floxuridine has been researched along with methotrexate in 228 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 179 (78.51) | 18.7374 |
| 1990's | 29 (12.72) | 18.2507 |
| 2000's | 10 (4.39) | 29.6817 |
| 2010's | 10 (4.39) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Chabner, BA; Donehower, RC; Myers, CE | 1 |
| Chabner, BA; Coleman, CN; Johns, DG; Myers, CE | 1 |
| Morgenthaler, FR; Pettavel, J | 2 |
| Carter, SK; Wasserman, TH | 1 |
| Groth, DP; Kinkade, JM; Ross, DD | 1 |
| Kalman, TI | 1 |
| Roberts, D; Warmath, EV | 1 |
| Lin, H | 1 |
| Forsdyke, DR; Scott, FW | 1 |
| Brunk, CF; Yaffe, D | 1 |
| Bogenhagen, D; Clayton, DA | 1 |
| Irvin, AD; Stagg, DA | 1 |
| Bonner, EL; Elford, HL; Hanna, SD; Kerr, BH; Smulson, M | 1 |
| Fioretti, MC; Giampietri, A; Goldin, A; Puccetti, P; Riccardi, C | 1 |
| Lee, M; Martin, DW; Santi, DV; Ullman, B | 1 |
| Biermann, WA; Haurani, FI; Kardinal, CG | 1 |
| Alfonso, A; Bohorquez, J; Gardner, B; Harshaw, D; Hassan, A; Herbsman, H; Newman, J | 1 |
| Jackson, RC | 1 |
| Schempp, W; Sigwarth, I; Vogel, W | 1 |
| Azizkhan, JC; Goode, D; Speeg, KV; Stromberg, K | 1 |
| Heidelberger, C; Moran, RG; Mulkins, M | 1 |
| Oberfield, RA | 3 |
| Jackson, RC; Weber, G | 1 |
| Cady, B; Oberfield, RA; Wellwood, JM | 1 |
| de Smidt, PC; van Berkel, TJ | 2 |
| Aran, JM; Plagemann, PG | 1 |
| Aschele, C; Bertino, JR; Faderan, MA; Sobrero, A | 1 |
| Cardinale, I; Sehgal, PB; Tamm, I | 1 |
| Azizkhan, JC; Eastman, HB; Schmitt, MC; Swick, AG | 1 |
| Allegra, CJ; Chabner, BA; Chu, E; Grem, JL; Johnson, P; Yeh, GC | 1 |
| Firestone, WM; FitzGerald, GB; Wick, MM | 1 |
| Bertino, JR; Romanini, A | 1 |
| Allegra, CJ; Chabner, BA; Drake, JC; Jolivet, J; Lutz, R; Rodbard, D | 1 |
| Balińska, M | 1 |
| Allegra, CJ; Baram, J; Drake, JC; Hoang, K; Yeh, GC | 1 |
| Lönn, S; Lönn, U | 2 |
| Aiba, K; Allegra, CJ; Baram, J; Chabner, BA; Curt, GA; Yeh, GC | 1 |
| Lönn, S; Lönn, U; Nylen, U; Winblad, G | 1 |
| Baba, T; Furukohri, N; Itoh, T; Munakata, A; Ogasawara, H; Saitoh, S; Sakata, Y; Tamura, Y; Tsushima, K; Yoshida, Y | 1 |
| Kesseler, J; Ploss, HJ; Schmitz, R; Zanea-Wangler, E | 1 |
| Bertino, JR; Nicolin, A; Romanini, A; Rosso, R; Russello, O; Sobrero, A | 1 |
| Goldman, ID; Mikulecky, DC; Rape, TJ; Seither, RL; Trent, DF | 1 |
| Bowen, D; Robbins, TJ; White, RM | 1 |
| Bazin, C; Le Menn, A; Silber, J | 1 |
| Kashani-Sabet, M; Scanlon, KJ; Sowers, LC | 1 |
| Carl, PL; Goz, B; Tlsty, TD | 1 |
| Friedman, SJ; Green, BJ; Hoar, DI; Inoue, M; Matheson, DS | 1 |
| Hustinx, TW; Scheres, JM; Smeets, DF | 1 |
| Herrmann, R | 1 |
| FitzGerald, GB; Wick, MM | 1 |
| Doria, MI; DuBrow, RA; Faintuch, J; Levin, B; Riddell, RH; Shepard, KV | 1 |
| Fujita, F; Fujita, M; Inaba, H; Sakamoto, Y; Shimozuma, K; Taguchi, T | 1 |
| Baker, E; Eichenbaum, SZ; Hockey, A; Krumins, E; Purvis-Smith, S; Sutherland, GR | 1 |
| Fisher, K; Flam, M; Gandara, D; Hannigan, J; Hendrickson, C; Kohler, M; Richman, E; Valone, FH; Yu, KP | 1 |
| FitzGerald, GB; Ratliff, J; Wick, MM | 1 |
| Goldman, ID; Gorse, KM; Schuetz, JD; Westin, EH | 1 |
| Wawra, E | 1 |
| Cagnazzo, P; Cardi, G; Ficorella, C; Frati, L; Marchei, P; Marchetti, P; Ricciuti, FP | 1 |
| Glimelius, B; Påhlman, L | 1 |
| Beschorner, J; Cooper, RM; DuBrow, RA; Faintuch, J; Hagle, M; Karl, RC; Levin, B; Shepard, KV; Stablein, D | 1 |
| Kobayashi, T | 1 |
| Benedict, WF; Heidelberger, C; Peterson, AR | 1 |
| Bertino, JR; Handschumacher, RE; Moir, RD; Sobrero, AF | 1 |
| Bertino, JR; Handschumacher, RE; Sobrero, AF | 1 |
| Barbi, G; Djalali, M; Steinbach, P | 1 |
| Kalman, TI; Yalowich, JC | 1 |
| Johnson, RO; Sedransk, N; Shingleton, WW | 1 |
| Couture, J; Deschênes, L | 1 |
| Morgenthaler, F; Pettavel, J | 2 |
| Casale, C; Cortese, M; Nervi, C | 2 |
| Watne, AL | 1 |
| Houlihan, RB; Roby, R; Teskey, C | 1 |
| Pettavel, J | 1 |
| Modest, EJ | 1 |
| Eker, P | 1 |
| Lang, A; Nitsan, J | 2 |
| Cappuccino, JG; Schmid, FA; Stock, CC; Tarnowski, GS | 1 |
| Bradner, WT; Pindell, MH | 1 |
| Gerhartz, H; Hampel, KE; Kober, B; Meinig, KH; Rösch, D | 1 |
| Rochlin, DB; Smart, CR | 1 |
| Canellos, GP; Greenberg, NH; Mead, JA; Schrecker, AW | 1 |
| Reiner, J; Southam, CM | 1 |
| Cassidy, EP; Fischer, DS; Welch, AD | 1 |
| Foley, GE; Lazarus, H | 1 |
| Oberfield, RA; Sullivan, RD | 1 |
| Handa, H; Mori, K; Onoyama, Y | 1 |
| Bender, E; Geissler, E | 1 |
| Bertino, JR; Hillcoat, BL; Swett, V | 1 |
| Grossowicz, N; Mandelbaum-Shavit, F | 1 |
| Hunt, DE; Pittillo, RF | 1 |
| Kolb, B; Ramseier, L; Schindler, R | 1 |
| Hoshino, T; Nagai, M; Sano, K | 1 |
| Hampel, KE | 1 |
| Dendy, PP | 1 |
| Steffen, JA; Stolzmann, WM | 1 |
| Kustova, OV; Lomakina, LIa | 1 |
| Ockey, CH; Williams, CA | 1 |
| Couture, J; Deschênes, L; Poulin, F | 1 |
| Baumunk, CN; Friedman, DL | 1 |
| Fox, M; Nias, AH | 1 |
| Werkheiser, WC | 1 |
| Ockey, CH | 1 |
| Grindey, GB; Nichol, CA | 1 |
| Makulu, DR | 1 |
| Conrad, AH; Ruddle, FH | 1 |
| Divekar, AY; Fleysher, MH; Hakala, MT; Kenny, LN; Slocum, HK | 1 |
| Adamson, DJ; Bowdon, BJ; Vail, MH; Wheeler, GP | 1 |
| Zeuthen, E | 1 |
| Grindey, GB; Moran, RG; Nichol, CA; Werkheiser, WC | 1 |
| Prescott, DM; Wise, GE | 1 |
| Booth, JC; Cady, B; Oberfield, RA | 1 |
| Harrap, KR; Jackson, RC | 1 |
| Forsdyke, DR; Sjostrom, DA | 1 |
| Chu, MY; Hoovis, ML | 1 |
| Deits, T; Jerkunica, I; Whiteley, JM | 2 |
| DeFoor, PH; Stubblefield, E | 1 |
| Santi, DV; Sommer, H | 1 |
| Selawry, OS | 1 |
| Carter, SK; Comis, RL | 1 |
| Temin, HM | 1 |
| Baluda, MA; Brodetsky, AM; Knudson, AG | 1 |
| Bertino, JR; Fernandes, DJ | 1 |
| Benz, C; Cadman, E | 1 |
| Bowen, D; Gewirtz, DA; Goldman, D | 1 |
| Daniel, A; Ekblom, L; Phillips, S | 1 |
| Creaven, PJ; Madajewicz, S; Mittelman, A | 1 |
| Barclay, BJ; Haynes, RH; Kunz, BA; Little, JG | 1 |
| Deering, RA; Michrina, CA | 1 |
| Bestwick, RK; Mathews, CK; Moffett, GL | 1 |
| Washtien, WL | 1 |
| Ensminger, WD; Keller, JH | 1 |
| Gollakota Rao, L; Johnson, LF; Rossana, C | 1 |
| Garson, OM; Webber, LM | 1 |
| Burry, RW | 1 |
| Jastreboff, MM; Kedzierska, B; Rode, W | 1 |
| Goulian, M; Ingraham, HA; Peterson, MS | 1 |
| Kimura, K; Tanaka, M; Yoshida, S | 1 |
| Bernheim, JL; Naaktgeboren, N; Roobol, K; Theunissen, J | 1 |
| Bedikian, AY | 1 |
| Anness, V; Chitham, RG; Haslam, JS; Taylor, JW | 1 |
| Nielsen, KB; Tommerup, N | 1 |
| Flickinger, RA; Richman, R | 1 |
| Bailey, BD; Bowen, D; Guernsey, LA | 1 |
| Inman, RB | 1 |
| Barbi, G; Steinbach, P; Vogel, W | 1 |
| Coronnello, M; Criscuoli, L; Gualtieri, M; Mazzei, T; Mini, E; Periti, P | 1 |
| Rittenberg, SC; Rosson, RA | 1 |
| Chandler, WF; Doan, KM; Ensminger, WD; Greenberg, HS; Gyves, JW; Kindt, GW; Phillips, TW; Seeger, JF | 1 |
| Friedman, MA | 1 |
| Butt, TR; Sreevalsan, T | 1 |
| Beck, WS; Pelliniemi, TT | 1 |
| Bowen, D; Fölsch, E; Guernsey, LA | 2 |
| Allegra, JC; Chabner, BA; Donehower, RC; Lippman, ME | 1 |
| Hill, DL; Montgomery, JA | 1 |
| Scott, JM; Weir, DG | 1 |
| Ayusawa, D; Koyama, H; Seno, T | 1 |
| Dardick, I; Dubsky, M; Kiss, G; Setterfield, G; Sheinin, R | 1 |
| Kikuchi, Y; Yamamoto, KI | 1 |
| Higashikuni, N; Sutou, S | 1 |
| Almasan, A; Banerjee, D; Bertino, JR; Fan, J; Hochhauser, D; Kelly, R; Li, W; Wahl, GM; Yin, Y; Zielinski, Z | 1 |
| Ito, T; Komatsu, Y; Moriya, N; Ogasawara, H; Saito, S; Sakata, Y; Sugimoto, N; Tamura, Y; Tsushima, K; Yamada, Y | 2 |
| Chevillard, S; Le Menn, A; Paumard, S; Silber, J; Zider, A | 1 |
| Haile, WH; Heitzman, KJ; McCloskey, DE; McGuire, JJ; Piper, JR; Russell, CA | 1 |
| Allegra, CJ; Chabner, BA; Chu, E; Grem, JL; Johnston, PG; Politi, PM; Takimoto, CH | 1 |
| Prichard, LE; Prichard, MN; Shipman, C | 1 |
| Ahlgren, JD; Anderson, N; Kemeny, N; Lokich, JJ | 1 |
| Malmberg, M; Rustum, YM; Slocum, HK; Yin, MB; Zhang, ZG | 1 |
| Higashi, Y; Inoue, K; Kanoh, T; Kurihara, T; Suemasu, K; Tabei, T | 1 |
| Bartier, WA; Huschtscha, LI; Ross, CE; Tattersall, MH | 1 |
| Bamberger, U; Boven, E; Feller, N; Jansen, WJ; Pinedo, HM; van der Wilt, CL | 1 |
| Bulian, D; Kreft, B; Kurth, S; Riemenschneider, T | 1 |
| Ahluwalia, GS; Gao, WY; Johns, DG; Mitsuya, H | 1 |
| Bolanowska, WE; Coward, JK; Galivan, J; Haile, WH; Hart, BP; Magee, KJ; McGuire, JJ; Paul, B; Rhee, M; Russell, C | 1 |
| Collins, MK; López-Rivas, A; Oliver, FJ | 1 |
| Bajetta, E; Biganzoli, L; Buzzoni, R; Carnaghi, C; Cassata, A; Di Bartolomeo, M; Galante, E; Mariani, L; Spagnoli, I; Stampino, CG | 1 |
| Fukuda, K; Kim, YH; Kitano, H; Kokufu, I; Taniguchi, H; Yamada, K; Yamamoto, M; Yano, T | 1 |
| Buyse, M; Haddad, E; Piedbois, P; Thirion, P; Wolmark, N | 1 |
| Hohya, I; Idezuki, Y; Ishida, H; Nakada, H; Suzuki, T; Takeuchi, I; Yamada, H | 1 |
| Collins, MK; Gutierrez del Arroyo, A; Palacios, C; Silva, A | 1 |
| Burzykowski, T; Buyse, M; Carlson, RW; Molenberghs, G; Piedbois, P; Thirion, P | 1 |
| Croockewit, A; Koopmans, PP; Lekkerkerker, JF; Schellens, J; van Bronswijk, H | 1 |
| Collins, MK; Leverrier, Y; Low, W; Madsen, C; Olmos-Centenera, G | 1 |
| Ito, T; Nakamura, A; Sato, A; Taguchi, S; Tomita, T | 1 |
| HALL, TC | 1 |
| BAGSHAW, MA | 1 |
| NORCROSS, JW; SULLIVAN, RD; WATKINS, E | 1 |
| SULLIVAN, RD; WATKINS, E | 2 |
| CLIFFORD, P | 1 |
| FRIEDKIN, M | 1 |
| ANDERSON, EP; BROCKMAN, RW | 1 |
| MILLER, E; SULLIVAN, RD | 1 |
| DIPAOLO, JA; DOWD, JE; WATNE, AL | 1 |
| SULLIVAN, RD; ZUREK, WZ | 1 |
| OWENS, AH; SANTOS, GW | 1 |
| OETTGEN, HF | 1 |
| ROGERS, LS | 1 |
| GENTRY, GA; LAWSON, LA; RANDALL, CC | 1 |
| MORSE, PA; POTTER, VR | 1 |
| HODAS, S; YOUNG, CW | 1 |
| FISCHER, GA; VONESSEN, CF | 1 |
| Hamada, T; Ichimura, W; Minagawa, N; Mino, K; Naito, H; Orimo, T; Shibazaki, W; Shinohara, T | 1 |
| Cao, Y; Feng, F; Xiang, Y | 1 |
| Nakayama, T; Noguchi, S | 1 |
| Ait-Tihyaty, M; Jean-Claude, BJ; Mihalcioiu, C; Rachid, Z | 1 |
| Jafari, M; Kislukhin, G; Long, AD; Murphy, ML | 1 |
| Azad, NA; Kern, SE; Patel, K; Yerram, SR | 1 |
| Bhinder, B; Djaballah, H; Fischer, MA; Früh, K; Hirsch, AJ; Nelson, JA; Parkins, C; Radu, C; Shum, D; Smith, JL; Stein, DA | 1 |
| Wang, D; Wu, J | 1 |
25 review(s) available for floxuridine and methotrexate
| Article | Year |
|---|---|
The clinical pharmacology of antineoplastic agents (first of two parts).
