flumazenil has been researched along with chlordiazepoxide in 153 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 78 (50.98) | 18.7374 |
| 1990's | 54 (35.29) | 18.2507 |
| 2000's | 14 (9.15) | 29.6817 |
| 2010's | 7 (4.58) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| McNamara, RK; Skelton, RW | 2 |
| Stackman, RW; Walsh, TJ | 1 |
| Ohno, M; Watanabe, S; Yamamoto, T | 1 |
| Coop, CF; McNaughton, N; Scott, DJ | 1 |
| Emmett-Oglesby, MW; Lal, H; Prather, PL; Rezazadeh, SM | 1 |
| Dudchenko, P; Paul, B; Sarter, M | 1 |
| Emmett-Oglesby, MW; Rowan, GA | 1 |
| Brain, PF; Kurishingal, H; Restall, CJ | 1 |
| Boone, MS; Emmett-Oglesby, MW; Pugh, SL | 1 |
| File, SE; Hitchcott, PK; Zharkovsky, A | 1 |
| De Boer, SF; Katz, JL; Valentino, RJ | 1 |
| Agmo, A; Fernández, H | 1 |
| Boulter, N; Gent, JP; Goodchild, CS; Serrao, JM | 1 |
| Belzung, C; Cabib, S; Fabiani, L; Puglisi-Allegra, S; Tolentino, P | 1 |
| Ichihara, K; Kameyama, T; Nabeshima, T; Tohyama, K | 2 |
| McNaughton, N; Zhu, XO | 1 |
| De Boer, SF; Slangen, JL; Van der Gugten, J | 2 |
| Leslie, JC; Shephard, RA; Toal, L | 1 |
| File, SE | 2 |
| Colpaert, FC | 1 |
| Gyr, K; Meier, R; Scholer, A | 1 |
| Chan, AW; Langan, MC; Leong, FW; Penetrante, ML; Schanley, DL | 3 |
| Carden, SE; Hofer, MA | 1 |
| Karim, KH; Najim, RA | 1 |
| Kameyama, T; Nabeshima, T; Tohyama, K | 1 |
| Schindler, CW; Thomas, DA; Weiss, SJ | 1 |
| Commissaris, RL; Ellis, DM; Fontana, DJ; McCloskey, TC | 1 |
| Pedemonte, M; Velluti, R | 1 |
| Haefely, W | 1 |
| Cook, JM; Hagen, T; Katz, JL; Suzuki, T; Takada, K | 1 |
| Baldwin, HA; File, SE | 4 |
| DiMicco, JA; Hingtgen, JN; Shekhar, A | 1 |
| Hamilton, MS; Shephard, RA | 1 |
| Emmett-Oglesby, MW; Mathis, DA | 1 |
| Hebert, MA; Henke, PG; Ray, A; Sullivan, RM; Trimper, JM | 1 |
| Blake, MJ; Dworkin, SI; Goeders, NE; Izenwasser, S | 1 |
| Goeders, NE; McAllister, KH; McNulty, MA; Mirkis, S | 1 |
| Cooper, SJ; Estall, LB | 1 |
| Green, S; Hodges, H | 1 |
| Mos, J; Olivier, B; van der Poel, AM | 1 |
| Farb, DH; Mierlak, D | 1 |
| Aldrich-Castanik, L; Chan, AW; Langan, MC; Leong, FW; Penetrante, ML; Schanley, DL | 1 |
| Aranko, K; File, SE | 1 |
| Lee, MA; Walczak, DD; Witkin, JM | 1 |
| Leidenheimer, NJ; Schechter, MD | 1 |
| Rodgers, RJ; Waters, AJ | 1 |
| Kubota, K; Matsuda, I; Matsuoka, Y; Sugaya, K; Terawaki, Y | 1 |
| File, SE; Pellow, S; Wilks, L | 1 |
| Barrett, JE; Brady, LS; Mansbach, RS; Stanley, JA; Witkin, JM | 1 |
| Chopin, P; File, SE; Pellow, S | 2 |
| Spealman, RD | 2 |
| Barrett, JE; Mansbach, RS; Skolnick, P; Weissman, BA; Witkin, JM | 1 |
| DiMicco, JA | 1 |
| File, SE; Pellow, S | 4 |
| Bold, JM; Gardner, CR; Walker, RJ | 1 |
| Barrett, JE; Brady, LS; Witkin, JM | 1 |
| Dingledine, R; King, GL; Knox, JJ | 1 |
| Fares, F; Gavish, M | 1 |
| Barber, DJ; Cooper, SJ; Jackson, A; Moores, WR | 1 |
| DiMicco, JA; Wible, JH; Zerbe, RL | 1 |
| De Vry, J; Slangen, JL | 2 |
| Beck, CH; Cooper, SJ | 1 |
| File, SE; Lister, RG | 1 |
| Berridge, KC; Schultz, CE; Treit, D | 1 |
| McLamb, RL; Tilson, HA; Walsh, TJ | 1 |
| Braestrup, C; Koob, GF; Thatcher Britton, K | 1 |
| Boisse, NR; Guarino, JJ; Kruger, HS; Periana, RM; Samoriski, GM | 1 |
| Randall, JI; Rodgers, RJ | 1 |
| Chan, AW | 1 |
| Britton, KT; Koob, GF; Lee, G | 1 |
| Boisse, N; Guarino, J; Samoriski, G | 1 |
| Sanger, DJ; Zivkovic, B | 1 |
| Criado, JR; Harland, RD; Holloway, FA; Holohean, AM; Hunter, GA; Michaelis, RC | 1 |
| Cole, SO | 1 |
| Cooper, SJ; Moores, WR | 1 |
| Cooper, SJ; Turkish, S | 1 |
| Little, HJ | 1 |
| Audi, EA; Graeff, FG | 1 |
| Fillenz, M; Fung, SC | 1 |
| Carney, JM; Nakamura, M | 1 |
| Mormède, P | 1 |
| Bichard, AR; Little, HJ | 1 |
| File, SE; Lister, RG; Nutt, DJ | 1 |
| Vellucci, SV; Webster, RA | 1 |
| File, SE; Tucker, JC | 1 |
| Cepeda, C; Comar, D; Crouzel, M; Guibert, B; Hantraye, P; Kaijima, M; Maziere, M; Naquet, R; Prenant, C; Sastre, J | 1 |
| Jeevanjee, F; Johnson, AM; Loudon, JM; Nicholass, JM | 1 |
| Blas, C; Ferron, A; Glowinski, J; Soubrie, P | 1 |
| Feldon, J; Lerner, T; Levin, D; Myslobodsky, M | 1 |
| Abernethy, DR; File, SE; Greenblatt, DJ; Lister, RG | 1 |
| File, SE; Herberg, LJ; Pellow, S | 1 |
| Schechter, MD | 1 |
| Clineschmidt, BV | 1 |
| Amano, M; Hasegawa, T; Kitaichi, K; Minami, Y; Nabeshima, T; Yamada, K | 1 |
| Sanders, SK; Shekhar, A | 1 |
| Czech, DA; Quock, RM | 1 |
| Emmanouil, DE; Johnson, CH; Quock, RM | 1 |
| Emmett-Oglesby, MW; English, SA; Lytle, DA | 1 |
| Bronson, ME | 1 |
| Emmett-Oglesby, MW; Hooper, ML; Lal, H; Lane, JD; Lytle, DA; Prather, PL; Rezazadeh, SM; Rowan, GA | 1 |
| Breese, GR; Criswell, HE | 1 |
| Curtis, BA; Czech, DA; Hodges, BL; Maillefer, RH; Quock, RM; Wetzel, PJ | 1 |
| Alastra, AJ; Cohen, C; Goldberg, SR; Marley, RJ; Sannerud, CA; Serdikoff, SL | 1 |
| Cartmell, SM; Mitchell, D | 1 |
| Emerich, DF; Stackman, RW; Taylor, LA; Walsh, TJ | 1 |
| Maier, SF; Short, KR | 1 |
| Brucato, FH; Stackman, RW; Swartzwelder, HS; Walsh, TJ | 1 |
| Nader, MA; Woolverton, WL | 1 |
| Lucki, I; Shumsky, JS | 1 |
| France, CP; Gerak, LR | 2 |
| Covey, DF; Ferrendelli, JA; Krause, JE; Rothman, SM; Tucker, JB; Weiss, DS; White, G; Williams, KL | 1 |
| Britton, KT; Kirby, D; Koob, G; Rivier, J; Southerland, S; Van Uden, E | 1 |
| Macey, DJ; Miczek, KA; Weerts, EM | 1 |
| Roach, JT; Sufka, KJ; Watson, GS | 1 |
| D'Amato, FR; Mandillo, S | 1 |
| Belzung, C; Crestani, F; Le Guisquet, AM | 1 |
| Britton, KT; Southerland, S | 1 |
| Dawson, GR; Ferris, P; Seward, E | 1 |
| Carter, AR; Cheo-Isaacs, CT; Crooke, JJ; DeLuca, S; DeVine, A; Dubinsky, B; Hochman, C; Jordan, AD; Reitz, AB; Rosenthal, DI; Shank, RP; Vaidya, AH | 1 |
| McNaughton, N; Woodnorth, MA | 1 |
| Chen, CF; Hung, WY; Liao, JF | 1 |
| Adeeko, MA; Maxa, JL; Ogu, CC; Swaner, TG | 1 |
| Jennings, CA; Siddiqi, M | 1 |
| Lamas, E; Pellón, R; Rodríguez, C; Ruíz, A | 1 |
| Evenden, J; Jonak, G; Ross, L; Zhou, J | 1 |
| France, CP; Gerak, LR; Yoon, SS; Zanettini, C | 1 |
| Cook, JM; Fischer, BD; Namjoshi, OA; Rowlett, JK; Teixeira, LP; van Linn, ML | 1 |
5 review(s) available for flumazenil and chlordiazepoxide
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Drug discrimination used to study drug withdrawal.
