flumazenil has been researched along with flunitrazepam in 186 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 87 (46.77) | 18.7374 |
| 1990's | 63 (33.87) | 18.2507 |
| 2000's | 27 (14.52) | 29.6817 |
| 2010's | 8 (4.30) | 24.3611 |
| 2020's | 1 (0.54) | 2.80 |
| Authors | Studies |
|---|---|
| Cook, JM; Dayer, CA; He, X; Huang, Q; Liu, R; Ma, C; McKernan, R; Wenger, GR; Yu, S | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Clayton, T; Cook, J; DeLorey, TM; Furtmüller, R; Halliwell, RF; Harris, D; Huck, S; Sahbaie, P; Sieghart, W | 1 |
| Anzini, M; Betti, L; Braile, C; Cappelli, A; Ghelardini, C; Giannaccini, G; Giorgi, G; Ian Fryer, R; Limongelli, V; Lucacchini, A; Makovec, F; Marinelli, L; Norcini, M; Novellino, E; Valenti, S; Vomero, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Alcaro, S; Anzini, M; Betti, L; Biggio, G; Braile, C; Cappelli, A; Daniele, S; Di Cesare Mannelli, L; Ghelardini, C; Giannaccini, G; Giorgi, G; Limongelli, V; Lucacchini, A; Marinelli, L; Martini, C; Mascia, MP; Novellino, E; Ortuso, F; Valenti, S; Vomero, S | 1 |
| Bendinelli, S; Castellano, S; Cosconati, S; Costa, B; Da Pozzo, E; Da Settimo, F; Greco, G; Martini, C; Milite, C; Novellino, E; Pugliesi, I; Rizzetto, E; Sbardella, G; Stefancich, G; Taliani, S | 1 |
| Anzini, M; Betti, L; Biggio, G; Braile, C; Cappelli, A; Castriconi, F; Di Capua, A; Di Cesare Mannelli, L; Frosini, M; Ghelardini, C; Giannaccini, G; Giorgi, G; Giuliani, G; Grisci, G; Lucacchini, A; Mascia, MP; Paolino, M; Ricci, L; Valenti, S; Vomero, S | 1 |
| Bailey, J; Glue, P; Hudson, A; Nutt, DJ; Wilson, S | 1 |
| Kukulka, KM; Mans, AM; McAvoy, KJ; Rokosz, NC | 1 |
| Inoue, O; Kobayashi, K; Sakiyama, Y; Suzuki, T | 1 |
| Davies, MF; Loew, GH; Maguire, PA; Villar, HO | 1 |
| Gobbi, M; Mennini, T | 1 |
| Firestone, LL; Quinlan, JJ | 1 |
| Gibert-Rahola, J; Maldonado, R; Micó, JA; Valverde, O | 1 |
| Davies, MF; Loew, GH; Maguire, PA; Onaivi, ES; Tsai, NF | 1 |
| Carter, DB; Gale, W; Im, HK; Im, WB; Lennon, DJ; Ngo, DM; Seeburg, PH; Smith, MW; Thomsen, DR | 1 |
| Gallaher, EJ; Phillips, TJ | 1 |
| Fiszer de Plazas, S; Gravielle, MC | 1 |
| Cox, P; Gillard, NP; McKernan, RM; Whiting, P | 1 |
| Da Cunha, C; Izquierdo, I; Jerusalinsky, D; Levi de Stein, M; Medina, JH; Viola, H; Wolfman, C | 1 |
| Airaksinen, MM; MacDonald, E; Rägo, L; Saano, V | 1 |
| Farb, DH; Friedman, L; Gibbs, TT; Roca, DJ; Rozenberg, I; Schiller, GD | 1 |
| Aveni, MR; Buzzetti, V; Dellino, E; Dormia, G; Gonnella, G; Iapichino, G; Patelli, E; Ravagnan, R; Russo, R; Veschi, G | 1 |
| Martin, WR; Sloan, JW; Wala, EP | 1 |
| De Luca, C; De Medici, D; Massotti, M | 1 |
| Kataja, J; Kaukinen, L; Kaukinen, S | 1 |
| Doenicke, A; Greim, M; Juhl, G; Rampf, U; Suttmann, H | 1 |
| Desmonts, JM; Foult, JM; Joyon, D; Marty, J; Nitenberg, A; Philip, I | 1 |
| Bonnet, MC; du Cailar, J; Roche, B | 1 |
| Bello, C; Gentil, V; Gorenstein, C; Gronich, G; Mathias, L; Singer, J; Tavares, S | 1 |
| Achtari, R; Baasch, K; Schaer, H | 1 |
| Buck, KJ; Harris, RA | 1 |
| Borden, LA; Gibbs, TT | 1 |
| Kulkarni, SK; Ticku, MK | 1 |
| Danielou, G; Lloyd, GK; Thuret, F | 1 |
| Amaha, K; Hanaoka, K; Kobayashi, K; Nagano, M; Numata, K; Okada, K; Yamamura, H; Yogosawa, T | 1 |
| Havoundjian, H; Skolnick, P; Trullas, R | 1 |
| Greenblatt, DJ; Miller, LG; Roy, RB; Shader, RI; Summer, WR | 1 |
| Costa, E; Mienville, JM; Vicini, S | 1 |
| Blois, R; Gaillard, JM | 2 |
| Camargo, CH; Gentil, V; Gorenstein, C; Singer, JM | 1 |
| Couderc, E; Desmonts, JM; Joyon, D; Lefèvre, P; Marty, J; Scardin, A; Schoeffler, P | 1 |
| Dahl, V; Roald, OK | 1 |
| Delva, E; Just, B; Lienhart, A | 1 |
| Mok, MS; Steen, SN; Tu, KT; Wei, TT | 1 |
| Marczynski, TJ; Urbancic, M | 2 |
| Corradini, S; Fantera, A; Fegiz, A; Iannarone, C; Talarico, A; Tellan, G | 1 |
| Ikeda, H; Robbins, J | 1 |
| Harary, N; Kellogg, C | 1 |
| Lüddens, H; Pritchett, DB; Seeburg, PH | 1 |
| Mhatre, M; Ticku, MK | 1 |
| Dellouve-Courillon, C; Dodd, RH; Lambolez, B; Potier, P | 1 |
| Ikeda, M; Knapp, RJ; Malatynska, E; Yamamura, HI | 1 |
| Bechtel, WD; Ikeda, M; Malatynska, E; Weber, KH; Yamamura, HI | 1 |
| Cox, DH; Guidotti, A; Santi, MR | 1 |
| McCabe, RT; Olsen, RW; Wamsley, JK; Yezuita, JP | 1 |
| Benavides, J; Dubois, A; Morel, E; Peny, B; Perrault, G; Scatton, B; Zivkovic, B | 1 |
| Klotz, U | 1 |
| Wolff, J | 1 |
| Cavellat, M; Dupeyron, JP; Francois, G; Lienhart, A; Motin, J; Richard, JP; Roquefeuil, B; Sabathie, M; Scherpereel, PH; Winckler, C | 1 |
| Amrein, R; Hartmann, D; Hetzel, W; Lorscheid, T | 1 |
| Berg, DK; McEachern, AE | 1 |
| Marley, RJ; Stinchcomb, A; Wehner, JM | 1 |
| Brown, CL; Dodd, RH; Potier, MC; Prado de Carvalho, L; Rossier, J | 1 |
| Hawkins, M; Pravica, M; Radulovacki, M | 1 |
| Chivers, J; Horton, RW; Jenner, P; Lowther, S; Marsden, CD; Testa, B | 1 |
| Basile, AS; Gammal, SH; Jones, EA; Mullen, KD; Skolnick, P | 1 |
| Hofer, P; Scollo-Lavizzari, G | 1 |
| Chweh, AY; Swinyard, EA; Ulloque, RA | 1 |
| Barrett, JE; Mansbach, RS; Skolnick, P; Weissman, BA; Witkin, JM | 1 |
| Ackenheil, M; Doenicke, A; Dorow, R; Duka, T; Noderer, J | 1 |
| Koe, BK; Kondratas, E; Russo, LL | 1 |
| Kuriyama, K; Taguchi, J | 1 |
| Concas, A; Morelli, M; Obata, T; Serra, M; Yamamura, HI | 1 |
| Fillenz, M; Fung, SC | 1 |
| Bold, JM; Gardner, CR; Walker, RJ | 1 |
| Kempner, ES; Paul, SM; Schwartz, RD; Skolnick, P; Thomas, JW | 1 |
| Goeders, NE; Kuhar, MJ | 1 |
| Hammond, JR | 1 |
| Abraham, CJ; De Blas, AL; Haney, SA; Park, D; Rayner, CA; Sangameswaran, L | 1 |
| Haefely, W; Möhler, H; Richards, JG; Schoch, P | 1 |
| Cohen, RM; Havoundjian, H; Paul, SM; Skolnick, P | 1 |
| Sweetnam, PM; Tallman, JF | 1 |
| Morin, AM | 1 |
| Biziere, K; Bourguignon, JJ; Chambon, JP; Heaulme, M; Perio, A; Tebib, S; Wermuth, CG | 1 |
| Lafaille, F; Lal, S; Nair, NP; Quirion, R; Suranyi-Cadotte, B | 1 |
| Alho, H; Costa, E; Mienville, JM; Santi, MR; Vaccarino, FM; Vicini, S | 1 |
| Dierke-Dzierzon, C; Ebeling, BJ; Lauven, PM; Stoeckel, H | 1 |
| Anderson, BN; Jensen, S; Kirkegaard, L | 1 |
| Bentzinger, C; Pfeiffer, J; Pirwitz, A; Tolksdorf, W | 1 |
| Lanore, JJ; Manfredi, R; Sockeel, F; Tannières, ML; Vourc'h, G | 1 |
| Cavellat, M; Dupeyron, JP; François, G; Lienhart, A; Motin, J; Richard, JP; Roquefeuil, B; Sabathié, M; Scherpereel, P; Winckler, C | 1 |
| Dodgson, MS; Emhjellen, S; Skeie, B; Steen, PA; Wickstrøm, E | 1 |
| Camu, F; Claeys, MA; Gepts, E; Schneider, I | 1 |
| Dick, W; Ellmauer, S; Müller, H | 1 |
| Freuchen, I; Krogh, B; Mikkelsen, BO; Nielsen, JL; Riishede, L | 1 |
| Comar, D; Maziere, M; Turner, JH | 1 |
| Conti-Tronconi, B; Costa, E; Ferrero, P; Guidotti, A; Santi, MR | 1 |
| Doenicke, A; Dorow, R; Duka, T; Klotz, U | 1 |
| Herblin, WF; Mechem, CC | 1 |
| Barone, D; Colombo, G; Glasser, A; Luzzani, F; Mennini, T | 1 |
| Caputti, E; Cardinali, DP; Lowenstein, PR; Rosenstein, R | 1 |
