benzodiazepine binding affinity in autoradiographic studies.
Topics: Animals; Autoradiography; Benzodiazepines; Bicuculline; Binding Sites; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Male; Osmotic Pressure; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1988 |
Sodium valproate decreases exploratory behaviour in mice: development of tolerance and cross-tolerance with chlordiazepoxide.
Topics: Animals; Chlordiazepoxide; Drug Tolerance; Exploratory Behavior; Flumazenil; gamma-Aminobutyric Acid; Male; Mice; Motor Activity; Receptors, GABA-A; Valproic Acid | 1988 |
Modulation of the electrically evoked release of 5-[3H]hydroxytryptamine from rat cerebral cortex: effects of alpidem, CL 218872, and diazepam.
Topics: Animals; Benzodiazepines; Carbolines; Cerebral Cortex; Diazepam; Electric Stimulation; Flumazenil; gamma-Aminobutyric Acid; Imidazoles; Male; Monoamine Oxidase Inhibitors; Pargyline; Pyrazoles; Pyridazines; Pyridines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Serotonin | 1988 |
Further characterization of benzodiazepine receptor differences in long-sleep and short-sleep mice.
Topics: Animals; Cerebellum; Cerebral Cortex; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Hot Temperature; In Vitro Techniques; Kinetics; Mice; Mice, Mutant Strains; Protein Conformation; Receptors, GABA-A; Sleep | 1988 |
The interaction of substituted benzamides with brain benzodiazepine binding sites in vitro.
Topics: Affinity Labels; Animals; Benzamides; Binding, Competitive; Brain Chemistry; Cattle; Cell Membrane; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Photochemistry; Receptors, GABA-A | 1988 |
Drugs which stimulate or facilitate central GABAergic transmission interact synergistically with delta-9-tetrahydrocannabinol to produce marked catalepsy in mice.
Topics: Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Catalepsy; Dronabinol; Drug Synergism; Flumazenil; Flupenthixol; Flurazepam; GABA Antagonists; gamma-Aminobutyric Acid; Male; Mice; Muscimol; Nipecotic Acids; Receptors, GABA-A; Strychnine; Taurine; Tiagabine | 1988 |
Discriminative stimulus properties of CGS 9896: interactions within the GABA/benzodiazepine receptor complex.
Topics: Animals; Carbolines; Chlordiazepoxide; Discrimination, Psychological; Dose-Response Relationship, Drug; Flumazenil; gamma-Aminobutyric Acid; Male; Pentobarbital; Pentylenetetrazole; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1988 |
Interoceptive stimuli produced by an anxiogenic drug are mimicked by benzodiazepine antagonists in rats pretreated with isoniazid.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepinones; Brain Chemistry; Convulsants; Discrimination, Psychological; Flumazenil; gamma-Aminobutyric Acid; Humans; Isoniazid; Male; Pentobarbital; Pentylenetetrazole; Pyrazoles; Rats | 1985 |
Modulation of neurotransmitter action: control of the gamma-aminobutyric acid response through the benzodiazepine receptor.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Carbolines; Chick Embryo; Electric Conductivity; Flumazenil; GABA Antagonists; gamma-Aminobutyric Acid; Neurotransmitter Agents; Picrotoxin; Pyridazines; Receptors, GABA-A | 1985 |
[Mechanism of the tranquilizing action of electron structural analogs of nicotinamide].
Topics: Animals; Benzodiazepinones; Bicuculline; Brain; Conflict, Psychological; Flumazenil; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Inosine; Male; Niacinamide; Radioligand Assay; Rats; Receptors, GABA-A; Serotonin; Synaptosomes; Tranquilizing Agents; Valproic Acid | 1986 |
[Benzodiazepines and benzodiazepine receptors].
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Bicuculline; Brain; Flumazenil; gamma-Aminobutyric Acid; Mice; Muscle Relaxants, Central; Pyrazoles; Rats; Receptors, GABA-A; Receptors, Neurotransmitter; Synaptic Transmission | 1986 |
[3H]Ro 15-1788 binding to benzodiazepine receptors in mouse brain in vivo: marked enhancement by GABA agonists and other CNS drugs.
Topics: Animals; Antipsychotic Agents; Barbiturates; Brain; Buspirone; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Injections, Intravenous; Male; Mice; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Vasodilator Agents | 1987 |
Modulation of GABA-stimulated chloride influx into membrane vesicles from rat cerebral cortex by benzodiazepines and nonbenzodiazepines.
Topics: Animals; Anti-Anxiety Agents; Cell Membrane; Cerebral Cortex; Chlorides; Clonazepam; Diazepam; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Rats; Rats, Inbred Strains | 1988 |
Effects of non-sedative anxiolytic drugs on responses to GABA and on diazepam-induced enhancement of these responses on mouse neurones in cell culture.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Buspirone; Carbolines; Cells, Cultured; Convulsants; Diazepam; Electrophysiology; Flumazenil; gamma-Aminobutyric Acid; Mice; Neurons; Pyrazoles; Quinolines; Spinal Cord | 1988 |
Acute barbiturate administration increases benzodiazepine receptor binding in vivo.
Topics: Animals; Anti-Anxiety Agents; Barbiturates; Brain Chemistry; Clonazepam; Flumazenil; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Male; Mice; Pentobarbital; Receptors, GABA-A | 1988 |
Effects of guanyl nucleotides on [3H]flunitrazepam binding to rat hippocampal synaptic membranes: equilibrium binding and dissociation kinetics.
Topics: Adenosine Triphosphate; Animals; Benzodiazepinones; Diazepam; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Guanine Nucleotides; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Hippocampus; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptic Membranes | 1985 |
Changes in the characteristics of low affinity GABA binding sites elicited by Ro15-1788.
Topics: Animals; Benzodiazepinones; Carbolines; Cerebral Cortex; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Handling, Psychological; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1985 |
Modulation of acetylcholine release from rat striatal slices by the GABA/benzodiazepine receptor complex.
Topics: Acetylcholine; Animals; Atropine; Baclofen; Benzodiazepinones; Clonazepam; Corpus Striatum; Electric Stimulation; Flumazenil; gamma-Aminobutyric Acid; Haloperidol; In Vitro Techniques; Isoxazoles; Muscimol; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1985 |
Involvement of a GABAergic mechanism in the anticonvulsant effect of pentobarbital against maximal electroshock-induced seizures in rats.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Bicuculline; Drug Interactions; Electroshock; Ethanol; Flumazenil; GABA Antagonists; gamma-Aminobutyric Acid; Male; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Sleep | 1985 |
Reduction of inhibition by a benzodiazepine antagonist, Ro15-1788, in the rat hippocampal slice.
Topics: Animals; Benzodiazepinones; Chlordiazepoxide; Diazepam; Electric Conductivity; Evoked Potentials; Flumazenil; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Neural Inhibition; Rats; Synaptic Transmission | 1985 |
Benzodiazepine binding characteristics of embryonic rat brain neurons grown in culture.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Brain; Carbolines; Cells, Cultured; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Flumazenil; gamma-Aminobutyric Acid; Neurons; Pyridazines; Rats; Receptors, GABA-A | 1985 |
Enhancement of GABA binding by the benzodiazepine partial agonist CGS9896.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Brain; Calcium Chloride; Diazepam; Flumazenil; gamma-Aminobutyric Acid; In Vitro Techniques; Magnesium; Pyrazoles; Pyridazines; Rats; Receptors, GABA-A | 1985 |
Differential sensitivity of "central" and "peripheral" type benzodiazepine receptors to phospholipase A2.
Topics: Animals; Benzodiazepinones; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Cerebral Cortex; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Kidney; Male; Myocardium; Pentobarbital; Phospholipases; Phospholipases A; Phospholipases A2; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1986 |
Regional difference in brain benzodiazepine receptor carbohydrates.
Topics: Acetylglucosaminidase; Animals; Asparagine; Benzodiazepinones; Brain Chemistry; Carbohydrates; Electrophoresis, Polyacrylamide Gel; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Male; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Molecular Weight; Muscimol; Neuraminidase; Pentobarbital; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sialic Acids; Tritium | 1986 |
Benzodiazepine receptor involvement in the control of receptive field size and responsiveness in primary somatosensory cortex.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Cats; Diazepam; Female; Flumazenil; Flurazepam; gamma-Aminobutyric Acid; Male; Midazolam; Neurons; Receptors, GABA-A; Sensory Thresholds; Somatosensory Cortex; Touch | 1986 |
Midazolam cue in rats: effects of Ro 15-1788 and picrotoxin.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Discrimination, Psychological; Dose-Response Relationship, Drug; Flumazenil; gamma-Aminobutyric Acid; Male; Midazolam; Nicotine; Pentobarbital; Picrotoxin; Rats; Receptors, GABA-A | 1986 |
Modulation of GABAA receptor activity by alphaxalone.
Topics: Acetylcholine; Anesthetics; Animals; Cattle; Cells, Cultured; Chromaffin System; Flumazenil; gamma-Aminobutyric Acid; Membrane Potentials; Pregnanediones; Receptors, GABA-A | 1987 |
The benzodiazepine agonist clonazepam potentiates the effects of gamma-aminobutyric acid on alpha-MSH release from neurointermediate lobes in vitro.
Topics: Animals; Clonazepam; Drug Synergism; Flumazenil; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Melanocyte-Stimulating Hormones; Perfusion; Pituitary Gland, Posterior; Rana ridibunda; Receptors, GABA-A | 1987 |
CGS 9896 and ZK 91296, but not CGS 8216 and RO 15-1788, are pure benzodiazepine receptor antagonists on mouse neurons in culture.
Topics: Animals; Brain; Carbolines; Cells, Cultured; Diazepam; Electrophysiology; Flumazenil; gamma-Aminobutyric Acid; Mice; Neurons; Pyrazoles; Receptors, GABA-A; Spinal Cord | 1987 |
Diazepam potentiates GABA-contraction in guinea-pig ileum.
Topics: Animals; Baclofen; Benzodiazepinones; Carbolines; Diazepam; Drug Synergism; Electric Stimulation; Flumazenil; gamma-Aminobutyric Acid; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth | 1986 |
Effect of RO 15-1788 on diazepam, GABA & pentobarbitone induced EEG changes in rabbits.
Topics: Animals; Cerebral Cortex; Diazepam; Electroencephalography; Electromyography; Female; Flumazenil; gamma-Aminobutyric Acid; Male; Pentobarbital; Rabbits | 1986 |
Modulation of gamma-aminobutyric acid-mediated inhibitory synaptic currents in dissociated cortical cell cultures.
Topics: Animals; Bicuculline; Carbolines; Cells, Cultured; Cerebral Cortex; Electric Conductivity; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Membrane Potentials; Neural Inhibition; Rats; Synapses | 1986 |
Modification of GABA turnover in the striatum and hippocampus of the rat after zopiclone.
Topics: Aminooxyacetic Acid; Animals; Azabicyclo Compounds; Benzodiazepinones; Corpus Striatum; Flumazenil; gamma-Aminobutyric Acid; Hippocampus; Hypnotics and Sedatives; Kinetics; Male; Piperazines; Rats; Rats, Inbred Strains | 1987 |
Persistent reversal of tolerance to anticonvulsant effects and GABAergic subsensitivity by a single exposure to benzodiazepine antagonist during chronic benzodiazepine administration.