Topics: Animals; Chlordiazepoxide; Discrimination Learning; Flumazenil; Pentylenetetrazole; Substance Withdrawal Syndrome | 1991 |
Behavioural pharmacology of food, water and salt intake in relation to drug actions at benzodiazepine receptors.
Topics: Animals; Anti-Anxiety Agents; Appetite; Appetite Depressants; Benzodiazepines; Benzodiazepinones; Carbolines; Chlordiazepoxide; Chlorides; Choice Behavior; Diazepam; Drinking Behavior; Feeding Behavior; Flumazenil; Food Deprivation; Food Preferences; gamma-Aminobutyric Acid; Ion Channels; Midazolam; Picrotoxin; Punishment; Pyrazoles; Receptors, GABA-A; Satiation; Sodium Chloride; Species Specificity | 1985 |
Benzodiazepines and their antagonists: a pharmacoethological analysis with particular reference to effects on "aggression".
Topics: Aggression; Agonistic Behavior; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Chlordiazepoxide; Conflict, Psychological; Environment; Flumazenil; Humans; Midazolam; Predatory Behavior; Pyrazoles; Social Behavior; Species Specificity; Time Factors | 1985 |
[Neuroendocrine effects of benzodiazepines].
Topics: Adrenal Cortex Hormones; Anti-Anxiety Agents; Benzodiazepinones; Chlordiazepoxide; Clorazepate Dipotassium; Flumazenil; Growth Hormone; Humans; Hypothalamo-Hypophyseal System; Male; Pituitary-Adrenal System; Prolactin; Stress, Psychological; Sympathetic Nervous System | 1983 |
148 other study(ies) available for flumazenil and chlordiazepoxide
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Assessment of a cholinergic contribution to chlordiazepoxide-induced deficits of place learning in the Morris water maze.
Topics: Acetylcholine; Animals; Chlordiazepoxide; Drug Interactions; Flumazenil; Learning; Male; Memory; Physostigmine; Rats; Receptors, Cholinergic; Receptors, GABA-A; Scopolamine | 1992 |
Chlordiazepoxide-induced working memory impairments: site specificity and reversal by flumazenil (RO15-1788).
Topics: Amygdala; Animals; Brain; Brain Mapping; Chlordiazepoxide; Discrimination Learning; Dose-Response Relationship, Drug; Flumazenil; Male; Mental Recall; Orientation; Rats; Rats, Inbred Strains; Receptors, GABA-A; Retention, Psychology; Septum Pellucidum | 1992 |
Intrahippocampal injections of benzodiazepine and muscimol impair working memory but not reference memory of rats in the three-panel runway task.
Topics: Animals; Bicuculline; Chlordiazepoxide; Flumazenil; Hippocampus; Male; Memory; Muscimol; Rats; Rats, Wistar; Receptors, GABA-A | 1992 |
Pindolol antagonizes the effects on hippocampal rhythmical slow activity of clonidine, baclofen and 8-OH-DPAT, but not chlordiazepoxide and sodium amylobarbitone.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Amobarbital; Animals; Baclofen; Chlordiazepoxide; Clonidine; Electric Stimulation; Electrodes; Electroencephalography; Flumazenil; Hippocampus; Male; Pindolol; Rats; Rats, Inbred Strains; Tetrahydronaphthalenes | 1992 |
Evaluation of anxiolytic action of ondansetron in rats during withdrawal from chronic chlordiazepoxide.
Topics: Animals; Anti-Anxiety Agents; Chlordiazepoxide; Flumazenil; Imidazoles; Learning; Male; Ondansetron; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1992 |
Dissociation between the effects of benzodiazepine receptor agonists on behavioral vigilance and responsitivity.
Topics: Animals; Anti-Anxiety Agents; Arousal; Behavior, Animal; Carbolines; Chlordiazepoxide; Discrimination, Psychological; Dose-Response Relationship, Drug; Flumazenil; GABA-A Receptor Agonists; Male; Midazolam; Rats; Rats, Sprague-Dawley | 1992 |
Benzodiazepine-induced changes in biomembrane fluidity.
Topics: Chlordiazepoxide; Diazepam; Egg Yolk; Flumazenil; Lipid Bilayers; Liposomes; Membrane Fluidity; Models, Biological; Phosphatidylcholines; Spectrometry, Fluorescence | 1992 |
Tolerance, cross-tolerance and withdrawal in rats made dependent on diazepam.
Topics: Animals; Chlordiazepoxide; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Drug Tolerance; Flumazenil; Male; Midazolam; Pentylenetetrazole; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
Effects of nitrendipine, chlordiazepoxide, flumazenil and baclofen on the increased anxiety resulting from alcohol withdrawal.
Topics: Animals; Anxiety; Baclofen; Chlordiazepoxide; Diazepam; Ethanol; Flumazenil; Interpersonal Relations; Male; Nitrendipine; Rats; Substance Withdrawal Syndrome; Tremor | 1992 |
Common mechanisms underlying the proconflict effects of corticotropin-releasing factor, a benzodiazepine inverse agonist and electric foot-shock.
Topics: Animals; Behavior, Animal; Carbolines; Chlordiazepoxide; Convulsants; Corticotropin-Releasing Hormone; Electroshock; Flumazenil; Injections, Intraventricular; Male; Punishment; Rats; Rats, Inbred Strains | 1992 |
Benzodiazepine receptor ligands and sexual behavior in the male rat: the role of GABAergic mechanisms.
