floxuridine has been researched along with levoleucovorin in 151 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (18.54) | 18.7374 |
| 1990's | 67 (44.37) | 18.2507 |
| 2000's | 39 (25.83) | 29.6817 |
| 2010's | 15 (9.93) | 24.3611 |
| 2020's | 2 (1.32) | 2.80 |
| Authors | Studies |
|---|---|
| Morgenthaler, FR; Pettavel, J | 1 |
| Roberts, D; Warmath, EV | 1 |
| Heidelberger, C; Moran, RG; Mulkins, M | 1 |
| Fujiwara, Y; Nishio, K; Ohe, Y; Ohmori, T; Saijo, N; Sugimoto, Y | 1 |
| Goldman, ID; Rape, TJ; Seither, RL | 1 |
| Hoshi, A; Iigo, M; Nishikata, K | 1 |
| Kiyabu, M; Laine, L; Leichman, CG; Leichman, L; Muggia, FM; Radin, R; Ray, M; Silberman, H; Spears, CP; Stain, S | 1 |
| Charette, J; Stadler, WM; Vogelzang, NJ; Vokes, EE; Whitman, G | 1 |
| Bajetta, E; Colleoni, M; de Braud, F; Nelli, P; Nolè, F; Zilembo, N | 1 |
| Rustum, YM; Zhang, ZG | 1 |
| Bertino, JR; Davis, C; Durivage, HJ; Marsh, JC; O'Hollaren, K; Pasquale, DN; Simonich, SA; Voynick, IM | 1 |
| Harstrick, A; Rustum, YM; Zhang, ZG | 2 |
| Kemeny, N | 2 |
| Cloos, J; Noordhuis, P; Peters, GJ; Pinedo, HM; Smid, K; van der Wilt, CL | 1 |
| Encke, A; Hottenrott, C; Inglis, R; Lorenz, M; Maier, P; Reimann, M | 1 |
| O'Connell, MJ | 1 |
| Gordon, JH; Levin, RD; Mellijor, A; Sanchez, R; Simonich, W; Williams, RM | 1 |
| Rustum, YM; Yin, MB | 1 |
| Doroshow, JH; Raschko, JW; Ratain, MJ; Schilsky, RL; Vogelzang, NJ; Vokes, EE; Warfield, EE | 1 |
| Moran, RG; Scanlon, KL | 1 |
| Rustum, YM | 1 |
| Machover, D | 1 |
| Czajkowski, CA; Matherly, LH; Muench, SP; Psiakis, JT | 1 |
| Bertino, JR; Botet, J; Cohen, A; Kemeny, N; Oderman, P; Sigurdson, ER | 1 |
| Cheshire, PJ; de Graaf, SS; Houghton, JA; Houghton, PJ; Jadaud, P; Maneval, DC; Rodman, JH; Wainer, IW; Williams, LG | 1 |
| Bertino, JR; Romanini, A | 1 |
| Allegra, C; Gazdar, AF; Kramer, BS; Perng, RP; Tsai, CM | 1 |
| Anderson, N; Bern, M; Lokich, J; Moore, C; Wallach, S; Williams, D | 1 |
| Morgan, RG | 1 |
| Berger, SH; Davis, ST | 1 |
| Bertino, JR; Duafala, ME; Kleinberg, M; Markman, M; Morris, A; Smith, JA | 1 |
| Baba, T; Furukohri, N; Itoh, T; Munakata, A; Ogasawara, H; Saitoh, S; Sakata, Y; Tamura, Y; Tsushima, K; Yoshida, Y | 1 |
| Angelini, F; Carassai, A; Coppetelli, U; Lopez, M | 1 |
| Bertino, JR; Chang, YM | 1 |
| Keyomarsi, K; Moran, RG | 3 |
| Barlowe, CK; Goldman, ID; Matherly, LH; Phillips, VM | 1 |
| Bertino, JR; Mini, E; Moroson, BA | 1 |
| Fisher, K; Flam, M; Gandara, D; Hannigan, J; Hendrickson, C; Kohler, M; Richman, E; Valone, FH; Yu, KP | 1 |
| Lönn, S; Lönn, U | 1 |
| Allegra, CJ; Collins, JM; Gazdar, AF; Greene, RF; Kramer, BS; Park, JG; Steinberg, SM | 1 |
| Glimelius, B; Påhlman, L | 1 |
| Barbour, KW; Berger, FG; Berger, SH; Davis, ST | 1 |
| Keyomarsi, K; Moran, RG; Patel, R | 1 |
| Couture, J; Deschênes, L | 1 |
| Canellos, GP; Greenberg, NH; Mead, JA; Schrecker, AW | 1 |
| Handa, H; Mori, K; Onoyama, Y | 1 |
| Grossowicz, N; Mandelbaum-Shavit, F | 1 |
| Makulu, DR | 1 |
| Oberfield, RA | 1 |
| Fujioka, A; Nakano, K; Okabe, H; Saito, H; Takeda, S; Toko, T; Unemi, N | 1 |
| Chan, KK; Israel, VK; Jeffers, S; Jiang, C; Leichman, CG; Leichman, L; Morrow, CP; Muggia, FM; Roman, L; Tulpule, A | 1 |
| Leichman, CG | 1 |
| Lorenz, M; Rossion, I | 1 |
| Bajetta, E; Bozzetti, F; Buzzoni, R; Cappuzzo, F; Colleoni, M; Di Bartolomeo, M; Doci, R; Guenzi, A; Somma, L; Stampino, CG | 1 |
| Lévi, F | 1 |
| Chan, KK; Muggia, FM | 1 |
| Chan, KK; Chen, F; Jeffers, S; Leichman, CG; Leichman, L; Muggia, FM; Retzios, A; Spears, CP; Tulpule, A | 1 |
| Bertino, JR; Cohen, AM; Enker, W; Kelsen, DP; Saltz, L; Tao, Y; Tong, W; Yao, TJ | 1 |
| Bertino, JR; Botet, J; Campana, P; Cohen, A; Conti, JA; Huang, Y; Kemeny, N; Pulliam, S; Shi, WJ | 1 |
| Ahn, C; Akman, SA; Doroshow, JH; Leong, LA; Margolin, KA; Morgan, RJ; Newman, E; Raschko, JW; Somlo, G | 1 |
| Creaven, PJ; Frank, C; Levine, EG; Meropol, NJ; Petrelli, NJ; Proefrock, A; Raghavan, D; Rodriguez-Bigas, M; Rustum, YM; Udvary-Nagy, S | 1 |
| Ito, T; Komatsu, Y; Moriya, N; Ogasawara, H; Saito, S; Sakata, Y; Sugimoto, N; Tamura, Y; Tsushima, K; Yamada, Y | 1 |
| Castoldi, MC; Dellafiore, L; Pancera, G | 1 |
| Carrasco, H; Charnsangavej, C; Chase, J; Chuang, V; Fischer, H; Lawrence, D; Patt, YZ; Roh, M; Smith, R; Yoffe, B | 1 |
| Gordon, JH; Levin, RD | 1 |
| Bertino, JR; Botet, J; Budd, AJ; Chapman, D; Cohen, A; Conti, JA; Kemeny, N; Mazumdar, M; Seiter, K; Sigurdson, ER | 1 |
| Encke, A; Hottenrott, C; Lorenz, M | 1 |
| O'Brien, SM; Ratain, MJ; Schilsky, RL; Vogelzang, NJ; Vokes, EE | 1 |
| Ahlgren, JD; Anderson, N; Kemeny, N; Lokich, JJ | 1 |
| Botet, J; Chapman, D; Cohen, A; Conti, JA; Costa, P; Kemeny, N; Lincer, R; Niedzwiecki, D; Seiter, K; Sigurdson, E | 1 |
| Aschelter, A; Garufi, C; Giunta, S; Lévi, F; Nisticò, C; Pace, R; Terzoli, E | 1 |
| Doroshow, JH | 1 |
| Cao, S; Frank, C; Rustum, YM | 1 |
| Artale, S; Bajetta, E; Carnaghi, C; Colleoni, M; Di Bartolomeo, M; Di Leo, A; Pandolfi, A; Rimassa, L; Zilembo, N | 1 |
| Bajetta, E; Bordogna, G; Comella, G; Di Bartolomeo, M; Gebbia, V; Moreschi, M; Scanni, A; Somma, L; Stampino, CG; Turci, D | 1 |
| Bolanowska, WE; Coward, JK; Galivan, J; Haile, WH; Hart, BP; Magee, KJ; McGuire, JJ; Paul, B; Rhee, M; Russell, C | 1 |
| Lu, K; McGuire, JJ; Rustum, YM; Slocum, HK | 1 |
| Baranda, J; Casagrande, Y; Crookes, P; Groshen, S; Laine, L; Leichman, CG; Leichman, L; Silberman, H; Stain, S; Tan, M | 1 |
| Allen-Mersh, TG; Davies, M; Earlam, S; Fordy, C; Glover, C | 1 |
| Artale, S; Bajetta, E; Bignami, P; Buzzoni, R; Del Vecchio, M; Di Bartolomeo, M; Magnani, E; Somma, L; Zunino, F | 1 |
| Beger, HG; Butzer, U; Danenberg, KD; Danenberg, PV; Kornmann, M; Leder, GH; Lenz, HJ; Link, KH; Metzger, R; Pillasch, J; Safi, F; Weindel, M | 1 |
| Bernath, AM; Bolton, JS; Burch, P; Colon-Otero, G; Fitzgibbons, RJ; Krook, JE; Mailliard, JA; Nagorney, DM; O'Connell, MJ; Schroeder, G | 1 |
| Arnrich, M; Höffken, K; Kähler, G; Kath, R; Raida, M; Scheele, J | 1 |
