floxuridine has been researched along with deoxyuridine in 137 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 89 (64.96) | 18.7374 |
| 1990's | 9 (6.57) | 18.2507 |
| 2000's | 5 (3.65) | 29.6817 |
| 2010's | 27 (19.71) | 24.3611 |
| 2020's | 7 (5.11) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, MS; Prusoff, WH; Schinazi, RF | 1 |
| Meyer, RB; Nakayama, C; Saneyoshi, M; Santi, DV; Ueda, T; Wataya, Y | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Agrawal, B; Kumar, R; Mak, M; Srivastav, NC; Tyrrell, DL | 1 |
| Poirier, LA; Shimkin, MB; Stoner, GD | 1 |
| Mathews, CK | 1 |
| Grunden, EE; Jato, JG; Johnson, BM; Lake, LM | 1 |
| Gamble, J; Miller, JF; Vadas, MA; Whitelaw, A | 1 |
| Groth, DP; Kinkade, JM; Ross, DD | 1 |
| Roberts, D; Warmath, EV | 1 |
| Bryan, AM; Lau, K; Olafsson, PG | 1 |
| Schluter, DN; Wigler, PW | 1 |
| Pfefferkorn, ER; Pfefferkorn, LC | 1 |
| Biermann, WA; Haurani, FI; Kardinal, CG | 1 |
| Beránek, J; Hrebabecký, H | 1 |
| Bowen, D; Diasio, RB; Goldman, ID | 1 |
| Baker, PN; Bradshaw, TK; Burke, DC; Morser, J | 1 |
| Parsons, PG; Smellie, SG | 1 |
| Boynton, AL; MacManus, JP; Rixon, RH; Swierenga, S; Whitfield, JF; Youdale, T | 1 |
| Allen, TM; Knaus, EE; Kumar, R; Tempest, ML; Wiebe, LI | 1 |
| Goldman, ID; Rape, TJ; Seither, RL | 1 |
| Chen, ZH; Chu, E; Chu, MY; Chu, SH; Darnowski, JW; Pan, BC | 1 |
| Saneyoshi, M | 1 |
| Cory, JG; Halley, MC; Jeney, A; Lapis, K | 1 |
| Kaysen, J; Kufe, D; Spriggs, D | 1 |
| Goldman, ID; Mikulecky, DC; Rape, TJ; Seither, RL; Trent, DF | 1 |
| De Clercq, E; Griengl, H; Rosenwirth, B; Schwarz, W; Streicher, W; Wanek, E | 2 |
| Abrams, DN; Knaus, EE; Lee, YW; Mercer, JR; Wiebe, LI | 1 |
| Alison, DL; Calvert, AH; Harrap, KR; Jackman, AL | 1 |
| Brubaker, WF; Lin, TS; Park, S; Prusoff, WH; Wang, ZH | 1 |
| Fischer, PH; Grem, JL | 1 |
| FitzGerald, GB; Ratliff, J; Wick, MM | 1 |
| Kalman, TI; Yalowich, JC | 1 |
| De Vrye, CE; Fahmy, MJ; Fahmy, OG | 1 |
| Neuhard, J | 1 |
| Foley, GE; Lazarus, H | 1 |
| Bresnick, E; Williams, SS | 1 |
| Grossowicz, N; Mandelbaum-Shavit, F | 1 |
| Heidelberger, C; Umeda, M | 2 |
| Bastos, A; Correia, D; Marques, D; Nunes, J; Silva, F; Terrinha, A; Vigário, J | 1 |
| Carley, JG; Standfast, HA | 1 |
| Rahman, A; Wilson, HR | 1 |
| Coyle, M; McMahon, M; Strauss, B | 1 |
| Ansfield, FJ; Ramirez, G | 1 |
| Bruns, R; Hall, TC; Kessel, D | 1 |
| Chang, PK; Prusoff, WH; Voytek, P | 1 |
| Moner, JG; Plunkett, W | 1 |
| Beck, CF; Ingraham, JL; Neuhard, J; Thomassen, E | 1 |
| Jato, J; Windheuser, JJ | 2 |
| Beck, A; Tan, YL | 1 |
| Painter, RB | 1 |
| Chabner, BA; Johns, DG; Myers, CE; Young, RC | 1 |
| Ohyama, K | 1 |
| Bryan, AM; Olafsson, PG | 1 |
| Clarkson, BD; Duschinsky, R; Keller, O; Krakoff, IH; La Sala, E; Van Dyk, JJ | 1 |
| Herrmann, EC | 1 |
| Maley, F; Maley, GF | 1 |
| Altshtein, AD; Avakyan, AA; Ciampor, F; Nadtochey, GA; Omelchenko, TN | 1 |
| Bowen, D; Gewirtz, DA; Goldman, D | 1 |
| Cadman, E; Grant, S | 1 |
| Gati, WP; Knaus, EE; Wiebe, LI | 1 |
| Bailey, BD; Bowen, D; Guernsey, LA | 1 |
| Beck, WS; Pelliniemi, TT | 1 |
| Cook, AF; Holman, MJ; Kramer, MJ | 1 |
| Bowen, D; Fölsch, E; Guernsey, LA | 1 |
| Baugh, CM; Gaumont, Y; Kisliuk, RL; Lafer, E; Montgomery, JA | 1 |
| Iwai, S; Kataoka, S; Nakamura, H; Ohtsuka, E; Wakasa, M | 1 |
| Maeda, M; Saneyoshi, M; Tokuzen, R; Yamaguchi, T; Yoshida, M | 1 |
| Baldwin, RW; Bycroft, BW; Chhabra, SR; Garnett, MC; Henn, TF | 1 |
| Harada, N; Hashiyama, T; Hongu, M; Kawaguchi, T; Oda, K; Ohohashi, M; Tsujihara, K | 1 |
| ANSFIELD, FJ | 1 |
| JOHNSON, AG; MERRITT, K | 2 |
| LOVE, R; STUDZINSKI, GP | 1 |
| BIRNIE, GD; BOOHAR, J; HEIDELBERGER, C; WENTLAND, D | 1 |
| LINDENMANN, J | 1 |
| SHEININ, R | 1 |
| BOND, SB; KRISS, JP | 1 |
| RUSCH, HP; SACHSENMAIER, W | 1 |
| DUBBS, DR; KIT, S | 1 |
| LOH, PC; PAYNE, FE | 1 |
| GHOBAR, A; GRIESBACH, L; HEIDELBERGER, C | 1 |
| CURRERI, AR; JOHNSON, RO; WOLBERG, WH | 1 |
| Otvös, L; Sági, G | 1 |
| Eriksson, S; Wang, L; Wehelie, R | 1 |
| Collier, G; Gaballah, ST; Netzel, TL | 1 |
| Barnard, DL; Humphreys, DE; Hurst, BL; Smee, DF | 1 |
| Benyumov, A; Gurvich, VJ; Kirstein, MN; Lis, LG; Williams, BW | 1 |
| Lee, LB; Ruterbories, KJ; Schmalz, CA; Torchia, J; Wickremsinhe, ER | 1 |
| Dietzel, ID; Haak, A; Klapal, L; Lesslich, HM; Wilke, J | 1 |
| CRUZ, O; GRIESBACH, L; GRUNBERG, E; HEIDELBERGER, C; SCHNITZER, RJ | 1 |
| BOLAFFI, JL; CHEONG, L; EIDINOFF, ML; KNOLL, JE; RICH, MA | 1 |
| EIDINOFF, ML; RICH, MA | 1 |
| ANSFIELD, FJ; CURRERI, AR | 2 |
| BURCHENAL, JH; CLARKSON, B; GLATSTEIN, N; MILLER, E; SULLIVAN, RD; YOUNG, CW | 1 |
| BURCHENAL, JH; ELLISON, RR; ESCHER, G; KARNOFSKY, DA; KAUFMAN, R; LEVICK, SN; LI, MC; MILLER, E; SULLIVAN, RD; WOLDOW, I; YOUNG, CW | 1 |
| ANSFIELD, FJ; CURRERI, AR; SCHROEDER, JM | 1 |
| NICHOL, CA; WHITE, PJ | 1 |
| ERLANDSON, M; HARTMANN, JR; MURPHY, ML; ORIGENES, ML; SITARZ, A | 1 |
| KOIKE, A; MOORE, GE | 1 |
| COLLOM, A; JACOBS, E; PAPAC, R; SKOOG, W; WONG, F; WOOD, DA | 1 |
| HAGIWARA, A; PAUL, J | 1 |
| Jain, HV; Kalman, TI | 1 |
| Hack, A; Königsrainer, A; Küper, M; Schott, TC; Struller, F; Weinreich, J | 1 |
| Chen, TM; Chu, E; Gmeiner, WH; Schmitz, JC; Wu, SY | 1 |
| Morgenroth, A; Mottaghy, FM; Oedekoven, C; Siluschek, M; Vogg, AT; Zlatopolskiy, BD | 1 |
| Anbalagan, C; Bodhicharla, R; González-Hunt, CP; Luz, AL; Meyer, JN; Rooney, JP; Ryde, IT | 1 |
| Badr, G; Ishtikhar, M; Khan, RH; Khan, S; Osama Mohamed, A | 1 |
| Hahn, U; Kruspe, S | 1 |
| Ando, K; Iimori, M; Kiniwa, M; Kitao, H; Kiyonari, S; Maehara, Y; Matsuoka, K; Niimi, S; Oki, E; Saeki, H; Tokunaga, E; Tsukihara, H; Watanabe, S | 1 |
| Dua, P; Kim, S; Lee, DK; S, S | 1 |
| Gero, AM; Lutze-Mann, LH; Murray, V; Taylor, CB | 1 |
| Beijnen, JH; Derissen, EJ; Huitema, AD; Jacobs, BA; Rosing, H; Schellens, JH | 1 |