Topics: Animals; Antineoplastic Agents; Asparaginase; Binding Sites; Biological Transport; Chemical and Drug Induced Liver Injury; Depression, Chemical; DNA, Neoplasm; Drug Interactions; Drug Resistance; Floxuridine; Fluorouracil; Folic Acid Antagonists; Humans; Kidney Diseases; Liver; Lung Diseases; Methotrexate; Mice; Neoplasms; Tetrahydrofolate Dehydrogenase | 1975 |
Radiation sensitizers.
Topics: Animals; Antineoplastic Agents; Bromodeoxycytidine; Bromodeoxyuridine; Carcinoma; Deoxyuridine; Dogs; Dose-Response Relationship, Radiation; Floxuridine; Humans; Hypoxia; Idoxuridine; Lung Neoplasms; Methotrexate; Metronidazole; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Research; Sarcoma, Experimental; Skin | 1976 |
Antimetabolites.
Topics: Animals; Antimetabolites; Antineoplastic Agents; Cytarabine; Cytidine; Drug Interactions; Drug Resistance; Floxuridine; Fluorouracil; Folic Acid Antagonists; Humans; Methotrexate; Neoplasms | 1991 |
Antimetabolites.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Cytarabine; Floxuridine; Fluorouracil; Folic Acid Antagonists; Humans; Mercaptopurine; Methotrexate; Purines; Thioguanine | 1987 |
Cytostatic drug therapy in disseminated colorectal cancer.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Leucovorin; Methotrexate; Semustine; Vincristine | 1988 |
Oncogenic transformation of C3H/10T1/2 Cl 8 mouse embryo fibroblasts by inhibitors of nucleotide metabolism.
Topics: Animals; Bromodeoxyuridine; Cell Line; Cell Transformation, Neoplastic; Cytidine; Deoxycytidine; Deoxyribonucleotides; DNA; Embryo, Mammalian; Fibroblasts; Floxuridine; Fluorouracil; Idoxuridine; Methotrexate; Mice; Mice, Inbred C3H; Mutation; Thymidine; Trifluridine | 1985 |
Solid tumor chemotherapy: What have we to offer.
Topics: Adult; Antineoplastic Agents; Child; Cyclophosphamide; Dactinomycin; Floxuridine; Fluorouracil; Humans; Hydroxyurea; Methotrexate; Neoplasms; Nitrogen Mustard Compounds; Palliative Care; Thiotepa; Time Factors; Vincristine | 1970 |
Synchronization of mammalian cells with respect to the mitotic cycle.
Topics: Animals; Antineoplastic Agents; Autoradiography; Calcium; Carbon Isotopes; Cattle; Cell Count; Cell Differentiation; Cell Line; Cells; Cells, Cultured; Centrifugation, Density Gradient; Clone Cells; Cold Temperature; Cricetinae; Culture Techniques; DNA; Female; Floxuridine; Guinea Pigs; HeLa Cells; Humans; Hydroxyurea; Iodine Isotopes; Kinetics; L Cells; Liver; Methods; Methotrexate; Mice; Mitosis; Ovary; RNA; Statistics as Topic; Thymidine; Time Factors; Tritium | 1971 |
Synchronization of the Tetrahymena cell cycle.
Topics: Animals; Antimalarials; Carbon Isotopes; Cell Division; Cell Nucleus; Culture Media; DNA; DNA Replication; Floxuridine; Hot Temperature; Methotrexate; Morphogenesis; Nucleosides; Protein Biosynthesis; Temperature; Tetrahymena; Tetrahymena pyriformis; Thymidine; Time Factors; Transcription, Genetic; Tritium; Uridine | 1971 |
Monochemotherapy of bronchogenic carcinoma withs special reference to cell type.
Topics: Adenocarcinoma; Alkylating Agents; Antineoplastic Agents; Carcinoma, Bronchogenic; Cytarabine; Dactinomycin; Daunorubicin; Doxorubicin; Floxuridine; Humans; Hydroxyurea; Lung Neoplasms; Mechlorethamine; Methotrexate; Mitomycins; Nitrosourea Compounds; Plicamycin; Porfiromycin; Procarbazine; Streptonigrin; Thiotepa; Vinblastine | 1973 |
A review of chemotherapy in gastric cancer.
Topics: Adenocarcinoma; Antineoplastic Agents; Carmustine; Chlorambucil; Chromomycins; Cyclophosphamide; Cytarabine; Drug Evaluation; Drug Therapy, Combination; Floxuridine; Fluorouracil; Humans; Mechlorethamine; Methotrexate; Mitomycins; Nitrosourea Compounds; Olivomycins; Stomach Neoplasms | 1974 |
Some considerations in the experimental approach to distinguishing between membrane transport and intracellular disposition of antineoplastic agents, with specific reference to fluorodeoxyuridine, actinomycin D, and methotrexate.
Topics: Animals; Antineoplastic Agents; Biological Transport; Biotransformation; Cell Membrane; Dactinomycin; Deoxyuridine; Floxuridine; Humans; Kinetics; Liver; Methotrexate; Polyglutamic Acid; Tritium | 1981 |
New potential treatment modalities for disseminated prostatic cancer.
Topics: Androgen Antagonists; Animals; Antibiotics, Antineoplastic; Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Castration; Combined Modality Therapy; Cyclophosphamide; Floxuridine; Folic Acid Antagonists; Hormones; Humans; Interferons; Isomerism; Male; Methotrexate; Naphthacenes; Nitrosourea Compounds; Organoplatinum Compounds; Prostatic Neoplasms; Thymus Hormones; Tumor Stem Cell Assay | 1984 |
Regional and systemic chemotherapy for advanced colorectal cancer. A review.
Topics: Antineoplastic Agents; Aspartic Acid; Chemotherapy, Cancer, Regional Perfusion; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Floxuridine; Hepatic Artery; Humans; Infusions, Intra-Arterial; Methotrexate; Phosphonoacetic Acid; Rectal Neoplasms; Tegafur | 1983 |
Hepatic intraarterial chemotherapy--current status and future prospects--"If you have a short sword, take a step forward".
Topics: Carcinoma, Hepatocellular; Catheterization; Colonic Neoplasms; Doxorubicin; Floxuridine; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Methotrexate; Rectal Neoplasms | 1983 |
Selective uptake and retention of anticancer agents by sensitive cells.
Topics: Animals; Antineoplastic Agents; Cytarabine; Doxorubicin; Floxuridine; Fluorouracil; Humans; Melphalan; Methotrexate; Neoplasms | 1980 |
Drug-induced megaloblastic change.
Topics: Cyclophosphamide; Cytarabine; DNA; Erythrocytes, Abnormal; Floxuridine; Fluorouracil; Folic Acid Antagonists; Humans; Hydroxyurea; Megaloblasts; Methotrexate; Phenytoin; Pyrimethamine; Ribonucleotides; Thymidine Monophosphate; Thymidylate Synthase; Triamterene; Trimethoprim | 1980 |
Antimetabolites.
Topics: Antimetabolites, Antineoplastic; Cytarabine; Drug Design; Drug Resistance; Floxuridine; Fluorouracil; Humans; Methotrexate; Purines | 1993 |
Recent advances in the treatment of advanced colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Drug Administration Schedule; Drug Interactions; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Hydroxyurea; Infusions, Intra-Arterial; Leucovorin; Methotrexate; Neoplasm Staging; Phosphonoacetic Acid; Prospective Studies; Randomized Controlled Trials as Topic | 1993 |
Survival impact of chemotherapy in patients with colorectal metastases confined to the liver: a re-analysis of 1458 non-operable patients randomised in 22 trials and 4 meta-analyses. Meta-Analysis Group in Cancer.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Evaluation Studies as Topic; Female; Floxuridine; Fluorouracil; Humans; Injections, Intralesional; Liver Neoplasms; Male; Methotrexate; Middle Aged; Palliative Care; Prognosis; Randomized Controlled Trials as Topic; Survival Analysis; Terminally Ill; Treatment Outcome | 1999 |
Relation between tumour response to first-line chemotherapy and survival in advanced colorectal cancer: a meta-analysis. Meta-Analysis Group in Cancer.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Floxuridine; Fluorouracil; Leucovorin; Methotrexate; Randomized Controlled Trials as Topic; Survival Analysis; Treatment Outcome | 2000 |
[Chemotherapy of gastric cancer--a review of clinical trials in Japan].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Drug Administration Schedule; Drug Combinations; Floxuridine; Humans; Japan; Methotrexate; Mitomycin; Stomach Neoplasms; Survival Analysis; Tegafur; Uracil | 2002 |
ENZYMATIC ASPECTS OF FOLIC ACID.
Topics: Amidohydrolases; Aminopterin; Chromatography; Clostridium; Escherichia coli; Floxuridine; Folic Acid; Ligases; Liver; Lyases; Methionine; Methotrexate; Micrococcus; Oxidoreductases; Pseudomonas; Research; Spectrophotometry; Transferases; Tritium; Vitamin B 12 | 1963 |
BIOCHEMISTRY OF CANCER (METABOLIC ASPECTS).
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Azaguanine; Azaserine; Carcinoma, Ehrlich Tumor; DNA; DNA, Neoplasm; Floxuridine; Fluorouracil; Folic Acid; Glutamine; Leukemia L1210; Mercaptopurine; Methotrexate; Mitomycin; Neoplasms; Neoplasms, Experimental; Pharmacology; Purines; Puromycin; Pyrimidines; Research; RNA; RNA, Neoplasm; Thioguanine; Thiouracil | 1963 |
Therapeutic usefulness of postoperative adjuvant chemotherapy with Tegafur-Uracil (UFT) in patients with breast cancer: focus on the results of clinical studies in Japan.