Topics: Animals; Behavior, Animal; Benzodiazepines; Bicuculline; Drug Tolerance; Flumazenil; gamma-Aminobutyric Acid; Iontophoresis; Male; Neurons; Raphe Nuclei; Rats; Rats, Inbred Strains; Seizures | 1988 |
Stimulatory action of gamma-aminobutyric acid on catecholamine secretion from bovine adrenal chromaffin cells measured by a real-time monitoring system.
Topics: Adrenal Glands; Animals; Catecholamines; Cattle; Chromaffin System; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Magnesium; Nifedipine | 1988 |
Modulation of GABA-gated chloride ion flux in rat brain by acute and chronic benzodiazepine administration.
Topics: Animals; Benzodiazepines; Brain; Chlorides; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Flurazepam; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred Strains | 1988 |
Neurosteroid pregnenolone sulfate antagonizes electrophysiological responses to GABA in neurons.
Topics: Action Potentials; Animals; Animals, Newborn; Bicuculline; Cells, Cultured; Cerebral Cortex; Flumazenil; gamma-Aminobutyric Acid; Pentobarbital; Pregnenolone; Rats; Steroids | 1988 |
Benzodiazepine receptor ligand actions on GABA responses. Benzodiazepines, CL 218872, zopiclone.
Topics: Animals; Azabicyclo Compounds; Benzodiazepines; Benzodiazepinones; Cells, Cultured; Drug Interactions; Flumazenil; gamma-Aminobutyric Acid; Ligands; Mice; Neurons; Piperazines; Pyridazines; Receptors, Cell Surface; Receptors, GABA-A; Spinal Cord | 1984 |
CL 218,872 binding to benzodiazepine receptors in rat spinal cord: modulation by gamma-aminobutyric acid and evidence for receptor heterogeneity.
Topics: Animals; Benzodiazepinones; Cerebral Cortex; Flumazenil; gamma-Aminobutyric Acid; Male; Muscimol; Pyridazines; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Spinal Cord | 1984 |
Evaluation of the beta-carboline ZK 93 426 as a benzodiazepine receptor antagonist.
Topics: Animals; Anticonvulsants; Ataxia; Benzodiazepinones; Binding, Competitive; Carbolines; Diazepam; Discrimination, Psychological; Drinking; Exploratory Behavior; Flumazenil; gamma-Aminobutyric Acid; In Vitro Techniques; Indoles; Mice; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Neurotransmitter; Sleep | 1984 |
Multiple signals in GABAergic transmission: pharmacological consequences.
Topics: Amino Acid Sequence; Animals; Benzodiazepinones; Brain Chemistry; Diazepam Binding Inhibitor; Electric Stimulation; Flumazenil; gamma-Aminobutyric Acid; Isoniazid; Nerve Tissue Proteins; Rats; Synaptic Membranes; Synaptic Transmission | 1984 |
The effects of benzodiazepine agonists, inverse agonists and Ro 15-1788 on the responses of the superior cervical ganglion to GABA in vitro.
Topics: Animals; Barbiturates; Benzodiazepinones; Bicuculline; Carbolines; Chlordiazepoxide; Flumazenil; Flurazepam; gamma-Aminobutyric Acid; Ganglia, Sympathetic; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1984 |
Autoradiographic localisation of benzodiazepine receptors in the rat pituitary gland.
Topics: Animals; Autoradiography; Benzodiazepinones; Clonazepam; Flumazenil; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Pituitary Gland; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1984 |
Multiple effects of drugs acting on benzodiazepine receptors.
Topics: Animals; Benzodiazepinones; Calcium; Carbolines; Chlordiazepoxide; Drug Interactions; Flumazenil; gamma-Aminobutyric Acid; Male; Norepinephrine; Potassium; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1984 |
Benzodiazepine binding sites in human pineal gland.
Topics: Adolescent; Adult; Aged; Animals; Benzodiazepinones; Binding, Competitive; Cerebral Cortex; Child; Child, Preschool; Clonazepam; Diazepam; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Humans; In Vitro Techniques; Infant; Kinetics; Male; Middle Aged; Pineal Gland; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1984 |
An in vitro binding assay which differentiates benzodiazepine 'agonists' and 'antagonists'.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Binding, Competitive; Carbolines; Flumazenil; gamma-Aminobutyric Acid; Indoles; Male; Rats; Rats, Inbred Strains; Receptors, Drug; Receptors, GABA-A | 1982 |
Comparison of the kinetics of [3H]diazepam and [3H]flunitrazepam binding to cortical synaptosomal membranes.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Cerebral Cortex; Diazepam; Filtration; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Male; Pentobarbital; Rats; Rats, Inbred Strains; Sodium Chloride; Synaptic Membranes | 1982 |
Contrasting regulation by GABA of the displacement of benzodiazepine antagonist binding by benzodiazepine agonists and purines.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Binding, Competitive; Brain; Flumazenil; gamma-Aminobutyric Acid; Purines; Rats; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Synaptosomes | 1982 |
Enhancement of GABA binding by benzodiazepines and related anxiolytics.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Binding Sites; Brain; Flumazenil; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Synaptic Membranes | 1983 |
Differential effects of the benzodiazepine antagonist Ro 15-1788 on two types of myoclonus in baboon Papio papio.
Topics: 5-Hydroxytryptophan; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepinones; Flumazenil; gamma-Aminobutyric Acid; Light; Lorazepam; Myoclonus; Papio; Seizures | 1983 |
Are benzodiazepine recognition sites functional entities for the action of endogenous effector(s) or merely drug receptor(s)?
Topics: Animals; Benzodiazepinones; Brain; Flumazenil; gamma-Aminobutyric Acid; Humans; Isoniazid; Neurotransmitter Agents; Receptors, Cell Surface; Receptors, GABA-A; Seizures; Synaptic Membranes; Synaptic Transmission | 1983 |
Antagonists of benzodiazepines: functional aspects.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Carbolines; Chlorides; Flumazenil; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Ion Channels; Narcotic Antagonists; Parasympathomimetics; Pyrazoles; Receptors, Cell Surface; Receptors, GABA-A; Substance-Related Disorders; Xanthines | 1983 |
Benzodiazepine Ro 15-1788: electrophysiological evidence for partial agonist activity.
Topics: Animals; Benzodiazepinones; Culture Techniques; Diazepam; Dose-Response Relationship, Drug; Flumazenil; gamma-Aminobutyric Acid; Ganglia, Spinal; Glutamates; Glutamic Acid; Membrane Potentials; Mice; Neurons; Receptors, Cell Surface; Receptors, GABA-A; Spinal Cord; Synaptic Transmission | 1983 |
Central benzodiazepine receptors in the spinal cord and other regions of the CNS of the cat.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Binding, Competitive; Cats; Central Nervous System; Cerebellum; Cerebral Cortex; Female; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Male; Receptors, GABA-A; Spinal Cord | 1984 |
Reversal of the antiaversive and anticonvulsant actions of diazepam, but not of progabide, by a selective antagonist of benzodiazepine receptors.
Topics: Animals; Anxiety; Benzodiazepinones; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Humans; Rats; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Receptors, Neurotransmitter; Seizures | 1981 |
Unusual interactions of benzodiazepine receptor antagonists.
Topics: Animals; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Biological Assay; Carbolines; Flumazenil; gamma-Aminobutyric Acid; Ganglia, Sympathetic; Indoles; Rats; Receptors, Drug; Receptors, GABA-A; Receptors, Neurotransmitter; Seizures | 1982 |
Specific proconvulsant action of an imidazobenzodiazepine (RO 15-1788) on isoniazid convulsions.
Topics: Animals; Benzodiazepinones; Brain; Convulsants; Drug Synergism; Flumazenil; gamma-Aminobutyric Acid; Isoniazid; Male; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Drug; Receptors, GABA-A; Receptors, Neurotransmitter; Seizures | 1982 |
Benzodiazepine antagonists abolish electrophysiological effects of sodium valproate in the rat.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Diazepam; Evoked Potentials, Visual; Female; Flumazenil; gamma-Aminobutyric Acid; Immobilization; Kinetics; Male; Rats; Receptors, Drug; Receptors, GABA-A; Valproic Acid | 1982 |
The action of benzodiazepine antagonist Ro 15-1788 on the effects of GABA-ergic drugs.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aggression; Animals; Baclofen; Benzodiazepines; Benzodiazepinones; Brain Chemistry; Flumazenil; gamma-Aminobutyric Acid; Humans; Male; Motor Activity; Muscimol; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Ethanol and the gamma-aminobutyric acid-benzodiazepine receptor complex.
Topics: Animals; Benzodiazepinones; Brain; Carbolines; Ethanol; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Male; Membranes; Muscimol; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Temperature | 1984 |
Involvement of GABA in the facilitation of punishment suppressed behavior induced by beta-carbolines in rat.
Topics: Animals; Anxiety; Benzodiazepinones; Carbolines; Conditioning, Operant; Diazepam; Drug Interactions; Flumazenil; gamma-Aminobutyric Acid; Humans; Indoles; Models, Psychological; Punishment; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Interactions of different ligand classes with the benzodiazepine receptor.
Topics: Affinity Labels; Animals; Benzodiazepinones; Binding, Competitive; Carbolines; Flumazenil; gamma-Aminobutyric Acid; Humans; Ligands; Membranes; Rats; Receptors, Cell Surface; Receptors, GABA-A; Sodium Chloride | 1983 |
Ro 15-1788 is a potent antagonist of benzodiazepines in the olfactory cortex slice.
Topics: Anesthetics; Animals; Benzodiazepines; Benzodiazepinones; Cerebral Cortex; Dose-Response Relationship, Drug; Flumazenil; gamma-Aminobutyric Acid; Guinea Pigs; In Vitro Techniques; Membrane Potentials; Muscimol | 1983 |
Reversal of the muscle relaxant effect of diazepam but not of progabide by a specific benzodiazepine antagonist: Ro 15-1788.
Topics: Animals; Benzodiazepinones; Diazepam; Female; Flumazenil; GABA Antagonists; gamma-Aminobutyric Acid; Male; Muscle Contraction; Muscle Relaxants, Central; Rats; Rats, Inbred Strains; Time Factors | 1983 |
Chlordiazepoxide reduces in vivo serotonin release in the basal ganglia of encéphale isolé but not anesthetized cats: evidence for a dorsal raphe site of action.
Topics: Anesthesia; Animals; Basal Ganglia; Benzodiazepinones; Brain Stem; Cats; Chlordiazepoxide; Decerebrate State; Female; Flumazenil; gamma-Aminobutyric Acid; Halothane; Hippocampus; Injections, Intraperitoneal; Male; Raphe Nuclei; Serotonin | 1983 |
Actions of midazolam in the spinal cord of the cat.
Topics: Afferent Pathways; Animals; Benzodiazepines; Benzodiazepinones; Cats; Flumazenil; gamma-Aminobutyric Acid; Interneurons; Midazolam; Norepinephrine; Reflex; Spinal Cord | 1983 |
Electrophysiological studies on benzodiazepine antagonists.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Carbolines; Cells, Cultured; Electric Stimulation; Electrophysiology; Flumazenil; Flurazepam; gamma-Aminobutyric Acid; Hippocampus; Hypothalamus; Indoles; Neural Inhibition; Neurons; Rats; Rats, Inbred Strains | 1984 |
Antiepileptic effects of amphetamine may require GABA (benzodiazepine) activity.
