flumazenil has been researched along with diazepam in 733 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 262 (35.74) | 18.7374 |
| 1990's | 266 (36.29) | 18.2507 |
| 2000's | 140 (19.10) | 29.6817 |
| 2010's | 53 (7.23) | 24.3611 |
| 2020's | 12 (1.64) | 2.80 |
| Authors | Studies |
|---|---|
| Bianucci, AM; Da Settimo, A; Da Settimo, F; Giannaccini, G; Lucacchini, A; Martini, C; Primofiore, G | 1 |
| Cecchi, L; Colotta, V; Filacchioni, G; Giannaccini, G; Lucacchini, A; Martini, C; Melani, F | 1 |
| Baker, R; Engelstoff, M; Herbert, R; Knight, A; MacLeod, A; Merchant, K; Moseley, J; Saunders, J; Swain, CJ; Watjen, F | 1 |
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Barone, D; Gallico, L; Luzzani, F; Tarzia, G; Toja, E | 1 |
| Lüddens, H; Wieland, HA | 1 |
| de Costa, BR; Dominguez, C; Gu, ZQ; Rice, KC; Skolnick, P; Wong, G | 1 |
| Basile, AS; Fryer, RI; Gu, ZQ; Rios, R; Skolnick, P; Zhang, P | 1 |
| Catarzi, D; Cecchi, L; Colotta, V; Costagli, C; Filacchioni, G; Galli, A; Varano, F | 1 |
| Da Settimo, A; Da Settimo, F; Gesi, M; Giannaccini, G; Greco, G; Lucacchini, A; Marini, AM; Martini, C; Novellino, E; Primofiore, G | 1 |
| Aiello, PM; Bruni, F; Ciciani, G; Costa, B; Costanzo, A; Guerrini, G; Ipponi, A; Lucacchini, A; Martini, C; Selleri, S | 1 |
| Dekermendjian, K; Kahnberg, P; Liljefors, T; Nielsen, M; Sterner, O; Witt, MR | 1 |
| Cook, JM; Dayer, CA; He, X; Huang, Q; Liu, R; Ma, C; McKernan, R; Wenger, GR; Yu, S | 1 |
| Da Settimo, F; Gesi, M; Greco, G; La Motta, C; Marini, AM; Martini, C; Novellino, E; Primofiore, G; Taliani, S; Trincavelli, L | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Besnard, F; Bruni, F; Ciciani, G; Costa, B; Costagli, C; Costanzo, A; Guerrini, G; Malmberg-Aiello, P; Martini, C; Selleri, S | 1 |
| Kuribara, H; Maruyama, Y; Weintraub, ST; Yoshihama, T | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Besnard, F; Cosimelli, B; Costa, B; Da Settimo, F; Greco, G; Martini, C; Montali, M; Novellino, E; Primofiore, G; Salerno, S; Taliani, S | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Besnard, F; Cosimelli, B; Da Settimo, F; Ehlardo, M; Greco, G; La Motta, C; Marini, AM; Martini, C; Montali, M; Novellino, E; Primofiore, G; Sala, A; Simorini, F; Taliani, S | 1 |
| Besnard, F; Calderone, V; Cosimelli, B; Da Settimo, F; Greco, G; La Motta, C; Marini, AM; Martini, C; Montali, M; Novellino, E; Patrizi, MP; Primofiore, G; Sergianni, V; Simorini, F; Taliani, S | 1 |
| Bruni, F; Cambi, G; Ciciani, G; Costanzo, A; Ghelardini, C; Guerrini, G; Martini, C; Melani, F; Montali, M; Norcini, M; Selleri, S | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Clayton, T; Cook, J; DeLorey, TM; Furtmüller, R; Halliwell, RF; Harris, D; Huck, S; Sahbaie, P; Sieghart, W | 1 |
| Anzini, M; Betti, L; Braile, C; Cappelli, A; Ghelardini, C; Giannaccini, G; Giorgi, G; Ian Fryer, R; Limongelli, V; Lucacchini, A; Makovec, F; Marinelli, L; Norcini, M; Novellino, E; Valenti, S; Vomero, S | 1 |
| Ahman, M; Holmén, AG; Wan, H | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Bruni, F; Cambi, G; Ciciani, G; Costanzo, A; Ghelardini, C; Guarino, C; Guerrini, G; Martini, C; Melani, F; Montali, M; Norcini, M; Selleri, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Bruni, F; Ciattini, S; Ciciani, G; Costanzo, A; Daniele, S; Ghelardini, C; Guarino, C; Guerrini, G; Martini, C; Melani, F; Montali, M; Norcini, M; Selleri, S | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Alcaro, S; Anzini, M; Betti, L; Biggio, G; Braile, C; Cappelli, A; Daniele, S; Di Cesare Mannelli, L; Ghelardini, C; Giannaccini, G; Giorgi, G; Limongelli, V; Lucacchini, A; Marinelli, L; Martini, C; Mascia, MP; Novellino, E; Ortuso, F; Valenti, S; Vomero, S | 1 |
| Bagal, SK; Brown, AD; Cox, PJ; Omoto, K; Owen, RM; Pryde, DC; Sidders, B; Skerratt, SE; Stevens, EB; Storer, RI; Swain, NA | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Anzini, M; Betti, L; Biggio, G; Braile, C; Cappelli, A; Castriconi, F; Di Capua, A; Di Cesare Mannelli, L; Frosini, M; Ghelardini, C; Giannaccini, G; Giorgi, G; Giuliani, G; Grisci, G; Lucacchini, A; Mascia, MP; Paolino, M; Ricci, L; Valenti, S; Vomero, S | 1 |
| Anzini, M; Brogi, S; Cappelli, A; Chemi, G; Di Capua, A; Di Cesare Mannelli, L; Garofalo, A; Ghelardini, C; Giorgi, G; Grande, F; Matucci, R; Paolino, M; Reale, A | 1 |
| Davies, MF; Loew, GH; Maguire, PA; Villar, HO | 1 |
| Facklam, M; Haefely, WE; Schoch, P | 1 |
| Bonetti, EP; Facklam, M; Haefely, WE; Jenck, F; Martin, JR; Moreau, JL; Schoch, P | 1 |
| Arakawa, K; Benson, KT; Goto, H; Yokoyama, M | 1 |
| Järvinen, A; Männistö, PT; Rägo, L | 1 |
| Inano, S | 1 |
| Dudley, MW; Kane, JM; Kehne, JH; Miller, JA; Sorensen, SM | 1 |
| Coale, A; Friedhoff, AJ; Gruen, RJ; Moghaddam, B | 1 |
| Fukuda, N; Wada, T | 4 |
| McNamara, RK; Skelton, RW | 2 |
| Hönack, D; Löscher, W | 2 |
| Hirose, A; Kumasaka, Y; Nakamura, M; Shimizu, H; Tanaka, H | 1 |
| Barlin, GB; Davies, LP; Ireland, SJ; Ngu, MM | 1 |
| Bernasconi, R; Leonhardt, T; Martin, P; Portet, C; Schmutz, M; Steulet, AF | 1 |
| Gröger, P; Kettler, D; Kolenda, H; Michaelis, HC; Steinwachs, M; Sydow, M | 1 |
| Brain, PF; Kurishingal, H; Restall, CJ | 1 |
| Gallagher, LV; Greene, SA; Keegan, RD; Moore, MP | 1 |
| Almog, S; Ezra, D; Mordel, A; Tirosh, M; Winkler, E | 1 |
| Boone, MS; Emmett-Oglesby, MW; Pugh, SL | 1 |
| Sim, MK; Tsoi, WF | 1 |
| Ator, NA; Griffiths, RR | 2 |
| File, SE; Hitchcott, PK; Zharkovsky, A | 1 |
| Gallaher, EJ; Phillips, TJ | 1 |
| Tietz, EI | 1 |
| Mori, K; Murayama, T; Ogawa, T; Shindo, K; Shingu, K; Tamai, S; Tomoda, K | 1 |
| Hart, YM; Meinardi, H; Nutt, DJ; Sander, JW; Shorvon, SD | 2 |
| Basile, AS; Harrison, PM; Hughes, RD; Jones, EA; Murata, Y; Pannell, L; Skolnick, P; Williams, R | 1 |
| Backus, KH; Pflimlin, P; Trube, G | 1 |
| Agmo, A; Fernández, H | 1 |
| al-Tikriti, MS; Baldwin, RM; Innis, RB; Johnson, EW; Laruelle, MA; Malison, RT; Seibyl, JP; Sybirska, EH; Zimmermann, RC; Zoghbi, SS | 1 |
| Bottlaender, M; Brouillet, E; Chavoix, C; Dodd, RH; Fournier, D; Hantraye, P; Khalili-Varasteh, M; Mazière, M | 1 |
| Allen, M; Cook, JM; Griffiths, RR; Sannerud, CA | 1 |
| Bitran, D; Ison, JR; Kellogg, CK; Sullivan, AT | 1 |
| Engel, JA; Söderpalm, B | 1 |
| Little, HJ | 1 |
| Engel, JA; Hulthe, P; Johannessen, K; Söderpalm, B; Svensson, L | 1 |
| Inoue, Y; Ohno, M; Shibata, S; Teshima, K; Tominaga, K; Ueki, S; Ushio, M; Watanabe, S; Yamamoto, T | 1 |
| Franklin, SR; Tang, AH | 1 |
| Blasquez, C; Braquet, P; Delbende, C; Jégou, S; Tranchand Bunel, D; Vaudry, H | 1 |
| Franklin, SR; Himes, CS; Ho, PM; Tang, AH | 1 |
| Dickey, KM; Martin, WR; Sloan, JW; Wala, E | 1 |
| Hernández, J | 1 |
| Kaneyuki, H; Mizuki, Y; Tanaka, M; Tsuda, A; Yamada, M; Yokoo, H; Yoshida, M | 1 |
| Coates, W; Evans, TC; Harchelroad, F; Isaacs, M; Jehle, D | 1 |
| De Meo, F; De Meo, M; Fellico, C; Ferone, A; Gaeta, N | 1 |
| Consiglio, F; De Lisio, C; Finelli, B; Iannotti, M; Pace, MC; Passavanti, MB | 1 |
| Suzuki, H | 1 |
| Blakeman, DP; Im, WB | 1 |
| Basile, AS | 1 |
| Simon, A | 1 |
| Flemström, G; Jedstedt, G; Säfsten, B | 1 |
| Andersen, B; Forrest, M; Gjørup, I; Vilien, M | 1 |
| Nagatani, T; Yamamoto, T | 1 |
| Cruccu, G; Fabbri, A; Ferracuti, S; Leardi, MG; Manfredi, M | 1 |
| Bing, LH; Matsumoto, K; Ohta, H; Satoh, T; Watanabe, H | 1 |
| Martin, WR; Sloan, JW; Wala, EP | 3 |
| De Luca, C; De Medici, D; Massotti, M | 1 |
| Devi, K; Hrishikeshavan, HJ; Munonyedi, S; Shanbhogue, R | 1 |
| Doenicke, A; Greim, M; Juhl, G; Rampf, U; Suttmann, H | 1 |
| Biggio, G; Carcangiu, G; Concas, A; Mereu, G; Passino, N | 1 |
| Budhram, P; Deacon, RM; Gardner, CR; Thomson, TA | 1 |
| Izquierdo, I; Medina, JH; Pereira, ME | 1 |
| File, SE; Hitchcott, PK | 1 |
| Hicks, TP; Oka, JI | 1 |
| Borsini, F; D'Aranno, V; Lecci, A; Mancinelli, A; Meli, A; Stasi, MA; Volterra, G | 1 |
| Kucharik, RF; Lucki, I | 1 |
| Elgoyhen, AB; Kazanietz, MG | 1 |
| McCloy, RF; Pearson, RC | 1 |
| Blanchard, JC; Boireau, A; Doble, A; Dubedat, P; Laduron, PM | 1 |
| Hole, K; Rosland, JH | 1 |
| Chernilas, J; Geller, E; Halpern, P; Miller, HB; Niv, D | 1 |
| Isaac, PA; Okell, RW; Piggott, SE; Roberts, B; Robinson, JO; Rosen, M; Sanders, LD | 1 |
| Kadiwar, RM; Pillay, R | 1 |
| Knudsen, J; Nielsen, M | 1 |
| Bauerle, LM; DeNoble, VJ; Jones, KW; Schaeffer, CL | 1 |
| Fernández-Guasti, A; Roldán-Roldán, G; Saldívar, A | 1 |
| Chapouthier, G; Dodd, RH; Raffalli-Sebille, MJ; Venault, P | 1 |
| Coenen, AM; Nutt, DJ; Peeters, BW; Titulaer, MN; Van Rijn, CM; Vossen, JM | 1 |
| Ida, Y; Nishimura, H; Tanaka, M | 1 |
| McNamara, RK; Whishaw, IQ | 1 |
| Bogdanov, NN; Molodavkin, GM; Voronina, TA | 1 |
| Amaki, Y; Hajiri, H; Kaneko, M; Kobayashi, K; Kumagai, M; Shudo, Y | 1 |
| Briley, M; Lerner-Natoli, M; Rondouin, G; Stenger, A | 1 |
| Ceckler, T; Guillet, R; Kellogg, C; Miranda, R | 1 |
| Nagatani, T; Sugihara, T; Takao, K; Ueki, S; Yamamoto, T | 1 |
| Di Scala, G; Rohmer, JG; Sandner, G | 1 |
| Blier, P; de Montigny, C; Lista, A | 2 |
| Corda, MG; Fratta, W; Orlandi, M | 1 |
| Giros, B; Llorens-Cortes, C; Quach, TT; Schwartz, JC; Van Amsterdam, JG | 1 |
| Deutsch, SI; Huntzinger, JA; Mastropaolo, J; Novitzki, MR; Rosse, RB | 1 |
| Dragunow, M | 1 |
| Myers, RD; Paez, X | 1 |
| Baartmans, MG; Kopp, EF; Oudesluys-Murphy, AM | 1 |
| Lopez, A; Rebollo, J | 1 |
| Hashida, T; Katoh, H; Kawamoto, T; Mishima, S; Mori, K; Murakawa, M; Sasai, S; Urabe, N; Yamaoka, H | 1 |
| Amaki, Y; Horiguchi, T; Kobayashi, K; Takinami, M | 1 |
| Doi, M; Ikeda, K | 1 |
| Hashemi, FS; Niles, LP | 1 |
| Fuccaro, P; Mantero, L; Mazzarello, MR; Roccatagliata, DC; Sburlati, E | 1 |
| Hill, JL; Insel, TR; Mayor, RB | 1 |
| Crespi, F; Keane, PE | 1 |
| Haefely, W | 1 |
| Hernández, J; Pérez, D; Ruiz, F | 1 |
| Adler-Graschinsky, E; Elgoyhen, B | 1 |
| Fillenz, M; Pei, Q; Zetterström, T | 1 |
| Jensen, S; Kirkegaard, L; Knudsen, EB; Knudsen, L; Kruse, A | 1 |
| Mora, CT; Torjman, M; White, PF | 1 |
| Bursztein, S | 1 |
| Block, RI; Dembo, JB; Ghoneim, MM | 1 |
| Koot, M; Van Duin, CT; Van Miert, AS | 1 |
| Belknap, JK; Crabbe, JC; Laursen, SE | 1 |
| Kovács, I; Maksay, G; Simonyi, M | 1 |
| Ida, Y; Nishimura, H; Tanaka, M; Tsuda, A | 1 |
| Cherniack, NS; Deal, EC; Haxhiu, MA; van Lunteren, E | 1 |
| Ida, Y; Shirao, I; Sueyoshi, K; Tanaka, M; Tsuda, A | 1 |
| Andersen, P; Christiansen, C; Jarnvig, IL; Jørgensen, B; Skielboe, M; Weber, M | 1 |
| Gallager, DW; Heninger, C; Hernandez, TD; Wilson, MA | 1 |
| Gallager, DW; Wilson, MA | 2 |
| Bodnoff, SR; Meaney, MJ; Quirion, R; Suranyi-Cadotte, BE | 1 |
| Bachy, A; Cordeau, LR; Croizat, BP; Gros, F; Keane, PE; Larcher, JC; Le Marquer, FJ; Vayssiere, JL | 1 |
| Innes, DG; Kavaliers, M | 2 |
| Canonaco, M; McEwen, BS; O'Connor, LH; Pfaff, DW | 1 |
| Hernandez, TD; Jones, GH; Schallert, T | 1 |
| Harary, N; Kellogg, C | 1 |
| Lüddens, H; Pritchett, DB; Seeburg, PH | 1 |
| Albertson, TE; Joy, RM | 1 |
| Barth, TM; Bowery, NG; Moratalla, R | 1 |
| Kellogg, CK; Miranda, RC; Wagner, JP | 1 |
| Kaneto, H; Takahashi, M; Tokuyama, S | 1 |
| Appel, M; Bron, HN; Hooymans, PM; Janknegt, R | 1 |
| Gavish, M; Katz, Y | 1 |
| Fassbender, CP; Hönack, D; Löscher, W | 1 |
| Antelman, SM; Edwards, DJ; Knopf, S; Kocan, D | 1 |
| Bizière, K; Fournier, M; Keane, P; Santucci, V; Worms, P | 1 |
| Garamvölgyi, G; Hamar, O; Kálmán, A | 1 |
| Costall, B; Jones, BJ; Kelly, ME; Naylor, RJ; Oakley, NR; Onaivi, ES; Tyers, MB | 1 |
| Cooper, SJ; Estall, LB | 1 |
| Crabbe, JC; Gallaher, EJ; Gionet, SE; Hollister, LE | 1 |
| Dan'ura, T; Ishibashi, S; Kurokawa, T; Yamashita, A; Yanagiuchi, H | 1 |
| Randall, JI; Rodgers, RJ | 3 |
| Cox, DH; Guidotti, A; Santi, MR | 1 |
| Hanada, S; Hashimoto, S; Tanaka, C; Taniyama, K | 1 |
| Nagatani, T; Sugihara, T; Ueki, S; Yamamoto, T | 1 |
| Biggio, G; Corda, MG; Fernández, A; Giorgi, O | 1 |
| Jensen, S; Kirkegaard, L; Knudsen, L | 1 |
| Dunton, AW; Hendler, J; McGrath, J; Pitman, V; Schwam, E; Siegel, J | 1 |
| Dan'ura, T; Ishibashi, S; Kurokawa, T; Une, Y; Yamashita, A | 1 |
| Arbilla, S; Langer, SZ; Lista, A | 1 |
| Brown, CL; Dodd, RH; Potier, MC; Prado de Carvalho, L; Rossier, J | 1 |
| Hawkins, M; Pravica, M; Radulovacki, M | 1 |
| Blanchard, JC; Boireau, A; Dubédat, P; Farges, G; Laduron, PM; Martel, M | 1 |
| Kuga, T; Moroi, K; Takashi, K | 1 |
| De Medici, D; Gatta, F; Longo, VG; Massotti, M | 1 |
| Marczynski, TJ; Urbancic, M | 1 |
| Mehta, AK; Mhatre, M; Ticku, MK | 1 |
| Lister, RG | 1 |
| Bonetti, EP; Burkard, WP; Gabl, M; Hunkeler, W; Lorez, HP; Martin, JR; Moehler, H; Osterrieder, W; Pieri, L; Polc, P | 1 |
| Chiu, TH; Rosenberg, HC | 3 |
| Hofer, P; Scollo-Lavizzari, G | 1 |
| Griffiths, RR; Lamb, RJ | 2 |
| Kubota, K; Matsuda, I; Matsuoka, Y; Sugaya, K; Terawaki, Y | 1 |
| Klockgether, T; Schwarz, M; Sontag, KH; Turski, L | 1 |
| Le Bihan, C; Simon, P; Soubrié, P; Thiébot, MH | 1 |
| Ellis, S; Foltin, RW; Schuster, CR | 1 |
| Spealman, RD | 2 |
| Spealman, RD; Wettstein, JG | 2 |
| Barrett, JE; Mansbach, RS; Skolnick, P; Weissman, BA; Witkin, JM | 1 |
| Ueki, S; Yamamoto, T | 1 |
| Crul, JF; Driessen, JJ; van der Pol, F; van Egmond, J | 1 |
| Albertson, TE; Foulke, GE | 1 |
| O'Brien, DP; White, FJ | 1 |
| Biziere, K; Keane, PE; Morre, M; Simiand, J | 1 |
| Davis, M; Gallager, DW | 1 |
| O'Regan, MH; Phillis, JW | 1 |
| Concas, A; Morelli, M; Obata, T; Serra, M; Yamamura, HI | 1 |
| Elsasser, S; Ritz, R; Schwander, J | 1 |
| De Deyn, PP; Macdonald, RL | 2 |
| Benkert, O; Heuser, I; Wetzel, H | 1 |
| Fillenz, M; Fung, SC | 1 |
| Biggio, G; Concas, A; Corda, MG; Crisponi, G; Nurchi, V; Serra, M | 1 |
| Böke-Kuhn, K; Danneberg, PB; Hommer, D; Kuhn, FJ; Lehr, E; Paul, SM; Skolnick, P; Weber, KH | 1 |
| Kempner, ES; Paul, SM; Schwartz, RD; Skolnick, P; Thomas, JW | 1 |
| Capek, R; Davies, MF; Esplin, B | 1 |
| Moura, D; Soares-da-Silva, P | 1 |
| Consolo, S; Forloni, G; Garattini, S; Kolasa, K; Ladinsky, H | 1 |
| Caporali, MG; Gatta, F; Lucantoni, D; Massotti, M; Mele, L | 1 |
| Romstedt, K | 1 |
| Dingledine, R; King, GL; Knox, JJ | 1 |
| Bamonte, F; Guzzon, V; Marzanatti, M; Monopoli, A; Ongini, E | 1 |
| Paul, SM; Reed, GF; Skolnick, P | 1 |
| Biggio, G; Concas, A; Corda, MG | 1 |
| Abraham, CJ; De Blas, AL; Haney, SA; Park, D; Rayner, CA; Sangameswaran, L | 1 |
| Cole, R; De Vellis, J; Noble, EP; Syapin, PJ | 1 |
| Fares, F; Gavish, M | 1 |
| Bourn, WM; Garrett, RL | 1 |
| Ehrin, E; Eriksson, L; Farde, L; Hedström, CG; Litton, JE; Mindus, P; Persson, A; Sedvall, G | 1 |
| Ida, Y; Nagasaki, N; Tanaka, M; Tsuda, A; Tsujimaru, S | 1 |
| Agarwal, AK; Gulati, A; Kumar, P; Sethi, BB; Sethi, N; Trivedi, JK | 1 |
| Meiners, BA; Salama, AI | 1 |
| Adinoff, B; Linnoila, M; Majchrowicz, E; Martin, PR | 1 |
| Barrett, JE; Cook, JM; Larscheid, P; Witkin, JM | 1 |
| Hicks, TP; Jang, EK; Oka, JI | 1 |
| Bryere, P; Naquet, R; Valin, A | 1 |
| Biggio, G; Corda, MG | 1 |
| Ayhan, IH; Palaoğlu, O | 2 |
| Glowa, JR; Paul, SM; Skolnick, P | 1 |
| Kulkarni, SK; Kunchandy, J | 1 |
| Astier, H; Roussel, JP; Tapia-Arancibia, L | 1 |
| Biziere, K; Bourguignon, JJ; Chambon, JP; Heaulme, M; Perio, A; Tebib, S; Wermuth, CG | 1 |
| Biggio, G; Carcangiu, P; Corda, MG; Giorgi, O; Mereu, G | 1 |
| Bender, AS; Hertz, L | 1 |
| Barksdale, CM; Kalin, NH; Shelton, SE | 1 |
| Goldstein, JM; Malick, JB; Sutton, EB | 1 |
| Ciuffi, M; Franchi-Micheli, S; Luzzi, S; Rosi, E; Spagnesi, S; Zilletti, L | 1 |
| Gwee, MC; Wong, PT; Yoong, YL | 1 |
| Chiba, S; Haruta, K; Homma, N; Iwatsuki, K; Yamagishi, F | 1 |
| Itoh, Y; Nishibori, M; Oishi, R; Saeki, K | 1 |
| Ferrario, P; Hafner, B; Mantegazza, P; Tammiso, R; Zambotti, F; Zonta, N | 1 |
| Michenfelder, JD; Milde, JH; Roald, OK; Steen, PA | 1 |
| Martin, WR; McNicholas, LF | 2 |
| Dhawan, BN; Gulati, A; Singh, HK; Srimal, RC | 1 |
| Katzman, NJ; Shannon, HE | 1 |
| Biziere, K; Calassi, R; Chambon, JP; Heaulme, M; Perio, A | 1 |
| Sanger, DJ | 1 |
| Albertson, TE; Walby, WF | 1 |
| Teo, WL; Wong, PT | 1 |
| Jensen, S; Kirkegaard, L; Knudsen, L; Kruse, A | 1 |
| Gallager, DW; Heninger, G; Heninger, K | 1 |
| Eison, MS | 1 |
| Levin, ED; Liebeskind, JC; Morgan, MM | 1 |
| Dodgson, MS; Emhjellen, S; Skeie, B; Steen, PA; Wickstrøm, E | 1 |
| Crawford, RD; Johnson, DD; Pedder, SC; Tuchek, JM; Wilcox, R | 1 |
| Iwasawa, H; Naito, H; Tonoue, T | 1 |
| Engel, J; Hård, E | 1 |
| Idemudia, SO; Lal, H; Mathis, DA | 1 |
| Jones, GH; Mittleman, G; Robbins, TW | 1 |
| Lanore, JJ; Manfredi, R; Sockeel, F; Tannières, ML; Vourc'h, G | 1 |
| Kanto, J; Klotz, U | 1 |
| Martin, WR; McNicholas, LF; Sloan, JW; Wala, E | 1 |
| Kataoka, Y; Kumakura, K; Ohara-Imaizumi, M; Ueki, S | 1 |
| Kunert-Radek, J; Pawlikowski, M; Radek, A; Stepien, H | 1 |
| Pacilli, P; Sicignano, A; Spinelli, P | 1 |
| Chiu, TH; Rosenberg, HC; Yu, O | 1 |
| Cagiano, R; Cuomo, V; De Salvia, MA; Maselli, MA; Racagni, G; Renna, G | 1 |
| Malick, JB; Patel, JB; Rinarelli, CA | 1 |
| Aitken, DH; Bodnoff, SR; Meaney, MJ; Quirion, R; Suranyi-Cadotte, B | 1 |
| Gelb, AW; Ume, EO | 1 |
| Kawasaki, K; Matsushita, A; Satoh, M; Takagi, H | 1 |
| Kavaliers, M | 1 |
| Hernández, J; Ribeiro, JA; Ruiz, F | 1 |
| Hiltunen, AJ; Järbe, TU | 1 |
| Emmett-Oglesby, MW; Harris, CM; Idemudia, SO; Lal, H; Mathis, DA | 1 |
| Fenerty, JP; Finkelstein, MF; Galloway, MP; Grant, SJ; Mayor, R; Redmond, DE; Roth, RH | 1 |
| Longo, VG; Sagratella, S | 1 |
| Klockgether, T; Pardowitz, I; Schwarz, M; Sontag, KH; Turski, L | 1 |
| Glushankov, PG; Skrebitskiĭ, VG; Vorob'ev, VS | 1 |
| Ableitner, A; Herz, A; Wüster, M | 1 |
| Caccia, S; Ceci, A; Garattini, S; Masturzo, P; Mennini, T; Salmona, M | 1 |
| Barone, D; Colombo, G; Glasser, A; Luzzani, F; Mennini, T | 1 |
| Belin, C; Carriot, T; Dubroeucq, MC; Guérémy, C; Le Fur, G; Mestre, M; Renault, C; Uzan, A | 1 |
| Braestrup, C; Honoré, T; Jensen, LH; Kehr, W; Petersen, EN; Schmiechen, R; Schneider, H; Seidelmann, D; Stephens, DN | 1 |
| Kawasaki, K; Kodama, M; Matsushita, A | 1 |
| Morin, AM | 1 |
| Daniel, M; Dubroeucq, MC; Gauthier, A; Gueremy, C; Mazadier, M; Mizoule, J; Ollat, C; Rataud, J; Renault, C; Uzan, A | 1 |
| Mendelson, WB | 1 |
| Assié, MB; Briley, M; Charveron, M; Stenger, A | 1 |
| Caputti, E; Cardinali, DP; Lowenstein, PR; Rosenstein, R | 1 |
| Sansone, M | 1 |
| Gherezghiher, T; Lal, H | 1 |
| De Bonnel, G; De Montigny, C | 1 |
| Bernard, P; Cassidy, JP; Czernik, AJ; Petrack, B; Yokoyama, N | 1 |
| Ongini, E | 1 |
| Baldino, F; Blumstein, LK; Crawley, JN | 1 |
| Macdonald, RL; Skerritt, JH | 1 |
| Amato, M; Bizzi, A; Garattini, S; Ricci, MR; Veneroni, E | 1 |
| Bichard, AR; Little, HJ | 1 |
| Engel, JA; Liljequist, S | 1 |
| Overstreet, D; Pilotto, R; Singer, G | 1 |
| Clark, JD; Hatch, RC; Kitzman, JV; Zahner, JM | 1 |
| File, SE | 1 |
| Phillis, JW | 1 |
| Burkard, WP; Haefely, W; Keller, HH; Möhler, H; Richards, JG | 1 |
| Bovier, P; Broekkamp, CL; Lloyd, KG; Worms, P | 1 |
| Zetler, G | 1 |
| Morag, M; Myslobodsky, M | 1 |
| Griffiths, RR; Lukas, SE | 2 |
| Chapouthier, G; Grecksch, G; Prado de Carvalho, LP; Rossier, J | 1 |
| Cowen, PJ; Green, AR; Nutt, DJ | 1 |
| Chen Chow, S; Davies, LP; Johnston, GA; Skerritt, JH | 1 |
| Janiszewski, W; Schwarz, M; Sontag, KH; Turski, L | 1 |
| Koe, BK; Lebel, LA | 1 |
| Vellucci, SV; Webster, RA | 2 |
| Biggio, G; Concas, A; Salis, M; Serra, M | 1 |
| Khan, AR | 1 |
| Ashton, D | 1 |
| Biggio, G; Concas, A; Fanni, B; Mereu, G; Serra, M | 1 |
| Robertson, HA | 1 |
| Cronin, MJ; MacLeod, RM; O'Dell, SB; Schettini, G | 1 |
| Barbaz, BS; Bergen, KM; Bernard, PS; Boast, CA | 1 |
| Biggio, G | 1 |
| Corda, MG; Costa, E; Guidotti, A | 1 |
| Garattini, S; Mennini, T | 1 |
| Biggio, G; Mereu, G | 1 |
| File, SE; Green, AR; Nutt, DJ; Vincent, ND | 1 |
| De Robertis, E; Medina, JH; Novas, ML | 1 |
| Garrett, KM; Melchior, CL; Tabakoff, B | 1 |
| Barrett, JE; Mansbach, RS; Stanley, JA | 1 |
| Brick, I; Darragh, A; Kenny, M; Lambe, R; O'Boyle, C; Taffe, W | 1 |
| Lloyd, HG; Morgan, PF; Stone, TW | 2 |
| Camoratto, AM; Grandison, L | 1 |
| Childs, M; Simon, P; Soubrié, P; Thiébot, MH | 1 |
| Chapouthier, G; de Carvalho, LP; Grecksch, G; Rossier, J; Venault, P | 1 |
| Matlib, MA; Schwartz, A | 1 |
| Schwarz, M; Sontag, KH; Turski, L | 2 |
| Mokler, DJ; Rech, RH | 1 |
| Riives, ML; Robertson, HA | 1 |
| Elmesallamy, F; Emmett-Oglesby, M; Lal, H; Lewis, M; Spencer, D | 1 |
| Beani, L; Bianchi, C; Tanganelli, S | 1 |
| Minchin, MC; Nutt, DJ | 1 |
| Havemann, U; Kuschinsky, K; Turski, L | 1 |
| Kulkarni, SK; Mehta, AK | 1 |
| Follath, F; Kehl, O; Rapold, HJ; Ritz, R; Scollo-Lavizzari, G | 1 |
| Barzaghi, C; Marzanatti, M; Ongini, E | 1 |
| Berg, WK; Davis, M | 1 |
| Hamon, M; Simon, P; Soubrié, P; Thiébot, MH | 1 |
| Gaillard, JM; Laurian, S; Le, PK; Schöpf, J | 1 |
| Coleman, JB; Cox, C; Schuler, R; Wood, RW | 1 |
| Depaulis, A; Marescaux, C; Micheletti, G; Rumbach, L; Vergnes, M; Warter, JM | 1 |
| Emmett-Oglesby, MW; Lal, H; Lewis, MW; Spencer, DG | 1 |
| Clody, DE; Regan, BA | 1 |
| Cavalheiro, EA; Chapouthier, G; Dodd, RH; Grecksch, G; Prado de Carvalho, L; Rossier, J | 1 |
| McGonigal, P; Schofield, CN | 1 |
| Bonetti, EP; Cumin, R; Haefely, WE; Scherschlicht, R | 1 |
| Lee, EK; Ross, RJ; Walters, JR; Waszczak, BL | 1 |
| Brick, I; Darragh, A; Kenny, M; Lambe, R; O'Boyle, C; Taaffe, W | 1 |
| Albertson, TE; Bowyer, JF; Paule, MG | 1 |
| Cain, M; Cook, J; Paul, S; Schweri, M; Skolnick, P | 1 |
| Herling, S; Shannon, HE | 1 |
| Dodd, RH; Liston, DR; Potier, P; Rossier, J; Valin, A | 1 |
| Feldblum, S; Le Gal La Salle, G | 1 |
| Ekström, P; Grossmann, E; Meissl, H; Yáñez, J | 1 |
| Fink, H; Marsden, CA; Rex, A | 1 |
| Kaneto, H; Rahman, AF; Takahashi, M | 2 |
| Iwasaki, T; Nakagawa, Y | 1 |
| Jing, X; Sloan, JW; Wala, EP | 5 |
| Acri, JB; Witkin, JM; Wong, G | 1 |
| Jenck, F; Martin, JR; Moreau, JL | 1 |
| Adachi, M; Akatsu, M; Okuaki, A; Sinoda, M; Tase, C; Terashima, M; Watanabe, K | 1 |
| Fujigaki, T; Makita, T; Nakamura, H; Shibata, O; Sumikawa, K; Tsujita, T | 1 |
| Pham, Z; Reisner-Keller, LA | 1 |
| Breschi, MC; Cristofani, R; Giannaccini, G; Lucacchini, A; Martini, C; Martinotti, E; Scatizzi, R | 1 |
| Bonnafous, C; Bueno, L; Martinez, J | 1 |
| Pokk, P; Zharkovsky, A | 1 |
| Smith, VM | 1 |
| Bernik, MA; Gorenstein, C; Pompéia, S | 1 |
| Bonnafous, C; Bueno, L | 1 |
| Cartmell, SM; Mitchell, D | 2 |
| Brioni, JD; O'Neill, AB | 1 |
| Crabbe, JC; Keith, LD; Roberts, AJ | 1 |
| De Aguiar, JC; Graeff, FG; Guimarães, FS; Russo, AS | 1 |
| Miczek, KA; Vivian, JA | 1 |
| Dooley, DJ; Klamt, I | 1 |
| Breier, A; Hommer, D; Weingartner, H | 1 |
| Gardner, CR; Pringle, AK; Walker, RJ | 1 |
| Acevedo, X; Miranda, HF; Pesce, ME; Pinardi, G | 2 |
| Morel, E; Perrault, G; Sanger, DJ; Zivkovic, B | 1 |
| Kapetanovic, IM; Kupferberg, HJ; Torchin, CD | 1 |
| Laborit, H; Pierrefiche, G; Zerbib, R | 1 |
| Säfsten, B | 1 |
| Dajas, F; Medina, JH; Paladini, A; Viola, H; Wolfman, C | 1 |
| Melchior, CL; Ritzmann, RF | 1 |
| Andrews, N; File, SE | 1 |
| Biggio, G; Dazzi, L; Gessa, GL; Imperato, A; Serra, M | 1 |
| Fernández-Guasti, A; Saldívar-González, A | 1 |
| Biggio, G; Dazzi, L; Gessa, GL; Imperato, A; Obinu, MC | 2 |
| Hseu, SS; Hsing, CH; Lee, TY; Ng, KO; Tang, GJ | 1 |
| Cardinali, DP; Golombek, DA; Martini, M | 1 |
| McLachlan, RS; Sharpe, MD; Sprenger, H | 1 |
| Erskine, R; Langton, JA; Murphy, PJ | 1 |
| Laurie, DJ; Pratt, JA | 1 |
| Albertson, TE; Derlet, RW | 1 |
| Kubota, N; Shibata, T; Yokoyama, H | 1 |
| Hirakawa, K; Nihira, M; Uekusa, K; Uki, F | 1 |
| Hara, M; Ikemoto, Y; Kai, Y | 1 |
| Finder, RL; Moore, PA | 1 |
| Abbott, FV; Franklin, KB | 1 |
| Khan, RM; Soliman, MR | 1 |
| Lichtensteiger, W; Ramseier, H; Schlumpf, M | 1 |
| Cone, AM; Nadel, S; Sweeney, B | 1 |
| Aguglia, U; Gambardella, A; Oliveri, RL; Quattrone, A | 1 |
| Ishima, T; Iwasaki, T; Kimura, K; Nakagawa, Y | 1 |
| Arban, R; Costa, E; Ducić, I; Giusti, P; Guidotti, A; Puia, G; Walser, A | 1 |
| Katz, JL; Skolnick, P; Witkin, JM; Wong, G | 1 |
| Pericić, D; Pivac, N | 1 |
| Carlen, PL; Weiner, JL; Zhang, L | 1 |
| Saldeen, P; Stahl, MM; Vinge, E | 1 |
| Martin, WR; Sloan, JW; Wala, E | 1 |
| Jacobsen, D | 1 |
| Biggio, G; Dazzi, L; Maira, G; Motzo, C; Sanna, A; Serra, M | 1 |
| Funada, M; Misawa, M; Suzuki, T; Tsuda, M | 1 |
| Cepický, P; Pecená, M; Roth, Z; Sosnová, K; Stroufová, A | 1 |
| Fleishon, R; Geller, E; Rudick, V; Sorkine, P; Weinbroum, A | 1 |
| Contarino, A; Giusti, P; Lipartiti, M; Mariot, R; Zanotti, A | 1 |
| Meissl, H; Yáñez, J | 1 |
| Nader, MA; Woolverton, WL | 1 |
| Benson, GJ; Lemke, KA; Olson, WA; Thurmon, JC; Tranquilli, WJ | 1 |
| Bottlaender, M; Brouillet, E; Fuseau, C; Mazière, M; Schmid, L | 1 |
| Atsmon, J; Dagan, Y; Gavish, M; Laschiner, S; Laudon, M; Oaknin, S; Zisapel, N | 1 |
| Berardelli, A; Inghilleri, M; Manfredi, M; Marchetti, P | 1 |
| Hansen, HC; Jackson, HC; Judge, ME; Klitgaard, H; Kristiansen, M; Suzdak, PD; Swedberg, MD | 1 |
| Aguayo, LG; Cisternas, C; Pancetti, FC; Tapia, JC | 1 |
| Aguglia, U; De Sarro, GB; Gambardella, A; Oliveri, RL; Quattrone, A; Talerico, G; Zappia, M | 1 |
| Sloan, JW; Wala, EP | 1 |
| Neu, JM; Niles, LP; Tenn, CC | 1 |
| Matsumoto, K; Nguyen, MD; Nguyen, TN; Nguyen, TT; Watanabe, H; Yamasaki, K | 1 |
| Mimaki, Y; Miura, T; Sashida, Y; Yamada, K | 1 |
| al-Kawas, FH; Benjamin, SB; Fleischer, DE; Gallagher, J; Ginsberg, G; Kankaria, A; Lewis, JH; Nguyen, CC | 1 |
| Hatta, S; Saito, T; Takahata, N; Toki, S | 1 |
| Drewe, JA; Whittemore, ER; Woodward, RM; Yang, W | 1 |
| Close, JM; Finder, RL; Moore, PA | 1 |
| Herzog, CD; Stackman, RW; Walsh, TJ | 1 |
| Ai, J; Dekermendjian, K; Nielsen, M; Shan, R; Sterner, O; Witt, MR | 1 |
| Kulkarni, SK; Reddy, DS | 1 |
| Holtman, PH; Jing, X; Sloan, JW; Wala, EP | 1 |
| Matsumoto, K; Ojima, K; Watanabe, H | 1 |
| Nolan, PJ; Thompson, PJ; Tribe, AE; Williamson, BH | 1 |
| Bottlaender, M; Brouillet, E; Fournier, D; Fuseau, C; Mazière, M; Schmid, L | 1 |
| Lin, WC | 1 |
| Bubeck, B; Demisch, S; Sauer, H; Schröder, J | 1 |
| Bujas, M; Pericić, D | 1 |
| Baur, R; Buhr, A; Sigel, E | 1 |
| Kulkarni, SK; Roychoudhury, M | 1 |
| Biggio, G; Dazzi, L; Motzo, C; Porceddu, ML; Sanna, A; Serra, M | 1 |
| Gear, RW; Gordon, NC; Heller, PH; Levine, JD; Miaskowski, C; Paul, SM | 1 |
| Birnir, B; Curmi, JP; Eghbali, M; Gage, PW | 1 |
| Benke, D; Michel, C; Mohler, H | 1 |
| Jordan, S; Kramer, GL; Petty, F; Wu, J; Zukas, PK | 1 |
| Dohi, S; Furuya, K; Ishizawa, Y; Yamagishi, S | 1 |
| Furuya, A; Imamura, M; Kashimoto, S; Kumazawa, T; Nonaka, A | 1 |
| Camaris, C; Little, D | 1 |
| Da-Rocha, MA; Puech, AJ; Thiébot, MH | 1 |
| Fujita, S; Odano, I; Ohkubo, M; Takahashi, M | 1 |
| Kanaya, N; Nakae, Y; Namiki, A | 1 |
| Rodrigo, MR | 1 |
| Gevers, AM; Hendrickx, A; Macken, E; Rutgeerts, P | 1 |
| Celis, ME; Cremer, MC; De Barioglio, SR | 1 |
| Dixon, JC; Dixon, JJ; Speidel, BD | 1 |