Topics: Animals; Bicuculline; Carbolines; Chlordiazepoxide; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Male; Motor Activity; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sexual Behavior, Animal | 1991 |
Spinally mediated antinociception following intrathecal chlordiazepoxide--further evidence for a benzodiazepine spinal analgesic effect.
Topics: Analgesia, Epidural; Animals; Catheters, Indwelling; Chlordiazepoxide; Dose-Response Relationship, Drug; Electric Stimulation; Fentanyl; Flumazenil; Injections, Spinal; Male; Naloxone; Nociceptors; Pain; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sensory Thresholds | 1991 |
LY 171555-induced hyperdefensiveness in the mouse does not implicate benzodiazepine receptors.
Topics: Aggression; Animals; Behavior, Animal; Carbolines; Chlordiazepoxide; Convulsants; Dopamine Agents; Dose-Response Relationship, Drug; Ergolines; Flumazenil; Mice; Mice, Inbred C57BL; Quinpirole; Receptors, GABA-A; Social Behavior | 1991 |
Involvement of GABAergic systems in benzodiazepine-induced impairment of passive avoidance learning in mice.
Topics: Animals; Anti-Anxiety Agents; Avoidance Learning; Bicuculline; Chlordiazepoxide; Drug Interactions; Flumazenil; GABA Antagonists; gamma-Aminobutyric Acid; Male; Memory; Mice; Mice, Inbred Strains; Muscimol; Picrotoxin | 1991 |
Effects of long-term administration of anxiolytics on reticular-elicited hippocampal rhythmical slow activity.
Topics: Animals; Anti-Anxiety Agents; Buspirone; Chlordiazepoxide; Electric Stimulation; Electroencephalography; Flumazenil; Hippocampus; Male; Rats; Rats, Inbred Strains; Reticular Formation | 1991 |
Effects of chlordiazepoxide, flumazenil and DMCM on plasma catecholamine and corticosterone concentrations in rats.
Topics: Animals; Carbolines; Catecholamines; Chlordiazepoxide; Corticosterone; Epinephrine; Flumazenil; Injections, Intraperitoneal; Male; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1991 |
Effects of chlordiazepoxide and putative anxiogenics on conditioned suppression in rats.
Topics: Amino Acids; Amino Acids, Neutral; Animals; Arousal; Avoidance Learning; Bicuculline; Chlordiazepoxide; Conditioning, Classical; Dose-Response Relationship, Drug; Electroshock; Fear; Flumazenil; Male; Picrotoxin; Rats; Rats, Inbred Strains | 1991 |
One-trial tolerance to the anxiolytic effects of chlordiazepoxide in the plus-maze.
Topics: Animals; Anti-Anxiety Agents; Chlordiazepoxide; Drug Tolerance; Flumazenil; Male; Rats | 1990 |
Amnesic trace locked into the benzodiazepine state of memory.
Topics: Amnesia; Animals; Anti-Anxiety Agents; Chlordiazepoxide; Conditioning, Operant; Conflict, Psychological; Dose-Response Relationship, Drug; Drug Tolerance; Flumazenil; Food; Food Deprivation; Male; Memory; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1990 |
Attenuation of benzodiazepine-induced passive avoidance deficit by post-training administration of muscimol: interaction with the cholinergic neuronal system.
Topics: Animals; Anti-Anxiety Agents; Avoidance Learning; Bicuculline; Chlordiazepoxide; Flumazenil; Male; Mice; Mice, Inbred Strains; Muscimol; Neurons; Parasympathetic Nervous System; Receptors, Cholinergic; Receptors, GABA-A; Scopolamine | 1990 |
Persisting benzodiazepine metabolites responsible for the reaction to the benzodiazepine antagonist flumazenil in patients with hepatic encephalopathy.
Topics: Benzodiazepines; Chlordiazepoxide; Chromatography, High Pressure Liquid; Flumazenil; Hepatic Encephalopathy; Humans; Middle Aged | 1991 |
The ability of chlordiazepoxide to maintain ethanol tolerance and dependence.
Topics: Animals; Body Temperature; Body Weight; Chlordiazepoxide; Diet; Drug Tolerance; Ethanol; Flumazenil; Male; Mice; Mice, Inbred C57BL; Sleep; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1991 |
Independence of benzodiazepine and opiate action in the suppression of isolation distress in rat pups.
Topics: Animals; Arousal; Chlordiazepoxide; Dose-Response Relationship, Drug; Flumazenil; Morphine; Motor Activity; Naltrexone; Rats; Rats, Inbred Strains; Social Isolation; Vocalization, Animal | 1990 |
Partial cross-dependence on ethanol in mice dependent on chlordiazepoxide.
Topics: Animals; Chlordiazepoxide; Ethanol; Flumazenil; Generalization, Stimulus; Male; Mice; Mice, Inbred C57BL; Motor Activity; Saccharin; Substance Withdrawal Syndrome; Substance-Related Disorders | 1990 |
Effect of CGS 9896 on stress-induced gastric ulcer in rat.
Topics: Animals; Benzodiazepines; Chlordiazepoxide; Cold Temperature; Drug Therapy, Combination; Flumazenil; Hyperglycemia; Male; Pyrazoles; Rats; Rats, Inbred Strains; Stomach Ulcer; Stress, Physiological | 1990 |
Effects of DM-9384, a pyrrolidone derivative, on alcohol- and chlordiazepoxide-induced amnesia in mice.
Topics: Amnesia; Animals; Avoidance Learning; Bicuculline; Central Nervous System Agents; Chlordiazepoxide; Drug Interactions; Ethanol; Flumazenil; Male; Mice; Pyrrolidinones; Retention, Psychology; Scopolamine | 1990 |
Brain benzodiazepine receptor-mediated effects on plasma catecholamine and corticosterone concentrations in rats.
Topics: Animals; Catecholamines; Chlordiazepoxide; Corticosterone; Dose-Response Relationship, Drug; Drug Interactions; Flumazenil; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stress, Physiological | 1990 |
Effects of chlordiazepoxide and flumazenil on preference for punished and unpunished response alternatives in rats.
Topics: Animals; Chlordiazepoxide; Choice Behavior; Conditioning, Operant; Dose-Response Relationship, Drug; Electroshock; Flumazenil; Male; Punishment; Rats; Reinforcement Schedule | 1990 |
Chronic anxiolytic treatment effects on conflict behavior in the rat.
Topics: Alprazolam; Animals; Behavior, Animal; Chlordiazepoxide; Conflict, Psychological; Dose-Response Relationship, Drug; Female; Flumazenil; Panic; Phenobarbital; Prohibitins; Rats; Rats, Inbred Strains | 1990 |
Differential effects of benzodiazepines on cochlear and auditory nerve responses.
Topics: Action Potentials; Animals; Chlordiazepoxide; Cochlear Microphonic Potentials; Evoked Potentials, Auditory; Flumazenil; Guinea Pigs; Midazolam; Pentobarbital; Vestibulocochlear Nerve | 1986 |
Partial agonists of the benzodiazepine receptor: from animal data to results in patients.
Topics: Affinity Labels; Allosteric Site; Animals; Azides; Benzodiazepines; Benzodiazepinones; Chlordiazepoxide; Chlorides; Clonazepam; Diazepam; Drug Interactions; Ethanol; Flumazenil; Flurazepam; Humans; Ion Channels; Ligands; Models, Neurological; Neurons; Receptors, GABA-A | 1988 |
Behavioral effects of benzodiazepine antagonists in chlordiazepoxide tolerant and non-tolerant rats.
Topics: Animals; Behavior, Animal; Benzodiazepines; Carbolines; Chlordiazepoxide; Dose-Response Relationship, Drug; Drug Tolerance; Flumazenil; Male; Pyrazoles; Rats; Rats, Inbred F344 | 1989 |
Flumazenil prevents the development of chlordiazepoxide withdrawal in rats tested in the social interaction test of anxiety.