| Barciszewski, J; Boryski, J; Framski, G; Kraszewski, A; Kujda, M; Stawinski, J; Szymańska-Michalak, A; Wawrzyniak, D; Zgoła, P | 1 |
| Chang, J; Jiang, J; Kang, J; Li, E; Li, L; Liu, B; Peng, Y; Wang, Q; Wang, Y; Wu, J; Yang, Q; Yu, W; Zhang, J | 1 |
| Hiramoto, A; Kim, HS; Masutani, M; Omi, T; Satake, A; Sato, A; Tanuma, S; Wataya, Y; Yamamoto, A | 1 |
| Celewicz, L; Chojnacka, K; Hoffmann, M; Kacprzak, K; Kleczewska, N; Lewandowska, M; Ruszkowski, P | 1 |
| Beumer, JH; Eiseman, JL; Holleran, JL; Kummar, S; Parise, RA | 1 |
| Kato, Y; Miyaji, M; Zhang-Akiyama, QM | 1 |
| Andersen, EC; García-González, AP; Ritter, AD; Shrestha, S; Walhout, AJM; Yilmaz, LS | 1 |
| Gmeiner, WH; Melvin, RL; Salsbury, FR | 1 |
| Sato, A | 1 |
| Allen, PJ; Balachandran, VP; Boucher, T; Capanu, M; Cercek, A; Chou, JF; D'Angelica, MI; DeMatteo, RP; Jarnagin, WR; Kemeny, NE; Kingham, TP; Pak, LM | 1 |
| Aviñó, A; Eritja, R; Fàbrega, C; Jorge, AF; Pais, AACC | 1 |
| Bell, M; Hanessian, S; Rico, L; Seth, PP; Østergaard, ME | 1 |
| Burnaevskiy, N; Chen, S; Kaeberlein, M; Karanth, S; Mailig, M; Mendenhall, A; Reynolds, A; Van Gilst, M | 1 |
| Gupta, U; Hira, SK; Manna, PP; Paladhi, A; Singh, R; Singh, RA; Srivastava, DN; Srivastava, P | 1 |
| Baumanns, S; Dilberger, B; Eckert, GP; Spieth, ST; Wenzel, U | 1 |
| Aziz, MY; Azizi, J; Kamaruzaman, S; Keyon, ASA; Mohamad Zain, NN; Noordin, SS; Saad, B; Semail, NF; Waras, MN; Yahaya, N | 1 |
| Clua, A; Eritja, R; Fàbrega, C; García-Chica, J; Grijalvo, S | 1 |
| Hira, SK; Manna, PP; Paladhi, A; Singh, R; Singh, RA; Srivastava, DN; Srivastava, P | 1 |
| Cui, S; Jiang, L; Liu, X; Luo, D; Lv, Q; Pan, T; Qu, X; Wan, S; Yuan, W | 1 |
5 review(s) available for floxuridine and deoxyuridine
| Article | Year |
|---|---|
Radiation sensitizers.
Topics: Animals; Antineoplastic Agents; Bromodeoxycytidine; Bromodeoxyuridine; Carcinoma; Deoxyuridine; Dogs; Dose-Response Relationship, Radiation; Floxuridine; Humans; Hypoxia; Idoxuridine; Lung Neoplasms; Methotrexate; Metronidazole; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Research; Sarcoma, Experimental; Skin | 1976 |
The positive control of cell proliferation by the interplay on calcium ions and cyclic nucleotides. A review.
Topics: Acetylcholine; Animals; Bucladesine; Calcium; Cell Division; Cell Line; Concanavalin A; Cyclic AMP; Cyclic GMP; Deoxyuridine; DNA; Floxuridine; Growth Hormone; Humans; Liver; Lymphocyte Activation; Models, Biological; Parathyroid Hormone; Pindolol; Prostaglandins; Rats; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymidine; Thymidine Monophosphate | 1976 |
The action of ultraviolet light on mammalian cells.
Topics: Animals; Bromodeoxyuridine; Cell Division; Cells, Cultured; Chlorides; Chromosome Aberrations; Cricetinae; Deoxyuridine; DNA Repair; DNA Replication; Floxuridine; Humans; Iodides; Metabolism; Mice; Microchemistry; Mitosis; Protein Biosynthesis; Radiation Effects; RNA; Swine; Time Factors; Tritium; Ultraviolet Rays | 1970 |
Some considerations in the experimental approach to distinguishing between membrane transport and intracellular disposition of antineoplastic agents, with specific reference to fluorodeoxyuridine, actinomycin D, and methotrexate.
Topics: Animals; Antineoplastic Agents; Biological Transport; Biotransformation; Cell Membrane; Dactinomycin; Deoxyuridine; Floxuridine; Humans; Kinetics; Liver; Methotrexate; Polyglutamic Acid; Tritium | 1981 |
[Novel Anticancer Strategy Targeting Switch Mechanisms in Two Types of Cell Death: Necrosis and Apoptosis].
Topics: Activating Transcription Factor 3; Animals; Antineoplastic Agents; Apoptosis; Benzoquinones; Deoxyuridine; Gene Expression Profiling; HSP90 Heat-Shock Proteins; Lactams, Macrocyclic; Lamin Type B; Mice; MicroRNAs; Molecular Targeted Therapy; Necrosis; Neoplasms, Experimental | 2017 |
1 trial(s) available for floxuridine and deoxyuridine
| Article | Year |
|---|---|
Prospective phase II trial of combination hepatic artery infusion and systemic chemotherapy for unresectable colorectal liver metastases: Long term results and curative potential.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colorectal Neoplasms; Deoxyuridine; Disease-Free Survival; Female; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Irinotecan; Leucovorin; Liver Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Prospective Studies; Survival Rate; Treatment Outcome | 2018 |
131 other study(ies) available for floxuridine and deoxyuridine
| Article | Year |
|---|---|
Synthesis and biological activities of some uronic acids, uronates, uronamides, and urononitriles of pyrimidine nucleosides.
Topics: Animals; Cell Division; Cells, Cultured; Chick Embryo; Pyrimidine Nucleosides; Sarcoma 180; Simplexvirus; Streptococcus; Structure-Activity Relationship; Substrate Specificity; Thymidine Kinase; Thymidylate Synthase; Uronic Acids; Virus Replication | 1978 |
Thymidine phosphorylase. Substrate specificity for 5-substituted 2'-deoxyuridines.
Topics: Animals; Deoxyuridine; Horses; In Vitro Techniques; Models, Biological; Pentosyltransferases; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Substrate Specificity; Thymidine Phosphorylase | 1980 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Antiviral activity of 2,3'-anhydro and related pyrimidine nucleosides against hepatitis B virus.
Topics: Antiviral Agents; Hepatitis B virus; Pyrimidine Nucleosides | 2010 |
Bioassay of alkyl halides and nucleotide base analogs by pulmonary tumor response in strain A mice.
Topics: Adenoma; Alkanes; Animals; Biological Assay; Bromodeoxyuridine; Carcinogens; Deoxyuridine; Female; Floxuridine; Halogens; Idoxuridine; Lung Neoplasms; Male; Mice; Mice, Inbred A; Neoplasms, Experimental | 1975 |
Effects of thymidine analogs upon growth control in cultured hormone-dependent ray ovary cells.