| Bajetta, E; Biganzoli, L; Buzzoni, R; Carnaghi, C; Cassata, A; Di Bartolomeo, M; Galante, E; Mariani, L; Spagnoli, I; Stampino, CG | 1 |
| Agostino, I; Andreoli, F; Bartolini, P; Gemelli, MT; Neri, B; Pantalone, D; Pernice, ML; Scatizzi, M; Siliani, GM | 1 |
| Goldberg, RM | 1 |
| Gassel, HJ; Lorenz, M; Mattes, P; Müller, HH; Schramm, H; Stieger, R | 1 |
| Beger, HG; Kornmann, M; Leder, G; Link, KH; Pillasch, AF; Pressmar, J; Schatz, M; Sunelaitis, E | 1 |
| González Barón, M | 1 |
| Artale, S; Bajetta, E; Bozzetti, F; Buzzoni, R; Di Bartolomeo, M; Mazzaferro, V; Ricci, SB; Stani, SC; Toffolatti, L | 1 |
| Bertino, JR; Blumgart, LH; Brennan, MF; Cohen, AM; Conti, JA; Fong, Y; Huang, Y; Kemeny, N; Shi, W; Stockman, J; Sullivan, D; Turnbull, AD | 1 |
| Lorenz, M; Müller, HH | 1 |
| Fiehler, J; Höffken, K; Kath, R; Schneider, CP | 1 |
| Gen, T; Hara, Y; Igarashi, K; Jibiki, M; Kawasaki, T; Kikuchi, M; Kudoh, A; Noguchi, N; Yabata, E | 1 |
| Hochmuth, K; Lorenz, M; Müller, HH | 1 |
| Fata, F; Kemeny, N; Klimstra, D; Maluf, F; Ron, IG | 1 |
| Burzykowski, T; Buyse, M; Carlson, RW; Molenberghs, G; Piedbois, P; Thirion, P | 1 |
| Kowalski, MP; Maley, F; Maybaum, J; Parsels, JD; Parsels, LA; Wagner, LM | 1 |
| Allen-Mersh, TG; Fordy, C; Glover, C; Mathur, P; Quinn, H | 1 |
| Croockewit, A; Koopmans, PP; Lekkerkerker, JF; Schellens, J; van Bronswijk, H | 1 |
| Alexander, HR; Bartlett, DL; Figg, WD; Fraker, DL; Libutti, SK | 1 |
| Jung, HC; Kim, NK; Min, JS; Park, JK; Roh, JK; Sung, JS; Yun, SH | 1 |
| Baba, H; Ebuchi, M; Kure, N; Maruyama, M; Nagahama, T; Toukairin, Y; Yoshida, T | 1 |
| Cho, JH; Kim, NK; Min, JS; Seong, J; Suh, CO | 1 |
| Accurso, S; Danova, M; Girino, M; Palmeri, S; Porta, C; Riccardi, A; Tinelli, C | 1 |
| Garcia, AA; Jeffers, S; Koda, RT; Muggia, FM; Pujari, M; Silberman, H; Spears, CP | 1 |
| Lowy, AM | 1 |
| Brooks, AD; Cohen, AM; Culliford, AT; Guillem, JG; Ilson, DH; Kelsen, DP; Kemeny, NE; O'Reilly, EM; Paty, PB; Saltz, LB; Schwartz, GK; Sharma, S; Wong, WD | 1 |
| Andreola, S; Baratti, D; Bozzetti, F; Mariani, L; Spinelli, P; Stani, SC; Valvo, F | 1 |
| Janciauskiene, R; Juozaityte, E; Pavalkis, D | 1 |
| Ahn, JH; Kang, YK; Kim, JC; Kim, JG; Kim, TW; Kim, WK; Lee, JH; Lee, JS; Min, YJ; Yu, CS | 1 |
| Blesch, KS; Burger, HU; Gieschke, R; Reigner, B; Steimer, JL | 1 |
| Chen, A; Grem, JL; Hamilton, JM; Harold, N; Keith, B; Monahan, BP; Morrison, G; Nguyen, D; Pang, J; Quinn, MG; Rowedder, A; Takimoto, CH; Xu, Y | 1 |
| ROGERS, LS | 1 |
| Handa, R; Iijima, S; Kato, T; Kikkawa, N; Kurokawa, E; Naoi, Y; Oshima, S; Tsujie, M; Yamamoto, H | 1 |
| Canaparo, R; Casale, F; Costa, M; Eandi, M; Fornari, G; Mairone, L; Muntoni, E; Pepa, CD; Serpe, L; Zara, GP | 1 |
| Hazama, S; Mori, N; Oka, M; Tamesa, T; Tangoku, A; Watanabe, Y; Yamamoto, S; Yoshimura, K | 1 |
| Carroll, M; Faynsod, M; Leong, LA; Longmate, J; Wagman, LD | 1 |
| Kerr, C | 1 |
| Ardalan, B; Franceschi, D; Hamilton-Nelson, K; Lima, M; Livingstone, A; Parra, J; Ribeiro, A | 1 |
| Brennan, MF; Brenner, B; Coit, DG; Gonen, M; Karpeh, MS; Kelsen, DP; Klimstra, DS; Shah, MA; Tang, LH | 1 |
| Ebisui, C; Fujimoto, T; Fujiwara, S; Fukuchi, N; Hasuike, Y; Hayashi, N; Sakita, I; Tsujie, M; Yoshida, T | 1 |
| Ardalan, B; Franceschi, D; Kozyreva, O; Lima, M; Livingstone, A; Santos, E; Tsai, KT | 1 |
| Ardalan, B; Avisar, E; Bowen-Wells, CP; Franceschi, D; Ganjei-Azar, P; Lima, M; Livingstone, AS; Mezentsev, D; Rios, J; Sapp, M; Sparling, L; Spector, SA; Walker, G | 1 |
| Bang, SJ; Joo, KR; Kim, H; Kim, MJ; Min, YJ; Nah, YW; Nam, CW; Park, JH; Park, NH; Shin, SJ | 1 |
| D'Angelica, MI; Fong, Y; Jarnagin, WR; Kemeny, NE; Munoz, JA; Raggio, G; Schwartz, LH; White, RR | 1 |
| Healey-Bird, BR; Kemeny, NE; Power, DG | 1 |
| Khan, AZ; Makuuchi, M; Morris-Stiff, G | 1 |
| Capanu, M; D'Angelica, M; Dematteo, R; Fong, Y; Haviland, D; Jarnagin, W; Kemeny, N | 1 |
| Karapetis, C; Price, T; Townsend, A | 1 |
| Lise, M; Mammano, E; Mocellin, S; Nitti, D; Pilati, P; Tessari, E | 1 |
| Kemeny, NE; Power, DG | 1 |
| Breitenstein, S; Clavien, PA; Feilchenfeldt, J; Haile, SR; Heinrich, S; Knuth, A; Pestalozzi, BC; Renner, C; Samaras, P; Stenner-Liewen, F | 1 |
| Ardalan, B; Avisar, E; Franceschi, D; Lima, M; Livingstone, A; Mezentsev, D; Podolsky, L; Reis, I; Rios, J; Solomon, N | 1 |
| Alberts, SR; Bolton, JS; Farr, GH; Fitch, TR; Fuloria, J; Mahoney, MR; Maples, WJ; Nagorney, DM; O'Connell, MJ; Rubin, J; Steen, PD | 1 |
| Chandra, A; Chang, RY; Cohen, DJ; Donahue, B; Hiotis, S; Hochster, H; Iqbal, S; Liu, M; Muggia, F; Newman, E; Pachter, LH; Potmesil, M; Ryan, T; Utate, M | 1 |
| Aronova, A; Chung, KY; Jones, D; Kelsen, D; Nash, GM; O'Reilly, EM; Paty, PB; Shia, J; Temple, LK; Wagner, PL; Weiser, MR | 1 |
| Chen, Y; Liu, Q; Luo, J; Wang, J; Wang, X; Yan, Z | 1 |
| Bhinder, B; Djaballah, H; Fischer, MA; Früh, K; Hirsch, AJ; Nelson, JA; Parkins, C; Radu, C; Shum, D; Smith, JL; Stein, DA | 1 |
| Allard, MA; Malka, D | 1 |
| Chen, C; Chen, G; Ding, P; Gu, Y; He, Y; Li, C; Li, W; Li, Y; Lu, Z; Luo, H; Pan, Z; Wan, D; Wang, F; Wang, Z; Wu, X; Xu, R; Yuan, Y; Zhao, M | 1 |
| Chang, W; Chen, J; Niu, W; Qin, C; Qin, X; Ren, L; Wei, Y; Xu, J; Ye, L; Yu, Y; Zhao, N; Zhong, Y; Zhu, D | 1 |
| Allen, PJ; Boucher, TM; Capanu, M; Cercek, A; Chou, JF; D'Angelica, MI; DeMatteo, RP; Fong, YC; Jarnagin, WR; Kemeny, NE | 1 |
| Ben-Josef, E; Ensminger, W; Feng, M; Hanasoge, S; Lawrence, TS; Normolle, DP; Sapir, E; Schipper, MJ; Shilkrut, M | 1 |
| Capanu, M; Chatila, WK; Chou, JF; Connell, LC; D'Angelica, MI; Jarnagin, WR; Kemeny, NE; Kingham, TP; Sanchez-Vega, F; Shi, H | 1 |
| Gromprasit, A; Jitprapaikulsarn, S; Patamamongkonchai, C; Sukha, K; Thremthakanpon, W | 1 |
| Allen, PJ; Balachandran, VP; Boucher, T; Capanu, M; Cercek, A; Chou, JF; D'Angelica, MI; DeMatteo, RP; Jarnagin, WR; Kemeny, NE; Kingham, TP; Pak, LM | 1 |
22 review(s) available for floxuridine and levoleucovorin
| Article | Year |
|---|---|
Review of regional therapy of liver metastases in colorectal cancer.