| Gobaille, S; Maitre, M; Pain, L; Sandner, G; Schmidt-Mutter, C | 1 |
| Fernández-Guasti, A; López-Rubalcava, C | 1 |
| Kulkarni, SK; Shaji, AV | 1 |
| Costentin, J; De Mateos-Verchere, JG; Leprince, J; Tonon, MC; Vaudry, H | 1 |
| Cutilli, BJ; Saunders, W; Smith, BM | 1 |
| Bernik, MA; Gorenstein, C; Vieira Filho, AH | 1 |
| Holtman, JR; Jing, X; Milliken, B; Sloan, JW; Wala, E | 1 |
| Kuribara, H; Maruyama, Y; Stavinoha, WB | 1 |
| Gobert, J; Klitgaard, H; Matagne, A; Wülfert, E | 1 |
| Blanc, F; Butterworth, RF; Fabbro-Peray, P; Lavoie, J; Layrargues, GP; Mousseau, DD; Perney, P | 1 |
| Katukov, VIu; Lesnichuk, SA; Porodenko, NV; Severin, ES | 1 |
| Kawaguchi, M; Okubo, M | 1 |
| Bender, AS; Norenberg, MD | 1 |
| Honma, Y; Matsuzaki, T; Namiki, A; Tsujiguchi, N; Yamakage, M | 1 |
| Leeuwin, RS; van Wilgenburg, H; Zeegers, A | 1 |
| Ayhan, IH; Celik, T; Deniz, G; Palaoğlu, O; Uzbay, IT | 1 |
| Larson, JS; Lunn, JJ | 1 |
| Dalvi, A; Rodgers, RJ | 1 |
| Biscardi, R; Ford, K; Stock, H; Wilson, MA | 1 |
| Kitraki, E; Philippidis, H; Stylianopoulou, F; Tritos, N | 1 |
| García-Estañ, J; Hernández, J; Janvier, JJ | 1 |
| Kamei, J; Ohsawa, M | 2 |
| Aravind, MK; Kauffman, RE; Peters, JM; Simpson, P; Tolia, V | 1 |
| Contarino, A; Giusti, P; Lipartiti, M; Natolino, F; Zanotti, A | 1 |
| Rowlett, JK; Wilcox, KM; Woolverton, WL | 1 |
| Umezu, T | 1 |
| Avenet, P; Granger, P; Griebel, G; Letang, V; Perrault, G; Sanger, DJ; Schoemaker, H | 1 |
| France, CP; Gerak, LR | 2 |
| Holtman, JR; Jing, X; Sloan, JW; Wala, EP | 2 |
| Castro, JL; Ramirez, A; Ricci, D; Taira, CA | 1 |
| Moreira, EG; Nascimento, N; Rogero, JR; Vassilieff, VS | 1 |
| Kaneko, T; Kikusui, T; Tonohiro, T | 1 |
| Crowe, SF; Farkas, L | 1 |
| Bannister, AP; Hughes, DI; Pawelzik, H; Thomson, AM | 1 |
| Iida, Y; Kitano, H; Konishi, J; Magata, Y; Nishizawa, S; Saji, H; Shiozaki, T | 1 |
| Easterling, KW; Holtzman, SG; Plovnick, RM | 1 |
| Atack, JR; Bristow, L; Brown, N; Carling, RW; Castro, JL; Cook, G; Dawson, GR; Farrar, S; Ferris, P; Garrett, L; Howell, O; Macaulay, A; Marshall, G; McKernan, RM; Moore, KW; Myers, J; Ragan, CI; Reynolds, DS; Rosahl, TW; Street, LJ; Sur, C; Wafford, KA; Whiting, PJ | 1 |
| Nogueira, E; Vassilieff, VS | 1 |
| Kellogg, CK; Pleger, GL; Yao, J | 1 |
| Arias, C; Gómez, C; Martínez-Lomelí, I; Saldívar-González, A | 1 |
| Firestone, LL; Homanics, GE; Quinlan, JJ | 1 |
| Chojnacka-Wójcik, E; Przegaliński, E; Tatarczyńska, E | 1 |
| Ansaldo, MA; Fedele, E; Raiteri, M; Varnier, G | 1 |
| France, CP; Gerak, LR; Lelas, S | 1 |
| Kishi, E; Kuribara, H; Maruyama, Y | 1 |
| Akabas, MH; Williams, DB | 1 |
| Ebinger, G; Khan, GM; Michotte, Y; Smolders, I | 1 |
| Chojnacka-Wójcik, E; Klodzińska, A | 1 |
| Amin, J; Hadley, SH; Morris, KD; Walters, RJ | 1 |
| Fushiki, T; Hanai, K; Imaizumi, M; Inoue, K; Kuroda, K; Manabe, Y; Sako, N; Yamamoto, T | 1 |
| Parrott, RF; Vellucci, SV | 1 |
| Li, M; Rosenberg, HC; Szabo, A | 1 |
| Das, DG; James, M; Vijayalakshmi, G | 1 |
| Betti, L; Bistocchi, M; Giannaccini, G; Gori, M; Lucacchini, A | 1 |
| Chugun, A; Futamura, K; Hara, Y; Kobayashi, H; Kondo, H; Nishino, T; Ooshiro, S; Temma, K | 1 |
| Cook, JM; Ma, C; Miczek, KA; Rowlett, JK; Tornatzky, W | 1 |
| Béracochéa, D; Borde, N; Krazem, A | 1 |
| Depoortere, R; Jung, ME; Oglesby, MW | 1 |
| Paz, L; Peter, Y; Pick, CG; Weizman, R | 1 |
| Hellyer, PW; Kollias-Baker, C; Mama, KR; Shafford, HL; Wagner, AE | 1 |
| Arditti, J; Bourdon, JH; de Haro, L; Hayek-Lanthois, M; Iliadis, A; Valli, M | 1 |
| Kamei, J; Matsumiya, T; Ohsawa, M; Takeda, H; Tsuji, M | 1 |
| Biggio, F; Biggio, G; Busonero, F; Cagetti, E; Carta, M; Desole, MS; Follesa, P; Maciocco, E; Manca, A; Mancuso, L; Massa, F; Sanna, E | 1 |
| Abella, C; Hernandez, J; Vargas, ML | 1 |
| France, CP; Gerak, LR; McMahon, LR | 2 |
| Fuentes, T; Galindo, A; García Estañ, J; Hernández, J; Vargas, ML | 1 |
| Ago, Y; Baba, A; Koyama, Y; Matsuda, T; Murakami, C; Sakamoto, Y; Sakaue, M; Sowa, C | 1 |
| Carter, L; Cook, JM; France, CP; Gerak, LR; Ma, C; McMahon, LR | 1 |
| Vesanen, H | 1 |
| Luotio, K; Mattila, MA | 1 |
| Safo, P; Thompson, SA; Wafford, KA; Wheat, L; Whiting, PJ; Wingrove, PB | 1 |
| Mediratta, PK; Sharma, KK; Singh, S | 1 |
| Nemmani, KV; Ramarao, P | 1 |
| Agelink, MW; Andrich, J; Majewski, TB; Mueck-Weymann, M | 1 |
| Groenink, L; Maes, RA; Olivier, B; Oosting, RS; Pattij, T; van der Gugten, J | 1 |
| Griffey, KI; Schoepp, DD; Tizzano, JP | 1 |
| Elías, MM; Monasterolo, LA; Trumper, L | 1 |
| Andjelković, DS; Bokonjić, DR; Obradović, DI; Savić, MM; Stojilković, MP; Ugresić, ND | 1 |
| Allison, C; Claase, LA; Pratt, JA | 1 |
| Horne, WA; Kelly, BT; Larsen, RS; Loomis, MR; Sladky, KK; Stoskopf, MK | 1 |
| Aggarwal, P; Handa, R; Mohan, A; Mohan, C; Wali, JP | 1 |
| Hitosugi, N; Miyata, Y; Mizukami, S; Nagasaka, H; Nakamura, S; Ohno, R; Suzuki, M | 1 |
| Kawaguchi, M; Kujirai, M; Sawaki, K | 1 |
| France, CP; Jerussi, TP; McMahon, LR | 1 |
| Beani, L; Bianchi, C; Cavallini, S; Ferraro, L; Marino, S; Rodi, D; Siniscalchi, A | 1 |
| France, CP; McMahon, LR | 1 |
| Fachinelli, C; Ison, M; Rodríguez Echandía, EL | 1 |
| Bhandari, R; Mahajan, P; Mediratta, PK; Sharma, KK; Tewary, S | 1 |
| Kishore, K; Saraf, MK; Sharma, A; Singh, M; Thomas, KM | 1 |
| Chojnacka-Wójcik, E; Paluchowska, M; Wesołowska, A | 1 |
| Chebib, M; Davucheron, NL; Hall, BJ; Hanrahan, JR; Johnston, GA | 1 |
| Griffiths, RR; Kaminski, BJ; Lamb, RJ; Sannerud, CA; Weerts, EM | 1 |
| Basmadjian, G; Garrett, KM; Khan, IA; Schaneberg, BT; Seale, TW | 1 |
| Flaishon, R; Gavish, M; Leschiner, S; Rudick, V; Veenman, L; Weinbroum, AA | 1 |
| Hansen, SL; Sánchez, C; Sperling, BB | 1 |
| Hayashi, T; Kusumoto, G; Matsumoto, I; Miyata, Y; Murakami, Y; Nagasaka, H; Nakamura, S; Ohno, R; Suzuki, M; Terayama, K | 1 |
| Hosseinzadeh, H; Parvardeh, S | 1 |
| Keller, AF; Leroy, C; Nehlig, A; Poisbeau, P | 1 |
| Maruyama, K; Nakamura, S; Nishina, M; Suzuki, M | 1 |
| Chebib, M; Hall, BJ; Hanrahan, JR; Johnston, GA | 2 |
| Chojnacka-Wójcik, E; Cosford, ND; Klodzinska, A; Nowak, G; Pilc, A; Tatarczyńska, E | 1 |
| Hayashi, T; Kusumoto, G; Miyata, Y; Murakami, Y; Nagasaka, H; Nakamura, S; Nishida, M; Ohno, R; Sakamaki, H; Suzuki, M; Terayama, K | 1 |
| Griffiths, RR; Mintzer, MZ | 1 |
| Jembrek, MJ; Lazić, J; Pericić, D; Rajcan, I; Strac, DS | 1 |
| Hoebel, BG; Rada, P | 1 |
| Fukumitsu, N; Mori, Y; Ogi, S; Uchiyama, M | 2 |
| Chojnacka-Wójcik, E; Kłodzińska, A; Tatarczyńska, E | 1 |
| Choi, KB; Jeong, JH; Moon, NJ; Park, ES; Sohn, UD | 1 |
| Hosseinzadeh, H; Mansouri, MT; Nassiri-Asl, M; Parvardeh, S | 1 |
| Bernöster, K; Dost, R; Egerland, U; Langen, B; Rundfeldt, C; Unverferth, K | 1 |
| Ahadian, A; Faizi, M; Khojastehpoor, HR; Shafaghi, B; Shafiee, A; Tabatabai, SA; Zanganeh, V; Zarghi, A | 1 |
| Lazić, J; Pericić, D; Strac, DS | 1 |
| Carta, A; Chopde, CT; Kokare, DM; Patole, AM; Subhedar, NK | 1 |
| Fidecka, S; Listos, J; Malec, D | 1 |
| Ge, YX; Han, YF; Hu, NW; Hu, XD; Li, WM; Liu, XG; Zhang, HM; Zhang, T; Zhou, LJ | 1 |
| Conforti, P; Consolini, AE; Migliori, GN; Ragone, MI; Volonté, MG | 1 |
| Baqui, F; Bradshaw, CM; Hou, RH; Langley, RW; Samuels, ER; Scaife, JC; Szabadi, E | 1 |
| Cappell, MS | 1 |
| Hirano, S; Kamei, J; Miyata, S | 1 |
| Araki, H; Gomita, Y; Hashimoto, Y; Suemaru, K | 1 |
| Vesal, N; Zare, P | 1 |
| Kulkarni, SK; Kumar, A | 1 |
| Cook, JM; Duke, AN; Huang, S; Mattingly, BA; Platt, DM; Rowlett, JK; Yin, W | 1 |
| Besheer, J; Hodge, CW; Lepoutre, V; Mole, B | 1 |
| Groenink, L; Olivier, B; Oosting, R; Toth, M; Van Bogaert, M; van Oorschot, R | 1 |
| Otto, JF; Simeone, TA; White, HS; Wilcox, KS | 1 |
| Butterweck, V; Grundmann, O; Nakajima, J; Seo, S | 1 |
| Aragão, GF; Bandeira, PN; Carneiro, LM; Junior, AP; Lemos, TL; Viana, GS; Vieira, LC | 1 |
| Lamas, E; Pellón, R; Rodríguez, C; Ruíz, A | 1 |
| France, CP; Javors, MA; McMahon, LR | 1 |
| Frosini, M; Ricci, L; Sgaragli, G; Valoti, M | 1 |
| Jembrek, MJ; Pericić, D; Strac, DS; Vlainić, J | 1 |
| Cho, YW; Jang, CG; Jin, C; Jung, JW; Lee, JJ; Oh, TH; Ryu, JH; Yoon, BH | 1 |
| Nassiri-Asl, M; Shariati-Rad, S; Zamansoltani, F | 1 |
| Dhir, A; Kaushal, A; Kulkarni, SK | 1 |
| Dean, B; McLeod, MC; Sundram, S | 1 |
| Wesołowska, A | 1 |
| Ahonen, J; Olkkola, KT | 1 |
| Leal, L; Pinerua-Shuhaibar, L; Quintero, L; Silva, JA; Suarez-Roca, H | 1 |
| George, MS; Sury, MR | 1 |
| Heikkinen, AE; Korpi, ER; Möykkynen, TP | 1 |
| Butterweck, V; Grundmann, O; McGregor, GP; Wang, J | 1 |
| Keist, R; Pearce, RA; Rudolph, U; Zarnowska, ED | 1 |
| Bostwick, R; Chen, T; Huston, J; Knappenberger, K; Liu, J; Norris, T; Wood, M | 1 |
| Dordević, S; Jaćević, V; Jović-Stosić, J; Kilibarda, V; Potrebić, O; Segrt, Z; Vucinić, S; Vukcević-Perković, N | 1 |
| Douglas, SA; Furukawa, K; Hashiba, E; Hirota, K; Kawaguchi, Y; Kudo, M; Kudo, T; Kushikata, T; Ono, T; Yoshida, H | 1 |
| Butterweck, V; Grundmann, O; Kamata, K; Nakajima, J; Seo, S | 1 |
| Assreuy, AM; Bezerra, EH; Cavada, BS; de Sousa, FC; Lima, SR; Lobato, Rde F; Patrocínio, MC; Santi-Gadelha, T; Soares, PM; Vasconcelos, GS; Vasconcelos, SM | 1 |
| Evenden, J; Jonak, G; Ross, L; Zhou, J | 1 |
| Fukuyama, H; Hanakawa, T; Hashikawa, K; Ikeda, A; Iseki, K; Kawamoto, Y; Kihara, T; Mezaki, T; Shibasaki, H | 1 |
| Baur, R; Charon, S; Goeldner, M; Sigel, E; Tan, KR | 1 |
| Atack, JR; Cook, JM; Dawson, GR; Licata, SC; Platt, DM; Rowlett, JK; Rüedi-Bettschen, D; Van Linn, ML | 1 |
| Curley, MD; Ferrigno, M; Lovrincevic, MM; Lundgren, CE; Wylegala, J | 1 |
| Gangisetty, O; Reddy, DS | 1 |
| Acher, F; Brański, P; Pałucha-Poniewiera, A; Pilc, A; Stachowicz, K; Wierońska, JM | 1 |
| Antkowiak, B; Drexler, B; Hentschke, H; Zinser, S | 1 |
| Beyer, C; Emadi, F; Hadjiakhoondi, A; Sharifzadeh, M; Yassa, N | 1 |
| Cardenas, R; Quintero, L; Suarez-Roca, H | 1 |
| Chebib, M; Gavande, N; Hanrahan, JR; Johnston, GA; Karim, N; Wellendorph, P | 1 |
| Cook, JM; Divljaković, J; Milić, M; Rallapalli, S; Savić, MM; Timić, T; van Linn, ML | 1 |
| Costa, JP; de Almeida, AA; de Carvalho, RB; de Freitas, RM; de Sousa, DP | 1 |
| Baldisserotto, B; Barros, FM; Bürger, ME; Caron, BO; Heinzmann, BM; Heldwein, CG; Mallmann, CA; Reckziegel, P; Schmidt, D; Silva, LL | 1 |
| Chen, CR; Huang, ZL; Luo, YJ; Qu, WM; Urade, Y; Zhou, XZ | 1 |
| Prather, JF | 1 |
| Cook, JM; Groenink, L; Hansen, HH; Mirza, NR; Nielsen, EØ; Olivier, B; van Oorschot, R; Vinkers, CH | 1 |
| Furuya, H; Inoue, S; Iwata, M; Kawaguchi, M | 1 |
| Cook, JM; Divljaković, J; Milić, M; Namjoshi, OA; Savić, MM; Timić, T; Tiruveedhula, VV | 1 |
| Brito, GA; Cavalheiro, EA; da Costa, MA; da Cruz, GM; da Graça Naffah-Mazzacoratti, M; de Andrade, GM; de Barros Viana, GS; Felipe, CF; Leal, LK; Menezes, ML; Scorza, FA; Tavares, AF | 1 |
| Cho, S; Han, D; Jin, YH; Jin, Z; Kim, IH; Kim, S | 1 |
| Farbood, Y; Mansouri, MT; Mashak, A; Naghizadeh, B; Sarkaki, A; Soltani, M | 1 |
| de Almeida, AA; de Carvalho, RB; de Freitas, RM; de Sousa, DP; Silva, OA | 1 |
| Cho, NC; Cho, S; Han, JK; Huang, ZL; Jin, YH; Kim, J; Kim, JS; Kim, S; Pae, AN; Shimizu, M; Takata, Y; Urade, Y; Yang, H; Yoon, M | 1 |
| Baldisserotto, B; Bürger, ME; Flores, ÉM; Gai, EZ; Heinzmann, BM; Heldwein, CG; Parodi, TV; Roman, C; Silva, Lde L | 1 |
| Gruca, P; Lason-Tyburkiewicz, M; Litwa, E; Papp, M; Willner, P | 1 |
| Asadi-Shekaari, M; Eslami, A; Joukar, S; Kalantaripour, T | 1 |
| Bäckström, T; Helström, L; Möller, AT; Nyberg, S; Söndergaard, HP | 1 |
| Baur, R; Maldifassi, MC; Middendorp, SJ; Sigel, E | 1 |
| Banks, ML; Shelton, KL; Tracy, ME | 1 |
| Baldisserotto, B; Bürger, ME; Garlet, QI; Gressler, LT; Heinzmann, BM; Pires, LC; Silva, DT; Spall, S | 1 |
| Bonnefoi, F; Bouillot, C; Liger, F; Zimmer, L | 1 |
| Chen, SL; Liu, XG; Wei, XH; Zang, Y; Zheng, WH | 1 |
| Djordjević, S; Jović-Stosić, J; Kilibarda, V; Perković-Vukcević, N; Segrt, Z | 1 |
| Djordjević, S; Ercegović, GV; Segrt, Z; Stosić, JJ; Vukcević, NP | 1 |
| Absalom, NL; Chebib, M; Christensen, ET; Chua, HC; Hartiadi, LY; Hoestgaard-Jensen, K; Jensen, AA; Ramzan, I | 1 |
| Beckman, D; Blaha, CD; Boschen, SL; Da Cunha, C; Ferreira, ST; Fiorenza, AM; Gomez-A, A; Lee, K; Sugi, AH | 1 |
| Fernández-Guasti, A; González-Trujano, ME; Hernandez-Leon, A | 1 |
| Deng, S; Ding, J; Fan, HR; Ge, WH; Huang, C; Li, F; Li, WG; Liu, YM; Xu, TL; Zhu, T | 1 |
| Erfanparast, A; Henareh-Chareh, F; Tamaddonfard, E | 1 |
| Brodnik, ZD; España, RA; Oleson, EB; Pultorak, KJ; Rakowski, DR; Sambells, AT; Schelp, SA | 1 |
| Barbosa-Filho, JM; Chaves, EMC; Dantas, LP; Honório-Júnior, JER; Lúcio, ASSC; Monteiro, VS; Nonato, DTT; Patrocínio, MCA; Sousa, CNS; Vasconcelos, SMM; Viana, GSB | 1 |
| Christian, CA; Courtney, CD | 1 |
| Chen, JG; Deng, Q; Gao, SQ; Hu, ZL; Liu, WH; Long, LH; Lu, JJ; Nie, TL; Shen, ZC; Wang, F; Wu, PF; Xia, ZX; Yao, XP; Zhang, SQ; Zheng, HL | 1 |
| Das, N; Ganeshpurkar, A; Gupta, SK; Krishnamurthy, S; Kumar, D; Singh, R; Singh, SK | 1 |
| Clodfelder-Miller, B; McNaught, J; Nelson, DE; Ness, TJ; Su, X | 1 |
| Gharpure, A; Hibbs, RE; Howard, RJ; Kim, JJ; Lindahl, E; Noviello, CM; Teng, J; Walsh, RM; Zhu, S; Zhuang, Y | 1 |
| Marjanović, DS; Nikolic, K; Perdih, A; Stevanovic, S; Trailović, SM; Zdravković, N | 1 |
| Amundarain, MJ; Caffarena, ER; Costabel, MD | 1 |
| Acquas, E; Bassareo, V; Cottiglia, F; Kasture, SB; Maccioni, E; Maccioni, R; Sanna, E; Talani, G | 1 |
| Esumi, S; Izushi, Y; Kitamura, Y; Matsumoto, D; Noda, Y; Sendo, T; Ushio, S; Wada, Y | 1 |
| Behzad, S; Faizi, M; Jahani, R; Saffariha, M; Toufan Tabrizi, N | 1 |
| Cao, Y; Lian, J; Ma, Y; Muheyati, A; Su, R; Wang, N; Yu, G; Yuan, S; Zhang, S | 1 |
| Basso-Hulse, G; Bennett, KS; Gallo, AT; Hulse, GK; MacDonald, T | 1 |
| Basso-Hulse, G; Gallo, AT; Hulse, GK; MacDonald, T | 1 |
| Ahmed, T; Al-Khafaji, K; Araújo, IM; Bappi, MH; Coutinho, HDM; de Andrade, EM; Hanif, MA; Hossain, R; Islam, MS; Islam, MT; Khan, RA; Kowalska, G; Kowalski, R; Rahaman, MM; Sarkar, C | 1 |
17 review(s) available for flumazenil and diazepam
| Article | Year |
|---|---|
Ion channels as therapeutic targets: a drug discovery perspective.
Topics: Drug Discovery; Humans; Ion Channels; Models, Molecular; Phylogeny | 2013 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
The benzodiazepines: anxiolytic and withdrawal effects.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Carbolines; Diazepam; Disease Models, Animal; Ethanol; Flumazenil; Humans; Rats; Receptors, GABA-A; Substance Withdrawal Syndrome; Verapamil | 1991 |
Behavioural pharmacology of food, water and salt intake in relation to drug actions at benzodiazepine receptors.
Topics: Animals; Anti-Anxiety Agents; Appetite; Appetite Depressants; Benzodiazepines; Benzodiazepinones; Carbolines; Chlordiazepoxide; Chlorides; Choice Behavior; Diazepam; Drinking Behavior; Feeding Behavior; Flumazenil; Food Deprivation; Food Preferences; gamma-Aminobutyric Acid; Ion Channels; Midazolam; Picrotoxin; Punishment; Pyrazoles; Receptors, GABA-A; Satiation; Sodium Chloride; Species Specificity | 1985 |
Flumazenil: US clinical pharmacology studies.
Topics: Adult; Diazepam; Double-Blind Method; Drug Interactions; Female; Flumazenil; Humans; Lorazepam; Male; Memory; Receptors, GABA-A; Triazolam | 1988 |
Time course for development of benzodiazepine tolerance and physical dependence.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Diazepam; Drug Tolerance; Flumazenil; Flurazepam; Humans; Hypnotics and Sedatives; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1985 |
The role of adenosine in the central actions of the benzodiazepines.
Topics: Adenosine; Animals; Anti-Anxiety Agents; Arousal; Benzodiazepinones; Brain; Carbolines; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Neural Inhibition; Neurons; Purkinje Cells; Rats; Receptors, GABA-A | 1988 |
[Drug activation of GABAergic transmission in the central nervous system: benzodiazepines and GABAergic agonists].
Topics: Animals; Benzodiazepines; Benzodiazepinones; Brain; Carbolines; Chemical Phenomena; Chemistry; Cyclic GMP; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Humans; Receptors, GABA-A; Synaptic Transmission; Valproic Acid | 1985 |
Pharmacokinetics and clinical use of flumazenil (Ro 15-1788).
Topics: Anesthesia; Benzodiazepines; Diazepam; Flumazenil; Humans; Injections, Intravenous; Poisoning | 1988 |
Adenosine's role in the central actions of the benzodiazepines.
Topics: Adenosine; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepinones; Brain; Cats; Cell Line; Cerebral Cortex; Diazepam; Flumazenil; Rats; Synaptosomes; Thioinosine | 1984 |
The neuropharmacology of various diazepam antagonists.
Topics: Animals; Benzodiazepinones; Caffeine; Carbolines; Diazepam; Flumazenil; Humans; Physostigmine; Pyrazoles; Receptors, Cell Surface; Receptors, GABA-A; Theophylline | 1983 |
Antagonists to the benzodiazepines.
Topics: Anesthesia, Dental; Benzodiazepines; Benzodiazepinones; Diazepam; Flumazenil; Humans | 1984 |
Benzodiazepines for intravenous conscious sedation: agonists and antagonists.
Topics: Anesthesia, Dental; Benzodiazepines; Conscious Sedation; Diazepam; Flumazenil; Humans; Injections, Intravenous; Lorazepam; Midazolam | 1993 |
Comparing drugs for short-term sedation.
Topics: Anesthesia; Benzodiazepines; Conscious Sedation; Diazepam; Flumazenil; Humans; Lorazepam; Midazolam; Pain; Propofol | 1994 |
[Parenteral use of benzodiazepines in dentistry in order to reduce stress in adult patients].
Topics: Adult; Anesthetics; Antidotes; Conscious Sedation; Dental Care; Diazepam; Flumazenil; Humans; Midazolam; Middle Aged; Monitoring, Physiologic; Oximetry; Premedication; Stress, Psychological | 1996 |
Sedation and analgesia for gastrointestinal endoscopy during pregnancy.
Topics: Analgesia; Analgesics, Opioid; Cholangiopancreatography, Endoscopic Retrograde; Conscious Sedation; Diazepam; Endoscopy, Gastrointestinal; Female; Fentanyl; Fetus; Flumazenil; Humans; Hypnotics and Sedatives; Ketamine; Lidocaine; Meperidine; Naloxone; Pregnancy; Propofol; Risk Assessment; Triage | 2006 |
Midazolam and other benzodiazepines.
Topics: Anesthetics, Intravenous; Animals; Benzodiazepines; Biotransformation; Central Nervous System; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Flumazenil; Humans; Lorazepam; Midazolam; Molecular Structure; Receptors, GABA-A; Structure-Activity Relationship | 2008 |
38 trial(s) available for flumazenil and diazepam
| Article | Year |
|---|---|
The effect of intravenous flumazenil on interictal electroencephalographic epileptic activity: results of a placebo-controlled study.
Topics: Adult; Anticonvulsants; Brain; Diazepam; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electroencephalography; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; Evoked Potentials; Female; Flumazenil; Humans; Infusions, Intravenous; Male; Middle Aged; Receptors, GABA-A; Single-Blind Method | 1991 |
[The sequence chlorodimethyldiazepam/anexate in the pharmacologic hypnosis of patients undergoing peripheral anesthesia in orthopedics and traumatology].
Topics: Aged; Anesthesia, Local; Diazepam; Double-Blind Method; Female; Flumazenil; Humans; Hypnosis, Anesthetic; Male; Middle Aged; Orthopedics; Wounds and Injuries | 1991 |
The effect of the benzodiazepine antagonist flumazenil on the sequels of diazepam given before upper gastrointestinal endoscopy. A double-blind randomized trial.
Topics: Adult; Aged; Analysis of Variance; Conscious Sedation; Diazepam; Double-Blind Method; Endoscopy, Digestive System; Female; Flumazenil; Humans; Male; Middle Aged; Psychomotor Performance; Time Factors | 1991 |
Nociceptive quality of the orbicularis oculi reflexes as evaluated by distinct opiate- and benzodiazepine-induced changes in man.
Topics: Adult; Blinking; Diazepam; Electric Stimulation; Electromyography; Fentanyl; Flumazenil; Humans; Naloxone; Nociceptors; Placebos | 1991 |
[Beta activation following the intravenous administration of benzodiazepines and the specific antagonist flumazenil (Ro 15-1788)].
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Beta Rhythm; Diazepam; Dose-Response Relationship, Drug; Electroencephalography; Flumazenil; Flunitrazepam; Humans; Injections, Intravenous; Lorazepam; Male; Midazolam; Prospective Studies; Randomized Controlled Trials as Topic; Stimulation, Chemical | 1990 |
Reversal of benzodiazepine sedation with the antagonist flumazenil.
Topics: Adolescent; Adult; Aged; Ambulatory Care; Anesthesia Recovery Period; Anesthesia, Intravenous; Benzodiazepines; Cognition; Diazepam; Double-Blind Method; Female; Flumazenil; Gastroscopy; Headache; Humans; Male; Memory; Midazolam; Middle Aged; Psychomotor Performance | 1991 |
Flumazenil used for antagonizing the central effects of midazolam and diazepam in outpatients.
Topics: Adult; Aged; Ambulatory Care; Clinical Trials as Topic; Diazepam; Double-Blind Method; Female; Flumazenil; Gastroscopy; Humans; Male; Midazolam; Middle Aged; Random Allocation | 1989 |
Time course of antagonism of sedative and amnesic effects of diazepam by flumazenil.
Topics: Adult; Arousal; Clinical Trials as Topic; Diazepam; Double-Blind Method; Female; Flumazenil; Humans; Male; Memory; Molar, Third; Random Allocation; Time Factors; Tooth, Impacted | 1989 |
Antagonism of diazepam sedation by flumazenil.
Topics: Aged; Aged, 80 and over; Alfentanil; Anesthesia, General; Carbon Dioxide; Diazepam; Double-Blind Method; Flumazenil; Humans; Middle Aged; Nitrous Oxide; Oxygen; Randomized Controlled Trials as Topic; Wakefulness | 1989 |
Fentanyl-midazolam-flumazenil anesthesia for induced abortion.
Topics: Abortion, Induced; Adolescent; Adult; Ambulatory Care Facilities; Anesthesia Recovery Period; Diazepam; Drug Therapy, Combination; Female; Fentanyl; Flumazenil; Humans; Ketamine; Meperidine; Midazolam; Pain Measurement; Pregnancy; Random Allocation | 1989 |
Flumazenil used in the antagonizing of diazepam and midazolam sedation in out-patients undergoing gastroscopy.
Topics: Adolescent; Adult; Aged; Diazepam; Double-Blind Method; Flumazenil; Gastroscopy; Humans; Midazolam; Middle Aged; Outpatients; Random Allocation; Receptors, GABA-A; Sleep | 1988 |
Flumazenil: US clinical pharmacology studies.
Topics: Adult; Diazepam; Double-Blind Method; Drug Interactions; Female; Flumazenil; Humans; Lorazepam; Male; Memory; Receptors, GABA-A; Triazolam | 1988 |
Benzodiazepine antagonist Ro 15-1788. Antagonism of diazepam sedation in outpatients undergoing gastroscopy.
Topics: Adolescent; Adult; Aged; Amnesia; Clinical Trials as Topic; Diazepam; Double-Blind Method; Female; Flumazenil; Gastroscopy; Humans; Hypnotics and Sedatives; Male; Middle Aged; Time Factors | 1986 |
Antagonism of diazepam-induced sedative effects by Ro15-1788 in patients after surgery under lumbar epidural block. A double-blind placebo-controlled investigation of efficacy and safety.
Topics: Adult; Aged; Amnesia; Anesthesia, Epidural; Clinical Trials as Topic; Diazepam; Double-Blind Method; Emotions; Female; Flumazenil; Humans; Hypnotics and Sedatives; Male; Middle Aged; Psychomotor Performance; Random Allocation | 1987 |
[Clinical evaluation of flumazenil (Anexate) on the recovery parameters following the administration of 3 benzodiazepines (flunitrazepam, midazolam or diazepam].
Topics: Adult; Aged; Analgesics; Anesthesia Recovery Period; Anesthesia, General; Benzodiazepines; Diazepam; Drug Evaluation; Female; Flumazenil; Flunitrazepam; Humans; Male; Midazolam; Middle Aged; Postoperative Period; Prospective Studies; Random Allocation; Respiration | 1987 |
Clinical use of flumazenil (Ro 15-1788) after endoscopic procedures.
Topics: Adult; Aged; Clinical Trials as Topic; Diazepam; Double-Blind Method; Endoscopy; Female; Flumazenil; Humans; Male; Middle Aged; Random Allocation | 1988 |
Ro 15-1788 antagonizes the effects of diazepam in man without affecting its bioavailability.
Topics: Adolescent; Adult; Benzodiazepines; Benzodiazepinones; Biological Availability; Clinical Trials as Topic; Diazepam; Double-Blind Method; Flumazenil; Humans; Learning; Male; Memory; Psychomotor Performance; Random Allocation; Time Factors | 1983 |
RO 15-1788 antagonises the central effects of diazepam in man without altering diazepam bioavailability.
Topics: Adult; Benzodiazepinones; Biological Availability; Diazepam; Double-Blind Method; Emotions; Flumazenil; Humans; Male; Psychomotor Performance | 1982 |
[The effect of flumazenil in reversing midazolam, flunitrazepam or diazepam].
Topics: Adolescent; Adult; Anesthesia Recovery Period; Anesthesia, Epidural; Anesthesia, Spinal; Diazepam; Female; Flumazenil; Flunitrazepam; Hemodynamics; Humans; Male; Midazolam; Middle Aged; Respiration | 1995 |
Differential acute psychomotor and cognitive effects of diazepam on long-term benzodiazepine users.
Topics: Adult; Anxiety Disorders; Cognition; Depressive Disorder; Diazepam; Dose-Response Relationship, Drug; Double-Blind Method; Drug Tolerance; Female; Flumazenil; Humans; Injections, Intravenous; Long-Term Care; Male; Mental Recall; Middle Aged; Neuropsychological Tests; Personality Inventory; Psychomotor Performance; Receptors, GABA-A; Substance Withdrawal Syndrome; Substance-Related Disorders | 1994 |
Dissociation of benzodiazepine-induced amnesia from sedation by flumazenil pretreatment.
Topics: Adult; Amnesia; Attention; Cross-Over Studies; Diazepam; Double-Blind Method; Flumazenil; Humans; Hypnotics and Sedatives; Male; Memory, Short-Term; Mental Recall | 1993 |
The effect of intravenously administered diazepam, midazolam and flumazenil on the sensitivity of upper airway reflexes.
Topics: Adult; Ammonia; Diazepam; Double-Blind Method; Flumazenil; Gagging; Humans; Injections, Intravenous; Male; Midazolam; Reaction Time; Time Factors | 1994 |
Ability of flumazenil, butorphanol, and naloxone to reverse the anesthetic effects of oxymorphone-diazepam in dogs.
Topics: Adjuvants, Anesthesia; Anesthetics, Combined; Animals; Butorphanol; Cross-Over Studies; Diazepam; Dogs; Drug Combinations; Female; Flumazenil; Male; Naloxone; Narcotic Antagonists; Oxymorphone; Time Factors | 1996 |
Flumazenil reversal of psychomotor impairment due to midazolam or diazepam for conscious sedation for upper endoscopy.
Topics: Adult; Aged; Aged, 80 and over; Akathisia, Drug-Induced; Anesthetics, Intravenous; Antidotes; Chi-Square Distribution; Conscious Sedation; Diazepam; Duodenoscopy; Esophagoscopy; Female; Flumazenil; Gastroscopy; Humans; Male; Midazolam; Middle Aged; Treatment Outcome | 1996 |
Flumazenil reversal of conscious sedation induced with intravenous fentanyl and diazepam.
Topics: Adult; Analysis of Variance; Anesthesia Recovery Period; Anesthesia, Dental; Anesthetics, Intravenous; Conscious Sedation; Diazepam; Double-Blind Method; Female; Fentanyl; Flumazenil; GABA Antagonists; Humans; Hypnotics and Sedatives; Male; Middle Aged | 1995 |
A placebo controlled study of flumazenil in bronchoscopic procedures.