Topics: Animals; Bromodeoxyuridine; Cell Differentiation; Cell Division; Cell Line; Cell Survival; Culture Media; Cytarabine; Deoxyuridine; DNA; Female; Floxuridine; Hormones; Hydroxyurea; Idoxuridine; Kinetics; Ovarian Neoplasms; Rats; Thymidine | 1975 |
Effect of deoxyuridine coadministration on toxicity and antitumor activity of fluorouracil and floxuridine.
Topics: Animals; Antineoplastic Agents; Biological Assay; Deoxyuridine; Drug Combinations; Drug Synergism; Female; Floxuridine; Fluorouracil; Lethal Dose 50; Mice; Sarcoma 180; Skin Neoplasms | 1975 |
A radioisotopic method to measure delayed type hypersensitivity in the mouse. II. Cell transfer studies.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Chickens; Deoxyuridine; Dinitrofluorobenzene; Ear, External; Erythrocytes; Female; Floxuridine; Fluorescent Antibody Technique; Hypersensitivity, Delayed; Immunoglobulins; Injections, Intradermal; Injections, Intraperitoneal; Iodine Radioisotopes; Lymph Nodes; Male; Mice; Mice, Inbred AKR; Mice, Inbred CBA; Radiation Chimera; Spleen; T-Lymphocytes | 1975 |
Effects of urinary proteins from certain leukemics upon macromolecular synthesis and enzyme levels in bone marrow cultures.
Topics: Adenine Phosphoribosyltransferase; Amidophosphoribosyltransferase; Animals; Bone Marrow; Bone Marrow Cells; Cell Division; Cells, Cultured; Deoxyuridine; DNA; Female; Floxuridine; Humans; Leukemia; Male; Methotrexate; Mice; Mice, Inbred C57BL; Muramidase; Neoplasm Proteins; Proteinuria; RNA; Thymidine Kinase | 1975 |
Methotrexate inhibition of CCRF-CEM cultures of human lymphoblasts.
Topics: Cell Division; Cell Line; Deoxycytidine; Deoxyuridine; DNA, Neoplasm; Floxuridine; Folic Acid Antagonists; Humans; Hypoxanthines; Leucovorin; Leukemia, Lymphoid; Methotrexate; Purines; Thymidine | 1975 |
A differential scanning calorimetric-thin-layer chromatographic study of 5-halo-2'-deoxynucleosides.
Topics: Bromodeoxyuridine; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Deoxyuridine; Floxuridine; Idoxuridine; Uracil | 1976 |
Inhibition of membrane transport of 5-fluoro[6-3H]deoxyuridine into L5178Y mouse leukemia cells.
Topics: Animals; Biological Transport; Bromodeoxyuridine; Cell Line; Cell Membrane; Deoxyuridine; Floxuridine; Leukemia, Experimental; Thymidine Kinase; Tritium | 1976 |
Toxoplasma gondii: characterization of a mutant resistant to 5-fluorodeoxyuridine.
Topics: Animals; Cell Line; Deoxyuridine; DNA; Drug Resistance; Floxuridine; Fluorouracil; Genes; Mutation; RNA; Thymidine; Toxoplasma; Uridine | 1977 |
Thymidylate synthetase and dihydrofolic acid reductase in the stimulated human lymphocyte.
Topics: Cells, Cultured; Deoxyuridine; Floxuridine; Humans; Lectins; Lymphocytes; Methotrexate; Methyltransferases; Tetrahydrofolate Dehydrogenase; Thymidine; Thymidylate Synthase | 1978 |
5'-Halogeno-2',3'-cyclic sulphite isomers in the preparation of 5'-halogeno nucleosides. Synthesis of 5'-deoxyuridine and 5'-deoxy-5-fluorouridine.
Topics: Deoxyuridine; Floxuridine; Uridine | 1978 |
Distinguishing between membrane transport and intracellular metabolism of fluorodeoxyuridine in Ehrlich ascites tumor cells by application of kinetic and high performance liquid chromatographic techniques.
Topics: Animals; Biological Transport, Active; Carcinoma, Ehrlich Tumor; Cell Membrane; Chromatography, High Pressure Liquid; Deoxyuridine; Floxuridine; Fluorouracil; Kinetics; Mice; Thymidine; Uridine | 1979 |
The effect of 5-bromodeoxyuridine on interferon production in human cells.
Topics: Bromodeoxyuridine; Cell Division; Cell Line; Deoxycytidine; Deoxyuridine; DNA; Floxuridine; Humans; Idoxuridine; Interferons; Thymidine | 1979 |
Effects of thymidine analogues on murine and human cells.
Topics: Animals; Bromodeoxyuridine; Cell Count; Cell Line; Deoxyuridine; Fibroblasts; Floxuridine; Humans; Idoxuridine; Mice; Neoplasms; Neoplasms, Experimental; Thymidine | 1979 |
Synthesis, antiviral and cytotoxic activity of 2'-deoxyuridines, 2'-fluoro-2'-deoxyuridines and 2'-arabinouridines containing 5-(1-hydroxy-2-halo-2-ethoxycarbonylethyl)-, 5-(1-hydroxy-2-iodo-2- carboxyethyl)- and 5-[1-hydroxy (or methoxy)-2-iodoethyl] sub
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Arabinofuranosyluracil; Deoxyuridine; Floxuridine; Humans; KB Cells; Leukemia L1210; Leukemia P388; Mice; Simplexvirus; Structure-Activity Relationship; Tumor Cells, Cultured | 1992 |
Interconversion of tetrahydrofolate cofactors to dihydrofolate induced by trimetrexate after suppression of thymidylate synthase by fluorodeoxyuridine in L1210 leukemia cells.
Topics: Animals; Computer Simulation; Deoxyuridine; DNA; Enzyme Reactivators; Floxuridine; Folic Acid; Folic Acid Antagonists; Leucovorin; Leukemia L1210; Mice; Purines; Tetrahydrofolates; Thermodynamics; Thymidylate Synthase; Time Factors; Trimetrexate; Tumor Cells, Cultured | 1992 |
Enhancement of 5-fluoro-2'-deoxyuridine antineoplastic activity by 5-benzyloxybenzyloxybenzylacyclouridine in a human colon carcinoma cell line.
Topics: Antimetabolites, Antineoplastic; Cell Division; Cell Line; Colonic Neoplasms; Deoxyuridine; DNA Replication; Drug Synergism; Floxuridine; Humans; Kinetics; Recombinant Proteins; Thymidylate Synthase; Uracil; Uridine Monophosphate | 1992 |
[Enzyme inhibitors related to the nucleic acids biosynthesis and gene expression].
Topics: Animals; Chromatography, Affinity; Deoxyguanine Nucleotides; Deoxyuridine; DNA Repair; DNA Replication; DNA-Directed RNA Polymerases; Floxuridine; Mercaptopurine; Nucleic Acid Synthesis Inhibitors; RNA; RNA, Viral | 1991 |
5-Hexyl-2'-deoxyuridine blocks the cytotoxic effects of 5-fluorodeoxyuridine or deoxyadenosine in leukemia L1210 cells in culture.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Cell Survival; Deoxyadenosines; Deoxyuridine; Dose-Response Relationship, Drug; Floxuridine; Kinetics; Leukemia L1210; Mice; Tumor Cells, Cultured | 1990 |
Incorporation of 5-fluorodeoxycytidine and metabolites into nucleic acids of human MCF-7 breast carcinoma cells.
Topics: Azacitidine; Breast Neoplasms; Cell Line; Cell Survival; Decitabine; Deoxycytidine; Deoxyuridine; DNA, Neoplasm; Floxuridine; Humans; Methylation; RNA, Neoplasm; Tetrahydrouridine | 1986 |
Folate-pool interconversions and inhibition of biosynthetic processes after exposure of L1210 leukemia cells to antifolates. Experimental and network thermodynamic analyses of the role of dihydrofolate polyglutamylates in antifolate action in cells.
Topics: Animals; Computer Simulation; Deoxyuridine; Floxuridine; Folic Acid; Folic Acid Antagonists; Formates; Leukemia L1210; Methotrexate; Mice; Purines; Pyrimidines; Quinazolines; Tetrahydrofolates; Thermodynamics; Thymidylate Synthase; Trimetrexate | 1989 |
In vitro and in vivo antiviral activity of 2'-fluorinated arabinosides of 5-(2-haloalkyl)uracil.