Topics: Colorectal Neoplasms; Floxuridine; Hepatic Artery; Humans; Infusion Pumps; Infusions, Intra-Arterial; Leucovorin; Liver Function Tests; Liver Neoplasms; Randomized Controlled Trials as Topic | 1992 |
Is hepatic infusion of chemotherapy effective treatment for liver metastases? No!
Topics: Antineoplastic Agents; Colorectal Neoplasms; Floxuridine; Fluorouracil; Forecasting; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Injections, Intravenous; Leucovorin; Liver Neoplasms; Mitomycin; Survival Rate | 1992 |
Modulation of fluoropyrimidines by leucovorin: rationale and status.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Administration Schedule; Floxuridine; Fluorouracil; Humans; Leucovorin | 1991 |
Developments of the fluoropyrimidines as inhibitors of thymidylate synthetase: pharmacologic and clinical aspects.
Topics: Animals; Antineoplastic Agents; Colorectal Neoplasms; Drug Synergism; Floxuridine; Fluorouracil; Humans; Leucovorin; Organoplatinum Compounds; Prodrugs; Pyrimidines; Thymidylate Synthase | 1991 |
Leucovorin enhancement of the effects of the fluoropyrimidines on thymidylate synthase.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Synergism; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Leucovorin; Neoplasms; Thymidylate Synthase | 1989 |
[Current results and prospects of intra-arterial chemotherapy in hepatic metastases of carcinoma of the colorectum].
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colorectal Neoplasms; Floxuridine; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Random Allocation | 1989 |
Cytostatic drug therapy in disseminated colorectal cancer.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Leucovorin; Methotrexate; Semustine; Vincristine | 1988 |
Prolonged infusion of fluorinated pyrimidines in gastrointestinal malignancies: a review of recent clinical trials.
Topics: Carcinoma, Squamous Cell; Circadian Rhythm; Cisplatin; Clinical Trials as Topic; Colorectal Neoplasms; Drug Administration Schedule; Esophageal Neoplasms; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Interferons; Leucovorin | 1994 |
[Adjuvant and palliative regional therapy of liver metastases in colorectal tumors].
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Chemotherapy, Cancer, Regional Perfusion; Colorectal Neoplasms; Combined Modality Therapy; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Palliative Care; Randomized Controlled Trials as Topic; Time Factors | 1995 |
Recent advances in the treatment of advanced colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Drug Administration Schedule; Drug Interactions; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Hydroxyurea; Infusions, Intra-Arterial; Leucovorin; Methotrexate; Neoplasm Staging; Phosphonoacetic Acid; Prospective Studies; Randomized Controlled Trials as Topic | 1993 |
Biochemical modulation of fluoropyrimidines: is there an optimal (6R,S) leucovorin dose and schedule?
Topics: Animals; Antimetabolites, Antineoplastic; Colonic Neoplasms; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Leucovorin | 1996 |
Is repeated treatment with a 5-fluorouracil-based regimen useful in colorectal cancer?
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Injections, Intravenous; Irinotecan; Leucovorin; Liver Neoplasms; Organoplatinum Compounds; Oxaliplatin; Randomized Controlled Trials as Topic; Salvage Therapy | 1998 |
Basic research supported developments of chemotherapy in nonresectable isolated colorectal liver metastases to a protocol of hepatic artery infusion using mitoxantrone, 5-FU + folinic acid and mitomycin C.
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colorectal Neoplasms; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Male; Middle Aged; Mitomycin; Mitoxantrone; Randomized Controlled Trials as Topic; Survival Analysis | 1999 |
[Oral fluoropyrimidines in oncology].
Topics: Administration, Oral; Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Clinical Trials as Topic; Combined Modality Therapy; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Male; Neoplasm Recurrence, Local; Neoplasms; Tegafur; Time Factors; Uracil | 1998 |
Gastric cancer in very young adults: apropos four patients and a review of the literature.
Topics: Adult; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Signet Ring Cell; Cisplatin; Doxorubicin; Female; Floxuridine; Helicobacter pylori; Humans; Leucovorin; Male; Pregnancy; Pregnancy Complications, Neoplastic; Preoperative Care; Stomach Neoplasms; Treatment Outcome | 2000 |
Relation between tumour response to first-line chemotherapy and survival in advanced colorectal cancer: a meta-analysis. Meta-Analysis Group in Cancer.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Floxuridine; Fluorouracil; Leucovorin; Methotrexate; Randomized Controlled Trials as Topic; Survival Analysis; Treatment Outcome | 2000 |
[The role of the regional (intra-arterial) chemotherapy in the treatment of hepatic metastases of colorectal cancer].
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Carmustine; Colorectal Neoplasms; Cross-Over Studies; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Meta-Analysis as Topic; Mitomycin; Prospective Studies; Randomized Controlled Trials as Topic; Time Factors | 2003 |
Regional chemotherapy for liver-limited metastatic colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Colorectal Neoplasms; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Irinotecan; Leucovorin; Liver Neoplasms; Mitomycin; Neoadjuvant Therapy; Organoplatinum Compounds; Oxaliplatin | 2008 |
Patterns of chemotherapy-induced hepatic injury and their implications for patients undergoing liver resection for colorectal liver metastases.
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Combined Modality Therapy; Fatty Liver; Floxuridine; Fluorouracil; Hepatectomy; Hepatic Veno-Occlusive Disease; Humans; Irinotecan; Leucovorin; Liver; Liver Neoplasms; Neoadjuvant Therapy; Organoplatinum Compounds; Oxaliplatin; Risk Factors | 2009 |
Selective internal radiation therapy for liver metastases from colorectal cancer.
Topics: Antimetabolites, Antineoplastic; Colorectal Neoplasms; Combined Modality Therapy; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Microspheres; Radiotherapy; Randomized Controlled Trials as Topic; Yttrium Radioisotopes | 2009 |
Chemotherapy for the conversion of unresectable colorectal cancer liver metastases to resection.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biological Therapy; Camptothecin; Chemotherapy, Adjuvant; Colorectal Neoplasms; Floxuridine; Fluorouracil; Hepatectomy; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Organoplatinum Compounds; Survival Analysis; Treatment Outcome | 2011 |
Place of hepatic intra-arterial chemotherapy in the treatment of colorectal liver metastases.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Colorectal Neoplasms; Floxuridine; Hepatectomy; Hepatic Artery; Humans; Infusions, Intra-Arterial; Irinotecan; Leucovorin; Liver Neoplasms; Organoplatinum Compounds; Oxaliplatin; Palliative Care; Treatment Outcome | 2014 |
62 trial(s) available for floxuridine and levoleucovorin
| Article | Year |
|---|---|
Preoperative systemic chemotherapy followed by adjuvant postoperative intraperitoneal therapy for gastric cancer: a University of Southern California pilot program.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Drug Administration Schedule; Feasibility Studies; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Infusions, Parenteral; Leucovorin; Male; Middle Aged; Pilot Projects; Stomach Neoplasms; Survival Analysis; Treatment Outcome | 1992 |
Continuous-infusion fluorodeoxyuridine with leucovorin and high-dose interferon: a phase II study in metastatic renal-cell cancer.
