flumazenil has been researched along with caffeine in 41 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (29.27) | 18.7374 |
| 1990's | 10 (24.39) | 18.2507 |
| 2000's | 7 (17.07) | 29.6817 |
| 2010's | 12 (29.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Kuribara, H; Maruyama, Y; Weintraub, ST; Yoshihama, T | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahman, M; Holmén, AG; Wan, H | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Inano, S | 1 |
| Durcan, MJ; Morgan, PF | 1 |
| Farb, DH; Friedman, L; Gibbs, TT; Roca, DJ; Rozenberg, I; Schiller, GD | 1 |
| Greenblatt, DJ; Kaplan, GB; Shader, RI; Tai, NT | 1 |
| Costa, E; Guidotti, A | 1 |
| Greenblatt, DJ; Kaplan, GB; Leduc, BW; Shader, RI; Thompson, ML | 1 |
| Baldwin, HA; File, SE | 1 |
| Gerhardt, S; Liebman, JM | 1 |
| Chweh, AY; Swinyard, EA; Ulloque, RA | 1 |
| Spealman, RD | 1 |
| Ferrario, P; Hafner, B; Mantegazza, P; Tammiso, R; Zambotti, F; Zonta, N | 1 |
| Phillis, JW; Stair, RE | 1 |
| Barbaz, BS; Bergen, KM; Bernard, PS; Boast, CA | 1 |
| Vellucci, SV; Webster, RA | 1 |
| Lee, EK; Ross, RJ; Walters, JR; Waszczak, BL | 1 |
| Ator, NA; Sannerud, CA | 1 |
| Alastra, AJ; Cohen, C; Goldberg, SR; Marley, RJ; Sannerud, CA; Serdikoff, SL | 1 |
| Kuribara, H; Maruyama, Y; Stavinoha, WB | 1 |
| Bell, CJ; Malizia, AL; Nutt, DJ | 1 |
| Bickel, WK; Smith, BJ | 1 |
| Griffiths, RR; Mintzer, MZ; Stoller, KB | 1 |
| Eyanagi, R; Imoto, M; Kuroki, H; Nishimura, S; Shimeno, H; Soeda, S; Toda, A; Uchiyama, H; Watanabe, S | 1 |
| Bi, K; Jia, Y; Li, X; Liu, A; Liu, Z; Mao, X; Zhang, C; Zhao, X | 1 |
| Caumo, W; Dos Santos, ARS; Martins, DF; Martins, TC; Medeiros, LF; Nucci-Martins, C; Siteneski, A; Souza, A; Torres, ILS | 1 |
4 review(s) available for flumazenil and caffeine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Endogenous ligands for benzodiazepine recognition sites.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Binding Sites; Binding, Competitive; Brain; Caffeine; Carrier Proteins; Chlorides; Conflict, Psychological; Diazepam Binding Inhibitor; Flumazenil; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; Hypoxanthine; Hypoxanthines; Inosine; Ion Channels; Membrane Proteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neuroglia; Neurons; Niacinamide; Organic Anion Transporters; Peptides; Phosphorylation; Protein Conformation; Protein Precursors; Receptors, GABA-A; Synaptic Membranes; Tissue Distribution; Trypsin | 1985 |
The neuropharmacology of various diazepam antagonists.
Topics: Animals; Benzodiazepinones; Caffeine; Carbolines; Diazepam; Flumazenil; Humans; Physostigmine; Pyrazoles; Receptors, Cell Surface; Receptors, GABA-A; Theophylline | 1983 |
The neurobiology of social phobia.
Topics: Brain; Caffeine; Carbon Dioxide; Cholecystokinin; Epinephrine; Female; Flumazenil; Human Growth Hormone; Humans; Hypothalamo-Hypophyseal System; Lactic Acid; Male; Neurotransmitter Agents; Panic Disorder; Phobic Disorders; Pituitary-Adrenal System; Thyroid Gland; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon | 1999 |
2 trial(s) available for flumazenil and caffeine
| Article | Year |
|---|---|
Flumazenil discrimination by humans under a two-response and a novel-response procedure.