Topics: Amphetamine; Animals; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Female; Flumazenil; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred Strains; Seizures | 1984 |
Anticonvulsant actions of the putative gamma-aminobutyric acid (GABA)-mimetic, ethylenediamine.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Ethylenediamines; Flumazenil; gamma-Aminobutyric Acid; Male; Mice | 1982 |
Central-type benzodiazepine receptors mediate the antidopaminergic effect of clonazepam and melatonin in 6-hydroxydopamine lesioned rats: involvement of a GABAergic mechanism.
Topics: Animals; Apomorphine; Behavior, Animal; Bicuculline; Clonazepam; Corpus Striatum; Dopamine Agonists; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Isoquinolines; Male; Melatonin; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1995 |
Astroglia-released factor shows similar effects as benzodiazepine inverse agonists.
Topics: Animals; Animals, Newborn; Appetite Depressants; Astrocytes; Benzodiazepines; Biological Factors; Brain; Carbolines; Cells, Cultured; Cerebellum; Cerebral Cortex; Culture Media, Conditioned; Dose-Response Relationship, Drug; Embryo, Mammalian; Flumazenil; gamma-Aminobutyric Acid; Ganglia, Spinal; Glutamic Acid; Hippocampus; Membrane Potentials; Molecular Weight; Neurons; PC12 Cells; Rats; Receptors, GABA-A | 1994 |
Potentiation of gamma-aminobutyric acid-induced chloride currents by various benzodiazepine site agonists with the alpha 1 gamma 2, beta 2 gamma 2 and alpha 1 beta 2 gamma 2 subtypes of cloned gamma-aminobutyric acid type A receptors.
Topics: Anti-Anxiety Agents; Azabicyclo Compounds; Benzodiazepines; Binding Sites; Cells, Cultured; Chloride Channels; Cloning, Molecular; Drug Synergism; Flumazenil; gamma-Aminobutyric Acid; Humans; Hypnotics and Sedatives; Imidazoles; Kidney; Kinetics; Membrane Potentials; Piperazines; Pyridazines; Pyridines; Receptors, GABA-A; Triazolam | 1993 |
Benzodiazepine treatment causes uncoupling of recombinant GABAA receptors expressed in stably transfected cells.
Topics: Allosteric Site; Animals; Benzodiazepines; Cattle; Cell Line; Clonazepam; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Mice; Receptors, GABA; Recombinant Proteins; Transfection | 1994 |
Substituted pyrazinones, a new class of allosteric modulators for gamma-aminobutyric acidA receptors.
Topics: Allosteric Regulation; Benzyl Compounds; Cell Line; Chlorides; Dose-Response Relationship, Drug; Flumazenil; Furans; gamma-Aminobutyric Acid; Humans; Pyrazines; Receptors, GABA-A | 1993 |
Pharmacological relevance of peripheral type benzodiazepine receptors on motor nerve and skeletal muscle.
Topics: Animals; Benzodiazepinones; Diaphragm; Electric Stimulation; Electrophysiology; Female; Flumazenil; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Microelectrodes; Motor Endplate; Motor Neurons; Muscle Contraction; Muscles; Neostigmine; Phrenic Nerve | 1994 |
Melatonin as an anxiolytic in rats: time dependence and interaction with the central GABAergic system.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Behavior, Animal; Brain; Circadian Rhythm; Diazepam; Dose-Response Relationship, Drug; Drug Administration Schedule; Flumazenil; gamma-Aminobutyric Acid; Male; Melatonin; Rats; Rats, Wistar | 1993 |
Effect of penicillin on GABA-gated chloride ion influx.
Topics: Animals; Brain; Chloride Channels; Dose-Response Relationship, Drug; Flumazenil; gamma-Aminobutyric Acid; Ion Channel Gating; Kinetics; Mice; Mice, Inbred Strains; Penicillin G | 1994 |
beta-Lumicolchicine interacts with the benzodiazepine binding site to potentiate GABAA receptor-mediated currents.
Topics: Animals; Benzodiazepines; Binding Sites; Binding, Competitive; Cerebral Cortex; Chlorides; DNA, Complementary; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Kinetics; Lumicolchicines; Mice; Mice, Inbred ICR; Oocytes; Receptors, GABA-A; Xenopus laevis | 1994 |
Chronic benzodiazepine agonist treatment produces functional uncoupling of the gamma-aminobutyric acid-benzodiazepine receptor ionophore complex in cortical neurons.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Cerebral Cortex; Chloride Channels; Female; Flumazenil; Flurazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Channel Gating; Macromolecular Substances; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Receptors, GABA; Receptors, GABA-A | 1994 |
Zinc selectively inhibits flux through benzodiazepine-insensitive gamma-aminobutyric acid chloride channels in cortical and cerebellar microsacs.
Topics: Animals; Benzodiazepines; Cerebellum; Cerebral Cortex; Chloride Channels; Chlorides; Chlorine; Drug Synergism; Flumazenil; Flunitrazepam; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Kinetics; Radioisotopes; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Stimulation, Chemical; Tritium; Zinc | 1993 |
Tolerance to the behavioral effects of chlordiazepoxide: pharmacological and biochemical selectivity.
Topics: Amphetamine; Animals; Behavior, Animal; Caffeine; Carbolines; Chlordiazepoxide; Chlorides; Chlorine; Dose-Response Relationship, Drug; Drug Tolerance; Flumazenil; gamma-Aminobutyric Acid; Male; Midazolam; Morphine; Pentobarbital; Radioisotopes; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sensitivity and Specificity; Stimulation, Chemical | 1993 |
Effects of midazolam and flumazenil on ventilation during sustained hypoxia in humans.
Topics: Adult; Analysis of Variance; Brain Stem; Flumazenil; gamma-Aminobutyric Acid; Humans; Hypoxia; Infusions, Intravenous; Male; Midazolam; Pulmonary Gas Exchange; Respiration; Time Factors | 1993 |
Ammonia potentiates GABAA response in dissociated rat cortical neurons.
Topics: Ammonia; Animals; Barbiturates; Cerebral Cortex; Chloride Channels; Drug Synergism; Flumazenil; gamma-Aminobutyric Acid; In Vitro Techniques; Membrane Proteins; Neurons; Rats; Rats, Wistar; Receptors, GABA-A | 1993 |
Intraseptal injection of GABA and benzodiazepine receptor ligands alters high-affinity choline transport in the hippocampus.
Topics: Acetylcholinesterase; Animals; Baclofen; Brain; Carbolines; Chlordiazepoxide; Choline; Convulsants; Flumazenil; gamma-Aminobutyric Acid; Hippocampus; Injections; Male; Muscimol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Synaptosomes | 1993 |
Imidazenil: a new partial positive allosteric modulator of gamma-aminobutyric acid (GABA) action at GABAA receptors.
Topics: Allosteric Regulation; Animals; Benzodiazepines; Benzodiazepinones; Chloride Channels; Conflict, Psychological; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Imidazoles; Male; Membrane Proteins; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reflex; Seizures | 1993 |
Transduction of a discriminative stimulus through a diazepam-insensitive gamma-aminobutyric acidA receptor.
Topics: Animals; Columbidae; Diazepam; Discrimination Learning; Flumazenil; gamma-Aminobutyric Acid; Male; Receptors, GABA-A | 1993 |
Divergent alterations in gamma-aminobutyric acid/benzodiazepine responses of male and ovariectomized rats after chronic benzodiazepine agonist exposure: electrophysiological analysis of substantia nigra pars reticulata neurons.
Topics: Animals; Benzodiazepines; Female; Flumazenil; gamma-Aminobutyric Acid; Male; Ovariectomy; Rats; Receptors, GABA-A; Sex Factors; Substantia Nigra | 1993 |
[123I]iomazenil SPECT imaging demonstrates significant benzodiazepine receptor reserve in human and nonhuman primate brain.
Topics: Adult; Animals; Binding, Competitive; Brain; Dialysis; Female; Flumazenil; gamma-Aminobutyric Acid; Half-Life; Humans; Hypnotics and Sedatives; Iodine Radioisotopes; Lorazepam; Male; Nipecotic Acids; Ovariectomy; Papio; Receptors, GABA-A; Tiagabine; Tomography, Emission-Computed, Single-Photon | 1993 |
Potentiation of gamma-aminobutyric acid type A receptor-mediated synaptic currents by pentobarbital and diazepam in immature hippocampal CA1 neurons.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Diazepam; Drug Synergism; Flumazenil; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; Neurons; Pentobarbital; Rats; Rats, Wistar; Receptors, GABA-A; Synapses | 1993 |
Chronic flumazenil alters GABA(A) receptor subunit mRNA expression, translation product assembly and channel function in neuronal cultures.
Topics: Animals; Cells, Cultured; Cerebellum; Chloride Channels; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger | 1996 |
Behavioral and biochemical characterization of benzodiazepine receptor partial agonists in pigeons.
Topics: Animals; Anti-Anxiety Agents; Columbidae; Discrimination Learning; Flumazenil; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Male; Midazolam; Punishment | 1996 |
Proconflict effect of carbon dioxide inhalation in rats.
Topics: Administration, Inhalation; Alprazolam; Animals; Carbon Dioxide; Conflict, Psychological; Flumazenil; gamma-Aminobutyric Acid; Male; Rats; Rats, Sprague-Dawley | 1995 |
Studies on annelated 1,4-benzothiazines and 1,5-benzothiazepines. X--Synthesis and inhibition of benzodiazepine receptor binding of new 1,4-thiazine and 1,5-thiazepine polycondensed heterocycles with steroidal structure.
Topics: Animals; Binding, Competitive; Cattle; Cerebral Cortex; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Quinolines; Receptors, GABA-A; Thiazines; Triazoles | 1996 |
Effects of clobazam and its active metabolite on GABA-activated currents in rat cerebral neurons in culture.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Cells, Cultured; Cerebral Cortex; Chloride Channels; Clobazam; Dose-Response Relationship, Drug; Epilepsy; Flumazenil; gamma-Aminobutyric Acid; Humans; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, GABA; Synaptic Transmission | 1996 |
Benzodiazepine receptors in focal epilepsy with cortical dysgenesis: an 11C-flumazenil PET study.
Topics: Adult; Aged; Carbon Radioisotopes; Cerebral Cortex; Epilepsies, Partial; Female; Flumazenil; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Receptors, GABA; Receptors, GABA-A; Tomography, Emission-Computed | 1996 |
Vigabatrin modulates benzodiazepine receptor activity in vivo: a positron emission tomography study in baboon.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flumazenil; gamma-Aminobutyric Acid; Linear Models; Male; Papio; Radioligand Assay; Receptors, GABA-A; Tomography, Emission-Computed; Vigabatrin | 1996 |
Effects of benzodiazepine receptor ligands on isolated rat superior cervical ganglia neurons.
Topics: Age Factors; Animals; Animals, Newborn; Anti-Anxiety Agents; Diazepam; Electrophysiology; Flumazenil; gamma-Aminobutyric Acid; Ligands; Neurons; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Superior Cervical Ganglion | 1996 |
Diazepam physical dependence and withdrawal in rats is associated with alteration in GABAA receptor function.
Topics: Animals; Benzodiazepines; Cerebral Cortex; Chloride Channels; Chlorides; Diazepam; Flumazenil; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred F344; Receptors, GABA-A; Substance Withdrawal Syndrome; Substance-Related Disorders | 1996 |
Correlation between reduced in vivo benzodiazepine receptor binding and severity of psychotic symptoms in schizophrenia.