Topics: Adolescent; Aged; Anti-Anxiety Agents; Antidotes; Bronchoscopy; Conscious Sedation; Diazepam; Double-Blind Method; Female; Flumazenil; Hemodynamics; Humans; Injections, Intravenous; Male; Middle Aged; Psychomotor Performance | 1997 |
Benzodiazepine mediated antagonism of opioid analgesia.
Topics: Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Anxiety Agents; Diazepam; Double-Blind Method; Drug Synergism; Female; Flumazenil; GABA Modulators; Humans; Ibuprofen; Injections, Intravenous; Male; Molar, Third; Morphine; Pain Measurement; Pain, Postoperative; Premedication; Receptors, GABA-A; Tooth Extraction | 1997 |
Midazolam versus diazepam in lipid emulsion as conscious sedation for colonoscopy with or without reversal of sedation with flumazenil.
Topics: Adolescent; Adult; Analysis of Variance; Anesthetics, Combined; Anesthetics, Intravenous; Antidotes; Colonoscopy; Conscious Sedation; Diazepam; Double-Blind Method; Fat Emulsions, Intravenous; Female; Flumazenil; Humans; Logistic Models; Male; Midazolam; Middle Aged; Pain; Pain Measurement; Patient Satisfaction | 1998 |
Stressful reactions and panic attacks induced by flumazenil in chronic benzodiazepine users.
Topics: Adult; Anti-Anxiety Agents; Arousal; Diazepam; Double-Blind Method; Female; Flumazenil; GABA Modulators; Humans; Infusions, Intravenous; Male; Middle Aged; Panic; Panic Disorder; Substance-Related Disorders | 1998 |
Flumazenil in children after esophagogastroduodenoscopy.
Topics: Adolescent; Analgesics, Opioid; Anesthesia Recovery Period; Benzodiazepines; Child; Conscious Sedation; Diazepam; Double-Blind Method; Endoscopy, Gastrointestinal; Esophagoscopy; Female; Flumazenil; Humans; Hypnotics and Sedatives; Male; Meperidine; Prospective Studies | 1999 |
Short-term effects of intravenous benzodiazepines on autonomic neurocardiac regulation in humans: a comparison between midazolam, diazepam, and lorazepam.
Topics: Adult; Autonomic Nervous System; Benzodiazepines; Diazepam; Female; Flumazenil; Heart; Heart Rate; Humans; Injections, Intravenous; Lorazepam; Male; Midazolam; Middle Aged; Preanesthetic Medication; Prospective Studies | 2002 |
Flumazenil-precipitated withdrawal in healthy volunteers following repeated diazepam exposure.
Topics: Administration, Oral; Adult; Blood Pressure; Diazepam; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Flumazenil; GABA Modulators; Humans; Hypnotics and Sedatives; Injections, Intravenous; Male; Skin Temperature; Substance Withdrawal Syndrome; Substance-Related Disorders | 2005 |
Diazepam-induced disruption of classically-conditioned fear-potentiation of late-latency auditory evoked potentials is prevented by flumazenil given before, but not after, CS/US pairing.
Topics: Adult; Anti-Anxiety Agents; Association Learning; Conditioning, Classical; Diazepam; Double-Blind Method; Drug Administration Schedule; Electroshock; Evoked Potentials, Auditory; Evoked Potentials, Somatosensory; Fear; Flumazenil; GABA Antagonists; Humans; Male; Photic Stimulation; Reaction Time; Receptors, GABA-A; Reference Values; Reflex, Startle; Time Factors | 2007 |
Clinical evaluation of intranasal benzodiazepines, alpha-agonists and their antagonists in canaries.
Topics: Administration, Intranasal; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthesia; Animals; Behavior, Animal; Benzodiazepines; Canaries; Diazepam; Drug Therapy, Combination; Female; Flumazenil; Hypnotics and Sedatives; Imidazoles; Male; Midazolam; Prospective Studies; Xylazine; Yohimbine | 2006 |
Extending submarine crew survival by reducing CO2 production with quickly reversible sedation.
Topics: Acceleration; Adult; Analysis of Variance; Antidotes; Carbon Dioxide; Cognition; Diazepam; Flumazenil; GABA Modulators; Health Status Indicators; Humans; Hypnotics and Sedatives; Male; Oxygen Consumption; Respiration; Submarine Medicine; Time Factors; Young Adult | 2010 |
Rapid and reliable sedation induced by diazepam and antagonized by flumazenil in zebra finches (Taeniopygia guttata).
Topics: Anesthesia Recovery Period; Animals; Antidotes; Consciousness; Diazepam; Dose-Response Relationship, Drug; Female; Finches; Flumazenil; Hypnotics and Sedatives; Male | 2012 |
A double-blind randomised crossover trial of low-dose flumazenil for benzodiazepine withdrawal: A proof of concept.
Topics: Benzodiazepines; Cross-Over Studies; Diazepam; Double-Blind Method; Flumazenil; GABA-A Receptor Antagonists; Humans; Inactivation, Metabolic; Pilot Projects; Receptors, GABA-A; Substance Withdrawal Syndrome | 2022 |
Outcomes of patients treated with low-dose flumazenil for benzodiazepine detoxification: A description of 26 participants.
Topics: Benzodiazepines; Diazepam; Flumazenil; Humans; Substance Withdrawal Syndrome | 2022 |
679 other study(ies) available for flumazenil and diazepam
| Article | Year |
|---|---|
Benzodiazepine receptor affinity and interaction of some N-(indol-3-ylglyoxylyl)amine derivatives.
Topics: Animals; Anticonvulsants; Binding, Competitive; Cattle; Cell Membrane; Cerebral Cortex; Convulsants; Dopamine; Flunitrazepam; Indoles; Mice; Molecular Structure; Receptors, GABA-A; Structure-Activity Relationship; Tryptamines; Tyramine | 1992 |
Tricyclic heteroaromatic systems. [1]benzopyranopyrrol-4-ones and [1]benzopyrano-1,2,3-triazol-4-ones as benzodiazepine receptor ligands. Synthesis and structure-activity relationships.
Topics: Animals; Azoles; Benzopyrans; Cattle; Chemical Phenomena; Chemistry; Dibenzazepines; Ligands; Pyrroles; Receptors, GABA-A; Structure-Activity Relationship | 1990 |
Novel benzodiazepine receptor partial agonists: oxadiazolylimidazobenzodiazepines.
Topics: Animals; Benzodiazepines; Cell Membrane; Cerebral Cortex; Models, Molecular; Molecular Conformation; Molecular Structure; Oxadiazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Structure-Activity Relationship; X-Ray Diffraction | 1989 |
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Benzodiazepine receptor binding and anticonflict activity in a series of 3,6-disubstituted pyridazino[4,3-c]isoquinolines devoid of anticonvulsant properties.
Topics: Animals; Binding, Competitive; Chemical Phenomena; Chemistry; Conflict, Psychological; Diazepam; Isoquinolines; Male; Mice; Pyridazines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Structure-Activity Relationship | 1985 |
Four amino acid exchanges convert a diazepam-insensitive, inverse agonist-preferring GABAA receptor into a diazepam-preferring GABAA receptor.
Topics: Amino Acid Sequence; Azides; Base Sequence; Benzodiazepines; Binding Sites; Diazepam; GABA Agonists; Humans; Molecular Sequence Data; Mutation; Receptors, GABA-A; Structure-Activity Relationship | 1994 |
Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepine receptors.
Topics: Animals; Benzodiazepines; Binding Sites; Brain; Esters; Imidazoles; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1993 |
Structure-activity relationship studies at the benzodiazepine receptor (BZR): a comparison of the substitutent effects of pyrazoloquinolinone analogs.
Topics: Animals; Brain; In Vitro Techniques; Pyrazoles; Quinolones; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Solubility; Structure-Activity Relationship | 1993 |
Synthesis and binding activity of some pyrazolo[1,5-c]quinazolines as tools to verify an optional binding site of a benzodiazepine receptor ligand.
Topics: Animals; Binding Sites; Flunitrazepam; Hydrogen Bonding; Male; Pyrazoles; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Structure-Activity Relationship; Tritium | 1996 |
N'-Phenylindol-3-ylglyoxylohydrazide derivatives: synthesis, structure-activity relationships, molecular modeling studies, and pharmacological action on brain benzodiazepine receptors.
Topics: Animals; Anticonvulsants; Binding, Competitive; Brain; Cattle; Cerebral Cortex; Convulsants; Diazepam; Flumazenil; GABA Modulators; Glyoxylates; Hydrazines; In Vitro Techniques; Indoles; Ligands; Mice; Models, Molecular; Molecular Conformation; Receptors, GABA-A; Seizures; Structure-Activity Relationship | 1998 |
Benzodiazepine receptor ligands. 4. Synthesis and pharmacological evaluation of 3-heteroaryl-8-chloropyrazolo[5,1-c][1,2,4] benzotriazine 5-oxides.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Cattle; Cerebral Cortex; Cyclic N-Oxides; In Vitro Techniques; Ligands; Male; Mice; Muscle Relaxants, Central; Radioligand Assay; Receptors, GABA-A; Triazines | 1999 |
Structure-activity relationships and molecular modeling analysis of flavonoids binding to the benzodiazepine site of the rat brain GABA(A) receptor complex.
Topics: Animals; Binding Sites; Brain; Flavonoids; In Vitro Techniques; Male; Models, Molecular; Molecular Conformation; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A; Reproducibility of Results; Structure-Activity Relationship | 1999 |
Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach.
Topics: Animals; Benzodiazepines; Carbolines; Cell Line; Columbidae; Conditioning, Operant; Crystallography, X-Ray; Humans; Indoles; Ligands; Male; Models, Molecular; Pyrimidines; Quinolones; Radioligand Assay; Receptors, GABA-A; Saimiri; Stereoisomerism; Structure-Activity Relationship | 2000 |
3-Aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: tricyclic heteroaromatic derivatives as a new class of benzodiazepine receptor ligands.
Topics: Animals; Anticonvulsants; Benzimidazoles; Brain; Cattle; Convulsants; Diazepam; Flumazenil; GABA Modulators; In Vitro Techniques; Ligands; Membranes; Mice; Models, Molecular; Radioligand Assay; Receptors, GABA-A | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Benzodiazepine receptor ligands. 7. Synthesis and pharmacological evaluation of new 3-esters of the 8-chloropyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide. 3-(2-Thienylmethoxycarbonyl) derivative: an anxioselective agent in rodents.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Avoidance Learning; Cell Line; Cerebral Cortex; Cyclic N-Oxides; Drug Interactions; Ethanol; Exploratory Behavior; GABA Agents; Heterocyclic Compounds, 3-Ring; Humans; In Vitro Techniques; Ligands; Memory; Mice; Motor Skills; Neuromuscular Agents; Rats; Receptors, GABA-A; Seizures; Sleep; Structure-Activity Relationship; Triazines | 2002 |
An anxiolytic-like effect of Ginkgo biloba extract and its constituent, ginkgolide-A, in mice.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Caffeine; Cyclopentanes; Diazepam; Diterpenes; Dose-Response Relationship, Drug; Furans; Ginkgo biloba; Ginkgolides; Lactones; Male; Maze Learning; Mice; Mice, Inbred Strains; Molecular Structure; Motor Activity; Phenobarbital; Plant Extracts; Plants, Medicinal; Sleep | 2003 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
High affinity central benzodiazepine receptor ligands: synthesis and biological evaluation of a series of phenyltriazolobenzotriazindione derivatives.
Topics: Animals; Binding, Competitive; Brain; Cattle; Cell Line; Chlorides; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Humans; In Vitro Techniques; Models, Molecular; Protein Isoforms; Radioligand Assay; Rats; Recombinant Proteins; Structure-Activity Relationship; Triazines; Triazoles | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Refinement of the benzodiazepine receptor site topology by structure-activity relationships of new N-(heteroarylmethyl)indol-3-ylglyoxylamides.
Topics: Amides; Animals; Binding Sites; Binding, Competitive; Cell Line; GABA-A Receptor Antagonists; Humans; Hydrogen Bonding; Indoles; Ligands; Molecular Structure; Rats; Stereoisomerism; Structure-Activity Relationship | 2006 |
Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-selective ligands.
Topics: Amides; Animals; Cattle; Cell Line; Cerebral Cortex; GABA-A Receptor Agonists; Glyoxylates; Hypnotics and Sedatives; In Vitro Techniques; Indoles; Ligands; Male; Mice; Mice, Inbred BALB C; Molecular Conformation; Motor Activity; Radioligand Assay; Rats; Structure-Activity Relationship | 2007 |
Novel 3-aroylpyrazolo[5,1-c][1,2,4]benzotriazine 5-oxides 8-substituted, ligands at GABAA/benzodiazepine receptor complex: synthesis, pharmacological and molecular modeling studies.
Topics: Animals; Anxiety; Behavior, Animal; Ethanol; Ligands; Male; Memory; Models, Molecular; Molecular Structure; Oxides; Pyrazoles; Rats; Receptors, GABA-A; Seizures; Sleep; Structure-Activity Relationship; Time Factors; Triazines | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit.
Topics: Animals; Behavior, Animal; Benzodiazepines; Chemical Phenomena; Chemistry, Physical; Computer Simulation; Databases, Factual; Electrophysiology; Female; Ligands; Male; Memory; Mice; Models, Molecular; Molecular Structure; Oocytes; Protein Isoforms; Protein Subunits; Quantitative Structure-Activity Relationship; Receptors, GABA-A; Structure-Activity Relationship; Xenopus laevis | 2008 |
Ethyl 8-fluoro-6-(3-nitrophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate as novel, highly potent, and safe antianxiety agent.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Binding Sites; Brain; Cattle; Computer Simulation; Crystallography, X-Ray; gamma-Aminobutyric Acid; Humans; Hydrogen Bonding; Imidazoles; Mice; Models, Molecular; Molecular Structure; Pentylenetetrazole; Seizures; Structure-Activity Relationship | 2008 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Synthesis, in vivo evaluation, and molecular modeling studies of new pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide derivatives. Identification of a bifunctional hydrogen bond area related to the inverse agonism.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Cattle; Drug Inverse Agonism; GABA-A Receptor Agonists; Hydrogen Bonding; Male; Mice; Models, Molecular; Motor Activity; Rats; Rats, Wistar; Receptors, GABA-A; Structure-Activity Relationship; Triazines | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
New fluoro derivatives of the pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide system: evaluation of fluorine binding properties in the benzodiazepine site on γ-aminobutyrric acid type A (GABA(A)) receptor. Design, synthesis, biological, and molecular modeling
Topics: Animals; Anti-Anxiety Agents; Binding Sites; Cattle; Cerebral Cortex; Crystallography, X-Ray; Drug Design; Drug Inverse Agonism; In Vitro Techniques; Male; Mice; Models, Molecular; Molecular Structure; Pyrazoles; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A; Structure-Activity Relationship; Triazines | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
New insight into the central benzodiazepine receptor-ligand interactions: design, synthesis, biological evaluation, and molecular modeling of 3-substituted 6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and related compounds.
Topics: Animals; Benzodiazepines; Binding Sites; Binding, Competitive; Cattle; Cerebral Cortex; Chlorides; Flumazenil; HEK293 Cells; Humans; Ligands; Male; Mice; Models, Molecular; Molecular Structure; Motor Activity; Protein Structure, Tertiary; Protein Subunits; Radioligand Assay; Receptors, GABA-A; Synaptosomes; Tritium; Xenopus laevis | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Design, Synthesis, and Biological Evaluation of Imidazo[1,5-a]quinoline as Highly Potent Ligands of Central Benzodiazepine Receptors.
Topics: Amnesia; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Binding Sites; Brain; Cattle; Drug Design; Humans; Ischemia; Ligands; Male; Mice; Models, Molecular; Neuroprotective Agents; Quinolines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Structure-Activity Relationship; Synaptosomes | 2016 |
Design, synthesis and biological evaluation of 7-substituted 4-phenyl-6H-imidazo[1,5-a]thieno[3,2-f] [1,4]diazepines as safe anxiolytic agents.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Binding Sites; Drug Design; Locomotion; Memory Disorders; Mice; Molecular Docking Simulation; Rats; Receptors, GABA-A | 2020 |
Evidence for more than two central benzodiazepine receptors in rat spinal cord.
Topics: Animals; Binding, Competitive; Diazepam; Flumazenil; Flunitrazepam; Rats; Receptors, GABA-A; RNA, Messenger; Spinal Cord | 1992 |
Relationship between benzodiazepine receptor occupancy and potentiation of gamma-aminobutyric acid-stimulated chloride flux in vitro of four ligands of differing intrinsic efficacies.
Topics: Animals; Benzodiazepinones; Cell Membrane; Cerebral Cortex; Chlorides; Diazepam; Drug Synergism; Flumazenil; gamma-Aminobutyric Acid; Ligands; Male; Rats; Receptors, GABA-A; Triazolam | 1992 |
Relationship between benzodiazepine receptor occupancy and functional effects in vivo of four ligands of differing intrinsic efficacies.
Topics: Administration, Oral; Animals; Benzodiazepinones; Diazepam; Dose-Response Relationship, Drug; Female; Flumazenil; Male; Mice; Mice, Inbred DBA; Motor Activity; Receptors, GABA-A; Seizures; Triazolam | 1992 |
Effects of flumazenil on intravenous lidocaine-induced convulsions and anticonvulsant property of diazepam in rats.
Topics: Animals; Anticonvulsants; Bicarbonates; Blood Pressure; Carbon Dioxide; Convulsants; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Heart Rate; Hydrogen-Ion Concentration; Infusions, Intravenous; Lidocaine; Male; Oxygen; Partial Pressure; Rats; Rats, Inbred Strains; Seizures | 1992 |
Effects of central and peripheral type benzodiazepine ligands on thyrotropin and prolactin secretion.
Topics: Animals; Benzodiazepinones; Carbolines; Clonazepam; Cold Temperature; Diazepam; Flumazenil; Hypothalamo-Hypophyseal System; Isoquinolines; Male; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Secretory Rate; Thyrotropin; Thyrotropin-Releasing Hormone | 1992 |
[Effects of agonists and antagonists of benzodiazepine, GABA and NMDA receptors, on caffeine-induced seizures in mice].
Topics: Animals; Baclofen; Benzodiazepines; Caffeine; Diazepam; Dizocilpine Maleate; Flumazenil; Male; Mice; Muscimol; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Receptors, Purinergic; Seizures | 1992 |
MDL 26,479: a potential cognition enhancer with benzodiazepine inverse agonist-like properties.
Topics: Animals; Behavior, Animal; Benzodiazepines; Binding Sites; Carbolines; Cognition; Convulsants; Diazepam; Flumazenil; Hemicholinium 3; Hippocampus; In Vitro Techniques; Male; Mice; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Triazoles | 1992 |
Tonic inhibition of striatal dopamine transmission: effects of benzodiazepine and GABAA receptor antagonists on extracellular dopamine levels.
Topics: Animals; Corpus Striatum; Dialysis; Diazepam; Dopamine; Dose-Response Relationship, Drug; Extracellular Space; Flumazenil; GABA-A Receptor Antagonists; Male; Pyridazines; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 1992 |
Effect of a new anxiolytic, DN-2327, on learning and memory in rats.
Topics: Animals; Anti-Anxiety Agents; Avoidance Learning; Buspirone; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Isoindoles; Learning; Male; Memory; Naphthyridines; Rats; Rats, Inbred Strains; Spiro Compounds | 1992 |
Like diazepam, CL 218,872, a selective ligand for the benzodiazepine omega 1 receptor subtype, impairs place learning in the Morris water maze.
Topics: Animals; Anti-Anxiety Agents; Diazepam; Flumazenil; Learning; Male; Memory; Motor Activity; Pyridazines; Rats; Receptors, GABA-A | 1992 |
Withdrawal precipitation by benzodiazepine receptor antagonists in dogs chronically treated with diazepam or the novel anxiolytic and anticonvulsant beta-carboline abecarnil.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Carbolines; Diazepam; Dogs; Female; Flumazenil; GABA-A Receptor Antagonists; Oxazepam; Substance Withdrawal Syndrome | 1992 |
Anticonflict action of tandospirone in a modified Geller-Seifter conflict test in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Behavior, Animal; Conditioning, Operant; Conflict, Psychological; Diazepam; Electroshock; Flumazenil; Isoindoles; Male; Piperazines; Pyrimidines; Rats; Rats, Inbred Strains; Tetrahydronaphthalenes | 1992 |
Substituted imidazo[1,2-b]pyridazines. New compounds with activity at central and peripheral benzodiazepine receptors.
Topics: Animals; Anti-Anxiety Agents; Binding, Competitive; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Imidazoles; Mice; Prosencephalon; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1992 |
Effects of benzodiazepine receptor ligands with different intrinsic activities on seizures induced by inhibition of GAD.
Topics: Animals; Anti-Anxiety Agents; Carbolines; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hippocampus; Isoniazid; Male; Mice; Mice, Inbred Strains; Pyrazoles; Reaction Time; Receptors, GABA-A; Seizures | 1992 |
[Extreme duration of action of diazepam as a cause of respiratory insufficiency in a female geriatric patient].
Topics: Aged; Diazepam; Female; Flumazenil; Humans; Postoperative Complications; Respiratory Insufficiency; Time Factors; Unconsciousness | 1992 |
Benzodiazepine-induced changes in biomembrane fluidity.
Topics: Chlordiazepoxide; Diazepam; Egg Yolk; Flumazenil; Lipid Bilayers; Liposomes; Membrane Fluidity; Models, Biological; Phosphatidylcholines; Spectrometry, Fluorescence | 1992 |
Pharmacological dissociation between the spatial learning deficits produced by morphine and diazepam.
Topics: Animals; Cues; Diazepam; Flumazenil; Learning; Male; Morphine; Naloxone; Rats; Space Perception | 1992 |
Quantitative electroencephalography for measurement of central nervous system responses to diazepam and the benzodiazepine antagonist, flumazenil, in isoflurane-anaesthetized dogs.
Topics: Anesthesia, Inhalation; Animals; Brain; Diazepam; Dogs; Electroencephalography; Female; Flumazenil; Hemodynamics; Isoflurane | 1992 |
Seizures after flumazenil administration in a case of combined benzodiazepine and tricyclic antidepressant overdose.
Topics: Adult; Clonazepam; Diazepam; Drug Overdose; Epilepsy, Tonic-Clonic; Female; Flumazenil; Humans; Imipramine; Poisoning | 1992 |
Tolerance, cross-tolerance and withdrawal in rats made dependent on diazepam.
Topics: Animals; Chlordiazepoxide; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Drug Tolerance; Flumazenil; Male; Midazolam; Pentylenetetrazole; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
The effects of centrally acting drugs on the EEG correlates of meditation.
Topics: Adult; Computers; Diazepam; Electroencephalography; Flumazenil; Humans; Male; Naloxone; Relaxation Therapy | 1992 |
Oral self-administration of triazolam, diazepam and ethanol in the baboon: drug reinforcement and benzodiazepine physical dependence.
Topics: Animals; Conditioning, Operant; Diazepam; Drinking Behavior; Ethanol; Flumazenil; Food; Half-Life; Male; Papio; Reinforcement Schedule; Reward; Self Administration; Substance Withdrawal Syndrome; Substance-Related Disorders; Triazolam | 1992 |
Effects of nitrendipine, chlordiazepoxide, flumazenil and baclofen on the increased anxiety resulting from alcohol withdrawal.
Topics: Animals; Anxiety; Baclofen; Chlordiazepoxide; Diazepam; Ethanol; Flumazenil; Interpersonal Relations; Male; Nitrendipine; Rats; Substance Withdrawal Syndrome; Tremor | 1992 |
Locomotor responses to benzodiazepines, barbiturates and ethanol in diazepam-sensitive (DS) and -resistant (DR) mice.
Topics: Analysis of Variance; Animals; Diazepam; Dose-Response Relationship, Drug; Ethanol; Female; Flumazenil; Flunitrazepam; Male; Mice; Motor Activity; Pentobarbital; Phenobarbital | 1992 |
Repeated anticonvulsant testing: contingent tolerance to diazepam and clobazam in kindled rats.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Diazepam; Drug Tolerance; Flumazenil; Kindling, Neurologic; Male; Radioligand Assay; Rats; Rats, Inbred Strains; Seizures | 1992 |
Flumazenil does not antagonize halothane, thiamylal or propofol anaesthesia in rats.
Topics: Anesthesia, Inhalation; Anesthesia, Intravenous; Animals; Behavior, Animal; Diazepam; Drug Interactions; Electroencephalography; Flumazenil; Halothane; Male; Propofol; Rats; Rats, Inbred Strains; Sleep; Thiamylal | 1992 |
Elevated brain concentrations of 1,4-benzodiazepines in fulminant hepatic failure.
Topics: Adult; Aged; Benzodiazepines; Brain Chemistry; Chromatography; Diazepam; Flumazenil; Frontal Lobe; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Humans; Mass Spectrometry; Middle Aged; Nordazepam; Receptors, GABA-A; Synaptic Transmission | 1991 |
Action of diazepam on the voltage-dependent Na+ current. Comparison with the effects of phenytoin, carbamazepine, lidocaine and flumazenil.
Topics: Action Potentials; Animals; Carbamazepine; Cell Line; Cells, Cultured; Diazepam; Embryo, Mammalian; Flumazenil; Kinetics; Lidocaine; Mice; Neuroblastoma; Neurons; Phenytoin; Sodium Channels; Spinal Cord | 1991 |
Benzodiazepine receptor ligands and sexual behavior in the male rat: the role of GABAergic mechanisms.
Topics: Animals; Bicuculline; Carbolines; Chlordiazepoxide; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Male; Motor Activity; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sexual Behavior, Animal | 1991 |
SPECT imaging of the benzodiazepine receptor: feasibility of in vivo potency measurements from stepwise displacement curves.
Topics: Alprazolam; Animals; Benzodiazepines; Brain; Brain Chemistry; Clonazepam; Diazepam; Female; Flumazenil; Injections, Intravenous; Macaca mulatta; Male; Papio; Receptors, GABA-A; Tomography, Emission-Computed, Single-Photon | 1991 |
In vivo bidirectional modulatory effect of benzodiazepine receptor ligands on GABAergic transmission evaluated by positron emission tomography in non-human primates.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Carbolines; Cerebral Cortex; Diazepam; Electroencephalography; Flumazenil; gamma-Aminobutyric Acid; Ligands; Male; Papio; Pentylenetetrazole; Receptors, GABA-A; Seizures; Synaptic Transmission; Tomography, Emission-Computed | 1991 |
Behavioral effects of benzodiazepine ligands in non-dependent, diazepam-dependent and diazepam-withdrawn baboons.
Topics: Animals; Behavior, Animal; Benzodiazepines; Carbolines; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Flumazenil; Ligands; Male; Midazolam; Papio; Receptors, GABA-A; Social Behavior; Substance Withdrawal Syndrome; Substance-Related Disorders | 1991 |
Modulation of noise-potentiated acoustic startle via the benzodiazepine--gamma-aminobutyric acid receptor complex.
Topics: Acoustic Stimulation; Animals; Auditory Perception; Benzodiazepinones; Brain; Convulsants; Diazepam; Flumazenil; GABA-A Receptor Antagonists; Male; Neurons; Rats; Receptors, GABA-A; Reflex, Startle | 1991 |
Flumazenil as an anti-epileptic agent.
Topics: Diazepam; Drug Evaluation; Epilepsy; Flumazenil; Humans; Time Factors | 1991 |
Pharmacologic profile of a new anxiolytic, DN-2327: effect of Ro15-1788 and interaction with diazepam in rodents.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Conditioning, Operant; Conflict, Psychological; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Flumazenil; Isoindoles; Male; Mice; Mice, Inbred ICR; Muscle Relaxation; Naphthyridines; Pentobarbital; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Spiro Compounds | 1991 |
Involvement of the GABAA/benzodiazepine chloride ionophore receptor complex in the 5,7-DHT Induced anticonflict effect.
Topics: 5,7-Dihydroxytryptamine; Animals; Anti-Anxiety Agents; Azides; Benzodiazepines; Bicuculline; Diazepam; Drinking Behavior; Electroshock; Flumazenil; Hippocampus; Injections, Intraventricular; Limbic System; Male; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Serotonin | 1991 |
Evidence for a role for dopamine in the diazepam locomotor stimulating effect.
Topics: alpha-Methyltyrosine; Animals; Benzazepines; Diazepam; Dopamine; Flumazenil; Haloperidol; Male; Methyltyrosines; Mice; Motor Activity; Spiperone; Stimulation, Chemical; Tyrosine 3-Monooxygenase | 1991 |
[Behavioral pharmacological and electroencephalographic effects of the 5-HT1A partial agonist ipsapirone].
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Buspirone; Diazepam; Drug Synergism; Electroencephalography; Flumazenil; Male; Mice; Motor Activity; Pyrimidines; Rabbits; Rats; Rats, Inbred Strains; Serotonin | 1991 |
The discriminative stimulus effects of diazepam in rats at two training doses.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Buspirone; Carbolines; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Flumazenil; Male; Morphine; Pentobarbital; Pyrazoles; Pyridazines; Rats; Rats, Inbred Strains; Triazolam | 1991 |
Central-type benzodiazepines inhibit release of alpha-melanocyte-stimulating hormone from the rat hypothalamus.
Topics: Animals; Anti-Anxiety Agents; beta-Endorphin; Clonazepam; Diazepam; Flumazenil; GABA Antagonists; Hypothalamus; In Vitro Techniques; Male; Melanocyte-Stimulating Hormones; Perfusion; Pituitary Gland; Potassium Chloride; Pro-Opiomelanocortin; Pyridazines; Radioimmunoassay; Rats; Rats, Inbred Strains | 1991 |
Behavioral effects of U-78875, a quinoxalinone anxiolytic with potent benzodiazepine antagonist activity.
Topics: Animals; Anti-Anxiety Agents; Avoidance Learning; Behavior, Animal; Diazepam; Electroencephalography; Flumazenil; Injections, Intraperitoneal; Male; Motor Activity; Oxadiazoles; Quinoxalines; Rats; Rats, Inbred F344 | 1991 |
Chronic administration of and dependence on halazepam, diazepam, and nordiazepam in the dog.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Brain; Diazepam; Dogs; Dose-Response Relationship, Drug; Flumazenil; Neurologic Examination; Nordazepam; Substance Withdrawal Syndrome; Substance-Related Disorders | 1991 |
Effects of DN-2327, a new anxiolytic, diazepam and buspirone on exploratory activity of the rat in an elevated plus-maze.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Buspirone; Conflict, Psychological; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Exploratory Behavior; Flumazenil; Isoindoles; Male; Naphthyridines; Pentylenetetrazole; Rats; Rats, Inbred Strains; Spiro Compounds; Yohimbine | 1991 |
The negative inotropic effect of diazepam in rat right ventricular strips.
Topics: Animals; Depression, Chemical; Diazepam; Electric Stimulation; Female; Flumazenil; Heart Ventricles; In Vitro Techniques; Isoquinolines; Male; Myocardial Contraction; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1991 |
Psychological stress increases dopamine turnover selectively in mesoprefrontal dopamine neurons of rats: reversal by diazepam.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Catecholamines; Corticosterone; Diazepam; Dopamine; Electroshock; Flumazenil; Frontal Lobe; Homovanillic Acid; Indoles; Male; Nerve Endings; Neurons; Rats; Rats, Inbred Strains; Stress, Psychological; Tegmentum Mesencephali | 1991 |
Flumazenil for the reversal of refractory benzodiazepine-induced shock.
Topics: Aged; Cardiovascular System; Central Nervous System; Diazepam; Female; Flumazenil; Humans; Respiration; Shock | 1991 |
[The use of flumazenil to antagonize the effect of diazepam after bronchoscopy].
Topics: Adult; Bronchoscopy; Diazepam; Female; Flumazenil; Humans; Male; Middle Aged | 1991 |
Effects of a benzodiazepine antagonist, Ro 15-1788, on hippocampal field potentials in freely moving rats.
Topics: Animals; Depression, Chemical; Diazepam; Evoked Potentials; Flumazenil; Hippocampus; Male; Rats; Rats, Inbred Strains | 1991 |
Correlation between gamma-aminobutyric acidA receptor ligand-induced changes in t-butylbicyclophosphoro[35S]thionate binding and 36Cl- uptake in rat cerebrocortical membranes.
Topics: Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Cerebral Cortex; Chloride Channels; Chlorides; Desoxycorticosterone; Diazepam; Ethanol; Flumazenil; gamma-Aminobutyric Acid; In Vitro Techniques; Ligands; Membrane Proteins; Pentobarbital; Pregnanolone; Rats; Receptors, GABA-A; Synaptosomes | 1991 |
The contribution of endogenous benzodiazepine receptor ligands to the pathogenesis of hepatic encephalopathy.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chromatography, High Pressure Liquid; Diazepam; Flumazenil; Hepatic Encephalopathy; Kinetics; Ligands; Male; Mass Spectrometry; Muscimol; Peripheral Nerves; Rabbits; Radioligand Assay; Receptors, GABA-A; Sulfur Radioisotopes | 1991 |
[Accidental diazepam overdose in a 12-month-old infant. Therapy using flumazenil].
Topics: Accidents; Diazepam; Flumazenil; Humans; Infant | 1991 |
Effects of diazepam and Ro 15-1788 on duodenal bicarbonate secretion in the rat.
Topics: Animals; Bicarbonates; Diazepam; Duodenum; Flumazenil; Intestinal Mucosa; Intestinal Secretions; Male; Rana catesbeiana; Rats; Rats, Inbred Strains; Stimulation, Chemical; Trimipramine; Vagus Nerve | 1991 |
Antagonism by propyl-beta-carboline-3-carboxylate of passive avoidance impairment induced by diazepam.
Topics: Animals; Avoidance Learning; Carbolines; Convulsants; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Learning; Male; Memory; Mice; Mice, Inbred Strains | 1991 |
Effects of forced shaking stress at low temperature on pentobarbital-induced sleeping in mice.
Topics: Animals; Cold Temperature; Diazepam; Drug Resistance; Flumazenil; Male; Mice; Naloxone; Nociceptors; Pentobarbital; Sleep; Stress, Physiological | 1991 |
A comparison of the physical dependence inducing properties of flunitrazepam and diazepam.
Topics: Animals; Biotransformation; Blood Proteins; Brain Chemistry; Diazepam; Dogs; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; Protein Binding; Seizures; Substance Withdrawal Syndrome; Substance-Related Disorders | 1991 |
Relative efficacies of benzodiazepine receptor agonists in affecting red nucleus electrical activity in rabbits.
Topics: Animals; Bicuculline; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; Imidazoles; Isoquinolines; Male; Pentylenetetrazole; Pyridazines; Pyridines; Rabbits; Receptors, GABA-A; Red Nucleus; Zolpidem | 1990 |
Behavioral neurobiology of inverse agonist FG 7142 induced anxiety syndrome in rats.
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Avoidance Learning; Carbolines; Diazepam; Exploratory Behavior; Flumazenil; Grooming; Male; Motor Activity; Rats; Rats, Inbred Strains; Stereotyped Behavior | 1990 |
Reduction of reticulata neuronal activity by zolpidem and alpidem, two imidazopyridines with high affinity for type I benzodiazepine receptors.
Topics: Action Potentials; Animals; Anti-Anxiety Agents; Diazepam; Flumazenil; Hypnotics and Sedatives; Imidazoles; Male; Neurons; Pyridines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Reticular Formation; Zolpidem | 1990 |
Differential interactions of Ro 15-4513 with benzodiazepines, ethanol and pentobarbital.
Topics: Anesthesia; Animals; Anti-Anxiety Agents; Azides; Behavior, Animal; Benzodiazepines; Diazepam; Drug Interactions; Ethanol; Female; Flumazenil; Male; Muscle Contraction; Muscles; Pentobarbital; Rats; Rats, Inbred Strains; Urethane; Vocalization, Animal | 1990 |
Benzodiazepine receptor ligand influences on acquisition: suggestion of an endogenous modulatory mechanism mediated by benzodiazepine receptors.
Topics: Animals; Anti-Anxiety Agents; Arousal; Avoidance Learning; Benzodiazepinones; Brain; Carbolines; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Exploratory Behavior; Female; Flumazenil; Habituation, Psychophysiologic; Memory; Mental Recall; Rats; Rats, Inbred Strains; Reaction Time; Receptors, GABA-A; Retention, Psychology | 1990 |
A theory of benzodiazepine dependence that can explain whether flumazenil will enhance or reverse the phenomena.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Flumazenil; Male; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 1990 |
Benzodiazepines and synaptic processing in the spatial domain within the cat's primary somatosensory cortex.
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Cats; Diazepam; Electric Stimulation; Electrophysiology; Female; Flumazenil; Fluphenazine; gamma-Aminobutyric Acid; Male; Midazolam; Physical Stimulation; Somatosensory Cortex; Space Perception; Synapses | 1990 |
Effect of serotoninergic drugs on stress-induced hyperthermia (SIH) in mice.
Topics: 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Body Temperature Regulation; Buspirone; Diazepam; Ergolines; Fenclonine; Fever; Flumazenil; Imidazoles; Male; Mice; Ondansetron; Piperazines; Piperidines; Ritanserin; Serotonin; Serotonin Antagonists; Stress, Psychological; Tetrahydronaphthalenes | 1990 |
Increased sensitivity to benzodiazepine antagonists in rats following chronic treatment with a low dose of diazepam.
Topics: Animals; Anti-Anxiety Agents; Conditioning, Operant; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Food; Male; Pyrazoles; Rats; Rats, Inbred Strains; Reinforcement Schedule; Reinforcement, Psychology | 1990 |
Relaxant effect of benzodiazepines on uterine rings isolated from estrogen-treated rats.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Bicuculline; Clonazepam; Convulsants; Diazepam; Estradiol; Estrogens; Female; Flumazenil; In Vitro Techniques; Isoquinolines; Muscle, Smooth; Potassium Chloride; Propranolol; Rats; Rats, Inbred Strains; Uterine Contraction | 1990 |
Which agent and how to deliver it? A review of benzodiazepine sedation and its reversal in endoscopy.
Topics: Analgesics, Opioid; Anti-Anxiety Agents; Conscious Sedation; Diazepam; Endoscopy, Gastrointestinal; Flumazenil; Humans; Midazolam | 1990 |
Preferential decrease in dopamine utilization in prefrontal cortex by zopiclone, diazepam and zolpidem in unstressed rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Azabicyclo Compounds; Cerebral Cortex; Corpus Striatum; Diazepam; Dopamine; Flumazenil; Male; Piperazines; Pyridines; Rats; Rats, Inbred Strains; Stress, Physiological; Zolpidem | 1990 |
Benzodiazepine-induced antagonism of opioid antinociception may be abolished by spinalization or blockade of the benzodiazepine receptor.
Topics: Analgesics; Animals; Anti-Anxiety Agents; Diazepam; Flumazenil; Male; Mice; Midazolam; Morphine; Narcotics; Nordazepam; Psychomotor Performance; Reaction Time; Receptors, GABA-A; Receptors, Opioid; Skin Temperature; Spinal Cord | 1990 |
Cardiorespiratory effects of antagonism of diazepam sedation with flumazenil in patients with cardiac disease.
Topics: Aged; Cardiac Catheterization; Coronary Angiography; Coronary Disease; Diazepam; Female; Flumazenil; Heart; Heart Diseases; Heart Valve Diseases; Hemodynamics; Humans; Hypnotics and Sedatives; Male; Middle Aged; Respiratory System | 1991 |
Flumazenil therapy in benzodiazepine self-poisoning.
Topics: Adult; Diazepam; Female; Flumazenil; Humans; Lorazepam; Middle Aged; Poisoning | 1991 |
Flumazenil and hypoxic ventilatory response.
Topics: Diazepam; Flumazenil; Humans; Hypoxia; Respiration | 1990 |
Diazepam-binding inhibitor: a neuropeptide and/or an acyl-CoA ester binding protein?