Topics: Animals; Anxiety; Chlordiazepoxide; Flumazenil; Interpersonal Relations; Male; Motor Activity; Rats; Substance Withdrawal Syndrome | 1989 |
Anxiogenic effects of noreleagnine, a water soluble beta-carboline in rats.
Topics: Animals; Anxiety; Carbolines; Chlordiazepoxide; Conflict, Psychological; Flumazenil; Male; Rats; Rats, Inbred Strains; Reinforcement, Psychology | 1989 |
Chlordiazepoxide and valproate enhancement of saline drinking by nondeprived rats: effects of bicuculline, picrotoxin and Ro15-1788.
Topics: Animals; Bicuculline; Chlordiazepoxide; Dose-Response Relationship, Drug; Drinking Behavior; Drug Combinations; Drug Interactions; Flumazenil; Male; Picrotoxin; Rats; Rats, Inbred Strains; Sodium Chloride; Valproic Acid | 1989 |
A liquid diet model of chlordiazepoxide dependence in mice.
Topics: Animals; Chlordiazepoxide; Diet; Disease Models, Animal; Drinking; Flumazenil; Male; Mice; Mice, Inbred C57BL; Motor Activity; Substance Withdrawal Syndrome; Substance-Related Disorders | 1989 |
Withdrawal from benzodiazepine dependence as a discriminative stimulus.
Topics: Animals; Chlordiazepoxide; Cocaine; Discrimination Learning; Flumazenil; Pentylenetetrazole; Rats; Substance Withdrawal Syndrome | 1989 |
The GABA/benzodiazepine receptor complex in the central amygdalar nucleus and stress ulcers in rats.
Topics: Amygdala; Animals; Arousal; Chlordiazepoxide; Dose-Response Relationship, Drug; Flumazenil; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stomach Ulcer; Stress, Psychological | 1989 |
Caffeine-induced anxiogenesis: the role of adenosine, benzodiazepine and noradrenergic receptors.
Topics: 2-Chloroadenosine; Adenosine; Alprazolam; Anxiety; Caffeine; Chlordiazepoxide; Clonidine; Flumazenil; Motor Activity; Muscle Relaxants, Central; Norepinephrine; Propranolol; Receptors, Adrenergic; Receptors, GABA-A; Receptors, Purinergic; Social Behavior | 1989 |
Punishment modifies the effects of chlordiazepoxide and benzodiazepine receptors.
Topics: Animals; Behavior, Animal; Chlordiazepoxide; Flumazenil; Male; Punishment; Rats; Rats, Inbred F344; Receptors, GABA-A | 1989 |
Chlordiazepoxide alters intravenous cocaine self-administration in rats.
Topics: Animals; Behavior, Animal; Chlordiazepoxide; Cocaine; Dose-Response Relationship, Drug; Flumazenil; Injections, Intravenous; Male; Rats; Rats, Inbred F344; Receptors, GABA-A; Reinforcement, Psychology; Self Administration | 1989 |
Are the effects of benzodiazepines on discrimination and punishment dissociable?
Topics: Amygdala; Animals; Behavior, Animal; Benzodiazepines; Carbolines; Chlordiazepoxide; Discrimination, Psychological; Ethanolamines; Flumazenil; gamma-Aminobutyric Acid; Midazolam; Punishment; Pyrazoles; Rats; Receptors, GABA-A | 1987 |
Modulatory actions of benzodiazepine receptor ligands on agonistic behaviour.
Topics: Aggression; Agonistic Behavior; Animals; Behavior, Animal; Carbolines; Chlordiazepoxide; Female; Flumazenil; Maternal Behavior; Mice; Predatory Behavior; Rats; Receptors, GABA-A | 1987 |
Modulation of neurotransmitter receptor desensitization: chlordiazepoxide stimulates fading of the GABA response.
Topics: Animals; Chick Embryo; Chlordiazepoxide; Flumazenil; gamma-Aminobutyric Acid; Neurons; Receptors, GABA-A; Spinal Cord | 1988 |
Differential effects of Ro15-1788 in actions of chlordiazepoxide and ethanol.
Topics: Animals; Behavior, Animal; Chlordiazepoxide; Drug Interactions; Ethanol; Flumazenil; Hypothermia; Male; Mice; Mice, Inbred C57BL; Receptors, GABA-A | 1988 |
Reversal of increased anxiety during benzodiazepine withdrawal: evidence for an anxiogenic endogenous ligand for the benzodiazepine receptor.
Topics: Animals; Anxiety; Behavior, Animal; Chlordiazepoxide; Flumazenil; Male; Rats; Receptors, GABA-A; Substance Withdrawal Syndrome | 1988 |
Sodium valproate decreases exploratory behaviour in mice: development of tolerance and cross-tolerance with chlordiazepoxide.
Topics: Animals; Chlordiazepoxide; Drug Tolerance; Exploratory Behavior; Flumazenil; gamma-Aminobutyric Acid; Male; Mice; Motor Activity; Receptors, GABA-A; Valproic Acid | 1988 |
Anxiolytic properties of amygdaloid kindling unrelated to benzodiazepine receptors.
Topics: Amygdala; Animals; Anxiety; Cerebral Cortex; Chlordiazepoxide; Electric Stimulation; Flumazenil; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1988 |
Discriminative stimulus properties of CGS 9896: interactions within the GABA/benzodiazepine receptor complex.
Topics: Animals; Carbolines; Chlordiazepoxide; Discrimination, Psychological; Dose-Response Relationship, Drug; Flumazenil; gamma-Aminobutyric Acid; Male; Pentobarbital; Pentylenetetrazole; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1988 |
Reversal of antinociceptive effect of cholecystokinin by benzodiazepines and a benzodiazepine antagonist, Ro 15-1788.
Topics: Analgesics; Animals; Anti-Anxiety Agents; Benzodiazepinones; Chlordiazepoxide; Cholecystokinin; Diazepam; Flumazenil; Flurazepam; Male; Mice; Morphine; Naloxone; Pain; Sensory Thresholds; Time Factors | 1985 |
The sedative effects of CL 218,872, like those of chlordiazepoxide, are reversed by benzodiazepine antagonists.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepinones; Chlordiazepoxide; Convulsants; Flumazenil; Hypnotics and Sedatives; Male; Mice; Motor Activity; Pyrazoles; Pyridazines | 1985 |
Behavioral studies with anxiolytic drugs. II. Interactions of zopiclone with ethyl-beta-carboline-3-carboxylate and Ro 15-1788 in squirrel monkeys.
Topics: Animals; Anti-Anxiety Agents; Azabicyclo Compounds; Behavior, Animal; Benzodiazepinones; Carbolines; Chlordiazepoxide; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Female; Flumazenil; Food; Male; Piperazines; Punishment; Receptors, GABA-A; Saimiri | 1986 |
The effects of yohimbine on exploratory and locomotor behaviour are attributable to its effects at noradrenaline and not at benzodiazepine receptors.
Topics: Adrenergic alpha-Antagonists; Animals; Benzodiazepinones; Chlordiazepoxide; Clonidine; Drug Interactions; Exploratory Behavior; Flumazenil; Male; Motor Activity; Rats; Receptors, GABA-A; Yohimbine | 1986 |
Disruption of schedule-controlled behavior by Ro 15-1788 one day after acute treatment with benzodiazepines.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Chlordiazepoxide; Conditioning, Operant; Convulsants; Diazepam; Flumazenil; Male; Nordazepam; Reinforcement Schedule; Saimiri | 1986 |
Behavioral studies with anxiolytic drugs. III. Antipunishment actions of buspirone in the pigeon do not involve benzodiazepine receptor mechanisms.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Buspirone; Chlordiazepoxide; Columbidae; Diazepam; Flumazenil; Flunitrazepam; Punishment; Pyrimidines; Receptors, GABA-A | 1986 |
Flumazenil: a possible treatment for benzodiazepine withdrawal anxiety.