Topics: Acyclovir; Animals; Antiviral Agents; Arabinofuranosyluracil; Cell Division; Cell Line; Chemical Phenomena; Chemistry; Deoxyuridine; DNA, Viral; Female; Floxuridine; Guinea Pigs; Herpes Simplex; Mice; Mice, Hairless; RNA, Viral; Simplexvirus; Virus Replication | 1987 |
Tumour uptake of radiolabelled pyrimidine bases and pyrimidine nucleosides in animal models. IX. Radiolabelled 1-(2'-fluoro-2'-deoxy-beta-D-ribofuranosyl)uracil and 1-(2'-chloro-2'-deoxy-beta-D-ribofuranosyl)uracil.
Topics: Animals; Carbon Radioisotopes; Carcinoma 256, Walker; Chlorine; Deoxyuridine; Floxuridine; Lung Neoplasms; Mice; Radioisotopes; Rats; Rats, Inbred Strains; Tissue Distribution; Uracil; Uridine | 1986 |
Increased thymidylate synthase in L1210 cells possessing acquired resistance to N10-propargyl-5,8-dideazafolic acid (CB3717): development, characterization, and cross-resistance studies.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Deoxyuridine; Drug Resistance; Floxuridine; Fluorouracil; Folic Acid; Folic Acid Antagonists; Hypoxanthine; Hypoxanthines; Kinetics; Leukemia L1210; Mice; Quinazolines; Thymidylate Synthase; Tritium | 1986 |
Antineoplastic activity of 3'-(chloroethyl)nitrosourea analogues of 2'-deoxyuridine and 2'-deoxy-5-fluorouridine.
Topics: Alkylation; Animals; Antineoplastic Agents; Deoxyuridine; Dideoxynucleosides; Female; Floxuridine; Leukemia L1210; Mice; Nitrosourea Compounds; Structure-Activity Relationship | 1986 |
Alteration of fluorouracil metabolism in human colon cancer cells by dipyridamole with a selective increase in fluorodeoxyuridine monophosphate levels.
Topics: Cells, Cultured; Colonic Neoplasms; Deoxyuracil Nucleotides; Deoxyuridine; Dipyridamole; DNA; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Ribonucleotides; Time Factors; Uridine Triphosphate | 1986 |
Inhibition of thymidylate synthase in intact L1210 cells by ara-C, daunomycin, hydroxyurea and 3,4-dihydroxybenzylamine.
Topics: Animals; Cytarabine; Daunorubicin; Deoxyuridine; DNA; Dopamine; Floxuridine; Hydroxyurea; Kinetics; Leukemia L1210; Methotrexate; Thymidylate Synthase | 1987 |
2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity.
Topics: Antiviral Agents; Bromodeoxyuridine; Deoxyuridine; Floxuridine; Simplexvirus; Structure-Activity Relationship | 1987 |
Rapid determination of thymidylate synthase activity and its inhibition in intact L1210 leukemia cells in vitro.
Topics: Animals; Cells, Cultured; Deoxycytidine; Deoxyuridine; Dose-Response Relationship, Drug; Floxuridine; Leukemia L1210; Methotrexate; Methyltransferases; Mice; Thymidylate Synthase; Tritium | 1985 |
The mutagenic properties of the nucleosides of pyrimidine analogues in Drosophila melanogaster.
Topics: Animals; Antimetabolites; Bromodeoxyuridine; Chromosome Aberrations; Chromosome Disorders; Cytarabine; Deoxyuridine; Drosophila; Floxuridine; Mutagens; Mutation; Nucleosides | 1966 |
Studies on the acid-soluble nucleotide pool in thymine-requiring mutants of Escherichia coli during thymine starvation. 3. On the regulation of the deoxyadenosine triphosphate and deoxycytidine triphosphate pools of Escherichia coli.
Topics: Adenosine Triphosphate; Arginine; Carbon Isotopes; Chromatography; Cytosine Nucleotides; Deoxyuridine; DNA, Bacterial; Escherichia coli; Floxuridine; Histidine; Methionine; Novobiocin; Nucleotides; Phosphorus Isotopes; Thymine; Uracil Nucleotides | 1966 |
The response in vitro, of continuous cultures of human lymphoblasts (CCRF-CEM cells) to chemotherapeutic agents.
Topics: Animals; Azaserine; Chloramphenicol; Culture Media; Culture Techniques; Cyclophosphamide; Cytarabine; Dactinomycin; Deoxyuridine; Floxuridine; Fluorouracil; Humans; Hydrocortisone; Lymphocytes; Mechlorethamine; Mercaptopurine; Methotrexate; Mitomycins; Puromycin; Thymidine; Triazines; Vincristine | 1967 |
Effects of 5-trifluoromethyldeoxyuridine upon deoxythymidine kinase.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Bromodeoxyuridine; Carbon Isotopes; Culture Media; Deoxyuridine; Floxuridine; Kinetics; Liver; Male; Nucleotides; Oxidative Phosphorylation; Rats; Thymidine Kinase | 1967 |
Effect of folinate on thymidine uptake by Pediococcus cerevisiae.
Topics: Aminopterin; Carbon Isotopes; Deoxyuridine; Floxuridine; Glucose; Hydrogen-Ion Concentration; Iodoacetates; Leucovorin; Methotrexate; Pediococcus; Temperature; Thymidine; Thymine; Tritium; Uracil | 1968 |
Fluorinated pyrimidines. XXXI. Mechanisms of inhibition of vaccinia virus replication in HeLa cells by pyrimidine nucleosides.
Topics: Culture Media; Cytarabine; Deoxyuridine; Floxuridine; HeLa Cells; Idoxuridine; Methods; Pyrimidines; Time Factors; Vaccinia virus; Virus Replication | 1969 |
An autoradiographic and immunofluorescent study of the infectious cycle of sheeppox virus in cell cultures exposed to 5-fluorodeoxyuridine.
Topics: Animals; Antigens; Autoradiography; Culture Techniques; Cytopathogenic Effect, Viral; Deoxyuridine; DNA, Viral; Floxuridine; Fluorescent Antibody Technique; Microscopy, Fluorescence; Poxviridae; Sheep; Sheep Diseases; Tritium; Viral Proteins; Virus Replication | 1968 |
Corriparta virus: properties and multiplication in experimentally-inoculated mosquitoes.
Topics: Animals; Arboviruses; Bile Acids and Salts; Chloroform; Chymotrypsin; Culex; Culture Techniques; Dactinomycin; Deoxyuridine; Ethyl Ethers; Floxuridine; Hemagglutination Inhibition Tests; Hemagglutination Tests; Hot Temperature; Hydrogen-Ion Concentration; Mice; Microscopy, Electron; Phospholipases; Reoviridae; RNA, Viral; Trypsin; Virus Cultivation | 1969 |
Molecular conformation of deoxyuridine.
Topics: Base Sequence; Bromodeoxyuridine; Chemical Phenomena; Chemistry; Deoxyuridine; Floxuridine; Idoxuridine; Models, Structural | 1971 |
Failure of alkylated HEp.2 cells to replicate newly synthesized DNA.
Topics: Alkanes; Alkylating Agents; Carbon Isotopes; Carcinoma; Cell Line; Centrifugation, Density Gradient; Chemical Precipitation; Culture Media; Culture Techniques; Deoxyuridine; DNA; DNA Repair; DNA Replication; Floxuridine; Humans; Hydroxyurea; Laryngeal Neoplasms; Methods; Sulfonic Acids; Thymidine; Tritium | 1971 |
Phase I and II studies of 2'-deoxy-5-(trifluoromethyl)-uridine (NSC-75520).
Topics: Blood Cell Count; Bone Marrow; Breast Neoplasms; Colonic Neoplasms; Deoxyuridine; Female; Floxuridine; Half-Life; Humans; Leukopenia; Rectal Neoplasms; Thrombocytopenia; Thymidine; Time Factors | 1971 |
Determinants of responsiveness to 5-fluorouridine in transplantable murine leukemias.
Topics: Animals; Antineoplastic Agents; Biodegradation, Environmental; Biological Transport; Cell Line; Cell Survival; Cells, Cultured; Deoxyuridine; DNA Replication; DNA, Neoplasm; Drug Resistance; Floxuridine; Fluorine; Fluorouracil; Leukemia, Experimental; Mice; Neoplasm Transplantation; Pentosyltransferases; Phosphotransferases; Uridine | 1971 |
Kinetic and photochemical studies of 3-N-methyl-5-iodo-2-'-deoxyuridine. Sensitization of ultraviolet inactivation of thymidine kinase by 3-N-methyl-5-iodo-2'-deoxyuridine and other halogenated analogs of thymidine.