| Möhler, H | 1 |
| Chiu, TH; Rosenberg, HC | 2 |
| Comar, D; Crouzel, M; Guibert, B; Hantraye, P; Kaïsima, M; Mazière, M; Naquet, R; Prenant, C; Sastre, J | 1 |
| Borea, PA; Karobath, M; Supavilai, P | 1 |
| Goldberg, ME; Malick, JB; Patel, JB; Salama, AI | 1 |
| Bernard, P; Cassidy, JP; Czernik, AJ; Petrack, B; Yokoyama, N | 1 |
| Colombo, G; Glässer, A; Luzzani, F | 1 |
| Burkard, WP; Haefely, W; Keller, HH; Möhler, H; Richards, JG | 1 |
| De Robertis, E; Medina, JH; Novas, ML | 2 |
| Lichtensteiger, W; Möhler, H; Richards, JG; Schlumpf, M | 1 |
| Gee, KW; Yamamura, HI | 1 |
| Cooper, EC; Diamond, I; Gordon, A; Greenberg, DA | 1 |
| Brown, CL; Martin, IL | 1 |
| Garattini, S; Mennini, T | 1 |
| Cepeda, C; Comar, D; Crouzel, M; Guibert, B; Hantraye, P; Kaijima, M; Maziere, M; Naquet, R; Prenant, C; Sastre, J | 1 |
| Jeevanjee, F; Johnson, AM; Loudon, JM; Nicholass, JM | 1 |
| Hirsch, JD | 1 |
| Jing, X; Sloan, JW; Wala, EP | 2 |
| Niles, LP; Tenn, CC | 1 |
| Jenck, F; Martin, JR; Moreau, JL | 1 |
| Adachi, M; Akatsu, M; Okuaki, A; Sinoda, M; Tase, C; Terashima, M; Watanabe, K | 1 |
| Albin, RL; Burdette, DE; Frey, KA; Henry, TR; Pennell, PB; Ross, DA; Sackellares, JC; Sakurai, SY | 1 |
| Kapetanovic, IM; Kupferberg, HJ; Torchin, CD | 1 |
| Fuchs, K; Mossier, B; Sieghart, W; Tögel, M | 1 |
| Bannwarth, W; Benke, D; Fritschy, JM; Mohler, H; Trzeciak, A | 1 |
| Hu, XJ; Ticku, MK | 1 |
| Harris, RA; Klein, RL; McQuilkin, SJ; Sanna, E; Whiting, PJ | 1 |
| Harris, RA; Klein, RL; Whiting, PJ | 1 |
| Ruggieri, MR; Smyth, RJ; Uhlman, EJ | 1 |
| Harris, RA; McQuilkin, SJ; Mihic, SJ; Whatley, VJ | 1 |
| Beauchemin, V; Dennis, T; Lavoie, N | 1 |
| Airaksinen, MM; Nieminen, SA; Railoma, O; Titievsky, AV | 1 |
| Chimirri, A; DeSarro, A; DeSarro, GB; Grasso, S; Zappalà, M | 1 |
| Davies, MF; Loew, GH; Maguire, PA | 1 |
| Kanayama, T; Koshikawa, N; Murai, T; Takada, K | 1 |
| Hadingham, KL; Palmer, KJ; Thompson, SA; Wafford, KA; Whiting, PJ | 1 |
| Karle, J; Nielsen, M | 1 |
| Mehta, AK; Shank, RP | 1 |
| Atsmon, J; Dagan, Y; Gavish, M; Laschiner, S; Laudon, M; Oaknin, S; Zisapel, N | 1 |
| Jun, X; Katsura, M; Kuriyama, K; Ohkuma, S | 1 |
| Hatta, S; Saito, T; Takahata, N; Toki, S | 1 |
| Davies, PA; Hales, TG; Hanna, MC; Kirkness, EF | 1 |
| Bowery, BJ; Dawson, GR; Easter, A; Seabrook, GR | 1 |
| Thompson, SA; Wafford, KA; Whiting, PJ; Wingrove, PB | 1 |
| Schechter, MD | 1 |
| Atack, JR; McKernan, RM; Smith, AJ | 1 |
| Chiu, TH; Li, M; Rosenberg, HC; Walsh, LA; Zhao, TJ | 1 |
| Hosoi, R; Inoue, O; Kobayashi, K; Watanabe, Y | 1 |
| Davies, M; Dunn, SM; Lambert, JJ; Muntoni, AL | 1 |
| Bruni, F; Ciciani, G; Costa, B; Costanzo, A; Gratteri, P; Guerrini, G; Lucacchini, A; Martini, C; Selleri, S | 1 |
| Boileau, AJ; Czajkowski, C; Kucken, AM; Teissére, JA; Wagner, DA; Ward, PR | 1 |
| Bey, T; Brammer, G; Gibly, R; Kohler, S; Torres, R; Walter, FG | 1 |
| Li, M; Rosenberg, HC; Szabo, A | 1 |
| Betti, L; Bistocchi, M; Giannaccini, G; Gori, M; Lucacchini, A | 1 |
| Bromidge, FA; Casula, MA; Hadingham, KL; Martin, K; Maubach, K; Pillai, GV; Seabrook, GR; Whiting, PJ; Wingrove, PB | 1 |
| Gauzit, R; Morazin, F; Pham-Tourreau, S; Pourriat, JL; Teboul, A | 1 |
| Cho, J; Choi, HC; Ha, JH; Kang, BS; Lee, DU; Lee, KY; Lim, JC | 1 |
| Safo, P; Thompson, SA; Wafford, KA; Wheat, L; Whiting, PJ; Wingrove, PB | 1 |
| Ahboucha, S; Butterworth, RF; Chatauret, N; Desjardins, P; Pomier-Layrargues, G | 1 |
| Jembrek, MJ; Lazić, J; Pericić, D; Rajcan, I; Strac, DS | 1 |
| Inoue, T; Kamei, C; Masuoka, T; Ohmori, A; Shinomiya, K; Tokunaga, S; Utsu, Y | 1 |
| Bernöster, K; Dost, R; Egerland, U; Langen, B; Rundfeldt, C; Unverferth, K | 1 |
| Ahboucha, S; Araqi, F; Butterworth, RF; Layrargues, GP | 1 |
| Baur, R; Senn, M; Séquin, U; Sigel, E; Simmen, U | 1 |
| Jembrek, MJ; Pericić, D; Strac, DS; Vlainić, J | 1 |
| Atack, JR; Cook, SM; Guiblin, A; McKernan, RM; Moyes, C; Pike, A; Pym, LJ; Rosahl, TW; Scott-Stevens, P; Sohal, B; Watt, AP | 1 |
| Jazvinsćak Jembrek, M; Pericić, D; Svob Strac, D; Vlainić, J | 1 |
| Betts, BA; Gill, N; Griffith, TN; Hall, AC; Humbert, DJ; Jenkins, A; Kelly, EW; Kotey, FO; Rowan, KC; Veneskey, KC; Watt, EE | 1 |
| Furtmueller, B; Furtmueller, R; Huck, S; Marder, M; Paladini, AC; Ramerstorfer, J; Sieghart, W; Wasowski, C | 1 |
| Bostwick, R; Chen, T; Huston, J; Knappenberger, K; Liu, J; Norris, T; Wood, M | 1 |
| Douglas, SA; Furukawa, K; Hashiba, E; Hirota, K; Kawaguchi, Y; Kudo, M; Kudo, T; Kushikata, T; Ono, T; Yoshida, H | 1 |
| Baer, K; Faull, RL; Waldvogel, HJ | 1 |
| Abe, K; Hosoi, R; Inoue, O; Momosaki, S | 1 |
| Bai, X; Gerak, LR | 1 |
| France, CP; Gerak, LR | 2 |
| Benkherouf, AY; Kortesniemi, M; Laaksonen, O; Logrén, N; Salo-Ahen, OMH; Soini, SL; Somborac, T; Uusi-Oukari, M; Yang, B | 1 |
4 review(s) available for flumazenil and flunitrazepam
| Article | Year |
|---|---|
Flumazenil for post-operative recovery after general anaesthesia.
Topics: Anesthesia, General; Double-Blind Method; Flumazenil; Flunitrazepam; Humans; Midazolam; Postoperative Care; Random Allocation; Receptors, GABA-A | 1988 |
Clinical pharmacology of flumazenil.
Topics: Animals; Flumazenil; Flunitrazepam; Humans; Mathematics; Midazolam; Receptors, GABA-A; Sleep | 1988 |
Benzodiazepine receptors resolved.
Topics: Animals; Antibodies, Monoclonal; Autoradiography; Benzodiazepines; Benzodiazepinones; Bicuculline; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Chlorides; Clonazepam; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Histocytochemistry; Humans; Immunologic Techniques; Ionophores; Muscimol; Neurons; Radioisotopes; Radioligand Assay; Receptors, GABA-A; Spinal Cord; Synapses; Tissue Distribution | 1986 |
Novel non-benzodiazepine anxiolytics.
Topics: Animals; Anti-Anxiety Agents; Azabicyclo Compounds; Benzodiazepines; Benzodiazepinones; Conflict, Psychological; Flumazenil; Flunitrazepam; Hypnotics and Sedatives; Mice; Piperazines; Pyrazoles; Pyridazines; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
25 trial(s) available for flumazenil and flunitrazepam
| Article | Year |
|---|---|
Thyrotropin-releasing hormone selectively reverses lorazepam-induced sedation but not slowing of saccadic eye movements.
Topics: Adult; Conscious Sedation; Female; Flumazenil; Flunitrazepam; Humans; Injections, Intravenous; Kinetics; Lorazepam; Male; Radioligand Assay; Receptors, GABA-A; Saccades; Sleep Stages; Thyrotropin-Releasing Hormone | 1992 |
Antagonism of benzodiazepine-fentanyl anaesthesia with flumazenil.
Topics: Adult; Anesthesia, Inhalation; Anti-Anxiety Agents; Double-Blind Method; Female; Fentanyl; Flumazenil; Flunitrazepam; Humans; Male; Midazolam; Middle Aged; Preanesthetic Medication; Randomized Controlled Trials as Topic | 1990 |
[Beta activation following the intravenous administration of benzodiazepines and the specific antagonist flumazenil (Ro 15-1788)].