Topics: Acyl Coenzyme A; Adrenal Cortex; Amino Acid Sequence; Animals; Benzodiazepinones; Brain; Carboxylic Acids; Carrier Proteins; Cattle; Diazepam; Diazepam Binding Inhibitor; Esters; Flumazenil; Liver; Molecular Sequence Data; Nerve Tissue Proteins; Neuropeptides; Peptide Fragments; Rats | 1990 |
3-((+-)-2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) and phencyclidine produce a deficit of passive avoidance retention in rats.
Topics: Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Latency Period, Psychological; Male; Phencyclidine; Piperazines; Rats; Rats, Inbred Strains | 1990 |
Pharmacological manipulation of anxiety and male rat sexual behavior.
Topics: Animals; Anxiety; Carbolines; Copulation; Diazepam; Flumazenil; Male; Psychomotor Performance; Rats; Rats, Inbred Strains | 1990 |
Methyl beta-carboline-3-carboxylate enhances performance in a multiple-trial learning task in mice.
Topics: Animals; Benzodiazepines; Carbolines; Diazepam; Drug Synergism; Flumazenil; Learning; Male; Mice; Retention, Psychology | 1990 |
Diazepam and Ro 15-1788 increase absence epilepsy in WAG/Rij rats chronically exposed to diazepam.
Topics: Animals; Diazepam; Electroencephalography; Epilepsy; Flumazenil; Hypnotics and Sedatives; Male; Rats; Rats, Inbred Strains | 1990 |
Enhancing effects of Ro 15-1788 on straw-climbing behavior as measured with the straw-suspension method: reversal by diazepam.
Topics: Animals; Anxiety; Diazepam; Drug Interactions; Flumazenil; Male; Motor Activity; Rats; Rats, Inbred Strains | 1990 |
Blockade of hoarding in rats by diazepam: an analysis of the anxiety and object value hypotheses of hoarding.
Topics: Animals; Anxiety; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Eating; Female; Flumazenil; Food Deprivation; Learning; Male; Rats | 1990 |
[Buspirone: correlation of its anxiolytic and electroencephalographic effects].
Topics: Animals; Buspirone; Diazepam; Dose-Response Relationship, Drug; Electroencephalography; Flumazenil; Fourier Analysis; Male; Rats; Somatosensory Cortex; Time Factors | 1990 |
[The effect of RO15-1788 on the interaction between pancuronium and diazepam].
Topics: Animals; Diazepam; Drug Interactions; Flumazenil; Male; Neuromuscular Junction; Pancuronium; Rats; Rats, Inbred Strains | 1990 |
Anticonvulsive properties of F1933 (dulozafone) on kindled seizures in the rat.
Topics: Acetanilides; Amygdala; Animals; Anticonvulsants; Diazepam; Electric Stimulation; Flumazenil; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains; Seizures | 1990 |
Early developmental exposure to benzodiazepine ligands alters brain 31P-NMR spectra in young adult rats.
Topics: Animals; Brain; Diazepam; Female; Flumazenil; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Phosphocreatine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Receptors, GABA-A | 1990 |
beta-CCM inhibits muricide induced by olfactory bulbectomy in rats.
Topics: Aggression; Animals; Brain; Carbolines; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Injections, Intravenous; Male; Mice; Motor Activity; Muscle Relaxants, Central; Olfactory Bulb; Phenoxybenzamine; Postural Balance; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1990 |
Behavioral analysis of the effects of benzodiazepine receptor ligands in the conditioned burying paradigm.
Topics: Animals; Arousal; Benzodiazepinones; Brain; Carbolines; Conditioning, Classical; Diazepam; Dose-Response Relationship, Drug; Electroshock; Fear; Flumazenil; Grooming; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stereotyped Behavior | 1990 |
Benzodiazepine receptors modulate 5-hydroxytryptamine neurotransmission in the rat hippocampus: in vivo electrophysiological evidence.
Topics: Animals; Carbolines; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Hippocampus; Male; Piperazines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Serotonin; Synaptic Transmission | 1990 |
Proconflict effect of ACTH1-24: interaction with benzodiazepines.
Topics: Adrenocorticotropic Hormone; alpha-MSH; Animals; Anxiety; Conflict, Psychological; Cosyntropin; Diazepam; Electroshock; Flumazenil; Injections, Intraventricular; Male; Peptide Fragments; Rats; Rats, Inbred Strains; Stress, Physiological | 1990 |
Enkephalin biosynthesis and release in mouse striatum are inhibited by GABA receptor stimulation: compared changes in preproenkephalin mRNA and Tyr-Gly-Gly levels.
Topics: Aminooxyacetic Acid; Animals; Corpus Striatum; Diazepam; Enkephalins; Flumazenil; Kinetics; Leucine; Male; Mice; Muscimol; Oligopeptides; Protein Precursors; Receptors, GABA-A; RNA, Messenger | 1990 |
The benzodiazepine receptor inverse agonist DMCM decreases serotonergic transmission in rat hippocampus: an in vivo electrophysiological study.
Topics: Animals; Carbolines; Diazepam; Electrophysiology; Flumazenil; Hippocampus; Neural Pathways; Pargyline; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, GABA-A; Serotonin; Synaptic Transmission | 1990 |
Profound stress-induced alterations in flurazepam's antiseizure efficacy can be attenuated.
Topics: Animals; Carbolines; Clonazepam; Cold Temperature; Diazepam; Dose-Response Relationship, Drug; Electroshock; Flumazenil; Flurazepam; Male; Mice; Mice, Inbred Strains; Midazolam; Seizures; Stress, Psychological | 1990 |
Adenosine receptor antagonism accounts for the seizure-prolonging effects of aminophylline.
Topics: Adenosine; Aminophylline; Amygdala; Animals; Brain; Carbolines; Diazepam; Flumazenil; Kindling, Neurologic; Male; Picrotoxin; Pyrazoles; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Purinergic; Rolipram; Seizures; Theophylline; Xanthines | 1990 |
Differential actions of RO 15-1788 and diazepam on poikilothermia, motor impairment and sleep produced by ethanol.
Topics: Animals; Body Temperature; Body Temperature Regulation; Diazepam; Drug Interactions; Ethanol; Flumazenil; Injections, Intraperitoneal; Male; Psychomotor Performance; Rats; Rats, Inbred Strains; Sleep | 1990 |
[The risks of diazepam in newborn infants].
Topics: Diazepam; Flumazenil; Humans; Infant, Newborn; Respiratory Insufficiency | 1990 |
Benzodiazepine withdrawal syndrome after a benzodiazepine antagonist.
Topics: Adolescent; Akathisia, Drug-Induced; Diazepam; Drug Overdose; Flumazenil; Humans; Injections, Intravenous; Intubation, Gastrointestinal; Lorazepam; Male; Psychomotor Agitation; Substance Withdrawal Syndrome; Therapeutic Irrigation; Thiopental | 1990 |
[Antagonism of diazepam-induced sedative effects by flumazenil in patients after surgery under lumbar spinal or epidural anesthesia].
Topics: Adult; Aged; Anesthesia Recovery Period; Anesthesia, Epidural; Anesthesia, Spinal; Diazepam; Female; Flumazenil; Humans; Male; Middle Aged | 1990 |
[EEG analysis of the effectiveness of the benzodiazepine antagonist RO 15-1788 after diazepam sedation].
Topics: Adult; Diazepam; Electroencephalography; Evaluation Studies as Topic; Flumazenil; Humans; Male | 1990 |
[Clinical investigation of flumazenil in reversing the respiratory effects of diazepam].
Topics: Aged; Diazepam; Female; Flumazenil; Humans; Male; Middle Aged; Respiration | 1990 |
Pharmacological inhibition of forskolin-stimulated adenylate cyclase activity in rat brain by melatonin, its analogs, and diazepam.
Topics: Adenylyl Cyclases; Animals; Benzodiazepinones; Brain; Brain Mapping; Cell Membrane; Colforsin; Corpus Striatum; Diazepam; Dose-Response Relationship, Drug; Enzyme Activation; Flumazenil; In Vitro Techniques; Male; Melatonin; Rats; Rats, Inbred Strains | 1990 |
[Flumazenil: possible suppression of the antipsychotic effect of diazepam in anesthesia with ketamine].
Topics: Adult; Diazepam; Female; Flumazenil; Humans; Ketamine; Male; Middle Aged; Random Allocation | 1990 |
Rat pup ultrasonic isolation calls: possible mediation by the benzodiazepine receptor complex.
Topics: Animals; Benzodiazepinones; Chlorides; Diazepam; Flumazenil; Ion Channels; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sex Factors; Temperature; Vocalization, Animal | 1986 |
The effect of diazepam and Ro 15-1788 on extracellular ascorbic acid, DOPAC and 5-HIAA in the striatum of anaesthetized and conscious freely moving rats, as measured by differential pulse voltammetry.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Ascorbic Acid; Corpus Striatum; Diazepam; Electrochemistry; Extracellular Space; Flumazenil; Hydroxyindoleacetic Acid; Male; Rats; Rats, Inbred Strains | 1987 |
Partial agonists of the benzodiazepine receptor: from animal data to results in patients.
Topics: Affinity Labels; Allosteric Site; Animals; Azides; Benzodiazepines; Benzodiazepinones; Chlordiazepoxide; Chlorides; Clonazepam; Diazepam; Drug Interactions; Ethanol; Flumazenil; Flurazepam; Humans; Ion Channels; Ligands; Models, Neurological; Neurons; Receptors, GABA-A | 1988 |
The effect of diazepam on ventricular automaticity induced by a local injury. Evidence of involvement of "peripheral type" benzodiazepine receptors.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Diazepam; Diltiazem; Dose-Response Relationship, Drug; Female; Flumazenil; Heart Ventricles; Isoquinolines; Male; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Ventricular Function | 1989 |
Diminution by benzodiazepines of the chronotropic responses to noradrenaline in rat isolated atria.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Anti-Anxiety Agents; Benzodiazepinones; Clonazepam; Colforsin; Cyclic AMP; Diazepam; Female; Flumazenil; Heart; Heart Rate; In Vitro Techniques; Isoquinolines; Male; Myocardium; Norepinephrine; Rats; Rats, Inbred Strains | 1989 |
Both systemic and local administration of benzodiazepine agonists inhibit the in vivo release of 5-HT from ventral hippocampus.
Topics: Animals; Benzodiazepines; Carbolines; Chromatography, High Pressure Liquid; Dialysis; Diazepam; Flumazenil; Flurazepam; Hippocampus; Hydroxyindoleacetic Acid; Ion Channels; Male; Muscimol; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Serotonin | 1989 |
Effects of diazepam and flumazenil on sedation and hypoxic ventilatory response.
Topics: Adult; Brain; Diazepam; Flumazenil; Humans; Hypnotics and Sedatives; Hypoxia; Respiration | 1989 |
Sedation and reversal of sedation in intensive care.
Topics: Adolescent; Adult; Aged; Anesthesia Recovery Period; Blood Pressure; Carbon Dioxide; Diazepam; Female; Flumazenil; Heart Rate; Humans; Male; Midazolam; Middle Aged; Postoperative Period; Preanesthetic Medication; Respiration | 1989 |
Appetite-modulating drugs in dwarf goats, with special emphasis on benzodiazepine-induced hyperphagia and its antagonism by flumazenil and RO 15-3505.
Topics: Animals; Anti-Anxiety Agents; Appetite Regulation; Azepines; Benzodiazepines; Benzodiazepinones; Body Weight; Diazepam; Female; Flumazenil; Goats; Hyperphagia; Ivermectin; Male; Midazolam; Time Factors | 1989 |
Ethanol and diazepam withdrawal convulsions are extensively codetermined in WSP and WSR mice.
Topics: Animals; Diazepam; Ethanol; Flumazenil; Mice; Mice, Inbred Strains; Seizures; Substance Withdrawal Syndrome; Substance-Related Disorders | 1989 |
Inhibition of high-affinity synaptosomal uptake of gamma-aminobutyric acid by a bicyclo-heptane derivative.
Topics: Animals; Anticonvulsants; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Camphanes; Carbolines; Cerebral Cortex; Diazepam; Flumazenil; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Synaptic Membranes; Synaptosomes | 1989 |
Opposite effects of diazepam and beta-CCE on immobility and straw-climbing behavior of rats in a modified forced-swim test.
Topics: Animals; Carbolines; Diazepam; Flumazenil; Male; Motor Activity; Rats; Rats, Inbred Strains; Stress, Psychological; Swimming | 1989 |
Benzodiazepines acting on ventral surface of medulla cause airway dilation.
Topics: Animals; Atropine; Blood Pressure; Cats; Diazepam; Female; Flumazenil; Lung; Male; Medulla Oblongata; Midazolam; Muscle Relaxation; Muscle, Smooth; Phrenic Nerve; Trachea | 1989 |
Blockade by diazepam of conditioned fear-induced activation of rat mesoprefrontal dopamine neurons.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemistry; Conditioning, Psychological; Corticosterone; Diazepam; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Fear; Flumazenil; Male; Rats; Rats, Inbred Strains; Stress, Psychological | 1989 |
Relationship of agonist efficacy to changes in GABA sensitivity and anticonvulsant tolerance following chronic benzodiazepine ligand exposure.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Bicuculline; Brain Chemistry; Diazepam; Drug Tolerance; Electrophysiology; Flumazenil; gamma-Aminobutyric Acid; Male; Raphe Nuclei; Rats; Rats, Inbred Strains; Seizures | 1989 |
Responses of substantia nigra pars reticulata neurons to benzodiazepine ligands after acute and prolonged diazepam exposure. I. Modulation of gamma-aminobutyric acid sensitivity.
Topics: Animals; Carbolines; Diazepam; Flumazenil; Flurazepam; gamma-Aminobutyric Acid; Ligands; Male; Neurons; Rats; Rats, Inbred Strains; Receptors, GABA-A; Substantia Nigra | 1989 |
Responses of substantia nigra pars reticulata neurons to benzodiazepine ligands after acute and prolonged diazepam exposure. II. Modulation of firing rate.
Topics: Animals; Carbolines; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Ligands; Male; Neurons; Rats; Rats, Inbred Strains; Receptors, GABA-A; Substantia Nigra | 1989 |
Role of the central benzodiazepine receptor system in behavioral habituation to novelty.
Topics: Animals; Carbolines; Diazepam; Exploratory Behavior; Flumazenil; Habituation, Psychophysiologic; Male; Rats; Reaction Time; Receptors, GABA-A | 1989 |
Effects of peripheral benzodiazepines upon the O2 consumption of neuroblastoma cells.
Topics: Animals; Benzodiazepines; Cells, Cultured; Clonazepam; Clone Cells; Diazepam; Flumazenil; Isoquinolines; Mice; Mitochondria; Neuroblastoma; Oxygen Consumption; Receptors, GABA-A | 1989 |
Population differences in benzodiazepine sensitive male scent-induced analgesia in the deer mouse, Peromyscus maniculatus.
Topics: Analgesia; Animals; Central Nervous System; Diazepam; Flumazenil; Male; Mice; Naloxone; Olfactory Pathways; Peromyscus; Receptors, GABA-A; Receptors, Opioid | 1989 |
GABA[A] receptor level changes in female hamster forebrain following in vivo estrogen progesterone and benzodiazepine treatment: a quantitative autoradiography analysis.
Topics: Animals; Autoradiography; Benzodiazepines; Cricetinae; Diazepam; Estradiol; Female; Flumazenil; Frontal Lobe; Muscimol; Ovariectomy; Progesterone; Receptors, GABA-A | 1989 |
Co-administration of Ro 15-1788 prevents diazepam-induced retardation of recovery of function.
Topics: Animals; Diazepam; Flumazenil; Functional Laterality; Male; Rats; Receptors, GABA-A; Somatosensory Cortex; Time Factors | 1989 |
The relationship of benzodiazepine binding sites to the norepinephrine projection in the hypothalamus of the adult rat.
Topics: Animals; Diazepam; Flumazenil; Flunitrazepam; Hypothalamus; Norepinephrine; Rats; Receptors, GABA-A | 1989 |
Type I and type II GABAA-benzodiazepine receptors produced in transfected cells.
Topics: Cell Line; Diazepam; Flumazenil; Flunitrazepam; Humans; Molecular Weight; Pyridazines; Receptors, GABA-A; Recombinant Proteins; Transfection | 1989 |
Modification of evoked hippocampal dentate inhibition by diazepam and three antagonists in urethane-anesthetized rats.
Topics: Anesthesia; Animals; Diazepam; Evoked Potentials; Flumazenil; gamma-Aminobutyric Acid; Hippocampus; Isoquinolines; Male; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synapses; Urethane | 1989 |
Benzodiazepine receptor autoradiography in corpus striatum of rat after large frontal cortex lesions and chronic treatment with diazepam.
Topics: Animals; Autoradiography; Behavior, Animal; Cerebral Cortex; Corpus Striatum; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Male; Nucleus Accumbens; Rats; Receptors, GABA-A; Time Factors | 1989 |
Early developmental exposure to benzodiazepine ligands alters brain levels of thiobarbituric acid-reactive products in young adult rats.
Topics: Animals; Benzodiazepines; Brain; Clonazepam; Diazepam; Female; Flumazenil; Gestational Age; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Receptors, GABA-A; Thiobarbiturates | 1989 |
Blockade of the development of analgesic tolerance to morphine by psychological stress through benzodiazepine receptor mediated mechanism.
Topics: Analgesia; Animals; Carbolines; Diazepam; Drug Tolerance; Flumazenil; Male; Mice; Morphine; Receptors, GABA-A; Stress, Psychological | 1989 |
Efficacy of flumazenil in COPD patient with therapeutic diazepam levels.
Topics: Aged; Diazepam; Drug Evaluation; Flumazenil; Humans; Lung Diseases, Obstructive; Male; Nordazepam | 1989 |
Aminophylline reversal of diazepam intoxication.
Topics: Aminophylline; Diazepam; Flumazenil; Half-Life; Humans; Male; Respiratory Insufficiency | 1989 |
Physical dependence on diazepam in the dog: precipitation of different abstinence syndromes by the benzodiazepine receptor antagonists Ro 15-1788 and ZK 93426.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Carbolines; Diazepam; Dogs; Female; Flumazenil; Nordazepam; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1989 |
Anticonvulsant and other effects of diazepam grow with time after a single treatment.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Anticonvulsants; Antipsychotic Agents; Blepharoptosis; Brain Chemistry; Catalepsy; Diazepam; Dopamine; Drug Interactions; Flumazenil; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Stress, Psychological; Time Factors | 1989 |
Cerebral-activating (EEG) properties of two inverse agonists and of an antagonist at the benzodiazepine receptor in the rat.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Central Nervous System Stimulants; Chlorpromazine; Diazepam; Electroencephalography; Flumazenil; Imipramine; Male; Pentobarbital; Pyrazoles; Pyridazines; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1989 |
The effects of ondansetron (GR38032F) in rats and mice treated subchronically with diazepam.
Topics: Animals; Anti-Anxiety Agents; Avoidance Learning; Buspirone; Darkness; Diazepam; Flumazenil; Imidazoles; Light; Male; Mice; Mice, Inbred Strains; Ondansetron; Rats; Rats, Inbred Strains; Serotonin Antagonists; Social Behavior; Substance Withdrawal Syndrome; Time Factors | 1989 |
Mouse lines selected for genetic differences in diazepam sensitivity.
Topics: Animals; Brain; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Mice; Mice, Inbred Strains; Motor Skills; Receptors, GABA-A; Selection, Genetic | 1987 |
Inhibition of rat brain adenylate cyclase activity by benzodiazepine through the effects on Gi and catalytic proteins.
Topics: Adenylyl Cyclase Inhibitors; Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Benzodiazepines; Brain; Chlorides; Diazepam; Flumazenil; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptic Membranes | 1988 |
Are the analgesic effects of social defeat mediated by benzodiazepine receptors?
Topics: Analgesia; Animals; Behavior, Animal; Carbolines; Diazepam; Flumazenil; Male; Mice; Mice, Inbred DBA; Pyrazoles; Receptors, GABA-A; Social Behavior | 1987 |
Heterogeneity of gamma-aminobutyric acid/benzodiazepine/beta-carboline receptor complex in rat spinal cord.
Topics: Animals; Bicuculline; Binding, Competitive; Carbolines; Cerebellum; Diazepam; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Male; Muscimol; Rats; Receptors, GABA-A; Spinal Cord; Synaptic Membranes | 1988 |
Benzodiazepines and barbiturate potentiate the pre- and postsynaptic gamma-aminobutyric acid (GABA)A receptor-mediated response in the enteric nervous system of guinea pig small intestine.
Topics: Acetylcholine; Animals; Barbiturates; Benzodiazepines; Clonazepam; Diazepam; Female; Flumazenil; Guinea Pigs; Intestine, Small; Male; Muscimol; Pentobarbital; Potassium; Receptors, GABA-A | 1988 |
Male scent-induced analgesia in the deer mouse, Peromyscus maniculatus: involvement of benzodiazepine systems.
Topics: Aggression; Analgesia; Animals; Diazepam; Female; Flumazenil; Male; Naloxone; Nociceptors; Peromyscus; Receptors, GABA-A; Smell | 1988 |
The effect of agonists at the GABA-benzodiazepine-receptor-complex on the proconflict effect induced by beta-CCM and pentetrazol in rats.
Topics: Aminooxyacetic Acid; Animals; Azabicyclo Compounds; Carbolines; Conflict, Psychological; Convulsants; Diazepam; Flumazenil; Hypnotics and Sedatives; Male; Pentylenetetrazole; Phenobarbital; Piperazines; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1988 |
The abstinence syndrome in diazepam-dependent cats is precipitated by Ro 15-1788 and Ro 15-4513 but not by the benzodiazepine receptor antagonist ZK 93426.
Topics: Animals; Azides; Benzodiazepines; Carbolines; Cats; Diazepam; Flumazenil; Receptors, GABA-A; Substance Withdrawal Syndrome | 1988 |
Involvement of the inhibitory GTP-binding regulatory protein and a low-affinity benzodiazepine receptor in the inhibitory effect of diazepam on rat brain adenylate cyclase system.
Topics: Adenylyl Cyclase Inhibitors; Animals; Brain; Bromides; Diazepam; Flumazenil; GTP-Binding Proteins; Guanylyl Imidodiphosphate; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptic Membranes | 1988 |
Modulation of the electrically evoked release of 5-[3H]hydroxytryptamine from rat cerebral cortex: effects of alpidem, CL 218872, and diazepam.
Topics: Animals; Benzodiazepines; Carbolines; Cerebral Cortex; Diazepam; Electric Stimulation; Flumazenil; gamma-Aminobutyric Acid; Imidazoles; Male; Monoamine Oxidase Inhibitors; Pargyline; Pyrazoles; Pyridazines; Pyridines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Serotonin | 1988 |
In vivo binding of (3H)Ro 15-1788 in mice: comparison with the in vivo binding of (3H)flunitrazepam.
Topics: Animals; Brain; Cerebellum; Cerebral Cortex; Diazepam; Flumazenil; Flunitrazepam; Hippocampus; Male; Mice; Receptors, GABA-A | 1988 |
Chronic administration of diazepam downregulates adenosine receptors in the rat brain.
Topics: Animals; Brain; Diazepam; Flumazenil; Flunitrazepam; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Purinergic | 1988 |
In vivo determination of the profile of benzodiazepine ligands by comparing the inhibition of 3H-Ro 15-1788 binding to the modulation of cGMP levels in mouse cerebellum.
Topics: Animals; Cerebellum; Cyclic GMP; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Ligands; Male; Mice; Naphthyridines; Piperazines; Receptors, GABA-A; Sulfur Compounds; Tritium | 1988 |
Involvement of GABAergic systems and benzodiazepine receptors in the jumping behavior induced by harmine and apomorphine in rats.
Topics: Alkaloids; Animals; Apomorphine; Brain; Diazepam; Flumazenil; Harmine; Hydroxydopamines; Male; Motor Activity; Muscimol; Oxidopamine; Pyridines; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1988 |
Effects of drugs on the electrical activity of the red nucleus in the rabbit. Activation of benzodiazepine and barbiturate receptors.
Topics: Animals; Bicuculline; Carbolines; Diazepam; Drug Interactions; Electroencephalography; Flumazenil; Muscle Relaxation; Pentobarbital; Pyridazines; Rabbits; Receptors, GABA-A; Receptors, Neurotransmitter; Red Nucleus | 1988 |
Animal models of chronic anxiety and "fearlessness".
Topics: Animals; Anxiety; Brain; Cats; Diazepam; Disease Models, Animal; Fear; Female; Flumazenil; Flunitrazepam; Male; Pregnancy; Prenatal Exposure Delayed Effects; Receptors, GABA-A | 1988 |
Chronic ethanol administration increases the binding of the benzodiazepine inverse agonist and alcohol antagonist [3H]RO15-4513 in rat brain.
Topics: Acoustic Stimulation; Animals; Azides; Benzodiazepines; Body Temperature; Brain Chemistry; Diazepam; Ethanol; Flumazenil; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1988 |
Partial reversal of ethanol-induced reductions in exploration by two benzodiazepine antagonists (flumazenil and ZK 93426).
Topics: Animals; Carbolines; Diazepam; Dose-Response Relationship, Drug; Ethanol; Exploratory Behavior; Flumazenil; Male; Mice; Receptors, GABA-A | 1988 |
Ro 15-4513: partial inverse agonism at the BZR and interaction with ethanol.
Topics: Animals; Azides; Behavior, Animal; Benzodiazepines; Brain; Brain Chemistry; Cats; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Electrophysiology; Ethanol; Flumazenil; Meta-Analysis as Topic; Mice; Phenobarbital; Rats; Receptors, GABA-A | 1988 |
Benzodiazepine antagonist Ro 15-1788 in self-poisoning. Diagnostic and therapeutic use.
Topics: Adult; Aged; Anti-Anxiety Agents; Antidotes; Benzodiazepinones; Coma; Diazepam; Electroencephalography; Female; Flumazenil; Flunitrazepam; Humans; Male; Middle Aged; Naloxone; Suicide, Attempted | 1985 |
Effects of repeated RO 15-1788 administration in benzodiazepine-dependent baboons.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Convulsants; Diazepam; Drug Tolerance; Flumazenil; Humans; Male; Papio; Posture; Substance Withdrawal Syndrome; Substance-Related Disorders; Tremor; Triazolam; Vomiting | 1985 |
Reversal of antinociceptive effect of cholecystokinin by benzodiazepines and a benzodiazepine antagonist, Ro 15-1788.
Topics: Analgesics; Animals; Anti-Anxiety Agents; Benzodiazepinones; Chlordiazepoxide; Cholecystokinin; Diazepam; Flumazenil; Flurazepam; Male; Mice; Morphine; Naloxone; Pain; Sensory Thresholds; Time Factors | 1985 |
ZK 91296, an anticonvulsant beta-carboline which lacks muscle relaxant properties.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepinones; Carbolines; Convulsants; Diazepam; Electromyography; Electroshock; Flumazenil; Indoles; Male; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle Relaxants, Central; Muscle Tonus; Phenobarbital; Rats; Rats, Inbred Strains | 1985 |
Benzodiazepines reduce the tolerance to reward delay in rats.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Choice Behavior; Diazepam; Flumazenil; Male; Piperidines; Rats; Rats, Inbred Strains; Reward; Serotonin Antagonists; Synaptic Transmission; Zimeldine | 1985 |
Specific antagonism by RO 15-1788 of benzodiazepine-induced increases in food intake in rhesus monkeys.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Bromazepam; Convulsants; Diazepam; Dose-Response Relationship, Drug; Feeding Behavior; Female; Flumazenil; Macaca mulatta; Male; Pentobarbital | 1985 |
Disruption of schedule-controlled behavior by Ro 15-1788 one day after acute treatment with benzodiazepines.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Chlordiazepoxide; Conditioning, Operant; Convulsants; Diazepam; Flumazenil; Male; Nordazepam; Reinforcement Schedule; Saimiri | 1986 |
Behavioral effects of zopiclone, CL 218,872 and diazepam in squirrel monkeys: antagonism by Ro 15-1788 and CGS 8216.
Topics: Animals; Anti-Anxiety Agents; Azabicyclo Compounds; Benzodiazepinones; Conditioning, Operant; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Male; Piperazines; Pyrazoles; Pyridazines; Saimiri | 1986 |
Behavioral studies with anxiolytic drugs. III. Antipunishment actions of buspirone in the pigeon do not involve benzodiazepine receptor mechanisms.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Buspirone; Chlordiazepoxide; Columbidae; Diazepam; Flumazenil; Flunitrazepam; Punishment; Pyrimidines; Receptors, GABA-A | 1986 |
A new method for screening anxiolytic drugs in rats.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Azabicyclo Compounds; Diazepam; Drug Evaluation, Preclinical; Flumazenil; Male; Models, Psychological; Piperazines; Rats; Rats, Inbred WKY | 1987 |
Effects of two benzodiazepines and a benzodiazepine antagonist on neuromuscular blockade in the anaesthetized cat.
Topics: Animals; Blood Pressure; Cats; Diazepam; Drug Interactions; Drug Synergism; Female; Flumazenil; Male; Midazolam; Neuromuscular Blocking Agents; Neuromuscular Junction; Pancuronium; Sciatic Nerve; Vecuronium Bromide | 1987 |
Interactions of aminophylline and three benzodiazepine compounds with amygdala-kindled seizures in rats.
Topics: Aminophylline; Amygdala; Animals; Anti-Anxiety Agents; Diazepam; Drug Interactions; Flumazenil; Kindling, Neurologic; Male; Pyrazoles; Rats; Rats, Inbred Strains; Seizures | 1987 |
Inhibition of non-dopamine cells in the ventral tegmental area by benzodiazepines: relationship to A10 dopamine cell activity.
Topics: Animals; Anti-Anxiety Agents; Diazepam; Flumazenil; Haloperidol; Iontophoresis; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Tegmentum Mesencephali | 1987 |
Tetrazepam: a benzodiazepine which dissociates sedation from other benzodiazepine activities. I. Psychopharmacological profile in rodents.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Diazepam; Feeding Behavior; Flumazenil; Male; Mice; Motor Activity; Pentylenetetrazole; Rats; Seizures | 1988 |
Continuous slow release of low levels of diazepam produces tolerance to its depressant and anxiolytic effects on the startle reflex.
Topics: Animals; Anti-Anxiety Agents; Brain; Conditioning, Operant; Depression, Chemical; Diazepam; Drug Implants; Drug Tolerance; Flumazenil; Male; Rats; Rats, Inbred Strains; Reflex, Startle | 1988 |
Modulation of GABA-stimulated chloride influx into membrane vesicles from rat cerebral cortex by benzodiazepines and nonbenzodiazepines.
Topics: Animals; Anti-Anxiety Agents; Cell Membrane; Cerebral Cortex; Chlorides; Clonazepam; Diazepam; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Rats; Rats, Inbred Strains | 1988 |
Controlled sedation in ventilated intensive care patients.
Topics: Adult; Aged; Anti-Anxiety Agents; Coma; Critical Care; Diazepam; Female; Flumazenil; Humans; Injections, Intravenous; Male; Middle Aged; Respiration, Artificial | 1988 |
Effects of non-sedative anxiolytic drugs on responses to GABA and on diazepam-induced enhancement of these responses on mouse neurones in cell culture.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Buspirone; Carbolines; Cells, Cultured; Convulsants; Diazepam; Electrophysiology; Flumazenil; gamma-Aminobutyric Acid; Mice; Neurons; Pyrazoles; Quinolines; Spinal Cord | 1988 |
Benzodiazepines for catatonic symptoms, stupor, and mutism.
Topics: Anti-Anxiety Agents; Benzodiazepines; Catatonia; Depressive Disorder; Diazepam; Female; Flumazenil; Humans; Lorazepam; Mutism | 1988 |
Discriminative-stimulus effects of midazolam in squirrel monkeys: comparison with other drugs and antagonism by Ro 15-1788.
Topics: Animals; Azabicyclo Compounds; Barbital; Benzodiazepines; Benzodiazepinones; Buspirone; Caffeine; Chlordiazepoxide; Cinanserin; Clozapine; Conditioning, Operant; Cyproheptadine; Diazepam; Diphenhydramine; Discrimination Learning; Electroshock; Flumazenil; Male; Midazolam; Muscimol; Nordazepam; Pentobarbital; Piperazines; Pyridazines; Pyrimidines; Saimiri; Tripelennamine | 1985 |
Effects of guanyl nucleotides on [3H]flunitrazepam binding to rat hippocampal synaptic membranes: equilibrium binding and dissociation kinetics.
Topics: Adenosine Triphosphate; Animals; Benzodiazepinones; Diazepam; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Guanine Nucleotides; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Hippocampus; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptic Membranes | 1985 |
Changes in the characteristics of low affinity GABA binding sites elicited by Ro15-1788.
Topics: Animals; Benzodiazepinones; Carbolines; Cerebral Cortex; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Handling, Psychological; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1985 |
Pharmacological and neurochemical properties of 1,4-diazepines with two annelated heterocycles ('hetrazepines').
Topics: Action Potentials; Aggression; Animals; Anticonvulsants; Azepines; Behavior, Animal; Benzodiazepinones; Brain Chemistry; Carbolines; Cerebral Cortex; Conflict, Psychological; Diazepam; Flumazenil; Heterocyclic Compounds; Humans; Hypnotics and Sedatives; Male; Mice; Motor Activity; Neurons; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sleep; Social Isolation; Wakefulness | 1985 |
Radiation inactivation studies of the benzodiazepine/gamma-aminobutyric acid/chloride ionophore receptor complex.
Topics: Animals; Barbiturates; Benzodiazepines; Benzodiazepinones; Binding Sites; Brain; Carbolines; Cell Membrane; Chlorides; Diazepam; Flumazenil; Flunitrazepam; Ionophores; Male; Molecular Weight; Muscimol; Picrotoxin; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1985 |
The effects of benzodiazepines on spinal homosynaptic depression.
Topics: Animals; Benzodiazepinones; Cats; Clonazepam; Diazepam; Female; Flumazenil; Male; Receptors, GABA-A; Reflex, Monosynaptic; Reflex, Stretch; Spinal Nerve Roots; Synapses | 1985 |
Blockade of the diazepam-induced increase in rat striatal acetylcholine content by the specific benzodiazepine antagonists ethyl-beta-carboline-3-carboxylate and Ro 15-1788.
Topics: Acetylcholine; Animals; Benzodiazepines; Benzodiazepinones; Brain Chemistry; Carbolines; Corpus Striatum; Diazepam; Female; Flumazenil; Indoles; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1985 |
Supraspinal convulsions induced by inverse benzodiazepine agonists in rabbits.
Topics: Animals; Benzodiazepinones; Carbolines; Diazepam; Electroencephalography; Flumazenil; Male; Pyrazoles; Rabbits; Receptors, GABA-A; Seizures | 1985 |
Benzodiazepines inhibit human platelet activation: comparison of the mechanism of antiplatelet actions of flurazepam and diazepam.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Benzodiazepinones; Blood Platelets; Collagen; Cyclic AMP; Cyclic GMP; Diazepam; Epinephrine; Flumazenil; Flurazepam; Humans; Malondialdehyde; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Serotonin; Thrombin; Type C Phospholipases | 1985 |
Reduction of inhibition by a benzodiazepine antagonist, Ro15-1788, in the rat hippocampal slice.
Topics: Animals; Benzodiazepinones; Chlordiazepoxide; Diazepam; Electric Conductivity; Evoked Potentials; Flumazenil; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Neural Inhibition; Rats; Synaptic Transmission | 1985 |
A beta-carboline antagonizes benzodiazepine actions but does not precipitate the abstinence syndrome in cats.
Topics: Animals; Behavior, Animal; Benzodiazepinones; Brain; Carbolines; Cats; Diazepam; Electroencephalography; Flumazenil; Humans; Indoles; Receptors, GABA-A; Substance Withdrawal Syndrome | 1985 |
Benzodiazepine-receptor mediated inhibition of isolation-induced aggression in mice.
Topics: Aggression; Animals; Benzodiazepinones; Carbolines; Diazepam; Flumazenil; Humans; Indoles; Male; Mice; Receptors, GABA-A; Social Isolation | 1985 |
Involvement of benzodiazepine recognition sites in the foot shock-induced decrease of low affinity GABA receptors in the rat cerebral cortex.
Topics: Animals; Benzodiazepinones; Cerebral Cortex; Diazepam; Electroshock; Flumazenil; Foot; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1985 |
Monoclonal antibodies to benzodiazepines.
Topics: Animals; Anti-Anxiety Agents; Antibodies, Monoclonal; Benzodiazepines; Benzodiazepinones; Diazepam; Flumazenil; Flunitrazepam; Flurazepam; Mice; Mice, Inbred BALB C; Receptors, GABA-A; Structure-Activity Relationship | 1985 |
Benzodiazepine binding characteristics of embryonic rat brain neurons grown in culture.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Brain; Carbolines; Cells, Cultured; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Flumazenil; gamma-Aminobutyric Acid; Neurons; Pyridazines; Rats; Receptors, GABA-A | 1985 |
Solubilization of peripheral benzodiazepine-binding sites from rat kidney.
Topics: Animals; Benzodiazepinones; Binding, Competitive; Carbolines; Chlordiazepoxide; Clonazepam; Diazepam; Digitonin; Flumazenil; Flurazepam; Guanidine; Guanidines; Hot Temperature; Isoquinolines; Kidney; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Solubility; Time Factors; Urea | 1985 |
Convulsant component of a depressant benzodiazepine.
Topics: Animals; Benzodiazepinones; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1985 |
Imaging of [11C]-labelled Ro 15-1788 binding to benzodiazepine receptors in the human brain by positron emission tomography.
Topics: Adult; Animals; Benzodiazepinones; Brain; Cerebral Cortex; Diazepam; Flumazenil; Humans; Kinetics; Macaca fascicularis; Male; Mental Disorders; Middle Aged; Receptors, GABA-A; Tomography, Emission-Computed | 1985 |
Attenuating effect of diazepam on stress-induced increases in noradrenaline turnover in specific brain regions of rats: antagonism by Ro 15-1788.
Topics: Animals; Behavior, Animal; Benzodiazepinones; Brain; Diazepam; Flumazenil; Male; Methoxyhydroxyphenylglycol; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, GABA-A; Restraint, Physical; Stress, Physiological; Tissue Distribution | 1985 |
Antianxiety effect of cannabis: involvement of central benzodiazepine receptors.
Topics: Adult; Aggression; Animals; Anxiety; Benzodiazepinones; Cannabinoids; Diazepam; Dronabinol; Electroshock; Female; Flumazenil; Frontal Lobe; Humans; Male; Mice; Mice, Inbred Strains; Middle Aged; Receptors, GABA-A; Tritium | 1986 |
Enhancement of GABA binding by the benzodiazepine partial agonist CGS9896.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Brain; Calcium Chloride; Diazepam; Flumazenil; gamma-Aminobutyric Acid; In Vitro Techniques; Magnesium; Pyrazoles; Pyridazines; Rats; Receptors, GABA-A | 1985 |
The benzodiazepine antagonist Ro 15-1788 does not antagonize the ethanol withdrawal syndrome.
Topics: Animals; Arousal; Benzodiazepinones; Brain; Diazepam; Drug Therapy, Combination; Ethanol; Flumazenil; Male; Motor Skills; Rats; Rats, Inbred Strains; Receptors, GABA-A; Substance Withdrawal Syndrome | 1986 |
Differential antagonism of diazepam-induced loss of the righting response.