Topics: Adolescent; Adult; Cerebral Cortex; Female; Flumazenil; Frontal Lobe; gamma-Aminobutyric Acid; Humans; Male; Psychiatric Status Rating Scales; Receptors, GABA-A; Schizophrenia; Schizophrenic Psychology; Severity of Illness Index; Temporal Lobe; Tomography, Emission-Computed, Single-Photon | 1997 |
Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit.
Topics: Amino Acid Sequence; Anesthetics, Intravenous; Animals; Bicuculline; Brain; Cell Line; Consensus Sequence; DNA, Complementary; Flumazenil; Flunitrazepam; GABA Agents; gamma-Aminobutyric Acid; Humans; Molecular Sequence Data; Muscimol; Pentobarbital; Picrotoxin; Pregnanolone; Propofol; Rats; Receptors, GABA-A; Recombinant Proteins; RNA, Messenger; Transfection | 1997 |
In vivo modulation of benzodiazepine receptor function after inhibition of endogenous gamma-aminobutyyric acid synthesis.
Topics: Allylglycine; Animals; Binding, Competitive; Brain; Convulsants; Diazepam; Electroencephalography; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Ligands; Male; Papio; Pentylenetetrazole; Tomography, Emission-Computed | 1997 |
Central corticotropin-releasing factor and benzodiazepine receptor systems are involved in the social isolation stress-induced decrease in ethanol sleep in mice.
Topics: Animals; Brain; Central Nervous System Depressants; Chlorides; Corticotropin-Releasing Hormone; Ethanol; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hormone Antagonists; Housing, Animal; Male; Mice; Receptors, GABA-A; Sleep; Social Isolation; Stress, Psychological; Synaptosomes | 1997 |
Lactone modulation of the gamma-aminobutyric acid A receptor: evidence for a positive modulatory site.
Topics: 4-Butyrolactone; Animals; Chlordiazepoxide; Female; Flumazenil; gamma-Aminobutyric Acid; Lactones; Phenobarbital; Picrotoxin; Receptors, GABA-A; Xenopus laevis | 1997 |
Non-GABAergic effects of midazolam, diazepam and flumazenil on voltage-dependent ion currents in NG108-15 cells.
Topics: Animals; Calcium Channels; Diazepam; Dose-Response Relationship, Drug; Flumazenil; gamma-Aminobutyric Acid; Glioma; Hybrid Cells; Ion Channels; Membrane Potentials; Midazolam; Neuroblastoma; Patch-Clamp Techniques; Potassium Channels; Receptors, GABA-A; Sodium Channels | 1997 |
Benzodiazepine receptor binding and schizophrenia.
Topics: Flumazenil; Frontal Lobe; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Imaging; Prefrontal Cortex; Receptors, GABA-A; Schizophrenia; Schizophrenic Psychology; Severity of Illness Index; Tomography, Emission-Computed, Single-Photon | 1997 |
Decreased brain GABA(A)-benzodiazepine receptor binding in panic disorder: preliminary results from a quantitative PET study.
Topics: Adult; Aged; Brain; Carbon Radioisotopes; Cerebral Cortex; Female; Flumazenil; Functional Laterality; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Panic Disorder; Personality Inventory; Receptors, GABA-A; Sex Factors; Tissue Distribution; Tomography, Emission-Computed | 1998 |
Differential interaction between 5-HT3 receptors and GABAergic neurons inhibiting acetylcholine release in rat entorhinal cortex slices.
Topics: Acetylcholine; Animals; Barium; Bicuculline; Chloride Channels; Culture Techniques; Entorhinal Cortex; Flumazenil; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Male; Neurons; Ondansetron; Perfusion; Potassium Channel Blockers; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin Antagonists; Tetraethylammonium; Tropanes | 1998 |
[Characteristics of human lymphocyte benzodiazepine receptors].
Topics: Adult; Baclofen; Benzodiazepinones; Binding, Competitive; Diazepam; Flumazenil; GABA Agonists; gamma-Aminobutyric Acid; Humans; In Vitro Techniques; Ligands; Lymphocytes; Male; Receptors, GABA-A | 1998 |
Benzodiazepine modulation of recombinant alpha1beta3gamma2 GABA(A) receptor function efficacy determination using the Cytosensor microphysiometer.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Biosensing Techniques; Cell Count; Cells, Cultured; Dose-Response Relationship, Drug; Eukaryotic Cells; Flumazenil; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Humans; Pyridines; Receptors, GABA-A; Recombinant Proteins; Time Factors; Zolpidem | 1998 |
Stimulation of benzodiazepine receptors in the dorsal hippocampus and median raphé reveals differential GABAergic control in two animal tests of anxiety.
Topics: Animals; Anxiety; Behavior, Animal; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; Male; Maze Learning; Microinjections; Midazolam; Raphe Nuclei; Rats; Rats, Inbred Strains; Receptors, GABA-A; Social Behavior | 1998 |
Temperature dependence and GABA modulation of beta-carboline binding to rat cerebellum benzodiazepine receptors.
Topics: Animals; Carbolines; Cerebellum; Flumazenil; gamma-Aminobutyric Acid; Male; Rats; Rats, Wistar; Receptors, GABA-A; Temperature; Thermodynamics; Tritium | 1999 |
Acute pentylenetetrazol injection reduces rat GABAA receptor mRNA levels and GABA stimulation of benzodiazepine binding with No effect on benzodiazepine binding site density.
Topics: Animals; Autoradiography; Brain; Down-Regulation; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Male; Muscimol; Pentylenetetrazole; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Time Factors; Transcription, Genetic; Tritium | 1999 |
Diazepam reduces action potential duration in guinea-pig papillary muscle by a cAMP-dependent mechanism.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Action Potentials; Animals; Carbachol; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Diazepam; Enzyme Inhibitors; Flumazenil; gamma-Aminobutyric Acid; Guinea Pigs; In Vitro Techniques; Papillary Muscles; Thionucleotides | 1999 |
Dual action of the benzodiazepine receptor inverse agonist RU34347 on responses to exogenously applied GABA in the rat cerebellar slice.
Topics: Animals; Cerebellum; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Imidazoles; Male; Purkinje Cells; Pyrimidines; Rats; Rats, Wistar; Synaptic Transmission | 1999 |
Role of the conserved lysine residue in the middle of the predicted extracellular loop between M2 and M3 in the GABA(A) receptor.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Bicuculline; Binding, Competitive; Cell Line; Conserved Sequence; Female; Flumazenil; gamma-Aminobutyric Acid; Humans; Kinetics; Lysine; Muscimol; Mutagenesis, Site-Directed; Oocytes; Protein Structure, Secondary; Radioligand Assay; Rats; Receptors, GABA-A; Recombinant Proteins; Sequence Alignment; Transfection; Xenopus laevis | 1999 |
Topiramate modulates GABA-evoked currents in murine cortical neurons by a nonbenzodiazepine mechanism.
Topics: Action Potentials; Animals; Anticonvulsants; Cells, Cultured; Cerebral Cortex; Clonazepam; Evoked Potentials; Flumazenil; Fructose; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Mice; Neurons; Patch-Clamp Techniques; Pentylenetetrazole; Receptors, GABA; Seizures; Topiramate | 2000 |
Electrophysiological evidence for the coexistence of alpha1 and alpha6 subunits in a single functional GABA(A) receptor.
Topics: Allosteric Site; Animals; Benzodiazepines; Cells, Cultured; Cerebellum; Diuretics; DNA, Complementary; Dose-Response Relationship, Drug; Electrophysiology; Flumazenil; Furosemide; GABA Modulators; gamma-Aminobutyric Acid; Gene Expression; Ligands; Membrane Potentials; Neurons; Oocytes; Receptors, GABA-A; Recombinant Proteins; Xenopus laevis | 2000 |
Modulation of GABAergic synaptic transmission by the non-benzodiazepine anxiolytic etifoxine.
Topics: Animals; Behavior, Animal; Bicuculline; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Dose-Response Relationship, Drug; Drinking Behavior; Flumazenil; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hypothalamus; Isoquinolines; Male; Membrane Potentials; Membranes; Neurons; Oxazines; Patch-Clamp Techniques; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, GABA-A; Sulfur Radioisotopes; Synaptic Transmission; Tetrodotoxin; Tranquilizing Agents | 2000 |
Could flumazenil reverse neurological deficits in acute cerebral ischemia?
Topics: Acute Disease; Brain Ischemia; Carotid Artery Thrombosis; Carotid Artery, Internal; Cerebral Angiography; Drug Therapy, Combination; Dysarthria; Ethics, Medical; Flumazenil; GABA Agonists; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Glycerol; Hemodynamics; Heparin; Humans; Male; Middle Aged; Paresis; Recurrence; Thrombolytic Therapy | 1999 |
Benzodiazepines act on GABAA receptors via two distinct and separable mechanisms.
Topics: Animals; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug; Flumazenil; gamma-Aminobutyric Acid; Membrane Potentials; Mutation; Oocytes; Receptors, GABA-A; RNA, Messenger; Xenopus laevis; Zinc | 2000 |
Evidence that long-lasting potentiation of amygdala efferents in the right hemisphere underlies pharmacological stressor (FG-7142) induced lasting increases in anxiety-like behaviour: role of GABA tone in initiation of brain and behavioural changes.
Topics: Aggression; Amygdala; Animals; Anticonvulsants; Anxiety; Behavior, Animal; Brain Chemistry; Carbolines; Cats; Efferent Pathways; Flumazenil; Functional Laterality; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Hypothalamus, Middle; Male; Predatory Behavior; Rats; Receptors, GABA-A; Stress, Psychological; Vigabatrin; Vocalization, Animal | 2000 |
[3H]Ro 15-1788 binding sites to brain membrane of the saltwater Mugil cephalus.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Carbolines; Cell Membrane; Chlorides; Diazepam; Female; Fishes; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Imidazoles; Ionophores; Male; Pyridines; Receptors, GABA-A; Synaptosomes; Tritium; Zolpidem | 2001 |
Mice performance on the staircase test following acute ethanol administration.
Topics: Animals; Azides; Benzodiazepines; Central Nervous System Depressants; Diazepam; Dose-Response Relationship, Drug; Ethanol; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred ICR; Psychomotor Performance | 2001 |
Behavioral effects of agents active at the gamma-aminobutyric acid receptor complex in the staircase paradigm.
Topics: Acetates; Adjuvants, Immunologic; Amines; Animals; Anti-Anxiety Agents; Anxiety; Azabicyclo Compounds; Behavior, Animal; Brain; Clonazepam; Cyclohexanecarboxylic Acids; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dose-Response Relationship, Drug; Exploratory Behavior; Flumazenil; GABA Modulators; Gabapentin; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Male; Mice; Mice, Inbred ICR; Motor Activity; Neurons; Piperazines; Receptors, GABA-A | 2001 |
Reversal of reserpine-induced vacuous chewing movements in rats by melatonin: involvement of peripheral benzodiazepine receptors.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Interactions; Dyskinesia, Drug-Induced; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Isoquinolines; Male; Mastication; Melatonin; Neostriatum; Prazosin; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, GABA-A; Receptors, Melatonin; Reserpine; Tryptamines | 2001 |
SPECT and neuropsychological performance in severe depression treated with ECT.