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Beta Rhythm; Diazepam; Dose-Response Relationship, Drug; Electroencephalography; Flumazenil; Flunitrazepam; Humans; Injections, Intravenous; Lorazepam; Male; Midazolam; Prospective Studies; Randomized Controlled Trials as Topic; Stimulation, Chemical | 1990 |
Coronary and left ventricular hemodynamic responses following reversal of flunitrazepam-induced sedation with flumazenil in patients with coronary artery disease.
Topics: Adult; Coronary Circulation; Coronary Disease; Diastole; Female; Flumazenil; Flunitrazepam; Humans; Male; Middle Aged; Oxygen Consumption; Vascular Resistance; Ventricular Function, Left | 1991 |
[Antagonism of the sedative effects of flunitrazepam used as a hypnotic agent in neuroleptanalgesia using flumazenil administered by i.v. and i.m. routes].
Topics: Adult; Double-Blind Method; Female; Flumazenil; Flunitrazepam; Humans; Injections, Intramuscular; Injections, Intravenous; Male; Middle Aged; Neuroleptanalgesia | 1991 |
Acute reversal of flunitrazepam effects by Ro 15-1788 and Ro 15-3505: inverse agonism, tolerance, and rebound.
Topics: Adult; Attention; Benzodiazepines; Benzodiazepinones; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Electroencephalography; Flumazenil; Flunitrazepam; Humans; Injections, Intravenous; Male; Psychomotor Performance; Sleep; Wakefulness | 1990 |
[Antagonism of flunitrazepam and fentanyl by flumazenil, naloxone or nalbuphine].
Topics: Adult; Double-Blind Method; Fentanyl; Flumazenil; Flunitrazepam; Humans; Middle Aged; Morphinans; Nalbuphine; Naloxone; Randomized Controlled Trials as Topic; Respiratory Insufficiency | 1990 |
Effects of flunitrazepam on memory and their reversal by two antagonists.
Topics: Adult; Benzodiazepinones; Clinical Trials as Topic; Flumazenil; Flunitrazepam; Humans; Infant, Newborn; Infusions, Intravenous; Male; Memory; Mental Recall; Psychological Tests; Retention, Psychology; Serial Learning; Sleep Stages; Verbal Learning | 1989 |
[Hemodynamic and adrenergic effects of flumazenil after general anesthesia with flunitrazepam].
Topics: Adolescent; Adult; Aged; Anesthesia Recovery Period; Anesthesia, General; Double-Blind Method; Female; Flumazenil; Flunitrazepam; Hemodynamics; Humans; Male; Middle Aged; Norepinephrine; Randomized Controlled Trials as Topic | 1989 |
[Comparative study of the antagonizing effect to flunitrazepam between Ro 15-1788 and physostigmine].
Topics: Adult; Female; Flumazenil; Flunitrazepam; Humans; Male; Middle Aged; Physostigmine | 1989 |
[Clinical evaluation of the efficacy of Ro 15-1788, Anexate after balanced intravenous anesthesia with flunitrazepam and fentanyl].
Topics: Adult; Aged; Anesthesia Recovery Period; Anesthesia, Intravenous; Clinical Trials as Topic; Drug Evaluation; Female; Fentanyl; Flumazenil; Flunitrazepam; Humans; Male; Middle Aged; Postoperative Period | 1989 |
Assessment of the efficacy and tolerance of flumazenil in reversing flunitrazepam effects on the CNS.
Topics: Adult; Anesthesia, General; Female; Flumazenil; Flunitrazepam; Hemodynamics; Humans; Male; Receptors, GABA-A | 1988 |
Changes in noradrenaline plasma levels and behavioural responses induced by benzodiazepine agonists with the benzodiazepine antagonist Ro 15-1788.
Topics: Adult; Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Blood Pressure; Double-Blind Method; Electrocardiography; Electroencephalography; Flumazenil; Flunitrazepam; Humans; Lorazepam; Male; Norepinephrine; Random Allocation | 1986 |
[Effectiveness of the benzodiazepine antagonist Ro 15-1788 following anesthesia induced by flunitrazepam].
Topics: Anesthesia, General; Arousal; Attention; Clinical Trials as Topic; Consciousness; Double-Blind Method; Flumazenil; Flunitrazepam; Humans; Random Allocation | 1986 |
Randomized clinical investigation of Ro 15-1788, a benzodiazepine antagonist, in reversing the central effects of flunitrazepam.
Topics: Adjuvants, Anesthesia; Clinical Trials as Topic; Double-Blind Method; Flumazenil; Flunitrazepam; Humans; Preanesthetic Medication; Random Allocation | 1987 |
[Ro 15-1788 antagonizes reliably the Benzodiazepine effect after Flunitrazepam combination anesthesias].
Topics: Adult; Aged; Anesthesia, General; Benzodiazepines; Blood Pressure; Cognition; Female; Flumazenil; Flunitrazepam; Humans; Injections, Intravenous; Male; Middle Aged; Postoperative Period | 1987 |
[Clinical evaluation of flumazenil (Anexate) on the recovery parameters following the administration of 3 benzodiazepines (flunitrazepam, midazolam or diazepam].
Topics: Adult; Aged; Analgesics; Anesthesia Recovery Period; Anesthesia, General; Benzodiazepines; Diazepam; Drug Evaluation; Female; Flumazenil; Flunitrazepam; Humans; Male; Midazolam; Middle Aged; Postoperative Period; Prospective Studies; Random Allocation; Respiration | 1987 |
[Evaluation of the efficacy and tolerance of flumazenil in antagonism of the effects of flunitrazepam on the central nervous system].
Topics: Adolescent; Adult; Aged; Anesthesia Recovery Period; Anesthesia, General; Central Nervous System; Clinical Trials as Topic; Female; Flumazenil; Flunitrazepam; Humans; Male; Middle Aged; Placebos | 1988 |
Antagonism of flunitrazepam-induced sedative effects by flumazenil in patients after surgery under general anaesthesia. A double-blind placebo-controlled investigation of efficacy and safety.
Topics: Adolescent; Adult; Anesthesia, General; Clinical Trials as Topic; Double-Blind Method; Female; Flumazenil; Flunitrazepam; Humans; Middle Aged; Preanesthetic Medication; Random Allocation; Surgical Procedures, Operative | 1988 |
Reversal of flunitrazepam with flumazenil: duration of antagonist activity.
Topics: Adult; Aged; Anesthesia Recovery Period; Anesthesia, Local; Double-Blind Method; Flumazenil; Flunitrazepam; Hemodynamics; Humans; Middle Aged; Random Allocation | 1988 |
[Efficacy and safety of the benzodiazepine antagonist RO 15-1788].
Topics: Adult; Anesthesia Recovery Period; Benzodiazepines; Clinical Trials as Topic; Double-Blind Method; Female; Flumazenil; Flunitrazepam; Humans; Male; Middle Aged; Postoperative Period; Prospective Studies; Random Allocation | 1988 |
Reversal of flunitrazepam sedation with flumazenil. A randomized clinical trial.
Topics: Aged; Aged, 80 and over; Anesthesia, Spinal; Awareness; Clinical Trials as Topic; Double-Blind Method; Flumazenil; Flunitrazepam; Humans; Hypnotics and Sedatives; Male; Memory; Middle Aged; Placebos; Random Allocation | 1988 |
Flunitrazepam and lormetazepam do not affect the pharmacokinetics of the benzodiazepine antagonist Ro 15-1788.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Flumazenil; Flunitrazepam; Humans; Kinetics; Lorazepam; Male | 1985 |
Effect of the benzodiazepine antagonist Ro 15-1788 on flunitrazepam-induced sleep changes.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Double-Blind Method; Female; Flumazenil; Flunitrazepam; Humans; Male; Sleep; Sleep Stages; Time Factors | 1983 |
[The effect of flumazenil in reversing midazolam, flunitrazepam or diazepam].
Topics: Adolescent; Adult; Anesthesia Recovery Period; Anesthesia, Epidural; Anesthesia, Spinal; Diazepam; Female; Flumazenil; Flunitrazepam; Hemodynamics; Humans; Male; Midazolam; Middle Aged; Respiration | 1995 |
157 other study(ies) available for flumazenil and flunitrazepam
| Article | Year |
|---|---|
Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach.
Topics: Animals; Benzodiazepines; Carbolines; Cell Line; Columbidae; Conditioning, Operant; Crystallography, X-Ray; Humans; Indoles; Ligands; Male; Models, Molecular; Pyrimidines; Quinolones; Radioligand Assay; Receptors, GABA-A; Saimiri; Stereoisomerism; Structure-Activity Relationship | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit.
Topics: Animals; Behavior, Animal; Benzodiazepines; Chemical Phenomena; Chemistry, Physical; Computer Simulation; Databases, Factual; Electrophysiology; Female; Ligands; Male; Memory; Mice; Models, Molecular; Molecular Structure; Oocytes; Protein Isoforms; Protein Subunits; Quantitative Structure-Activity Relationship; Receptors, GABA-A; Structure-Activity Relationship; Xenopus laevis | 2008 |
Ethyl 8-fluoro-6-(3-nitrophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate as novel, highly potent, and safe antianxiety agent.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Binding Sites; Brain; Cattle; Computer Simulation; Crystallography, X-Ray; gamma-Aminobutyric Acid; Humans; Hydrogen Bonding; Imidazoles; Mice; Models, Molecular; Molecular Structure; Pentylenetetrazole; Seizures; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
New insight into the central benzodiazepine receptor-ligand interactions: design, synthesis, biological evaluation, and molecular modeling of 3-substituted 6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and related compounds.
Topics: Animals; Benzodiazepines; Binding Sites; Binding, Competitive; Cattle; Cerebral Cortex; Chlorides; Flumazenil; HEK293 Cells; Humans; Ligands; Male; Mice; Models, Molecular; Molecular Structure; Motor Activity; Protein Structure, Tertiary; Protein Subunits; Radioligand Assay; Receptors, GABA-A; Synaptosomes; Tritium; Xenopus laevis | 2011 |
Synthesis and biological evaluation of 4-phenylquinazoline-2-carboxamides designed as a novel class of potent ligands of the translocator protein.
Topics: Animals; Binding, Competitive; Carrier Proteins; Cell Line, Tumor; Cell Survival; Inhibitory Concentration 50; Molecular Structure; Quinazolines; Rats; Receptors, GABA-A; Structure-Activity Relationship | 2012 |
Design, Synthesis, and Biological Evaluation of Imidazo[1,5-a]quinoline as Highly Potent Ligands of Central Benzodiazepine Receptors.
Topics: Amnesia; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Binding Sites; Brain; Cattle; Drug Design; Humans; Ischemia; Ligands; Male; Mice; Models, Molecular; Neuroprotective Agents; Quinolines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Structure-Activity Relationship; Synaptosomes | 2016 |
Regional distribution and kinetics of three sites on the GABAA receptor: lack of effect of portacaval shunting.