Topics: Animals; Anxiety; Benzodiazepines; Chlordiazepoxide; Flumazenil; Rats; Substance Withdrawal Syndrome | 1987 |
Evidence for control of cardiac vagal tone by benzodiazepine receptors.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Atropine; Chlordiazepoxide; Flumazenil; Heart; Heart Rate; Male; Midazolam; Rats; Rats, Inbred Strains; Receptors, GABA-A; Vagus Nerve | 1987 |
Discriminative-stimulus effects of midazolam in squirrel monkeys: comparison with other drugs and antagonism by Ro 15-1788.
Topics: Animals; Azabicyclo Compounds; Barbital; Benzodiazepines; Benzodiazepinones; Buspirone; Caffeine; Chlordiazepoxide; Cinanserin; Clozapine; Conditioning, Operant; Cyproheptadine; Diazepam; Diphenhydramine; Discrimination Learning; Electroshock; Flumazenil; Male; Midazolam; Muscimol; Nordazepam; Pentobarbital; Piperazines; Pyridazines; Pyrimidines; Saimiri; Tripelennamine | 1985 |
The anxiogenic action of RO 5-4864 in the social interaction test: effect of chlordiazepoxide, RO 15-1788 and CGS 8216.
Topics: Animals; Anxiety; Benzodiazepinones; Chlordiazepoxide; Convulsants; Drug Interactions; Flumazenil; Humans; Male; Motor Activity; Pyrazoles; Rats; Receptors, GABA-A; Social Behavior | 1985 |
Central effects of nicotinamide and inosine which are not mediated through benzodiazepine receptors.
Topics: Action Potentials; Animals; Benzodiazepinones; Bicuculline; Binding, Competitive; Brain; Chlordiazepoxide; Convulsants; Female; Flumazenil; Flunitrazepam; In Vitro Techniques; Inosine; Male; Membranes; Niacinamide; Purkinje Cells; Rats; Rats, Inbred Strains; Receptors, GABA-A; Social Behavior | 1985 |
Are the anxiogenic effects of yohimbine mediated by its action at benzodiazepine receptors?
Topics: Animals; Arousal; Benzodiazepinones; Brain; Chlordiazepoxide; Clonidine; Dose-Response Relationship, Drug; Flumazenil; Male; Rats; Receptors, Adrenergic, alpha; Receptors, GABA-A; Social Behavior; Social Environment; Yohimbine | 1985 |
Behavioral studies with anxiolytic drugs. I. Interactions of the benzodiazepine antagonist Ro 15-1788 with chlordiazepoxide, pentobarbital and ethanol.
Topics: Animals; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Chlordiazepoxide; Dose-Response Relationship, Drug; Electroshock; Ethanol; Female; Flumazenil; Food; Male; Pentobarbital; Punishment; Receptors, GABA-A; Reinforcement, Psychology; Saimiri | 1985 |
Reduction of inhibition by a benzodiazepine antagonist, Ro15-1788, in the rat hippocampal slice.
Topics: Animals; Benzodiazepinones; Chlordiazepoxide; Diazepam; Electric Conductivity; Evoked Potentials; Flumazenil; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Neural Inhibition; Rats; Synaptic Transmission | 1985 |
Solubilization of peripheral benzodiazepine-binding sites from rat kidney.
Topics: Animals; Benzodiazepinones; Binding, Competitive; Carbolines; Chlordiazepoxide; Clonazepam; Diazepam; Digitonin; Flumazenil; Flurazepam; Guanidine; Guanidines; Hot Temperature; Isoquinolines; Kidney; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Solubility; Time Factors; Urea | 1985 |
Effects of tifluadom on food consumption compared with chlordiazepoxide and kappa agonists in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzodiazepinones; Benzomorphans; Chlordiazepoxide; Convulsants; Cyclazocine; Drug Interactions; Eating; Ethylketocyclazocine; Flumazenil; Male; Naloxone; Pyrazoles; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1985 |
Benzodiazepine receptors modulate circulating plasma vasopressin concentration.
Topics: Animals; Arginine Vasopressin; Benzodiazepinones; Blood Pressure; Chlordiazepoxide; Flumazenil; Male; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1985 |
Effects of chlordiazepoxide training dose on the mixed agonist-antagonist properties of benzodiazepine receptor antagonist Ro 15-1788, in a drug discrimination procedure.
Topics: Animals; Benzodiazepinones; Brain; Chlordiazepoxide; Cues; Discrimination Learning; Drug Interactions; Flumazenil; Generalization, Stimulus; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1986 |
Differential interactions between chlordiazepoxide, pentobarbital and benzodiazepine antagonists Ro 15-1788 and CGS 8216 in a drug discrimination procedure.
Topics: Animals; Benzodiazepinones; Chlordiazepoxide; Conditioning, Operant; Cues; Discrimination Learning; Drug Interactions; Flumazenil; Generalization, Stimulus; Male; Pentobarbital; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1986 |
beta-Carboline FG 7142-reduced aggression in male rats: reversed by the benzodiazepine receptor antagonist, Ro15-1788.
Topics: Aggression; Analysis of Variance; Animals; Avoidance Learning; Benzodiazepinones; Carbolines; Chlordiazepoxide; Flumazenil; Male; Motor Activity; Rats; Receptors, GABA-A | 1986 |
The effect of chlordiazepoxide on the habituation of exploration: interactions with the benzodiazepine antagonist RO 15-1788.
Topics: Animals; Chlordiazepoxide; Drug Interactions; Exploratory Behavior; Flumazenil; Habituation, Psychophysiologic; Male; Motor Activity; Rats; Receptors, GABA-A | 1987 |
The direct enhancement of positive palatability by chlordiazepoxide is antagonized by Ro 15-1788 and CGS 8216.
Topics: Animals; Chlordiazepoxide; Consummatory Behavior; Flumazenil; Food Preferences; Male; Pyrazoles; Rats; Receptors, GABA-A; Solutions; Taste | 1987 |
A comparison of the effects of RO15,1788 and chlordiazepoxide on hot-plate latencies, acoustic startle, and locomotor activity.
Topics: Acoustic Stimulation; Animals; Benzodiazepinones; Chlordiazepoxide; Flumazenil; Male; Motor Activity; Pain; Rats; Rats, Inbred F344; Reaction Time; Reflex, Startle | 1986 |
The effects of FG 7142 and RO 15-1788 on the release of punished responding produced by chlordiazepoxide and ethanol in the rat.
Topics: Animals; Carbolines; Chlordiazepoxide; Conditioning, Operant; Conflict, Psychological; Electroshock; Ethanol; Flumazenil; Male; Punishment; Rats; Rats, Inbred Strains | 1986 |
Pharmacologic characterization of acute chlordiazepoxide dependence in the rat.
Topics: Animals; Behavior, Animal; Chlordiazepoxide; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Flumazenil; Male; Pyrazoles; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1986 |
Benzodiazepine ligands, nociception and 'defeat' analgesia in male mice.
Topics: Analgesia; Animals; Appetite Depressants; Benzodiazepines; Carbolines; Chlordiazepoxide; Diazepam; Flumazenil; Male; Mice; Mice, Inbred DBA; Nociceptors; Pyrazoles | 1987 |
Ethanol and chlordiazepoxide cross-dependence.
Topics: Alcoholism; Animals; Chlordiazepoxide; Flumazenil; Male; Mice; Mice, Inbred C57BL; Substance Withdrawal Syndrome; Substance-Related Disorders | 1987 |
Corticotropin releasing factor and amphetamine exaggerate partial agonist properties of benzodiazepine antagonist Ro 15-1788 in the conflict test.