Topics: Administration, Oral; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Combined Modality Therapy; Floxuridine; Humans; Infusions, Intravenous; Injections, Subcutaneous; Interferon-alpha; Kidney Neoplasms; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Time Factors | 1992 |
Phase II study of pulse 5-fluoro-2'-deoxyuridine and leucovorin in advanced colorectal cancer patients previously treated with chemotherapy.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Administration Schedule; Drug Evaluation; Drug Synergism; Floxuridine; Humans; Infusions, Intravenous; Leucovorin; Survival Analysis | 1992 |
Continuous regional treatment with fluoropyrimidines for metastases from colorectal carcinomas: influence of modulation with leucovorin.
Topics: Colorectal Neoplasms; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusion Pumps; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Male | 1992 |
Is hepatic infusion of chemotherapy effective treatment for liver metastases? No!
Topics: Antineoplastic Agents; Colorectal Neoplasms; Floxuridine; Fluorouracil; Forecasting; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Injections, Intravenous; Leucovorin; Liver Neoplasms; Mitomycin; Survival Rate | 1992 |
Phase I clinical trial with floxuridine and high-dose continuous infusion of leucovorin calcium.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Evaluation; Female; Floxuridine; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Neoplasms; Remission Induction | 1991 |
Five-day infusion of fluorodeoxyuridine with high-dose oral leucovorin: a phase I study.
Topics: Aged; Dose-Response Relationship, Drug; Drug Evaluation; Drug Therapy, Combination; Female; Floxuridine; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Neoplasms; Remission Induction; Time Factors | 1991 |
[Current results and prospects of intra-arterial chemotherapy in hepatic metastases of carcinoma of the colorectum].
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colorectal Neoplasms; Floxuridine; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Random Allocation | 1989 |
A Northern California Oncology Group randomized trial of leucovorin plus 5-fluorouracil versus sequential methotrexate, 5-fluorouracil, and leucovorin in patients with advanced colorectal cancer who failed treatment with 5-fluorouracil or 5-fluorodeoxyuri
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Colonic Neoplasms; Drug Administration Schedule; Drug Resistance; Floxuridine; Fluorouracil; Humans; Leucovorin; Methotrexate; Rectal Neoplasms | 1987 |
Cytostatic drug therapy in disseminated colorectal cancer.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Leucovorin; Methotrexate; Semustine; Vincristine | 1988 |
Intraperitoneal 5-fluoro-2'-deoxyuridine (FUDR) and (S)-leucovorin for disease predominantly confined to the peritoneal cavity: a pharmacokinetic and toxicity study.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Female; Floxuridine; Humans; Injections, Intraperitoneal; Leucovorin; Male; Middle Aged; Peritoneal Neoplasms; Treatment Outcome | 1995 |
Doxifluridine and leucovorin: an oral treatment combination in advanced colorectal cancer.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Administration Schedule; Drug Resistance, Neoplasm; Female; Floxuridine; Gastrointestinal Diseases; Humans; Leucovorin; Male; Middle Aged; Survival Rate; Treatment Outcome | 1995 |
[Chrono-chemotherapy and dose intensity].
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chronobiology Phenomena; Circadian Rhythm; Cisplatin; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Infusion Pumps; Interferon-alpha; Leucovorin; Male; Mice; Neoplasms; Neoplasms, Experimental; Organoplatinum Compounds; Ovarian Neoplasms; Oxaliplatin; Rats | 1995 |
Intraperitoneal 5-fluoro-2'-deoxyuridine with escalating doses of leucovorin: pharmacology and clinical tolerance.
Topics: Abdominal Neoplasms; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; Floxuridine; Half-Life; Humans; Infusions, Parenteral; Leucovorin; Male; Metabolic Clearance Rate; Peritoneal Neoplasms | 1994 |
A phase I trial of immediate postoperative intraperitoneal floxuridine and leucovorin plus systemic 5-fluorouracil and levamisole after resection of high risk colon cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Combined Modality Therapy; Female; Floxuridine; Fluorouracil; Humans; Infusions, Parenteral; Leucovorin; Levamisole; Male; Middle Aged; Neoplasm Recurrence, Local; Postoperative Period; Survival Analysis | 1994 |
Phase II study of hepatic arterial floxuridine, leucovorin, and dexamethasone for unresectable liver metastases from colorectal carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bilirubin; Colorectal Neoplasms; Dexamethasone; Female; Floxuridine; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Function Tests; Liver Neoplasms; Male; Middle Aged; Survival Analysis | 1994 |
Phase I study of 5-day continuous infusion fluorodeoxyuridine and high-dose folinic acid with oral hydroxyurea.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Diarrhea; Drug Administration Schedule; Female; Floxuridine; Humans; Hydroxyurea; Infusions, Intravenous; Leucovorin; Lung Neoplasms; Male; Middle Aged; Thymidylate Synthase | 1994 |
Phase I and pharmacokinetic evaluation of floxuridine/leucovorin given on the Roswell Park weekly regimen.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; Floxuridine; Humans; Leucovorin; Male; Middle Aged; Neoplasms; Treatment Outcome | 1994 |
[Randomized controlled study of sequential methotrexate and 5-fluorouracil therapy with or without 5'-deoxy-5-fluorouridine against advanced gastrointestinal cancer. Hirosaki Cooperative Study Group for Cancer Chemotherapy].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Quality of Life; Survival Analysis | 1994 |
Hepatic arterial infusion of floxuridine, leucovorin, doxorubicin, and cisplatin for hepatocellular carcinoma: effects of hepatitis B and C viral infection on drug toxicity and patient survival.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Cisplatin; Doxorubicin; Female; Floxuridine; Hepatic Artery; Hepatitis B; Hepatitis C; Humans; Infusion Pumps; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Male; Middle Aged; Pilot Projects; Survival Rate | 1994 |
Fluorodeoxyuridine with continuous leucovorin infusion. A phase II clinical trial in patients with metastatic colorectal cancer.
Topics: Adult; Aged; Colorectal Neoplasms; Diarrhea; Drug Therapy, Combination; Female; Floxuridine; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Remission Induction; Stomatitis; Survival Rate | 1993 |
Hepatic arterial floxuridine and leucovorin for unresectable liver metastases from colorectal carcinoma. New dose schedules and survival update.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Colorectal Neoplasms; Drug Administration Schedule; Female; Floxuridine; Hepatic Artery; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Male; Middle Aged; Survival Analysis | 1994 |
Five-day infusional fluorodeoxyuridine with oral leucovorin and escalating doses of interferon alpha-2b: a phase I study.
Topics: Administration, Oral; Adult; Aged; Cohort Studies; Drug Administration Schedule; Female; Floxuridine; Humans; Infusions, Intravenous; Interferon alpha-2; Interferon-alpha; Leucovorin; Male; Middle Aged; Mouth Mucosa; Neoplasms; Recombinant Proteins; Stomatitis | 1993 |
A pilot study of hepatic artery floxuridine combined with systemic 5-fluorouracil and leucovorin. A potential adjuvant program after resection of colorectal hepatic metastases.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Male; Middle Aged; Pilot Projects; Survival Rate | 1993 |
Chronomodulated 5-day infusion of floxuridine and L-folinic acid in patients with advanced malignancies: a feasibility and tolerability study.
Topics: Adult; Aged; Antidotes; Antimetabolites, Antineoplastic; Carcinoma, Renal Cell; Chronobiology Phenomena; Colorectal Neoplasms; Drug Administration Schedule; Feasibility Studies; Female; Floxuridine; Humans; Infusions, Intravenous; Kidney Neoplasms; Leucovorin; Male; Middle Aged; Neoplasms; Stomach Neoplasms | 1995 |
Randomized phase II noncomparative trial of oral and intravenous doxifluridine plus levo-leucovorin in untreated patients with advanced colorectal carcinoma.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antidotes; Antineoplastic Agents; Colorectal Neoplasms; Female; Floxuridine; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Survival Rate | 1996 |
Systemic chemotherapy for gastric carcinoma followed by postoperative intraperitoneal therapy: a final report.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Infusions, Parenteral; Leucovorin; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Stomach Neoplasms; Tomography, X-Ray Computed | 1997 |
Effect of regional and systemic fluorinated pyrimidine chemotherapy on quality of life in colorectal liver metastasis patients.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Middle Aged; Pain Measurement; Quality of Life; Survival Analysis | 1997 |
Doxifluridine in colorectal cancer patients resistant to 5-fluorouracil (5-FU) containing regimens.