Topics: Animals; Autoradiography; Binding Sites; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Flumazenil; Flunitrazepam; Image Processing, Computer-Assisted; Kinetics; Male; Muscimol; Portacaval Shunt, Surgical; Rats; Rats, Inbred Strains; Receptors, GABA-A; Tissue Distribution | 1992 |
The effect of benzodiazepines on the binding of [3H]SCH 23390 in vivo.
Topics: Animals; Benzazepines; Binding, Competitive; Brain; Cerebellum; Cerebral Cortex; Corpus Striatum; Flumazenil; Flunitrazepam; Kinetics; Male; Mice; Mice, Inbred Strains; Models, Neurological; Organ Specificity; Receptors, GABA-A | 1992 |
Evidence for more than two central benzodiazepine receptors in rat spinal cord.
Topics: Animals; Binding, Competitive; Diazepam; Flumazenil; Flunitrazepam; Rats; Receptors, GABA-A; RNA, Messenger; Spinal Cord | 1992 |
Regional distribution of low-affinity GABA receptors coupled to benzodiazepine receptor subtypes in rat brain.
Topics: Animals; Autoradiography; Brain; Brain Chemistry; Flumazenil; Flunitrazepam; In Vitro Techniques; Rats; Receptors, GABA-A | 1992 |
Ligand-dependent effects of ethanol and diethylether at brain benzodiazepine receptors.
Topics: Animals; Ethanol; Ether; Flumazenil; Flunitrazepam; Ligands; Male; Membranes; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1992 |
Changes in benzodiazepine-receptor activity modify morphine withdrawal syndrome in mice.
Topics: Animals; Azides; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Flumazenil; Flunitrazepam; Male; Mice; Morphine; Receptors, GABA-A; Substance Withdrawal Syndrome | 1992 |
Comparison of behavioral and central BDZ binding profile in three rat lines.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Behavior, Animal; Binding, Competitive; Body Temperature; Eating; Flumazenil; Flunitrazepam; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, GABA-A; Species Specificity | 1992 |
Functional expression of GABAA chloride channels and benzodiazepine binding sites in baculovirus infected insect cells.
Topics: Animals; Baculoviridae; Benzodiazepinones; Binding Sites; Cell Line; Cell Membrane; Chloride Channels; DNA; Electrophysiology; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Membrane Proteins; Moths; Rats; Receptors, GABA-A; Transfection | 1992 |
Locomotor responses to benzodiazepines, barbiturates and ethanol in diazepam-sensitive (DS) and -resistant (DR) mice.
Topics: Analysis of Variance; Animals; Diazepam; Dose-Response Relationship, Drug; Ethanol; Female; Flumazenil; Flunitrazepam; Male; Mice; Motor Activity; Pentobarbital; Phenobarbital | 1992 |
Benzodiazepine receptor sites in the chick optic lobe: development and pharmacological characterization.
Topics: Animals; Binding, Competitive; Chick Embryo; Chickens; Clonazepam; Flumazenil; Flunitrazepam; Kinetics; Receptors, GABA-A; Synaptic Membranes; Tectum Mesencephali; Time Factors | 1991 |
Differential expression of GABAA receptor alpha-subunits in rat brain during development.
Topics: Animals; Animals, Newborn; Binding Sites; Blotting, Western; Brain; Flumazenil; Flunitrazepam; Radioligand Assay; Rats; Receptors, GABA-A | 1991 |
Habituation and inhibitory avoidance training alter brain regional levels of benzodiazepine-like molecules and are affected by intracerebral flumazenil microinjection.
Topics: Animals; Avoidance Learning; Benzodiazepines; Brain; Brain Chemistry; Flumazenil; Flunitrazepam; Habituation, Psychophysiologic; Male; Microinjections; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Muscarinic; Reference Values; Stereotyped Behavior | 1991 |
The effect of medetomidine on GABA and benzodiazepine receptors in vivo: lack of anxiolytic but some evidence of possible stress-protective activity.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Bicuculline; Brain; Cerebral Cortex; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Imidazoles; Kidney; Male; Medetomidine; Muscimol; Myocardium; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Stimulation, Chemical; Stress, Physiological; Tritium | 1991 |
gamma-Aminobutyric acidA receptor regulation in culture: altered allosteric interactions following prolonged exposure to benzodiazepines, barbiturates, and methylxanthines.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Allosteric Regulation; Animals; Barbital; Barbiturates; Brain; Caffeine; Cells, Cultured; Chick Embryo; Flumazenil; Flunitrazepam; Flurazepam; gamma-Aminobutyric Acid; Kinetics; Neurons; Pentobarbital; Receptors, GABA-A; Tetrodotoxin; Theophylline; Veratridine | 1990 |
[Sedation with flunitrazepam and its antagonism with flumazenil in endoscopic urological procedures: our clinical experience].
Topics: Adult; Aged; Blood Pressure; Conscious Sedation; Consciousness; Cystoscopy; Female; Flumazenil; Flunitrazepam; Humans; Hypnotics and Sedatives; Male; Middle Aged; Urinary Bladder Neoplasms | 1991 |
A comparison of the physical dependence inducing properties of flunitrazepam and diazepam.
Topics: Animals; Biotransformation; Blood Proteins; Brain Chemistry; Diazepam; Dogs; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; Protein Binding; Seizures; Substance Withdrawal Syndrome; Substance-Related Disorders | 1991 |
Relative efficacies of benzodiazepine receptor agonists in affecting red nucleus electrical activity in rabbits.
Topics: Animals; Bicuculline; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; Imidazoles; Isoquinolines; Male; Pentylenetetrazole; Pyridazines; Pyridines; Rabbits; Receptors, GABA-A; Red Nucleus; Zolpidem | 1990 |
Benzodiazepine agonist and inverse agonist actions on GABAA receptor-operated chloride channels. I. Acute effects of ethanol.
Topics: Animals; Benzodiazepines; Brain; Carbolines; Chloride Channels; Chlorides; Convulsants; Ethanol; Flumazenil; Flunitrazepam; Injections, Intraperitoneal; Male; Membrane Proteins; Mice; Mice, Inbred ICR; Tritium | 1990 |
Flunitrazepam photoaffinity labeling of the GABA(A) receptor reduces inhibition of [3H]Ro15-4513 binding by GABA.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Brain; Chick Embryo; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Membranes; Photochemistry; Receptors, GABA-A | 1990 |
Chronic benzodiazepine antagonist treatment and its withdrawal upregulates components of GABA-benzodiazepine receptor ionophore complex in cerebral cortex of rat.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Convulsants; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, GABA-A; Reference Values; Up-Regulation | 1990 |
The activity of zolpidem and other hypnotics within the gamma-aminobutyric acid (GABAA) receptor supramolecular complex, as determined by 35S-t-butylbicyclophosphorothionate (35S-TBPS) binding to rat cerebral cortex membranes.
Topics: Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Hypnotics and Sedatives; In Vitro Techniques; Male; Pyridines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Zolpidem | 1990 |
[A benzodiazepine antagonist flumazenil in clinical use--a dose finding study].
Topics: Adolescent; Adult; Aged; Anesthesia Recovery Period; Female; Flumazenil; Flunitrazepam; Humans; Male; Middle Aged | 1990 |
Stress-induced changes in t-[35S]butylbicyclophosphorothionate binding to gamma-aminobutyric acid-gated chloride channels are mimicked by in vitro occupation of benzodiazepine receptors.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cerebral Cortex; Chlorides; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Ion Channels; Kinetics; Male; Membranes; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stress, Physiological; Swimming | 1987 |
Chronic benzodiazepine administration. II. Discontinuation syndrome is associated with upregulation of gamma-aminobutyric acidA receptor complex binding and function.
Topics: Animals; Binding Sites; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chlorides; Drug Tolerance; Flumazenil; Flunitrazepam; Ion Channels; Lorazepam; Male; Mice; Motor Activity; Muscimol; Receptors, GABA-A; Time Factors | 1988 |
Chloride channel modulation through the benzodiazepine recognition site.
Topics: Animals; Bicuculline; Carbolines; Cells, Cultured; Chlorides; Convulsants; Flumazenil; Flunitrazepam; Ion Channels; Neurons; Receptors, GABA-A | 1988 |
Differential effects of flunitrazepam on human sleep in combination with flumazenil.
Topics: Adult; Electroencephalography; Female; Flumazenil; Flunitrazepam; Humans; Male; Receptors, Drug; Sleep; Sleep Stages; Sleep, REM; Wakefulness | 1989 |
Flunitrazepam intoxication in a child successfully treated with the benzodiazepine antagonist flumazenil.
Topics: Flumazenil; Flunitrazepam; Humans; Infant; Male | 1989 |
[The effect of flumazenil on post-operative oxygen consumption in normothermic and hypothermic patients].
Topics: Female; Fentanyl; Flumazenil; Flunitrazepam; Humans; Hypothermia, Induced; Male; Middle Aged; Oxygen Consumption; Postoperative Period | 1989 |
Chronic exposure to Ro 15-1788: differential effect on flunitrazepam binding to cortex and hippocampus.
Topics: Animals; Cerebral Cortex; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Kinetics; Male; Membranes; Rats; Rats, Inbred Strains; Synaptosomes | 1989 |
Benzodiazepines and the mammalian retina. I. Autoradiographic localisation of receptor sites and the lack of effect on the electroretinogram.
Topics: Animals; Benzodiazepines; Body Weight; Cats; Flumazenil; Flunitrazepam; Flurazepam; Membrane Potentials; Midazolam; Photic Stimulation; Rats; Receptors, GABA-A; Retina | 1989 |
The relationship of benzodiazepine binding sites to the norepinephrine projection in the hypothalamus of the adult rat.
Topics: Animals; Diazepam; Flumazenil; Flunitrazepam; Hypothalamus; Norepinephrine; Rats; Receptors, GABA-A | 1989 |
Type I and type II GABAA-benzodiazepine receptors produced in transfected cells.
Topics: Cell Line; Diazepam; Flumazenil; Flunitrazepam; Humans; Molecular Weight; Pyridazines; Receptors, GABA-A; Recombinant Proteins; Transfection | 1989 |
Chronic ethanol treatment selectively increases the binding of inverse agonists for benzodiazepine binding sites in cultured spinal cord neurons.
Topics: Alcoholism; Animals; Azides; Benzodiazepines; Cells, Cultured; Female; Flumazenil; Flunitrazepam; Male; Mice; Mice, Inbred C57BL; Neurons; Receptors, GABA-A; Spinal Cord | 1989 |
First use of a beta-carboline as photoaffinity label for the benzodiazepine receptor.