Topics: Animals; Benzodiazepinones; Carbolines; Columbidae; Diazepam; Flumazenil; Inosine; Male; Pentobarbital; Posture; Receptors, GABA-A; Reflex; Saimiri | 1986 |
Benzodiazepine receptor involvement in the control of receptive field size and responsiveness in primary somatosensory cortex.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Cats; Diazepam; Female; Flumazenil; Flurazepam; gamma-Aminobutyric Acid; Male; Midazolam; Neurons; Receptors, GABA-A; Sensory Thresholds; Somatosensory Cortex; Touch | 1986 |
Convulsant effect of Ro 5-4864, a peripheral type benzodiazepine, on the baboon (Papio papio).
Topics: Animals; Benzodiazepines; Benzodiazepinones; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Isoquinolines; Papio; Receptors, GABA-A; Seizures | 1986 |
Proconflict effect of GABA receptor complex antagonists. Reversal by diazepam.
Topics: Animals; Benzodiazepinones; Bicuculline; Conflict, Psychological; Diazepam; Flumazenil; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1986 |
The possible role of benzodiazepine receptors in morphine analgesia.
Topics: Animals; Benzodiazepinones; Diazepam; Drug Interactions; Flumazenil; Male; Mice; Morphine; Pain; Receptors, GABA-A | 1986 |
Effects of beta-carboline-3-carboxylic acid ethyl ester on suppressed and non-suppressed responding in the rhesus monkey.
Topics: Adrenocorticotropic Hormone; Animals; Blood Pressure; Carbolines; Conditioning, Operant; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Heart Rate; Macaca mulatta; Male; Punishment; Reinforcement Schedule | 1986 |
Apparent pA2 estimation of benzodiazepine receptor antagonists.
Topics: Animals; Diazepam; Drug Interactions; Female; Flumazenil; Male; Pentylenetetrazole; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1986 |
Benzodiazepines inhibit thyrotropin (TSH)-releasing hormone-induced TSH and growth hormone release from perifused rat pituitaries.
Topics: Animals; Benzodiazepines; Bicuculline; Diazepam; Flumazenil; Growth Hormone; Growth Hormone-Releasing Hormone; In Vitro Techniques; Isoquinolines; Male; Picrotoxin; Pituitary Gland, Anterior; Rats; Receptors, GABA-A; Secretory Rate; Thyrotropin; Thyrotropin-Releasing Hormone | 1986 |
The possible modulation of morphine analgesia by the supramolecular GABA receptor complex.
Topics: Analgesics; Animals; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Male; Mice; Morphine; Picrotoxin; Receptors, GABA-A | 1986 |
A 7-phenyl substituted triazolopyridazine has inverse agonist activity at the benzodiazepine receptor site.
Topics: Animals; Binding, Competitive; Brain; Conditioning, Operant; Convulsants; Diazepam; Female; Flumazenil; Flunitrazepam; In Vitro Techniques; Male; Mice; Pyridazines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Structure-Activity Relationship | 1987 |
The beta-carboline ZK 93423 inhibits reticulata neurons: an effect reversed by benzodiazepine antagonists.
Topics: Action Potentials; Animals; Carbolines; Diazepam; Flumazenil; Male; Neurons; Rats; Rats, Inbred Strains; Receptors, GABA-A; Substantia Nigra | 1987 |
Dissimilarities between benzodiazepine-binding sites and adenosine uptake sites in astrocytes and neurons in primary cultures.
Topics: Adenosine; Animals; Astrocytes; Benzodiazepines; Binding Sites; Cells, Cultured; Diazepam; Flumazenil; Isoquinolines; Neurons; Pyrazoles; Receptors, GABA-A | 1987 |
Separation distress in infant rhesus monkeys: effects of diazepam and Ro 15-1788.
Topics: Adrenocorticotropic Hormone; Animals; Animals, Newborn; Anxiety, Separation; Behavior, Animal; Diazepam; Female; Flumazenil; Hydrocortisone; Macaca mulatta; Male; Maternal Deprivation; Vocalization, Animal | 1987 |
CGS 9896 and ZK 91296, but not CGS 8216 and RO 15-1788, are pure benzodiazepine receptor antagonists on mouse neurons in culture.
Topics: Animals; Brain; Carbolines; Cells, Cultured; Diazepam; Electrophysiology; Flumazenil; gamma-Aminobutyric Acid; Mice; Neurons; Pyrazoles; Receptors, GABA-A; Spinal Cord | 1987 |
Interactions of Ro 15-1788, CGS 8216 and diazepam on head-turning in rats.
Topics: Animals; Benzodiazepinones; Diazepam; Drug Interactions; Electric Stimulation; Flumazenil; Head; Male; Movement; Muscimol; Pyrazoles; Rats; Rats, Inbred Strains | 1986 |
Diazepam potentiates GABA-contraction in guinea-pig ileum.
Topics: Animals; Baclofen; Benzodiazepinones; Carbolines; Diazepam; Drug Synergism; Electric Stimulation; Flumazenil; gamma-Aminobutyric Acid; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth | 1986 |
Acute tolerance to diazepam induced by benzodiazepines.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Flumazenil; Lorazepam; Male; Mice; Sleep | 1986 |
Effects of diazepam on pancreatic exocrine secretion in the dog.
Topics: Animals; Benzodiazepinones; Bicarbonates; Diazepam; Dogs; Female; Flumazenil; Male; Pancreas; Pancreatic Juice; Proteins; Regional Blood Flow; Secretin | 1986 |
Diazepam-induced decrease in histamine turnover in mouse brain.
Topics: Animals; Benzodiazepinones; Brain; Diazepam; Drug Interactions; Flumazenil; Histamine; Male; Methylhistamines; Mice; Muscimol; Pargyline | 1986 |
Reversal of the effect of centrally-administered diazepam on morphine antinociception by specific (Ro 15-1788 and Ro 15-3505) and non-specific (bicuculline and caffeine) benzodiazepine antagonists.
Topics: Animals; Benzodiazepinones; Bicuculline; Caffeine; Diazepam; Flumazenil; Injections, Intraventricular; Male; Morphine; Pain; Rats; Rats, Inbred Strains | 1986 |
Reversal of the cerebral effects of diazepam in the dog by the benzodiazepine antagonist Ro15-1788.
Topics: Anesthesia; Animals; Benzodiazepinones; Brain; Cerebrovascular Circulation; Diazepam; Dogs; Electroencephalography; Female; Flumazenil; Male; Nitrous Oxide; Oxygen | 1986 |
Benzodiazepine antagonist, CGS-8216, in diazepam- or pentobarbital-dependent and non-dependent rats.
Topics: Animals; Arousal; Diazepam; Dose-Response Relationship, Drug; Female; Flumazenil; Pentobarbital; Pyrazoles; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Substance-Related Disorders | 1986 |
Effect of RO 15-1788 on diazepam, GABA & pentobarbitone induced EEG changes in rabbits.
Topics: Animals; Cerebral Cortex; Diazepam; Electroencephalography; Electromyography; Female; Flumazenil; gamma-Aminobutyric Acid; Male; Pentobarbital; Rabbits | 1986 |
CGS 8216: agonist and diazepam-antagonist effects in rodents.
Topics: Animals; Ataxia; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Flumazenil; Male; Mice; Pentylenetetrazole; Pyrazoles; Rats; Rats, Inbred F344; Reinforcement, Psychology | 1986 |
Evaluation of two anticonvulsant amino-pyridazine derivatives in the conflict test in rats.
Topics: Animals; Anticonvulsants; Conflict, Psychological; Diazepam; Flumazenil; Meprobamate; Mice; Papio; Pentobarbital; Pyrazoles; Pyridazines; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Valproic Acid | 1986 |
Investigation of the actions of the benzodiazepine antagonists Ro 15-1788 and CGS 8216 using the schedule-controlled behavior of rats.
Topics: Animals; Anxiety; Behavior, Animal; Benzodiazepines; Diazepam; Drug Interactions; Flumazenil; Male; Pyrazoles; Pyridines; Rats; Rats, Inbred Strains; Zolpidem | 1986 |
Effects of the benzodiazepine antagonists RO 15-1788, CGS-8216 and PK-11195 on amygdaloid kindled seizures and the anticonvulsant efficacy of diazepam.
Topics: Amygdala; Animals; Diazepam; Flumazenil; Isoquinolines; Kindling, Neurologic; Male; Pyrazoles; Rats; Rats, Inbred Strains | 1986 |
Diazepam-sensitive specific binding of phenytoin in rat brain.
Topics: Animals; Benzodiazepinones; Binding Sites; Cell Membrane; Cerebral Cortex; Clonazepam; Diazepam; Flumazenil; Male; Phenytoin; Rats; Rats, Inbred Strains | 1986 |
Periodic benzodiazepine antagonist administration prevents benzodiazepine withdrawal symptoms in primates.
Topics: Animals; Behavior, Animal; Body Weight; Diazepam; Drug Administration Schedule; Flumazenil; Macaca mulatta; Substance Withdrawal Syndrome | 1986 |
Benzodiazepine ligands, nociception and 'defeat' analgesia in male mice.
Topics: Analgesia; Animals; Appetite Depressants; Benzodiazepines; Carbolines; Chlordiazepoxide; Diazepam; Flumazenil; Male; Mice; Mice, Inbred DBA; Nociceptors; Pyrazoles | 1987 |
Lack of withdrawal signs of dependence following cessation of treatment or Ro-15,1788 administration to rats chronically treated with buspirone.
Topics: Animals; Body Weight; Buspirone; Diazepam; Flumazenil; Food Deprivation; Male; Pyrimidines; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1986 |
Characterization of the analgesic effects of the benzodiazepine antagonist, Ro 15-1788.
Topics: Analgesics; Animals; Diazepam; Flumazenil; Male; Naloxone; Rats; Rats, Inbred Strains | 1987 |
Social conflict analgesia: inhibition of early non-opioid component by diazepam or flumazepil fails to affect appearance of late opioid component.
Topics: Aggression; Animals; Appetitive Behavior; Conflict, Psychological; Diazepam; Endorphins; Flumazenil; Male; Mice; Mice, Inbred DBA; Pain; Predatory Behavior; Reaction Time | 1987 |
Benzodiazepine antagonist Ro 15-1788 (flumazepil) attenuates the anticonvulsant activity of diazepam in epileptic fowl.
Topics: Animals; Chickens; Diazepam; Epilepsy; Female; Flumazenil; Male; Poultry Diseases | 1987 |
Diazepam and endorphin independently inhibit ultrasonic distress calls in rats.
Topics: Animals; Convulsants; Depression, Chemical; Diazepam; Endorphins; Flumazenil; Injections, Subcutaneous; Male; Pyrazoles; Rats; Rats, Inbred Strains; Ultrasonics; Vocalization, Animal | 1987 |
Effects of Ro 15-1788 and CGS 8216 in diazepam-dependent baboons.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Male; Papio; Pyrazoles; Substance Withdrawal Syndrome; Substance-Related Disorders | 1987 |
Effects of diazepam, ethanol and Ro 15-1788 on ultrasonic vocalization, locomotor activity and body righting in the neonatal rat.
Topics: Animals; Animals, Newborn; Diazepam; Dose-Response Relationship, Drug; Ethanol; Flumazenil; Motor Activity; Posture; Rats; Rats, Inbred Strains; Reflex; Ultrasonics; Vocalization, Animal | 1987 |
Enhancement of a diazepam withdrawal symptom by bicuculline and yohimbine.
Topics: Animals; Bicuculline; Diazepam; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Flumazenil; Male; Rats; Substance Withdrawal Syndrome; Yohimbine | 1987 |
Effects of diazepam, FG 7142, and RO 15-1788 on schedule-induced polydipsia and the temporal control of behavior.
Topics: Animals; Appetite Depressants; Carbolines; Diazepam; Drinking Behavior; Flumazenil; Male; Motor Activity; Rats | 1988 |
Precipitation of abstinence in nordiazepam- and diazepam-dependent dogs.
Topics: Analysis of Variance; Animals; Diazepam; Dogs; Flumazenil; Nordazepam; Oxazepam; Pyrazoles; Seizures; Substance Withdrawal Syndrome; Substance-Related Disorders | 1988 |
Stimulatory action of gamma-aminobutyric acid on catecholamine secretion from bovine adrenal chromaffin cells measured by a real-time monitoring system.
Topics: Adrenal Glands; Animals; Catecholamines; Cattle; Chromaffin System; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Magnesium; Nifedipine | 1988 |
Inhibition of cell proliferation of human gliomas by benzodiazepines in vitro.
Topics: Astrocytoma; Benzodiazepines; Benzodiazepinones; Cell Division; Clonazepam; Diazepam; Female; Flumazenil; Glioma; Humans; Male; Middle Aged; Thymidine; Tumor Cells, Cultured | 1988 |
Treatment of severe chloroquine poisoning.
Topics: Animals; Chloroquine; Diazepam; Epinephrine; Flumazenil; Gastric Lavage; Humans; Respiration, Artificial | 1988 |
Modulation of GABA-gated chloride ion flux in rat brain by acute and chronic benzodiazepine administration.
Topics: Animals; Benzodiazepines; Brain; Chlorides; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Flurazepam; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred Strains | 1988 |
Ultrasonic vocalization in response to unavoidable aversive stimuli in rats: effects of benzodiazepines.
Topics: Alprazolam; Animals; Benzodiazepines; Desipramine; Diazepam; Electroshock; Flumazenil; Haloperidol; Male; Rats; Rats, Inbred Strains; Ultrasonics; Vocalization, Animal | 1988 |
Distinctive behavioral effects of the pyrazoloquinoline CGS 8216 in squirrel monkeys.
Topics: Animals; Behavior, Animal; Benzodiazepines; Clonidine; Diazepam; Flumazenil; Male; Pyrazoles; Saimiri | 1988 |
A simple and rapid method of inducing physical dependence with benzodiazepines in mice.
Topics: Animals; Benzodiazepines; Diazepam; Flumazenil; Injections, Intraperitoneal; Male; Mice; Mice, Inbred Strains; Substance Withdrawal Syndrome; Substance-Related Disorders | 1988 |
The effects of chronic antidepressant treatment in an animal model of anxiety.
Topics: Amitriptyline; Animals; Antidepressive Agents; Anxiety; Desipramine; Diazepam; Disease Models, Animal; Flumazenil; Male; Rats; Time Factors | 1988 |
Reversal of iatrogenic diazepam overdose with flumazenil.
Topics: Aged; Coma; Diazepam; Flumazenil; Humans; Intensive Care Units; Male | 1988 |
The lateral vestibular nucleus is a site for the depressant action of benzodiazepines on the crossed extensor reflex.
Topics: Action Potentials; Animals; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Flurazepam; Male; Microinjections; Neural Inhibition; Posture; Rats; Rats, Inbred Strains; Reflex; Vestibular Nuclei | 1988 |
Brief exposure to a natural predator, the short-tailed weasel, induces benzodiazepine-sensitive analgesia in white-footed mice.
Topics: Analgesia; Animals; Appetitive Behavior; Diazepam; Flumazenil; Handling, Psychological; Hot Temperature; Male; Naloxone; Pain; Peromyscus; Predatory Behavior; Rabbits; Reference Values; Rodentia | 1988 |
Theophylline antagonizes the effect of diazepam on ventricular automaticity.
Topics: Adenosine; Animals; Diazepam; Female; Flumazenil; Heart Rate; Heart Ventricles; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Theophylline; Ventricular Function | 1988 |
Effects of Ro 15-4513, alone or in combination with ethanol, Ro 15-1788, diazepam, and pentobarbital on instrumental behaviors of rats.
Topics: Animals; Azides; Behavior, Animal; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Female; Flumazenil; Pentobarbital; Rats; Rats, Inbred Strains; Time Factors | 1988 |
Withdrawal from diazepam substitutes for the discriminative stimulus properties of pentylenetetrazol.
Topics: Animals; Diazepam; Discrimination Learning; Disease Models, Animal; Flumazenil; Male; Pentylenetetrazole; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 1988 |
Blood pressure response to Ro15-1788, a benzodiazepine antagonist.
Topics: Animals; Benzodiazepinones; Blood Pressure; Cats; Convulsants; Diazepam; Drug Tolerance; Flumazenil; Flurazepam; Heart Rate; Humans; Substance-Related Disorders | 1985 |
Precipitated diazepam withdrawal elevates noradrenergic metabolism in primate brain.
Topics: Animals; Behavior, Animal; Benzodiazepinones; Brain; Chlorocebus aethiops; Diazepam; Female; Flumazenil; Humans; Male; Methoxyhydroxyphenylglycol; Narcotics; Norepinephrine; Substance Withdrawal Syndrome | 1985 |
An EEG investigation on the role of cerebello-rubral system in the effects of diazepam and pentobarbital.
Topics: Animals; Benzodiazepinones; Cerebellum; Diazepam; Electroencephalography; Female; Flumazenil; Male; Pentobarbital; Pentylenetetrazole; Picrotoxin; Rabbits; Red Nucleus | 1985 |
Evaluation of the muscle relaxant properties of a novel beta-carboline, ZK 93423 in rats and cats.
Topics: Animals; Benzodiazepinones; Carbolines; Cats; Decerebrate State; Diazepam; Electromyography; Evoked Potentials; Female; Flumazenil; Male; Muscle Relaxants, Central; Neurons, Afferent; Rats; Rats, Mutant Strains; Reflex; Species Specificity; Time Factors | 1985 |
[Effect of the beta-carboline derivative FG 7142 on inhibition in hippocampal sections].
Topics: Animals; Benzodiazepinones; Carbolines; Diazepam; Electric Stimulation; Evoked Potentials; Flumazenil; Hippocampus; Neural Inhibition; Neurons; Rats; Rats, Inbred Strains | 1985 |
Specific changes in local cerebral glucose utilization in the rat brain induced by acute and chronic diazepam.
Topics: Animals; Benzodiazepinones; Brain; Diazepam; Flumazenil; Glucose; Male; Rats; Rats, Inbred Strains; Time Factors | 1985 |
Diazepam increases membrane fluidity of rat hippocampus synaptosomes.
Topics: Animals; Benzodiazepinones; Cerebellum; Diazepam; Flumazenil; Hippocampus; Male; Membrane Fluidity; Rats; Receptors, Cell Surface; Receptors, GABA-A; Synaptosomes | 1984 |
In vitro interaction of premazepam with benzodiazepine receptors in rat brain regions.
Topics: Animals; Azepines; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Brain; Cerebellum; Convulsants; Diazepam; Flumazenil; Flunitrazepam; Kinetics; Male; Organ Specificity; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Synaptosomes; Thermodynamics | 1984 |
Electrophysiological and pharmacological characterization of peripheral benzodiazepine receptors in a guinea pig heart preparation.
Topics: Action Potentials; Animals; Benzodiazepinones; Clonazepam; Convulsants; Diazepam; Dose-Response Relationship, Drug; Electric Stimulation; Flumazenil; Guinea Pigs; Heart; In Vitro Techniques; Isoquinolines; Myocardial Contraction; Myocardium; Receptors, Cell Surface; Receptors, GABA-A | 1984 |
Evaluation of the beta-carboline ZK 93 426 as a benzodiazepine receptor antagonist.
Topics: Animals; Anticonvulsants; Ataxia; Benzodiazepinones; Binding, Competitive; Carbolines; Diazepam; Discrimination, Psychological; Drinking; Exploratory Behavior; Flumazenil; gamma-Aminobutyric Acid; In Vitro Techniques; Indoles; Mice; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Neurotransmitter; Sleep | 1984 |
An imidazodiazepine derivative, Ro 15-1788, behaves as a weak partial agonist in the crossed extensor reflex.
Topics: Animals; Benzodiazepinones; Carbolines; Chlorpromazine; Diazepam; Flumazenil; Male; Phenobarbital; Rats; Rats, Inbred Strains; Receptors, GABA-A; Reflex | 1984 |
Beta-carboline kindling of the benzodiazepine receptor.
Topics: Animals; Benzodiazepinones; Carbolines; Convulsants; Diazepam; Flumazenil; Indoles; Kindling, Neurologic; Pyridazines; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1984 |
Pharmacological evidence that PK 8165 behaves as a partial agonist of brain type benzodiazepine receptors.
Topics: Aggression; Animals; Anticonvulsants; Benzodiazepinones; Conflict, Psychological; Diazepam; Drinking; Flumazenil; Humans; Male; Mice; Mice, Inbred Strains; Phenobarbital; Quinolines; Receptors, GABA-A; Reflex | 1984 |
The benzodiazepine receptor and sleep.
Topics: Animals; Barbiturates; Benzodiazepines; Benzodiazepinones; Calcium; Carbolines; Diazepam; Flumazenil; Flurazepam; Humans; Motor Activity; Nifedipine; Phenobarbital; Pyrazoles; Rats; Receptors, GABA-A; Sleep; Synaptosomes | 1984 |
Benzodiazepine agonist-type activity of raubasine, a rauwolfia serpentina alkaloid.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Binding, Competitive; Brain; Diazepam; Flumazenil; Flurazepam; In Vitro Techniques; Kinetics; Male; Mice; Rats; Receptors, GABA-A; Secologanin Tryptamine Alkaloids; Yohimbine | 1984 |
Benzodiazepine binding sites in human pineal gland.
Topics: Adolescent; Adult; Aged; Animals; Benzodiazepinones; Binding, Competitive; Cerebral Cortex; Child; Child, Preschool; Clonazepam; Diazepam; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Humans; In Vitro Techniques; Infant; Kinetics; Male; Middle Aged; Pineal Gland; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1984 |
Scopolamine-induced locomotor stimulation in mice: effect of diazepam and a benzodiazepine antagonist.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Diazepam; Flumazenil; Male; Mice; Mice, Inbred BALB C; Motor Activity; Scopolamine | 1982 |
Comparison of the kinetics of [3H]diazepam and [3H]flunitrazepam binding to cortical synaptosomal membranes.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Cerebral Cortex; Diazepam; Filtration; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Male; Pentobarbital; Rats; Rats, Inbred Strains; Sodium Chloride; Synaptic Membranes | 1982 |
RO 15-1788 selectively reverses antagonism of pentylenetetrazol-induced discriminative stimuli by benzodiazepines but not by barbiturates.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Barbiturates; Benzodiazepines; Benzodiazepinones; Diazepam; Flumazenil; Male; Pentobarbital; Pentylenetetrazole; Rats; Stimulation, Chemical | 1982 |
Lorazepam and pentobarbital drug discrimination in baboons: cross-drug generalization and interaction with Ro 15-1788.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Flumazenil; Generalization, Response; Lorazepam; Male; Papio; Pentobarbital | 1983 |
Benzodiazepine selectively antagonize kainate-induced activation in the rat hippocampus.
Topics: Acetylcholine; Animals; Anti-Anxiety Agents; Benzodiazepinones; Chlorpromazine; Diazepam; Flumazenil; Glutamates; Hippocampus; Injections, Intravenous; Iontophoresis; Kainic Acid; Lorazepam; Male; Phenobarbital; Pyramidal Tracts; Pyrrolidines; Rats; Rats, Inbred Strains | 1983 |
Benzodiazepine receptor ligands with opposing pharmacologic actions.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Diazepam; Flumazenil; Flunitrazepam; Kinetics; Ligands; Membranes; Models, Psychological; Pyrazoles; Rats; Receptors, Cell Surface; Receptors, GABA-A; Temperature | 1983 |
Behavioral and EEG effects of benzodiazepines and their antagonists in the cat.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Carbolines; Cats; Diazepam; Electroencephalography; Flumazenil | 1983 |
Anxiolytic-like properties of fominoben.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Diazepam; Flumazenil; Male; Mice; Mice, Inbred C57BL; Morpholines | 1984 |
Benzodiazepine Ro 15-1788: electrophysiological evidence for partial agonist activity.
Topics: Animals; Benzodiazepinones; Culture Techniques; Diazepam; Dose-Response Relationship, Drug; Flumazenil; gamma-Aminobutyric Acid; Ganglia, Spinal; Glutamates; Glutamic Acid; Membrane Potentials; Mice; Neurons; Receptors, Cell Surface; Receptors, GABA-A; Spinal Cord; Synaptic Transmission | 1983 |
Benzodiazepine receptor antagonists reverse the effect of diazepam on plasma corticosterone in stressed rats.
Topics: Animals; Benzodiazepinones; Corticosterone; Diazepam; Flumazenil; Male; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Stress, Physiological | 1984 |
Differential effects of the benzodiazepine antagonist Ro 15-1788 after "general anaesthetic" doses of benzodiazepines in mice.
Topics: Anesthesia, General; Anesthetics; Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Chlordiazepoxide; Convulsants; Diazepam; Flumazenil; Flurazepam; Male; Mice; Mice, Inbred Strains; Midazolam; Reflex | 1984 |
The effects of GABA and benzodiazepine receptor antagonists on the anti-conflict actions of diazepam or ethanol.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Bicuculline; Conflict, Psychological; Diazepam; Dose-Response Relationship, Drug; Ethanol; Flumazenil; Male; Picrotoxin; Punishment; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1984 |
Self-injection of diazepam in naive rats: effects of dose, schedule and blockade of different receptors.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Bicuculline; Diazepam; Dose-Response Relationship, Drug; Extinction, Psychological; Flumazenil; Haloperidol; Male; Naloxone; Rats; Receptors, Drug; Reinforcement Schedule; Self Administration | 1984 |
Comparison of five preanesthetic medicaments in thiopental-anesthetized cats: antagonism by selected compounds.
Topics: 4-Aminopyridine; Acepromazine; Aminopyridines; Anesthesia, General; Animals; Arousal; Benzodiazepinones; Cats; Central Nervous System Stimulants; Convulsants; Diazepam; Drug Antagonism; Female; Flumazenil; Ketamine; Male; Meperidine; Naloxone; Pentobarbital; Preanesthetic Medication; Sodium Chloride; Xylazine; Yohimbine | 1984 |
Modification of seizures elicited by the benzodiazepine Ro 5-3663--a comparison with picrotoxin.
Topics: Animals; Benzodiazepinones; Chemical Phenomena; Chemistry; Convulsants; Diazepam; Drug Synergism; Flumazenil; Male; Mice; Picrotoxin; Pyrazoles; Quinolines; Seizures | 1984 |
Benzodiazepine antagonist Ro 15-1788: binding characteristics and interaction with drug-induced changes in dopamine turnover and cerebellar cGMP levels.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Brain; Cerebellum; Cerebral Cortex; Cyclic GMP; Diazepam; Dopamine; Flumazenil; Flunitrazepam; Kinetics; Mice; Receptors, Drug; Receptors, GABA-A | 1981 |
Reversal of the antiaversive and anticonvulsant actions of diazepam, but not of progabide, by a selective antagonist of benzodiazepine receptors.
Topics: Animals; Anxiety; Benzodiazepinones; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Humans; Rats; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Receptors, Neurotransmitter; Seizures | 1981 |
Caerulein and cholecystokinin octapeptide (CCK-8): sedative and anticonvulsive effects in mice unaffected by the benzodiazepine antagonist Ro 15-1788.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Blepharoptosis; Body Temperature; Ceruletide; Cholecystokinin; Diazepam; Flumazenil; Harmine; Hypnotics and Sedatives; Male; Mice; Peptide Fragments; Seizures; Sincalide | 1982 |
Benzodiazepine antagonists abolish electrophysiological effects of sodium valproate in the rat.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Diazepam; Evoked Potentials, Visual; Female; Flumazenil; gamma-Aminobutyric Acid; Immobilization; Kinetics; Male; Rats; Receptors, Drug; Receptors, GABA-A; Valproic Acid | 1982 |
Precipitated withdrawal by a benzodiazepine receptor antagonist (Ro 15-1788) after 7 days of diazepam.
Topics: Animals; Benzodiazepinones; Diazepam; Flumazenil; Humans; Male; Papio; Receptors, Drug; Receptors, GABA-A; Receptors, Neurotransmitter; Substance Withdrawal Syndrome; Time Factors | 1982 |
Anxiogenic and non-anxiogenic benzodiazepine antagonists.
Topics: Animals; Anxiety; Benzodiazepines; Benzodiazepinones; Carbolines; Diazepam; Flumazenil; Food Deprivation; Humans; Indoles; Mice; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Using Ro 15-1788 to investigate the benzodiazepine receptor in vivo: studies on the anticonvulsant and sedative effect of melatonin and the convulsant effect of the benzodiazepine Ro 05-3663.
Topics: Animals; Arousal; Benzodiazepinones; Brain; Diazepam; Dose-Response Relationship, Drug; Exploratory Behavior; Flumazenil; Male; Melatonin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1982 |
Purines interact with 'central' but not 'peripheral' benzodiazepine binding sites.
Topics: Animals; Benzodiazepinones; Binding, Competitive; Brain; Diazepam; Flumazenil; Purines; Rats; Receptors, Cell Surface; Receptors, GABA-A; Synaptosomes | 1982 |
Is the muscle relaxant effect of diazepam in spastic mutant rats mediated through GABA-independent benzodiazepine receptors?
Topics: Animals; Benzodiazepinones; Bicuculline; Diazepam; Electromyography; Female; Flumazenil; Male; Muscle Contraction; Muscle Relaxation; Picrotoxin; Rats; Rats, Mutant Strains; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Contrasting effects of ethyl beta-carboline-3-carboxylate (beta CCE) and diazepam on cerebellar cyclic GMP content and antagonism of both effects by Ro 15-1788, a specific benzodiazepine receptor blocker.
Topics: Animals; Benzodiazepinones; Carbolines; Cerebellum; Cyclic GMP; Diazepam; Flumazenil; In Vitro Techniques; Indoles; Isoniazid; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Is Ro15-1788 a partial agonist at benzodiazepine receptors?
Topics: Animals; Benzodiazepinones; Bicuculline; Convulsants; Diazepam; Flumazenil; Male; Mice; Mice, Inbred C3H; Phenobarbital; Pyridazines; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Increase of cyclic GMP in cerebellum by methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM).
Topics: Animals; Benzodiazepinones; Carbolines; Cerebellar Cortex; Cyclic GMP; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Indoles; Male; Muscimol; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Stimulation, Chemical | 1983 |
Diazepam receptor in frog muscle fibres.
Topics: Animals; Anura; Benzodiazepinones; Diazepam; Flumazenil; Muscle Contraction; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Diazepam, pentobarbital and D-etomidate produced increases in bicuculline seizure threshold; selective antagonism by RO15-1788, picrotoxin and (+/-)-DMBB.
Topics: Animals; Barbiturates; Benzodiazepinones; Bicuculline; Diazepam; Etomidate; Flumazenil; Imidazoles; Male; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1983 |
beta-Carbolines activate neurons in the substantia nigra pars reticulata: an effect reversed by diazepam and Ro15-1788.
Topics: Animals; Benzodiazepinones; Carbolines; Diazepam; Drug Interactions; Flumazenil; Indoles; Injections, Intravenous; Male; Rats; Rats, Inbred Strains; Substantia Nigra; Synaptic Transmission | 1983 |
Evidence for distinct benzodiazepine receptors for anticonvulsant and sedative actions: implications for the treatment of temporal lobe epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Benzodiazepinones; Diazepam; Epilepsy, Temporal Lobe; Flumazenil; Kindling, Neurologic; Pyrazoles; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
The benzodiazepine agonist diazepam inhibits basal and secretagogue-stimulated prolactin release in vitro.
Topics: Animals; Benzodiazepinones; Calcimycin; Cells, Cultured; Cyclic AMP; Diazepam; Drug Interactions; Female; Flumazenil; In Vitro Techniques; Male; Muscimol; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Inbred Strains; Thyrotropin | 1984 |
The action of stress, beta-carbolines, diazepam, and Ro 15-1788 on GABA receptors in the rat brain.
Topics: Animals; Benzodiazepinones; Brain; Brain Chemistry; Carbolines; Diazepam; Electroshock; Flumazenil; Handling, Psychological; Humans; Indoles; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Stress, Psychological; Synaptic Transmission | 1983 |
Involvement of GABA in the facilitation of punishment suppressed behavior induced by beta-carbolines in rat.
Topics: Animals; Anxiety; Benzodiazepinones; Carbolines; Conditioning, Operant; Diazepam; Drug Interactions; Flumazenil; gamma-Aminobutyric Acid; Humans; Indoles; Models, Psychological; Punishment; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Benzodiazepines receptor binding in vivo: pharmacokinetic and pharmacological significance.
Topics: Adrenal Glands; Animals; Benzodiazepinones; Brain; Carbolines; Corticosterone; Diazepam; Flumazenil; Flunitrazepam; Kinetics; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Effect of agonists, inverse agonists, and antagonists of benzodiazepine receptors on the firing rate of substantia nigra pars reticulata neurons.
Topics: Animals; Benzodiazepinones; Carbolines; Diazepam; Electrophysiology; Flumazenil; Male; Neurons; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Substantia Nigra | 1983 |
On the convulsant action of Ro 5-4864 and the existence of a micromolar benzodiazepine binding site in rat brain.
Topics: Animals; Benzodiazepinones; Binding Sites; Brain; Convulsants; Diazepam; Electroshock; Flumazenil; Male; Mice; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1984 |
Changes in benzodiazepine receptors by acute stress: different effect of chronic diazepam or RO 15-1788 treatment.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Cerebral Cortex; Diazepam; Female; Flumazenil; Flunitrazepam; Hippocampus; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Neurotransmitter; Stress, Physiological | 1983 |
A benzodiazepine antagonist action of CL 218,872.
Topics: Animals; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Convulsants; Diazepam; Flumazenil; Male; Mice; Mice, Inbred C57BL; Pyridazines; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1984 |
Ro 15-1788 and beta-CCE selectively eliminate diazepam-induced feeding in the rabbit.
Topics: Animals; Benzodiazepinones; Carbolines; Chlorpromazine; Cyproheptadine; Diazepam; Eating; Flumazenil; Indoles; Rabbits; Receptors, Cell Surface; Receptors, GABA-A; Water Deprivation | 1984 |
Benzodiazepine inhibition of adenosine uptake is not prevented by benzodiazepine antagonists.
Topics: Adenosine; Animals; Benzodiazepines; Benzodiazepinones; Brain; Diazepam; Flumazenil; Flurazepam; Hexobendine; In Vitro Techniques; Pyrazoles; Rats; Rats, Inbred Strains; Synaptosomes; Temperature | 1983 |
Inhibition of cold-induced TSH release by benzodiazepines.
Topics: Animals; Benzodiazepinones; Clonazepam; Cold Temperature; Depression, Chemical; Diazepam; Drug Interactions; Flumazenil; Male; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains; Thyrotropin; Thyrotropin-Releasing Hormone | 1983 |
Diazepam-induced release of behavior in an extinction procedure: its reversal by Ro 15-1788.
Topics: Amnesia; Animals; Behavior, Animal; Benzodiazepinones; Diazepam; Drinking; Extinction, Psychological; Flumazenil; Humans; Punishment; Rats | 1983 |
Convulsions induced by submaximal dose of pentylenetetrazol in mice are antagonized by the benzodiazepine antagonist Ro 15-1788.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Flumazenil; Male; Mice; Pentylenetetrazole; Seizures | 1983 |
Selective effects of diltiazem, a benzothiazepine calcium channel blocker, and diazepam, and other benzodiazepines on the Na+/Ca2+ exchange carrier system of heart and brain mitochondria.
Topics: Animals; Benzazepines; Benzodiazepines; Benzodiazepinones; Brain; Calcium; Carrier Proteins; Clonazepam; Diazepam; Diltiazem; Flumazenil; Mitochondria; Mitochondria, Heart; Rabbits; Rats; Sodium; Sodium-Calcium Exchanger | 1983 |
Reversal of the muscle relaxant effect of diazepam but not of progabide by a specific benzodiazepine antagonist: Ro 15-1788.
Topics: Animals; Benzodiazepinones; Diazepam; Female; Flumazenil; GABA Antagonists; gamma-Aminobutyric Acid; Male; Muscle Contraction; Muscle Relaxants, Central; Rats; Rats, Inbred Strains; Time Factors | 1983 |
Diazepam, pentobarbital, and methaqualone effects on several behaviors in the rat and antagonism by Ro 15-1788.
Topics: Animals; Behavior, Animal; Benzodiazepinones; Diazepam; Female; Flumazenil; Methaqualone; Pentobarbital; Postural Balance; Rats; Rats, Inbred Strains | 1983 |
A benzodiazepine antagonist is an anticonvulsant in an animal model for limbic epilepsy.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Diazepam; Drug Interactions; Flumazenil; Kindling, Neurologic; Male; Rats; Seizures | 1983 |
Anxiogenic aspects of diazepam withdrawal can be detected in animals.
Topics: Animals; Anxiety; Benzodiazepinones; Diazepam; Discrimination Learning; Flumazenil; Humans; Male; Pentobarbital; Pentylenetetrazole; Rats; Substance Withdrawal Syndrome | 1983 |
Diazepam antagonizes GABA- and muscimol-induced changes of acetylcholine release in slices of guinea-pig cerebral cortex.
Topics: Acetylcholine; Animals; Benzodiazepinones; Cerebral Cortex; Diazepam; Flumazenil; GABA Antagonists; Guinea Pigs; In Vitro Techniques; Muscimol; Oxazoles | 1983 |
Studies on [3H]diazepam and [3H]ethyl-beta-carboline carboxylate binding to rat brain in vivo. I. Regional variations in displacement.
Topics: Animals; Benzodiazepinones; Brain; Carbolines; Convulsants; Diazepam; Flumazenil; Flurazepam; Indoles; Male; Rats; Rats, Inbred Strains; Tissue Distribution | 1983 |
Inhibition of adenosine accumulation by a CNS benzodiazepine antagonist (Ro 15-1788) and a peripheral benzodiazepine receptor ligand (Ro 05-4864).
Topics: Adenosine; Animals; Benzodiazepines; Benzodiazepinones; Central Nervous System; Diazepam; Flumazenil; Flurazepam; Hexobendine; Male; Rats; Synaptosomes; Time Factors | 1983 |
Reversal of the muscle relaxant effect of diazepam by the specific benzodiazepine antagonist Ro 15-1788: an electromyographic study in morphine model of muscular rigidity in rats.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Diazepam; Drug Antagonism; Flumazenil; Male; Morphine; Muscle Contraction; Muscle Relaxation; Rats; Rats, Inbred Strains | 1983 |
Mechanism of potentiation by diazepam of adenosine response.
Topics: 2-Chloroadenosine; Adenosine; Animals; Benzodiazepinones; Cecum; Diazepam; Dipyridamole; Dose-Response Relationship, Drug; Drug Synergism; Female; Flumazenil; Hypoxanthine; Hypoxanthines; Inosine; Male; Rats; Rats, Inbred Strains | 1984 |
[Prolonged coma caused by diazepam sedation in ventilated patients. Diagnostic and therapeutic use of the benzodiazepine antagonist Ro 15-1788].
Topics: Aged; Benzodiazepinones; Coma; Convulsants; Diazepam; Electroencephalography; Female; Flumazenil; Humans; Male; Middle Aged; Respiration, Artificial | 1984 |
Intrinsic and antagonistic effects of beta-carboline FG 7142 on behavioral and EEG actions of benzodiazepines and pentobarbital in cats.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Carbolines; Cats; Diazepam; Drug Interactions; Electroencephalography; Flumazenil; Indoles; Male; Pentobarbital | 1983 |
Antagonism of caffeine-induced seizures in mice by Ro15-1788.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Caffeine; Diazepam; Female; Flumazenil; Mice; Receptors, Drug; Seizures | 1984 |
Diazepam blocks fear-enhanced startle elicited electrically from the brainstem.
Topics: Animals; Benzodiazepinones; Cochlea; Conditioning, Classical; Diazepam; Dose-Response Relationship, Drug; Electric Stimulation; Fear; Flumazenil; Male; Rats; Rats, Inbred Strains; Reflex, Startle | 1984 |
Evidence against the involvement of serotonergic neurons in the anti-punishment activity of diazepam in the rat.