Topics: Administration, Oral; Adult; Aged; Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Agents; Colorectal Neoplasms; Drug Resistance, Neoplasm; Drug Therapy, Combination; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Tomography, X-Ray Computed | 1997 |
Thymidylate synthase is a predictor for response and resistance in hepatic artery infusion chemotherapy.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Colorectal Neoplasms; Drug Administration Schedule; Drug Resistance, Neoplasm; Epirubicin; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Male; Middle Aged; Mitoxantrone; Polymerase Chain Reaction; Predictive Value of Tests; Prognosis; RNA, Messenger; Survival Rate; Thymidylate Synthase; Transcription, Genetic | 1997 |
Sequential intrahepatic fluorodeoxyuridine and systemic fluorouracil plus leucovorin for the treatment of metastatic colorectal cancer confined to the liver.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease-Free Survival; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Leucovorin; Liver Neoplasms; Male; Middle Aged; Treatment Outcome | 1998 |
A phase II study of weekly high-dose 5-fluorouracil and leucovorin plus biweekly alternating doxorubicin and cisplatin for advanced gastric carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Dose-Response Relationship, Drug; Doxorubicin; Female; Floxuridine; Humans; Leucovorin; Male; Middle Aged; Stomach Neoplasms | 1998 |
Oral doxifluridine plus levoleucovorin in elderly patients with advanced breast cancer.
Topics: Administration, Oral; Aged; Aged, 80 and over; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Methotrexate; Neoplasm Staging | 1998 |
Results of leucovorin and doxifluridine oral regimen in the treatment of metastatic colorectal cancer.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Female; Floxuridine; Humans; Italy; Leucovorin; Male; Middle Aged; Treatment Outcome | 1998 |
[Intra-arterial (5-FU/FA and FUDR) versus systemic chemotherapy (5-FU/FA) of non-resectable colorectal liver metastases].
Topics: Adult; Aged; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Leucovorin; Liver Neoplasms; Male; Middle Aged; Prospective Studies; Survival Rate; Treatment Outcome | 1998 |
Hepatic arterial infusion of chemotherapy after resection of hepatic metastases from colorectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Combined Modality Therapy; Dexamethasone; Disease-Free Survival; Equipment Failure; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Infusions, Intravenous; Leucovorin; Liver Neoplasms; Male; Middle Aged; Survival Rate | 1999 |
Randomized, multicenter trial of fluorouracil plus leucovorin administered either via hepatic arterial or intravenous infusion versus fluorodeoxyuridine administered via hepatic arterial infusion in patients with nonresectable liver metastases from colore
Topics: Adenocarcinoma; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Catheters, Indwelling; Colonic Neoplasms; Disease Progression; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Leucovorin; Liver Neoplasms; Male; Middle Aged; Rectal Neoplasms; Survival Analysis; Treatment Outcome | 2000 |
Randomized trial of regional plus systemic fluorinated pyrimidine compared with systemic fluorinated pyrimidine in treatment of colorectal liver metastases.
Topics: Aged; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Carcinoembryonic Antigen; Colorectal Neoplasms; Disease Progression; Female; Floxuridine; Hematinics; Hepatic Artery; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Leucovorin; Liver Neoplasms; Male; Middle Aged; Quality of Life; Survival Analysis; Treatment Outcome | 2000 |
Isolated hepatic perfusion for unresectable hepatic metastases from colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Cancer, Regional Perfusion; Colorectal Neoplasms; Combined Modality Therapy; Dose-Response Relationship, Drug; Female; Floxuridine; Humans; Hyperthermia, Induced; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Male; Melphalan; Middle Aged; Neoplasm Metastasis; Radiography; Survival Analysis; Tumor Necrosis Factor-alpha | 2001 |
Intravenous 5-fluorouracil versus oral doxifluridine as preoperative concurrent chemoradiation for locally advanced rectal cancer: prospective randomized trials.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Combined Modality Therapy; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Prospective Studies; Quality of Life; Rectal Neoplasms | 2001 |
[Preoperative chemotherapy for advanced colorectal carcinomas--comparison of histological effect between 5'-DFUR + leucovorin tablet and 5'-DFUR alone].
Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Drug Administration Schedule; Female; Floxuridine; Humans; Leucovorin; Lymphatic Metastasis; Male; Middle Aged; Preoperative Care; Tablets | 2001 |
Preoperative chemoradiotherapy with oral doxifluridine plus low-dose oral leucovorin in unresectable primary rectal cancer.
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Diarrhea; Female; Floxuridine; Humans; Leucovorin; Male; Middle Aged; Preoperative Care; Radiotherapy; Rectal Neoplasms; Thrombocytopenia | 2001 |
Phase I and pharmacologic study of i.v. hydroxyurea infusion given with i.p. 5-fluoro-2'-deoxyuridine and leucovorin.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Female; Floxuridine; Humans; Hydroxyurea; Injections, Intraperitoneal; Injections, Intravenous; Leucovorin; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Time Factors | 2001 |
Preoperative chemoradiation in patients with resectable rectal cancer: results on tumor response.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Rectal Neoplasms; Treatment Outcome | 2002 |
Oral doxifluridine plus leucovorin in metastatic colorectal cancer: randomized phase II trial with intravenous 5-fluorouracil plus leucovorin.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Survival Analysis | 2003 |
Population pharmacokinetics and concentration-effect relationships of capecitabine metabolites in colorectal cancer patients.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; beta-Alanine; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Male; Middle Aged | 2003 |
A phase I and pharmacologic study of weekly gemcitabine in combination with infusional 5-fluorodeoxyuridine and oral calcium leucovorin.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Drug Administration Schedule; Female; Floxuridine; Gemcitabine; Humans; Infusions, Intravenous; Leucovorin; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Neutropenia; Ribonucleotide Reductases; Thrombocytopenia | 2003 |
Plasma concentrations of 5-fluorouracil and its metabolites in colon cancer patients.
Topics: Adult; Aged; Area Under Curve; Chromatography, High Pressure Liquid; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Injections, Intravenous; Kinetics; Leucovorin; Male; Middle Aged; Uridine | 2004 |
Improved hepatic toxicity profile of portal vein adjuvant hepatic infusional chemotherapy.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Liver Neoplasms; Male; Middle Aged; Portal Vein | 2005 |
A phase II trial of neoadjuvant cisplatin-fluorouracil followed by postoperative intraperitoneal floxuridine-leucovorin in patients with locally advanced gastric cancer.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Disease-Free Survival; Endoscopy, Digestive System; Feasibility Studies; Female; Floxuridine; Fluorouracil; Humans; Injections, Intraperitoneal; Leucovorin; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Postoperative Period; Quality of Life; Stomach Neoplasms; Survival Analysis; Treatment Failure | 2006 |
A phase II study of irinotecan, high-dose 24-h continuous intravenous infusion of floxuridine and leucovorin (IFLUX) for advanced, previously untreated colorectal cancer.
Topics: Adult; Aged; Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Disease Progression; Female; Floxuridine; Hematologic Diseases; Humans; Infusions, Intravenous; Irinotecan; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Survival Rate | 2007 |
Neoadjuvant, surgery and adjuvant chemotherapy without radiation for esophageal cancer.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Esophageal Neoplasms; Esophagectomy; Female; Floxuridine; Humans; Leucovorin; Male; Middle Aged; Neoadjuvant Therapy; Paclitaxel | 2007 |
Fixed dose rate infusion of gemcitabine with oral doxifluridine and leucovorin for advanced unresectable pancreatic cancer: a phase II study.