Topics: Affinity Labels; Animals; Carbolines; Flumazenil; Flunitrazepam; In Vitro Techniques; Kinetics; Male; Photochemistry; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1989 |
Amoxapine inhibition of GABA-stimulated chloride conductance: investigations of potential sites of activity.
Topics: Amoxapine; Animals; Cerebral Cortex; Chlorides; Dibenzoxazepines; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; GABA Antagonists; Ligands; Male; Pyridazines; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1989 |
Relative efficacies of 1,4-diazepines on GABA-stimulated chloride influx in rat brain vesicles.
Topics: Animals; Anti-Anxiety Agents; Azepines; Cell Membrane; Cerebral Cortex; Chlorides; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1989 |
Heterogeneity of gamma-aminobutyric acid/benzodiazepine/beta-carboline receptor complex in rat spinal cord.
Topics: Animals; Bicuculline; Binding, Competitive; Carbolines; Cerebellum; Diazepam; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Male; Muscimol; Rats; Receptors, GABA-A; Spinal Cord; Synaptic Membranes | 1988 |
Osmotic shock: a method to eliminate endogenous gamma-aminobutyric acid and account for the influence on benzodiazepine binding affinity in autoradiographic studies.
Topics: Animals; Autoradiography; Benzodiazepines; Bicuculline; Binding Sites; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Male; Osmotic Pressure; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1988 |
In vivo interaction of zolpidem with central benzodiazepine (BZD) binding sites (as labeled by [3H]Ro 15-1788) in the mouse brain. Preferential affinity of zolpidem for the omega 1 (BZD1) subtype.
Topics: Animals; Autoradiography; Binding Sites; Brain; Flumazenil; Flunitrazepam; Hypnotics and Sedatives; In Vitro Techniques; Male; Mice; Pyridazines; Pyridines; Receptors, GABA-A; Zolpidem | 1988 |
Drug interactions and clinical pharmacokinetics of flumazenil.
Topics: Anti-Anxiety Agents; Benzodiazepines; Biological Availability; Drug Interactions; Ethanol; Flumazenil; Flunitrazepam; Half-Life; Humans; Liver; Lorazepam; Midazolam; Receptors, GABA-A; Tomography, Emission-Computed | 1988 |
Benzodiazepine interactions with GABAA receptors on chick ciliary ganglion neurons.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Cell Membrane; Cells, Cultured; Chick Embryo; Flumazenil; Flunitrazepam; Ganglia, Parasympathetic; Membrane Potentials; Receptors, GABA-A; Spinal Cord | 1988 |
Further characterization of benzodiazepine receptor differences in long-sleep and short-sleep mice.
Topics: Animals; Cerebellum; Cerebral Cortex; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Hot Temperature; In Vitro Techniques; Kinetics; Mice; Mice, Mutant Strains; Protein Conformation; Receptors, GABA-A; Sleep | 1988 |
In vivo binding of (3H)Ro 15-1788 in mice: comparison with the in vivo binding of (3H)flunitrazepam.
Topics: Animals; Brain; Cerebellum; Cerebral Cortex; Diazepam; Flumazenil; Flunitrazepam; Hippocampus; Male; Mice; Receptors, GABA-A | 1988 |
Chronic administration of diazepam downregulates adenosine receptors in the rat brain.
Topics: Animals; Brain; Diazepam; Flumazenil; Flunitrazepam; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Purinergic | 1988 |
The interaction of substituted benzamides with brain benzodiazepine binding sites in vitro.
Topics: Affinity Labels; Animals; Benzamides; Binding, Competitive; Brain Chemistry; Cattle; Cell Membrane; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Photochemistry; Receptors, GABA-A | 1988 |
Animal models of chronic anxiety and "fearlessness".
Topics: Animals; Anxiety; Brain; Cats; Diazepam; Disease Models, Animal; Fear; Female; Flumazenil; Flunitrazepam; Male; Pregnancy; Prenatal Exposure Delayed Effects; Receptors, GABA-A | 1988 |
Differential responsiveness of cerebellar Purkinje neurons to GABA and benzodiazepine receptor ligands in an animal model of hepatic encephalopathy.
Topics: Animals; Benzodiazepines; Flumazenil; Flunitrazepam; GABA Antagonists; Galactosamine; Hepatic Encephalopathy; Ligands; Male; Muscimol; Purkinje Cells; Rabbits; Receptors, GABA-A | 1988 |
Benzodiazepine antagonist Ro 15-1788 in self-poisoning. Diagnostic and therapeutic use.
Topics: Adult; Aged; Anti-Anxiety Agents; Antidotes; Benzodiazepinones; Coma; Diazepam; Electroencephalography; Female; Flumazenil; Flunitrazepam; Humans; Male; Middle Aged; Naloxone; Suicide, Attempted | 1985 |
Benzodiazepine inhibition of [3H]flunitrazepam binding and caffeine-induced seizures in mice.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Binding, Competitive; Caffeine; Flumazenil; Flunitrazepam; Male; Mice; Receptors, GABA-A; Seizures | 1986 |
Behavioral studies with anxiolytic drugs. III. Antipunishment actions of buspirone in the pigeon do not involve benzodiazepine receptor mechanisms.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Buspirone; Chlordiazepoxide; Columbidae; Diazepam; Flumazenil; Flunitrazepam; Punishment; Pyrimidines; Receptors, GABA-A | 1986 |
[3H]Ro 15-1788 binding to benzodiazepine receptors in mouse brain in vivo: marked enhancement by GABA agonists and other CNS drugs.
Topics: Animals; Antipsychotic Agents; Barbiturates; Brain; Buspirone; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Injections, Intravenous; Male; Mice; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Vasodilator Agents | 1987 |
Functional coupling of gamma-aminobutyric acid (GABA)A and benzodiazepine type II receptors: analysis using purified GABA/benzodiazepine receptor complex from bovine cerebral cortex.
Topics: Animals; Antipsychotic Agents; Bicuculline; Cattle; Cerebral Cortex; Flumazenil; Flunitrazepam; In Vitro Techniques; Kinetics; Muscimol; Pyridazines; Receptors, GABA-A | 1987 |
Modulation of GABA-stimulated chloride influx into membrane vesicles from rat cerebral cortex by benzodiazepines and nonbenzodiazepines.
Topics: Animals; Anti-Anxiety Agents; Cell Membrane; Cerebral Cortex; Chlorides; Clonazepam; Diazepam; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Rats; Rats, Inbred Strains | 1988 |
Effects of guanyl nucleotides on [3H]flunitrazepam binding to rat hippocampal synaptic membranes: equilibrium binding and dissociation kinetics.
Topics: Adenosine Triphosphate; Animals; Benzodiazepinones; Diazepam; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Guanine Nucleotides; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Hippocampus; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptic Membranes | 1985 |
Central effects of nicotinamide and inosine which are not mediated through benzodiazepine receptors.
Topics: Action Potentials; Animals; Benzodiazepinones; Bicuculline; Binding, Competitive; Brain; Chlordiazepoxide; Convulsants; Female; Flumazenil; Flunitrazepam; In Vitro Techniques; Inosine; Male; Membranes; Niacinamide; Purkinje Cells; Rats; Rats, Inbred Strains; Receptors, GABA-A; Social Behavior | 1985 |
Radiation inactivation studies of the benzodiazepine/gamma-aminobutyric acid/chloride ionophore receptor complex.
Topics: Animals; Barbiturates; Benzodiazepines; Benzodiazepinones; Binding Sites; Brain; Carbolines; Cell Membrane; Chlorides; Diazepam; Flumazenil; Flunitrazepam; Ionophores; Male; Molecular Weight; Muscimol; Picrotoxin; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1985 |
Benzodiazepine receptor binding in vivo with [3H]-Ro 15-1788.
Topics: Animals; Autoradiography; Benzodiazepinones; Brain; Clonazepam; Flumazenil; Flunitrazepam; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Receptors, GABA-A; Time Factors; Tritium | 1985 |
Photoaffinity labelling of benzodiazepine receptors: lack of effect on ligand binding to the nucleoside transport system.
Topics: Affinity Labels; Animals; Benzodiazepinones; Biological Transport, Active; Carbolines; Cerebral Cortex; Dipyridamole; Flumazenil; Flunitrazepam; Guinea Pigs; Nucleosides; Photochemistry; Receptors, GABA-A; Thioinosine | 1985 |
Monoclonal antibodies to benzodiazepines.
Topics: Animals; Anti-Anxiety Agents; Antibodies, Monoclonal; Benzodiazepines; Benzodiazepinones; Diazepam; Flumazenil; Flunitrazepam; Flurazepam; Mice; Mice, Inbred BALB C; Receptors, GABA-A; Structure-Activity Relationship | 1985 |
Differential sensitivity of "central" and "peripheral" type benzodiazepine receptors to phospholipase A2.
Topics: Animals; Benzodiazepinones; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Cerebral Cortex; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Kidney; Male; Myocardium; Pentobarbital; Phospholipases; Phospholipases A; Phospholipases A2; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1986 |
Regional difference in brain benzodiazepine receptor carbohydrates.
Topics: Acetylglucosaminidase; Animals; Asparagine; Benzodiazepinones; Brain Chemistry; Carbohydrates; Electrophoresis, Polyacrylamide Gel; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Male; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Molecular Weight; Muscimol; Neuraminidase; Pentobarbital; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sialic Acids; Tritium | 1986 |
Ro 15-1788 suppresses the development of kindling through the benzodiazepine receptor.
Topics: Animals; Cerebral Cortex; Flumazenil; Flunitrazepam; GABA-A Receptor Antagonists; Hippocampus; Kindling, Neurologic; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1986 |
A 7-phenyl substituted triazolopyridazine has inverse agonist activity at the benzodiazepine receptor site.
Topics: Animals; Binding, Competitive; Brain; Conditioning, Operant; Convulsants; Diazepam; Female; Flumazenil; Flunitrazepam; In Vitro Techniques; Male; Mice; Pyridazines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Structure-Activity Relationship | 1987 |
Coexistence of central and peripheral benzodiazepine binding sites in the human pineal gland.
Topics: Aged; Benzodiazepinones; Binding, Competitive; Cell Membrane; Clonazepam; Female; Flumazenil; Flunitrazepam; Humans; Isoquinolines; Male; Middle Aged; Pineal Gland; Receptors, GABA-A | 1987 |
Modulation of gamma-aminobutyric acid-mediated inhibitory synaptic currents in dissociated cortical cell cultures.