Topics: Adenosine Triphosphate; Bromodeoxyuridine; Carbon Isotopes; Cytosine Nucleotides; Deoxyribonucleotides; Deoxyuridine; Escherichia coli; Floxuridine; Idoxuridine; Iodine; Kinetics; Magnesium; Methylation; Photochemistry; Photolysis; Radiation Effects; Spectrophotometry; Stimulation, Chemical; Thymidine; Thymidine Kinase; Thymine Nucleotides; Ultraviolet Rays | 1972 |
The role of uridine-cytidine kinase in the regulation of pyrimidine ribonucleotide synthesis in Tetrahymena pyriformis GL.
Topics: Adenosine Triphosphate; Animals; Carbon Isotopes; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Paper; Cytidine; Deoxyribonucleosides; Deoxyribonucleotides; Deoxyuridine; Enzyme Activation; Feedback; Floxuridine; Guanosine Triphosphate; Kinetics; Magnesium; Molecular Weight; Nucleotides; Phosphotransferases; Pyrimidine Nucleotides; Ribonucleotides; Tetrahymena pyriformis; Tritium; Uridine | 1971 |
Metabolism of pyrimidines and pyrimidine nucleosides by Salmonella typhimurium.
Topics: Aminohydrolases; Cytidine; Cytosine; Deoxyuridine; Floxuridine; Flucytosine; Fluorouracil; Genetics, Microbial; Genotype; Mutation; Nucleosides; Nucleotidyltransferases; Pentosyltransferases; Phosphotransferases; Pyrimidines; Salmonella typhimurium; Thymidine; Uracil; Uracil Nucleotides; Uridine | 1972 |
5-Fluorouracil and derivatives in cancer chemotherapy. II. Possible in vivo formation and stabilization of 5-fluoro-2'-deoxyuridine.
Topics: Biopharmaceutics; Biotransformation; Chromatography, Thin Layer; Deoxyuridine; Dialysis; Drug Stability; Floxuridine; Fluorouracil; Humans; Neoplasms; Spectrophotometry, Ultraviolet | 1972 |
Complex formation of uracil, 2'-deoxyuridine and their 5-halogenated derivatives.
Topics: Bromodeoxyuridine; Bromouracil; Chemical Phenomena; Chemistry; Copper; Deoxyuridine; Drug Stability; Floxuridine; Fluorouracil; Idoxuridine; Mathematics; Nickel; Potentiometry; Silver; Uracil | 1973 |
5-Fluorouracil and derivatives in cancer chemotherapy. 3. In vivo enhancement of antitumor activity of 5-fluorouracil (FU) and 5-fluoro-2'-deoxyuridine (FUDR).
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Chromatography, Thin Layer; Deoxycytidine; Deoxyuridine; Dialysis; Drug Synergism; Drug Therapy, Combination; Floxuridine; Fluorouracil; Leukemia L1210; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Neoplasms, Experimental; Transplantation, Homologous | 1973 |
Assay of 5-fluorodeoxyuridine 5'-monophosphate deoxyuridine 5'-monophosphate pools following 5-fluorouracil.
Topics: Animals; Cell Line; Clinical Enzyme Tests; Deoxyuridine; Depression, Chemical; DNA, Neoplasm; Floxuridine; Fluorouracil; Hydrogen-Ion Concentration; Lacticaseibacillus casei; Mice; Neoplasms, Experimental; Phosphates; Thymidylate Synthase | 1974 |
Properties of 5-bromodeoxyuridine-resistant lines of higher plant cells in liquid culture.
Topics: Aminopterin; Biological Transport; Bromodeoxyuridine; Carbon Radioisotopes; Cell Division; Cell Line; Centrifugation, Density Gradient; Culture Media; Deoxyuridine; DNA; Drug Resistance; Floxuridine; Glycine; Glycine max; Hypoxanthines; Nitrosoguanidines; Plants; Protoplasts; Thymidine; Thymidine Kinase; Time Factors; Tritium | 1974 |
The influence of 5-halo substituents on the thermal depyrimidination of the glycosidic bond in 2'-deoxyuridines.
Topics: Bromodeoxyuridine; Calorimetry; Deoxyuridine; Floxuridine; Guanosine; Iodine; Molecular Conformation; Temperature; Thermodynamics; Thymidine; Thymine; Uracil | 1974 |
Clinical evaluation of 5-bromo-5-fluoro-6-methoxy-dihydro-2'-deoxyuridine.
Topics: Adenocarcinoma; Adult; Aged; Animals; Bromodeoxyuridine; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; Colonic Neoplasms; Deoxyuridine; Dogs; Female; Floxuridine; Gallbladder Neoplasms; Gastrointestinal Neoplasms; Humans; Ileocecal Valve; Intestinal Neoplasms; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Pancreatic Neoplasms; Rectal Neoplasms; Sarcoma; Stomach Neoplasms | 1967 |
Sensitivity of herpes simplex virus, vaccinia virus, and adenoviruses to deoxyribonucleic acid inhibitors and thiosemicarbazones in a plaque suppression test.
Topics: Adenoviridae; Antiviral Agents; Bromodeoxyuridine; Cytarabine; Cytopathogenic Effect, Viral; Deoxyuridine; Floxuridine; HeLa Cells; Idoxuridine; Simplexvirus; Thiosemicarbazones; Vaccinia virus | 1968 |
Comparative studies of fluorinated pyrimidines with various cell lines.
Topics: Animals; Carcinoma, Hepatocellular; Culture Techniques; Deoxyuridine; Depression, Chemical; DNA, Neoplasm; Floxuridine; HeLa Cells; Leukemia, Experimental; Liver Neoplasms; Neoplasms, Experimental; Nucleosides; Phosphotransferases; Pyrimidines; RNA, Neoplasm; Thymidine; Thymidine Kinase; Uridine | 1968 |
Tetrahydrodeoxyuridylate: a potent inhibitor of deoxycytidylate deaminase.
Topics: Aminohydrolases; Animals; Carbon Isotopes; Chick Embryo; Chromatography, Ion Exchange; Chromatography, Paper; Cytosine Nucleotides; Deoxyribonucleases; Deoxyribonucleosides; Deoxyribonucleotides; Deoxyuridine; DNA; Electrophoresis; Floxuridine; Kinetics; Metabolism; Pancreas; Phosphoric Monoester Hydrolases; Ribonucleosides; Thymine Nucleotides; Uracil Nucleotides; Uridine; Venoms | 1971 |
Effects of inhibitors of DNA synthesis on haemagglutinin and infectious SV 15 virus formation in green monkey kidney cells.
Topics: Adenoviridae; Animals; Culture Techniques; Cytopathogenic Effect, Viral; Deoxyuridine; DNA, Viral; Floxuridine; Haplorhini; Hemagglutination Inhibition Tests; Hemagglutinins, Viral; Kidney; Microscopy, Electron; Uracil; Virus Cultivation; Virus Replication | 1969 |
Modulation of 1-beta-D-arabinofuranosylcytosine metabolism and cytotoxicity in L1210 cells by fluoropyrimidine pretreatment.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Cell Line; Cell Survival; Clone Cells; Cytarabine; Deoxyribonucleotides; Deoxyuridine; Drug Interactions; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Leukemia L1210; Mice; Uridine | 1982 |
Interaction of 2'-halogeno-2'-deoxyuridines with the human erythrocyte nucleoside transport mechanism.
Topics: Binding, Competitive; Biological Transport, Active; Bromodeoxyuridine; Deoxyuridine; Erythrocyte Membrane; Erythrocytes; Floxuridine; Humans; Idoxuridine; Kinetics; Nucleosides; Structure-Activity Relationship; Thymidine | 1983 |
Rate-limiting steps in the interactions of fluoropyrimidines and methotrexate.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; Deoxyuridine; DNA, Neoplasm; Drug Interactions; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Methotrexate; Mice; Neoplasm Proteins; RNA, Neoplasm; Thymidine Monophosphate | 1984 |
Biochemical mechanisms in the Killmann experiment: critique of the deoxyuridine suppression test.
Topics: Deoxyribonucleosides; Deoxyuridine; DNA; Floxuridine; Humans; In Vitro Techniques; Lymphocyte Activation; Lymphocytes; Methotrexate; Phytohemagglutinins; Thymidine; Thymidine Kinase; Thymine Nucleotides | 1980 |
Fluorinated pyrimidine nucleosides. 4. Synthesis and antitumor testing of a series of 2',5'-dideoxy- and 2',3',5'-trideoxynucleosides of 5-fluorouracil.