Topics: Adult; Brain; Cerebral Cortex; Depressive Disorder, Major; Dominance, Cerebral; Electroconvulsive Therapy; Female; Flumazenil; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Neuropsychological Tests; Radioligand Assay; Receptors, GABA-A; Regional Blood Flow; Synaptic Transmission; Temporal Lobe; Tomography, Emission-Computed, Single-Photon; Treatment Outcome | 2001 |
Synergistic interaction of diazepam with 3',5'-cyclic adenosine monophosphate-elevating agents on rat aortic rings.
Topics: Animals; Aorta, Thoracic; Colforsin; Cyclic AMP; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Female; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; In Vitro Techniques; Isoproterenol; Isoquinolines; Male; Milrinone; Muscle Relaxants, Central; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phenylephrine; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2001 |
Role of the histidine residue at position 105 in the human alpha 5 containing GABA(A) receptor on the affinity and efficacy of benzodiazepine site ligands.
Topics: Anticonvulsants; Arginine; Azides; Benzodiazepines; Benzodiazepinones; Binding Sites; Binding, Competitive; Cell Line; Cells, Cultured; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Histidine; Humans; Ligands; Mutation; Protein Subunits; Receptors, GABA-A | 2002 |
Modulation of radioligand binding to the GABA(A)-benzodiazepine receptor complex by a new component from Cyperus rotundus.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Cyperaceae; Flumazenil; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Plant Extracts; Plant Roots; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sesquiterpenes | 2002 |
Mechanism of alpha-subunit selectivity of benzodiazepine pharmacology at gamma-aminobutyric acid type A receptors.
Topics: Animals; Anti-Anxiety Agents; Binding, Competitive; Cell Line; Diazepam; Dose-Response Relationship, Drug; Female; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Membrane Potentials; Mutation; Oocytes; Protein Subunits; Pyridazines; Pyridines; Radioligand Assay; Receptors, GABA-A; Tritium; Xenopus laevis; Zolpidem | 2002 |
The influences of extremely low frequency magnetic fields on clonidine-induced sleep in 2-day-old chicks.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Animals, Newborn; Bicuculline; Brain Chemistry; Chickens; Chromatography, High Pressure Liquid; Clonidine; Dose-Response Relationship, Drug; Electrochemistry; Electromagnetic Fields; Flumazenil; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Norepinephrine; Sleep; Tyrosine | 2001 |
3beta -hydroxypregnane steroids are pregnenolone sulfate-like GABA(A) receptor antagonists.
Topics: Amino Acid Substitution; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Flumazenil; GABA Antagonists; GABA Modulators; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hydroxysteroids; Lorazepam; Oocytes; Patch-Clamp Techniques; Pregnanes; Pregnenolone; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Structure-Activity Relationship; Synapses; Xenopus laevis | 2002 |
Effects of striatal injections of GABA(A) receptor agonists and antagonists in a genetic animal model of paroxysmal dystonia.
Topics: Animals; Bicuculline; Binding Sites; Corpus Striatum; Cricetinae; Dystonia; Female; Flumazenil; Flurazepam; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Male; Mesocricetus; Microinjections; Muscimol; Pentylenetetrazole; Phenobarbital | 2002 |
Gaba-benzodiazepine receptor complex in brain oxidative metabolism regulation.
Topics: Animals; Diazepam; Flumazenil; Frontal Lobe; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Male; Oxygen Consumption; Picrotoxin; Rats; Rats, Wistar | 2002 |
The heterogeneity of central benzodiazepine receptor subtypes in the human hippocampal formation, frontal cortex and cerebellum using [3H]flumazenil and zolpidem.
Topics: Cerebellum; Clonazepam; Flumazenil; Frontal Lobe; GABA Agents; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; Humans; Male; Middle Aged; Neurons; Protein Binding; Pyridines; Radioligand Assay; Receptors, GABA-A; Synaptic Transmission; Tritium; Zolpidem | 2002 |
Effects of cholecystokinin tetrapeptide (CCK(4)) and of anxiolytic drugs on GABA outflow from the cerebral cortex of freely moving rats.
Topics: Adamantane; Animals; Anti-Anxiety Agents; Buspirone; Cerebral Cortex; Diazepam; Epidural Space; Female; Flumazenil; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Male; Motor Activity; Muscle Relaxants, Central; Nerve Tissue Proteins; Phenylurea Compounds; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tetragastrin | 2003 |
Flumazenil and dialysis for gabapentin-induced coma.
Topics: Acetates; Aged; Aged, 80 and over; Amines; Analgesics; Antidotes; Coma; Cyclohexanecarboxylic Acids; Flumazenil; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Phantom Limb; Renal Dialysis | 2003 |
The influence of midazolam and flumazenil on rat brain slices oxygen consumption.
Topics: Animals; Anti-Anxiety Agents; Brain Chemistry; Cerebral Cortex; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Midazolam; Neurotransmitter Agents; Oxygen Consumption; Rats; Receptors, GABA-A | 2003 |
Gamma-aminobutyric acid neuropharmacological investigations on narcosis produced by nitrogen, argon, or nitrous oxide.
Topics: Anesthesia, Inhalation; Animals; Argon; Baclofen; Flumazenil; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Injections, Intraventricular; Male; Motor Activity; Nitrogen; Nitrous Oxide; Pyridazines; Rats; Rats, Sprague-Dawley | 2003 |
Cerebral benzodiazepine receptors in depressed patients measured with [123I]iomazenil SPECT.
Topics: Adult; Binding Sites; Brain; Depressive Disorder, Major; Female; Flumazenil; gamma-Aminobutyric Acid; Humans; Male; Occipital Lobe; Receptors, GABA; Receptors, GABA-A; Tomography, Emission-Computed, Single-Photon | 2003 |
Benzodiazepine-sensitive GABA(A) receptors in the commissural subnucleus of the NTS are involved in the carotid chemoreceptor reflex in rats.
Topics: Animals; Blood Pressure; Carotid Arteries; Chemoreceptor Cells; Diazepam; Flumazenil; GABA Antagonists; gamma-Aminobutyric Acid; Male; Phrenic Nerve; Rats; Rats, Wistar; Receptors, GABA-A; Reflex; Solitary Nucleus; Synaptic Transmission; Visceral Afferents | 2004 |
Flumazenil-independent positive modulation of gamma-aminobutyric acid action by 6-methylflavone at human recombinant alpha1beta2gamma2L and alpha1beta2 GABAA receptors.
Topics: Allosteric Regulation; Animals; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Female; Flavones; Flavonoids; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Gene Expression; Humans; Membrane Potentials; Microinjections; Molecular Structure; Oocytes; Protein Subunits; Receptors, GABA; Receptors, GABA-A; Recombinant Proteins; RNA; Xenopus laevis | 2004 |
Characterization of the interaction of indiplon, a novel pyrazolopyrimidine sedative-hypnotic, with the GABAA receptor.
Topics: Acetamides; Animals; Azides; Benzodiazepines; Binding Sites; Brain; Cell Membrane; Cerebellum; Cerebral Cortex; Chloride Channels; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Kinetics; Male; Pyridines; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Thiophenes; Triazolam; Tritium; Zolpidem | 2004 |
Chronic exposure of cells expressing recombinant GABAA receptors to benzodiazepine antagonist flumazenil enhances the maximum number of benzodiazepine binding sites.
Topics: Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cell Membrane; Diazepam; Dose-Response Relationship, Drug; Drug Combinations; Flumazenil; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Humans; Kidney; Ligands; Receptors, GABA-A; Recombinant Proteins; Tritium | 2004 |
Classic benzodiazepines modulate the open-close equilibrium in alpha1beta2gamma2L gamma-aminobutyric acid type A receptors.
Topics: Algorithms; Animals; Benzodiazepines; Binding Sites; Carbolines; Cattle; Electrophysiology; Flumazenil; GABA Agonists; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Ligands; Midazolam; Oocytes; Patch-Clamp Techniques; Plasmids; Xenopus laevis | 2005 |
6-Methylflavanone, a more efficacious positive allosteric modulator of gamma-aminobutyric acid (GABA) action at human recombinant alpha2beta2gamma2L than at alpha1beta2gamma2L and alpha1beta2 GABA(A) receptors expressed in Xenopus oocytes.
Topics: Allosteric Regulation; Animals; Diazepam; DNA, Recombinant; Dose-Response Relationship, Drug; Female; Flavanones; Flavones; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Gene Expression; Humans; Membrane Potentials; Microinjections; Oocytes; Protein Isoforms; Receptors, GABA-A; RNA; Xenopus laevis | 2005 |
Characterization in rats of the anxiolytic potential of ELB139 [1-(4-chlorophenyl)-4-piperidin-1-yl-1,5-dihydro-imidazol-2-on], a new agonist at the benzodiazepine binding site of the GABAA receptor.
Topics: Animals; Anti-Anxiety Agents; Binding Sites; Binding, Competitive; Conflict, Psychological; Diazepam; Drug Tolerance; Flumazenil; Flunitrazepam; GABA Agonists; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Imidazoles; Light; Male; Membrane Potentials; Patch-Clamp Techniques; Piperidines; Rats; Rats, Wistar | 2005 |
Resuscitative effect of a gamma-aminobutyric acid B receptor antagonist on gamma-hydroxybutyric acid mortality in mice.
Topics: Animals; Benzocycloheptenes; Bicuculline; Drug Overdose; Flumazenil; GABA Antagonists; gamma-Aminobutyric Acid; Male; Mice; Morpholines; Naltrexone; Neuroprotective Agents; Neurotransmitter Agents; Survival Rate; Taurine | 2005 |
Changes in hippocampal GABAA receptor subunit composition in bipolar 1 disorder.
Topics: Adult; Aged; Binding, Competitive; Bipolar Disorder; Brain Chemistry; Clonazepam; Female; Flumazenil; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; Humans; Male; Middle Aged; Muscimol; Protein Subunits; Pyridines; Radioligand Assay; Receptors, GABA-A; Schizophrenia; Zolpidem | 2005 |
Pharmacological properties of GABAA receptors containing gamma1 subunits.
Topics: Animals; Azepines; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Midazolam; Oocytes; Protein Subunits; Pyrazoles; Receptors, GABA-A; Triazolam; Xenopus laevis | 2006 |
Abnormal benzodiazepine receptor function in the depressive-like behavior of diabetic mice.
Topics: Animals; Behavior, Animal; Carbolines; Depression; Diabetes Mellitus, Experimental; Flumazenil; gamma-Aminobutyric Acid; Hindlimb Suspension; Male; Mice; Mice, Inbred ICR; Motor Activity; Receptors, GABA-A | 2005 |
Protective effect of BR-16A, a polyherbal preparation against social isolation stress: possible GABAergic mechanism.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Female; Flumazenil; GABA Agonists; gamma-Aminobutyric Acid; Male; Mice; Motor Activity; Pain; Pentobarbital; Phytotherapy; Plant Extracts; Social Isolation; Stress, Psychological | 2006 |
Low-dose alcohol actions on alpha4beta3delta GABAA receptors are reversed by the behavioral alcohol antagonist Ro15-4513.
Topics: Animals; Azides; Benzodiazepines; Carbolines; Electrophysiology; Esters; Ethanol; Flumazenil; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Molecular Structure; Mutation; Oocytes; Patch-Clamp Techniques; Protein Subunits; Receptors, GABA-A; Xenopus laevis | 2006 |
Focal cortical dysplasia: pathophysiological approach.