Topics: 5,7-Dihydroxytryptamine; Animals; Benzodiazepinones; Conditioning, Operant; Diazepam; Dihydroxytryptamines; Electroshock; Flumazenil; Injections; Male; Neurons; Punishment; Raphe Nuclei; Rats; Rats, Inbred Strains; Reinforcement Schedule; Serotonin; Substantia Nigra | 1984 |
Precipitated diazepam withdrawal in baboons: effects of dose and duration of diazepam exposure.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Humans; Male; Papio; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1984 |
Effects of a benzodiazepine antagonist on the diazepam-induced electrical brain activity modifications.
Topics: Adult; Benzodiazepinones; Brain; Diazepam; Electroencephalography; Evoked Potentials, Auditory; Flumazenil; Humans | 1984 |
Anticonvulsant and antipunishment effects of toluene.
Topics: Animals; Benzodiazepinones; Conditioning, Operant; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Flumazenil; Male; Mice; Pentylenetetrazole; Punishment; Rats; Seizures; Time Factors; Toluene; Xylenes | 1984 |
Biphasic effects of Ro 15-1788 on spontaneous petit mal-like seizures in rats.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Convulsants; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Electroencephalography; Epilepsy, Absence; Flumazenil; Male; Rats; Rats, Inbred Strains | 1984 |
CGS 8216, Ro 15-1788 and methyl-beta-carboline-3-carboxylate, but not EMD 41717 antagonize the muscle relaxant effect of diazepam in genetically spastic rats.
Topics: Animals; Benzodiazepinones; Carbolines; Convulsants; Diazepam; Electromyography; Female; Flumazenil; Imidazoles; Kinetics; Male; Muscle Contraction; Muscle Relaxation; Muscle Spasticity; Pyrazoles; Rats; Rats, Mutant Strains | 1984 |
Bioassay of subjective effects associated with benzodiazepine withdrawal in animals: a novel direction in dependence research.
Topics: Animals; Benzodiazepinones; Biological Assay; Clonidine; Conditioning, Operant; Diazepam; Discrimination Learning; Flumazenil; Generalization, Stimulus; Humans; Male; Pentobarbital; Pentylenetetrazole; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 1984 |
The effects of RO15-1788, alone and in combination with diazepam, on ethanol-induced loss of righting reflex in rats.
Topics: Animals; Benzodiazepinones; Diazepam; Drug Synergism; Ethanol; Flumazenil; Motor Skills; Rats; Reflex | 1984 |
Characterization of convulsions induced by methyl beta-carboline-3-carboxylate in mice.
Topics: Animals; Benzodiazepinones; Carbolines; Convulsants; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Electroencephalography; Flumazenil; Hypnotics and Sedatives; Indoles; Male; Mice; Pentylenetetrazole; Postural Balance; Time Factors | 1984 |
Use of the specific benzodiazepine antagonist, Ro 15-1788, in studies of physiological dependence on benzodiazepines.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Cats; Diazepam; Female; Flumazenil; Humans; Lorazepam; Male; Mice; Rats; Saimiri; Substance Withdrawal Syndrome; Substance-Related Disorders; Triazolam | 1982 |
Effects of benzodiazepines on single unit activity in the substantia nigra pars reticulata.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Bicuculline; Caffeine; Diazepam; Dose-Response Relationship, Drug; Electric Conductivity; Flumazenil; Flurazepam; Male; Neurons; Picrotoxin; Rats; Rats, Inbred Strains; Substantia Nigra; Theophylline | 1982 |
The effect of a benzodiazepine antagonist, RO15-1788, in diazepam dependent rats.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Diazepam; Dose-Response Relationship, Drug; Female; Flumazenil; Humans; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Substance-Related Disorders | 1982 |
Modification of the anticonvulsant efficacy of diazepam by Ro-15-1788 in the kindled amygdaloid seizure model.
Topics: Amygdala; Animals; Anticonvulsants; Benzodiazepinones; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Flumazenil; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains; Seizures | 1982 |
Blockade of 3-carbomethoxy-beta-carboline induced seizures by diazepam and the benzodiazepine antagonists, Ro 15-1788 and CGS 8216.
Topics: Animals; Benzodiazepinones; Carbolines; Convulsants; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Harmaline; Indoles; Male; Mice; Pyrazoles; Seizures; Tremor | 1982 |
Ro 15-1788 antagonizes the discriminative stimulus effects of diazepam in rats but not similar effects of pentobarbital.
Topics: Animals; Benzodiazepinones; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Flumazenil; Kinetics; Male; Pentobarbital; Rats; Rats, Inbred F344 | 1982 |
Methyl-beta-carboline-induced convulsions are antagonized by Ro 15-1788 and by propyl-beta-carboline.
Topics: Animals; Benzodiazepinones; Carbolines; Diazepam; Flumazenil; Indoles; Papio; Photosensitivity Disorders; Seizures; Time Factors | 1982 |
Reversal of the anticonvulsant effects of diazepam on amygdaloid-kindled seizures by a specific benzodiazepine antagonist: RO 15-1788.
Topics: Amygdala; Animals; Anticonvulsants; Benzodiazepinones; Diazepam; Electroencephalography; Flumazenil; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains | 1982 |
Benzodiazepines influence melatonin secretion of the pineal organ of the trout in vitro.
Topics: 5-Methoxytryptamine; Animals; Benzodiazepines; Calcium; Clonazepam; Culture Media; Dark Adaptation; Diazepam; Flumazenil; Hydroxyindoleacetic Acid; In Vitro Techniques; Indoles; Isoquinolines; Light; Magnesium; Melatonin; Oncorhynchus mykiss; Pineal Gland | 1994 |
Effect of diazepam on cortical 5-HT release and behaviour in the guinea-pig on exposure to the elevated plus maze.
Topics: Animals; Anxiety; Behavior, Animal; Diazepam; Exploratory Behavior; Extracellular Space; Female; Flumazenil; Guinea Pigs; Hydroxyindoleacetic Acid; Microdialysis; Prefrontal Cortex; Serotonin | 1993 |
Role of GABAergic systems in the development of morphine tolerance in formalin-treated mice.
Topics: Analgesics, Opioid; Animals; Baclofen; Bicuculline; Diazepam; Drug Tolerance; Flumazenil; Formaldehyde; GABA Agonists; GABA Antagonists; Male; Mice; Mice, Inbred Strains; Morphine; Muscimol; Pain; Pain Measurement; Receptors, GABA | 1995 |
Involvement of benzodiazepine/GABA-A receptor complex in ethanol-induced state-dependent learning in rats.
Topics: Animals; Avoidance Learning; Azides; Benzodiazepines; Bicuculline; Diazepam; Ethanol; Evaluation Studies as Topic; Flumazenil; Male; Muscimol; Picrotoxin; Rats; Rats, Wistar; Reaction Time; Receptors, GABA-A | 1995 |
Flunitrazepam and nordiazepam slowly released from silastic capsules induce physical dependence in rat.
Topics: Animals; Anti-Anxiety Agents; Antidotes; Biological Availability; Delayed-Action Preparations; Diazepam; Drug Implants; Female; Flumazenil; Flunitrazepam; Nordazepam; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Substance-Related Disorders | 1995 |
Stereospecific transduction of behavioral effects via diazepam-insensitive GABAA receptors.
Topics: Animals; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Binding Sites; Binding, Competitive; Columbidae; Diazepam; Discrimination Learning; Flumazenil; GABA Modulators; Imidazoles; Male; Midazolam; Oxadiazoles; Radioligand Assay; Receptors, GABA-A; Sensitivity and Specificity; Stereoisomerism | 1995 |
Precipitated withdrawal in squirrel monkeys after repeated daily oral administration of alprazolam, diazepam, flunitrazepam or oxazepam.
Topics: Administration, Oral; Alprazolam; Animals; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Drug Tolerance; Female; Flumazenil; Flunitrazepam; Male; Muscle Relaxation; Oxazepam; Saimiri; Sleep; Substance Withdrawal Syndrome; Substance-Related Disorders; Tremor | 1995 |
Effects of intravenous anesthetics on phosphatidylinositol turnover in rat cerebral cortical prisms.
Topics: Anesthetics, Intravenous; Animals; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Droperidol; Fentanyl; Flumazenil; Inositol Phosphates; Ketamine; Male; Naloxone; Norepinephrine; Phosphatidylinositols; Prazosin; Rats; Rats, Wistar; Thiamylal | 1994 |
Oral flumazenil in the treatment of epilepsy.
Topics: Administration, Oral; Clinical Trials as Topic; Diazepam; Drug Therapy, Combination; Epilepsy; Epilepsy, Generalized; Flumazenil; Humans; Randomized Controlled Trials as Topic; Single-Blind Method | 1995 |
Benzodiazepine agonists reverse the effects of noise exposure on central benzodiazepine receptors and cardiac responsiveness.
Topics: Animals; Brain; Clonazepam; Diazepam; Flumazenil; Imidazoles; Male; Myocardium; Noise; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, GABA-A; Stress, Psychological | 1995 |
Gastrointestinal effects of diazepam-withdrawal are linked to activation of central cholecystokinin-ergic pathways in rats.
Topics: Animals; Benzodiazepinones; Brain; Cholecystokinin; Devazepide; Diazepam; Flumazenil; Gastrointestinal Motility; Gastrointestinal Transit; Male; Phenylurea Compounds; Rats; Rats, Wistar; Receptors, Cholecystokinin; Substance Withdrawal Syndrome | 1994 |
The effects of drugs acting at GABA-benzodiazepine-barbiturate receptor complex on the behaviour of sleep-deprived mice.
Topics: Analysis of Variance; Animals; Azides; Behavior, Animal; Benzodiazepines; Convulsants; Diazepam; Flumazenil; Male; Mice; Receptors, GABA-A; Sleep Deprivation | 1995 |
Paradoxical reactions to diazepam.
Topics: Conscious Sedation; Diazepam; Flumazenil; Humans; Psychomotor Agitation | 1995 |
Different location of benzodiazepine sites involved in gut and behavioral effects of benzodiazepine withdrawal in rats.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Capsaicin; Diazepam; Digestive System; Flumazenil; Gastric Emptying; Injections, Intraventricular; Male; Rats; Rats, Wistar; Receptors, GABA-A; Substance Withdrawal Syndrome | 1994 |
Diazepam attenuates hyperexcitability and mechanical hypersensitivity of dorsal horn convergent neurones during reperfusion of the rat's tail following ischaemia.
Topics: Animals; Diazepam; Electrophysiology; Flumazenil; Ischemia; Male; Naloxone; Neurons; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reperfusion; Spinal Cord; Tail | 1994 |
Discriminative stimulus properties of a new anxiolytic, DN-2327, in rats.
Topics: Animals; Anti-Anxiety Agents; Buspirone; Cues; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Flumazenil; Generalization, Stimulus; Isoindoles; Male; Naphthyridines; Pentobarbital; Pentylenetetrazole; Rats; Rats, Wistar; Spiro Compounds | 1993 |
Benzodiazepine receptor mediation of the anxiolytic-like effect of (-)-nicotine in mice.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Diazepam; Flumazenil; Male; Mecamylamine; Mice; Nicotine; Receptors, GABA-A; Receptors, Nicotinic | 1994 |
Corticosterone increases severity of acute withdrawal from ethanol, pentobarbital, and diazepam in mice.
Topics: Animals; Behavior, Animal; Corticosterone; Diazepam; Ethanol; Female; Flumazenil; Handling, Psychological; Mice; Mice, Inbred Strains; Pentobarbital; Seizures; Substance Withdrawal Syndrome | 1994 |
Role of benzodiazepine receptors located in the dorsal periaqueductal grey of rats in anxiety.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Anxiety; Appetite Depressants; Carbolines; Diazepam; Dose-Response Relationship, Drug; Exploratory Behavior; Flumazenil; Male; Microinjections; Midazolam; Periaqueductal Gray; Rats; Rats, Wistar; Receptors, GABA-A | 1993 |
Diazepam and gepirone selectively attenuate either 20-32 or 32-64 kHz ultrasonic vocalizations during aggressive encounters.
Topics: Aggression; Animals; Anti-Anxiety Agents; Depression, Chemical; Diazepam; Dose-Response Relationship, Drug; Exploratory Behavior; Flumazenil; Male; Motor Activity; Pain Measurement; Pyrimidines; Rats; Vocalization, Animal | 1993 |
Differential profile of the CCKB receptor antagonist CI-988 and diazepam in the four-plate test.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Dose-Response Relationship, Drug; Electroshock; Exploratory Behavior; Flumazenil; Indoles; Male; Meglumine; Mice; Ondansetron; Receptors, Cholecystokinin | 1993 |
Effects of the non-NMDA antagonists NBQX and the 2,3-benzodiazepine GYKI 52466 on different seizure types in mice: comparison with diazepam and interactions with flumazenil.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Excitatory Amino Acid Antagonists; Flumazenil; Male; Mice; Muscle Relaxants, Central; Pentylenetetrazole; Quinoxalines; Receptors, AMPA; Reflex; Seizures; Synaptic Transmission | 1994 |
Different functional effect of Ro 15-4513 and Ro 19-4603 on synaptic responses of Purkinje cells in the rat cerebellar slice.
Topics: Animals; Azepines; Azides; Benzodiazepines; Cerebellum; Diazepam; Electrophysiology; Flumazenil; In Vitro Techniques; Male; Neural Inhibition; Purkinje Cells; Rats; Rats, Wistar; Receptors, GABA-A; Synapses | 1994 |
Gender differences in diazepam withdrawal syndrome in mice.
Topics: Animals; Body Weight; Castration; Diazepam; Disease Models, Animal; Estrogens; Female; Flumazenil; Injections, Intraperitoneal; Male; Mice; Seizures; Sex Characteristics; Substance Withdrawal Syndrome; Testosterone | 1994 |
Repeated treatment with alpidem, a new anxiolytic, does not induce tolerance or physical dependence.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Bicuculline; Carbolines; Convulsants; Diazepam; Drug Tolerance; Flumazenil; Imidazoles; Isoniazid; Male; Mice; Pentylenetetrazole; Pyridines; Seizures; Substance Withdrawal Syndrome; Substance-Related Disorders | 1993 |
A system for testing the development and reversal of anticonvulsant tolerance to benzodiazepines in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Carbolines; Diazepam; Drug Tolerance; Flumazenil; Flunitrazepam; Infusion Pumps, Implantable; Infusions, Parenteral; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Seizures; Solvents; Time Factors | 1993 |
Anxiolytic activity of melatonin in mice: involvement of benzodiazepine receptors.
Topics: Animals; Anti-Anxiety Agents; Choice Behavior; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Male; Melatonin; Mice; Motor Activity; Receptors, GABA-A | 1993 |
Duodenal bicarbonate secretion and mucosal protection. Neurohumoral influence and transport mechanisms.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antiporters; Bicarbonates; Biological Transport; Carbachol; Carrier Proteins; Catechol O-Methyltransferase Inhibitors; Catechols; Chloride-Bicarbonate Antiporters; Cyclic AMP; Cytophotometry; Diazepam; Dopamine; Dopamine Agents; Duodenum; Ergolines; Flumazenil; Gastric Mucosa; Intestinal Mucosa; Male; Microvilli; Pentanones; Phentolamine; Pirenzepine; Quinpirole; Radioimmunoassay; Rana catesbeiana; Rats; Rats, Sprague-Dawley; Sodium-Bicarbonate Symporters; Sodium-Hydrogen Exchangers; Ulcer | 1993 |
Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passiflora coerulea.
Topics: Animals; Anti-Anxiety Agents; Diazepam; Exploratory Behavior; Flavonoids; Flumazenil; Male; Mice; Mice, Inbred Strains; Motor Activity; Plants, Medicinal; Receptors, GABA-A | 1994 |
Dehydroepiandrosterone is an anxiolytic in mice on the plus maze.
Topics: Animals; Anti-Anxiety Agents; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Diazepam; Ethanol; Flumazenil; Male; Mice; Mice, Inbred C57BL; Motor Activity; Pentylenetetrazole; Receptors, GABA | 1994 |
F 2692: flumazenil-reversible anxiolytic effects but inactive on [3H]-Ro 15-4513 binding.
Topics: Affinity Labels; Animals; Anti-Anxiety Agents; Azides; Benzodiazepines; Binding, Competitive; Carbolines; Cerebellum; Diazepam; Flumazenil; GABA-A Receptor Antagonists; In Vitro Techniques; Interpersonal Relations; Male; Membranes; Motor Activity; Pyridazines; Rats; Receptors, GABA-A | 1994 |
Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice.
Topics: Animals; Anxiety; Aspirin; Diazepam; Drug Tolerance; Flumazenil; Formaldehyde; Indomethacin; Inflammation; Male; Mice; Morphine; Pain; Pain Threshold; Receptors, GABA-A | 1994 |
Differential effects of abecarnil on basal release of acetylcholine and dopamine in the rat brain.
Topics: Acetylcholine; Animals; Anti-Anxiety Agents; Brain; Carbolines; Diazepam; Dopamine; Flumazenil; GABA-A Receptor Agonists; Hippocampus; Male; Microdialysis; Neurons; Prefrontal Cortex; Rats; Rats, Sprague-Dawley | 1994 |
Ejaculation induced changes in escape latency in the hot plate test: pharmacological analysis of anxiolytic versus analgesic effect.
Topics: Animals; Arousal; Copulation; Diazepam; Ejaculation; Escape Reaction; Female; Flumazenil; Habituation, Psychophysiologic; Male; Morphine; Naloxone; Pain Threshold; Rats; Rats, Wistar; Reaction Time; Thermosensing; Vocalization, Animal | 1994 |
The benzodiazepine receptor antagonist flumazenil increases acetylcholine release in rat hippocampus.
Topics: Acetylcholine; Animals; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GABA-A Receptor Antagonists; Hippocampus; Injections; Injections, Intraperitoneal; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Septum Pellucidum | 1994 |
Seizure after reversal of benzodiazepine treatment with flumazenil: a report of two cases.
Topics: Aged; Diazepam; Female; Flumazenil; Humans; Male; Middle Aged; Receptors, GABA; Seizures | 1994 |
Melatonin as an anxiolytic in rats: time dependence and interaction with the central GABAergic system.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Behavior, Animal; Brain; Circadian Rhythm; Diazepam; Dose-Response Relationship, Drug; Drug Administration Schedule; Flumazenil; gamma-Aminobutyric Acid; Male; Melatonin; Rats; Rats, Wistar | 1993 |
Flumazenil as a diagnostic tool in the differential diagnosis of coma in a critically ill patient.
Topics: Aged; Bacterial Infections; Coma; Critical Illness; Diagnosis, Differential; Diazepam; Flumazenil; Hepatic Encephalopathy; Humans; Lorazepam; Male; Midazolam | 1994 |
Flumazenil induces localised increases in glucose utilization during diazepam withdrawal in rats.
Topics: Animals; Autoradiography; Brain Chemistry; Carbolines; Densitometry; Deoxyglucose; Diazepam; Flumazenil; Glucose; Male; Rats; Substance Withdrawal Syndrome | 1993 |
Flumazenil induces seizures and death in mixed cocaine-diazepam intoxications.
Topics: Animals; Cocaine; Diazepam; Electroencephalography; Flumazenil; Male; Rats; Rats, Sprague-Dawley; Seizures | 1994 |
[A pregnant woman with convulsion treated with diazepam which was reversed with flumazenil just prior to cesarean section].
Topics: Adult; Anesthesia, General; Anesthesia, Obstetrical; Cesarean Section; Diazepam; Eclampsia; Emergencies; Female; Flumazenil; Humans; Injections, Intravenous; Pregnancy | 1994 |
[The effect of flumazenil administration on acute cocaine intoxication of rats].
Topics: Acute Disease; Animals; Cocaine; Diazepam; Flumazenil; Male; Poisoning; Rats; Rats, Wistar | 1994 |
Propofol activates GABAA receptor-chloride ionophore complex in dissociated hippocampal pyramidal neurons of the rat.
Topics: Animals; Central Nervous System; Chloride Channels; Chlorides; Diazepam; Flumazenil; Hippocampus; Kinetics; Membrane Potentials; Neurons; Propofol; Pyramidal Tracts; Rats; Rats, Wistar; Receptors, GABA | 1993 |
Pentobarbital, diazepam, and ethanol abolish the interphase diminution of pain in the formalin test: evidence for pain modulation by GABAA receptors.
Topics: Analgesics; Animals; Chloride Channels; Diazepam; Ethanol; Flumazenil; Formaldehyde; Male; Pain Measurement; Pentobarbital; Picrotoxin; Rats; Receptors, GABA-A | 1993 |
Precipitated abstinence in the diazepam-dependent rat.
Topics: Animals; Behavior, Animal; Brain; Diazepam; Drug Implants; Epilepsy, Tonic-Clonic; Female; Flumazenil; Microdialysis; Particle Size; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Substance-Related Disorders | 1993 |
Effects of benzodiazepine agonist, antagonist and inverse agonist on ethanol-induced changes in beta-endorphin levels in specific rat brain regions.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; beta-Endorphin; Brain Chemistry; Cerebral Cortex; Diazepam; Ethanol; Flumazenil; Hippocampus; Hypothalamus; Male; Rats; Rats, Sprague-Dawley | 1993 |
Attenuation of reperfusion hyperalgesia in the rat by systemic administration of benzodiazepines.
Topics: Animals; Behavior, Animal; Benzodiazepines; Chlordiazepoxide; Depression, Chemical; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Hyperalgesia; Ischemia; Male; Motor Activity; Naloxone; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Reperfusion Injury; Tail | 1993 |
In vitro inhibition of cellular immune responses by benzodiazepines and PK 11195. Effects on mitogen- and alloantigen-driven lymphocyte proliferation and on IL-1, IL-2 synthesis and IL-2 receptor expression.
Topics: Animals; B-Lymphocytes; Benzodiazepines; Benzodiazepinones; Clonazepam; Diazepam; Female; Flumazenil; Immunity, Cellular; In Vitro Techniques; Interleukin-1; Interleukin-2; Isoquinolines; Lymphocyte Activation; Male; Mice; Mice, Inbred A; Mice, Inbred C57BL; Neuroimmunomodulation; Receptors, GABA-A; T-Lymphocytes | 1993 |
Flumazenil reverses diazepam-induced neonatal apnoea and hypotonia.
Topics: Apnea; Diazepam; Flumazenil; Humans; Infant, Newborn; Male; Muscle Hypotonia | 1993 |
Functional integrity of benzodiazepine receptors of the geniculo-striate visual pathways in Creutzfeldt-Jakob disease. A pharmacological evoked potential study.
Topics: Creutzfeldt-Jakob Syndrome; Diazepam; Evoked Potentials, Visual; Flumazenil; Humans; Male; Middle Aged; Reaction Time; Receptors, GABA-A; Visual Cortex | 1993 |
Interaction between benzodiazepine and GABA-A receptors in state-dependent learning.
Topics: Animals; Avoidance Learning; Baclofen; Bicuculline; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Male; Muscimol; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA-A; Reference Values | 1993 |
Imidazenil: a new partial positive allosteric modulator of gamma-aminobutyric acid (GABA) action at GABAA receptors.
Topics: Allosteric Regulation; Animals; Benzodiazepines; Benzodiazepinones; Chloride Channels; Conflict, Psychological; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Imidazoles; Male; Membrane Proteins; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reflex; Seizures | 1993 |
Transduction of a discriminative stimulus through a diazepam-insensitive gamma-aminobutyric acidA receptor.
Topics: Animals; Columbidae; Diazepam; Discrimination Learning; Flumazenil; gamma-Aminobutyric Acid; Male; Receptors, GABA-A | 1993 |
Inhibitory effect of diazepam on the activity of the hypothalamic-pituitary-adrenal axis in female rats.
Topics: Adrenocorticotropic Hormone; Animals; Bicuculline; Corticosterone; Depression, Chemical; Diazepam; Female; Flumazenil; GABA-A Receptor Antagonists; Hypothalamo-Hypophyseal System; Isoquinolines; Picrotoxin; Pituitary-Adrenal System; Rats; Receptors, GABA-A | 1993 |
Potentiation of gamma-aminobutyric acid type A receptor-mediated synaptic currents by pentobarbital and diazepam in immature hippocampal CA1 neurons.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Diazepam; Drug Synergism; Flumazenil; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; Neurons; Pentobarbital; Rats; Rats, Wistar; Receptors, GABA-A; Synapses | 1993 |
Inhibition of hippocampal acetylcholine release by benzodiazepines: antagonism by flumazenil.
Topics: Acetylcholine; Analysis of Variance; Animals; Diazepam; Drug Interactions; Flumazenil; Hippocampus; Male; Midazolam; Rats; Rats, Sprague-Dawley | 1993 |
Pharmacokinetics of nordiazepam in physical dependence and precipitated abstinence in dogs.
Topics: Administration, Oral; Animals; Blood Proteins; Diazepam; Dogs; Female; Flumazenil; Hydrolysis; Injections, Intravenous; Nordazepam; Oxazepam; Protein Binding; Substance Withdrawal Syndrome; Substance-Related Disorders | 1993 |
Reversal of fetal benzodiazepine intoxication using flumazenil.
Topics: Adult; Cardiotocography; Diazepam; Drug Overdose; Female; Fetal Diseases; Flumazenil; Gastric Lavage; Humans; Pregnancy | 1993 |
Effect of the chronic dose of diazepam on the intensity and characteristics of the precipitated abstinence syndrome in the dog.
Topics: Animals; Diazepam; Dogs; Dose-Response Relationship, Drug; Female; Flumazenil; Substance Withdrawal Syndrome | 1993 |
The relative efficacy of antidotes.
Topics: Antidotes; Atropine; Chelating Agents; Diazepam; Flumazenil; Humans; Naloxone; Poisoning | 1995 |
Enhancement of acetylcholine release by flumazenil in the hippocampus of rats chronically treated with diazepam but not with imidazenil or abecarnil.
Topics: Acetylcholine; Animals; Anticonvulsants; Benzodiazepines; Carbolines; Diazepam; Flumazenil; GABA Modulators; Hippocampus; Imidazoles; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Time Factors | 1995 |
Blockade of morphine-induced place preference by diazepam in mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Conditioning, Psychological; Diazepam; Dopamine; Drug Interactions; Flumazenil; GABA Modulators; Homovanillic Acid; Injections, Intraperitoneal; Male; Mice; Morphine; Narcotic Antagonists | 1995 |
[The effect of diazepam and flumazenil on pulsatile secretion of prolactin and LH in women].
Topics: Adult; Diazepam; Female; Flumazenil; GABA Modulators; Humans; Luteinizing Hormone; Menstrual Cycle; Prolactin | 1996 |
Long-term intravenous and oral flumazenil treatment of acute diazepam overdose in an older patient.
Topics: Administration, Oral; Aged; Antidotes; Coma; Diazepam; Female; Flumazenil; Glasgow Coma Scale; Humans; Infusions, Intravenous | 1996 |
Lack of anticonvulsant tolerance and benzodiazepine receptor down regulation with imidazenil in rats.
Topics: Animals; Anticonvulsants; Benzodiazepines; Bicuculline; Diazepam; Down-Regulation; Drug Tolerance; Flumazenil; GABA Modulators; Imidazoles; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Tritium | 1996 |
Diazepam increases melatonin secretion of photosensitive pineal organs of trout in the photopic and mesopic range of illumination.
Topics: Animals; Diazepam; Flumazenil; GABA Modulators; In Vitro Techniques; Light; Melatonin; Pineal Gland; Trout | 1996 |
Effects of several benzodiazepines, alone and in combination with flumazenil, in rhesus monkeys trained to discriminate pentobarbital from saline.
Topics: Animals; Anti-Anxiety Agents; Chlordiazepoxide; Conditioning, Operant; Diazepam; Discrimination Learning; Drug Interactions; Flumazenil; GABA-A Receptor Antagonists; Macaca mulatta | 1995 |
Vigabatrin modulates benzodiazepine receptor activity in vivo: a positron emission tomography study in baboon.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flumazenil; gamma-Aminobutyric Acid; Linear Models; Male; Papio; Radioligand Assay; Receptors, GABA-A; Tomography, Emission-Computed; Vigabatrin | 1996 |
Reciprocal effects of chronic diazepam and melatonin on brain melatonin and benzodiazepine binding sites.
Topics: Animals; Body Weight; Brain; Cerebral Cortex; Diazepam; Flumazenil; Flunitrazepam; Kinetics; Male; Medulla Oblongata; Melatonin; Pons; Rats; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, GABA-A; Receptors, Melatonin | 1996 |
Effects of diazepam, baclofen and thiopental on the silent period evoked by transcranial magnetic stimulation in humans.
Topics: Adult; Baclofen; Diazepam; Electric Stimulation; Evoked Potentials; Flumazenil; GABA Agonists; GABA Modulators; Humans; Middle Aged; Motor Cortex; Neural Inhibition; Thiopental; Transcranial Magnetic Stimulation | 1996 |
Anticonvulsant profile of the imidazoquinazolines NNC 14-0185 and NNC 14-0189 in rats and mice.
Topics: Acoustic Stimulation; Amygdala; Animals; Anticonvulsants; Bicuculline; Carbolines; Clonazepam; Diazepam; Electroshock; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; Kindling, Neurologic; Male; Mice; Mice, Inbred DBA; Mice, Inbred Strains; Pentylenetetrazole; Quinazolines; Rats; Rats, Wistar; Seizures | 1996 |
Effects of benzodiazepine receptor ligands on isolated rat superior cervical ganglia neurons.
Topics: Age Factors; Animals; Animals, Newborn; Anti-Anxiety Agents; Diazepam; Electrophysiology; Flumazenil; gamma-Aminobutyric Acid; Ligands; Neurons; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Superior Cervical Ganglion | 1996 |
Functional preservation of benzodiazepine receptors of the primary somatosensory cortex in Creutzfeldt-Jakob disease: a pharmacologic-evoked potential study.
Topics: Aged; Creutzfeldt-Jakob Syndrome; Diazepam; Electroencephalography; Evoked Potentials, Somatosensory; Fatal Outcome; Female; Flumazenil; GABA Modulators; Humans; Median Nerve; Receptors, GABA-A; Somatosensory Cortex | 1996 |
Flumazenil, diazepam, nordiazepam and oxazepam interactions on plasma protein binding.
Topics: Animals; Anti-Anxiety Agents; Biotransformation; Blood Proteins; Diazepam; Dogs; Drug Interactions; Flumazenil; In Vitro Techniques; Nordazepam; Oxazepam; Protein Binding | 1995 |
PK 11195 blockade of benzodiazepine-induced inhibition of forskolin-stimulated adenylate cyclase activity in the striatum.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Benzodiazepines; Benzodiazepinones; Colforsin; Corpus Striatum; Diazepam; Drug Interactions; Flumazenil; GABA-A Receptor Antagonists; Guanosine Triphosphate; Indoles; Isoquinolines; Kinetics; Male; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Virulence Factors, Bordetella | 1996 |
The possible involvement of GABAA systems in the antinarcotic effect of majonoside-R2, a major constituent of Vietnamese ginseng, in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Analysis of Variance; Animals; Convulsants; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; Ginsenosides; Male; Mice; Morphine; Pain Measurement; Picrotoxin; Pyrrolidines; Saponins | 1996 |
Effect of inhalation of chamomile oil vapour on plasma ACTH level in ovariectomized-rat under restriction stress.
Topics: Administration, Inhalation; Adrenocorticotropic Hormone; Animals; Anti-Anxiety Agents; Diazepam; Female; Flumazenil; GABA Modulators; Hypnotics and Sedatives; Ovariectomy; Plant Oils; Plants, Medicinal; Rats; Rats, Wistar; Restraint, Physical; Stress, Psychological | 1996 |
Diazepam physical dependence and withdrawal in rats is associated with alteration in GABAA receptor function.
Topics: Animals; Benzodiazepines; Cerebral Cortex; Chloride Channels; Chlorides; Diazepam; Flumazenil; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred F344; Receptors, GABA-A; Substance Withdrawal Syndrome; Substance-Related Disorders | 1996 |
Pharmacology of the human gamma-aminobutyric acidA receptor alpha 4 subunit expressed in Xenopus laevis oocytes.
Topics: Animals; Benzodiazepines; Binding Sites; Diazepam; Electrophysiology; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; Humans; Macromolecular Substances; Pentobarbital; Receptors, GABA-A; Sensitivity and Specificity; Xenopus laevis | 1996 |
Intraseptal flumazenil enhances, while diazepam binding inhibitor impairs, performance in a working memory task.
Topics: Animals; Diazepam; Flumazenil; Male; Maze Learning; Memory; Rats; Rats, Sprague-Dawley; Septal Nuclei; Task Performance and Analysis | 1996 |
Characterisation of the furanocoumarin phellopterin as a rat brain benzodiazepine receptor partial agonist in vitro.
Topics: Animals; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Coumarins; Diazepam; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; In Vitro Techniques; Male; Rats; Rats, Wistar; Receptors, GABA; Receptors, GABA-A | 1996 |
Role of GABA-A and mitochondrial diazepam binding inhibitor receptors in the anti-stress activity of neurosteroids in mice.
Topics: Analysis of Variance; Animals; Ascorbic Acid; Behavior, Animal; Binding Sites; Cerebellum; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GABA Antagonists; GABA Modulators; Isoquinolines; Male; Mice; Mitochondria; Motor Activity; Pain Measurement; Picrotoxin; Progesterone; Receptors, GABA-A; RNA; Stress, Psychological; Triazolam | 1996 |
Progesterone modulation of diazepam withdrawal syndrome in mice.
Topics: Animals; Anti-Anxiety Agents; Diazepam; Estradiol; Estrus; Female; Flumazenil; GABA Modulators; Mice; Progesterone; Substance Withdrawal Syndrome | 1996 |
Intrathecally administered flumazenil and PK 11195 precipitate abstinence syndrome in freely moving diazepam dependent rats.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Electrodes, Implanted; Electroencephalography; Female; Flumazenil; GABA-A Receptor Antagonists; Injections, Spinal; Isoquinolines; Rats; Rats, Sprague-Dawley; Tremor | 1996 |
Flumazenil reverses the decrease in the hypnotic activity of pentobarbital by social isolation stress: are endogenous benzodiazepine receptor ligands involved?
Topics: Animals; Carbolines; Chlorides; Diazepam; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; Hypnotics and Sedatives; In Vitro Techniques; Ligands; Male; Mice; Mice, Inbred Strains; Pentobarbital; Receptors, GABA-A; Sleep; Social Isolation; Stress, Psychological; Synaptosomes | 1997 |
In vivo modulation of benzodiazepine receptor function after inhibition of endogenous gamma-aminobutyyric acid synthesis.
Topics: Allylglycine; Animals; Binding, Competitive; Brain; Convulsants; Diazepam; Electroencephalography; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Ligands; Male; Papio; Pentylenetetrazole; Tomography, Emission-Computed | 1997 |
Stimulatory effect of diazepam on gastric acid secretion in the continuously perfused stomach in rats under urethane anesthesia.
Topics: 3-Mercaptopropionic Acid; Analysis of Variance; Anesthetics, Intravenous; Animals; Atropine; Diazepam; Flumazenil; GABA Agents; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; Gastric Acid; Gastric Mucosa; Hexamethonium; Isoquinolines; Male; Parasympatholytics; Pentylenetetrazole; Picrotoxin; Pylorus; Rats; Rats, Wistar; Receptors, GABA; Urethane; Vagotomy | 1997 |
Benzodiazepine receptor distribution and diazepam binding in schizophrenia: an exploratory study.
Topics: Adult; Benzodiazepines; Binding Sites; Chronic Disease; Diazepam; Flumazenil; Frontal Lobe; Growth Hormone; Humans; Hydrocortisone; Occipital Lobe; Receptors, GABA-A; Schizophrenia; Temporal Lobe; Tomography, Emission-Computed, Single-Photon | 1997 |
Sex differences in bicuculline-induced convulsions: interaction with stress and ligands of benzodiazepine binding sites.
Topics: Animals; Benzodiazepines; Bicuculline; Binding Sites; Cold Temperature; Diazepam; Differential Threshold; Dose-Response Relationship, Drug; Female; Flumazenil; Handling, Psychological; Ligands; Male; Rats; Rats, Wistar; Seizures; Sex Characteristics; Stress, Physiological; Swimming | 1997 |
Subtle changes in residue 77 of the gamma subunit of alpha1beta2gamma2 GABAA receptors drastically alter the affinity for ligands of the benzodiazepine binding site.
Topics: Animals; Benzodiazepines; Binding Sites; Cell Line; Diazepam; Female; Flumazenil; Humans; Kinetics; Macromolecular Substances; Mutagenesis, Site-Directed; Oocytes; Phenylalanine; Point Mutation; Pyridines; Radioligand Assay; Rats; Receptors, GABA-A; Recombinant Proteins; Transfection; Xenopus laevis; Zolpidem | 1997 |
Antianxiety profile of ondansetron, a selective 5-HT3 antagonist, in a novel animal model.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Conflict, Psychological; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Female; Flumazenil; GABA Modulators; Male; Mice; Mice, Inbred BALB C; Ondansetron; Serotonin Antagonists | 1997 |
Enhancement by flumazenil of dopamine release in the nucleus accumbens of rats repeatedly exposed to diazepam or imidazenil.
Topics: Animals; Benzodiazepines; Diazepam; Dopamine; Drug Synergism; Flumazenil; GABA Modulators; Imidazoles; Male; Nucleus Accumbens; Rats; Rats, Sprague-Dawley | 1997 |
Hippocampal GABA(A) channel conductance increased by diazepam.
Topics: Animals; Cells, Cultured; Diazepam; Dose-Response Relationship, Drug; Electric Conductivity; Flumazenil; GABA Modulators; Hippocampus; Neurons; Rats; Receptors, GABA-A | 1997 |
GABA(A) receptors containing the alpha4-subunit: prevalence, distribution, pharmacology, and subunit architecture in situ.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Brain; Cell Membrane; Cerebellum; Diazepam; Flumazenil; Immunohistochemistry; Immunosorbent Techniques; Macromolecular Substances; Male; Muscimol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Recombinant Proteins | 1997 |
Benzodiazepine prevention of swim stress-induced sensitization of cortical biogenic amines: an in vivo microdialysis study.
Topics: Animals; Anti-Anxiety Agents; Biogenic Amines; Carbolines; Diazepam; Drug Evaluation, Preclinical; Flumazenil; GABA Agonists; GABA Antagonists; Male; Microdialysis; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Stress, Physiological; Swimming | 1997 |
Non-GABAergic effects of midazolam, diazepam and flumazenil on voltage-dependent ion currents in NG108-15 cells.
Topics: Animals; Calcium Channels; Diazepam; Dose-Response Relationship, Drug; Flumazenil; gamma-Aminobutyric Acid; Glioma; Hybrid Cells; Ion Channels; Membrane Potentials; Midazolam; Neuroblastoma; Patch-Clamp Techniques; Potassium Channels; Receptors, GABA-A; Sodium Channels | 1997 |
Dorsal raphe and substantia nigra response to flumazenil in diazepam-dependent rats.
Topics: Animals; Diazepam; Electroencephalography; Electrophysiology; Female; Flumazenil; GABA Modulators; Microinjections; Prefrontal Cortex; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Substance-Related Disorders; Substantia Nigra | 1997 |
Mechanism of the negative inotropic effect of midazolam and diazepam in cultured foetal mouse cardiac myocytes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Anti-Anxiety Agents; Calcium; Calcium Channel Agonists; Cells, Cultured; Depression, Chemical; Diazepam; Female; Fetal Heart; Flumazenil; GABA-A Receptor Antagonists; Heart Rate, Fetal; Hypnotics and Sedatives; Mice; Mice, Inbred ICR; Midazolam; Pregnancy; Ryanodine; Sarcoplasmic Reticulum | 1997 |
A fatality due to moclobemide.