Topics: Animals; Antineoplastic Agents; Deoxyuridine; Floxuridine; Fluorouracil; Mice; Sarcoma 180; Tegafur | 1980 |
fluoropyrimidine-induced antagonism to free and tightly bound methotrexate: suppression of [14C] formate incorporation into RNA and protein.
Topics: Animals; Carbon Radioisotopes; Carcinoma, Ehrlich Tumor; Deoxyuridine; DNA, Neoplasm; Floxuridine; Formates; Methotrexate; Mice; Neoplasm Proteins; RNA, Neoplasm | 1980 |
Polyglutamyl derivatives of tetrahydrofolate as substrates for Lactobacillus casei thymidylate synthase.
Topics: Deoxyuridine; Floxuridine; Fluorodeoxyuridylate; Iodoacetamide; Kinetics; Lacticaseibacillus casei; Methyltransferases; Sodium Chloride; Substrate Specificity; Tetrahydrofolates; Thymidylate Synthase | 1981 |
Recognition of 2'-hydroxyl groups by Escherichia coli ribonuclease HI.
Topics: Base Sequence; Deoxyuridine; Escherichia coli; Floxuridine; Hydrogen Bonding; Hydroxyl Radical; Kinetics; Models, Molecular; Molecular Sequence Data; Oligonucleotides; Protein Structure, Tertiary; Ribonuclease H; Ribonucleosides | 1995 |
Augmentation of 5-fluoro-2'-deoxyuridine cytotoxicity by 5-phenethyl-2'-deoxyuridine in human gastric cancer cells in culture.
Topics: Carbon Radioisotopes; Deoxyuridine; DNA, Neoplasm; Drug Synergism; Floxuridine; Humans; Nucleosides; Nucleotides; RNA, Neoplasm; Stomach Neoplasms; Thymidine; Tritium; Tumor Cells, Cultured; Uridine | 1994 |
Synthesis of 2'-deoxyuridine and 5-fluoro-2'-deoxyuridine derivatives and evaluation in antibody targeting studies.
Topics: Antibodies, Monoclonal; Antibodies, Neoplasm; Antimetabolites, Antineoplastic; Deoxyuridine; Drug Screening Assays, Antitumor; Floxuridine; Humans; Serum Albumin; Tumor Cells, Cultured | 1993 |
Synthesis and biological activity of O-alkyl-3-N-aminoacyloxymethyl-5-fluoro-2'-deoxyuridine derivatives.
Topics: Animals; Antimetabolites, Antineoplastic; Chemical Phenomena; Chemistry, Physical; Deoxyuridine; Female; Floxuridine; Mice; Mice, Inbred ICR; Sarcoma 180 | 1996 |
Ineffectiveness of 5-fluoro-2'-deoxyuridine in man after failure of 5-fluorouracil.
Topics: Deoxyuridine; Floxuridine; Fluorouracil; Folic Acid; Humans | 1963 |
STUDIES ON THE ADJUVANT ACTION OF BACTERIAL ENDOTOXINS ON ANTIBODY FORMATION. V. THE INFLUENCE OF ENDOTOXIN AND 5-FLUORO-2-DEOXYURIDINE ON THE PRIMARY ANTIBODY RESPONSE OF THE BALB MOUSE TO A PURIFIED PROTEIN ANTIGEN.
Topics: Adjuvants, Immunologic; Animals; Antibody Formation; Antigen-Antibody Reactions; Antigens; Cattle; Deoxyuridine; Endotoxins; Floxuridine; Mice; Research; Serratia marcescens | 1963 |
ACCUMULATION OF ACID-SOLUBLE NUCLEIC ACID PRECURSORS IN HELA CELLS INHIBITED BY 5-FLUORO-2'-DEOXYURIDINE.
Topics: Deoxyuridine; DNA; Floxuridine; HeLa Cells; Humans; Nucleic Acid Precursors; Nucleosides; Pharmacology; Research; RNA; Thymidine; Tissue Culture Techniques | 1963 |
FLUORINATED PYRIMIDINES. XX. INHIBITION OF THE NUCLEOSIDE PHOSPHORYLASE CLEAVAGE OF 5-FLUORO-2'-DEOXYURIDINE BY 5-TRIFLUOROMETHYL-2'-DEOXYURIDINE.
Topics: Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Deoxyuridine; Enzyme Inhibitors; Floxuridine; Fluorine; Glucosyltransferases; Nucleosides; Pentosyltransferases; Pyrimidines; Research; Tissue Extracts; Trifluridine | 1963 |
[HALOGENATED DEOXYURIDINE AS VIRUS INHIBITORS].
Topics: Animals; Antiviral Agents; Bromine; Chick Embryo; Chlorine; Deoxyuridine; Floxuridine; Halogenation; Idoxuridine; Nucleosides; Research; Vaccinia virus | 1963 |
STUDIES ON THE EFFECT OF 5-FLUORO-2'-DEOXYURIDINE ON POLYAMA T FORMATION IN MOUSE EMBRYO CELLS.
Topics: Animals; Antigens; Deoxyuridine; DNA; DNA, Viral; Electrons; Embryo, Mammalian; Embryo, Nonmammalian; Floxuridine; Mice; Microscopy; Microscopy, Electron; Neoplasms; Neoplasms, Experimental; Polyomavirus; Research; Tissue Culture Techniques; Viral Proteins; Virus Cultivation | 1964 |
THE EFFECT OF NATURAL AND UNNNATURAL PYRIMIDINES AND PYRIMIDINE NUCLEOSIDES ON THE PHOSPHOROLYSIS OF 5-IODODEOXYURIDINE BY MOUSE LIVER EXTRACT.
Topics: Animals; Chromatography; Deoxyuridine; Floxuridine; Fluorouracil; Idoxuridine; Iodine Isotopes; Liver; Liver Extracts; Metabolism; Mice; Nucleosides; Pharmacology; Phosphotransferases; Pyrimidine Nucleosides; Pyrimidines; Research; Thymidine; Thymine; Uracil | 1964 |
TYPE OF ANTIBODY ELEVATED BY 5-FLUORO-2-DEOXYURIDINE AND ENDOTOXIN DURING THE PRIMARY RESPONSE OF THE MOUSE.
Topics: Animals; Antibodies; Antibody Formation; Chromatography; Deoxyuridine; Endotoxins; Floxuridine; gamma-Globulins; Hemagglutination; Immunoglobulins; Infections; Mice; Pharmacology; Research; Serratia marcescens; Sulfhydryl Compounds; Toxicology | 1964 |
THE EFFECT OF 5-FLUORO-2'-DEOXYURIDINE ON SYNCHRONOUS MITOSIS IN PHYSARUM POLYCEPHALUM.
Topics: Cell Division; Deoxyuridine; DNA; Floxuridine; Metabolism; Mitosis; Pharmacology; Physarum polycephalum; Plasmodium; Research; RNA; Thymidine; Uridine | 1964 |
PROPERTIES OF DEOXYTHYMIDINE KINASE PARTIALLY PURIFIED FROM NONINFECTED MOUSE FIBROBLAST CELLS.
Topics: Animals; Bromodeoxyuridine; Cell Division; Deoxyuridine; Enzyme Inhibitors; Fibroblasts; Floxuridine; Immune Sera; Kinetics; Mice; Nucleotides; Phosphotransferases; Rabbits; Research; Simplexvirus; Thymidine; Thymidine Kinase; Tritium; Uridine; Vaccinia virus | 1965 |
EFFECT OF 5-FLUORO-2'-DEOXYURIDINE ON THE SYNTHESIS OF VACCINIA VIRUS.
Topics: Antigens; Autoradiography; Deoxyuridine; DNA; DNA, Viral; Floxuridine; Fluorescent Antibody Technique; HeLa Cells; Humans; Nucleosides; Nucleotides; Pharmacology; Research; Tissue Culture Techniques; Uridine; Vaccinia virus; Virus Cultivation | 1965 |
The potentiation by 5-iodo-2'-deoxyuridine (IUDR) of the tumor-inhibitory activity of 5-fluoro-2'-deoxyuridine (FUDR).
Topics: Antineoplastic Agents; Deoxyuridine; Floxuridine; Humans; Idoxuridine; Neoplasms; Nucleosides; Nucleotides | 1960 |
Studies on the feasibility of adjuvant chemotherapy with 5-fluorouracil (FU) and 5-fluoro-2'-deoxyuridine (FUDR) in the immediate postoperative period.
