flumazenil and clonidine

flumazenil has been researched along with clonidine in 23 studies

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19906 (26.09)18.7374
1990's6 (26.09)18.2507
2000's8 (34.78)29.6817
2010's3 (13.04)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Lombardo, F; Obach, RS; Waters, NJ1
Ahman, M; Holmén, AG; Wan, H1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Coop, CF; McNaughton, N; Scott, DJ1
Elsworth, JD; Ida, Y; Roth, RH1
Baldwin, HA; File, SE1
De Souza, RJ; Goodwin, GM; Green, AR1
Chopin, P; File, SE; Pellow, S2
Spealman, RD; Wettstein, JG1
Emmett-Oglesby, MW; Lal, H; Lewis, MW; Spencer, DG1
Chapouthier, G; Jacquot, F; Sara, S; Save, E; Venault, P1
Matsumoto, K; Nguyen, TT; Watanabe, H; Yamasaki, K1
Fujimoto, JM; Holmes, BB; Rady, JJ1
Castro, JL; Ramirez, A; Ricci, D; Taira, CA1
Choi, YM; Huh, IH; Jeong, JH; Lee, BC; Lee, SY; Min, YS; Sohn, UD1
Ozaki, S1

Reviews

2 review(s) available for flumazenil and clonidine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
[Drug dependence syndrome as a side effect of medical drug use].
    Nihon rinsho. Japanese journal of clinical medicine, 2007, Oct-28, Volume: 65 Suppl 8

    Topics: Central Nervous System Agents; Clonidine; Flumazenil; Humans; Naloxone; Psychotherapy, Group; Self-Help Groups; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors

2007

Other Studies

21 other study(ies) available for flumazenil and clonidine

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
    Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6

    Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry

2009
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
Pindolol antagonizes the effects on hippocampal rhythmical slow activity of clonidine, baclofen and 8-OH-DPAT, but not chlordiazepoxide and sodium amylobarbitone.
    Neuroscience, 1992, Volume: 46, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Amobarbital; Animals; Baclofen; Chlordiazepoxide; Clonidine; Electric Stimulation; Electrodes; Electroencephalography; Flumazenil; Hippocampus; Male; Pindolol; Rats; Rats, Inbred Strains; Tetrahydronaphthalenes

1992
Anxiogenic beta-carboline FG 7142 produces activation of noradrenergic neurons in specific brain regions of rats.
    Pharmacology, biochemistry, and behavior, 1991, Volume: 39, Issue:3

    Topics: Animals; Brain Chemistry; Carbolines; Clonidine; Flumazenil; Male; Methoxyhydroxyphenylglycol; Neurons; Norepinephrine; Rats; Rats, Inbred Strains; Sympathetic Nervous System

1991
Caffeine-induced anxiogenesis: the role of adenosine, benzodiazepine and noradrenergic receptors.
    Pharmacology, biochemistry, and behavior, 1989, Volume: 32, Issue:1

    Topics: 2-Chloroadenosine; Adenosine; Alprazolam; Anxiety; Caffeine; Chlordiazepoxide; Clonidine; Flumazenil; Motor Activity; Muscle Relaxants, Central; Norepinephrine; Propranolol; Receptors, Adrenergic; Receptors, GABA-A; Receptors, Purinergic; Social Behavior

1989
The pharmacology of the hypothermic response in mice to 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). A model of presynaptic 5-HT1 function.
    Neuropharmacology, 1985, Volume: 24, Issue:12

    Topics: 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Apomorphine; Benzodiazepinones; Body Temperature; Clonidine; Fenclonine; Flumazenil; Injections, Intraventricular; Male; Mice; Mice, Inbred C57BL; Naphthalenes; Tetrahydronaphthalenes; Time Factors

1985
The effects of yohimbine on exploratory and locomotor behaviour are attributable to its effects at noradrenaline and not at benzodiazepine receptors.
    Neuropharmacology, 1986, Volume: 25, Issue:1

    Topics: Adrenergic alpha-Antagonists; Animals; Benzodiazepinones; Chlordiazepoxide; Clonidine; Drug Interactions; Exploratory Behavior; Flumazenil; Male; Motor Activity; Rats; Receptors, GABA-A; Yohimbine

1986
Are the anxiogenic effects of yohimbine mediated by its action at benzodiazepine receptors?
    Neuroscience letters, 1985, Mar-22, Volume: 55, Issue:1

    Topics: Animals; Arousal; Benzodiazepinones; Brain; Chlordiazepoxide; Clonidine; Dose-Response Relationship, Drug; Flumazenil; Male; Rats; Receptors, Adrenergic, alpha; Receptors, GABA-A; Social Behavior; Social Environment; Yohimbine

1985
Distinctive behavioral effects of the pyrazoloquinoline CGS 8216 in squirrel monkeys.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 29, Issue:4

    Topics: Animals; Behavior, Animal; Benzodiazepines; Clonidine; Diazepam; Flumazenil; Male; Pyrazoles; Saimiri

1988
Bioassay of subjective effects associated with benzodiazepine withdrawal in animals: a novel direction in dependence research.
    NIDA research monograph, 1984, Volume: 49

    Topics: Animals; Benzodiazepinones; Biological Assay; Clonidine; Conditioning, Operant; Diazepam; Discrimination Learning; Flumazenil; Generalization, Stimulus; Humans; Male; Pentobarbital; Pentylenetetrazole; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders

1984
Anxiogenic-like effects of yohimbine and idazoxan in two behavioral situations in mice.
    Life sciences, 1993, Volume: 52, Issue:7

    Topics: Adrenergic alpha-Antagonists; Animals; Anxiety; Behavior, Animal; Choice Behavior; Clonidine; Conditioning, Classical; Conflict, Psychological; Dioxanes; Flumazenil; Idazoxan; Male; Mice; Yohimbine

1993
Involvement of supraspinal GABA receptors in majonoside-R2 suppression of clonidine-induced antinociception in mice.
    Life sciences, 1997, Volume: 61, Issue:4

    Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Clonidine; Flumazenil; GABA Antagonists; GABA Modulators; Ginsenosides; Idazoxan; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Male; Mice; Pain Measurement; Picrotoxin; Receptors, GABA-A; Saponins; Spinal Cord

1997
Supraspinal flumazenil inhibits the antianalgesic action of spinal dynorphin A (1-17).
    Pharmacology, biochemistry, and behavior, 1998, Volume: 60, Issue:1

    Topics: Analgesia; Analgesics; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Flumazenil; GABA Agonists; GABA-A Receptor Agonists; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone; Physostigmine

1998
Central benzodiazepine involvement in clonidine cardiovascular actions.
    Canadian journal of physiology and pharmacology, 1999, Volume: 77, Issue:11

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Atropine Derivatives; Blood Pressure; Carbolines; Cardiovascular Agents; Clonidine; Diazepam; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; Heart Rate; Infusions, Intravenous; Injections, Intraventricular; Male; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Receptors, GABA-A; Stereotaxic Techniques; Time Factors; Yohimbine

1999
The influences of extremely low frequency magnetic fields on clonidine-induced sleep in 2-day-old chicks.
    Journal of autonomic pharmacology, 2001, Volume: 21, Issue:4

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Animals, Newborn; Bicuculline; Brain Chemistry; Chickens; Chromatography, High Pressure Liquid; Clonidine; Dose-Response Relationship, Drug; Electrochemistry; Electromagnetic Fields; Flumazenil; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Norepinephrine; Sleep; Tyrosine

2001