Topics: Adolescent; Animals; Animals, Newborn; Autoradiography; Behavior, Animal; Brain Diseases; Brain Mapping; Cerebral Cortex; Child; Electroencephalography; Epilepsy; Female; Flumazenil; gamma-Aminobutyric Acid; Humans; Immunohistochemistry; Iodine Radioisotopes; Kainic Acid; Male; Nervous System Malformations; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2006 |
Felbamate is a subunit selective modulator of recombinant gamma-aminobutyric acid type A receptors expressed in Xenopus oocytes.
Topics: Animals; Cells, Cultured; Cerebellum; Diazepam; DNA, Recombinant; Felbamate; Female; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Gene Expression; Humans; Membrane Potentials; Oocytes; Patch-Clamp Techniques; Phenylcarbamates; Plasmids; Propylene Glycols; Protein Subunits; Receptors, GABA-A; Xenopus laevis | 2006 |
Zolpidem modulates GABA(A) receptor function in subthalamic nucleus.
Topics: Animals; Flumazenil; GABA Agonists; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Motor Activity; Neural Inhibition; Neural Pathways; Neurons; Organ Culture Techniques; Parkinson Disease; Patch-Clamp Techniques; Pyridines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, GABA-A; Subthalamic Nucleus; Synaptic Transmission; Time Factors; Zolpidem | 2007 |
Allosteric uncoupling and up-regulation of benzodiazepine and GABA recognition sites following chronic diazepam treatment of HEK 293 cells stably transfected with alpha1beta2gamma2S subunits of GABA (A) receptors.
Topics: Allosteric Regulation; Animals; Benzodiazepines; Binding Sites; Binding, Competitive; Cell Line; Diazepam; Flumazenil; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Muscimol; Picrotoxin; Protein Subunits; Pyridazines; Radioligand Assay; Rats; Receptors, GABA-A; Receptors, GABA-B; Transfection; Up-Regulation | 2007 |
Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism.
Topics: Animals; Drug Synergism; Drugs, Chinese Herbal; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Male; Mice; Mice, Inbred ICR; Motor Activity; Pentobarbital; Rats; Rats, Sprague-Dawley; Reishi; Sleep; Sleep, REM | 2007 |
Flumazenil selectively prevents the increase in alpha(4)-subunit gene expression and an associated change in GABA(A) receptor function induced by ethanol withdrawal.
Topics: Acetamides; Alcohol-Induced Disorders, Nervous System; Animals; Animals, Newborn; Anticonvulsants; Cells, Cultured; Central Nervous System Depressants; Drug Interactions; Drug Tolerance; Ethanol; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Gene Expression Regulation; Neuronal Plasticity; Patch-Clamp Techniques; Protein Subunits; Pyrimidines; Rats; Receptors, GABA-A; Substance Withdrawal Syndrome; Up-Regulation | 2007 |
Anxiolytic-like effects of sinapic acid in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Bicuculline; Cerebral Cortex; Chloride Channels; Coumaric Acids; Diazepam; Electrophysiology; Flumazenil; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred ICR; Motor Activity; Muscle Relaxation; Muscle, Smooth; Neurons; Neurotransmitter Agents; Piperazines; Postural Balance; Pyridines; Serotonin Antagonists | 2007 |
Valerenic acid potentiates and inhibits GABA(A) receptors: molecular mechanism and subunit specificity.
Topics: Animals; Chloride Channels; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Indenes; Membrane Potentials; Mutation; Oocytes; Patch-Clamp Techniques; Protein Subunits; Receptors, GABA-A; Sesquiterpenes; Xenopus laevis | 2007 |
Open-label study of a proprietary treatment program targeting type A gamma-aminobutyric acid receptor dysregulation in methamphetamine dependence.
Topics: Adolescent; Adult; Aged; Amines; Cyclohexanecarboxylic Acids; Female; Flumazenil; Gabapentin; gamma-Aminobutyric Acid; Humans; Hydroxyzine; Male; Methamphetamine; Middle Aged; Patient Dropouts; Prospective Studies; Receptors, GABA; Substance-Related Disorders | 2007 |
Reduced GABA neurotransmission underlies hyperalgesia induced by repeated forced swimming stress.
Topics: Analysis of Variance; Animals; Diazepam; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Hyperalgesia; Male; Microdialysis; Pain; Pain Threshold; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Spinal Cord; Stress, Psychological; Swimming | 2008 |
Anticonvulsive effects of intracerebroventricular administration of rutin in rats.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clonic; Flumazenil; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Injections, Intraventricular; Male; Pentylenetetrazole; Rats; Rats, Wistar; Rutin; Seizures | 2008 |
Short-term plasticity of central benzodiazepine receptors in status epilepticus: case report.
Topics: Aged; Biomarkers; Brain; Brain Mapping; Down-Regulation; Female; Flumazenil; gamma-Aminobutyric Acid; Humans; Iodine Radioisotopes; Magnetic Resonance Imaging; Neural Inhibition; Neuronal Plasticity; Predictive Value of Tests; Receptors, GABA-A; Status Epilepticus; Synaptic Transmission; Time Factors; Tomography, Emission-Computed, Single-Photon | 2008 |
Saturation assays of radioligand binding to receptors and their allosteric modulatory sites.
Topics: Allosteric Site; Animals; Binding Sites; Binding, Competitive; Flumazenil; gamma-Aminobutyric Acid; Ligands; Muscimol; Nerve Tissue Proteins; Protein Binding; Radioligand Assay; Rats; Receptors, GABA-A; Tritium | 2001 |
Tiagabine increases [11C]flumazenil binding in cortical brain regions in healthy control subjects.
Topics: Adult; Brain Mapping; Cerebral Cortex; Cognition; Cortical Synchronization; Feasibility Studies; Female; Flumazenil; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Positron-Emission Tomography; Receptors, GABA-A; Tiagabine | 2009 |
Intra-periaqueductal gray matter injections of midazolam fail to alter anxiety in plus-maze experienced mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Anxiety Disorders; Avoidance Learning; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Fear; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Male; Maze Learning; Mice; Midazolam; Neural Inhibition; Periaqueductal Gray; Receptors, GABA-A; Synaptic Transmission | 2008 |
Flavan-3-ol derivatives are positive modulators of GABA(A) receptors with higher efficacy for the alpha(2) subtype and anxiolytic action in mice.
Topics: Adaptation, Ocular; Analysis of Variance; Animals; Anti-Anxiety Agents; Behavior, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Flavonoids; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Humans; Male; Maze Learning; Membrane Potentials; Mice; Motor Activity; Oocytes; Protein Binding; Receptors, GABA-A; Recombinant Fusion Proteins; Reflex; Stereoisomerism; Thiopental; Xenopus laevis | 2008 |
Selective activation of metabotropic G-protein-coupled glutamate 7 receptor elicits anxiolytic-like effects in mice by modulating GABAergic neurotransmission.
Topics: Animals; Arousal; Benzhydryl Compounds; Body Temperature Regulation; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pain Threshold; Reaction Time; Receptors, Metabotropic Glutamate; Stress, Psychological; Synaptic Transmission | 2008 |
GABAA receptor alpha5 subunits contribute to GABAA,slow synaptic inhibition in mouse hippocampus.
Topics: Animals; Biophysical Phenomena; Biophysics; Diazepam; Electric Stimulation; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Mice; Mice, Transgenic; Neural Inhibition; Patch-Clamp Techniques; Point Mutation; Pyramidal Cells; Receptors, GABA-A; Synapses | 2009 |
A high-throughput functional assay for characterization of gamma-aminobutyric acid(A) channel modulators using cryopreserved transiently transfected cells.
Topics: Carbolines; Cell Culture Techniques; Cell Line; Cell Membrane; Cryopreservation; Diazepam; DNA; Dose-Response Relationship, Drug; Drug Discovery; Flumazenil; Flunitrazepam; Fluorescent Dyes; Fluorobenzenes; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Membrane Potentials; Receptors, GABA-A; Reproducibility of Results; Spectrometry, Fluorescence; Transfection; Triazoles; Tritium | 2008 |
Kaempferol from the leaves of Apocynum venetum possesses anxiolytic activities in the elevated plus maze test in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Apocynum; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Kaempferols; Male; Maze Learning; Mice; Mice, Inbred BALB C; Phytotherapy; Piperazines; Plant Extracts; Plant Leaves; Pyridines | 2009 |
The group III mGlu receptor agonist ACPT-I exerts anxiolytic-like but not antidepressant-like effects, mediated by the serotonergic and GABA-ergic systems.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Cyclopentanes; Depression; Flumazenil; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Male; Piperazines; Pyridines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Ritanserin; Serotonin; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Stress, Psychological; Tricarboxylic Acids | 2009 |
Effects of isopulegol on pentylenetetrazol-induced convulsions in mice: possible involvement of GABAergic system and antioxidant activity.
Topics: Animals; Anticonvulsants; Antioxidants; Catalase; Cyclohexane Monoterpenes; Dose-Response Relationship, Drug; Drug Interactions; Flumazenil; gamma-Aminobutyric Acid; Glutathione; Hippocampus; Lipid Peroxidation; Male; Mice; Pentylenetetrazole; Phytotherapy; Plant Extracts; Receptors, GABA-A; Seizures; Terpenes | 2009 |
Decreased GABA-A binding on FMZ-PET in succinic semialdehyde dehydrogenase deficiency.
Topics: Adolescent; Adult; Brain; Carbon Radioisotopes; Child; Female; Flumazenil; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Positron-Emission Tomography; Protein Binding; Receptors, GABA-A; Succinate-Semialdehyde Dehydrogenase; Young Adult | 2009 |
Relative positioning of diazepam in the benzodiazepine-binding-pocket of GABA receptors.
Topics: Allosteric Regulation; Animals; Anti-Anxiety Agents; Benzodiazepines; Binding Sites; Biophysics; Cell Line, Transformed; Cysteine; Diazepam; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electric Stimulation; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Humans; Membrane Potentials; Oocytes; Point Mutation; Protein Binding; Receptors, GABA-A; Structure-Activity Relationship; Transfection; Xenopus | 2009 |
Ecophysiology of neuronal metabolism in transiently oxygen-depleted environments: evidence that GABA is accumulated pre-synaptically in the cerebellum.
Topics: Acclimatization; Animals; Cerebellum; Chromatography, High Pressure Liquid; Energy Metabolism; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Glutamic Acid; Hypoxia; Immunohistochemistry; Neuronal Plasticity; Neurons; Oxygen; Presynaptic Terminals; Radioligand Assay; Receptors, GABA-A; Sharks | 2010 |
Flumazenil administration attenuates cognitive impairment in immature rats after controlled cortical impact.
Topics: Animals; Brain; Brain Chemistry; Brain Injuries; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Male; Maze Learning; Nootropic Agents; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, GABA-A; Treatment Outcome | 2010 |
GABAergic dysfunction in essential tremor: an 11C-flumazenil PET study.
Topics: Aged; Brain; Cerebellum; Essential Tremor; Female; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Motor Cortex; Neural Pathways; Positron-Emission Tomography; Radiopharmaceuticals; Receptors, GABA-A; Thalamus | 2010 |
Metabotropic glutamate receptor 4 novel agonist LSP1-2111 with anxiolytic, but not antidepressant-like activity, mediated by serotonergic and GABAergic systems.