Topics: Animals; Bicuculline; Carbolines; Cells, Cultured; Cerebral Cortex; Electric Conductivity; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Membrane Potentials; Neural Inhibition; Rats; Synapses | 1986 |
Localization of 11C-radiopharmaceuticals in the Greene melanoma of hamsters.
Topics: Animals; Benzodiazepinones; Carbon Radioisotopes; Chlorpromazine; Cricetinae; Flumazenil; Flunitrazepam; Gallium Radioisotopes; Isotope Labeling; Ketanserin; Melanoma; Mesocricetus; Methionine; Neoplasm Transplantation; Pimozide; Piperidines; Quinuclidinyl Benzilate; Radionuclide Imaging; Tissue Distribution | 1985 |
Study of an octadecaneuropeptide derived from diazepam binding inhibitor (DBI): biological activity and presence in rat brain.
Topics: Amino Acid Sequence; Animals; Behavior, Animal; Benzodiazepinones; Brain Chemistry; Carbolines; Chromatography, High Pressure Liquid; Diazepam Binding Inhibitor; Enzyme-Linked Immunosorbent Assay; Flumazenil; Flunitrazepam; Male; Nerve Tissue Proteins; Neuropeptides; Peptide Fragments; Rats; Rats, Inbred Strains; Seizures; Synaptic Membranes | 1986 |
Short-wave ultraviolet irradiation increases photo-affinity labeling of benzodiazepine sites.
Topics: Affinity Labels; Animals; Benzodiazepinones; Binding Sites; Cell Membrane; Cerebellum; Cerebral Cortex; Clonazepam; Flumazenil; Flunitrazepam; In Vitro Techniques; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Ultraviolet Rays | 1984 |
In vitro interaction of premazepam with benzodiazepine receptors in rat brain regions.
Topics: Animals; Azepines; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Brain; Cerebellum; Convulsants; Diazepam; Flumazenil; Flunitrazepam; Kinetics; Male; Organ Specificity; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Synaptosomes; Thermodynamics | 1984 |
Benzodiazepine binding sites in human pineal gland.
Topics: Adolescent; Adult; Aged; Animals; Benzodiazepinones; Binding, Competitive; Cerebral Cortex; Child; Child, Preschool; Clonazepam; Diazepam; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Humans; In Vitro Techniques; Infant; Kinetics; Male; Middle Aged; Pineal Gland; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1984 |
Benzodiazepine receptors: differential interaction of benzodiazepine agonists and antagonists after photoaffinity labeling with flunitrazepam.
Topics: Affinity Labels; Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Flumazenil; Flunitrazepam; Protein Conformation; Rats; Receptors, Drug; Receptors, GABA-A | 1982 |
Comparison of the kinetics of [3H]diazepam and [3H]flunitrazepam binding to cortical synaptosomal membranes.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Cerebral Cortex; Diazepam; Filtration; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Male; Pentobarbital; Rats; Rats, Inbred Strains; Sodium Chloride; Synaptic Membranes | 1982 |
[11C-Ro15-1788 and 11C-flunitrazepam, two coordinates for the study by positron emission tomography of benzodiazepine binding sites].
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Brain; Flumazenil; Flunitrazepam; Kinetics; Papio; Receptors, Cell Surface; Receptors, GABA-A; Tomography, Emission-Computed | 1983 |
Differential modulation of etazolate or pentobarbital enhanced [3H] muscimol binding by benzodiazepine agonists and inverse agonists.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Carbolines; Cell Membrane; Cerebral Cortex; Convulsants; Etazolate; Flumazenil; Flunitrazepam; Kinetics; Muscimol; Nicotinic Acids; Oxazoles; Pentobarbital; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Benzodiazepine receptor ligands with opposing pharmacologic actions.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Diazepam; Flumazenil; Flunitrazepam; Kinetics; Ligands; Membranes; Models, Psychological; Pyrazoles; Rats; Receptors, Cell Surface; Receptors, GABA-A; Temperature | 1983 |
Central benzodiazepine receptors in the spinal cord and other regions of the CNS of the cat.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Binding, Competitive; Cats; Central Nervous System; Cerebellum; Cerebral Cortex; Female; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Male; Receptors, GABA-A; Spinal Cord | 1984 |
Benzodiazepine antagonist Ro 15-1788: binding characteristics and interaction with drug-induced changes in dopamine turnover and cerebellar cGMP levels.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Brain; Cerebellum; Cerebral Cortex; Cyclic GMP; Diazepam; Dopamine; Flumazenil; Flunitrazepam; Kinetics; Mice; Receptors, Drug; Receptors, GABA-A | 1981 |
Conformational changes in benzodiazepine receptors induced by the antagonist Ro 15-1788.
Topics: Animals; Benzodiazepinones; Binding, Competitive; Cerebral Cortex; Flumazenil; Flunitrazepam; Kinetics; Male; Protein Conformation; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Synaptic Membranes; Time Factors | 1983 |
Chronic RO 15-1788 treatment increases the number of benzodiazepine receptors in rat cerebral cortex and hippocampus.
Topics: Animals; Benzodiazepinones; Carbolines; Cerebral Cortex; Female; Flumazenil; Flunitrazepam; Hippocampus; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Ontogeny of benzodiazepine binding sites in fetal rat brain: an in vitro autoradiographic study.
Topics: Animals; Autoradiography; Benzodiazepinones; Binding Sites; Brain; Flumazenil; Flunitrazepam; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Photoaffinity labeling of benzodiazepine receptors in rat brain with flunitrazepam alters the affinity of benzodiazepine receptor agonist but not antagonist binding.
Topics: Affinity Labels; Animals; Benzodiazepines; Benzodiazepinones; Brain; Carbolines; Flumazenil; Flunitrazepam; Male; Photochemistry; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Substrate Specificity | 1983 |
Ethanol and the gamma-aminobutyric acid-benzodiazepine receptor complex.
Topics: Animals; Benzodiazepinones; Brain; Carbolines; Ethanol; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Male; Membranes; Muscimol; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Temperature | 1984 |
Kinetics of [3H]Ro 15-1788 binding to membrane-bound rat brain benzodiazepine receptors.
Topics: Animals; Benzodiazepinones; Brain; Cell Membrane; Cerebellum; Convulsants; Flumazenil; Flunitrazepam; Hippocampus; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1984 |
Benzodiazepines receptor binding in vivo: pharmacokinetic and pharmacological significance.
Topics: Adrenal Glands; Animals; Benzodiazepinones; Brain; Carbolines; Corticosterone; Diazepam; Flumazenil; Flunitrazepam; Kinetics; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
[In vivo study of benzodiazepine receptors using positron emission tomography].
Topics: Animals; Benzodiazepinones; Binding, Competitive; Brain; Chlordiazepoxide; Flumazenil; Flunitrazepam; Kinetics; Lorazepam; Male; Papio; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Neurotransmitter; Stereoisomerism | 1983 |
Changes in benzodiazepine receptors by acute stress: different effect of chronic diazepam or RO 15-1788 treatment.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Cerebral Cortex; Diazepam; Female; Flumazenil; Flunitrazepam; Hippocampus; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Neurotransmitter; Stress, Physiological | 1983 |
Enhancement of [3H]flunitrazepam binding by mianserin, in vivo.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Chlordiazepoxide; Convulsants; Dibenzazepines; Drinking Behavior; Flumazenil; Flunitrazepam; Kinetics; Male; Mianserin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1984 |
Peripheral and central-type benzodiazepine binding sites in mammalian ocular tissues.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Binding Sites; Eye; Female; Flumazenil; Flunitrazepam; Macaca mulatta; Male; Rabbits; Rats; Rats, Inbred Strains | 1984 |
Flunitrazepam and nordiazepam slowly released from silastic capsules induce physical dependence in rat.
Topics: Animals; Anti-Anxiety Agents; Antidotes; Biological Availability; Delayed-Action Preparations; Diazepam; Drug Implants; Female; Flumazenil; Flunitrazepam; Nordazepam; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Substance-Related Disorders | 1995 |
Central-type benzodiazepine receptors mediate the antidopaminergic effect of clonazepam and melatonin in 6-hydroxydopamine lesioned rats: involvement of a GABAergic mechanism.
Topics: Animals; Apomorphine; Behavior, Animal; Bicuculline; Clonazepam; Corpus Striatum; Dopamine Agonists; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Isoquinolines; Male; Melatonin; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1995 |
Precipitated withdrawal in squirrel monkeys after repeated daily oral administration of alprazolam, diazepam, flunitrazepam or oxazepam.
Topics: Administration, Oral; Alprazolam; Animals; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Drug Tolerance; Female; Flumazenil; Flunitrazepam; Male; Muscle Relaxation; Oxazepam; Saimiri; Sleep; Substance Withdrawal Syndrome; Substance-Related Disorders; Tremor | 1995 |
Temporal lobe central benzodiazepine binding in unilateral mesial temporal lobe epilepsy.
Topics: Adult; Analysis of Variance; Autoradiography; Epilepsy, Temporal Lobe; Female; Flumazenil; Flunitrazepam; Functional Laterality; Humans; Male; Radioligand Assay; Receptors, GABA-A; Temporal Lobe | 1995 |
A system for testing the development and reversal of anticonvulsant tolerance to benzodiazepines in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Carbolines; Diazepam; Drug Tolerance; Flumazenil; Flunitrazepam; Infusion Pumps, Implantable; Infusions, Parenteral; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Seizures; Solvents; Time Factors | 1993 |
Immunoaffinity purification of gamma-aminobutyric acidA (GABAA) receptors containing gamma 1-subunits. Evidence for the presence of a single type of gamma-subunit in GABAA receptors.
Topics: Animals; Antibody Specificity; Base Sequence; Blotting, Western; Brain Chemistry; Chromatography, Affinity; Clonazepam; Enzyme-Linked Immunosorbent Assay; Flumazenil; Flunitrazepam; Immunologic Techniques; Molecular Sequence Data; Molecular Weight; Muscimol; Peptide Fragments; Protein Conformation; Rats; Receptors, GABA-A; Recombinant Fusion Proteins | 1994 |
Distribution, prevalence, and drug binding profile of gamma-aminobutyric acid type A receptor subtypes differing in the beta-subunit variant.
Topics: Animals; Brain Chemistry; Carbolines; Flumazenil; Flunitrazepam; Genetic Variation; Immunohistochemistry; Male; Microscopy, Confocal; Molecular Weight; Precipitin Tests; Protein Conformation; Pyridazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Tissue Distribution; Zolpidem | 1994 |
Development pattern of the GABAA-benzodiazepine receptor ionophore complex in primary cultures of cortical neurons.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Cells, Cultured; Cerebral Cortex; Chlorides; Flumazenil; Flunitrazepam; Mice; Mice, Inbred C57BL; Muscimol; Neurons; Receptors, GABA-A | 1994 |
Effects of 5-HT3 receptor antagonists on binding and function of mouse and human GABAA receptors.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Flumazenil; Flunitrazepam; Humans; Indazoles; Indoles; Male; Mice; Mice, Inbred ICR; Receptors, GABA-A; Serotonin Antagonists; Tropanes; Tropisetron; Xenopus laevis | 1994 |
Benzodiazepine treatment causes uncoupling of recombinant GABAA receptors expressed in stably transfected cells.