Topics: Amphetamine; Animals; Behavior, Animal; Carbolines; Chlordiazepoxide; Conflict, Psychological; Corticotropin-Releasing Hormone; Drug Interactions; Flumazenil; Male; Motor Activity; Rats; Rats, Inbred Strains | 1988 |
Flurothyl seizure thresholds associated with acute and chronic chlordiazepoxide dependence and withdrawal.
Topics: Animals; Chlordiazepoxide; Dose-Response Relationship, Drug; Flumazenil; Flurothyl; Male; Rats; Rats, Inbred Strains; Seizures | 1988 |
Further behavioural evidence for the selective sedative action of zolpidem.
Topics: Animals; Chlordiazepoxide; Conditioning, Operant; Eating; Exploratory Behavior; Flumazenil; Hypnotics and Sedatives; Male; Punishment; Pyridines; Rats; Rats, Inbred Strains; Zolpidem | 1988 |
The chlordiazepoxide/pentylenetetrazol discrimination: characterization of drug interactions and homeostatic responses to drug challenges.
Topics: Animals; Chlordiazepoxide; Discrimination, Psychological; Drug Interactions; Flumazenil; Generalization, Stimulus; Homeostasis; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Time Factors | 1988 |
Dose-dependent reversal of chlordiazepoxide-induced discrimination impairment by Ro 15-1788.
Topics: Animals; Chlordiazepoxide; Discrimination, Psychological; Dose-Response Relationship, Drug; Extinction, Psychological; Flumazenil; Male; Rats; Rats, Inbred Strains | 1988 |
Chlordiazepoxide-induced hyperphagia in non-food-deprived rats: effects of Ro15-1788, CGS 8216 and ZK 93 426.
Topics: Animals; Benzodiazepinones; Carbolines; Chlordiazepoxide; Convulsants; Dose-Response Relationship, Drug; Drug Interactions; Eating; Flumazenil; Indoles; Male; Pyrazoles; Rats | 1985 |
Chlordiazepoxide enhances the anxiogenic action of CGS 8216 in the social interaction test: evidence for benzodiazepine withdrawal?
Topics: Animals; Anxiety; Benzodiazepinones; Carbolines; Chlordiazepoxide; Flumazenil; Humans; Male; Pyrazoles; Rats; Social Behavior; Species Specificity; Substance Withdrawal Syndrome | 1985 |
Enhancement of saline consumption by chlordiazepoxide in thirsty rats: antagonism by Ro15-1788.
Topics: Animals; Benzodiazepinones; Chlordiazepoxide; Drinking Behavior; Drug Interactions; Flumazenil; Male; Rats; Receptors, Cell Surface; Receptors, GABA-A; Sodium Chloride; Thirst | 1984 |
The effects of benzodiazepine agonists, inverse agonists and Ro 15-1788 on the responses of the superior cervical ganglion to GABA in vitro.
Topics: Animals; Barbiturates; Benzodiazepinones; Bicuculline; Carbolines; Chlordiazepoxide; Flumazenil; Flurazepam; gamma-Aminobutyric Acid; Ganglia, Sympathetic; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1984 |
Benzodiazepine receptors in the periaqueductal grey mediate anti-aversive drug action.
Topics: Animals; Avoidance Learning; Benzodiazepines; Benzodiazepinones; Chlordiazepoxide; Electric Stimulation; Electrodes, Implanted; Escape Reaction; Flumazenil; Male; Midazolam; Periaqueductal Gray; Rats; Rats, Inbred Strains; Receptors, GABA-A; Reinforcement, Psychology | 1984 |
Multiple effects of drugs acting on benzodiazepine receptors.
Topics: Animals; Benzodiazepinones; Calcium; Carbolines; Chlordiazepoxide; Drug Interactions; Flumazenil; gamma-Aminobutyric Acid; Male; Norepinephrine; Potassium; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1984 |
Antagonism by CGS 8216 and Ro 15-1788, benzodiazepines antagonists, of the action of chlordiazepoxide on a timing behavior in rats.
Topics: Animals; Benzodiazepinones; Chlordiazepoxide; Conditioning, Psychological; Flumazenil; Male; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Reinforcement Schedule | 1984 |
Differential effects of the benzodiazepine antagonist Ro 15-1788 after "general anaesthetic" doses of benzodiazepines in mice.
Topics: Anesthesia, General; Anesthetics; Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Chlordiazepoxide; Convulsants; Diazepam; Flumazenil; Flurazepam; Male; Mice; Mice, Inbred Strains; Midazolam; Reflex | 1984 |
Intrinsic actions of benzodiazepine antagonists.
Topics: Animals; Benzodiazepinones; Brain; Carbolines; Chlordiazepoxide; Dose-Response Relationship, Drug; Exploratory Behavior; Flumazenil; Indoles; Male; Motor Activity; Muridae; Receptors, Drug; Receptors, GABA-A | 1982 |
Antagonism of the anticonflict effects of chlordiazepoxide by beta-carboline carboxylic acid ethyl ester, Ro 15-1788 and ACTH(4--10).
Topics: Adrenocorticotropic Hormone; Animals; Arousal; Benzodiazepinones; Carbolines; Chlordiazepoxide; Conditioning, Operant; Conflict, Psychological; Fear; Flumazenil; Indoles; Male; Muridae; Peptide Fragments; Receptors, Cell Surface; Receptors, GABA-A; Reinforcement Schedule | 1982 |
Chronic neonatal treatment with CGS 8216: effects on the behaviour of adolescent rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Benzodiazepinones; Brain; Chlordiazepoxide; Dose-Response Relationship, Drug; Exploratory Behavior; Female; Flumazenil; Motor Activity; Pregnancy; Pyrazoles; Rats; Receptors, Cell Surface; Receptors, GABA-A; Seizures; Social Behavior | 1984 |
[In vivo study of benzodiazepine receptors using positron emission tomography].
Topics: Animals; Benzodiazepinones; Binding, Competitive; Brain; Chlordiazepoxide; Flumazenil; Flunitrazepam; Kinetics; Lorazepam; Male; Papio; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Neurotransmitter; Stereoisomerism | 1983 |
Enhancement of [3H]flunitrazepam binding by mianserin, in vivo.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Chlordiazepoxide; Convulsants; Dibenzazepines; Drinking Behavior; Flumazenil; Flunitrazepam; Kinetics; Male; Mianserin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1984 |
Chlordiazepoxide reduces in vivo serotonin release in the basal ganglia of encéphale isolé but not anesthetized cats: evidence for a dorsal raphe site of action.
Topics: Anesthesia; Animals; Basal Ganglia; Benzodiazepinones; Brain Stem; Cats; Chlordiazepoxide; Decerebrate State; Female; Flumazenil; gamma-Aminobutyric Acid; Halothane; Hippocampus; Injections, Intraperitoneal; Male; Raphe Nuclei; Serotonin | 1983 |
A behavioral examination of convulsant benzodiazepine and GABA antagonist, Ro 5-3663, and benzodiazepine-receptor antagonist Ro 15-1788.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Chlordiazepoxide; Conflict, Psychological; Convulsants; Drug Interactions; Flumazenil; Male; Punishment; Rats; Reward | 1983 |
Pharmacokinetic studies on Ro 15-1788, a benzodiazepine receptor ligand, in the brain of the rat.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Brain; Brain Chemistry; Chlordiazepoxide; Flumazenil; Half-Life; Kinetics; Male; Rats | 1984 |
Intracranial self-stimulation distinguishes between two benzodiazepine antagonists.