Topics: Administration, Oral; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Chemotherapy, Adjuvant; Cisplatin; Clinical Trials as Topic; Deoxycytidine; Drug Combinations; Female; Floxuridine; Fluorouracil; Humans; Japan; Methotrexate; Oxonic Acid; Tegafur; Uracil | 2010 |
5 trial(s) available for floxuridine and methotrexate
| Article | Year |
|---|---|
A Northern California Oncology Group randomized trial of leucovorin plus 5-fluorouracil versus sequential methotrexate, 5-fluorouracil, and leucovorin in patients with advanced colorectal cancer who failed treatment with 5-fluorouracil or 5-fluorodeoxyuri
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Colonic Neoplasms; Drug Administration Schedule; Drug Resistance; Floxuridine; Fluorouracil; Humans; Leucovorin; Methotrexate; Rectal Neoplasms | 1987 |
Cytostatic drug therapy in disseminated colorectal cancer.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Leucovorin; Methotrexate; Semustine; Vincristine | 1988 |
[Randomized controlled study of sequential methotrexate and 5-fluorouracil therapy with or without 5'-deoxy-5-fluorouridine against advanced gastrointestinal cancer. Hirosaki Cooperative Study Group for Cancer Chemotherapy].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Quality of Life; Survival Analysis | 1994 |
[Sequential methotrexate/5-fluorouracil therapy with 5'-deoxy-5-fluorouridine against advanced gastric cancer: comparison between bolus injection and drip infusion of 5-fluorouracil administration. Hirosaki Cooperative Study Group for Cancer Chemotherapy]
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Alopecia; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Injections, Intravenous; Leukopenia; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Stomach Neoplasms | 1994 |
Oral doxifluridine plus levoleucovorin in elderly patients with advanced breast cancer.
Topics: Administration, Oral; Aged; Aged, 80 and over; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Methotrexate; Neoplasm Staging | 1998 |
199 other study(ies) available for floxuridine and methotrexate
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
New developments on the mechanisms of action of antineoplastic drugs.
Topics: Antineoplastic Agents; Bleomycin; Doxorubicin; Drug Interactions; Drug Synergism; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Methotrexate | 1979 |
[Treatment of primary and secondary liver tumors using a combination of chemotherapy and surgery].
Topics: Antineoplastic Agents; Carmustine; Drug Therapy, Combination; Floxuridine; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Methods; Methotrexate; Remission, Spontaneous; Vincristine | 1975 |
The chemotherapy of urologic cancer.
Topics: Adenocarcinoma; Adult; Aged; Alkylating Agents; Antineoplastic Agents; Doxorubicin; Drug Therapy, Combination; Estradiol; Female; Floxuridine; Fluorouracil; Humans; Hydroxyurea; Kidney Neoplasms; Male; Methotrexate; Middle Aged; Mitomycins; Plicamycin; Prostatic Neoplasms; Testicular Neoplasms; Thiotepa; Urinary Bladder Neoplasms; Urogenital Neoplasms; Vincristine | 1975 |
Effects of urinary proteins from certain leukemics upon macromolecular synthesis and enzyme levels in bone marrow cultures.
Topics: Adenine Phosphoribosyltransferase; Amidophosphoribosyltransferase; Animals; Bone Marrow; Bone Marrow Cells; Cell Division; Cells, Cultured; Deoxyuridine; DNA; Female; Floxuridine; Humans; Leukemia; Male; Methotrexate; Mice; Mice, Inbred C57BL; Muramidase; Neoplasm Proteins; Proteinuria; RNA; Thymidine Kinase | 1975 |
Molecular aspects of the mechanism of action of 5-fluorodeoxyuridine.
Topics: Deuterium; Floxuridine; Isotope Labeling; Kinetics; Lacticaseibacillus casei; Mathematics; Methotrexate; Methyltransferases; Molecular Conformation; Thymidylate Synthase | 1975 |
Methotrexate inhibition of CCRF-CEM cultures of human lymphoblasts.
Topics: Cell Division; Cell Line; Deoxycytidine; Deoxyuridine; DNA, Neoplasm; Floxuridine; Folic Acid Antagonists; Humans; Hypoxanthines; Leucovorin; Leukemia, Lymphoid; Methotrexate; Purines; Thymidine | 1975 |
Schedule-dependent effect of phase-specific cytotoxic agents on production of hemolytic plaque-forming cells.
Topics: Animals; Antineoplastic Agents; Cytarabine; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Male; Methotrexate; Mice; Mice, Inbred AKR; Time Factors | 1976 |
Isotope-dilution studies of the effects of 5-fluorodeoxyuridine and hydroxyurea on the incorporation of deoxycytidine and thymidine by cultured thymus cells.
Topics: Animals; Cells, Cultured; Cytidine; Deoxyadenosines; Deoxycytidine; Deoxyribonucleosides; DNA Replication; Floxuridine; Hydroxyurea; Methotrexate; Rats; Thymidine; Thymus Gland | 1976 |
The reversible inhibition of myoblast fusion by ethidium bromide (EB).
Topics: Cell Fusion; Cells, Cultured; Chloramphenicol; Cytarabine; DNA; Dose-Response Relationship, Drug; Ethidium; Floxuridine; Hydroxyurea; Methotrexate; Protein Biosynthesis; Rifampin; RNA; Thymidine | 1976 |
Thymidylate nucleotide supply for mitochondrial DNA synthesis in mouse L-cells. Effect of 5-fluorodeoxyuridine and methotrexate in thymidine kinase plus and thymidine kinase minus cells.
Topics: Animals; Bromodeoxyuridine; Cell Nucleus; DNA, Mitochondrial; Floxuridine; L Cells; Methotrexate; Mice; Phosphates; Thymidine; Thymidine Kinase | 1976 |
Theileria parva: purine and pyrimidine metabolism and the action of folate antagonists in parasitized bovine lymphoid cells.
Topics: Adenine; Aminopterin; Animals; Azaguanine; Cattle; Cells, Cultured; Culture Media; Eukaryota; Floxuridine; Folic Acid Antagonists; Guanine; Hypoxanthines; Lymphocytes; Methotrexate; Purines; Pyrimidine Nucleosides; Theileriasis; Thymidine; Uridine | 1977 |
Effect of methotrexate and 5-fluorodeoxyuridine on ribonucleotide reductase activity in mammalian cells.
Topics: Animals; DNA; Enzyme Induction; Floxuridine; HeLa Cells; Liver; Liver Regeneration; Male; Methotrexate; Protein Biosynthesis; Rats; Ribonucleotide Reductases; Thymine Nucleotides | 1977 |
Growth and rejection patterns of murine lymphoma cells antigenically altered following drug treatment in vivo.
Topics: Animals; Antigens, Neoplasm; Dacarbazine; DNA; Floxuridine; Graft Rejection; Leukemia, Experimental; Methotrexate; Mice; Neoplasm Transplantation; Transplantation, Homologous; Triazenes | 1978 |
Cytotoxicity of 5-fluoro-2'-deoxyuridine: requirement for reduced folate cofactors and antagonism by methotrexate.
Topics: Animals; Cells, Cultured; Floxuridine; Folic Acid; Leukemia L1210; Methotrexate | 1978 |
Thymidylate synthetase and dihydrofolic acid reductase in the stimulated human lymphocyte.
Topics: Cells, Cultured; Deoxyuridine; Floxuridine; Humans; Lectins; Lymphocytes; Methotrexate; Methyltransferases; Tetrahydrofolate Dehydrogenase; Thymidine; Thymidylate Synthase | 1978 |
Treatment of hepatic metastases with a combination of hepatic artery infusion chemotherapy and external radiotherapy.
Topics: Adult; Aged; Antineoplastic Agents; Catheterization; Cobalt Radioisotopes; Colonic Neoplasms; Female; Floxuridine; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Rectal Neoplasms | 1978 |
The regulation of thymidylate biosynthesis in Novikoff hepatoma cells and the effects of amethopterin, 5-fluorodeoxyuridine, and 3-deazauridine.
Topics: 3-Deazauridine; Animals; Cell Line; DNA, Neoplasm; Floxuridine; Liver Neoplasms, Experimental; Methotrexate; Thymidine; Thymidine Monophosphate; Thymine Nucleotides; Uridine | 1978 |
Comparison of thymidine, fluorodeoxyuridine, hydroxyurea, and methotrexate blocking at the G1/S phase transition of the cell cycle, studied by replication patterns.
Topics: Amniotic Fluid; Cell Cycle; Cells, Cultured; Chromosomes, Human; DNA Replication; Floxuridine; History, 16th Century; Humans; Hydroxyurea; Interphase; Methotrexate; Skin; Thymidine | 1978 |
Stimulation of human chorionic gonadotropin by JAr line choriocarcinoma after inhibition of DNA synthesis.
Topics: Cell Line; Choriocarcinoma; Chorionic Gonadotropin; Cycloheximide; Cytarabine; DNA, Neoplasm; Dose-Response Relationship, Drug; Female; Floxuridine; Humans; Hydroxyurea; Methotrexate; Neoplasm Proteins; Neoplasms, Experimental; Pregnancy; Uterine Neoplasms | 1979 |
Role of thymidylate synthetase activity in development of methotrexate cytotoxicity.
Topics: Animals; Cell Division; Cells, Cultured; Floxuridine; Humans; Hypoxanthines; Leucovorin; Leukemia, Experimental; Methotrexate; Methyltransferases; Mice; Thymidine; Thymidylate Synthase | 1979 |
Current status of regional arterial infusion chemotherapy.
Topics: Adenocarcinoma; Antineoplastic Agents; Carcinoma, Hepatocellular; Carotid Arteries; Catheterization; Chemotherapy, Cancer, Regional Perfusion; Floxuridine; Fluorouracil; Head and Neck Neoplasms; Hepatic Artery; Humans; Liver Neoplasms; Melanoma; Methotrexate; Mouth Neoplasms; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Neoplasms; Temporal Arteries; Time Factors | 1975 |
Enzyme pattern directed chemotherapy. The effects of combinations of methotrexate, 5-fluorodeoxyuridine and thymidine on rat hepatoma cells in vitro.
Topics: Animals; Carcinoma, Hepatocellular; Cell Division; Cell Line; Depression, Chemical; Floxuridine; Liver Neoplasms; Methotrexate; Rats; Thymidine; Time Factors | 1976 |
Treatment of primary liver cancer: response to regional chemotherapy.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Carcinoma, Hepatocellular; Chemotherapy, Cancer, Regional Perfusion; Doxorubicin; Female; Floxuridine; Fluorouracil; Hepatectomy; Humans; Liver Neoplasms; Male; Methotrexate; Middle Aged; Prognosis | 1979 |
Characteristics of association of oleoyl derivatives of 5-fluorodeoxyuridine and methotrexate with low-density lipoproteins (LDL).
Topics: Drug Carriers; Electrophoresis, Agar Gel; Floxuridine; Humans; Lipoproteins, LDL; Methotrexate; Oleic Acid; Oleic Acids; Prodrugs; Serum Albumin; Ultracentrifugation | 1992 |
Nucleoside transport-deficient mutants of PK-15 pig kidney cell line.
Topics: Animals; Biological Transport; Carrier Proteins; Cell Division; Cell Line; Clone Cells; Cytarabine; DNA; Escherichia coli; Flow Cytometry; Floxuridine; Hypoxanthine; Hypoxanthines; Kidney; Kinetics; Membrane Proteins; Methotrexate; Mutation; Nucleoside Transport Proteins; Nucleosides; Plasmids; Recombinant Proteins; Swine; Thymidine; Transfection; Tubercidin; Uridine | 1992 |
Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules.
Topics: Cell Line; Cell Survival; Colonic Neoplasms; Drug Resistance; Floxuridine; Fluorouracil; Humans; Kinetics; Methotrexate; Pteroylpolyglutamic Acids; Pyrimidines; RNA, Neoplasm; Thymidylate Synthase; Time Factors | 1992 |
Interleukin-6 and 12-O-tetradecanoyl phorbol-13-acetate act synergistically in inducing cell-cell separation and migration of human breast carcinoma cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Antibodies, Monoclonal; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Cell Line; Cell Movement; Cytokines; DNA Replication; Drug Synergism; Female; Floxuridine; Growth Substances; Humans; Interleukin-6; Methotrexate; Protein Kinase C; Recombinant Proteins; Second Messenger Systems; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Stimulation of dihydrofolate reductase promoter activity by antimetabolic drugs.
Topics: Animals; Aphidicolin; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Floxuridine; Gene Expression; Hydroxyurea; In Vitro Techniques; Methotrexate; Promoter Regions, Genetic; Tetrahydrofolate Dehydrogenase; Transcription, Genetic; Transfection | 1991 |
A comparison of the effects of antitumor agents upon normal human epidermal keratinocytes and human squamous cell carcinoma.