Topics: Antidepressive Agents; Benzamides; Diazepam; Fatal Outcome; Female; Flumazenil; Humans; Liver; Middle Aged; Moclobemide; Nordazepam; Trifluoperazine | 1997 |
Influence of anxiolytic drugs on the effects of specific serotonin reuptake inhibitors in the forced swimming test in mice.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Diazepam; Drug Interactions; Flumazenil; Fluoxetine; GABA Modulators; Male; Mice; Motor Activity; Selective Serotonin Reuptake Inhibitors | 1997 |
125I-iomazenil binding shows stress- and/or diazepam-induced reductions in mouse brain: supporting data for 123I-iomazenil SPECT study of anxiety disorders.
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Autoradiography; Brain; Diazepam; Flumazenil; Iodine Radioisotopes; Male; Mice; Mice, Inbred ICR; Stress, Physiological; Tomography, Emission-Computed, Single-Photon | 1997 |
The direct effects of diazepam and midazolam on myocardial depression in cultured rat ventricular myocytes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Anti-Anxiety Agents; Cells, Cultured; Depression, Chemical; Diazepam; Flumazenil; Heart; Heart Rate; Midazolam; Rats | 1997 |
Comparison of abstinence syndromes precipitated by flumazenil and PK 11195 in female diazepam-dependent rats.
Topics: Animals; Anti-Anxiety Agents; Central Nervous System; Diazepam; Dose-Response Relationship, Drug; Drug Implants; Female; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Isoquinolines; Male; Peripheral Nervous System; Rats; Rats, Sprague-Dawley; Seizures; Sex Characteristics; Substance Withdrawal Syndrome; Substance-Related Disorders | 1997 |
Use of inhalational and intravenous sedation in dentistry.
Topics: Accidents; Anesthesia, Dental; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthesia, Local; Anesthetics, Inhalation; Anesthetics, Intravenous; Anti-Anxiety Agents; Antidotes; Cause of Death; Computers; Conscious Sedation; Dental Care; Diazepam; Drug Overdose; Emergencies; Flumazenil; GABA Modulators; Humans; Hypnotics and Sedatives; Iatrogenic Disease; Infusion Pumps; Isoflurane; Midazolam; Nitrous Oxide; Oxygen; Practice Guidelines as Topic; Propofol; United Kingdom | 1997 |
Interaction between alpha-MSH and gabaergic agents upon striatal cAMP levels: an in vitro model.
Topics: alpha-MSH; Animals; Baclofen; Benzazepines; Corpus Striatum; Cyclic AMP; Diazepam; Drug Interactions; Flumazenil; GABA Agents; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; In Vitro Techniques; Male; Models, Neurological; Rats; Rats, Wistar; Receptors, Dopamine D1 | 1998 |
Neonatal flumazenil therapy reverses maternal diazepam.
Topics: Adult; Anticonvulsants; Antidotes; Apnea; Chromatography, High Pressure Liquid; Diazepam; Eclampsia; Emergency Treatment; Female; Flumazenil; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Pregnancy | 1998 |
The anxiolytic effect of gamma-hydroxybutyrate in the elevated plus maze is reversed by the benzodiazepine receptor antagonist, flumazenil.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Benzocycloheptenes; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; Male; Motor Activity; Naloxone; Narcotic Antagonists; Rats; Sodium Oxybate | 1998 |
The effect of chronic benzodiazepines exposure on body weight in rats.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Body Weight; Diazepam; Dose-Response Relationship, Drug; Female; Flumazenil; Flunitrazepam; GABA Modulators; Male; Nordazepam; Oxazepam; Rats; Rats, Sprague-Dawley; Sex Factors; Time Factors; Weight Gain | 1998 |
Modification of the anxiolytic action of 5-HT1A compounds by GABA-benzodiazepine agents in rats.
Topics: 5-Methoxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Bicuculline; Buspirone; Diazepam; Drug Interactions; Flumazenil; GABA Agonists; Male; Psychomotor Performance; Pyrimidines; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1 | 1998 |
Evidence of GABAergic modulation in melatonin-induced short-term memory deficits and food consumption.
Topics: Animals; Antioxidants; Diazepam; Eating; Female; Flumazenil; GABA Modulators; Latency Period, Psychological; Male; Maze Learning; Melatonin; Memory Disorders; Memory, Short-Term; Mice; Muscarinic Antagonists; Rats; Rats, Wistar; Receptors, GABA; Scopolamine; Triazolam | 1998 |
The octadecaneuropeptide ODN induces anxiety in rodents: possible involvement of a shorter biologically active fragment.
Topics: Amino Acid Sequence; Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Diazepam Binding Inhibitor; Discrimination Learning; Exploratory Behavior; Flumazenil; Injections, Intraventricular; Male; Maze Learning; Mice; Mice, Inbred Strains; Molecular Sequence Data; Neuropeptides; Peptide Fragments; Rats; Rats, Sprague-Dawley; Reaction Time | 1998 |
Oral midazolam: pediatric conscious sedation.
Topics: Administration, Oral; Anesthesia, Dental; Child; Child, Preschool; Conscious Sedation; Dental Anxiety; Dental Care for Children; Diazepam; Flumazenil; GABA Modulators; Humans; Hypnotics and Sedatives; Midazolam | 1998 |
Diazepam-treated female rats: flumazenil- and PK 11195-induced withdrawal in the hippocampus CA1.
Topics: Animals; Anti-Anxiety Agents; Body Weight; Diazepam; Dose-Response Relationship, Drug; Electroencephalography; Female; Flumazenil; GABA Modulators; Hippocampus; Isoquinolines; Microinjections; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1998 |
Behavioural pharmacological characteristics of honokiol, an anxiolytic agent present in extracts of Magnolia bark, evaluated by an elevated plus-maze test in mice.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Bicuculline; Biphenyl Compounds; Caffeine; Central Nervous System Depressants; Central Nervous System Stimulants; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GABA Antagonists; GABA Modulators; Injections, Subcutaneous; Lignans; Male; Maze Learning; Mice; Mice, Inbred BALB C; Motor Activity; Tetragastrin; Therapeutic Equivalency | 1998 |
Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Carbolines; Convulsants; Diazepam; Disease Models, Animal; Electroconvulsive Therapy; Epilepsy; Excitatory Amino Acid Agonists; Flumazenil; GABA-A Receptor Antagonists; Kindling, Neurologic; Levetiracetam; Male; Mice; Pentylenetetrazole; Piracetam; Rats; Rats, Sprague-Dawley; Seizures | 1998 |
Plasma and CSF benzodiazepine receptor ligand concentrations in cirrhotic patients with hepatic encephalopathy: relationship to severity of encephalopathy and to pharmaceutical benzodiazepine intake.
Topics: Animals; Benzodiazepines; Binding, Competitive; Cell Fractionation; Cerebellum; Chronic Disease; Clonazepam; Diazepam; Flumazenil; GABA Modulators; Hepatic Encephalopathy; Humans; Isoquinolines; Liver Cirrhosis; Oxazepam; Radioligand Assay; Rats; Receptors, GABA-A; Tritium | 1998 |
[Characteristics of human lymphocyte benzodiazepine receptors].
Topics: Adult; Baclofen; Benzodiazepinones; Binding, Competitive; Diazepam; Flumazenil; GABA Agonists; gamma-Aminobutyric Acid; Humans; In Vitro Techniques; Ligands; Lymphocytes; Male; Receptors, GABA-A | 1998 |
Inhibitory regulation of amylase release in rat parotid acinar cells by benzodiazepine receptors.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Amylases; Animals; Atropine; Benzodiazepinones; Carbachol; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Isoproterenol; Male; Muscarinic Agonists; Muscarinic Antagonists; Parotid Gland; Propranolol; Rats; Rats, Wistar; Receptors, GABA-A | 1998 |
Effect of benzodiazepines and neurosteroids on ammonia-induced swelling in cultured astrocytes.
Topics: Ammonia; Astrocytes; Atrial Natriuretic Factor; Benzodiazepines; Benzodiazepinones; Brain Edema; Cell Size; Clonazepam; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Diazepam; Diazepam Binding Inhibitor; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Isoquinolines; Nerve Tissue Proteins; Neuropeptides; Peptide Fragments; Pregnanolone; Pregnenolone; Protoporphyrins; Receptors, GABA-A; Steroids; Up-Regulation | 1998 |
Inhibitory effects of diazepam and midazolam on Ca2+ and K+ channels in canine tracheal smooth muscle cells.
Topics: Anesthetics, Intravenous; Animals; Calcium Channel Blockers; Calcium Channels; Diazepam; Dogs; Electrophysiology; Flumazenil; GABA Antagonists; GABA-A Receptor Antagonists; In Vitro Techniques; Isoquinolines; Midazolam; Muscle, Smooth; Patch-Clamp Techniques; Potassium Channel Blockers; Trachea | 1999 |
Cardiac effects of benzodiazepine receptor agonists and antagonists in the isolated rat heart: a comparative study.
Topics: Animals; Benzodiazepines; Cardiac Output; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Female; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Heart; In Vitro Techniques; Isoquinolines; Myocardial Contraction; Perfusion; Pyridines; Rats; Receptors, GABA-A; Zolpidem | 1998 |
The effects of flumazenil on two way active avoidance and locomotor activity in diazepam-treated rats.
Topics: Animals; Anti-Anxiety Agents; Avoidance Learning; Depression, Chemical; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; Injections, Intraperitoneal; Male; Motor Activity; Rats; Rats, Wistar; Time Factors | 1999 |
Behavioral effects of diazepam in the murine plus-maze: flumazenil antagonism of enhanced head dipping but not the disinhibition of open-arm avoidance.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Exploratory Behavior; Flumazenil; GABA Modulators; Grooming; Male; Mice; Mice, Inbred DBA; Motor Activity | 1999 |
Lack of sex differences in anxiety behaviors during precipitated benzodiazepine withdrawal in rats.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Corticosterone; Diazepam; Estradiol; Female; Flumazenil; GABA Modulators; Male; Progesterone; Radioligand Assay; Rats; Rats, Long-Evans; Sex Characteristics; Substance Withdrawal Syndrome | 1999 |
Neurotransmitter modulation of glucocorticoid receptor mRNA levels in the rat hippocampus.
Topics: Adrenergic beta-Antagonists; Animals; Blotting, Northern; Diazepam; Dizocilpine Maleate; Down-Regulation; Excitatory Amino Acid Antagonists; Flumazenil; GABA Modulators; Hippocampus; Injections, Intraperitoneal; Male; Neurotransmitter Agents; Propranolol; Rats; Rats, Wistar; Receptors, Glucocorticoid; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Stress, Psychological | 1999 |
Diazepam reduces action potential duration in guinea-pig papillary muscle by a cAMP-dependent mechanism.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Action Potentials; Animals; Carbachol; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Diazepam; Enzyme Inhibitors; Flumazenil; gamma-Aminobutyric Acid; Guinea Pigs; In Vitro Techniques; Papillary Muscles; Thionucleotides | 1999 |
Modification of the effect of diazepam on the propofol-induced loss of the righting reflex in mice by diabetes.
Topics: Anesthetics, Intravenous; Animals; Diabetes Mellitus, Experimental; Diazepam; Flumazenil; GABA Modulators; Injections, Intravenous; Male; Mice; Mice, Inbred ICR; Posture; Propofol; Receptors, GABA-A; Reflex | 1999 |
Abecarnil enhances recovery from diazepam tolerance.
Topics: Animals; Anticonvulsants; Benzodiazepines; Bicuculline; Carbolines; Cell Membrane; Cerebral Cortex; Clonazepam; Diazepam; Drug Interactions; Drug Tolerance; Flumazenil; Imidazoles; Ligands; Male; Mice; Receptors, GABA-A; Seizures; Tritium | 1999 |
Discriminative stimulus effects of ethyl-beta-carboline-3-carboxylate at two training doses in rats.
Topics: Animals; Carbolines; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1999 |
Anticonflict effects of plant-derived essential oils.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Conflict, Psychological; Diazepam; Drug Interactions; Electroshock; Flumazenil; GABA Modulators; Male; Mice; Mice, Inbred ICR; Oils, Volatile | 1999 |
New evidence that the pharmacological effects of benzodiazepine receptor ligands can be associated with activities at different BZ (omega) receptor subtypes.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Benzodiazepines; Binding, Competitive; Carbolines; Diazepam; Flumazenil; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Hypnotics and Sedatives; Ligands; Male; Mice; Mice, Inbred BALB C; Motor Activity; Muscle Relaxants, Central; Patch-Clamp Techniques; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Zolpidem | 1999 |
Discriminative stimulus effects of flumazenil in untreated and in diazepam-treated rhesus monkeys.
Topics: Animals; Azides; Benzodiazepines; Carbolines; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Modulators; Macaca mulatta; Male; Receptors, GABA-A | 1999 |
Substantia nigra: the involvement of central and peripheral benzodiazepine receptors in physical dependence on diazepam as evidenced by behavioral and EEG effects.
Topics: Animals; Anti-Anxiety Agents; Antineoplastic Agents; Behavior, Animal; Central Nervous System; Diazepam; Dose-Response Relationship, Drug; Drug Implants; Electrodes, Implanted; Electroencephalography; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Isoquinolines; Male; Peripheral Nervous System; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Substance Withdrawal Syndrome; Substance-Related Disorders; Substantia Nigra; Weight Gain | 1999 |
Precipitated withdrawal in the substantia nigra in diazepam-dependent female rats.
Topics: Animals; Anti-Anxiety Agents; Body Weight; Diazepam; Electroencephalography; Female; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Isoquinolines; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Substance-Related Disorders; Substantia Nigra | 1999 |
Central benzodiazepine involvement in clonidine cardiovascular actions.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Atropine Derivatives; Blood Pressure; Carbolines; Cardiovascular Agents; Clonidine; Diazepam; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; Heart Rate; Infusions, Intravenous; Injections, Intraventricular; Male; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Receptors, GABA-A; Stereotaxic Techniques; Time Factors; Yohimbine | 1999 |
Gabaergic-benzodiazepine system is involved in the crotoxin-induced anxiogenic effect.
Topics: Animals; Anxiety; Behavior, Animal; Crotoxin; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Male; Motor Activity; Rats; Rats, Wistar; Receptors, GABA-A | 2000 |
The allocentric place discrimination task is selectively and highly dependent on the central muscarinic system in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Diazepam; Discrimination Learning; Dizocilpine Maleate; Flumazenil; Male; Mecamylamine; Ondansetron; Rats; Rats, Inbred F344; Receptors, Muscarinic; Scopolamine; Swimming | 2000 |
The role of the benzodiazepine-GABA system in the memory processes of the day-old chick.
Topics: Animals; Animals, Newborn; Bicuculline; Chickens; Diazepam; Discrimination, Psychological; Flumazenil; GABA Antagonists; GABA Modulators; Male; Memory; Receptors, GABA-A; Reinforcement, Psychology | 2000 |
Differential sensitivity to Zolpidem of IPSPs activated by morphologically identified CA1 interneurons in slices of rat hippocampus.
Topics: Animals; Diazepam; Evoked Potentials; Flumazenil; GABA Agonists; GABA Modulators; Hippocampus; Interneurons; Male; Presynaptic Terminals; Pyramidal Cells; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Zolpidem | 2000 |
Effect of chronic (-)-nicotine treatment on rat cerebral benzodiazepine receptors.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Diazepam; Flumazenil; Iodine Radioisotopes; Male; Nicotine; Nicotinic Agonists; Radionuclide Imaging; Rats; Rats, Wistar; Receptors, GABA-A; Tissue Distribution | 2000 |
Acute opioid but not benzodiazepine dependence in rats responding for intracranial self-stimulation.
Topics: Animals; Benzodiazepines; Brain; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Male; Morphine; Naltrexone; Opioid-Related Disorders; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Self Stimulation; Substance-Related Disorders | 2000 |
Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.
Topics: Allosteric Site; Animals; Anti-Anxiety Agents; Anticonvulsants; Azides; Benzodiazepines; Binding, Competitive; Brain; Cell Line; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Fluorobenzenes; GABA-A Receptor Antagonists; Hypnotics and Sedatives; Ligands; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Motor Activity; Patch-Clamp Techniques; Receptors, GABA-A; Reflex, Startle; Triazoles | 2000 |
Hypnotic, anticonvulsant and muscle relaxant effects of Rubus brasiliensis. Involvement of GABA(A)-system.
Topics: Animals; Anticonvulsants; Barbiturates; Brazil; Diazepam; Flumazenil; GABA Modulators; Hexanes; Hypnotics and Sedatives; Male; Mice; Muscle Relaxants, Central; Pentylenetetrazole; Plant Extracts; Plants, Medicinal; Receptors, GABA-A; Seizures | 2000 |
Socio-psychological stress-induced antinociception in diabetic mice.
Topics: Animals; Anti-Bacterial Agents; Anticonvulsants; Carbolines; Convulsants; Diabetes Mellitus, Experimental; Diazepam; Flumazenil; GABA Modulators; Male; Mice; Mice, Inbred ICR; Pain Measurement; Streptozocin; Stress, Psychological | 2000 |
Sex-specific effects of in utero manipulation of GABA(A) receptors on pre- and postnatal expression of BDNF in rats.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Diazepam; Female; Flumazenil; GABA Modulators; Gene Expression Regulation, Developmental; Hypothalamus; Male; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Long-Evans; Receptors, GABA-A; RNA, Messenger; Sex Characteristics | 2000 |
Effect of flumazenil and diazepam on transient actions in defensive burying elicited by the social interaction experience in rats.
Topics: Animals; Behavior, Animal; Diazepam; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Male; Rats; Rats, Wistar; Social Behavior; Time Factors | 2000 |
Mice lacking the long splice variant of the gamma 2 subunit of the GABA(A) receptor are more sensitive to benzodiazepines.
Topics: Alternative Splicing; Animals; Azides; Benzodiazepines; Brain; Carbolines; Diazepam; Drug Resistance; Female; Flumazenil; GABA Modulators; Genetic Variation; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Midazolam; Pyridines; Receptors, GABA-A; Sleep; Zolpidem | 2000 |
The influence of the benzodiazepine receptor antagonist flumazenil on the anxiolytic-like effects of CGP 37849 and ACPC in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amino Acids, Cyclic; Animals; Anti-Anxiety Agents; Conflict, Psychological; Diazepam; Dose-Response Relationship, Drug; Drinking Behavior; Electroshock; Excitatory Amino Acid Antagonists; Flumazenil; GABA-A Receptor Antagonists; Male; Maze Learning; Rats; Rats, Wistar; Seizures | 2000 |
Benzodiazepine-sensitive GABA(A) receptors limit the activity of the NMDA/NO/cyclic GMP pathway: a microdialysis study in the cerebellum of freely moving rats.
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Cerebellum; Cyclic GMP; Diazepam; Flumazenil; Infusions, Parenteral; Kinetics; Male; Microdialysis; Muscimol; N-Methylaspartate; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Zolpidem | 2000 |
Antagonism of the discriminative stimulus effects of positive gamma-aminobutyric acid(A) modulators in rhesus monkeys discriminating midazolam.
Topics: Animals; Azides; Benzodiazepines; Carbolines; Diazepam; Discrimination Learning; Drug Antagonism; Female; Flumazenil; GABA Modulators; Macaca mulatta; Male; Midazolam; Receptors, GABA-A | 2000 |
The pharmacodynamics of PK 11195 in diazepam-dependent male and female rats.
Topics: Animals; Anti-Anxiety Agents; Antineoplastic Agents; Body Weight; Brain; Diazepam; Female; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Isoquinolines; Male; Rats; Rats, Sprague-Dawley; Seizures; Sex Characteristics; Substance Withdrawal Syndrome; Substance-Related Disorders | 2000 |
Does dihydrohonokiol, a potent anxiolytic compound, result in the development of benzodiazepine-like side effects?
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Biphenyl Compounds; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Flumazenil; GABA Modulators; Hexobarbital; Hypnotics and Sedatives; Learning; Male; Memory; Mice; Motor Activity; Sleep | 2000 |
Benzodiazepines induce a conformational change in the region of the gamma-aminobutyric acid type A receptor alpha(1)-subunit M3 membrane-spanning segment.
Topics: 4-Chloromercuribenzenesulfonate; Amino Acid Substitution; Animals; Benzodiazepines; Carbolines; Cysteine; Diazepam; Flumazenil; GABA Modulators; Membrane Proteins; Oocytes; Protein Conformation; Rats; Receptors, GABA-A; Xenopus laevis | 2000 |
Flumazenil prevents diazepam-elicited anticonvulsant action and concomitant attenuation of glutamate overflow.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Flumazenil; GABA Modulators; Glutamic Acid; Male; Pilocarpine; Rats; Rats, Wistar; Receptors, GABA-A; Seizures | 2000 |
Anticonflict effect of the glycineB receptor partial agonist, D-cycloserine, in rats. Pharmacological analysis.
Topics: Animals; Anti-Anxiety Agents; Conflict, Psychological; Cycloserine; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 2000 |
Benzodiazepines act on GABAA receptors via two distinct and separable mechanisms.
Topics: Animals; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug; Flumazenil; gamma-Aminobutyric Acid; Membrane Potentials; Mutation; Oocytes; Receptors, GABA-A; RNA, Messenger; Xenopus laevis; Zinc | 2000 |
Diazepam-binding inhibitor-like activity in rat cerebrospinal fluid after stimulation by an aversive quinine taste.
Topics: Animals; Cerebrospinal Fluid; Diazepam; Drinking; Flumazenil; GABA-A Receptor Antagonists; Glutathione; Hydra; Male; Mice; Peptide Fragments; Pronase; Quinine; Rats; Rats, Wistar; Sucrose; Taste | 2000 |
Behaviour of pigs given corticotrophin-releasing hormone in combination with flumazenil or diazepam.
Topics: Animals; Arousal; Corticotropin-Releasing Hormone; Diazepam; Flumazenil; GABA Modulators; Hormone Antagonists; Male; Motor Activity; Peptide Fragments; Receptors, GABA-A; Swine | 2000 |
Evaluation of native GABA(A) receptors containing an alpha 5 subunit.
Topics: Alkynes; Animals; Anti-Anxiety Agents; Anticonvulsants; Autoradiography; Benzodiazepines; Cerebellum; Clobazam; Clonazepam; Diazepam; Flumazenil; Flunitrazepam; GABA-A Receptor Agonists; Hippocampus; Imidazoles; Male; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2001 |
Massive dose of diazepam poisoning.
Topics: Diazepam; Dose-Response Relationship, Drug; Drug Overdose; Flumazenil; Gastric Lavage; Humans; Infusions, Intravenous; Male; Metabolic Clearance Rate; Middle Aged | 1998 |
[3H]Ro 15-1788 binding sites to brain membrane of the saltwater Mugil cephalus.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Carbolines; Cell Membrane; Chlorides; Diazepam; Female; Fishes; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Imidazoles; Ionophores; Male; Pyridines; Receptors, GABA-A; Synaptosomes; Tritium; Zolpidem | 2001 |
Negative inotropic effect of diazepam in isolated guinea pig heart.
Topics: Adjuvants, Anesthesia; Animals; Anti-Arrhythmia Agents; Calcium Channels; Depression, Chemical; Diazepam; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Modulators; Guinea Pigs; Heart; In Vitro Techniques; Isoquinolines; Male; Membrane Potentials; Myocardial Contraction; Patch-Clamp Techniques; Verapamil | 2001 |
Zolpidem, triazolam, and diazepam decrease distress vocalizations in mouse pups: differential antagonism by flumazenil and beta-Carboline-3-carboxylate-t-butyl ester (beta-CCt).
Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Body Temperature; Carbolines; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GABA-A Receptor Antagonists; Mice; Pyridines; Receptors, GABA-A; Triazolam; Vocalization, Animal; Zolpidem | 2001 |
Effects of diazepam and beta-CCM on working memory in mice: relationships with emotional reactivity.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Carbolines; Convulsants; Diazepam; Emotions; Flumazenil; GABA Modulators; Male; Memory; Mice; Mice, Inbred BALB C; Time Factors | 2001 |
Use of negatively reinforcing electrical brain stimulation to detect conventional and nonconventional anxiolytics as well as an anxiogenic drug.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Brain; Buspirone; Carbolines; Convulsants; Diazepam; Electric Stimulation; Electrodes; Flumazenil; GABA Modulators; Male; Pentylenetetrazole; Rats; Rats, Long-Evans; Reinforcement, Psychology | 2001 |
Mice performance on the staircase test following acute ethanol administration.
Topics: Animals; Azides; Benzodiazepines; Central Nervous System Depressants; Diazepam; Dose-Response Relationship, Drug; Ethanol; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred ICR; Psychomotor Performance | 2001 |
Effects of diazepam and flumazenil on minimum alveolar concentrations for dogs anesthetized with isoflurane or a combination of isoflurane and fentanyl.
Topics: Adjuvants, Anesthesia; Anesthetics, Inhalation; Animals; Anti-Anxiety Agents; Blood Pressure; Body Temperature; Diazepam; Dogs; Drug Interactions; Female; Fentanyl; Flumazenil; GABA Modulators; Heart Rate; Isoflurane; Pulmonary Alveoli | 2001 |
Diazepam poisoning with one-month monitoring of diazepam and nordiazepam blood levels.
Topics: Anti-Anxiety Agents; Chromatography, High Pressure Liquid; Diazepam; Flumazenil; Humans; Male; Middle Aged; Nordazepam; Poisoning; Suicide, Attempted; Treatment Outcome | 2001 |
Modification of the effects of benzodiazepines on the exploratory behaviors of mice on a hole-board by diabetes.
Topics: Animals; Anti-Anxiety Agents; Carbolines; Convulsants; Diabetes Mellitus, Experimental; Diazepam; Dose-Response Relationship, Drug; Exploratory Behavior; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; Injections, Intraperitoneal; Male; Mice; Mice, Inbred ICR | 2001 |
Increase in expression of the GABA(A) receptor alpha(4) subunit gene induced by withdrawal of, but not by long-term treatment with, benzodiazepine full or partial agonists.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Cell Membrane; Cells, Cultured; Cerebellum; Chloride Channels; Chlorides; Diazepam; Drug Tolerance; Female; Flumazenil; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Imidazoles; Ion Transport; Membrane Potentials; Microinjections; Nerve Tissue Proteins; Neurons; Oocytes; Protein Subunits; Rats; Receptors, GABA-A; RNA, Messenger; Substance Withdrawal Syndrome; Substance-Related Disorders; Up-Regulation; Xenopus laevis | 2001 |
Diazepam increases the hypothalamic-pituitary-adrenocortical (HPA) axis activity by a cyclic AMP-dependent mechanism.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Corticosterone; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Diazepam; Flumazenil; Hypothalamus; Isoquinolines; Male; Phosphodiesterase Inhibitors; Pituitary Gland; Rats; Rats, Sprague-Dawley; Rolipram; Sulfonamides | 2001 |
Potency of positive gamma-aminobutyric acid(A) modulators to substitute for a midazolam discriminative stimulus in untreated monkeys does not predict potency to attenuate a flumazenil discriminative stimulus in diazepam-treated monkeys.
Topics: Animals; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Modulators; Hypnotics and Sedatives; Macaca mulatta; Male; Midazolam; Receptors, GABA-A; Steroids | 2001 |
Synergistic interaction of diazepam with 3',5'-cyclic adenosine monophosphate-elevating agents on rat aortic rings.
Topics: Animals; Aorta, Thoracic; Colforsin; Cyclic AMP; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Female; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; In Vitro Techniques; Isoproterenol; Isoquinolines; Male; Milrinone; Muscle Relaxants, Central; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phenylephrine; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2001 |
Involvement of benzodiazepine binding sites in an antiaggressive effect by 5-HT(1A) receptor activation in isolated mice.
Topics: Aggression; Animals; Behavior, Animal; Binding Sites; Diazepam; Dioxanes; Dioxoles; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; Male; Mice; Piperazines; Pyridines; Receptors, GABA-A; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Social Isolation | 2001 |
Discriminative stimulus effects of benzodiazepine (BZ)(1) receptor-selective ligands in rhesus monkeys.
Topics: Acetamides; Animals; Carbolines; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Hypnotics and Sedatives; Ligands; Macaca mulatta; Midazolam; Pyridines; Pyrimidines; Receptors, GABA-A; Zolpidem | 2002 |
[Parenteral sedation in oral surgical procedures].
Topics: Antidotes; Benzodiazepines; Conscious Sedation; Diazepam; Flumazenil; Humans; Hypoxia; Infusions, Parenteral; Midazolam; Monitoring, Physiologic; Oral Surgical Procedures; Oximetry | 1996 |
Mechanism of alpha-subunit selectivity of benzodiazepine pharmacology at gamma-aminobutyric acid type A receptors.
Topics: Animals; Anti-Anxiety Agents; Binding, Competitive; Cell Line; Diazepam; Dose-Response Relationship, Drug; Female; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Membrane Potentials; Mutation; Oocytes; Protein Subunits; Pyridazines; Pyridines; Radioligand Assay; Receptors, GABA-A; Tritium; Xenopus laevis; Zolpidem | 2002 |
Evaluation of immunomodulatory potential of Ocimum sanctum seed oil and its possible mechanism of action.
Topics: Adjuvants, Immunologic; Animals; Antibody Formation; Diazepam; Erythrocytes; Flumazenil; Foot; GABA Modulators; Immunity, Cellular; Inflammation; Male; Medicine, Ayurvedic; Mice; Ocimum basilicum; Plant Oils; Rats; Rats, Wistar; Restraint, Physical; Seeds; Sheep; Stress, Physiological | 2002 |
Role of benzodiazepine-GABAA receptor complex in attenuation of U-50,488H-induced analgesia and inhibition of tolerance to its analgesia by ginseng total saponin in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Bicuculline; Diazepam; Dose-Response Relationship, Drug; Drug Antagonism; Drug Tolerance; Drugs, Chinese Herbal; Flumazenil; Ginsenosides; Injections, Intraperitoneal; Male; Mice; Pain; Pain Threshold; Panax; Picrotoxin; Receptors, GABA-A; Receptors, Opioid, kappa; Saponins; Tail | 2002 |
GABA(A)-benzodiazepine receptor complex sensitivity in 5-HT(1A) receptor knockout mice on a 129/Sv background.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Diazepam; Ethanol; Fever; Flumazenil; GABA Antagonists; Hypnotics and Sedatives; Male; Maze Learning; Mice; Mice, Knockout; Pentylenetetrazole; Phenobarbital; Receptors, GABA-A; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Reflex; Species Specificity; Stress, Physiological | 2002 |
The anxiolytic action of mGlu2/3 receptor agonist, LY354740, in the fear-potentiated startle model in rats is mechanistically distinct from diazepam.
Topics: Acoustic Stimulation; Amino Acids; Animals; Anti-Anxiety Agents; Bridged Bicyclo Compounds; Diazepam; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fear; Flumazenil; GABA Modulators; Male; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Reflex, Startle; Xanthenes | 2002 |
Reversal of benzodiazepine-induced renal vasculature relaxation with flumazenil.
Topics: Animals; Clonazepam; Diazepam; Flumazenil; GABA Modulators; Male; Muscle Relaxants, Central; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Rats; Rats, Wistar; Renal Circulation; Vasoconstrictor Agents | 2002 |
Gaba-benzodiazepine receptor complex in brain oxidative metabolism regulation.
Topics: Animals; Diazepam; Flumazenil; Frontal Lobe; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Male; Oxygen Consumption; Picrotoxin; Rats; Rats, Wistar | 2002 |
Diazepam withdrawal-induced anxiety and place aversion in the rat: differential effects of two chronic diazepam treatment regimes.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Conditioning, Operant; Diazepam; Flumazenil; GABA Modulators; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Rats; Rats, Long-Evans; Substance Withdrawal Syndrome | 2002 |
Cardiorespiratory effects of medetomidine-butorphanol, medetomidine-butorphanol-diazepam, and medetomidine-butorphanol-ketamine in captive red wolves (Canis rufus).
Topics: Adrenergic alpha-Antagonists; Anesthetics, Dissociative; Animals; Animals, Zoo; Blood Pressure; Body Temperature; Butorphanol; Diazepam; Drug Combinations; Female; Flumazenil; GABA Modulators; Heart Rate; Hypertension; Hypnotics and Sedatives; Imidazoles; Immobilization; Ketamine; Male; Medetomidine; Muscle Relaxation; Naloxone; Narcotic Antagonists; Narcotics; Respiration; Wolves | 2002 |
Flumazenil in acute benzodiazepine overdose.
Topics: Anti-Anxiety Agents; Antidotes; Diazepam; Female; Flumazenil; Humans; Middle Aged | 2002 |
Flumazenil antagonizes respiratory depression caused by diazepam and induces expiratory excitation of hypoglossal nerve.
Topics: Anesthetics, Intravenous; Animals; Depression, Chemical; Diazepam; Flumazenil; Hypoglossal Nerve; Phrenic Nerve; Pulmonary Ventilation; Rabbits; Respiration | 2002 |
Inhibitory effect of diazepam on muscarinic receptor-stimulated inositol 1,4,5-trisphosphate production in rat parotid acinar cells.
Topics: Animals; Anticonvulsants; Calcium; Carbachol; Chlorides; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; GTP-Binding Proteins; Inositol 1,4,5-Trisphosphate; Isoquinolines; Male; Parotid Gland; Phenylephrine; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Muscarinic; Time Factors | 2002 |
Stereoselective discriminative stimulus effects of zopiclone in rhesus monkeys.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Azabicyclo Compounds; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Macaca mulatta; Male; Midazolam; Piperazines; Stereoisomerism; Substance Withdrawal Syndrome | 2003 |
Effects of cholecystokinin tetrapeptide (CCK(4)) and of anxiolytic drugs on GABA outflow from the cerebral cortex of freely moving rats.
Topics: Adamantane; Animals; Anti-Anxiety Agents; Buspirone; Cerebral Cortex; Diazepam; Epidural Space; Female; Flumazenil; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Male; Motor Activity; Muscle Relaxants, Central; Nerve Tissue Proteins; Phenylurea Compounds; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tetragastrin | 2003 |
Discriminative stimulus effects of positive GABAA modulators and other anxiolytics, sedatives, and anticonvulsants in untreated and diazepam-treated monkeys.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Modulators; Hypnotics and Sedatives; Macaca mulatta; Male; Midazolam; Receptors, GABA-A; Steroids | 2003 |
Effects of diazepam and flumazenil on food competition behavior in high- and low-aggression pigeons.
Topics: Aggression; Animals; Columbidae; Competitive Behavior; Diazepam; Feeding Behavior; Female; Flumazenil | 2003 |
Modulation of development of tolerance to anticonvulsant effect of diazepam by flumazenil.
Topics: Animals; Anticonvulsants; Diazepam; Drug Tolerance; Female; Flumazenil; Male; Mice; Seizures | 2002 |
Role of platelet activating factor in triazolobenzodiazepines-induced retrograde amnesia.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Amnesia, Anterograde; Amnesia, Retrograde; Animals; Anti-Anxiety Agents; Azepines; Diazepam; Diterpenes; Escape Reaction; Female; Flumazenil; Ginkgolides; Lactones; Learning; Male; Mice; Phospholipases A; Platelet Activating Factor; Platelet Membrane Glycoproteins; Reaction Time; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, GABA-A; Retention, Psychology; Triazolam | 2003 |
Involvement of presynaptic 5-HT(1A) and benzodiazepine receptors in the anticonflict activity of 5-HT(1A) receptor antagonists.
Topics: Animals; Anti-Anxiety Agents; Avoidance Learning; Conflict, Psychological; Diazepam; Drinking Behavior; Drug Combinations; Flumazenil; Hippocampus; Injections, Intraperitoneal; Injections, Subcutaneous; Male; p-Chloroamphetamine; Piperazines; Punishment; Pyridines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptors, GABA-A; Receptors, Presynaptic; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Succinimides; Time Factors | 2003 |
Semisynthetic preparation of amentoflavone: A negative modulator at GABA(A) receptors.
Topics: Animals; Biflavonoids; Diazepam; Flowers; Flumazenil; GABA Antagonists; GABA Modulators; Ginkgo biloba; Humans; Hypericum; Magnetic Resonance Spectroscopy; Methylation; Oocytes; Patch-Clamp Techniques; Plant Leaves; Receptors, GABA-A; Recombinant Proteins; Xenopus laevis | 2003 |
Physical dependence in baboons chronically treated with low and high doses of diazepam.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Male; Papio; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 2003 |
Extracts of kava (Piper methysticum) induce acute anxiolytic-like behavioral changes in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GABA-A Receptor Antagonists; Hypnotics and Sedatives; Injections, Intraperitoneal; Kava; Male; Maze Learning; Mice; Mice, Inbred BALB C; Motor Activity; Plant Extracts | 2003 |
Flumazenil attenuates development of tolerance to diazepam after chronic treatment of mice with either isoflurane or diazepam.
Topics: Anesthetics, Inhalation; Animals; Anti-Anxiety Agents; Behavior, Animal; Binding Sites; Diazepam; Drug Tolerance; Flumazenil; GABA Modulators; Isoflurane; Mice; Postural Balance; Receptors, GABA-A | 2003 |
Anticonvulsant and antiepileptogenic effects of GABAA receptor ligands in pentylenetetrazole-kindled mice.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Dehydroepiandrosterone Sulfate; Diazepam; Dose-Response Relationship, Drug; Epilepsy; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; Isoxazoles; Kindling, Neurologic; Ligands; Mice; Pentylenetetrazole; Pregnanediones; Receptors, GABA-A | 2004 |
[How do diazepam and flumazenil influence respiratory control by the activities of both hypoglossal and phrenic nerves in rabbits?].
Topics: Action Potentials; Animals; Diazepam; Flumazenil; Hypoglossal Nerve; Phrenic Nerve; Rabbits; Receptors, GABA-A; Respiration | 2003 |
Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice.
Topics: Animals; Anticonvulsants; Benzoquinones; Diazepam; Electroshock; Flumazenil; GABA Modulators; Injections, Intraperitoneal; Male; Mice; Mice, Inbred BALB C; Motor Activity; Nigella sativa; Pentylenetetrazole; Phytotherapy; Plant Extracts; Seeds; Seizures | 2004 |
Pharmacological plasticity of GABA(A) receptors at dentate gyrus synapses in a rat model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Diazepam; Disease Models, Animal; Electric Conductivity; Epilepsy, Temporal Lobe; Flumazenil; GABA Modulators; Lithium; Male; Neural Inhibition; Patch-Clamp Techniques; Pilocarpine; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Status Epilepticus; Synapses | 2004 |
Benzodiazepine-sensitive GABA(A) receptors in the commissural subnucleus of the NTS are involved in the carotid chemoreceptor reflex in rats.
Topics: Animals; Blood Pressure; Carotid Arteries; Chemoreceptor Cells; Diazepam; Flumazenil; GABA Antagonists; gamma-Aminobutyric Acid; Male; Phrenic Nerve; Rats; Rats, Wistar; Receptors, GABA-A; Reflex; Solitary Nucleus; Synaptic Transmission; Visceral Afferents | 2004 |
Flumazenil-independent positive modulation of gamma-aminobutyric acid action by 6-methylflavone at human recombinant alpha1beta2gamma2L and alpha1beta2 GABAA receptors.
Topics: Allosteric Regulation; Animals; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Female; Flavones; Flavonoids; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Gene Expression; Humans; Membrane Potentials; Microinjections; Molecular Structure; Oocytes; Protein Subunits; Receptors, GABA; Receptors, GABA-A; Recombinant Proteins; RNA; Xenopus laevis | 2004 |
Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA(A) signaling.