Topics: Antineoplastic Agents; Chemotherapy, Adjuvant; Deoxyuridine; Floxuridine; Fluorouracil; Humans; Postoperative Period; Pyrimidines; Uracil | 1962 |
[Antisense oligonucleotides with antitumor activity].
Topics: Adenocarcinoma; Antineoplastic Agents; Cell Line, Tumor; Colonic Neoplasms; Deoxyuridine; Fibrosarcoma; Floxuridine; HT29 Cells; Humans; Inhibitory Concentration 50; Matrix Metalloproteinase Inhibitors; Oligonucleotides, Antisense; Prodrugs; Telomerase | 2004 |
Effect of fluoropyrimidines on the growth of Ureaplasma urealyticum.
Topics: Antimetabolites, Antineoplastic; Cell Proliferation; Deoxyuridine; DNA; Dose-Response Relationship, Drug; Floxuridine; Pyrimidines; Thymidine; Time Factors; Ureaplasma; Ureaplasma urealyticum | 2004 |
Charge transfer excited-state dynamics in DNA duplexes substituted with an ethynylpyrenyldeoxyuridine electron source and a fluorodeoxyuridine electron trap.
Topics: Base Sequence; Deoxyuridine; DNA; Electrons; Floxuridine; Kinetics; Molecular Structure; Transition Temperature | 2005 |
Antiviral activities and phosphorylation of 5-halo-2'-deoxyuridines and N-methanocarbathymidine in cells infected with vaccinia virus.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Cell Line, Tumor; Chlorocebus aethiops; Deoxyuridine; Floxuridine; Humans; Idoxuridine; Mice; Phosphorylation; Thymidine; Thymidine Kinase; Vaccinia; Vaccinia virus; Vero Cells; Viral Plaque Assay | 2008 |
Combinatorial pharmacologic effects of gemcitabine and its metabolite dFdU.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Combinatorial Chemistry Techniques; Deoxycytidine; Deoxyuridine; Embryo, Nonmammalian; Embryonic Development; Floxuridine; Gemcitabine; Humans; Tumor Stem Cell Assay; Zebrafish | 2011 |
High sensitive assay employing column switching chromatography to enable simultaneous quantification of an amide prodrug of gemcitabine (LY2334737), gemcitabine, and its metabolite dFdU in human plasma by LC-MS/MS.
Topics: Antimetabolites, Antineoplastic; Chromatography, Liquid; Deoxycytidine; Deoxyuridine; Floxuridine; Gemcitabine; Humans; Prodrugs; Sensitivity and Specificity; Tandem Mass Spectrometry | 2013 |
Adjusting the neuron to astrocyte ratio with cytostatics in hippocampal cell cultures from postnatal rats: A comparison of cytarabino furanoside (AraC) and 5-fluoro-2'-deoxyuridine (FUdR).
Topics: Animals; Astrocytes; Cell Culture Techniques; Cells, Cultured; Cytostatic Agents; Deoxyuridine; Floxuridine; Hippocampus; Neurons; Rats | 2022 |
Fluorinated pyrimidines. VI. Effects of 5-fluorouridine and 5-fluoro-2'-deoxyuridine on transplanted tumors.
Topics: Animals; Antineoplastic Agents; Deoxyuridine; Neoplasms, Experimental; Pyrimidines; Uridine | 1958 |
Growth inhibition of a human tumor cell strain by 5-fluorouracil, 5-fluorouridine, and 5-fluoro-2'-deoxyuridine; reversal studies.
Topics: Antineoplastic Agents; Deoxyuridine; Fluorouracil; Humans; Nucleosides; Nucleotides; Uridine | 1958 |
Growth inhibition of a human tumor cell strain by 5-fluoro-2-deoxyuridine: time parameters for subsequent reversal by thymidine.
Topics: Animals; Antineoplastic Agents; Deoxyuridine; Humans; Neoplasms, Experimental; Nucleosides; Nucleotides; Thymidine | 1959 |
Clinical studies with 5-fluoro-2'-deoxyuridine.
Topics: Antineoplastic Agents; Biomedical Research; Deoxyuridine; Nucleosides; Nucleotides | 1960 |
The clinical effects of the continuous administration of fluorinated pyrimidines (5-fluorouracil and 5-fluoro-2'-deoxyuridine).
Topics: Deoxyuridine; Fluorouracil; Halogenation; Neoplasms; Nucleosides; Nucleotides; Pyrimidines | 1960 |
The clinical evaluation of 5-fluorouracil and 5-fluoro-2'-deoxyuridine in solid tumors in adults: a progress report.
Topics: Antineoplastic Agents; Deoxyuridine; Fluorouracil; Neoplasms; Nucleosides; Nucleotides; Research Report; Uracil | 1960 |
A preliminary comparison of 5-fluoro-2'-deoxyuridine administered by rapid daily intravenous injections and by slow continuous infusion.
Topics: Antineoplastic Agents; Deoxyuridine; Injections, Intravenous; Nucleosides; Nucleotides | 1962 |
Comparison of 5-fluorouracil and 5-fluoro-2'-deoxyuridine in the treatment of far-advanced breast and colon lesions.
Topics: Antineoplastic Agents; Breast Neoplasms; Colonic Neoplasms; Deoxyuridine; Fluorouracil; Humans; Nucleosides; Nucleotides; Uracil | 1962 |
Effects of uracil and thymidine on the development of resistance to 5-fluorouracil in Pediococcus cerevisiae.
Topics: Deoxyuridine; Fluorouracil; Pediococcus; Thymidine; Uracil | 1963 |
The clinical evaluation of 5-fluoro-2'-deoxyuridine in acute leukemia in children.
Topics: Child; Deoxyuridine; Infant; Leukemia; Neoplasms; Nucleosides; Nucleotides | 1960 |
Clinical experience with 5-fluoro-2'-deoxyuridine.
Topics: Antineoplastic Agents; Deoxyuridine; Nucleosides; Nucleotides | 1960 |
Clinical evaluation of the pyrimidine nucleosides 5-fluoro-2'-deoxyuridine and 5-iodo-2'-deoxyuridine.
Topics: Antineoplastic Agents; Deoxyuridine; Idoxuridine; Nucleosides; Nucleotides; Pyrimidine Nucleosides | 1962 |
A kinetic study of the action of 5-fluoro-2'-deoxyuridine on synthetic processes in mammalian cells.
Topics: Animals; Deoxyuridine; Kinetics; Nucleosides; Nucleotides; Research Design; Tissue Culture Techniques | 1962 |
Synthesis and study of cyclic pronucleotides of 5-fluoro-2'-deoxyuridine.
Topics: Cell Line; Cell Proliferation; Cyclization; Deoxyuridine; Humans; Models, Molecular; Molecular Structure; Nucleotides; Stereoisomerism | 2012 |
Sensitivity of gastric adenocarcinoma and normal cell lines against combined or conjugated antimetabolites.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Line; Cell Line, Tumor; Chromatography, High Pressure Liquid; Cisplatin; Cytidine; Cytostatic Agents; Deoxyuridine; Drug Resistance, Neoplasm; Drug Synergism; Epirubicin; Fibroblasts; Humans; Molecular Structure; Oligonucleotides; Prodrugs; Skin; Stomach; Stomach Neoplasms; Tumor Stem Cell Assay | 2013 |
Development of modified siRNA molecules incorporating 5-fluoro-2'-deoxyuridine residues to enhance cytotoxicity.
Topics: Apoptosis; Cell Line, Tumor; Deoxyuridine; Humans; RNA, Small Interfering; Thymidylate Synthase; Transfection | 2013 |
Breaking the invulnerability of cancer stem cells: two-step strategy to kill the stem-like cell subpopulation of multiple myeloma.
Topics: Apoptosis; Cell Line, Tumor; Cell Lineage; Deoxyuridine; DNA Damage; Enzyme Inhibitors; Humans; Multiple Myeloma; Neoplasm Recurrence, Local; Neoplastic Stem Cells; Thymidylate Synthase | 2014 |
Effects of 5'-fluoro-2-deoxyuridine on mitochondrial biology in Caenorhabditis elegans.
Topics: Adenosine Triphosphate; Aging; Animals; Caenorhabditis elegans; Deoxyuridine; DNA Damage; DNA Replication; DNA, Mitochondrial; Energy Metabolism; Gene Dosage; Genotype; Half-Life; Mitochondria; Phenotype; Time Factors | 2014 |
Interaction of the 5-fluorouracil analog 5-fluoro-2'-deoxyuridine with 'N' and 'B' isoforms of human serum albumin: a spectroscopic and calorimetric study.