Topics: Allosteric Site; Animals; Benzodiazepines; Cattle; Cell Line; Clonazepam; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Mice; Receptors, GABA; Recombinant Proteins; Transfection | 1994 |
Identification and characterization of a high-affinity peripheral-type benzodiazepine receptor in rabbit urinary bladder.
Topics: Animals; Flumazenil; Flunitrazepam; GABA-A Receptor Antagonists; Isoquinolines; Male; Muscle Contraction; Muscle, Smooth; Rabbits; Receptors, GABA-A; Urinary Bladder | 1994 |
beta-Lumicolchicine interacts with the benzodiazepine binding site to potentiate GABAA receptor-mediated currents.
Topics: Animals; Benzodiazepines; Binding Sites; Binding, Competitive; Cerebral Cortex; Chlorides; DNA, Complementary; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Kinetics; Lumicolchicines; Mice; Mice, Inbred ICR; Oocytes; Receptors, GABA-A; Xenopus laevis | 1994 |
Quantitative autoradiographic studies of the effects of bilateral olfactory bulbectomy in the rat brain: central- and peripheral-type benzodiazepine receptors.
Topics: Animals; Autoradiography; Behavior, Animal; Brain Chemistry; Flumazenil; Flunitrazepam; Isoquinolines; Male; Olfactory Bulb; Peripheral Nervous System; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1994 |
Influence of flumazenil on the learning-enhancing effect of ambocarb in rats.
Topics: Animals; Behavior, Animal; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Discrimination Learning; Discrimination, Psychological; Flumazenil; Flunitrazepam; Harmine; Learning; Ligands; Male; Muscimol; Rats; Rats, Wistar; Receptors, GABA-A | 1994 |
Molecular requirement for anticonvulsant activity in a series of thiazolo-1,4-benzodiazepine derivatives and comparison with classical benzodiazepines.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Benzodiazepines; Binding, Competitive; Body Temperature; Flumazenil; Flunitrazepam; In Vitro Techniques; Injections, Intraperitoneal; Male; Mice; Mice, Inbred DBA; Molecular Weight; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Structure-Activity Relationship; Thiazoles | 1993 |
Zinc selectively inhibits flux through benzodiazepine-insensitive gamma-aminobutyric acid chloride channels in cortical and cerebellar microsacs.
Topics: Animals; Benzodiazepines; Cerebellum; Cerebral Cortex; Chloride Channels; Chlorides; Chlorine; Drug Synergism; Flumazenil; Flunitrazepam; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Kinetics; Radioisotopes; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Stimulation, Chemical; Tritium; Zinc | 1993 |
Effects of midazolam and flunitrazepam on the release of dopamine from rat striatum measured by in vivo microdialysis.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dialysis; Dopamine; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; Homovanillic Acid; Male; Midazolam; Rats; Rats, Sprague-Dawley; Substantia Nigra | 1993 |
Expression and pharmacology of human GABAA receptors containing gamma 3 subunits.
Topics: Amino Acid Sequence; Animals; Anti-Anxiety Agents; Base Sequence; Benzodiazepines; Benzodiazepinones; Carbolines; Flumazenil; Flunitrazepam; GABA Modulators; Humans; Molecular Sequence Data; Pyrazoles; Pyridazines; Pyridines; Receptors, GABA-A; Recombinant Proteins; Sequence Homology, Amino Acid; Triazolam; Xenopus; Zolpidem | 1995 |
Modest reduction of benzodiazepine binding in rat brain in vivo induced by antisense oligonucleotide to GABAA receptor gamma 2 subunit subtype.
Topics: Animals; Base Sequence; Brain Stem; Cerebellum; Cerebral Cortex; Corpus Striatum; Flumazenil; Flunitrazepam; GABA Modulators; Hippocampus; Injections, Intraventricular; Male; Molecular Sequence Data; Oligonucleotides, Antisense; Rats; Rats, Wistar; Receptors, GABA-A | 1995 |
Characterization of a benzodiazepine receptor site with exceptionally high affinity for Ro 15-4513 in the rat CNS.
Topics: Affinity Labels; Animals; Anti-Anxiety Agents; Azides; Benzodiazepines; Binding Sites; Binding, Competitive; Central Nervous System; Cerebellum; Chlorides; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; GABA Modulators; Hippocampus; Imidazoles; Male; Pyridines; Rats; Rats, Wistar; Receptors, GABA-A; Spinal Cord; Tritium | 1995 |
Reciprocal effects of chronic diazepam and melatonin on brain melatonin and benzodiazepine binding sites.
Topics: Animals; Body Weight; Brain; Cerebral Cortex; Diazepam; Flumazenil; Flunitrazepam; Kinetics; Male; Medulla Oblongata; Melatonin; Pons; Rats; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, GABA-A; Receptors, Melatonin | 1996 |
Down-regulation of benzodiazepine receptors by ethyl beta-carboline-3-carboxylate in cerebrocortical neurons.
Topics: Animals; Carbolines; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Down-Regulation; Flumazenil; Flunitrazepam; Mice; Receptors, GABA-A | 1996 |
Diazepam physical dependence and withdrawal in rats is associated with alteration in GABAA receptor function.
Topics: Animals; Benzodiazepines; Cerebral Cortex; Chloride Channels; Chlorides; Diazepam; Flumazenil; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred F344; Receptors, GABA-A; Substance Withdrawal Syndrome; Substance-Related Disorders | 1996 |
Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit.
Topics: Amino Acid Sequence; Anesthetics, Intravenous; Animals; Bicuculline; Brain; Cell Line; Consensus Sequence; DNA, Complementary; Flumazenil; Flunitrazepam; GABA Agents; gamma-Aminobutyric Acid; Humans; Molecular Sequence Data; Muscimol; Pentobarbital; Picrotoxin; Pregnanolone; Propofol; Rats; Receptors, GABA-A; Recombinant Proteins; RNA, Messenger; Transfection | 1997 |
Modulation of long-term potentiation in CA1 region of mouse hippocampal brain slices by GABAA receptor benzodiazepine site ligands.
Topics: Animals; Carbolines; Convulsants; Dizocilpine Maleate; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Antagonists; Flumazenil; Flunitrazepam; GABA-A Receptor Agonists; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Mice; Quinolones; Receptors, GABA-A | 1997 |
Key amino acids in the gamma subunit of the gamma-aminobutyric acidA receptor that determine ligand binding and modulation at the benzodiazepine site.
Topics: Amino Acid Sequence; Animals; Benzodiazepines; Binding Sites; Electrophysiology; Female; Flumazenil; Flunitrazepam; GABA Agonists; GABA Modulators; Ligands; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Receptors, GABA; Sequence Homology, Amino Acid; Xenopus laevis | 1997 |
Rohypnol ("roofies") control of drug discrimination: effect of coadministered ethanol or flumenazil.
Topics: Animals; Anti-Anxiety Agents; Discrimination Learning; Dose-Response Relationship, Drug; Drug Administration Schedule; Ethanol; Flumazenil; Flunitrazepam; GABA Antagonists; Male; Rats; Rats, Sprague-Dawley | 1998 |
The effect of chronic benzodiazepines exposure on body weight in rats.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Body Weight; Diazepam; Dose-Response Relationship, Drug; Female; Flumazenil; Flunitrazepam; GABA Modulators; Male; Nordazepam; Oxazepam; Rats; Rats, Sprague-Dawley; Sex Factors; Time Factors; Weight Gain | 1998 |
Benzodiazepine modulation of recombinant alpha1beta3gamma2 GABA(A) receptor function efficacy determination using the Cytosensor microphysiometer.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Biosensing Techniques; Cell Count; Cells, Cultured; Dose-Response Relationship, Drug; Eukaryotic Cells; Flumazenil; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Humans; Pyridines; Receptors, GABA-A; Recombinant Proteins; Time Factors; Zolpidem | 1998 |
Acute pentylenetetrazol injection reduces rat GABAA receptor mRNA levels and GABA stimulation of benzodiazepine binding with No effect on benzodiazepine binding site density.
Topics: Animals; Autoradiography; Brain; Down-Regulation; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Male; Muscimol; Pentylenetetrazole; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Time Factors; Transcription, Genetic; Tritium | 1999 |
Discrepancy of benzodiazepine receptor occupancy between 3H-flumazenil and 125I-iomazenil in intact mouse brain.
Topics: Animals; Binding, Competitive; Brain; Carbolines; Flumazenil; Flunitrazepam; In Vitro Techniques; Iodine Radioisotopes; Kinetics; Male; Mice; Nitrazepam; Receptors, GABA-A; Triazolam; Tritium | 1999 |
Mutagenesis of the rat alpha1 subunit of the gamma-aminobutyric acid(A) receptor reveals the importance of residue 101 in determining the allosteric effects of benzodiazepine site ligands.
Topics: Allosteric Regulation; Amino Acid Substitution; Animals; Anti-Anxiety Agents; Binding Sites; Flumazenil; Flunitrazepam; Histidine; Ligands; Mutagenesis, Site-Directed; Oocytes; Rats; Receptors, GABA-A; Xenopus laevis | 1999 |
Benzodiazepine receptor ligands. III. Synthesis and biological evaluation of 2- and/or 3-substituted pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxides.
Topics: Animals; Binding, Competitive; Cattle; Flumazenil; Flunitrazepam; GABA Modulators; In Vitro Techniques; Magnetic Resonance Spectroscopy; Pyrazoles; Receptors, GABA-A; Triazines | 1999 |
Identification of benzodiazepine binding site residues in the gamma2 subunit of the gamma-aminobutyric acid(A) receptor.
Topics: Amino Acid Sequence; Azides; Benzodiazepines; Binding Sites; Cells, Cultured; Cloning, Molecular; Flumazenil; Flunitrazepam; Humans; Molecular Sequence Data; Point Mutation; Receptors, GABA-A; Recombinant Fusion Proteins; Sequence Homology, Amino Acid | 2000 |
Continuous intravenous flumazenil infusion for benzodiazepine poisoning.