Topics: Carcinoma, Squamous Cell; Cell Division; Cell Line; DNA; DNA, Neoplasm; Floxuridine; Humans; Keratinocytes; Methotrexate; Skin Neoplasms; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 1990 |
Modulation of fluoropyrimidines by pretreatment with antifolates or folinic acid (leucovorin).
Topics: Antineoplastic Combined Chemotherapy Protocols; Drug Synergism; Floxuridine; Fluorouracil; Humans; Leucovorin; Methotrexate; Neoplasms | 1990 |
Prolonged serum half-life of antineoplastic drugs by incorporation into the low density lipoprotein.
Topics: Animals; Antineoplastic Agents; Chemistry, Pharmaceutical; Chromatography, Gel; Drug Carriers; Floxuridine; Half-Life; Lipoproteins, LDL; Liver; Male; Methotrexate; Rats; Ultracentrifugation | 1990 |
Enhanced inhibition of thymidylate synthase by methotrexate polyglutamates.
Topics: Breast Neoplasms; Cell Line; Female; Floxuridine; Humans; Kinetics; Macromolecular Substances; Mathematics; Methotrexate; Methyltransferases; Peptides; Polyglutamic Acid; Thymidylate Synthase | 1985 |
Synthesis and retention of methotrexate polyglutamates in Ehrlich ascites carcinoma cells.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Line; Drug Resistance; Floxuridine; Half-Life; Methotrexate; Mice; Peptides; Polyglutamic Acid | 1986 |
Evidence for direct inhibition of de novo purine synthesis in human MCF-7 breast cells as a principal mode of metabolic inhibition by methotrexate.
Topics: Acyltransferases; Antineoplastic Agents; Breast Neoplasms; Carbon Radioisotopes; Cell Line; Female; Floxuridine; Folic Acid; Glycine; Humans; Hydroxymethyl and Formyl Transferases; Kinetics; Methotrexate; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Polyglutamic Acid; Purines; Quinazolines; Trimetrexate | 1987 |
Increased growth inhibition and DNA lesions in human colon adenocarcinoma cells treated with methotrexate or 5-fluorodeoxyuridine followed by calmodulin inhibitors.
Topics: Adenocarcinoma; Bleomycin; Calmodulin; Cell Survival; Colonic Neoplasms; DNA Damage; Floxuridine; Humans; Methotrexate; Phenothiazines; Promethazine; Sulfonamides; Tumor Cells, Cultured | 1988 |
5-Fluoropyrimidine-induced DNA damage in human colon adenocarcinoma and its augmentation by the nucleoside transport inhibitor dipyridamole.
Topics: Adenocarcinoma; Colonic Neoplasms; Dipyridamole; DNA; DNA Damage; Floxuridine; Fluorouracil; Humans; Methotrexate; Nucleosides; Tumor Cells, Cultured | 1989 |
[Two cases of gastrointestinal cancers with major responses to sequential methotrexate 5-FU plus 5'-DFUR].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carcinoembryonic Antigen; Colonic Neoplasms; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Lymphatic Metastasis; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Remission Induction; Stomach Neoplasms | 1989 |
MTX-5-FU combination therapy compared to FUDR monotherapy in nude mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Methotrexate; Mice; Mice, Nude; Neoplasm Transplantation; Transplantation, Heterologous | 1989 |
Sequence-dependent enhancement of HCT-8 cell kill by trimetrexate and fluoropyrimidines: implications for the mechanism of this interaction.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Colony-Forming Units Assay; Drug Interactions; Drug Synergism; Floxuridine; Fluorouracil; Folic Acid Antagonists; Humans; Methotrexate; Quinazolines; Trimetrexate; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1989 |
Folate-pool interconversions and inhibition of biosynthetic processes after exposure of L1210 leukemia cells to antifolates. Experimental and network thermodynamic analyses of the role of dihydrofolate polyglutamylates in antifolate action in cells.
Topics: Animals; Computer Simulation; Deoxyuridine; Floxuridine; Folic Acid; Folic Acid Antagonists; Formates; Leukemia L1210; Methotrexate; Mice; Purines; Pyrimidines; Quinazolines; Tetrahydrofolates; Thermodynamics; Thymidylate Synthase; Trimetrexate | 1989 |
Interaction of 5'-deoxy-5-fluorouridine and methotrexate. A basis for reduced methotrexate toxicity.
Topics: Animals; Blood Cell Count; Body Weight; Floxuridine; Ileal Diseases; Ileum; Male; Methotrexate; Mice | 1989 |
Vestigial mutants of Drosophila melanogaster live better in the presence of aminopterin: increased level of dihydrofolate reductase in a mutant.
Topics: Aminopterin; Animals; Drosophila melanogaster; Floxuridine; Methotrexate; Phenotype; Purine Nucleotides; Pyrimidine Nucleotides; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 1989 |
Overexpression of DNA replication and repair enzymes in cisplatin-resistant human colon carcinoma HCT8 cells and circumvention by azidothymidine.
Topics: Cell Line; Cisplatin; Colonic Neoplasms; DNA Polymerase I; DNA Polymerase II; DNA Repair; DNA Replication; Drug Resistance; Etoposide; Floxuridine; Fluorouracil; Humans; Methotrexate; Tetrahydrofolate Dehydrogenase; Thymidine Kinase; Thymidylate Synthase; Tumor Cells, Cultured; Zidovudine | 1989 |
1-beta-D-arabinofuranosylcytosine enhancement of resistance to several antineoplastic drugs in mammalian tissue culture cells.
Topics: Animals; Antimetabolites, Antineoplastic; Aspartate Carbamoyltransferase; Aspartic Acid; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Cell Line; Cricetinae; Cytarabine; Dihydroorotase; Dose-Response Relationship, Drug; Drug Resistance; Floxuridine; Gene Amplification; Methotrexate; Multienzyme Complexes; Phosphonoacetic Acid; Time Factors; Vincristine | 1989 |
Agents which decrease intracellular thymidine pools cause an augmentation in human natural killer activity in vitro.
Topics: Dactinomycin; Floxuridine; Glucosamine; Humans; Interferons; Killer Cells, Natural; Methotrexate; Thymidine; Thymidine Monophosphate | 1985 |
The most common fragile site in man is 3p14.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Chromosome Aberrations; Chromosome Banding; Chromosome Fragile Sites; Chromosome Fragility; Chromosomes, Human, 1-3; Female; Floxuridine; Humans; Infant; Karyotyping; Male; Methotrexate; Middle Aged; Pedigree | 1986 |
DNA lesions in human neoplastic cells and cytotoxicity of 5-fluoropyrimidines.
Topics: Aphidicolin; Cell Survival; Centrifugation, Density Gradient; Diterpenes; DNA, Neoplasm; Floxuridine; Fluorouracil; Humans; Methotrexate; Neoplasms; Time Factors | 1986 |
Enhancement of the effects of 5-fluorouracil.
Topics: Antineoplastic Combined Chemotherapy Protocols; Drug Evaluation; Drug Synergism; Floxuridine; Fluorouracil; Humans; Methotrexate; Neoplasms; Pyrimidines | 1986 |
Comparison of the inhibitory effects of hydroxyurea, 5-fluorodeoxyuridine, 3,4-dihydroxybenzylamine, and methotrexate on human squamous cell carcinoma.
Topics: Animals; Carcinoma, Squamous Cell; Cell Line; Deoxyuracil Nucleotides; Depression, Chemical; DNA Replication; Dopamine; Floxuridine; Humans; Hydroxyurea; Leukemia L1210; Melanoma, Experimental; Methotrexate; Neoplasm Proteins; Thymidylate Synthase | 1987 |
Hepatitis in patients receiving intraarterial chemotherapy for metastatic colorectal carcinoma.
Topics: Bilirubin; Carcinoma; Chemical and Drug Induced Liver Injury; Colonic Neoplasms; Female; Floxuridine; Hepatic Artery; Hepatitis; Humans; Infusions, Intra-Arterial; Male; Methotrexate; Middle Aged; Rectal Neoplasms; Transaminases | 1987 |
[Combination chemotherapy with 3 or 4 drugs on human breast and gastrointestinal cancer xenografts in nude mice (II)].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Colonic Neoplasms; Cyclophosphamide; Doxorubicin; Female; Floxuridine; Fluorouracil; Humans; Methotrexate; Mice; Mice, Nude; Mitomycin; Mitomycins; Neoplasm Transplantation; Stomach Neoplasms; Tegafur; Vindesine | 1987 |
Prenatal diagnosis of the fragile X using thymidine induction.
Topics: Adult; Amniocentesis; Australia; Chorionic Villi; Female; Floxuridine; Fragile X Syndrome; Humans; Male; Methotrexate; Pregnancy; Prenatal Diagnosis; Sex Chromosome Aberrations; Thymidine | 1987 |
Inhibition of thymidylate synthase in intact L1210 cells by ara-C, daunomycin, hydroxyurea and 3,4-dihydroxybenzylamine.
Topics: Animals; Cytarabine; Daunorubicin; Deoxyuridine; DNA; Dopamine; Floxuridine; Hydroxyurea; Kinetics; Leukemia L1210; Methotrexate; Thymidylate Synthase | 1987 |
Transient inhibition of DNA synthesis by 5-fluorodeoxyuridine leads to overexpression of dihydrofolate reductase with increased frequency of methotrexate resistance.
Topics: Animals; Cell Cycle; Cell Line; DNA Replication; Drug Resistance; Floxuridine; Gene Amplification; Gene Expression Regulation; Leukemia L1210; Methotrexate; Mice; Tetrahydrofolate Dehydrogenase | 1988 |
Microinjected deoxynucleotides for the study of chemical inhibition of DNA synthesis.
Topics: Animals; Aphidicolin; Autoradiography; Cell Nucleus; Cells, Cultured; Cytarabine; Deoxyribonucleotides; Diterpenes; DNA Replication; Floxuridine; Hydroxyurea; Kinetics; Methotrexate; Trifluridine; Tritium | 1988 |
[Rationale and current results of loco-regional chemotherapy in hepatic metastases of colorectal carcinoma].
Topics: Antineoplastic Agents; Carmustine; Cisplatin; Colorectal Neoplasms; Doxorubicin; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Methotrexate; Mitomycin; Mitomycins; Models, Biological; Prognosis | 1987 |
Therapy for metastatic colorectal cancer with hepatic artery infusion chemotherapy using a subcutaneous implanted pump.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Colonic Neoplasms; Drug Administration Schedule; Female; Floxuridine; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Methotrexate; Middle Aged; Mitomycins; Peptic Ulcer; Prostheses and Implants; Rectal Neoplasms | 1985 |
[New developments in chemotherapy for experimental brain metastasis].
Topics: Animals; Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Daunorubicin; Doxorubicin; Floxuridine; Hydantoins; Leukemia, Myeloid; Liver Neoplasms, Experimental; Lomustine; Meningeal Neoplasms; Methotrexate; Neoplasm Transplantation; Nimustine; Nitrogen Mustard Compounds; Nitrosourea Compounds; Procarbazine; Rats | 1985 |
Defective facilitated diffusion of nucleosides, a primary mechanism of resistance to 5-fluoro-2'-deoxyuridine in the HCT-8 human carcinoma line.
Topics: Adenocarcinoma; Biological Transport; Cell Line; Colonic Neoplasms; Diffusion; Drug Resistance; Floxuridine; Humans; Methotrexate; Nucleosides; Sucrose; Thioinosine | 1985 |
Highly selective drug combinations for human colon cancer cells resistant in vitro to 5-fluoro-2'-deoxyuridine.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Biological Transport; Cell Line; Colonic Neoplasms; Drug Resistance; Floxuridine; Humans; Hypoxanthine; Hypoxanthines; Methotrexate; Nucleosides; Quinazolines; Thymidine | 1985 |
Folic acid sensitive fragile sites are not limited to the human karyotype. Demonstration of nonrandom gaps and breaks in the Persian vole Ellobius lutescens Th. inducible by methotrexate, fluorodeoxyuridine, and aphidicolin.
Topics: Animals; Aphidicolin; Arvicolinae; Chromosome Aberrations; Chromosome Fragile Sites; Chromosome Fragility; Diterpenes; Female; Floxuridine; Folic Acid; Humans; Karyotyping; Male; Methotrexate; Species Specificity | 1985 |
Rapid determination of thymidylate synthase activity and its inhibition in intact L1210 leukemia cells in vitro.
Topics: Animals; Cells, Cultured; Deoxycytidine; Deoxyuridine; Dose-Response Relationship, Drug; Floxuridine; Leukemia L1210; Methotrexate; Methyltransferases; Mice; Thymidylate Synthase; Tritium | 1985 |
Systemic chemotherapy of mammary carcinoma.
Topics: Amines; Antineoplastic Agents; Azirines; Azo Compounds; Breast Neoplasms; Caproates; Carbohydrates; Chlorambucil; Cyclophosphamide; Evaluation Studies as Topic; Floxuridine; Fluorouracil; Humans; Imidazoles; Mercaptopurine; Methotrexate; Mitomycins; Palliative Care; Prednisone; Triazines; Vincristine | 1971 |
Intra-arterial infusion--an adjuvant to the treatment of oral carcinoma.