Topics: Adolescent; Adult; Caffeine; Central Nervous System Stimulants; Discrimination, Psychological; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Modulators; Humans; Male; Midazolam; Psychomotor Performance; Triazolam | 1999 |
A controlled study of flumazenil-precipitated withdrawal in chronic low-dose benzodiazepine users.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Caffeine; Central Nervous System Stimulants; Double-Blind Method; Female; Flumazenil; GABA-A Receptor Antagonists; Humans; Male; Middle Aged; Pain Measurement; Substance Withdrawal Syndrome; Surveys and Questionnaires | 1999 |
35 other study(ies) available for flumazenil and caffeine
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
An anxiolytic-like effect of Ginkgo biloba extract and its constituent, ginkgolide-A, in mice.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Caffeine; Cyclopentanes; Diazepam; Diterpenes; Dose-Response Relationship, Drug; Furans; Ginkgo biloba; Ginkgolides; Lactones; Male; Maze Learning; Mice; Mice, Inbred Strains; Molecular Structure; Motor Activity; Phenobarbital; Plant Extracts; Plants, Medicinal; Sleep | 2003 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
[Effects of agonists and antagonists of benzodiazepine, GABA and NMDA receptors, on caffeine-induced seizures in mice].
Topics: Animals; Baclofen; Benzodiazepines; Caffeine; Diazepam; Dizocilpine Maleate; Flumazenil; Male; Mice; Muscimol; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Receptors, Purinergic; Seizures | 1992 |
Opioid receptor mediation of the hypothermic response to caffeine.
Topics: Animals; Body Temperature; Caffeine; Dose-Response Relationship, Drug; Drug Interactions; Flumazenil; Male; Metergoline; Mice; Naloxone; Receptors, Opioid; Sympatholytics | 1992 |
gamma-Aminobutyric acidA receptor regulation in culture: altered allosteric interactions following prolonged exposure to benzodiazepines, barbiturates, and methylxanthines.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Allosteric Regulation; Animals; Barbital; Barbiturates; Brain; Caffeine; Cells, Cultured; Chick Embryo; Flumazenil; Flunitrazepam; Flurazepam; gamma-Aminobutyric Acid; Kinetics; Neurons; Pentobarbital; Receptors, GABA-A; Tetrodotoxin; Theophylline; Veratridine | 1990 |
Separate and combined effects of caffeine and alprazolam on motor activity and benzodiazepine receptor binding in vivo.
Topics: Alprazolam; Animals; Brain Chemistry; Caffeine; Chromatography, High Pressure Liquid; Drug Interactions; Flumazenil; Male; Mice; Motor Activity; Receptors, GABA-A; Xanthines | 1990 |
Relationship of plasma and brain concentrations of caffeine and metabolites to benzodiazepine receptor binding and locomotor activity.
Topics: Adenosine; Animals; Brain; Caffeine; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Flumazenil; Male; Mice; Motor Activity; Receptors, GABA-A | 1989 |
Caffeine-induced anxiogenesis: the role of adenosine, benzodiazepine and noradrenergic receptors.
Topics: 2-Chloroadenosine; Adenosine; Alprazolam; Anxiety; Caffeine; Chlordiazepoxide; Clonidine; Flumazenil; Motor Activity; Muscle Relaxants, Central; Norepinephrine; Propranolol; Receptors, Adrenergic; Receptors, GABA-A; Receptors, Purinergic; Social Behavior | 1989 |
Self-regulation of ICSS duration: effects of anxiogenic substances, benzodiazepine antagonists and antidepressants.
Topics: Adrenergic alpha-Antagonists; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Benzodiazepinones; Caffeine; Carbolines; Conditioning, Operant; Convulsants; Flumazenil; Humans; Male; Pentylenetetrazole; Pyrazoles; Rats; Rats, Inbred F344; Self Stimulation; Time Factors | 1985 |
Benzodiazepine inhibition of [3H]flunitrazepam binding and caffeine-induced seizures in mice.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Binding, Competitive; Caffeine; Flumazenil; Flunitrazepam; Male; Mice; Receptors, GABA-A; Seizures | 1986 |
Discriminative-stimulus effects of midazolam in squirrel monkeys: comparison with other drugs and antagonism by Ro 15-1788.