Topics: Aminobutyrates; Animals; Anti-Anxiety Agents; Antidepressive Agents; Diazepam; Fever; Flumazenil; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Maze Learning; Mice; Phosphinic Acids; Piperazines; Pyridines; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptors, GABA-A; Receptors, Metabotropic Glutamate; Ritanserin; Serotonin; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT2 Receptor Agonists; Stress, Psychological | 2010 |
The GABAA receptor alpha+beta- interface: a novel target for subtype selective drugs.
Topics: Analysis of Variance; Animals; Binding Sites; Dose-Response Relationship, Drug; Electrophysiology; Flumazenil; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Protein Subunits; Pyrazoles; Receptors, GABA-A; Xenopus laevis | 2011 |
Human stiff-person syndrome IgG induces anxious behavior in rats.
Topics: Adult; Amygdala; Animals; Anxiety; Behavior, Animal; Carbon Radioisotopes; Cells, Cultured; Female; Flumazenil; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hippocampus; Humans; Immunoglobulin G; Middle Aged; Neurons; Positron-Emission Tomography; Rats; Stiff-Person Syndrome; Young Adult | 2011 |
Possible involvement of GABAergic mechanism in protective effect of melatonin against sleep deprivation-induced behavior modification and oxidative damage in mice.
Topics: Animals; Antioxidants; Anxiety; Behavior, Animal; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Lipid Peroxidation; Male; Melatonin; Mice; Motor Activity; Muscimol; Oxidative Stress; Picrotoxin; Sleep Deprivation | 2011 |
Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord.
Topics: Analgesics; Animals; Diazepam; Disease Models, Animal; Excitatory Postsynaptic Potentials; Flumazenil; Formaldehyde; GABA Modulators; gamma-Aminobutyric Acid; Glutamic Acid; Hyperalgesia; Ketamine; Male; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Stress, Psychological; Swimming; Time Factors | 2011 |
3-Hydroxy-2'-methoxy-6-methylflavone: a potent anxiolytic with a unique selectivity profile at GABA(A) receptor subtypes.
Topics: Animals; Anti-Anxiety Agents; Diazepam; Dose-Response Relationship, Drug; Fatty Acids, Volatile; Flavones; Flumazenil; gamma-Aminobutyric Acid; Humans; Male; Mice; Mice, Inbred BALB C; Molecular Structure; Motor Activity; Oocytes; Pentylenetetrazole; Receptors, GABA-A; Recombinant Proteins; Thiopental; Xenopus | 2011 |
Decreased benzodiazepine receptor and increased GABA level in cortical tubers in tuberous sclerosis complex.
Topics: Aspartic Acid; Brain; Case-Control Studies; Child; Child, Preschool; Female; Flumazenil; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Inositol; Iodine Radioisotopes; Magnetic Resonance Spectroscopy; Male; Protons; Radiopharmaceuticals; Receptors, GABA-A; Tomography, Emission-Computed, Single-Photon; Tuberous Sclerosis | 2012 |
Evaluation of the GABAergic nervous system in autistic brain: (123)I-iomazenil SPECT study.
Topics: Adolescent; Brain; Child; Child Development Disorders, Pervasive; Child, Preschool; Flumazenil; gamma-Aminobutyric Acid; Humans; Iodine Radioisotopes; Radiopharmaceuticals; Tomography, Emission-Computed, Single-Photon | 2012 |
Neuroradiological and neurofunctional examinations for patients with 22q11.2 deletion.
Topics: Case-Control Studies; Child; Child, Preschool; DiGeorge Syndrome; Electroencephalography; Epilepsy; Female; Flumazenil; gamma-Aminobutyric Acid; Humans; Hydrogen; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Malformations of Cortical Development; Radiography; Tomography, Emission-Computed, Single-Photon | 2011 |
[Ketogenic diet may control seizures by increasing the binding potential of the benzodiazepine receptor: a speculation from the [11C] flumazenil-PET study].
Topics: Brain; Carbon Radioisotopes; Child, Preschool; Diet, Ketogenic; Epilepsy, Frontal Lobe; Female; Flumazenil; gamma-Aminobutyric Acid; Humans; Positron-Emission Tomography; Radiopharmaceuticals; Receptors, GABA; Receptors, GABA-A | 2012 |
[11C]flumazenil binding is increased in a dose-dependent manner with tiagabine-induced elevations in GABA levels.
Topics: Adult; Carbon Isotopes; Cognition; Dose-Response Relationship, Drug; Electroencephalography; Electrophysiology; Female; Flumazenil; GABA Modulators; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; Ligands; Male; Models, Statistical; Nipecotic Acids; Positron-Emission Tomography; Regression Analysis; Tiagabine | 2012 |
Neuroprotective effects of vitexin, a flavonoid, on pentylenetetrazole-induced seizure in rats.
Topics: Animals; Anticonvulsants; Apigenin; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Male; Neuroprotective Agents; Pennisetum; Pentylenetetrazole; Rats; Rats, Wistar; Seizures | 2012 |
Widespread abnormality of the γ-aminobutyric acid-ergic system in Tourette syndrome.
Topics: Adult; Brain; Carbon Isotopes; Case-Control Studies; Female; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Humans; Male; Neural Pathways; Positron-Emission Tomography; Protein Binding; Receptors, GABA-A; Tourette Syndrome; Young Adult | 2012 |
Gaba and serotonin molecular neuroimaging in essential tremor: a clinical correlation study.
Topics: Aged; Cerebellum; Essential Tremor; Female; Flumazenil; gamma-Aminobutyric Acid; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Neuroimaging; Parkinson Disease; Positron-Emission Tomography; Radiography; Serotonin | 2012 |
Ubiquitin-specific peptidase 46 (Usp46) regulates mouse immobile behavior in the tail suspension test through the GABAergic system.
Topics: Animals; Base Sequence; Blotting, Northern; DNA Primers; Endopeptidases; Flumazenil; gamma-Aminobutyric Acid; Hindlimb Suspension; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrazepam; Tail | 2012 |
Antipsychotic and sedative effects of the leaf extract of Crassocephalum bauchiense (Hutch.) Milne-Redh (Asteraceae) in rodents.
Topics: Animals; Antipsychotic Agents; Apomorphine; Asteraceae; Behavior, Animal; Body Temperature; Brain; Catalepsy; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Agents; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Male; Medicine, African Traditional; Mice; Mice, Inbred Strains; Motor Activity; Pentobarbital; Phytotherapy; Plant Extracts; Plant Leaves; Psychotic Disorders; Rats, Sprague-Dawley; Receptors, GABA-A; Sleep; Valproic Acid | 2012 |
External awareness and GABA--a multimodal imaging study combining fMRI and [18F]flumazenil-PET.
Topics: Adolescent; Adult; Awareness; Brain; Brain Mapping; Female; Flumazenil; Fluorine Radioisotopes; gamma-Aminobutyric Acid; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Multimodal Imaging; Positron-Emission Tomography; Radiopharmaceuticals; Young Adult | 2014 |
Neurounina-1, a novel compound that increases Na+/Ca2+ exchanger activity, effectively protects against stroke damage.
Topics: Animals; Benzodiazepinones; Calcium; Cell Death; Cells, Cultured; Cricetinae; Dogs; Flumazenil; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred C57BL; Mitochondria; Mutation; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Pyrrolidines; Rats; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Sodium-Calcium Exchanger; Stroke; Synaptosomes | 2013 |
GABAergic changes in (11)C-flumazenil PET in the drug-naïve Stiff-Person syndrome.
Topics: Adult; Carbon Radioisotopes; Female; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Humans; Immunoglobulins, Intravenous; Magnetic Resonance Spectroscopy; Positron-Emission Tomography; Stiff-Person Syndrome | 2013 |
Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms.
Topics: Alkaloids; Amino Acids; Animals; Anticonvulsants; Antioxidants; Atropine; Benzodioxoles; Biogenic Monoamines; Brain; Diazepam; Disease Models, Animal; Epilepsy; Flumazenil; gamma-Aminobutyric Acid; Humans; Male; Memantine; Mice; Nimodipine; Nitrites; Pilocarpine; Piperidines; Polyunsaturated Alkamides; Seizures; Tumor Necrosis Factor-alpha | 2013 |
Reduced binding potential of GABA-A/benzodiazepine receptors in individuals at ultra-high risk for psychosis: an [18F]-fluoroflumazenil positron emission tomography study.
Topics: Adolescent; Brain; Case-Control Studies; Caudate Nucleus; Female; Flumazenil; gamma-Aminobutyric Acid; Hippocampus; Humans; Male; Nucleus Accumbens; Parahippocampal Gyrus; Positron-Emission Tomography; Prodromal Symptoms; Protein Binding; Putamen; Receptors, GABA-A; Risk; Schizophrenia; Young Adult | 2014 |
Monocyte Chemoattractant Protein-1 upregulates GABA-induced current: evidence of modified GABAA subunit composition in cortical neurons from the G93A mouse model of Amyotrophic Lateral Sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cells, Cultured; Cerebral Cortex; Chemokine CCL2; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Flumazenil; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Male; Membrane Potentials; Mice; Mice, Transgenic; Neurons; Protein Subunits; Receptors, GABA-A; Spinal Cord | 2013 |
Potentiating effect of glabridin on GABAA receptor-mediated responses in dorsal raphe neurons.
Topics: Animals; Anti-Anxiety Agents; Brain; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GABA Agents; gamma-Aminobutyric Acid; Glycyrrhiza; Hypnotics and Sedatives; Isoflavones; Neurons; Pentobarbital; Phenols; Plant Extracts; Plant Roots; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Zolpidem | 2013 |
Awake nonhuman primate brain PET imaging with minimal head restraint: evaluation of GABAA-benzodiazepine binding with 11C-flumazenil in awake and anesthetized animals.
Topics: Anesthesia; Animals; Benzodiazepines; Brain; Carbon Radioisotopes; Female; Flumazenil; gamma-Aminobutyric Acid; Head; Macaca mulatta; Male; Positron-Emission Tomography; Restraint, Physical; Wakefulness | 2013 |
Evaluation of frame-based and event-by-event motion-correction methods for awake monkey brain PET imaging.
Topics: Algorithms; Animals; Artifacts; Brain; Flumazenil; gamma-Aminobutyric Acid; Image Processing, Computer-Assisted; Ligands; Macaca mulatta; Models, Statistical; Motion; Phantoms, Imaging; Positron-Emission Tomography; Reproducibility of Results; Time Factors; Wakefulness | 2014 |
Antidepressant and anxiolytic effects of the methanol root extract of Capparis thonningii: involvement of monoaminergic, cholinergic and GABAergic systems.
Topics: Adrenergic Antagonists; Animals; Anti-Anxiety Agents; Antidepressive Agents; Atropine; Behavior, Animal; Biogenic Monoamines; Capparis; Cholinergic Agents; Cholinergic Neurons; Cyproheptadine; Dopamine Antagonists; Female; Flumazenil; GABA Agents; gamma-Aminobutyric Acid; Immobility Response, Tonic; Male; Metergoline; Methanol; Mice; Muscarinic Antagonists; Plant Extracts; Plant Roots; Prazosin; Serotonin Antagonists; Sulpiride; Yohimbine | 2015 |
GABA and 5-HT systems are implicated in the anxiolytic-like effect of spinosin in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Drugs, Chinese Herbal; Flavonoids; Flumazenil; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Male; Maze Learning; Mice; Mice, Inbred ICR; Motor Activity; Piperazines; Pyridines; Receptor, Serotonin, 5-HT1A; Receptors, GABA-A; Serotonin; Serotonin 5-HT1 Receptor Antagonists | 2015 |
Cortical oscillatory dynamics and benzodiazepine-site modulation of tonic inhibition in fast spiking interneurons.