Topics: Adult; Aged; Carotid Artery, External; Catheterization; Evaluation Studies as Topic; Floxuridine; Fluorouracil; Gingival Neoplasms; Humans; Injections, Intra-Arterial; Leucovorin; Lip Neoplasms; Methotrexate; Middle Aged; Mouth Neoplasms; Palatal Neoplasms; Palliative Care | 1972 |
The treatment of hepatic metastases by long-term chemotherapeutic infusions.
Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Colonic Neoplasms; Evaluation Studies as Topic; Female; Floxuridine; Fluorouracil; Humans; Infusions, Parenteral; Liver Neoplasms; Male; Methods; Methotrexate; Middle Aged; Neoplasm Metastasis; Rectal Neoplasms | 1970 |
[Treatment of inoperable tumors by continuous and prolonged arterial perfusion of an antimitotic association].
Topics: Antineoplastic Agents; Catheterization; Chemotherapy, Cancer, Regional Perfusion; Floxuridine; Fluorouracil; Humans; Methotrexate; Mitomycins; Neoplasms; Palliative Care; Perfusion; Vinblastine; Vincristine | 1969 |
Inhibition of plaque formation by myxoma and fibroma viruses with pyrimidine analogues.
Topics: Antiviral Agents; Benzimidazoles; Bromodeoxyuridine; Culture Techniques; Cytosine; DNA, Viral; Fibroma; Floxuridine; Fluorouracil; Idoxuridine; Mercaptopurine; Methotrexate; Myxoma virus; Nucleosides; Oncogenic Viruses; Thiosemicarbazones; Thymine | 1965 |
[A new treatment of hepatic metastases].
Topics: Chemotherapy, Cancer, Regional Perfusion; Floxuridine; Humans; Injections, Intra-Arterial; Liver Neoplasms; Methotrexate | 1966 |
Formal discussion: future prospects in leukemia chemotherapy.
Topics: Animals; Dactinomycin; Floxuridine; Leukemia; Melphalan; Mercaptopurine; Methotrexate; Mitomycins; Neoplasm Metastasis; Pyrimidines; Sarcoma, Experimental; Thiotepa | 1965 |
Studies on thymidine kinase of human liver cells in culture.
Topics: Culture Techniques; Enzyme Repression; Floxuridine; Humans; Liver; Methotrexate; Thymidine; Thymidine Kinase | 1966 |
Inhibition of cell division and cell elongation in higher plants by inhibitors of DNA synthesis.
Topics: Cell Division; DNA; Floxuridine; Gibberellins; In Vitro Techniques; Methotrexate; Mitomycins; Plants, Edible; Thymidine | 1965 |
Chemotherapy studies in an animal tumor spectrum. II. Sensitivity of tumors to fourteen antitumor chemicals.
Topics: Animals; Antineoplastic Agents; Arsenicals; Busulfan; Cyclophosphamide; Dactinomycin; Diethylstilbestrol; Floxuridine; Fluorouracil; Hydrocortisone; Mercaptopurine; Methotrexate; Mice; Mitomycins; Neoplasms, Experimental; Urethane; Vinblastine | 1966 |
Myeloid leukemia C-1498 as a screen for cancer chemotherapeutic agents.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Azaguanine; Azaserine; Busulfan; Cyclophosphamide; Dactinomycin; Female; Floxuridine; Fluorouracil; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice; Neoplasms, Experimental; Prednisone; Pyrazoles; Pyrimidines; Triethylenemelamine; Vinblastine; Vincristine | 1966 |
The action of cytostatic agents on the chromosomes of human leukocytes in vitro (preliminary communication).
Topics: Alkylating Agents; Antineoplastic Agents; Azirines; Chromosomes; Cyclophosphamide; Floxuridine; In Vitro Techniques; Leukocytes; Methotrexate; Thiotepa; Triethylenemelamine | 1966 |
An evaluation of 51 patients with hepatic artery infusion.
Topics: Antineoplastic Agents; Catheterization; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Hepatic Artery; Humans; Injections, Intra-Arterial; Liver Neoplasms; Melphalan; Methotrexate; Neoplasm Metastasis | 1966 |
The effect of treatment with cytotoxic agents on mouse spleen dihydrofolate reductase activity.
Topics: Animals; Cyclophosphamide; Floxuridine; Folic Acid; In Vitro Techniques; Leucovorin; Male; Methotrexate; Mice; Nucleosides; Organ Size; Spleen; Tetrahydrofolate Dehydrogenase; Thymidine | 1967 |
Increased growth of tumor isotransplants after immunosuppression of the recipient mice by methotrexate or 5-fluoro-2'-deoxyuridine.
Topics: Animals; Fibrosarcoma; Floxuridine; Methotrexate; Mice; Neoplasm Transplantation; Neoplasms, Multiple Primary; Sarcoma, Experimental; Transplantation Immunology; Transplantation, Autologous | 1967 |
Immunosuppression by pyrimidine nucleoside analogs.
Topics: Animals; Antibody Formation; Antimetabolites; Azathioprine; Bromodeoxyuridine; Chloramphenicol; Cytarabine; Cytosine Nucleotides; Erythrocytes; Floxuridine; Hemagglutination Tests; Idoxuridine; Injections, Intraperitoneal; Injections, Subcutaneous; Mercaptoethanol; Mercaptopurine; Methotrexate; Mice; Nucleosides; Sheep | 1966 |
The response in vitro, of continuous cultures of human lymphoblasts (CCRF-CEM cells) to chemotherapeutic agents.
Topics: Animals; Azaserine; Chloramphenicol; Culture Media; Culture Techniques; Cyclophosphamide; Cytarabine; Dactinomycin; Deoxyuridine; Floxuridine; Fluorouracil; Humans; Hydrocortisone; Lymphocytes; Mechlorethamine; Mercaptopurine; Methotrexate; Mitomycins; Puromycin; Thymidine; Triazines; Vincristine | 1967 |
New concepts in chemotherapy of advanced gastrointestinal cancer.
Topics: Aged; Cyclophosphamide; Female; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Humans; Male; Methotrexate; Middle Aged | 1967 |
Relations among cell growth, DNA synthesis, and gibberellin action.
Topics: Carbon Isotopes; Chloramphenicol; Dactinomycin; DNA; Ethanol; Floxuridine; Gibberellins; Methotrexate; Mitomycins; Plants, Edible; Puromycin; RNA; Thymidine; Tritium; Uridine | 1967 |
[Experience with non-surgical treatment of brain tumors at the authors' department].
Topics: Adenoma, Chromophobe; Adolescent; Adult; Aged; Brain Neoplasms; Child; Child, Preschool; Cobalt Isotopes; Female; Floxuridine; Folic Acid; Glioma; Humans; Infusions, Parenteral; Leucovorin; Male; Methotrexate; Middle Aged; Radioisotope Teletherapy | 1967 |
[On the inhibition of lambda phage production in nutrient broth].
Topics: Coliphages; Culture Media; Escherichia coli; Floxuridine; Methotrexate | 1966 |
Increase of dihydrofolate reductase activity in cultured mammalian cells after exposure to methotrexate.
Topics: Culture Techniques; Cycloheximide; Dactinomycin; Floxuridine; Humans; Leucine; Leukemia, Myeloid; Lymphocytes; Methotrexate; Neoplasm Proteins; Nucleosides; Puromycin; RNA, Neoplasm; Tetrahydrofolate Dehydrogenase; Tritium | 1967 |
Effect of folinate on thymidine uptake by Pediococcus cerevisiae.
Topics: Aminopterin; Carbon Isotopes; Deoxyuridine; Floxuridine; Glucose; Hydrogen-Ion Concentration; Iodoacetates; Leucovorin; Methotrexate; Pediococcus; Temperature; Thymidine; Thymine; Tritium; Uracil | 1968 |
Determination of certain antitumor agents in mouse blood by microbiologic assay.
Topics: Anilides; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Biological Assay; Floxuridine; Fluorouracil; Mercaptopurine; Methods; Methotrexate; Mice | 1968 |
[Mutation to inhibitor-resistance and backward mutation to inhibitor-sensitivity in cancer cell cultures].
Topics: Animals; Culture Media; Culture Techniques; Floxuridine; Glycine; Hypoxanthines; Mast-Cell Sarcoma; Methotrexate; Mice; Mutation; Neoplasm Transplantation; Thymidine | 1967 |
Radiosensitization of brain tumor cells with a thymidine analogue (bromouridine).
Topics: Astrocytoma; Brain Neoplasms; Bromodeoxyuridine; Culture Techniques; DNA; Floxuridine; Fluorouracil; Follow-Up Studies; Glioma; Humans; Meningioma; Methotrexate; Oligodendroglioma; Radiation-Sensitizing Agents; Thymidine | 1968 |
[On the effect of cytostatic agents on human chromosomes].
Topics: Antineoplastic Agents; Chromosomes; Cytogenetics; Floxuridine; Humans; Hydrazines; Leukemia, Myeloid; Leukocytes; Methotrexate; Thiotepa; Triaziquone; Triethylenemelamine | 1968 |
Responses of freshly cultured tumour cells to certain selected chemotherapeutic agents.
Topics: Adenocarcinoma; Antineoplastic Agents; Chlorambucil; Colchicine; Culture Techniques; Cyclophosphamide; Dactinomycin; Female; Floxuridine; Fluorouracil; Hodgkin Disease; Humans; Melphalan; Mercaptopurine; Methotrexate; Nandrolone; Neoplasms; Nitrogen Mustard Compounds; Norethindrone; Prednisolone; Progesterone; Testosterone; Thiotepa; Uterine Neoplasms; Vinblastine | 1968 |
[Chemotherapeutic treatment of liver metastases as a function of their spontaneous evolution].
Topics: Floxuridine; Humans; Liver Neoplasms; Methotrexate; Neoplasm Metastasis | 1969 |
Protracted intra-arterial chemotherapy with sequential courses of antimitotics and hydrogen peroxyde in the treatment of head and neck tumors.
Topics: Antineoplastic Agents; Catheterization; Floxuridine; Fluorouracil; Head and Neck Neoplasms; Humans; Hydrogen Peroxide; Injections, Intra-Arterial; Methods; Methotrexate; Mitomycins; Mitosis; Mouth Neoplasms; Nitrogen Mustard Compounds; Oxygen Inhalation Therapy; Perfusion; Stimulation, Chemical | 1969 |
Studies on in vitro lymphocyte proliferation in cultures synchronized by the inhibition of DNA synthesis. I. Variability of S plus G2 periods of first generation cells.
Topics: Benzocycloheptenes; Chromosomes; Culture Media; Culture Techniques; DNA; Floxuridine; Humans; Kinetics; Lectins; Lymphocytes; Methotrexate; Mitosis; Nucleosides; Thymidine; Time Factors; Tritium | 1969 |
[A proof of the entrance of cells into the period of DNA synthesis under the effects of 5-fuoro-2'-desoxyuridine and amethopterin].
Topics: Animals; Autoradiography; Cricetinae; Culture Techniques; Cytosine Nucleotides; DNA; Floxuridine; Methotrexate; Mitosis; Thymidine; Tritium | 1968 |
Distribution of DNA replicator sites in mammalian nuclei after different methods of cell synchronization.
Topics: Animals; Autoradiography; Cell Line; Cell Nucleus; Cricetinae; Culture Techniques; DNA; DNA Replication; Female; Fibroblasts; Floxuridine; Methods; Methotrexate; Microscopy, Electron; Mitosis; Ovary; Thymidine; Tritium | 1970 |
[Utilization of amethopterin and floxuridine by intra-arterial infusion in treatment of head and neck tumors].
Topics: Drug Synergism; Floxuridine; Head and Neck Neoplasms; Humans; Injections, Intra-Arterial; Methotrexate; Mouth Neoplasms | 1970 |
Absence of an effect of amethopterin and 5-fluorodeoxyuridine upon levels of thymidine triphosphate in HeLa cells.
Topics: Chromatography, Ion Exchange; Chromatography, Paper; Cytosine Nucleotides; Deoxyribonucleotides; Depression, Chemical; DNA, Neoplasm; Floxuridine; HeLa Cells; Humans; In Vitro Techniques; Methotrexate; Thymine Nucleotides | 1971 |
Mathematical simulation in chemotherapy.
Topics: Cell Membrane Permeability; Cytarabine; DNA, Neoplasm; Drug Interactions; Feedback; Floxuridine; Isoquinolines; Kinetics; Methotrexate; Models, Theoretical; Protein Binding; Thiosemicarbazones | 1971 |
Distribution of DNA replicator sites in mammalian nuclei. II. Effects of prolonged inhibition of DNA synthesis.
Topics: Adenosine; Animals; Autoradiography; Cell Line; Cell Nucleolus; Cell Nucleus; Cell Survival; Chromatin; Cricetinae; DNA; DNA Replication; Female; Floxuridine; Lung; Methotrexate; Microscopy, Electron; Mitosis; Ovary; Rodentia; Sex Chromatin; Thymidine; Time Factors; Tritium | 1972 |
Interaction of drugs inhibiting different steps in the synthesis of DNA.