Topics: Animals; Azabicyclo Compounds; Barbital; Benzodiazepines; Benzodiazepinones; Buspirone; Caffeine; Chlordiazepoxide; Cinanserin; Clozapine; Conditioning, Operant; Cyproheptadine; Diazepam; Diphenhydramine; Discrimination Learning; Electroshock; Flumazenil; Male; Midazolam; Muscimol; Nordazepam; Pentobarbital; Piperazines; Pyridazines; Pyrimidines; Saimiri; Tripelennamine | 1985 |
Reversal of the effect of centrally-administered diazepam on morphine antinociception by specific (Ro 15-1788 and Ro 15-3505) and non-specific (bicuculline and caffeine) benzodiazepine antagonists.
Topics: Animals; Benzodiazepinones; Bicuculline; Caffeine; Diazepam; Flumazenil; Injections, Intraventricular; Male; Morphine; Pain; Rats; Rats, Inbred Strains | 1986 |
Ro 15-1788 both antagonizes and potentiates adenosine-evoked depression of cerebral cortical neurons.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Cerebral Cortex; Evoked Potentials; Flumazenil; Male; Rats; Rats, Inbred Strains | 1987 |
Antagonism of caffeine-induced seizures in mice by Ro15-1788.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Caffeine; Diazepam; Female; Flumazenil; Mice; Receptors, Drug; Seizures | 1984 |
Effects of benzodiazepines on single unit activity in the substantia nigra pars reticulata.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Bicuculline; Caffeine; Diazepam; Dose-Response Relationship, Drug; Electric Conductivity; Flumazenil; Flurazepam; Male; Neurons; Picrotoxin; Rats; Rats, Inbred Strains; Substantia Nigra; Theophylline | 1982 |
Drug discrimination analysis of midazolam under a three-lever procedure: I. Dose-dependent differences in generalization and antagonism.
Topics: Animals; Caffeine; Cocaine; Dextroamphetamine; Discrimination Learning; Dose-Response Relationship, Drug; Flumazenil; Male; Methocarbamol; Midazolam; Morphine; Pentobarbital; Rats; Rats, Sprague-Dawley | 1995 |
Tolerance to the behavioral effects of chlordiazepoxide: pharmacological and biochemical selectivity.
Topics: Amphetamine; Animals; Behavior, Animal; Caffeine; Carbolines; Chlordiazepoxide; Chlorides; Chlorine; Dose-Response Relationship, Drug; Drug Tolerance; Flumazenil; gamma-Aminobutyric Acid; Male; Midazolam; Morphine; Pentobarbital; Radioisotopes; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sensitivity and Specificity; Stimulation, Chemical | 1993 |
Behavioural pharmacological characteristics of honokiol, an anxiolytic agent present in extracts of Magnolia bark, evaluated by an elevated plus-maze test in mice.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Bicuculline; Biphenyl Compounds; Caffeine; Central Nervous System Depressants; Central Nervous System Stimulants; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GABA Antagonists; GABA Modulators; Injections, Subcutaneous; Lignans; Male; Maze Learning; Mice; Mice, Inbred BALB C; Motor Activity; Tetragastrin; Therapeutic Equivalency | 1998 |
The stimulatory effects of caffeine with oseltamivir (Tamiflu) on light-dark behavior and open-field behavior in mice.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Antiviral Agents; Caffeine; Darkness; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Exploratory Behavior; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Haloperidol; Male; Mice; Motor Activity; Neurotransmitter Agents; Oseltamivir; Pyrimidines; Random Allocation; Triazoles; Xanthines | 2010 |
Pharmacological evaluation of sedative and hypnotic effects of schizandrin through the modification of pentobarbital-induced sleep behaviors in mice.
Topics: 5-Hydroxytryptophan; Animals; Caffeine; Cyclooctanes; Fenclonine; Flumazenil; Fruit; GABA Antagonists; Hypnotics and Sedatives; Lignans; Locomotion; Male; Mice; Pentobarbital; Polycyclic Compounds; Sleep | 2014 |
Neurobiological mechanisms of antiallodynic effect of transcranial direct current stimulation (tDCS) in a mice model of neuropathic pain.
Topics: Adenosine A1 Receptor Antagonists; Animals; Caffeine; Central Nervous System Stimulants; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Flumazenil; GABA Modulators; Hyperalgesia; Male; Mice; Morpholines; Naloxone; Narcotic Antagonists; Neuralgia; Pain Threshold; Physical Stimulation; Pyrazoles; Transcranial Direct Current Stimulation; Xanthines | 2018 |