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Disease-Free Survival; Female; Floxuridine; Follow-Up Studies; Gemcitabine; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Pancreatic Neoplasms; Remission Induction; Survival Analysis; Treatment Outcome | 2008 |
Phase I trial of adjuvant hepatic arterial infusion (HAI) with floxuridine (FUDR) and dexamethasone plus systemic oxaliplatin, 5-fluorouracil and leucovorin in patients with resected liver metastases from colorectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cohort Studies; Colorectal Neoplasms; Disease-Free Survival; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Survival Rate; Treatment Outcome; Vitamin B Complex | 2009 |
A phase II study of neoadjuvant and adjuvant chemotherapy with 5-fluorodeoxyuridine, leucovorin, oxaliplatin and docetaxel in the treatment of previously untreated advanced esophageal adenocarcinoma.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Disease-Free Survival; Docetaxel; Esophageal Neoplasms; Esophagectomy; Female; Floxuridine; Follow-Up Studies; Gastrectomy; Humans; Kaplan-Meier Estimate; Leucovorin; Lymphatic Metastasis; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Taxoids; Time Factors; Treatment Outcome | 2011 |
Hepatic arterial infusion and systemic chemotherapy after multiple metastasectomy in patients with colorectal carcinoma metastatic to the liver: a North Central Cancer Treatment Group (NCCTG) phase II study, 92-46-52.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Combined Modality Therapy; Cryosurgery; Female; Floxuridine; Fluorouracil; Follow-Up Studies; Hepatic Artery; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Lymphatic Metastasis; Male; Metastasectomy; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Survival Rate; Treatment Outcome | 2012 |
Hepatic arterial infusion with irinotecan, oxaliplatin, and floxuridine plus systemic chemotherapy as first-line treatment of unresectable liver metastases from colorectal cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Female; Floxuridine; Hepatic Artery; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Irinotecan; Leucovorin; Liver Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Survival Rate; Treatment Outcome | 2012 |
Phase I trial of hepatic arterial infusion (HAI) of floxuridine with modified oxaliplatin, 5-fluorouracil and leucovorin (m-FOLFOX6) in Chinese patients with unresectable liver metastases from colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asian People; China; Colorectal Neoplasms; Diarrhea; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Male; Middle Aged; Neutropenia; Organoplatinum Compounds; Oxaliplatin; Survival Analysis; Treatment Outcome; Young Adult | 2014 |
Randomized Controlled Trial of Intraportal Chemotherapy Combined With Adjuvant Chemotherapy (mFOLFOX6) for Stage II and III Colon Cancer.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Chemotherapy, Adjuvant; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Survival Rate; Tomography, X-Ray Computed; Treatment Outcome | 2016 |
Phase I Trial of Dose-escalated Whole Liver Irradiation With Hepatic Arterial Fluorodeoxyuridine/Leucovorin and Streptozotocin Followed by Fluorodeoxyuridine/Leucovorin and Chemoembolization for Patients With Neuroendocrine Hepatic Metastases.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Neuroendocrine; Chemoembolization, Therapeutic; Combined Modality Therapy; Female; Floxuridine; Follow-Up Studies; Hepatic Artery; Humans; Leucovorin; Liver Neoplasms; Male; Middle Aged; Prognosis; Radiotherapy Dosage; Streptozocin; Survival Rate | 2018 |
A Randomized Phase II Trial of Adjuvant Hepatic Arterial Infusion and Systemic Therapy With or Without Panitumumab After Hepatic Resection of KRAS Wild-type Colorectal Cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Leucovorin; Male; Middle Aged; Panitumumab; Proto-Oncogene Proteins p21(ras) | 2021 |
Prospective phase II trial of combination hepatic artery infusion and systemic chemotherapy for unresectable colorectal liver metastases: Long term results and curative potential.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colorectal Neoplasms; Deoxyuridine; Disease-Free Survival; Female; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Irinotecan; Leucovorin; Liver Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Prospective Studies; Survival Rate; Treatment Outcome | 2018 |
70 other study(ies) available for floxuridine and levoleucovorin
| Article | Year |
|---|---|
[Treatment of primary and secondary liver tumors using a combination of chemotherapy and surgery].
Topics: Antineoplastic Agents; Carmustine; Drug Therapy, Combination; Floxuridine; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Methods; Methotrexate; Remission, Spontaneous; Vincristine | 1975 |
Methotrexate inhibition of CCRF-CEM cultures of human lymphoblasts.
Topics: Cell Division; Cell Line; Deoxycytidine; Deoxyuridine; DNA, Neoplasm; Floxuridine; Folic Acid Antagonists; Humans; Hypoxanthines; Leucovorin; Leukemia, Lymphoid; Methotrexate; Purines; Thymidine | 1975 |
Role of thymidylate synthetase activity in development of methotrexate cytotoxicity.
Topics: Animals; Cell Division; Cells, Cultured; Floxuridine; Humans; Hypoxanthines; Leucovorin; Leukemia, Experimental; Methotrexate; Methyltransferases; Mice; Thymidine; Thymidylate Synthase | 1979 |
In vitro enhancement of fluoropyrimidine-induced cytotoxicity by leucovorin in colorectal and gastric carcinoma cell lines but not in non-small-cell lung carcinoma cell lines.
Topics: Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Cell Survival; Colony-Forming Units Assay; Colorectal Neoplasms; Drug Synergism; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Leucovorin; Lung Neoplasms; Stomach Neoplasms; Tetrahydrofolates; Thymidylate Synthase; Tumor Cells, Cultured | 1992 |
Interconversion of tetrahydrofolate cofactors to dihydrofolate induced by trimetrexate after suppression of thymidylate synthase by fluorodeoxyuridine in L1210 leukemia cells.
Topics: Animals; Computer Simulation; Deoxyuridine; DNA; Enzyme Reactivators; Floxuridine; Folic Acid; Folic Acid Antagonists; Leucovorin; Leukemia L1210; Mice; Purines; Tetrahydrofolates; Thermodynamics; Thymidylate Synthase; Time Factors; Trimetrexate; Tumor Cells, Cultured | 1992 |
In vivo antitumor effects of fluoropyrimidines on colon adenocarcinoma 38 and enhancement by leucovorin.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Cell Division; Colonic Neoplasms; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Leucovorin; Male; Mice; Mice, Inbred Strains; Thymidylate Synthase; Uridine | 1992 |
Reversal of resistance to doxifluridine and fluorouracil in metastatic colorectal cancer: the role of high-dose folinic acid.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Resistance; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Metastasis | 1992 |
Pharmacologic rationale for fluoropyrimidine-leucovorin combination: biochemical mechanisms.
Topics: Cecal Neoplasms; Drug Administration Schedule; Drug Synergism; Floxuridine; Humans; Ileal Neoplasms; Kidney Neoplasms; Leucovorin; Stereoisomerism; Tetrahydrofolates; Thymidylate Synthase; Tumor Cells, Cultured | 1992 |
Modulation of fluoropyrimidines: role of dose and schedule of leucovorin administration.
Topics: Clinical Trials as Topic; Drug Administration Schedule; Floxuridine; Humans; Leucovorin; Tetrahydrofolates; Tumor Cells, Cultured | 1992 |
Effect of folinic acid on fluorouracil activity and expression of thymidylate synthase.
Topics: Animals; Colonic Neoplasms; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Leucovorin; Mice; Mice, Inbred BALB C; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured; Uridine Monophosphate | 1992 |
Mechanisms of resistance to fluoropyrimidines.
Topics: Cecal Neoplasms; Deoxyuracil Nucleotides; Drug Resistance; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Ileal Neoplasms; Leucovorin; Tetrahydrofolates; Thymidylate Synthase; Tumor Cells, Cultured | 1992 |
Comparative DNA strand breakage induced by FUra and FdUrd in human ileocecal adenocarcinoma (HCT-8) cells: relevance to cell growth inhibition.
Topics: Adenocarcinoma; Cell Division; Colonic Neoplasms; DNA; DNA Damage; Dose-Response Relationship, Drug; Drug Synergism; Floxuridine; Fluorouracil; Humans; In Vitro Techniques; Leucovorin; Thymidine; Time Factors | 1991 |
Schedule-dependent enhancement of the cytotoxicity of fluoropyrimidines to human carcinoma cells in the presence of folinic acid.
Topics: Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Floxuridine; Fluorouracil; Humans; Leucovorin; Tumor Cells, Cultured | 1991 |
Role for cytosolic folate-binding proteins in the compartmentation of endogenous tetrahydrofolates and the 5-formyl tetrahydrofolate-mediated enhancement of 5-fluoro-2'-deoxyuridine antitumor activity in vitro.
Topics: Adenocarcinoma; Animals; Carrier Proteins; Cell Division; Chromatography, Gel; Colonic Neoplasms; Floxuridine; Folic Acid; Humans; Leucovorin; Leukemia L1210; Tetrahydrofolates | 1990 |
Continuous intrahepatic infusion of floxuridine and leucovorin through an implantable pump for the treatment of hepatic metastases from colorectal carcinoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoembryonic Antigen; Colorectal Neoplasms; Floxuridine; Humans; Infusion Pumps; Leucovorin; Liver; Liver Neoplasms | 1990 |
Relationship between dose rate of [6RS]Leucovorin administration, plasma concentrations of reduced folates, and pools of 5,10-methylenetetrahydrofolates and tetrahydrofolates in human colon adenocarcinoma xenografts.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Female; Floxuridine; Half-Life; Humans; Injections, Intravenous; Leucovorin; Mice; Mice, Inbred CBA; Tetrahydrofolates; Thymidylate Synthase; Time Factors | 1990 |
Modulation of fluoropyrimidines by pretreatment with antifolates or folinic acid (leucovorin).
Topics: Antineoplastic Combined Chemotherapy Protocols; Drug Synergism; Floxuridine; Fluorouracil; Humans; Leucovorin; Methotrexate; Neoplasms | 1990 |
Enhancement of fluorinated pyrimidine-induced cytotoxicity by leucovorin in human lung cancer cell lines.
Topics: Adenocarcinoma; Adenocarcinoma, Bronchiolo-Alveolar; Carcinoma, Squamous Cell; Cell Line; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug Synergism; Floxuridine; Fluorouracil; Humans; Leucovorin; Lung Neoplasms; Tumor Cells, Cultured | 1990 |
A phase I clinical trial of combined fluoropyrimidines with leucovorin in a 14-day infusion. Demonstration of biochemical modulation.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Diarrhea; Drug Administration Schedule; Drug Evaluation; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Neoplasms; Remission Induction; Stomatitis | 1989 |
Modulation of 5-fluoro-2'-deoxyuridine response by folinic acid in human colonic tumor cell lines: the role of thymidylate synthase.