Topics: Animals; Cells, Cultured; Cytarabine; Depression, Chemical; DNA, Neoplasm; Drug Antagonism; Drug Interactions; Drug Synergism; Feedback; Floxuridine; In Vitro Techniques; Isoquinolines; Leukemia L1210; Methotrexate; Mice; Models, Biological; Thiosemicarbazones | 1972 |
Mode of action of methotrexate upon insulin-antibody formation in guinea pigs.
Topics: Adenosine; Animals; Antibody Formation; Deoxyadenosines; Depression, Chemical; Drug Antagonism; Floxuridine; Formates; Guanosine; Guinea Pigs; Immunization; Immunosuppressive Agents; Insulin Antibodies; Iodine Isotopes; Leucovorin; Male; Mathematics; Methotrexate; Swine; Tetrahydrofolates; Thymidine; Time Factors | 1972 |
Regulation of thymidylate synthetase activity in cultured mammalian cells.
Topics: Animals; Cell Division; Cells, Cultured; Cricetinae; Dactinomycin; Floxuridine; Methotrexate; Methylation; Protein Biosynthesis; Puromycin; Radiometry; RNA; Thymidine Kinase; Thymine Nucleotides; Transferases; Tritium; Uracil Nucleotides | 1972 |
Practical aspects of investigation and treatment of colorectal cancer.
Topics: Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Infusions, Parenteral; Liver Function Tests; Liver Neoplasms; Lymphatic Metastasis; Male; Methotrexate; Neoplasm Metastasis; Proctoscopy; Prognosis; Rectal Neoplasms; Sex Factors | 1972 |
Changes in sarcoma 180 cells associated with drug-induced resistance to adenosine analogs.
Topics: Adenosine; Alkenes; Aminohydrolases; Animals; Carbon Isotopes; Cell Division; Cells, Cultured; Chromatography, Paper; Cross Reactions; Deamination; Drug Resistance; Floxuridine; Furans; Inosine; Methotrexate; Mice; Pentosyltransferases; Phosphotransferases; Purines; Ribonucleosides; Sarcoma 180; Time Factors | 1972 |
Comparison of the effects of several inhibitors of the synthesis of nucleic acids upon the viability and progression through the cell cycle of cultured H. Ep. no. 2 cells.
Topics: Antimetabolites; Azaguanine; Carcinoma; Cell Division; Cell Line; Cell Survival; Cytarabine; DNA Replication; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Humans; Hydroxyurea; Laryngeal Neoplasms; Mercaptopurine; Methotrexate; Mitosis; Ribonucleosides; Thioguanine; Time Factors; Tritium | 1972 |
Combinations of drugs which interact as inhibitors of DNA biosynthesis.
Topics: Adenine; Animals; Antineoplastic Agents; Arabinose; Cytosine; DNA, Neoplasm; Drug Interactions; Floxuridine; Methotrexate; Mice | 1972 |
Initiation and continuation of DNA replication are not associated with the nuclear envelope in mammalian cells.
Topics: Animals; Cell Nucleus; Cells, Cultured; Cricetinae; Cytosine Nucleotides; DNA Replication; Female; Floxuridine; Membranes; Methotrexate; Microscopy, Electron; Ovary; Thymidine; Tritium | 1973 |
Regional arterial chemotherapy for advanced carcinoma of the head and neck. A ten-year review.
Topics: Antimetabolites; Antineoplastic Agents; Carotid Arteries; Catheterization; Digestive System; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Head; Head and Neck Neoplasms; Humans; Infusions, Parenteral; Methotrexate; Neoplasms; Remission, Spontaneous | 1973 |
Studies with a mathematical model of folate metabolism.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Floxuridine; Folic Acid; Formates; Glycine; Hydrolases; Kinetics; Leukemia L1210; Mathematics; Methotrexate; Models, Biological; Oxidoreductases; Pentosephosphates; Purines; Serine; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thymidylate Synthase; Time Factors; Transferases | 1973 |
Isotope-dilution analysis of rate-limiting steps and pools affecting the incorporation of thymidine and deoxycytidine into cultured thymus cells.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Cells, Cultured; Culture Media; Cytidine; Deoxycytidine; Deoxyribonucleosides; Floxuridine; Isotope Labeling; Kinetics; Methotrexate; Rats; Thymidine; Thymidylate Synthase; Thymus Gland; Time Factors; Tritium | 1974 |
Sensitivity of human leukemic cells to anti-cancer agents in culture.
Topics: Animals; Antineoplastic Agents; Azauridine; Cells; Cells, Cultured; Chlorambucil; Culture Media; Cyclophosphamide; Cytarabine; Drug Resistance; Floxuridine; Horses; Humans; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice; Prednisone; Thioguanine; Vincristine | 1974 |
Thymidylate synthetase from amethopterin-resistant Lactobacillus casei. Purification by affinity chromatography.
Topics: Aniline Compounds; Cell-Free System; Chemical Phenomena; Chemistry; Chromatography, Affinity; Drug Resistance, Microbial; Electrophoresis, Polyacrylamide Gel; Floxuridine; Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; Methods; Methotrexate; Methyltransferases; Organophosphorus Compounds; Polysaccharides; Protons; Spectrophotometry, Ultraviolet; Thymidylate Synthase | 1974 |
Effects of actinomycin D, amethopterin, and 5-fluro-2'-deoxyuridine on procentriole formation in Chinese hamster fibroblasts in culture.
Topics: Animals; Cell Division; Cell Line; Colchicine; Cricetinae; Dactinomycin; DNA; Fibroblasts; Floxuridine; Methotrexate; Microscopy, Electron; Organoids; RNA; Time Factors | 1974 |
Purification and amino acid analysis of an active site peptide from thymidylate synthetase containing covalently bound 5-fluoro-2'-deoxyuridylate and methylenetetrahydrofolate.
Topics: Amino Acid Sequence; Amino Acids; Binding Sites; Carbon Radioisotopes; Chromatography, Gel; Chromatography, Ion Exchange; Drug Resistance, Microbial; Electrophoresis, Paper; Floxuridine; Lacticaseibacillus casei; Methotrexate; Methyltransferases; Peptides; Pronase; Protein Binding; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Tetrahydrofolates; Thymidylate Synthase; Tritium; Uracil Nucleotides | 1974 |
Affinity chromatography of thymidylate synthetases using 5-fluoro-2'-deoxyuridine 5'-phosphate derivatives of sepharose.
Topics: Binding Sites; Chromatography, Affinity; Coliphages; Deuterium; Drug Resistance, Microbial; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Evaluation Studies as Topic; Floxuridine; Hydrogen-Ion Concentration; Kinetics; Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; Methods; Methotrexate; Methyltransferases; Organophosphorus Compounds; Protein Binding; Structure-Activity Relationship; Thymidylate Synthase; Uracil Nucleotides | 1974 |
Genetic and possible biochemical mechanisms in viral carcinogenesis.
Topics: Avian Sarcoma Viruses; Culture Techniques; Cytarabine; DNA; Floxuridine; Genetics; Methotrexate; Neoplasms, Experimental; Oncogenic Viruses; Radionuclide Imaging; RNA; Tritium | 1966 |
Infusion of liver tumours.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Chemotherapy, Cancer, Regional Perfusion; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Liver Neoplasms; Methotrexate; Neoplasm Metastasis; Radioisotopes | 1968 |
Transient inhibition of avian myeloblastosis virus reproduction by amethopterin and fluorodeoxyuridine.
Topics: Animals; Antiviral Agents; Avian Leukosis Virus; Cell Division; Chick Embryo; Culture Techniques; DNA, Viral; Fibroblasts; Floxuridine; Methotrexate; RNA, Viral; Thymidine; Tritium; Uridine; Virus Replication | 1967 |
[Combined drug-surgical treatment in primary and secondary liver tumors].
Topics: Carcinoma, Hepatocellular; Drug Therapy, Combination; Floxuridine; Humans; Injections, Intra-Arterial; Liver Neoplasms; Methotrexate; Neoplasm Metastasis; Postoperative Complications; Prognosis; Vincristine | 1974 |
5-fluorouracil-methotrexate synergy: enhancement of 5-fluorodeoxyridylate binding to thymidylate synthase by dihydropteroylpolyglutamates.
Topics: Animals; Cell Survival; Drug Synergism; Floxuridine; Fluorouracil; Folic Acid; Leukemia L1210; Methotrexate; Methyltransferases; Polyglutamic Acid; Protein Binding; Pteroylpolyglutamic Acids; Thymidylate Synthase | 1980 |
Biochemical alterations during unperturbed suspension growth of L1210 cells.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Cycle; DNA, Neoplasm; Floxuridine; Leukemia L1210; Methotrexate; Mice; Neoplasm Proteins; Phosphoribosyl Pyrophosphate; Ribonucleotides; RNA, Neoplasm | 1981 |
Fragile X expression suppressed in either FUdR or methotrexate treated fibroblasts by pretreatment with 5-azacytidine.
Topics: Azacitidine; Chromosome Fragility; Drug Interactions; Female; Fibroblasts; Floxuridine; Gene Expression Regulation; Humans; Male; Methotrexate; X Chromosome | 1984 |
Genetic and biochemical consequences of thymidylate stress.
Topics: Chromosome Aberrations; DNA Repair; DNA, Fungal; DNA, Mitochondrial; Ethyl Methanesulfonate; Floxuridine; Methotrexate; Methylnitronitrosoguanidine; Models, Biological; Mutation; Recombination, Genetic; Saccharomyces cerevisiae; Sister Chromatid Exchange; Sulfanilamides; Thymidine Monophosphate; Thymine Nucleotides | 1982 |
Inhibitors of DNA precursor metabolism in Dictyostelium discoideum.
Topics: Aminopterin; Antimetabolites; Dictyostelium; DNA; Floxuridine; Folic Acid; Hydroxyurea; Methotrexate; Time Factors; Trimethoprim | 1982 |
Selective expansion of mitochondrial nucleoside triphosphate pools in antimetabolite-treated HeLa cells.
Topics: Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyribonucleotides; DNA; Floxuridine; HeLa Cells; Humans; Methotrexate; Mitochondria; Ribonucleotides; Thymine Nucleotides | 1982 |
Thymidylate synthetase levels as a factor in 5-fluorodeoxyuridine and methotrexate cytotoxicity in gastrointestinal tumor cells.
Topics: Cells, Cultured; Floxuridine; Gastrointestinal Neoplasms; Humans; Methotrexate; Methyltransferases; Neoplasms, Experimental; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 1982 |
Stability of cancer chemotherapeutic agents in a totally implanted drug delivery system.
Topics: Antineoplastic Agents; Cytarabine; Drug Stability; Floxuridine; Infusions, Parenteral; Methotrexate; Vinblastine | 1982 |
Thymidylate synthetase overproduction in 5-fluorodeoxyuridine-resistant mouse fibroblasts.
Topics: Animals; Cell Line; Clone Cells; Culture Media; Drug Resistance; Fibroblasts; Floxuridine; Gene Expression Regulation; Methotrexate; Methyltransferases; Mice; Thymidine Kinase; Thymidylate Synthase | 1982 |
Fluorodeoxyuridine synchronization of bone marrow cultures.
Topics: Bone Marrow; Chromosomes; Floxuridine; Humans; Karyotyping; Metaphase; Methotrexate; Time Factors | 1983 |
Antimitotic drugs that enhance neuronal survival in olfactory bulb cell cultures.
Topics: Animals; Bromodeoxyuridine; Cells, Cultured; Cytarabine; Depression, Chemical; Floxuridine; Hydroxyurea; Methotrexate; Mitosis; Olfactory Bulb; Potassium; Rats; Rats, Inbred Strains; Thymidine | 1983 |
Altered thymidylate synthetase in 5-fluorodeoxyuridine-resistant Ehrlich ascites carcinoma cells.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Line; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Floxuridine; Humans; Kinetics; Methotrexate; Methyltransferases; Molecular Weight; Temperature; Thymidine Kinase; Thymidylate Synthase | 1983 |
2'-deoxyribosyl analogues of UDP-N-acetylglucosamine in cells treated with methotrexate or 5-fluorodeoxyuridine.
Topics: Cell Line; Chromatography, Paper; Floxuridine; Hot Temperature; Humans; Methotrexate; Time Factors; Uridine Diphosphate N-Acetylglucosamine; Uridine Diphosphate Sugars | 1983 |
Enhancement of the incorporation of 5-fluorodeoxyuridylate into DNA of HL-60 cells by metabolic modulations.
Topics: Cell Line; Deoxyuracil Nucleotides; DNA Replication; DNA, Neoplasm; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Kinetics; Leukemia, Myeloid, Acute; Methotrexate; Thymidine; Tritium | 1983 |
Rate of DNA synthesis in exponentially growing cell lines in the presence and absence of antimetabolites.