Topics: Animals; Benzodiazepinones; Chlordiazepoxide; Drug Combinations; Flumazenil; Hypothalamic Area, Lateral; Male; Pyrazoles; Rats; Self Stimulation | 1984 |
Behavioural effects of pentylenetetrazole reversed by chlordiazepoxide and enhanced by RO 15-1788.
Topics: Animals; Behavior, Animal; Benzodiazepinones; Chlordiazepoxide; Flumazenil; Male; Motor Activity; Pentylenetetrazole; Rats; Time Factors | 1984 |
The anxiogenic action of Ro 15-1788 is reversed by chronic, but not by acute, treatment with chlordiazepoxide.
Topics: Animals; Anxiety; Benzodiazepinones; Chlordiazepoxide; Flumazenil; Humans; Male; Motor Activity; Rats; Social Behavior; Time Factors | 1984 |
Specific antagonism of the behavioral effects of chlordiazepoxide and pentobarbital in the rat.
Topics: Animals; Bemegride; Benzodiazepinones; Chlordiazepoxide; Cues; Discrimination Learning; Dose-Response Relationship, Drug; Flumazenil; Male; Pentobarbital; Rats; Rats, Inbred Strains; Transfer, Psychology | 1984 |
The anxiogenic action of FG 7142 in the social interaction test is reversed by chlordiazepoxide and Ro 15-1788 but not by CGS 8216.
Topics: Animals; Anxiety; Benzodiazepinones; Carbolines; Chlordiazepoxide; Convulsants; Flumazenil; Humans; Indoles; Male; Motor Activity; Pyrazoles; Rats; Social Behavior | 1984 |
Effect of the benzodiazepine receptor antagonist Ro 15-1788 on the anticonvulsant and anticonflict actions of MK-801.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzodiazepinones; Bicuculline; Chlordiazepoxide; Clonazepam; Conflict, Psychological; Dibenzocycloheptenes; Dizocilpine Maleate; Drug Interactions; Female; Flumazenil; Mice; Phenobarbital; Rats; Rats, Inbred Strains | 1982 |
The attenuation of suppression of motility by triazolam in the conditioned fear stress task is exacerbated by ethanol in mice.
Topics: Animals; Chlordiazepoxide; Conditioning, Classical; Drug Synergism; Electric Stimulation; Ethanol; Fear; Flumazenil; Learning; Male; Mice; Motor Activity; Pain Threshold; Receptors, GABA-A; Stress, Psychological; Triazolam | 1995 |
Anxiolytic effects of chlordiazepoxide blocked by injection of GABAA and benzodiazepine receptor antagonists in the region of the anterior basolateral amygdala of rats.
Topics: Amygdala; Animals; Arousal; Bicuculline; Brain Mapping; Chlordiazepoxide; Flumazenil; GABA-A Receptor Antagonists; Male; Rats; Rats, Wistar; Receptors, GABA-A; Social Behavior | 1995 |
Nitrous oxide induces an anxiolytic-like effect in the conditioned defensive burying paradigm, which can be reversed with a benzodiazepine receptor blocker.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Chlordiazepoxide; Conditioning, Operant; Dose-Response Relationship, Drug; Flumazenil; GABA-A Receptor Antagonists; Male; Motor Activity; Nitrous Oxide; Rats | 1993 |
Nitrous oxide anxiolytic effect in mice in the elevated plus maze: mediation by benzodiazepine receptors.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Chlordiazepoxide; Dose-Response Relationship, Drug; Drug Tolerance; Exploratory Behavior; Flumazenil; Male; Mice; Mice, Inbred ICR; Nitrous Oxide; Receptors, GABA-A | 1994 |
Abecarnil used to treat benzodiazepine withdrawal.
Topics: Animals; Anti-Anxiety Agents; Carbolines; Chlordiazepoxide; Cues; Discrimination Learning; Flumazenil; Male; Rats; Substance Withdrawal Syndrome | 1993 |
Chlordiazepoxide, but not bretazenil, produces acute dependence, as evidenced by disruptions in schedule-controlled behavior.
Topics: Animals; Benzodiazepinones; Chlordiazepoxide; Conditioning, Operant; Flumazenil; Male; Rats; Reinforcement Schedule; Substance Withdrawal Syndrome; Substance-Related Disorders | 1994 |
Conflicting evidence regarding the efficacy of ondansetron in benzodiazepine withdrawal.
Topics: Animals; Anti-Anxiety Agents; Chlordiazepoxide; Conditioning, Psychological; Discrimination Learning; Flumazenil; Male; Ondansetron; Pentylenetetrazole; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1993 |
Effects of intracranial infusions of chlordiazepoxide on spatial learning in the Morris water maze. II. Neuropharmacological specificity.
Topics: Animals; Brain; Chlordiazepoxide; Cholinesterase Inhibitors; Cues; Dose-Response Relationship, Drug; Flumazenil; Injections; Learning; Male; Parasympathetic Nervous System; Parasympatholytics; Rats; Receptors, GABA-A; Space Perception; Tacrine | 1993 |
Similar effects of ethanol and flumazenil on acquisition of a shuttle-box avoidance response during withdrawal from chronic ethanol treatment.
Topics: Animals; Avoidance Learning; Azides; Benzodiazepines; Chlordiazepoxide; Conflict, Psychological; Dose-Response Relationship, Drug; Ethanol; Flumazenil; Male; Postural Balance; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1993 |
Benzodiazepine receptor-mediated behavioral effects of nitrous oxide in the rat social interaction test.
Topics: Animals; Anxiety; Chlordiazepoxide; Dose-Response Relationship, Drug; Flumazenil; GABA-A Receptor Antagonists; Interpersonal Relations; Male; Nitrous Oxide; Rats | 1993 |
Tolerance to the behavioral effects of chlordiazepoxide: pharmacological and biochemical selectivity.
Topics: Amphetamine; Animals; Behavior, Animal; Caffeine; Carbolines; Chlordiazepoxide; Chlorides; Chlorine; Dose-Response Relationship, Drug; Drug Tolerance; Flumazenil; gamma-Aminobutyric Acid; Male; Midazolam; Morphine; Pentobarbital; Radioisotopes; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sensitivity and Specificity; Stimulation, Chemical | 1993 |
Attenuation of reperfusion hyperalgesia in the rat by systemic administration of benzodiazepines.
Topics: Animals; Behavior, Animal; Benzodiazepines; Chlordiazepoxide; Depression, Chemical; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Hyperalgesia; Ischemia; Male; Motor Activity; Naloxone; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Reperfusion Injury; Tail | 1993 |
Intraseptal injection of GABA and benzodiazepine receptor ligands alters high-affinity choline transport in the hippocampus.
Topics: Acetylcholinesterase; Animals; Baclofen; Brain; Carbolines; Chlordiazepoxide; Choline; Convulsants; Flumazenil; gamma-Aminobutyric Acid; Hippocampus; Injections; Male; Muscimol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Synaptosomes | 1993 |
Stressor controllability, social interaction, and benzodiazepine systems.
Topics: Animals; Anxiety; Carbolines; Chlordiazepoxide; Dose-Response Relationship, Drug; Electroshock; Flumazenil; Interpersonal Relations; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Stress, Psychological | 1993 |
Medial septal benzodiazepine receptors modulate hippocampal evoked responses and long-term potentiation.
Topics: Animals; Anti-Anxiety Agents; Chlordiazepoxide; Cholinergic Fibers; Cognition; Dentate Gyrus; Evoked Potentials; Female; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; Hippocampus; Long-Term Potentiation; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Septal Nuclei | 1996 |
Effects of several benzodiazepines, alone and in combination with flumazenil, in rhesus monkeys trained to discriminate pentobarbital from saline.