Topics: Cell Division; Colonic Neoplasms; Floxuridine; Humans; In Vitro Techniques; Leucovorin; Pteroylpolyglutamic Acids; Thymidylate Synthase; Tumor Cells, Cultured | 1989 |
Stability of floxuridine and leucovorin calcium admixtures for intraperitoneal administration.
Topics: Chromatography, High Pressure Liquid; Drug Combinations; Drug Stability; Drug Storage; Floxuridine; Injections, Intraperitoneal; Leucovorin; Temperature | 1989 |
[Two cases of gastrointestinal cancers with major responses to sequential methotrexate 5-FU plus 5'-DFUR].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carcinoembryonic Antigen; Colonic Neoplasms; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Lymphatic Metastasis; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Remission Induction; Stomach Neoplasms | 1989 |
Enhancement of fluoropyrimidine inhibition of cell growth by leucovorin and deoxynucleosides in a human squamous cell carcinoma cell line.
Topics: Carcinoma, Squamous Cell; Culture Media; Deoxyribonucleosides; Drug Synergism; Floxuridine; Fluorouracil; Humans; Leucovorin; Tumor Cells, Cultured | 1989 |
Folinic acid augmentation of the effects of fluoropyrimidines on murine and human leukemic cells.
Topics: Animals; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Floxuridine; Fluorouracil; Folic Acid; Humans; Leucovorin; Leukemia; Leukemia L1210; Mice | 1986 |
The effects on 4-aminoantifolates on 5-formyltetrahydrofolate metabolism in L1210 cells. A biochemical basis of the selectivity of leucovorin rescue.
Topics: Adenosine; Animals; Cell Division; Floxuridine; Folic Acid; Kinetics; Leucovorin; Leukemia L1210; Mice; Thymidine | 1987 |
Cytotoxicity of floxuridine and 5-fluorouracil in human T-lymphoblast leukemia cells: enhancement by leucovorin.
Topics: Cell Division; Cell Line; Cell Survival; Drug Synergism; Floxuridine; Fluorouracil; Humans; Leucovorin; Leukemia, Lymphoid; T-Lymphocytes; Thymidine | 1987 |
Biochemical rationale for the synergism of 5-fluorouracil and folinic acid.
Topics: Animals; Cell Division; Cell Survival; Deoxyuracil Nucleotides; Drug Synergism; Floxuridine; Fluorouracil; Hydroxyurea; Leucovorin; Leukemia L1210; Mice; Structure-Activity Relationship; Tumor Cells, Cultured | 1987 |
Increased levels of DNA lesions induced by leucovorin-5-fluoropyrimidine in human colon adenocarcinoma.
Topics: Adenocarcinoma; Aphidicolin; Cell Line; Cell Survival; Colonic Neoplasms; Diterpenes; DNA; DNA Damage; Drug Synergism; Floxuridine; Fluorouracil; Humans; Leucovorin; Pyrimidines; Thymidine | 1988 |
Mechanism of the cytotoxic synergism of fluoropyrimidines and folinic acid in mouse leukemic cells.
Topics: Animals; Cell Survival; Drug Synergism; Floxuridine; Fluorouracil; Kinetics; Leucovorin; Leukemia L1210; Mice; Thymidylate Synthase | 1988 |
Enhancement of fluorinated pyrimidine-induced cytotoxicity by leucovorin in human colorectal carcinoma cell lines.
Topics: Carcinoma; Cell Survival; Colorectal Neoplasms; Drug Synergism; Floxuridine; Fluorouracil; Humans; Leucovorin; Tumor Cells, Cultured | 1988 |
The role of thymidylate synthase in the response to fluoropyrimidine-folinic acid combinations.
Topics: Cell Line; Clone Cells; Colorectal Neoplasms; Drug Resistance; Floxuridine; Humans; Leucovorin; Thymidylate Synthase; Tumor Cells, Cultured | 1988 |
Tumor cell responses to inhibition of thymidylate synthase.
Topics: Animals; Cell Line; Cell Survival; Drug Screening Assays, Antitumor; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Kinetics; Leucovorin; Protein Binding; Thymidylate Synthase; Tumor Cells, Cultured | 1988 |
Intra-arterial infusion--an adjuvant to the treatment of oral carcinoma.
Topics: Adult; Aged; Carotid Artery, External; Catheterization; Evaluation Studies as Topic; Floxuridine; Fluorouracil; Gingival Neoplasms; Humans; Injections, Intra-Arterial; Leucovorin; Lip Neoplasms; Methotrexate; Middle Aged; Mouth Neoplasms; Palatal Neoplasms; Palliative Care | 1972 |
The effect of treatment with cytotoxic agents on mouse spleen dihydrofolate reductase activity.
Topics: Animals; Cyclophosphamide; Floxuridine; Folic Acid; In Vitro Techniques; Leucovorin; Male; Methotrexate; Mice; Nucleosides; Organ Size; Spleen; Tetrahydrofolate Dehydrogenase; Thymidine | 1967 |
[Experience with non-surgical treatment of brain tumors at the authors' department].
Topics: Adenoma, Chromophobe; Adolescent; Adult; Aged; Brain Neoplasms; Child; Child, Preschool; Cobalt Isotopes; Female; Floxuridine; Folic Acid; Glioma; Humans; Infusions, Parenteral; Leucovorin; Male; Methotrexate; Middle Aged; Radioisotope Teletherapy | 1967 |
Effect of folinate on thymidine uptake by Pediococcus cerevisiae.
Topics: Aminopterin; Carbon Isotopes; Deoxyuridine; Floxuridine; Glucose; Hydrogen-Ion Concentration; Iodoacetates; Leucovorin; Methotrexate; Pediococcus; Temperature; Thymidine; Thymine; Tritium; Uracil | 1968 |
Mode of action of methotrexate upon insulin-antibody formation in guinea pigs.
Topics: Adenosine; Animals; Antibody Formation; Deoxyadenosines; Depression, Chemical; Drug Antagonism; Floxuridine; Formates; Guanosine; Guinea Pigs; Immunization; Immunosuppressive Agents; Insulin Antibodies; Iodine Isotopes; Leucovorin; Male; Mathematics; Methotrexate; Swine; Tetrahydrofolates; Thymidine; Time Factors | 1972 |
Intra-arterial infusion in tumors of the pelvis.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Floxuridine; Fluorouracil; Humans; Iliac Artery; Infusions, Intra-Arterial; Leucovorin; Male; Melanoma; Methotrexate; Middle Aged; Ovarian Neoplasms; Pelvic Neoplasms; Prostatic Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms | 1983 |
[Augmentation of chemotherapeutic efficaciousness of UFT by oral l-leucovorin--growth-inhibitory activity of combination against human tumor xenograft].
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Female; Floxuridine; Humans; Leucovorin; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Tegafur; Transplantation, Heterologous; Uracil | 1995 |
A phase I trial of immediate postoperative intraperitoneal floxuridine and leucovorin plus systemic 5-fluorouracil and levamisole after resection of high risk colon cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Clinical Trials, Phase I as Topic; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; Leucovorin; Levamisole | 1995 |
[The evolution of the liver metastases from colorectal carcinoma treated with hepatic intra-arterial chemotherapy. The echographic and CT aspects].
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Colorectal Neoplasms; Floxuridine; Fluorouracil; Follow-Up Studies; Humans; Infusions, Intra-Arterial; Italy; Leucovorin; Liver; Liver Neoplasms; Remission Induction; Retrospective Studies; Tomography, X-Ray Computed; Ultrasonography | 1994 |
[Adjuvant regional chemotherapy after resection of liver metastases of primary colorectal tumors].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Combined Modality Therapy; Female; Floxuridine; Follow-Up Studies; Humans; Infusion Pumps; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Male; Middle Aged; Survival Rate | 1993 |
Role of fluoropyrimidine Schedule and (6R,S)leucovorin dose in a preclinical animal model of colorectal carcinoma.
Topics: Animals; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Leucovorin; Rats; Rats, Inbred F344; Time Factors | 1996 |
Oral chemotherapy with doxifluridine and folinic acid in biliary tract cancer.
Topics: Adult; Aged; Antidotes; Antineoplastic Agents; Biliary Tract Neoplasms; Drug Therapy, Combination; Female; Floxuridine; Humans; Leucovorin; Male; Middle Aged | 1995 |
Biological properties of fluoroglutamate-containing analogs of folates and methotrexate with altered capacities to form poly (gamma-glutamate) metabolites.
Topics: Animals; Cell Division; Floxuridine; Folic Acid; Growth Inhibitors; Growth Substances; Humans; Leucovorin; Methotrexate; Polyglutamic Acid; Rats; Tumor Cells, Cultured | 1996 |
Mechanisms of acquired resistance to modulation of 5-fluorouracil by leucovorin in HCT-8 human ileocecal carcinoma cells.