Topics: Action Potentials; Animals; Beta Rhythm; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Interneurons; Kinetics; Male; Models, Neurological; Patch-Clamp Techniques; Pyramidal Cells; Pyridines; Rats, Wistar; Receptors, GABA-A; Tissue Culture Techniques; Zolpidem | 2015 |
Positive modulation of synaptic and extrasynaptic GABAA receptors by an antagonist of the high affinity benzodiazepine binding site.
Topics: Allosteric Regulation; Animals; Benzodiazepines; Binding Sites; Diazepam; Flumazenil; GABA Agents; gamma-Aminobutyric Acid; HEK293 Cells; Humans; Membrane Potentials; Mutation; Neurons; Oocytes; Patch-Clamp Techniques; Protein Isoforms; Quinolines; Radioligand Assay; Receptors, GABA-A; Recombinant Proteins; Thiazoles; Transfection; Xenopus laevis | 2015 |
In vivo measurement of GABA transmission in healthy subjects and schizophrenia patients.
Topics: Adult; Carbon Radioisotopes; Case-Control Studies; Cerebral Cortex; Female; Flumazenil; GABA Modulators; GABA Plasma Membrane Transport Proteins; Gamma Rhythm; gamma-Aminobutyric Acid; Humans; Male; Neuropsychological Tests; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Positron-Emission Tomography; Schizophrenia; Schizophrenic Psychology; Synaptic Transmission; Temporal Lobe; Tiagabine; Young Adult | 2015 |
Bud extracts from Tilia tomentosa Moench inhibit hippocampal neuronal firing through GABAA and benzodiazepine receptors activation.
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Dose-Response Relationship, Drug; Flumazenil; gamma-Aminobutyric Acid; Hippocampus; Hypnotics and Sedatives; Mice; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Picrotoxin; Plant Extracts; Receptors, GABA-A; Tilia | 2015 |
Effects of the ornidazole enantiomers on the central nervous system: Involvement of the GABAA receptor.
Topics: Animals; Brain; Central Nervous System; Flumazenil; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Male; Mice, Inbred ICR; Ornidazole; Receptors, GABA-A; Rotarod Performance Test; Stereoisomerism | 2015 |
Gamma oscillations in V1 are correlated with GABA(A) receptor density: A multi-modal MEG and Flumazenil-PET study.
Topics: Adult; Female; Flumazenil; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Imaging; Magnetoencephalography; Male; Positron-Emission Tomography; Receptors, GABA-A; Visual Cortex | 2015 |
Flumazenil decreases surface expression of α4β2δ GABAA receptors by increasing the rate of receptor internalization.
Topics: Botulinum Toxins, Type A; Cell Membrane; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Dynamins; Flumazenil; GABA Agonists; gamma-Aminobutyric Acid; HEK293 Cells; Humans; Hydrazones; Immunohistochemistry; Isoxazoles; Leupeptins; Membrane Potentials; Patch-Clamp Techniques; Receptors, GABA-A; Recombinant Proteins; Transfection | 2016 |
Negative allosteric modulation of GABAA receptors inhibits facilitation of brain stimulation reward by drugs of abuse in C57BL6/J mice.
Topics: Allosteric Regulation; Animals; Azides; Benzodiazepines; Brain; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Illicit Drugs; Male; Mice; Mice, Inbred C57BL; Microdialysis; Receptors, GABA-A; Reward; Self Stimulation | 2016 |
The Differential Effects of Resveratrol and trans-ε-Viniferin on the GABA-Induced Current in GABAA Receptor Subtypes Expressed in Xenopus Laevis Oocytes.
Topics: Animals; Benzofurans; Binding Sites; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Humans; Imidazoles; Inhibitory Concentration 50; Oocytes; Patch-Clamp Techniques; Receptors, GABA-A; Resveratrol; Stilbenes; Xenopus laevis | 2015 |
GABA deficiency in NF1: A multimodal [11C]-flumazenil and spectroscopy study.
Topics: Adult; Brain; Case-Control Studies; Cross-Sectional Studies; Female; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neurofibromatosis 1; Neuropsychological Tests; Positron-Emission Tomography; Protein Binding; Receptors, GABA-A | 2016 |
Flumazenil Modulation of the γ-Aminobutyric Acid Type A Receptor: Competitive versus Noncompetitive Antagonism at the Agonist-binding Site.
Topics: Binding Sites; Binding, Competitive; Flumazenil; gamma-Aminobutyric Acid; Receptors, GABA; Receptors, GABA-A | 2017 |
Curcumol allosterically modulates GABA(A) receptors in a manner distinct from benzodiazepines.
Topics: Allosteric Regulation; Animals; Benzodiazepines; CA1 Region, Hippocampal; Cells, Cultured; Diazepam; Drugs, Chinese Herbal; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; HEK293 Cells; Humans; Membrane Potentials; Pyramidal Cells; Receptors, GABA-A; Sesquiterpenes | 2017 |
Selective inhibition of extra-synaptic α5-GABA
Topics: Animals; Benzodiazepines; Binding, Competitive; Brain; Female; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; HEK293 Cells; Humans; Long-Term Potentiation; Male; Memory; Mice, Inbred C57BL; Muscimol; Neural Inhibition; Nootropic Agents; Oxazoles; Rats, Sprague-Dawley; Receptors, GABA-A; Tissue Culture Techniques | 2017 |
The anxiolytic-like effect of 6-styryl-2-pyrone in mice involves GABAergic mechanism of action.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Hippocampus; Imipramine; Male; Mice; Pyrones; Styrenes | 2018 |
Vascular-metabolic and GABAergic Inhibitory Correlates of Neural Variability Modulation. A Combined fMRI and PET Study.
Topics: Adult; Cerebrovascular Circulation; Female; Flumazenil; Fluorodeoxyglucose F18; GABA Modulators; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multimodal Imaging; Occipital Lobe; Oxygen; Periodicity; Positron-Emission Tomography; Radiopharmaceuticals; Receptors, GABA-A; Young Adult | 2018 |
Structure of a human synaptic GABA
Topics: Benzodiazepines; Bicuculline; Binding, Competitive; Brain Chemistry; Cell Membrane; Cryoelectron Microscopy; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Glycosylation; HEK293 Cells; Humans; Immunoglobulin Fab Fragments; Ligands; Models, Molecular; Receptors, GABA-A | 2018 |
Gelsedine-type alkaloids: Discovery of natural neurotoxins presented in toxic honey.
Topics: Animals; Antidotes; Biological Availability; Female; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Glucuronides; Honey; Hydroxylation; Indole Alkaloids; Lethal Dose 50; Male; Mice, Inbred ICR; Neurotoxins; Picrotoxin; Rats, Sprague-Dawley | 2020 |
Shared structural mechanisms of general anaesthetics and benzodiazepines.
Topics: Allosteric Regulation; Anesthetics, General; Barbiturates; Benzodiazepines; Bicuculline; Binding Sites; Binding, Competitive; Cryoelectron Microscopy; Diazepam; Electrophysiology; Etomidate; Flumazenil; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Ligands; Models, Molecular; Molecular Conformation; Molecular Dynamics Simulation; Phenobarbital; Picrotoxin; Propofol; Receptors, GABA-A | 2020 |
In vivo gamma-aminobutyric acid-A/benzodiazepine receptor availability and genetic liability in asymptomatic individuals with high genetic loading of schizophrenia: A [11C]flumazenil positron emission tomography study.
Topics: Brain; Carbon Radioisotopes; Flumazenil; gamma-Aminobutyric Acid; Humans; Positron-Emission Tomography; Receptors, GABA-A; Schizophrenia | 2021 |
High-Dose Benzodiazepines Positively Modulate GABA
Topics: Animals; Animals, Outbred Strains; Benzodiazepines; Clonazepam; Diazepam; Female; Flumazenil; GABA Antagonists; gamma-Aminobutyric Acid; Male; Mice; Midazolam; Receptors, GABA-A; Xenopus laevis | 2021 |
A theory of the anxiolytic action of flumazenil in anxiety disorders.
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Flumazenil; gamma-Aminobutyric Acid; Humans; Hypothalamo-Hypophyseal System; Pituitary-Adrenal System; Pregnanolone; Receptors, GABA-A | 2022 |
Imidazobenzodiazepine PI320 Relaxes Mouse Peripheral Airways by Inhibiting Calcium Mobilization.
Topics: Animals; Asthma; Calcium; Calcium Signaling; Flumazenil; gamma-Aminobutyric Acid; Inositol; Ligands; Lung; Methacholine Chloride; Mice; Muscle Contraction; Muscle, Smooth; Picrotoxin | 2022 |
Inhibition of GABAA receptors in intestinal stem cells prevents chemoradiotherapy-induced intestinal toxicity.
Topics: Animals; Bicuculline; Calcium; Chemoradiotherapy; Flumazenil; gamma-Aminobutyric Acid; Humans; Intestines; Mice; Reactive Oxygen Species; Receptors, GABA-A; Stem Cells; Tumor Suppressor Protein p53; United States | 2022 |
Effective Preparation of [
Topics: Copper; Flumazenil; Fluorine Radioisotopes; gamma-Aminobutyric Acid; Positron-Emission Tomography; Radiopharmaceuticals | 2022 |
Zerumbone, a major sesquiterpene from Syringa pinnatifolia Hemsl., exerts the sedative effect by regulating GABAergic nervous system.
Topics: Animals; Bicuculline; Chlorides; Flumazenil; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Mice; Molecular Docking Simulation; Nervous System; Pentobarbital; Plant Extracts; Rats; Receptors, GABA-A; Sesquiterpenes; Syringa | 2023 |
Anxiolytic-like effects of citral in the mouse elevated plus maze: involvement of GABAergic and serotonergic transmissions.
Topics: Acyclic Monoterpenes; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Elevated Plus Maze Test; Flumazenil; gamma-Aminobutyric Acid; Maze Learning; Mice; Receptor, Serotonin, 5-HT1A | 2023 |
Anxiolytic-like Effect of Quercetin Possibly through GABA Receptor Interaction Pathway: In Vivo and In Silico Studies.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Maze Learning; Mice; Quercetin; Receptors, GABA; Receptors, GABA-A | 2022 |
Commonly Used Therapeutics Associated with Changes in Arousal Inhibit GABA
Topics: Allosteric Regulation; Arousal; Flumazenil; gamma-Aminobutyric Acid; Humans; Receptors, GABA-A | 2023 |
Flumazenil Pretreatment Reduces Mefenamic Acid-Induced Central Nervous System Toxicity in Mice.
Topics: Animals; Behavior, Animal; Catalepsy; Central Nervous System; Flumazenil; gamma-Aminobutyric Acid; Mefenamic Acid; Mice; Receptors, GABA-A; Seizures | 2023 |
Search for Novel Therapies for Essential Tremor Based on Positive Modulation of α6-Containing GABA
Topics: Animals; Essential Tremor; Flumazenil; gamma-Aminobutyric Acid; Harmaline; Humans; Ketamine; Mice; Mice, Knockout; Receptors, GABA-A; Tremor | 2023 |