Topics: Animals; Anti-Anxiety Agents; Chlordiazepoxide; Conditioning, Operant; Diazepam; Discrimination Learning; Drug Interactions; Flumazenil; GABA-A Receptor Antagonists; Macaca mulatta | 1995 |
Differential tolerance to the effects of chlordiazepoxide on unpunished and punished operant responding following chronic treatment.
Topics: Animals; Behavior, Animal; Chlordiazepoxide; Conditioning, Operant; Cricetinae; Dose-Response Relationship, Drug; Drug Tolerance; Flumazenil; Male; Rats; Rats, Sprague-Dawley; Time Factors | 1996 |
Discriminative stimulus effects of flumazenil in rhesus monkeys treated chronically with chlordiazepoxide.
Topics: Animals; Anti-Anxiety Agents; Avoidance Learning; Azides; Benzodiazepines; Chlordiazepoxide; Discrimination Learning; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Antagonists; Macaca mulatta; Pharmaceutical Vehicles; Time Factors | 1997 |
Repeated administration of flumazenil does not alter its potency in modifying schedule-controlled behavior in chlordiazepoxide-treated rhesus monkeys.
Topics: Animals; Behavior, Animal; Chlordiazepoxide; Dose-Response Relationship, Drug; Female; Flumazenil; Macaca mulatta; Time Factors | 1997 |
Lactone modulation of the gamma-aminobutyric acid A receptor: evidence for a positive modulatory site.
Topics: 4-Butyrolactone; Animals; Chlordiazepoxide; Female; Flumazenil; gamma-Aminobutyric Acid; Lactones; Phenobarbital; Picrotoxin; Receptors, GABA-A; Xenopus laevis | 1997 |
Anxiolytic activity of NPY receptor agonists in the conflict test.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Chlordiazepoxide; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; Male; Neuropeptide Y; Rats; Rats, Wistar; Receptors, Neuropeptide Y | 1997 |
Dissociation of consummatory and vocal components of feeding in squirrel monkeys treated with benzodiazepines and alcohol.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Chlordiazepoxide; Conditioning, Classical; Consummatory Behavior; Ethanol; Feeding Behavior; Flumazenil; Saimiri; Social Behavior; Vocalization, Animal | 1998 |
Benzodiazepine receptor function in the chick social separation-stress procedure.
Topics: Alprazolam; Analgesia; Animals; Anti-Anxiety Agents; Chickens; Chlordiazepoxide; Disease Models, Animal; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Lorazepam; Receptors, GABA-A; Social Behavior; Stress, Psychological | 1999 |
Male olfactory cues affect mothers' behavior in mice: effects of benzodiazepines.
Topics: Animals; Benzodiazepines; Carbolines; Chlordiazepoxide; Cues; Female; Flumazenil; Lactation; Male; Maternal Behavior; Mice; Odorants; Reaction Time | 1999 |
Flumazenil induces benzodiazepine partial agonist-like effects in BALB/c but not C57BL/6 mice.
Topics: Animals; Anxiety; Avoidance Learning; Behavior, Animal; Chlordiazepoxide; Darkness; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; Light; Male; Maze Learning; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Species Specificity; Time Factors | 2000 |
Naloxone blocks 'anxiolytic' effects of neuropeptide Y.
Topics: Animals; Anti-Anxiety Agents; Chlordiazepoxide; Conflict, Psychological; Dose-Response Relationship, Drug; Flumazenil; Male; Naloxone; Narcotic Antagonists; Neuropeptide Y; Rats; Rats, Wistar | 2001 |
Interactions between LY354740, a group II metabotropic agonist and the GABA(A)-benzodiazepine receptor complex in the rat elevated plus-maze.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Bridged Bicyclo Compounds; Chlordiazepoxide; Dose-Response Relationship, Drug; Exploratory Behavior; Flumazenil; GABA Modulators; Male; Naloxone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Metabotropic Glutamate | 2001 |
5-ethoxymethyl-7-fluoro-3-oxo-1,2,3,5-tetrahydrobenzo[4,5]imidazo[1,2a]pyridine-4-N-(2-fluorophenyl)carboxamide (RWJ-51204), a new nonbenzodiazepine anxiolytic.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Central Nervous System Depressants; Chlordiazepoxide; Conflict, Psychological; Conscious Sedation; Convulsants; Drug Interactions; Ethanol; Flumazenil; GABA Modulators; Imidazoles; Lorazepam; Male; Mice; Motor Activity; Pentylenetetrazole; Postural Balance; Pyridones; Rats; Rats, Long-Evans; Receptors, GABA-A; Saimiri; Seizures | 2002 |
Benzodiazepine receptors in the medial-posterior hypothalamus mediate the reduction of hippocampal theta frequency by chlordiazepoxide.
Topics: Animals; Chlordiazepoxide; Flumazenil; GABA Modulators; Hippocampus; Hypothalamus, Middle; Hypothalamus, Posterior; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Theta Rhythm; Time Factors | 2002 |
Anxiolytic-like effects of baicalein and baicalin in the Vogel conflict test in mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Chlordiazepoxide; Conflict, Psychological; Dose-Response Relationship, Drug; Drinking; Drinking Behavior; Flavanones; Flavonoids; Flumazenil; GABA Modulators; Male; Mice; Mice, Inbred ICR; Pindolol; Psychological Tests; Serotonin Antagonists; Serotonin Receptor Agonists | 2003 |
Continuous-infusion flumazenil in the management of chlordiazepoxide toxicity.
Topics: Aged; Chlordiazepoxide; Disease Management; Flumazenil; Humans; Infusions, Intravenous; Male; Respiratory Insufficiency | 2003 |
A near-fatal overdose of carisoprodol (SOMA): case report.
Topics: Adult; Antidotes; Carisoprodol; Charcoal; Chlordiazepoxide; Clindamycin; Drug Overdose; Drug Therapy, Combination; Flumazenil; Gastric Lavage; Humans; Male; Muscle Relaxants, Central; Naloxone; Sodium Bicarbonate; Sorbitol; Temazepam; Treatment Outcome | 2004 |
Pharmacological analysis of the effects of benzodiazepines on punished schedule-induced polydipsia in rats.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Chlordiazepoxide; Diazepam; Dose-Response Relationship, Drug; Drinking; Electroshock; Fear; Flumazenil; Food Deprivation; GABA Modulators; Imidazoles; Male; Oxazepam; Punishment; Pyrimidines; Rats; Rats, Wistar; Receptors, GABA-A; Reinforcement Schedule | 2007 |
A novel operant conflict procedure using incrementing shock intensities to assess the anxiolytic and anxiogenic effects of drugs.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Aripiprazole; Benzodiazepines; Chlordiazepoxide; Conditioning, Operant; Conflict, Psychological; Dextroamphetamine; Diazepam; Electroshock; Flumazenil; Male; Piperazines; Punishment; Pyridazines; Quinolones; Rats; Rats, Sprague-Dawley; Triazoles; Yohimbine | 2009 |
Acute tolerance to chlordiazepoxide qualitatively changes the interaction between flumazenil and pregnanolone and not the interaction between flumazenil and midazolam in rhesus monkeys discriminating midazolam.
Topics: Animals; Benzodiazepines; Chlordiazepoxide; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Female; Flumazenil; GABA Modulators; Macaca mulatta; Midazolam; Pregnanolone | 2013 |
Role of gamma-aminobutyric acid type A (GABAA) receptor subtypes in acute benzodiazepine physical dependence-like effects: evidence from squirrel monkeys responding under a schedule of food presentation.
Topics: Animals; Benzodiazepines; Chlordiazepoxide; Conditioning, Operant; Dose-Response Relationship, Drug; Flumazenil; Food; GABA Antagonists; GABA Modulators; Imidazoles; Pyridines; Receptors, GABA-A; Reinforcement Schedule; Saimiri; Substance-Related Disorders; Time Factors; Zolpidem | 2013 |