Topics: Adult; Anti-Anxiety Agents; Antidotes; Female; Flumazenil; Flunitrazepam; Gastric Lavage; Glasgow Coma Scale; Humans; Infusions, Intravenous; Suicide, Attempted | 2000 |
Evaluation of native GABA(A) receptors containing an alpha 5 subunit.
Topics: Alkynes; Animals; Anti-Anxiety Agents; Anticonvulsants; Autoradiography; Benzodiazepines; Cerebellum; Clobazam; Clonazepam; Diazepam; Flumazenil; Flunitrazepam; GABA-A Receptor Agonists; Hippocampus; Imidazoles; Male; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2001 |
[3H]Ro 15-1788 binding sites to brain membrane of the saltwater Mugil cephalus.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Carbolines; Cell Membrane; Chlorides; Diazepam; Female; Fishes; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Imidazoles; Ionophores; Male; Pyridines; Receptors, GABA-A; Synaptosomes; Tritium; Zolpidem | 2001 |
Identification of amino acid residues responsible for the alpha5 subunit binding selectivity of L-655,708, a benzodiazepine binding site ligand at the GABA(A) receptor.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Anti-Anxiety Agents; Azides; Benzodiazepines; Binding Sites; Binding, Competitive; Carbolines; DNA, Complementary; Female; Flumazenil; Flunitrazepam; GABA-A Receptor Agonists; Humans; Imidazoles; Isoleucine; Ligands; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Protein Binding; Protein Structure, Tertiary; Protein Subunits; Pyridazines; Pyridines; Receptors, GABA-A; Recombinant Fusion Proteins; Sequence Alignment; Structure-Activity Relationship; Threonine; Transfection; Xenopus laevis; Zolpidem | 2001 |
[Tetraplegia in the course of coma from drug intoxication].
Topics: Aged; Anti-Anxiety Agents; Antidotes; Female; Flumazenil; Flunitrazepam; Humans; Magnetic Resonance Imaging; Quadriplegia; Regional Blood Flow; Spinal Cord; Suicide | 2001 |
Modulation of radioligand binding to the GABA(A)-benzodiazepine receptor complex by a new component from Cyperus rotundus.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Cyperaceae; Flumazenil; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Plant Extracts; Plant Roots; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sesquiterpenes | 2002 |
Mechanism of alpha-subunit selectivity of benzodiazepine pharmacology at gamma-aminobutyric acid type A receptors.
Topics: Animals; Anti-Anxiety Agents; Binding, Competitive; Cell Line; Diazepam; Dose-Response Relationship, Drug; Female; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Membrane Potentials; Mutation; Oocytes; Protein Subunits; Pyridazines; Pyridines; Radioligand Assay; Receptors, GABA-A; Tritium; Xenopus laevis; Zolpidem | 2002 |
Normal coupling of brain benzodiazepine and neurosteroid modulatory sites on the GABA-A receptor complex in human hepatic encephalopathy.
Topics: Adult; Aged; Aged, 80 and over; Brain; Female; Flumazenil; Flunitrazepam; Hepatic Encephalopathy; Humans; Intracranial Aneurysm; Kinetics; Male; Middle Aged; Muscimol; Receptors, GABA-A; Reference Values; Shock, Septic | 2003 |
Chronic exposure of cells expressing recombinant GABAA receptors to benzodiazepine antagonist flumazenil enhances the maximum number of benzodiazepine binding sites.
Topics: Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cell Membrane; Diazepam; Dose-Response Relationship, Drug; Drug Combinations; Flumazenil; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Humans; Kidney; Ligands; Receptors, GABA-A; Recombinant Proteins; Tritium | 2004 |
Effects of kava-kava extract on the sleep-wake cycle in sleep-disturbed rats.
Topics: Animals; Delta Rhythm; Dose-Response Relationship, Drug; Electromyography; Flumazenil; Flunitrazepam; GABA Modulators; Kava; Male; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Sleep Initiation and Maintenance Disorders; Sleep, REM | 2005 |
Characterization in rats of the anxiolytic potential of ELB139 [1-(4-chlorophenyl)-4-piperidin-1-yl-1,5-dihydro-imidazol-2-on], a new agonist at the benzodiazepine binding site of the GABAA receptor.
Topics: Animals; Anti-Anxiety Agents; Binding Sites; Binding, Competitive; Conflict, Psychological; Diazepam; Drug Tolerance; Flumazenil; Flunitrazepam; GABA Agonists; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Imidazoles; Light; Male; Membrane Potentials; Patch-Clamp Techniques; Piperidines; Rats; Rats, Wistar | 2005 |
Differential effects of ammonia on the benzodiazepine modulatory site on the GABA-A receptor complex of human brain.
Topics: Ammonia; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Dose-Response Relationship, Drug; Down-Regulation; Flumazenil; Flunitrazepam; GABA Agonists; GABA Modulators; Hepatic Encephalopathy; Humans; Hyperammonemia; Ligands; Muscimol; Radioligand Assay; Receptors, GABA-A; Subcellular Fractions; Synaptic Transmission; Tartrates | 2005 |
Novel plant substances acting as beta subunit isoform-selective positive allosteric modulators of GABAA receptors.
Topics: Allosteric Regulation; Animals; Araliaceae; Bicuculline; Flumazenil; Flunitrazepam; GABA Modulators; Picrotoxin; Plant Extracts; Receptors, GABA-A; Xenopus laevis | 2005 |
Allosteric uncoupling and up-regulation of benzodiazepine and GABA recognition sites following chronic diazepam treatment of HEK 293 cells stably transfected with alpha1beta2gamma2S subunits of GABA (A) receptors.
Topics: Allosteric Regulation; Animals; Benzodiazepines; Binding Sites; Binding, Competitive; Cell Line; Diazepam; Flumazenil; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Muscimol; Picrotoxin; Protein Subunits; Pyridazines; Radioligand Assay; Rats; Receptors, GABA-A; Receptors, GABA-B; Transfection; Up-Regulation | 2007 |
Contribution of specific binding to the central benzodiazepine site to the brain concentrations of two novel benzodiazepine site ligands.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Binding Sites; Binding, Competitive; Brain; Brain Chemistry; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; GABA Modulators; GABA-A Receptor Agonists; Injections, Intravenous; Ligands; Male; Mice; Mice, Mutant Strains; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Tissue Distribution; Triazines | 2007 |
The role of transcriptional and translational mechanisms in flumazenil-induced up-regulation of recombinant GABA(A) receptors.
Topics: Analysis of Variance; Cell Line, Transformed; Cell Proliferation; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Drug Interactions; Flumazenil; Flunitrazepam; GABA Modulators; Humans; Muscimol; Protein Biosynthesis; Protein Synthesis Inhibitors; Receptors, GABA-A; RNA, Messenger; Transcription, Genetic; Transcriptional Activation; Transfection; Tritium; Up-Regulation | 2008 |
Menthol shares general anesthetic activity and sites of action on the GABA(A) receptor with the intravenous agent, propofol.
Topics: Anesthetics, General; Anesthetics, Intravenous; Animals; Cyclohexanols; Flumazenil; Flunitrazepam; Menthol; Pentobarbital; Pregnanolone; Propofol; Receptors, GABA-A; Xenopus | 2008 |
6,3'-Dinitroflavone is a low efficacy modulator of GABA(A) receptors.
Topics: Animals; Anti-Anxiety Agents; Cell Line; Chlorides; Female; Flavonoids; Flumazenil; Flunitrazepam; GABA Modulators; Humans; Oocytes; Patch-Clamp Techniques; Protein Binding; Protein Subunits; Receptors, GABA-A; Transfection; Xenopus | 2008 |
A high-throughput functional assay for characterization of gamma-aminobutyric acid(A) channel modulators using cryopreserved transiently transfected cells.
Topics: Carbolines; Cell Culture Techniques; Cell Line; Cell Membrane; Cryopreservation; Diazepam; DNA; Dose-Response Relationship, Drug; Drug Discovery; Flumazenil; Flunitrazepam; Fluorescent Dyes; Fluorobenzenes; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Membrane Potentials; Receptors, GABA-A; Reproducibility of Results; Spectrometry, Fluorescence; Transfection; Triazoles; Tritium | 2008 |
The effects of benzodiazepines on urotensin II-stimulated norepinephrine release from rat cerebrocortical slices.
Topics: Animals; Benzodiazepines; Benzoxazoles; Calcium Signaling; Cell Line; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; GABA-A Receptor Agonists; Humans; Hypnotics and Sedatives; In Vitro Techniques; Male; Midazolam; Naphthyridines; Norepinephrine; Orexin Receptors; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, GABA-A; Receptors, Neuropeptide; Transfection; Urea; Urotensins | 2009 |
The localization of inhibitory neurotransmitter receptors on dopaminergic neurons of the human substantia nigra.
Topics: Aged; Aged, 80 and over; Autoradiography; Dopamine; Female; Flumazenil; Flunitrazepam; Humans; Male; Middle Aged; Neurons; Postmortem Changes; Protein Isoforms; Receptors, GABA-A; Receptors, GABA-B; Receptors, Glycine; Substantia Nigra; Tritium | 2009 |
Remarkable selectivity of the in vivo binding of [3H]Ro15-4513 to α5 subtype of benzodiazepine receptor in the living mouse brain.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Binding, Competitive; Brain; Carbolines; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; Male; Mice; Protein Subunits; Receptors, GABA-A; Tritium | 2010 |
Comparing the discriminative stimuli produced by either the neuroactive steroid pregnanolone or the benzodiazepine midazolam in rats.
Topics: Animals; Behavior, Animal; Discrimination, Psychological; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; GABA Modulators; Male; Midazolam; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2011 |
Quantitative analyses of antagonism: combinations of midazolam and either flunitrazepam or pregnanolone in rhesus monkeys discriminating midazolam.
Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Female; Flumazenil; Flunitrazepam; Macaca mulatta; Midazolam; Pregnanolone; Receptors, GABA-A | 2012 |
Discriminative stimulus effects of pregnanolone in rhesus monkeys.
Topics: Animals; Conditioning, Operant; Data Interpretation, Statistical; Discrimination, Psychological; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Flumazenil; Flunitrazepam; GABA Modulators; Gonadal Steroid Hormones; Hypnotics and Sedatives; Isoxazoles; Macaca mulatta; Male; Midazolam; Pregnanolone; Receptors, GABA-A; Reinforcement Schedule | 2014 |
Hops compounds modulatory effects and 6-prenylnaringenin dual mode of action on GABA
Topics: Animals; Azides; Benzodiazepines; Binding, Competitive; Cyclohexenes; Dose-Response Relationship, Drug; Flavonoids; Flumazenil; Flunitrazepam; GABA Modulators; Humulus; Male; Molecular Docking Simulation; Plant Extracts; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Terpenes | 2020 |