Topics: Antimetabolites; Cell Line; DNA; Floxuridine; Methotrexate; Thymidine; Thymidylate Synthase | 1983 |
Intra-arterial infusion in tumors of the pelvis.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Floxuridine; Fluorouracil; Humans; Iliac Artery; Infusions, Intra-Arterial; Leucovorin; Male; Melanoma; Methotrexate; Middle Aged; Ovarian Neoplasms; Pelvic Neoplasms; Prostatic Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms | 1983 |
Selection and use of a method for the culture of blood leucocytes to reveal the fra(x) site.
Topics: Adult; Cells, Cultured; Child; Chromosome Fragility; Culture Media; Cytological Techniques; Female; Floxuridine; Humans; Hydrogen-Ion Concentration; Leukocytes; Male; Mental Disorders; Methotrexate; X Chromosome | 1984 |
Cytogenetic investigations in mentally retarded and normal males from 14 families with the fragile site at Xq28. Results of folic acid treatment on fra(X) expression.
Topics: Adolescent; Adult; Bromodeoxyuridine; Cells, Cultured; Child; Child, Preschool; Chromosome Fragile Sites; Chromosome Fragility; Female; Fibroblasts; Floxuridine; Folic Acid; Gene Expression Regulation; Genetic Markers; Humans; Infant; Intellectual Disability; Lymphocytes; Male; Methotrexate; Middle Aged; X Chromosome | 1984 |
The effect of induction of hemoglobin synthesis in cultured Friend cells on the number of initiation sites for replication and transcription.
Topics: Acetamides; Aminoisobutyric Acids; Animals; Cell Differentiation; Cell Line; Dimethyl Sulfoxide; DNA Replication; Floxuridine; Hemoglobins; Kinetics; Leukemia, Experimental; Methotrexate; Mice; Transcription, Genetic | 1984 |
Rate-limiting steps in the interactions of fluoropyrimidines and methotrexate.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; Deoxyuridine; DNA, Neoplasm; Drug Interactions; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Methotrexate; Mice; Neoplasm Proteins; RNA, Neoplasm; Thymidine Monophosphate | 1984 |
Methodology for the study of the effect of drugs on development and DNA replication in Drosophila melanogaster embryonic tissue.
Topics: Animals; Caffeine; Cell Membrane Permeability; Cell Nucleus; Colchicine; DNA Replication; Drosophila melanogaster; Embryo, Nonmammalian; Female; Floxuridine; Kinetics; Methotrexate; Microscopy, Electron; Oviposition; Ovum | 1984 |
Nonrandom distribution of methotrexate-induced aberrations on human chromosomes. Detection of further folic acid sensitive fragile sites.
Topics: Cells, Cultured; Chromosome Aberrations; Chromosome Banding; Chromosome Fragile Sites; Chromosome Fragility; Floxuridine; Folic Acid Deficiency; Humans; Karyotyping; Lymphocytes; Methotrexate | 1984 |
Modulation of fluoropyrimidine cytotoxicity by methotrexate or 5-methyltetrahydrofolate in human leukemia cells in vitro.
Topics: Cells, Cultured; Drug Synergism; Floxuridine; Fluorouracil; Humans; Leukemia; Methotrexate; Tetrahydrofolates | 1984 |
Pyrimidine metabolism of Bdellovibrio bacteriovorus grown intraperiplasmically and axenically.
Topics: Bdellovibrio; Escherichia coli; Floxuridine; Methotrexate; Phosphotransferases; Pyrimidines; Thymidine Kinase | 1981 |
New implantable continuous administration and bolus dose intracarotid drug delivery system for the treatment of malignant gliomas.
Topics: Adult; Animals; Antineoplastic Agents; Brain Neoplasms; Carmustine; Carotid Arteries; Chemotherapy, Cancer, Regional Perfusion; Female; Floxuridine; Glioblastoma; Humans; Macaca mulatta; Male; Methotrexate; Middle Aged | 1982 |
Interferon and sodium butyrate inhibit the stimulation of poly(ADP-ribose) synthetase in mouse cells stimulated to divide.
Topics: Animals; Butyrates; Butyric Acid; Cell Cycle; Cells, Cultured; DNA Replication; Floxuridine; Humans; Hydroxyurea; Interferon Type I; Kinetics; Methotrexate; Mice; NAD+ Nucleosidase; Poly(ADP-ribose) Polymerases | 1983 |
Biochemical mechanisms in the Killmann experiment: critique of the deoxyuridine suppression test.
Topics: Deoxyribonucleosides; Deoxyuridine; DNA; Floxuridine; Humans; In Vitro Techniques; Lymphocyte Activation; Lymphocytes; Methotrexate; Phytohemagglutinins; Thymidine; Thymidine Kinase; Thymine Nucleotides | 1980 |
The interaction between fluoropyrimidines and methotrexate, and [4C]-formate incorporation into nucleic acids and protein.
Topics: Animals; Carcinoma, Ehrlich Tumor; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Interactions; Floxuridine; Formates; In Vitro Techniques; Methotrexate; Mice; Neoplasm Proteins; RNA, Neoplasm; Tetrahydrofolates | 1980 |
Combined effects of methotrexate and 5-fluoropyrimidine on human breast cancer cells in serum-free culture.
Topics: Breast Neoplasms; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Floxuridine; Fluorouracil; Humans; Methotrexate | 1980 |
fluoropyrimidine-induced antagonism to free and tightly bound methotrexate: suppression of [14C] formate incorporation into RNA and protein.
Topics: Animals; Carbon Radioisotopes; Carcinoma, Ehrlich Tumor; Deoxyuridine; DNA, Neoplasm; Floxuridine; Formates; Methotrexate; Mice; Neoplasm Proteins; RNA, Neoplasm | 1980 |
Resistance to methotrexate in thymidylate synthetase-deficient mutants of cultured mouse mammary tumor FM3A cells.
Topics: Animals; Cell Line; Drug Resistance; Floxuridine; Mammary Neoplasms, Experimental; Methotrexate; Methyltransferases; Mice; Mutation; Tetrahydrofolates; Thymidine; Thymidine Kinase; Thymidylate Synthase | 1981 |
Relationship between chromatin structure and replication in mouse L-cells.
Topics: Animals; Chromatin; Cycloheximide; Cytarabine; DNA Replication; Floxuridine; Hydroxyurea; Isoleucine; L Cells; Methotrexate; Mice; Mitomycin; Mitomycins; Protein Biosynthesis; Structure-Activity Relationship | 1980 |
Studies on micronuclei time response and on the effects of multiple treatments of mutagens on induction of micronuclei.
Topics: Animals; Busulfan; Cell Nucleus; Colchicine; Cyclophosphamide; Cytarabine; Ethyl Methanesulfonate; Floxuridine; Male; Methotrexate; Methyl Methanesulfonate; Mice; Mitomycins; Mutagenicity Tests; Mutagens; Time Factors; Triethylenemelamine; Vincristine | 1981 |
An optimal, generalized sampling time of 30 +/- 6 h after double dosing in the mouse peripheral blood micronucleus test.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Carcinogens; Colchicine; Cyclophosphamide; Cytarabine; Floxuridine; Fluorouracil; Kinetics; Methotrexate; Mice; Mice, Inbred Strains; Micronucleus Tests; Mitomycin; Mutagens; Reticulocytes; Sulfuric Acid Esters; Time Factors | 1995 |
Lack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Base Sequence; Bone Neoplasms; Cell Division; Cell Line; Cisplatin; Doxorubicin; Drug Resistance, Neoplasm; Etoposide; Fibrosarcoma; Floxuridine; Humans; Liposarcoma; Methotrexate; Molecular Sequence Data; Oligonucleotide Probes; Osteosarcoma; Recombinant Proteins; Retinoblastoma Protein; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Transfection; Tumor Cells, Cultured | 1995 |
The vestigial locus of Drosophila melanogaster is involved in resistance to inhibitors of dTMP synthesis.
Topics: Aminopterin; Animals; Drosophila melanogaster; Drug Resistance; Floxuridine; Folic Acid Antagonists; Heterozygote; Methotrexate; Mutation; Nuclear Proteins; Phenotype; Species Specificity; Thymidine Monophosphate; Wings, Animal | 1993 |
Studies on the cross resistance of folylpolyglutamate synthetase-deficient, methotrexate-resistant CCRF-CEM human leukemia sublines.
Topics: Antineoplastic Agents; Cell Division; Cell Survival; Clone Cells; Drug Resistance; Drug Screening Assays, Antitumor; Drug Synergism; Floxuridine; Folic Acid Antagonists; Humans; Methotrexate; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured | 1993 |
Inhibitors of thymidylate synthase and dihydrofolate reductase potentiate the antiviral effect of acyclovir.
Topics: Acyclovir; Animals; Antiviral Agents; Cell Line; Cell Survival; Deoxyribonucleosides; Drug Synergism; Floxuridine; Folic Acid Antagonists; Haplorhini; Immunoenzyme Techniques; Methotrexate; Simplexvirus; Thymidylate Synthase | 1993 |
Isolation and characterization of a human ileocecal carcinoma cell line (HCT-8) subclone resistant to fluorodeoxyuridine.
Topics: Antimetabolites, Antineoplastic; Cell Division; Colonic Neoplasms; Drug Resistance; Floxuridine; Fluorouracil; Humans; Methotrexate; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidine Kinase; Thymidine Phosphorylase; Thymidylate Synthase; Tumor Cells, Cultured | 1993 |
[Usefulness of contact thermography for the evaluation of chemotherapeutic effectiveness in breast cancer].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Doxorubicin; Female; Floxuridine; Humans; Methotrexate; Middle Aged; Mitomycin; Thermography; Vindesine | 1993 |
Characteristics of cancer cell death after exposure to cytotoxic drugs in vitro.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Death; Dexamethasone; DNA, Neoplasm; Flow Cytometry; Floxuridine; Fluorouracil; Humans; Leukemia-Lymphoma, Adult T-Cell; Methotrexate; Tumor Cells, Cultured; Vincristine | 1996 |
The influence of BIBW22BS, a dipyridamole derivative, on the antiproliferative effects of 5-fluorouracil, methotrexate and gemcitabine in vitro and in human tumour xenografts.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Deoxycytidine; Dipyridamole; Doxorubicin; Drug Resistance; Female; Floxuridine; Fluorouracil; Gemcitabine; Humans; Methotrexate; Mice; Mice, Nude; Morpholines; Neoplasms; Neoplasms, Experimental; Protein Binding; Transplantation, Heterologous; Triamterene; Tumor Cells, Cultured; Vincristine | 1995 |
Intraarterial hepatic chemotherapy with fluorouracil, fluorodeoxyuridine, mitomycin C, cisplatin or methotrexate as single-agent anticancer drugs for a transplanted experimental liver tumor in rats.
Topics: Angiography; Animals; Antineoplastic Agents; Cisplatin; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Injections, Intra-Arterial; Liver Neoplasms, Experimental; Male; Methotrexate; Mitomycin; Neoplasm Transplantation; Prospective Studies; Rats; Rats, Sprague-Dawley | 1996 |
2',3'-Didehydro-3'-deoxythymidine: regulation of its metabolic activation by modulators of thymidine-5'-triphosphate biosynthesis.
Topics: Amides; Biotransformation; Biphenyl Compounds; Cell Line; Deoxyguanosine; Floxuridine; HIV; HIV Reverse Transcriptase; HIV-1; Humans; Hydroxyurea; Kinetics; Methotrexate; Models, Biological; Phosphorylation; Pyrazoles; Reverse Transcriptase Inhibitors; Ribonucleosides; Ribose; RNA-Directed DNA Polymerase; Stavudine; Thymidine Kinase; Thymine Nucleotides; Tumor Cells, Cultured | 1996 |
Biological properties of fluoroglutamate-containing analogs of folates and methotrexate with altered capacities to form poly (gamma-glutamate) metabolites.
Topics: Animals; Cell Division; Floxuridine; Folic Acid; Growth Inhibitors; Growth Substances; Humans; Leucovorin; Methotrexate; Polyglutamic Acid; Rats; Tumor Cells, Cultured | 1996 |
Overexpression of a heterologous thymidine kinase delays apoptosis induced by factor deprivation and inhibitors of deoxynucleotide metabolism.
Topics: Animals; Apoptosis; B-Lymphocytes; Cell Line; Cell Survival; Culture Media, Conditioned; Deoxyribonucleotides; Floxuridine; Herpesvirus 1, Human; Hydroxyurea; Interleukin-3; Kinetics; Methotrexate; Mice; Nucleic Acid Synthesis Inhibitors; Recombinant Proteins; Thymidine Kinase; Transfection | 1997 |
[A case of adriamycin and methotrexate-resistant recurrent breast cancer treated with doxifluridine and mitomycin C].
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Doxorubicin; Drug Resistance, Neoplasm; Female; Floxuridine; Humans; Lymphatic Metastasis; Methotrexate; Middle Aged; Mitomycin; Neoplasm Recurrence, Local | 1999 |
[A case of diffusely infiltrating carcinoma of the sigmoid colon associated with lymphangitis carcinomatosa effectively treated with sequential MTX.5-FU and 5'-DFUR].
Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Floxuridine; Fluorouracil; Humans; Lymphangitis; Male; Methotrexate; Sigmoid Neoplasms | 2000 |
The role of p53 in death of IL-3-dependent cells in response to cytotoxic drugs.