Topics: Antimetabolites, Antineoplastic; Drug Resistance; Floxuridine; Fluorouracil; Humans; Leucovorin; Thymidylate Synthase; Tumor Cells, Cultured | 1997 |
Chemoradiotherapy as preoperative treatment in locally advanced unresectable pancreatic cancer patients: results of a feasibility study.
Topics: Adult; Aged; Antidotes; Antineoplastic Agents; Combined Modality Therapy; Disease Progression; Feasibility Studies; Female; Floxuridine; Humans; Leucovorin; Male; Middle Aged; Neoplasm Staging; Pancreatectomy; Pancreatic Neoplasms; Survival Rate | 1999 |
[A case of recurrent breast cancer with carcinoma erysipeloides responding to sequential therapy with docetaxel (TXT) and doxifluridine (5'-DFUR) accompanied by leucovorin (LV)].
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma; Cyclophosphamide; Docetaxel; Doxorubicin; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Injections, Intra-Arterial; Leucovorin; Mastectomy; Middle Aged; Neoplasm Recurrence, Local; Paclitaxel; Skin Neoplasms; Taxoids | 2000 |
Hepatic arterial infusion of chemotherapy for metastatic colorectal cancer.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Data Interpretation, Statistical; Disease-Free Survival; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Survival Rate | 2000 |
Intra-abdominal fibrosis after systemic and intraperitoneal therapy containing fluoropyrimidines.
Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Female; Fibrosis; Floxuridine; Humans; Infusions, Parenteral; Leucovorin; Middle Aged; Peritoneum | 2000 |
Escherichia coli thymidylate synthase expression protects human cells from the cytotoxic effects of 5-fluorodeoxyuridine more effectively than human thymidylate synthase overexpression.
Topics: Cell Line; Escherichia coli; Floxuridine; Gene Expression; Humans; Leucovorin; Species Specificity; Thymidylate Synthase | 2000 |
Surrogate endpoints for new colorectal cancer drugs.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Leucovorin; Methotrexate; Randomized Controlled Trials as Topic; Survival Analysis | 2000 |
Sequential intrahepatic and systemic fluoropyrimidine-based chemotherapy for metastatic colorectal cancer confined to the liver. A phase II study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease-Free Survival; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Male; Middle Aged; Survival Rate; Treatment Outcome | 2001 |
Surgery as adjuvant therapy? The treatment of peritoneal metastases from gastrointestinal malignancy.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Appendiceal Neoplasms; Colonic Neoplasms; Combined Modality Therapy; Floxuridine; Formyltetrahydrofolates; Humans; Infusions, Parenteral; Leucovorin; Peritoneal Neoplasms; Survival Rate | 2001 |
Surgical debulking and intraperitoneal chemotherapy for established peritoneal metastases from colon and appendix cancer.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Appendiceal Neoplasms; Colonic Neoplasms; Combined Modality Therapy; Female; Floxuridine; Formyltetrahydrofolates; Humans; Infusions, Parenteral; Leucovorin; Male; Middle Aged; Peritoneal Neoplasms; Retrospective Studies; Survival Analysis | 2001 |
CANCER CHEMOTHERAPY BY CONTINUOUS INTRA-ARTERIAL INFUSION. EXPERIENCE OF THE VETERANS ADMINISTRATION SURGICAL ADJUVANT CANCER CHEMOTHERAPY INFUSION STUDY GROUP.
Topics: Floxuridine; Geriatrics; Hemiplegia; Hemorrhage; Infusions, Intra-Arterial; Infusions, Parenteral; Leucovorin; Mechlorethamine; Methotrexate; Mortality; Neoplasms; Thiotepa; Toxicology; United States; United States Department of Veterans Affairs | 1964 |
[A case of hepatic metastasis and local recurrence from rectal cancer responding to hepatic arterial infusion and systemic chemotherapy].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Drug Administration Schedule; Drug Combinations; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Irinotecan; Leucovorin; Liver Neoplasms; Male; Neoplasm Recurrence, Local; Rectal Neoplasms; Tegafur; Uracil | 2003 |
[A case of disseminated tumor from cecal cancer with survival for over 5 years after twice surgical resection and systemic chemotherapy].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoembryonic Antigen; Cecal Neoplasms; Combined Modality Therapy; Floxuridine; Fluorouracil; Humans; Irinotecan; Leucovorin; Male; Neoplasm Seeding; Peritoneal Neoplasms; Reoperation | 2004 |
Improved survival and response to hepatic infusion.
Topics: Combined Modality Therapy; Dexamethasone; Floxuridine; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Survival; Treatment Outcome | 2006 |
Endoscopic ultrasound restaging after neoadjuvant chemotherapy in esophageal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Docetaxel; Endosonography; Esophageal Neoplasms; Female; Floxuridine; Humans; Leucovorin; Lymph Nodes; Male; Neoadjuvant Therapy; Neoplasm Staging; Proportional Hazards Models; Retrospective Studies; Survival Analysis; Taxoids | 2006 |
[A case of colon cancer liver metastases treated by combined therapies].
Topics: Antineoplastic Combined Chemotherapy Protocols; Catheter Ablation; Chemotherapy, Adjuvant; Colon, Sigmoid; Combined Modality Therapy; Floxuridine; Fluorouracil; Hepatectomy; Humans; Jaundice, Obstructive; Leucovorin; Liver Neoplasms; Lymph Node Excision; Male; Middle Aged; Sigmoid Neoplasms; Stents; Tegafur | 2006 |
Assessing the optimal duration of chemotherapy in patients with colorectal liver metastases.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Dexamethasone; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intra-Arterial; Irinotecan; Leucovorin; Liver Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Retrospective Studies; Time Factors; Treatment Outcome | 2008 |
Hepatic arterial infusion for unresectable colorectal liver metastases combined or not with systemic chemotherapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cohort Studies; Colorectal Neoplasms; Dexamethasone; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Male; Middle Aged; Retrospective Studies; Survival Rate; Treatment Outcome | 2009 |
In defense of hepatic arterial infusion for hepatic metastases of colorectal cancer.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Dexamethasone; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Survival Analysis; United States | 2010 |
Selective intra-arterial chemotherapy with floxuridine as second- or third-line approach in patients with unresectable colorectal liver metastases.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cohort Studies; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Follow-Up Studies; Hepatic Artery; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Organoplatinum Compounds; Oxaliplatin; Prospective Studies; Retrospective Studies; Survival Rate; Treatment Outcome | 2011 |
Postoperative intraperitoneal 5-fluoro-2'-deoxyuridine added to chemoradiation in patients curatively resected (R0) for locally advanced gastric and gastroesophageal junction adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Combined Modality Therapy; Esophagogastric Junction; Feasibility Studies; Female; Floxuridine; Fluorouracil; Follow-Up Studies; Gastrectomy; Humans; Leucovorin; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Pilot Projects; Postoperative Period; Prognosis; Radiotherapy Dosage; Stomach Neoplasms; Survival Rate | 2012 |
Early postoperative intraperitoneal chemotherapy following cytoreductive surgery for appendiceal mucinous neoplasms with isolated peritoneal metastasis.
Topics: Adenocarcinoma, Mucinous; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Appendiceal Neoplasms; Combined Modality Therapy; Disease Progression; Drug Administration Schedule; Female; Floxuridine; Humans; Infusions, Parenteral; Leucovorin; Male; Middle Aged; Neoplasm Recurrence, Local; Peritoneal Neoplasms; Retrospective Studies; Survival Analysis; Treatment Outcome | 2012 |
Flaviviruses are sensitive to inhibition of thymidine synthesis pathways.
Topics: Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Dengue Virus; Disease Models, Animal; DNA Viruses; Flavivirus; Flavivirus Infections; Floxuridine; HEK293 Cells; HeLa Cells; Humans; Leucovorin; Methotrexate; Mice; Mice, 129 Strain; Mice, Inbred C57BL; RNA Viruses; Thymidine; Tumor Suppressor Protein p53; Vero Cells; Virus Replication; West Nile virus | 2013 |
Updated long-term survival for patients with metastatic colorectal cancer treated with liver resection followed by hepatic arterial infusion and systemic chemotherapy.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Colorectal Neoplasms; Dexamethasone; Disease-Free Survival; Female; Floxuridine; Fluorouracil; Follow-Up Studies; Hepatectomy; Humans; Infusions, Intra-Arterial; Irinotecan; Leucovorin; Liver Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Survival Rate; Young Adult | 2016 |
Utilizing the various forms of the gastrocnemius muscle in fix & flap protocol: a reliable remedy for open proximal tibial fractures with accompanying soft tissue defect.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Doxorubicin; Floxuridine; Fractures, Open; Humans; Leucovorin; Muscle, Skeletal; Plastic Surgery Procedures; Retrospective Studies; Soft Tissue Injuries; Tibia; Tibial Fractures; Treatment Outcome | 2022 |