Topics: Animals; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Drinking; Drinking Behavior; Drug Interactions; Electroshock; Exploratory Behavior; Flumazenil; GABA Modulators; Male; Maze Learning; Mice; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, GABA-A; Receptors, Metabotropic Glutamate; Sensory Thresholds; Signal Transduction; Thiazoles | 2004 |
[Effect of flumazenil on hypoglossal and phrenic nerves activities in rabbits].
Topics: Action Potentials; Animals; Benzodiazepines; Diazepam; Flumazenil; Hypoglossal Nerve; Male; Phrenic Nerve; Rabbits; Respiration | 2004 |
Chronic exposure of cells expressing recombinant GABAA receptors to benzodiazepine antagonist flumazenil enhances the maximum number of benzodiazepine binding sites.
Topics: Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cell Membrane; Diazepam; Dose-Response Relationship, Drug; Drug Combinations; Flumazenil; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Humans; Kidney; Ligands; Receptors, GABA-A; Recombinant Proteins; Tritium | 2004 |
Acetylcholine in the accumbens is decreased by diazepam and increased by benzodiazepine withdrawal: a possible mechanism for dependency.
Topics: Acetylcholine; Animals; Behavior, Animal; Benzodiazepines; Diazepam; Dopamine; Dose-Response Relationship, Drug; Extracellular Space; Flumazenil; Male; Maze Learning; Microdialysis; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Substance-Related Disorders | 2005 |
Benzodiazepine effect of (125)I-iomazenil-benzodiazepine receptor binding and serum corticosterone level in a rat model.
Topics: Animals; Brain; Corticosterone; Diazepam; Disease Models, Animal; Flumazenil; Male; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Wistar; Receptors, GABA-A; Statistics as Topic; Stress, Psychological; Tissue Distribution | 2005 |
The anxiolytic-like effect of 5-HT1B receptor ligands in rats: a possible mechanism of action.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzamides; Conflict, Psychological; Diazepam; Disease Models, Animal; Drinking Behavior; Drug Administration Schedule; Electroshock; Flumazenil; Men; Neurons; Oxadiazoles; p-Chloroamphetamine; Piperazines; Poland; Pyridines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists; Water | 2005 |
Benzodiazepine system is involved in hyperalgesia in rats induced by the exposure to extremely low frequency magnetic fields.
Topics: Animals; Anti-Anxiety Agents; Baclofen; Bicuculline; Diazepam; Electromagnetic Fields; Flumazenil; GABA Antagonists; GABA Modulators; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; Hot Temperature; Hyperalgesia; Injections, Intraventricular; Male; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, GABA-A | 2005 |
Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats.
Topics: Animals; Anticonvulsants; Benzoquinones; Convulsants; Diazepam; Epilepsy; Flumazenil; Injections, Intraventricular; Male; Nigella; Pentylenetetrazole; Phytotherapy; Rats; Rats, Wistar; Seeds; Seizures | 2005 |
6-Methylflavanone, a more efficacious positive allosteric modulator of gamma-aminobutyric acid (GABA) action at human recombinant alpha2beta2gamma2L than at alpha1beta2gamma2L and alpha1beta2 GABA(A) receptors expressed in Xenopus oocytes.
Topics: Allosteric Regulation; Animals; Diazepam; DNA, Recombinant; Dose-Response Relationship, Drug; Female; Flavanones; Flavones; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Gene Expression; Humans; Membrane Potentials; Microinjections; Oocytes; Protein Isoforms; Receptors, GABA-A; RNA; Xenopus laevis | 2005 |
Characterization in rats of the anxiolytic potential of ELB139 [1-(4-chlorophenyl)-4-piperidin-1-yl-1,5-dihydro-imidazol-2-on], a new agonist at the benzodiazepine binding site of the GABAA receptor.
Topics: Animals; Anti-Anxiety Agents; Binding Sites; Binding, Competitive; Conflict, Psychological; Diazepam; Drug Tolerance; Flumazenil; Flunitrazepam; GABA Agonists; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Imidazoles; Light; Male; Membrane Potentials; Patch-Clamp Techniques; Piperidines; Rats; Rats, Wistar | 2005 |
Design and synthesis of new 2-substituted-5-(2-benzylthiophenyl)-1,3,4-oxadiazoles as benzodiazepine receptor agonists.
Topics: Animals; Anticonvulsants; Benzodiazepines; Convulsants; Diazepam; Drug Design; Electroshock; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; Mice; Models, Molecular; Molecular Structure; Oxadiazoles; Pentylenetetrazole; Seizures; Structure-Activity Relationship | 2005 |
Chronic treatment with flumazenil enhances binding sites for convulsants at recombinant alpha(1)beta(2)gamma(2S) GABA(A) receptors.
Topics: Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Convulsants; Diazepam; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Humans; Receptors, GABA-A; Recombinant Proteins | 2005 |
GABA(A) receptors mediate orexin-A induced stimulation of food intake.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Eating; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; GABA-A Receptor Antagonists; Hyperphagia; Injections, Intraventricular; Intracellular Signaling Peptides and Proteins; Male; Muscimol; Neuropeptides; Orexin Receptors; Orexins; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, GABA-A; Receptors, Neuropeptide; Stimulation, Chemical | 2006 |
Influence of adenosine receptor agonists on benzodiazepine withdrawal signs in mice.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Male; Mice; Pentylenetetrazole; Phenethylamines; Purinergic Agonists; Purinergic P1 Receptor Agonists; Purinergic P2 Receptor Agonists; Seizures; Substance Withdrawal Syndrome; Temazepam | 2005 |
Diazepam inhibits the induction and maintenance of LTP of C-fiber evoked field potentials in spinal dorsal horn of rats.
Topics: Animals; Diazepam; Electrophysiology; Evoked Potentials; Flumazenil; GABA Modulators; Hypnotics and Sedatives; Long-Term Potentiation; Male; Nerve Fibers, Unmyelinated; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Taurine | 2006 |
Cardiotonic and sedative effects of Cecropia pachystachya Mart. (ambay) on isolated rat hearts and conscious mice.
Topics: Amphetamine; Animals; Argentina; Benzodiazepines; Cardiotonic Agents; Cardiovascular Agents; Cecropia Plant; Chromatography, High Pressure Liquid; Diazepam; Dopamine; Female; Flumazenil; Heart; Heart Rate; Hypnotics and Sedatives; Male; Mice; Plant Extracts; Rats; Rats, Wistar; Receptors, GABA-A | 2006 |
Involvement of diazepam-insensitive benzodiazepine receptors in the suppression of DOI-induced head-twitch responses in diabetic mice.
Topics: Amphetamines; Animals; Azides; Behavior, Animal; Benzodiazepines; Bicuculline; Diabetes Mellitus, Experimental; Diazepam; Flumazenil; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Male; Mice; Mice, Inbred ICR; Receptors, GABA-A; Serotonin Receptor Agonists | 2006 |
Effects of drugs acting on the GABA-benzodiazepine receptor complex on flurothyl-induced seizures in Mongolian gerbils.
Topics: Amino Acids; Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Ethanol; Flumazenil; Flurothyl; GABA Antagonists; GABA-A Receptor Antagonists; Gerbillinae; Male; Picrotoxin; Receptors, GABA-A; Seizures; Valproic Acid | 2006 |
Protective effect of BR-16A, a polyherbal preparation against social isolation stress: possible GABAergic mechanism.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Female; Flumazenil; GABA Agonists; gamma-Aminobutyric Acid; Male; Mice; Motor Activity; Pain; Pentobarbital; Phytotherapy; Plant Extracts; Social Isolation; Stress, Psychological | 2006 |
Efficacy and the discriminative stimulus effects of negative GABAA modulators, or inverse agonists, in diazepam-treated rhesus monkeys.
Topics: Animals; Azides; Benzodiazepines; Conditioning, Operant; Cues; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Agonists; GABA Modulators; Hypnotics and Sedatives; Macaca mulatta; Male; Pentobarbital; Pregnanolone; Receptors, GABA-A | 2006 |
Enhanced sucrose pellet consumption induced by benzodiazepine-type drugs in squirrel monkeys: role of GABAA receptor subtypes.
Topics: Alprazolam; Animals; Benzodiazepines; Diazepam; Flumazenil; Male; Pyridines; Receptors, GABA-A; Saimiri; Sucrose; Zolpidem | 2006 |
GABAA receptor regulation of voluntary ethanol drinking requires PKCepsilon.
Topics: Alcohol Drinking; Animals; Diazepam; Flumazenil; GABA Agonists; GABA Modulators; Hypnotics and Sedatives; Mice; Mice, Knockout; Motor Activity; Protein Kinase C-epsilon; Pyridines; Receptors, GABA-A; Zolpidem | 2006 |
Effects of genetic background and null mutation of 5-HT1A receptors on basal and stress-induced body temperature: modulation by serotonergic and GABAA-ergic drugs.
Topics: Animals; Body Temperature; Body Temperature Regulation; Buspirone; Diazepam; Fever; Flumazenil; Fluorobenzenes; GABA Agonists; GABA Modulators; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pyridines; Receptor, Serotonin, 5-HT1A; Receptors, GABA-A; Serotonin; Serotonin Agents; Serotonin Receptor Agonists; Stress, Psychological; Triazoles; Zolpidem | 2006 |
Felbamate is a subunit selective modulator of recombinant gamma-aminobutyric acid type A receptors expressed in Xenopus oocytes.
Topics: Animals; Cells, Cultured; Cerebellum; Diazepam; DNA, Recombinant; Felbamate; Female; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Gene Expression; Humans; Membrane Potentials; Oocytes; Patch-Clamp Techniques; Phenylcarbamates; Plasmids; Propylene Glycols; Protein Subunits; Receptors, GABA-A; Xenopus laevis | 2006 |
Anti-anxiety effects of Apocynum venetum L. in the elevated plus maze test.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Apocynum; Behavior, Animal; Buspirone; Diazepam; Disease Models, Animal; Ethanol; Flumazenil; GABA Modulators; Male; Maze Learning; Mice; Mice, Inbred C57BL; Piperazines; Plant Extracts; Plants, Medicinal; Pyridines; Receptors, GABA; Serotonin Antagonists | 2007 |
Effects of diazepam on 125I-iomazenil-benzodiazepine receptor binding and epileptic seizures in the El mouse.
Topics: Animals; Anticonvulsants; Autoradiography; Brain; Diazepam; Disease Models, Animal; Epilepsy; Flumazenil; Iodine Radioisotopes; Mice; Protein Binding; Receptors, GABA-A; Seizures; Time Factors | 2006 |
A possible mechanism for anxiolytic and antidepressant effects of alpha- and beta-amyrin from Protium heptaphyllum (Aubl.) March.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; Burseraceae; Diazepam; Flumazenil; GABA Modulators; Hypnotics and Sedatives; Imipramine; Mice; Oleanolic Acid; Plant Preparations; Reserpine | 2006 |
Pharmacological analysis of the effects of benzodiazepines on punished schedule-induced polydipsia in rats.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Chlordiazepoxide; Diazepam; Dose-Response Relationship, Drug; Drinking; Electroshock; Fear; Flumazenil; Food Deprivation; GABA Modulators; Imidazoles; Male; Oxazepam; Punishment; Pyrimidines; Rats; Rats, Wistar; Receptors, GABA-A; Reinforcement Schedule | 2007 |
Changes in relative potency among positive GABA(A) receptor modulators upon discontinuation of chronic benzodiazepine treatment in rhesus monkeys.
Topics: Animals; Behavior, Animal; Benzodiazepines; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Modulators; Lorazepam; Macaca mulatta; Male; Midazolam; Pentobarbital; Pregnanediones; Pregnanolone; Receptors, GABA-A; Substance Withdrawal Syndrome | 2007 |
Neuroprotection afforded by diazepam against oxygen/glucose deprivation-induced injury in rat cortical brain slices.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; Glucose; Hypoxia, Brain; Male; Neurons; Neuroprotective Agents; Oxygen; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2007 |
Allosteric uncoupling and up-regulation of benzodiazepine and GABA recognition sites following chronic diazepam treatment of HEK 293 cells stably transfected with alpha1beta2gamma2S subunits of GABA (A) receptors.
Topics: Allosteric Regulation; Animals; Benzodiazepines; Binding Sites; Binding, Competitive; Cell Line; Diazepam; Flumazenil; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Muscimol; Picrotoxin; Protein Subunits; Pyridazines; Radioligand Assay; Rats; Receptors, GABA-A; Receptors, GABA-B; Transfection; Up-Regulation | 2007 |
Anxiolytic-like effects of sinapic acid in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Bicuculline; Cerebral Cortex; Chloride Channels; Coumaric Acids; Diazepam; Electrophysiology; Flumazenil; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred ICR; Motor Activity; Muscle Relaxation; Muscle, Smooth; Neurons; Neurotransmitter Agents; Piperazines; Postural Balance; Pyridines; Serotonin Antagonists | 2007 |
Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors.
Topics: Animals; Anticonvulsants; Antidotes; Convulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy, Absence; Flumazenil; Injections, Intraperitoneal; Male; Mice; Mice, Inbred BALB C; Naloxone; Narcotic Antagonists; Passiflora; Pentylenetetrazole; Phytotherapy; Plant Components, Aerial; Plant Extracts; Receptors, GABA-A; Receptors, Opioid; Sodium Chloride; Treatment Outcome | 2007 |
Effect of withdrawal of diazepam or morphine treatment on gastric motility (charcoal meal test) in mice: possible role of different central and peripheral receptors.
Topics: Analgesics; Analgesics, Opioid; Animals; Central Nervous System; Chemistry, Pharmaceutical; Diazepam; Drug Evaluation, Preclinical; Flumazenil; Gastric Mucosa; Male; Mice; Morphine; Naloxone; Peripheral Nervous System; Stomach; Substance Withdrawal Syndrome | 2007 |
Treatment with haloperidol and diazepam alters GABA(A) receptor density in the rat brain.
Topics: Animals; Antipsychotic Agents; Autoradiography; Benzodiazepines; Binding Sites; Brain; Diazepam; Disease Models, Animal; Drug Combinations; Flumazenil; Haloperidol; Hippocampus; Humans; Injections, Intraperitoneal; Muscimol; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Schizophrenia; Thalamus; Tissue Distribution | 2008 |
The anxiolytic-like effect of the selective 5-HT6 receptor antagonist SB-399885: the impact of benzodiazepine receptors.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Behavior, Animal; Conflict, Psychological; Diazepam; Dose-Response Relationship, Drug; Drinking; Electroshock; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Injections, Intraperitoneal; Male; p-Chloroamphetamine; Piperazines; Rats; Rats, Wistar; Receptors, GABA; Receptors, GABA-A; Receptors, Serotonin; Serotonin Antagonists; Sulfonamides | 2008 |
Reduced GABA neurotransmission underlies hyperalgesia induced by repeated forced swimming stress.
Topics: Analysis of Variance; Animals; Diazepam; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Hyperalgesia; Male; Microdialysis; Pain; Pain Threshold; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Spinal Cord; Stress, Psychological; Swimming | 2008 |
Reversal of paradoxical excitement to diazepam sedation.
Topics: Anti-Anxiety Agents; Antidotes; Child; Conscious Sedation; Diazepam; Flumazenil; Humans; Male; Psychomotor Agitation; Treatment Outcome | 2008 |
Long-lasting modulation of glutamatergic transmission in VTA dopamine neurons after a single dose of benzodiazepine agonists.
Topics: Animals; Benzodiazepines; Diazepam; Dizocilpine Maleate; Ethanol; Excitatory Postsynaptic Potentials; Female; Flumazenil; GABA-A Receptor Agonists; Glutamic Acid; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Morphine; Neurons; Patch-Clamp Techniques; Pyridines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Ventral Tegmental Area; Zolpidem | 2009 |
Anxiolytic activity of a phytochemically characterized Passiflora incarnata extract is mediated via the GABAergic system.
Topics: Animals; Anti-Anxiety Agents; Buspirone; Chromatography, High Pressure Liquid; Diazepam; Flavonoids; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Maze Learning; Mice; Mice, Inbred C57BL; Passiflora; Phytotherapy; Piperazines; Plant Extracts; Pyridines; Serotonin Antagonists | 2008 |
GABAA receptor alpha5 subunits contribute to GABAA,slow synaptic inhibition in mouse hippocampus.
Topics: Animals; Biophysical Phenomena; Biophysics; Diazepam; Electric Stimulation; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Mice; Mice, Transgenic; Neural Inhibition; Patch-Clamp Techniques; Point Mutation; Pyramidal Cells; Receptors, GABA-A; Synapses | 2009 |
A high-throughput functional assay for characterization of gamma-aminobutyric acid(A) channel modulators using cryopreserved transiently transfected cells.
Topics: Carbolines; Cell Culture Techniques; Cell Line; Cell Membrane; Cryopreservation; Diazepam; DNA; Dose-Response Relationship, Drug; Drug Discovery; Flumazenil; Flunitrazepam; Fluorescent Dyes; Fluorobenzenes; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Membrane Potentials; Receptors, GABA-A; Reproducibility of Results; Spectrometry, Fluorescence; Transfection; Triazoles; Tritium | 2008 |
[Pharmacodynamic and pharmacokinetic effects of flumazenil and theophylline application in rats acutely intoxicated by diazepam].
Topics: Animals; Antidotes; Diazepam; Flumazenil; GABA Modulators; Hypnotics and Sedatives; Male; Motor Activity; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Theophylline | 2009 |
The effects of benzodiazepines on urotensin II-stimulated norepinephrine release from rat cerebrocortical slices.
Topics: Animals; Benzodiazepines; Benzoxazoles; Calcium Signaling; Cell Line; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; GABA-A Receptor Agonists; Humans; Hypnotics and Sedatives; In Vitro Techniques; Male; Midazolam; Naphthyridines; Norepinephrine; Orexin Receptors; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, GABA-A; Receptors, Neuropeptide; Transfection; Urea; Urotensins | 2009 |
Kaempferol from the leaves of Apocynum venetum possesses anxiolytic activities in the elevated plus maze test in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Apocynum; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Kaempferols; Male; Maze Learning; Mice; Mice, Inbred BALB C; Phytotherapy; Piperazines; Plant Extracts; Plant Leaves; Pyridines | 2009 |
Central action of Araucaria angustifolia seed lectin in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Flumazenil; Lectins; Locomotion; Male; Mice; Pentylenetetrazole; Phytotherapy; Plant Extracts; Reaction Time; Seeds; Seizures; Strychnine | 2009 |
A novel operant conflict procedure using incrementing shock intensities to assess the anxiolytic and anxiogenic effects of drugs.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Aripiprazole; Benzodiazepines; Chlordiazepoxide; Conditioning, Operant; Conflict, Psychological; Dextroamphetamine; Diazepam; Electroshock; Flumazenil; Male; Piperazines; Punishment; Pyridazines; Quinolones; Rats; Rats, Sprague-Dawley; Triazoles; Yohimbine | 2009 |
Impairment of the cortical GABAergic inhibitory system in catatonic stupor: a case report with neuroimaging.
Topics: Acute Disease; Adult; Catatonia; Cerebral Cortex; Diazepam; Electroencephalography; Encephalitis; Flumazenil; Fluorodeoxyglucose F18; Frontal Lobe; Functional Laterality; GABA Modulators; Glucose; Humans; Male; Positron-Emission Tomography; Radiopharmaceuticals; Stupor; Temporal Lobe; Tomography, Emission-Computed, Single-Photon | 2009 |
Relative positioning of diazepam in the benzodiazepine-binding-pocket of GABA receptors.
Topics: Allosteric Regulation; Animals; Anti-Anxiety Agents; Benzodiazepines; Binding Sites; Biophysics; Cell Line, Transformed; Cysteine; Diazepam; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electric Stimulation; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Humans; Membrane Potentials; Oocytes; Point Mutation; Protein Binding; Receptors, GABA-A; Structure-Activity Relationship; Transfection; Xenopus | 2009 |
Discriminative stimulus effects of L-838,417 (7-tert-butyl-3-(2,5-difluoro-phenyl)-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-[1,2,4]triazolo[4,3-b]pyridazine): role of GABA(A) receptor subtypes.
Topics: Animals; Barbiturates; Carbolines; Catheterization; Central Nervous System Depressants; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Ethanol; Flumazenil; Fluorobenzenes; GABA Agonists; GABA Antagonists; GABA Modulators; Neuropsychological Tests; Pyridines; Receptors, GABA-A; Saimiri; Triazoles; Zolpidem | 2010 |
Neurosteroid withdrawal regulates GABA-A receptor α4-subunit expression and seizure susceptibility by activation of progesterone receptor-independent early growth response factor-3 pathway.
Topics: Animals; Diazepam; Drug Administration Schedule; Early Growth Response Protein 3; Female; Flumazenil; Gene Expression Regulation; Hippocampus; Kindling, Neurologic; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurotransmitter Agents; Oligodeoxyribonucleotides, Antisense; Pregnanolone; Progesterone; Receptors, GABA-A; Receptors, Progesterone; Signal Transduction; Up-Regulation | 2010 |
Metabotropic glutamate receptor 4 novel agonist LSP1-2111 with anxiolytic, but not antidepressant-like activity, mediated by serotonergic and GABAergic systems.
Topics: Aminobutyrates; Animals; Anti-Anxiety Agents; Antidepressive Agents; Diazepam; Fever; Flumazenil; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Maze Learning; Mice; Phosphinic Acids; Piperazines; Pyridines; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptors, GABA-A; Receptors, Metabotropic Glutamate; Ritanserin; Serotonin; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT2 Receptor Agonists; Stress, Psychological | 2010 |
Diazepam decreases action potential firing of neocortical neurons via two distinct mechanisms.
Topics: Action Potentials; Anesthetics; Animals; Binding Sites; Diazepam; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Modulators; Hypnotics and Sedatives; Male; Mice; Mice, Inbred C57BL; Neocortex; Neural Inhibition; Neurons; Receptors, GABA-A; Time Factors; Tissue Culture Techniques | 2010 |
Chronic benzodiazepine treatment does not alter interactions between positive GABA(A) modulators and flumazenil or pentylenetetrazole in monkeys.
Topics: Animals; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Interactions; Female; Flumazenil; GABA Modulators; Macaca mulatta; Male; Midazolam; Pentylenetetrazole; Receptors, GABA-A | 2011 |
Sedative effects of Iranian Artemisia annua in mice: possible benzodiazepine receptors involvement.
Topics: Acetates; Alkanes; Animals; Antidotes; Antimalarials; Artemisia annua; Artemisinins; Chloroform; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Hypnotics and Sedatives; Immobilization; Iran; Male; Mice; Phytotherapy; Plant Components, Aerial; Plant Extracts; Receptors, GABA-A; Solvents | 2011 |
Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord.
Topics: Analgesics; Animals; Diazepam; Disease Models, Animal; Excitatory Postsynaptic Potentials; Flumazenil; Formaldehyde; GABA Modulators; gamma-Aminobutyric Acid; Glutamic Acid; Hyperalgesia; Ketamine; Male; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Stress, Psychological; Swimming; Time Factors | 2011 |
3-Hydroxy-2'-methoxy-6-methylflavone: a potent anxiolytic with a unique selectivity profile at GABA(A) receptor subtypes.
Topics: Animals; Anti-Anxiety Agents; Diazepam; Dose-Response Relationship, Drug; Fatty Acids, Volatile; Flavones; Flumazenil; gamma-Aminobutyric Acid; Humans; Male; Mice; Mice, Inbred BALB C; Molecular Structure; Motor Activity; Oocytes; Pentylenetetrazole; Receptors, GABA-A; Recombinant Proteins; Thiopental; Xenopus | 2011 |
The role of α1 and α5 subunit-containing GABAA receptors in motor impairment induced by benzodiazepines in rats.
Topics: Animals; Ataxia; Benzodiazepines; Benzodiazepinones; Carbolines; Diazepam; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Hand Strength; Imidazoles; Male; Muscle Relaxation; Pyridines; Rats; Rats, Wistar; Receptors, GABA-A; Rotarod Performance Test; Zolpidem | 2012 |
Evaluation of acute toxicity of a natural compound (+)-limonene epoxide and its anxiolytic-like action.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Cyclohexane Monoterpenes; Diazepam; Dose-Response Relationship, Drug; Female; Flumazenil; Hypnotics and Sedatives; Injections, Intraperitoneal; Male; Mice; Monoterpenes; Motor Activity; Postural Balance; Stereoisomerism | 2012 |
Participation of the GABAergic system in the anesthetic effect of Lippia alba (Mill.) N.E. Brown essential oil.
Topics: Anesthetics; Animals; Catfishes; Diazepam; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Lippia; Models, Animal; Oils, Volatile; Plant Leaves; Receptors, GABA-A | 2012 |
Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, induces sleep via the benzodiazepine site of GABA(A) receptor in mice.
Topics: Animals; Arousal; Biphenyl Compounds; Diazepam; Drug Interactions; Electroencephalography; Electromyography; Flumazenil; GABA Modulators; Gene Expression; Genes, fos; Hypothalamic Area, Lateral; Immunohistochemistry; Lignans; Magnolia; Male; Mice; Mice, Inbred C57BL; Plant Bark; Polysomnography; Preoptic Area; Receptors, GABA-A; Sleep; Sleep, REM | 2012 |
GABA(A) receptor α subunits differentially contribute to diazepam tolerance after chronic treatment.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Benzodiazepinones; Body Temperature; Brain; Diazepam; DNA Primers; Drug Tolerance; Flumazenil; Hypnotics and Sedatives; In Situ Hybridization; Male; Mice; Mice, Mutant Strains; Pyridazines; Pyridines; Receptors, GABA-A; Triazoles; Zolpidem | 2012 |
Effects of diazepam and flumazenil on forebrain ischaemia in a rat model of benzodiazepine tolerance.
Topics: Analysis of Variance; Animals; Benzodiazepines; Brain Ischemia; Diazepam; Disease Models, Animal; Drug Tolerance; Flumazenil; GABA Modulators; Male; Neuroprotective Agents; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Severity of Illness Index | 2012 |
βCCT, an antagonist selective for α(1)GABA(A) receptors, reverses diazepam withdrawal-induced anxiety in rats.
Topics: Animals; Anxiety; Carbolines; Diazepam; Flumazenil; GABA-A Receptor Antagonists; Hypnotics and Sedatives; Male; Maze Learning; Rats; Rats, Wistar; Receptors, GABA-A; Substance Withdrawal Syndrome | 2013 |
Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms.
Topics: Alkaloids; Amino Acids; Animals; Anticonvulsants; Antioxidants; Atropine; Benzodioxoles; Biogenic Monoamines; Brain; Diazepam; Disease Models, Animal; Epilepsy; Flumazenil; gamma-Aminobutyric Acid; Humans; Male; Memantine; Mice; Nimodipine; Nitrites; Pilocarpine; Piperidines; Polyunsaturated Alkamides; Seizures; Tumor Necrosis Factor-alpha | 2013 |
Potentiating effect of glabridin on GABAA receptor-mediated responses in dorsal raphe neurons.
Topics: Animals; Anti-Anxiety Agents; Brain; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GABA Agents; gamma-Aminobutyric Acid; Glycyrrhiza; Hypnotics and Sedatives; Isoflavones; Neurons; Pentobarbital; Phenols; Plant Extracts; Plant Roots; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Zolpidem | 2013 |
A possible mechanism for the anxiolytic-like effect of gallic acid in the rat elevated plus maze.
Topics: Animals; Anti-Anxiety Agents; Buspirone; Diazepam; Flumazenil; Gallic Acid; Male; Maze Learning; Rats; Rats, Wistar | 2014 |
Potential antioxidant and anxiolytic effects of (+)-limonene epoxide in mice after marble-burying test.
Topics: Animals; Anti-Anxiety Agents; Antioxidants; Anxiety; Catalase; Cyclohexane Monoterpenes; Diazepam; Flumazenil; Free Radical Scavengers; Hippocampus; Male; Mice; Monoterpenes; Reactive Nitrogen Species; Reactive Oxygen Species; Superoxide Dismutase | 2014 |
Marine polyphenol phlorotannins promote non-rapid eye movement sleep in mice via the benzodiazepine site of the GABAA receptor.
Topics: Animals; Diazepam; Dioxanes; Dose-Response Relationship, Drug; Electroencephalography; Flumazenil; Heterocyclic Compounds, 4 or More Rings; Hypnotics and Sedatives; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Polyphenols; Receptors, GABA-A; Sleep; Tannins | 2014 |
S-(+)-Linalool from Lippia alba: sedative and anesthetic for silver catfish (Rhamdia quelen).
Topics: Acyclic Monoterpenes; Anesthesia; Anesthetics; Animals; Catfishes; Central Nervous System; Diazepam; Flumazenil; Hypnotics and Sedatives; Lippia; Monoterpenes; Plant Oils | 2014 |
Effects of chronic mild stress on the development of drug dependence in rats.
Topics: Animals; Chronic Disease; Citalopram; Depressive Disorder; Diazepam; Disease Models, Animal; Flumazenil; GABA Modulators; Male; Mecamylamine; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Stress, Psychological; Substance Withdrawal Syndrome; Substance-Related Disorders | 2014 |
Potential mechanisms involved in the anticonvulsant effect of walnut extract on pentylenetetrazole-induced seizure.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Ethosuximide; Flumazenil; Juglans; Male; Pentylenetetrazole; Plant Extracts; Rats; Rats, Wistar; Seizures | 2014 |
Women with PTSD have a changed sensitivity to GABA-A receptor active substances.
Topics: Adolescent; Adult; Anxiety; Diagnostic and Statistical Manual of Mental Disorders; Diazepam; Female; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; Humans; Hypnotics and Sedatives; Pregnanolone; Psychiatric Status Rating Scales; Receptors, GABA-A; Saccades; Stress Disorders, Post-Traumatic; Young Adult | 2016 |
Positive modulation of synaptic and extrasynaptic GABAA receptors by an antagonist of the high affinity benzodiazepine binding site.
Topics: Allosteric Regulation; Animals; Benzodiazepines; Binding Sites; Diazepam; Flumazenil; GABA Agents; gamma-Aminobutyric Acid; HEK293 Cells; Humans; Membrane Potentials; Mutation; Neurons; Oocytes; Patch-Clamp Techniques; Protein Isoforms; Quinolines; Radioligand Assay; Receptors, GABA-A; Recombinant Proteins; Thiazoles; Transfection; Xenopus laevis | 2015 |
Negative allosteric modulation of GABAA receptors inhibits facilitation of brain stimulation reward by drugs of abuse in C57BL6/J mice.
Topics: Allosteric Regulation; Animals; Azides; Benzodiazepines; Brain; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Illicit Drugs; Male; Mice; Mice, Inbred C57BL; Microdialysis; Receptors, GABA-A; Reward; Self Stimulation | 2016 |
Effect of (+)-dehydrofukinone on GABAA receptors and stress response in fish model.
Topics: Anesthetics; Animals; Catfishes; Diazepam; Flame Ionization; Flumazenil; GABA Modulators; Gas Chromatography-Mass Spectrometry; Hydrocortisone; Hypnotics and Sedatives; Lauraceae; Oils, Volatile; Plant Extracts; Plant Leaves; Receptors, GABA-A; Sesquiterpenes; Stress, Physiological | 2016 |
A microPET comparison of the effects of etifoxine and diazepam on [(11)C]flumazenil uptake in rat brains.
Topics: Animals; Anti-Anxiety Agents; Brain; Carbon Isotopes; Diazepam; Flumazenil; Magnetic Resonance Imaging; Male; Oxazines; Positron-Emission Tomography; Protein Binding; Radiopharmaceuticals; Rats, Wistar; Receptors, GABA-A | 2016 |
Inhibition of Neuropathic Pain by a Single Intraperitoneal Injection of Diazepam in the Rat: Possible Role of Neurosteroids.
Topics: Animals; Benzodiazepinones; Carrier Proteins; Diazepam; Flumazenil; Injections, Intraperitoneal; Interleukin-1beta; Male; Neuralgia; Neurotransmitter Agents; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2016 |
Determination of flumazenil in serum by liquid chromatography-mass spectrometry: Application to kinetics study in acute diazepam overdose.
Topics: Aminophylline; Antidotes; Chromatography, Liquid; Diazepam; Dimensional Measurement Accuracy; Dose-Response Relationship, Drug; Drug Interactions; Drug Overdose; Flumazenil; Half-Life; Humans; Hypnotics and Sedatives; Mass Spectrometry; Phosphodiesterase Inhibitors; Reproducibility of Results | 2016 |
Benzodiazepine poisoning in elderly.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Antidotes; Benzodiazepines; Bromazepam; Cohort Studies; Coma; Diazepam; Drug Overdose; Female; Flumazenil; Humans; Incidence; Length of Stay; Lorazepam; Male; Middle Aged; Pneumonia, Aspiration; Respiratory Insufficiency; Retrospective Studies; Serbia; Suicide, Attempted; Young Adult | 2016 |
Kavain, the Major Constituent of the Anxiolytic Kava Extract, Potentiates GABAA Receptors: Functional Characteristics and Molecular Mechanism.
Topics: Anesthetics; Animals; Anti-Anxiety Agents; Benzodiazepines; Diazepam; Drug Interactions; Drug Synergism; Etomidate; Flumazenil; Humans; Kava; Mutation; Propofol; Protein Subunits; Pyrones; Receptors, GABA-A; Xenopus laevis | 2016 |
Diazepam Inhibits Electrically Evoked and Tonic Dopamine Release in the Nucleus Accumbens and Reverses the Effect of Amphetamine.
Topics: Amphetamine; Analysis of Variance; Animals; Central Nervous System Stimulants; Diazepam; Dopamine; Dose-Response Relationship, Drug; Electric Stimulation; Electrochemical Techniques; Flumazenil; GABA Modulators; Mice; Microdialysis; Nucleus Accumbens | 2017 |
The anxiolytic-like effect of rutin in rats involves GABAA receptors in the basolateral amygdala.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Basolateral Nuclear Complex; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; Male; Maze Learning; Rats; Rats, Wistar; Receptors, GABA-A; Rutin | 2017 |
Curcumol allosterically modulates GABA(A) receptors in a manner distinct from benzodiazepines.
Topics: Allosteric Regulation; Animals; Benzodiazepines; CA1 Region, Hippocampal; Cells, Cultured; Diazepam; Drugs, Chinese Herbal; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; HEK293 Cells; Humans; Membrane Potentials; Pyramidal Cells; Receptors, GABA-A; Sesquiterpenes | 2017 |
Intra-hippocampal microinjection of oxytocin produced antiepileptic effect on the pentylenetetrazol-induced epilepsy in rats.
Topics: Animals; Anticonvulsants; Diazepam; Epilepsy; Flumazenil; Hippocampus; Male; Microinjections; Oxytocics; Oxytocin; Pentylenetetrazole; Rats; Tocolytic Agents; Vasotocin | 2017 |
Diazepam Concurrently Increases the Frequency and Decreases the Amplitude of Transient Dopamine Release Events in the Nucleus Accumbens.
Topics: Animals; Diazepam; Dopamine; Flumazenil; Male; Nucleus Accumbens; Rats; Time Factors | 2018 |
The anxiolytic-like effect of 6-styryl-2-pyrone in mice involves GABAergic mechanism of action.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Hippocampus; Imipramine; Male; Mice; Pyrones; Styrenes | 2018 |
Subregion-Specific Impacts of Genetic Loss of Diazepam Binding Inhibitor on Synaptic Inhibition in the Murine Hippocampus.
Topics: Animals; Central Nervous System Agents; Diazepam; Diazepam Binding Inhibitor; Female; Flumazenil; Hippocampus; Inhibitory Postsynaptic Potentials; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Miniature Postsynaptic Potentials; Neurons; Receptors, GABA-A; Tissue Culture Techniques | 2018 |
Gephyrin Palmitoylation in Basolateral Amygdala Mediates the Anxiolytic Action of Benzodiazepine.
Topics: Acyltransferases; Animals; Anti-Anxiety Agents; Anxiety; Basolateral Nuclear Complex; Benzodiazepines; Diazepam; Flumazenil; Gene Knockdown Techniques; Lipoylation; Male; Membrane Proteins; Rats; Receptors, GABA-A | 2019 |
Biological profiling of piperazinediones for the management of anxiety.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Benzodiazepines; Catalytic Domain; Diazepam; Diketopiperazines; Flumazenil; GABA Modulators; Hypnotics and Sedatives; Male; Maze Learning; Models, Animal; Norepinephrine; Rats; Rats, Wistar; Receptors, GABA-A; Serotonin | 2019 |
Benzodiazepines Suppress Neuromodulatory Effects of Pudendal Nerve Stimulation on Rat Bladder Nociception.
Topics: Animals; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug; Electric Stimulation; Female; Flumazenil; GABA Modulators; Midazolam; Motor Neurons; Muscle Contraction; Muscle, Smooth; Nociception; Pudendal Nerve; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Urinary Bladder | 2020 |
Shared structural mechanisms of general anaesthetics and benzodiazepines.
Topics: Allosteric Regulation; Anesthetics, General; Barbiturates; Benzodiazepines; Bicuculline; Binding Sites; Binding, Competitive; Cryoelectron Microscopy; Diazepam; Electrophysiology; Etomidate; Flumazenil; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Ligands; Models, Molecular; Molecular Conformation; Molecular Dynamics Simulation; Phenobarbital; Picrotoxin; Propofol; Receptors, GABA-A | 2020 |
Potential modulating effect of the Ascaris suum nicotinic acetylcholine receptor (nAChR) by compounds GSK575594A, diazepam and flumazenil discovered by structure-based virtual screening approach.
Topics: Acetylcholine; Animals; Anthelmintics; Ascaris suum; Binding Sites; Caenorhabditis elegans Proteins; Databases, Chemical; Diazepam; Flumazenil; Gene Expression; Helminth Proteins; High-Throughput Screening Assays; Humans; Ligands; Molecular Docking Simulation; Muscles; Piperazines; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Receptors, Nicotinic; Structural Homology, Protein; Tissue Culture Techniques; User-Computer Interface | 2021 |
How does α
Topics: Diazepam; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Histidine; Humans; Molecular Dynamics Simulation; Protein Conformation; Protein Subunits; Protons; Receptors, GABA-A | 2021 |
The biologically active compound of
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Ethanol; Flumazenil; Male; Maze Learning; Mice; Plant Extracts; Reflex, Righting; Withania | 2021 |
Bumetanide prevents diazepam-modified anxiety-like behavior in lipopolysaccharide-treated mice.
Topics: Animals; Anti-Anxiety Agents; Anti-Bacterial Agents; Anxiety; Behavior, Animal; Bicuculline; Bumetanide; Diazepam; Emotions; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Inflammation; Lipopolysaccharides; Male; Mice, Inbred ICR; Minocycline; Motor Activity; Sodium Potassium Chloride Symporter Inhibitors | 2021 |
Sedative-hypnotic, anxiolytic and possible side effects of Salvia limbata C. A. Mey. Extracts and the effects of phenological stage and altitude on the rosmarinic acid content.
Topics: Altitude; Animals; Antidotes; Cinnamates; Depsides; Diazepam; Flumazenil; Hypnotics and Sedatives; Male; Memory; Mice; Plant Components, Aerial; Plant Extracts; Rosmarinic Acid; Salvia; Toxicity Tests | 2022 |
High-Dose Benzodiazepines Positively Modulate GABA
Topics: Animals; Animals, Outbred Strains; Benzodiazepines; Clonazepam; Diazepam; Female; Flumazenil; GABA Antagonists; gamma-Aminobutyric Acid; Male; Mice; Midazolam; Receptors, GABA-A; Xenopus laevis | 2021 |
Anxiolytic-like Effect of Quercetin Possibly through GABA Receptor Interaction Pathway: In Vivo and In Silico Studies.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Maze Learning; Mice; Quercetin; Receptors, GABA; Receptors, GABA-A | 2022 |