Topics: Animals; Antineoplastic Agents; Apoptosis; Bleomycin; Bone Marrow Cells; Cells, Cultured; Cisplatin; Colony-Forming Units Assay; DNA Damage; DNA Replication; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Floxuridine; Genes, p53; Hematopoietic Stem Cells; Hydroxyurea; Interleukin-3; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Knockout; Radiation Tolerance; Tumor Suppressor Protein p53 | 2000 |
Surrogate endpoints for new colorectal cancer drugs.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Leucovorin; Methotrexate; Randomized Controlled Trials as Topic; Survival Analysis | 2000 |
Role of Bax in apoptosis of IL-3-dependent cells.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Bone Marrow Cells; Caspases; Cell Line; Cell Membrane; Cell Separation; Cisplatin; Colony-Forming Units Assay; Dimerization; Enzyme Activation; Enzyme Inhibitors; Floxuridine; Gene Expression; Gene Expression Regulation; Hydroxyurea; Interleukin-3; MAP Kinase Signaling System; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Weight; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Signal Transduction | 2001 |
A comparative study of 5-fluorouracil (FU), 5-fluorodeoxyuridine (FUDR), and methotrexate (MTX)-progress report.
Topics: Antineoplastic Agents; Floxuridine; Fluorouracil; Folic Acid Antagonists; Methotrexate; Nucleosides; Nucleotides; Research Report; Uracil | 1962 |
Approaches for combined radiation and chemotherapy.
Topics: Antineoplastic Agents; DNA; DNA, Bacterial; DNA, Neoplasm; Floxuridine; Humans; Methotrexate; Neoplasms; Radiotherapy | 1963 |
CHEMOTHERAPY OF METASTATIC LIVER CANCER BY PROLONGED HEPATIC-ARTERY INFUSION.
Topics: Alkaline Phosphatase; Bile Duct Neoplasms; Bilirubin; Chemotherapy, Cancer, Regional Perfusion; Colonic Neoplasms; Erythrocyte Count; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Liver Neoplasms; Methotrexate; Neoplasm Metastasis; Pancreatic Neoplasms; Rectal Neoplasms; Stomach Neoplasms; Sulfobromophthalein; Transaminases; Uterine Cervical Neoplasms | 1964 |
CANCER CHEMOTHERAPY BY PROLONGED ARTERIAL INFUSION.
Topics: Angiography; Arm; Brachiocephalic Trunk; Brain Neoplasms; Carotid Arteries; Chemotherapy, Cancer, Regional Perfusion; Floxuridine; Fluorescent Dyes; Fluorouracil; Head and Neck Neoplasms; Hepatic Artery; Humans; Iliac Artery; Leg; Liver Neoplasms; Methotrexate; Neoplasms; Pelvic Neoplasms; Subclavian Artery; Temporal Arteries; Thoracic Neoplasms; Toxicology | 1964 |
THE ADMINISTRATION OF CHEMO-THERAPEUTIC AGENTS IN THE TREATMENT OF ADVANCED HEAD AND NECK CANCER.
Topics: Alkylating Agents; Antineoplastic Agents; Aorta; Aorta, Abdominal; Black People; Catheterization; Ethoglucid; Facial Neoplasms; Floxuridine; Head; Head and Neck Neoplasms; Humans; Injections, Intra-Arterial; Kenya; Methotrexate; Neoplasms; Nitrogen Mustard Compounds; Palliative Care; Surgical Procedures, Operative; Toxicology | 1964 |
THE CLINICAL EFFECTS OF THE CONTINUOUS INTRAVENOUS INFUSION OF CANCER CHEMOTHERAPEUTIC COMPOUNDS.
Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Antineoplastic Agents; Floxuridine; Fluorouracil; Infusions, Intravenous; Infusions, Parenteral; Methotrexate; Mitomycin; Mitomycins; Neoplasms; Thymidine | 1964 |
PROTRACTED ARTERIAL INFUSION CANCER CHEMOTHERAPY.
Topics: Adenocarcinoma; Carcinoma; Carcinoma, Squamous Cell; Carotid Arteries; Catheterization; Colonic Neoplasms; Floxuridine; Head and Neck Neoplasms; Humans; Infusions, Parenteral; Methotrexate; Neoplasms; Pelvic Neoplasms; Skull Neoplasms; Tongue Neoplasms | 1964 |
INDIVIDUALIZED CHEMOTHERAPY BY IN VITRO DRUG SELECTION.
Topics: Antineoplastic Agents; Bone Neoplasms; Dactinomycin; Female; Floxuridine; Fluorouracil; Genital Neoplasms, Female; Humans; In Vitro Techniques; Intestinal Neoplasms; Leukemia; Mechlorethamine; Melanoma; Mercaptopurine; Methotrexate; Neoplasms; Pharyngeal Neoplasms; Respiratory Tract Neoplasms; Stomach Neoplasms; Thiotepa | 1964 |
PROTRACTED AMBULATORY INFUSION CANCER CHEMOTHERAPY BY THE WATKINS CHRONOMETRIC INFUSOR.
Topics: Adenoma; Antineoplastic Agents; Breast Neoplasms; Carcinosarcoma; Colonic Neoplasms; Dermatitis, Exfoliative; Equipment and Supplies; Floxuridine; Fluorouracil; Humans; Infusion Pumps; Infusions, Parenteral; Lung Neoplasms; Lymphoma, Non-Hodgkin; Male; Melanoma; Methotrexate; Mitomycin; Mitomycins; Pancreatic Neoplasms; Stomach Neoplasms; Testicular Neoplasms; Thyroid Neoplasms; Tongue Neoplasms; Toxicology | 1964 |
A COMPARISON OF THE EFFECTS OF SELECTED CYTOTOXIC AGENTS ON THE PRIMARY AGGLUTININ RESPONSE IN RATS INJECTED WITH SHEEP ERYTHROCYTES.
Topics: Agglutinins; Animals; Antibodies; Antibody Formation; Antigen-Antibody Reactions; Antigens; Antineoplastic Agents; Cyclophosphamide; Cytotoxins; Erythrocytes; Floxuridine; Fluorouracil; Immunity; Immunization; Mechlorethamine; Mercaptopurine; Methotrexate; Purines; Rats; Research; Sheep; Toxicology; Vinblastine | 1964 |
[REGIONAL CHEMOTHERAPY OF MALIGNANT TUMORS. I. PROLONGED INTRA-ARTERIAL INFUSION OF ANTIMETABOLITES].
Topics: Antimetabolites; Catheterization; Female; Floxuridine; Humans; Infusions, Intra-Arterial; Injections; Injections, Intra-Arterial; Mandibular Neoplasms; Maxillary Neoplasms; Methotrexate; Mouth Neoplasms; Nasopharyngeal Neoplasms; Neoplasms; Tongue Neoplasms; Uterine Cervical Neoplasms | 1964 |
CANCER CHEMOTHERAPY BY CONTINUOUS INTRA-ARTERIAL INFUSION. EXPERIENCE OF THE VETERANS ADMINISTRATION SURGICAL ADJUVANT CANCER CHEMOTHERAPY INFUSION STUDY GROUP.
Topics: Floxuridine; Geriatrics; Hemiplegia; Hemorrhage; Infusions, Intra-Arterial; Infusions, Parenteral; Leucovorin; Mechlorethamine; Methotrexate; Mortality; Neoplasms; Thiotepa; Toxicology; United States; United States Department of Veterans Affairs | 1964 |
REPLICATION OF A DEOXYRIBONUCLEIC ACID VIRUS IN THYMINE-DEFICIENT MAMMALIAN CELLS.
Topics: Animals; DNA; DNA Replication; DNA, Viral; Female; Floxuridine; Horses; Methotrexate; Nucleotides; Pharmacology; Pregnancy; Research; Thymidine; Thymine; Tissue Culture Techniques; Vertebrates; Virus Cultivation; Virus Replication; Viruses | 1964 |
PYRIMIDINE METABOLISM IN TISSUE CULTURE CELLS DERIVED FROM RAT HEPATOMAS. I. SUSPENSION CELL CULTURES DERIVED FROM THE NOVIKOFF HEPATOMA.
Topics: Animals; Carcinoma, Hepatocellular; Cell Culture Techniques; Floxuridine; Fluorouracil; Glycine; Liver Neoplasms; Liver Neoplasms, Experimental; Metabolism; Methotrexate; Mutation; Neoplasms; Neoplasms, Experimental; Nucleosides; Pharmacology; Pyrimidines; Rats; Research; Serine; Thymidine; Thymidine Kinase; Thymine; Tissue Culture Techniques; Toxicology; Uracil | 1965 |
ACUTE EFFECTS OF CYTOTOXIC COMPOUNDS ON INCORPORATION OF PRECURSORS INTO DNA, RNA, AND PROTEIN OF HELA MONOLAYERS.
Topics: Anti-Bacterial Agents; Antimetabolites; Dactinomycin; DNA; Floxuridine; HeLa Cells; Humans; Leucine; Mercaptopurine; Metabolism; Methotrexate; Nucleosides; Pharmacology; Proteins; Puromycin; Research; RNA; Streptonigrin; Thymidine; Tissue Culture Techniques; Triethylenemelamine; Urethane; Uridine; Vinblastine | 1965 |
THE COMPARISON OF RADIATION AND ANTIMETABOLITE RESPONSES OF GENETICALLY ALTERED MURINE LEUKEMIC CELLS.
Topics: Animals; Antimetabolites; Chromosomes; Floxuridine; Genetics; Idoxuridine; Leukemia; Leukemia, Experimental; Mast Cells; Methotrexate; Mice; Neoplasms; Neoplasms, Experimental; Nucleosides; Pharmacology; Pyrimethamine; Radiation Genetics; Research; Tissue Culture Techniques | 1965 |
[Case report--postoperative continuous intraarterial infusion of small doses of 5-FU successfully controlled residual tumor and liver metastasis of stage IV gastric cancer].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Disease-Free Survival; Doxorubicin; Drug Combinations; Floxuridine; Fluorouracil; Gastrectomy; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Lymph Node Excision; Lymph Nodes; Lymphatic Metastasis; Male; Methotrexate; Mitomycin; Neoplasm Staging; Picibanil; Proteoglycans; Stomach Neoplasms; Tegafur; Uracil | 2005 |
Metastasis of gestational trophoblastic neoplasia to the spinal canal: a case report.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chorionic Gonadotropin, beta Subunit, Human; Dactinomycin; Etoposide; Female; Floxuridine; Gestational Trophoblastic Disease; Humans; Magnetic Resonance Imaging; Methotrexate; Pregnancy; Spinal Canal; Spinal Neoplasms; Uterine Neoplasms; Vincristine; Young Adult | 2009 |
Inhibition of EGFR phosphorylation in a panel of human breast cancer cells correlates with synergistic interactions between gefitinib and 5'-DFUR, the bioactive metabolite of Xeloda.
Topics: Antineoplastic Agents; Breast Neoplasms; Capecitabine; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deoxycytidine; Drug Synergism; ErbB Receptors; Female; Floxuridine; Fluorouracil; Gefitinib; Gene Expression Regulation, Enzymologic; Humans; Inhibitory Concentration 50; Methotrexate; Phosphorylation; Protein Processing, Post-Translational; Quinazolines; Thymidine Phosphorylase; Thymidylate Synthase | 2012 |
Chemotherapy-induced toxicity is highly heritable in Drosophila melanogaster.
Topics: Animals; Carboplatin; Deoxycytidine; Dose-Response Relationship, Drug; Drosophila melanogaster; Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Female; Fertility; Floxuridine; Gemcitabine; High-Throughput Screening Assays; Humans; Methotrexate; Mitomycin; Models, Animal; Neoplasms; Topotecan | 2012 |
A thymidylate synthase ternary complex-specific antibody, FTS, permits functional monitoring of fluoropyrimidines dosing.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Monitoring; Female; Floxuridine; Fluorouracil; Immunoenzyme Techniques; Methotrexate; Mice; Mice, Nude; Pancreatic Neoplasms; Rats; Thymidylate Synthase; Transplantation, Heterologous; Tumor Cells, Cultured | 2012 |
Flaviviruses are sensitive to inhibition of thymidine synthesis pathways.
Topics: Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Dengue Virus; Disease Models, Animal; DNA Viruses; Flavivirus; Flavivirus Infections; Floxuridine; HEK293 Cells; HeLa Cells; Humans; Leucovorin; Methotrexate; Mice; Mice, 129 Strain; Mice, Inbred C57BL; RNA Viruses; Thymidine; Tumor Suppressor Protein p53; Vero Cells; Virus Replication; West Nile virus | 2013 |
CLIC1 Induces Drug Resistance in Human Choriocarcinoma Through Positive Regulation of MRP1.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Chloride Channels; Choriocarcinoma; Drug Resistance, Neoplasm; Female; Floxuridine; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Methotrexate; Mice, Inbred BALB C; Multidrug Resistance-Associated Proteins; Pregnancy; Uterine Neoplasms; Xenograft Model Antitumor Assays | 2017 |