Topics: Binding Sites; Calorimetry; Deoxyuridine; Humans; Hydrogen-Ion Concentration; Molecular Docking Simulation; Protein Isoforms; Serum Albumin; Spectrometry, Fluorescence; Substrate Specificity; Thermodynamics | 2014 |
An aptamer intrinsically comprising 5-fluoro-2'-deoxyuridine for targeted chemotherapy.
Topics: Animals; Apoptosis; Aptamers, Nucleotide; Cell Cycle Checkpoints; Cell Line, Tumor; Deoxyuridine; Drug Carriers; G-Quadruplexes; Mice; Neoplasms; Prodrugs; Protein Binding; Receptors, Interleukin-6 | 2014 |
Trifluridine Induces p53-Dependent Sustained G2 Phase Arrest with Its Massive Misincorporation into DNA and Few DNA Strand Breaks.
Topics: Antineoplastic Agents; CDC2 Protein Kinase; Cell Line, Tumor; Cyclin B1; Deoxyuridine; DNA Breaks; DNA Replication; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Gene Knockout Techniques; Humans; Inhibitory Concentration 50; Oncogene Protein p21(ras); Proteasome Endopeptidase Complex; Transcription, Genetic; Trifluridine; Tumor Suppressor Protein p53 | 2015 |
ALPPL2 Aptamer-Mediated Targeted Delivery of 5-Fluoro-2'-Deoxyuridine to Pancreatic Cancer.
Topics: Alkaline Phosphatase; Antineoplastic Agents; Aptamers, Nucleotide; Base Sequence; Biomarkers, Tumor; Caveolae; Cell Line, Tumor; Cell Proliferation; Deoxyuridine; Drug Carriers; Dynamins; Endocytosis; Gene Expression; GPI-Linked Proteins; Humans; Ligands; Molecular Sequence Data; Molecular Targeted Therapy; Pancreas; SELEX Aptamer Technique | 2015 |
The influence of p53 status on the cytotoxicity of fluorinated pyrimidine L-nucleosides.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Deoxyuridine; Fluorouracil; Inhibitory Concentration 50; Mice; Molecular Structure; Pyrimidine Nucleosides; Tumor Suppressor Protein p53 | 2015 |
Exploring the intracellular pharmacokinetics of the 5-fluorouracil nucleotides during capecitabine treatment.
Topics: Antimetabolites, Antineoplastic; Area Under Curve; Capecitabine; Chromatography, Liquid; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Deoxyuracil Nucleotides; Deoxyuridine; Fluorouracil; Humans; Leukocytes, Mononuclear; Neoplasms; Tandem Mass Spectrometry; Uridine Triphosphate | 2016 |
New 3'-O-aromatic acyl-5-fluoro-2'-deoxyuridine derivatives as potential anticancer agents.
Topics: Antineoplastic Agents; Cell Proliferation; Cell Survival; Cells, Cultured; Deoxyuridine; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Prodrugs; Structure-Activity Relationship | 2016 |
Discovery of an Orally Active and Liver-Targeted Prodrug of 5-Fluoro-2'-Deoxyuridine for the Treatment of Hepatocellular Carcinoma.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Area Under Curve; Carcinoma, Hepatocellular; Deoxyuridine; Drug Discovery; Liver; Liver Neoplasms, Experimental; Mice; Prodrugs; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2016 |
MicroRNA-351 Regulates Two-Types of Cell Death, Necrosis and Apoptosis, Induced by 5-fluoro-2'-deoxyuridine.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Death; Cell Line, Tumor; Deoxyuridine; Gene Expression Profiling; Lamin Type B; Mice; MicroRNAs; Molecular Mimicry; Necrosis; RNA, Messenger; Transfection; Up-Regulation | 2016 |
Synthesis and anticancer activity of some 5-fluoro-2'-deoxyuridine phosphoramidates.
Topics: Amides; Antineoplastic Agents; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deoxyuridine; Humans; Neoplasms; Phosphoric Acids | 2016 |
LC-MS/MS assay for the quantitation of FdCyd and its metabolites FdUrd and FU in human plasma.
Topics: Biological Assay; Chromatography, Liquid; Deoxyuridine; Fluorouracil; Humans; Plasma; Tandem Mass Spectrometry; Tetrahydrouridine | 2016 |
FUdR extends the lifespan of the short-lived AP endonuclease mutant in Caenorhabditis elegans in a fertility-dependent manner.
Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Cycle Proteins; Deoxyuridine; DNA Damage; DNA-(Apurinic or Apyrimidinic Site) Lyase; Female; Fertility; Gene Expression Regulation; Male; Mutation; Oocytes; Receptors, Notch; Spermatozoa | 2017 |
Bacterial Metabolism Affects the C. elegans Response to Cancer Chemotherapeutics.
Topics: Animals; Antineoplastic Agents; Caenorhabditis elegans; Camptothecin; Colorectal Neoplasms; Comamonas; Deoxyuridine; Diet; Escherichia coli; Fluorouracil; Gastrointestinal Microbiome; Humans; Models, Animal; Pyrimidine Nucleosides | 2017 |
All-atom MD indicates ion-dependent behavior of therapeutic DNA polymer.
Topics: Calcium; Cluster Analysis; Deoxyuridine; DNA; Hydrogen Bonding; Ions; Markov Chains; Molecular Dynamics Simulation; Nucleic Acid Conformation; Principal Component Analysis; Zinc | 2017 |
DNA-based nanoscaffolds as vehicles for 5-fluoro-2'-deoxyuridine oligomers in colorectal cancer therapy.
Topics: Cell Line, Tumor; Cholesterol; Colorectal Neoplasms; Deoxyuridine; DNA; Drug Resistance, Neoplasm; Fluorouracil; Humans; Nanostructures | 2018 |
Studies directed toward the asialoglycoprotein receptor mediated delivery of 5-fluoro-2'-deoxyuridine for hepatocellular carcinoma.
Topics: Antineoplastic Agents; Asialoglycoprotein Receptor; Carcinoma, Hepatocellular; Deoxyuridine; Drug Delivery Systems; Hep G2 Cells; Humans; Liver Neoplasms; Phosphorylation; Prodrugs | 2018 |
Reactivation of RNA metabolism underlies somatic restoration after adult reproductive diapause in
Topics: Animals; Caenorhabditis elegans; Deoxyuridine; Diapause; DNA, Mitochondrial; Germ Cells; Longevity; Reproduction; RNA; Stem Cells | 2018 |
Studies on interaction potency model based on drug synergy and therapeutic potential of triple stimuli-responsive delivery of doxorubicin and 5-fluoro-2-deoxyuridine against lymphoma using disulfide-bridged cysteine over mesoporous silica nanoparticles.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cysteine; Deoxyuridine; Disulfides; Doxorubicin; Drug Screening Assays, Antitumor; Humans; Lymphoma; Mice; Nanoparticles; Neoplasms, Experimental; Particle Size; Porosity; Silicon Dioxide; Surface Properties | 2020 |
Infertility induced by auxin in PX627
Topics: Aging; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Deoxyuridine; DNA, Mitochondrial; Fertility; Indoleacetic Acids; Longevity; Mitochondria; Models, Animal; Proteolysis | 2020 |
A simple and efficient sequential electrokinetic and hydrodynamic injections in micellar electrokinetic chromatography method for quantification of anticancer drug 5-fluorouracil and its metabolite in human plasma.
Topics: Antineoplastic Agents; Chromatography, Micellar Electrokinetic Capillary; Deoxyuridine; Fluorouracil; Humans | 2021 |
Parallel G-quadruplex Structures Increase Cellular Uptake and Cytotoxicity of 5-Fluoro-2'-deoxyuridine Oligomers in 5-Fluorouracil Resistant Cells.
Topics: Cytotoxins; Deoxyuridine; Drug Resistance, Neoplasm; Fluorouracil; G-Quadruplexes; HeLa Cells; HT29 Cells; Humans; Neoplasms | 2021 |
Targeting PD-1 in CD8
Topics: Animals; Apoptosis; Bilirubin; Biomimetic Materials; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Deoxyuridine; Disease Models, Animal; Down-Regulation; Drug Carriers; Gene Expression Regulation, Neoplastic; Humans; Lymphoma; Mice; Programmed Cell Death 1 Receptor; Serum Albumin, Bovine | 2021 |
Novel ProTide prodrugs of 5-fluoro-2'-deoxyuridine for the treatment of liver cancer.
Topics: Deoxyuridine; Fluorouracil; Humans; Liver Neoplasms; Prodrugs | 2023 |