flosequinoxan has been researched along with flosequinan in 10 studies
| Studies (flosequinoxan) | Trials (flosequinoxan) | Recent Studies (post-2010) (flosequinoxan) | Studies (flosequinan) | Trials (flosequinan) | Recent Studies (post-2010) (flosequinan) |
|---|---|---|---|---|---|
| 11 | 2 | 0 | 139 | 44 | 10 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 9 (90.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Frodsham, G; Jones, RB | 1 |
| Hague, NL; Hunneyball, IM; Loh, E; Morgan, JP; Perreault, CL; Sim, MF | 1 |
| Fujita, S; Hosoki, E; Ikezono, K; Ishikawa, M; Kusunoki, A; Shintani, S; Toba, Y; Umezato, M | 1 |
| Crampton, EL; Hind, ID; Wynne, RD | 1 |
| Britton, LW; Ferraris, VA; Kiser, LM; Sim, MF; Wallace, AM; Weishaar, RE | 1 |
| Janssen, MC; Reyenga, J; Smits, P; Thien, T | 1 |
| Kelso, EJ; McDermott, BJ; Silke, B | 1 |
| Hind, ID; Hinson, JL; Weidler, DJ | 1 |
| Britton, LW; Ferraris, VA; Kirker, ML; Sim, MF; Wallace, AM; Weishaar, RE | 1 |
| Bartels, GL; Kruijssen, DA; Look, MP; Remme, WJ | 1 |
2 trial(s) available for flosequinoxan and flosequinan
| Article | Year |
|---|---|
The pharmacokinetics and haemodynamics of BTS 49 465 and its major metabolite in healthy volunteers.
Topics: Administration, Oral; Adult; Blood Pressure; Diuresis; Double-Blind Method; Heart Rate; Hemodynamics; Humans; Kinetics; Male; Quinolines; Quinolones; Random Allocation; Renin; Saliva; Vasodilator Agents | 1985 |
Pharmacokinetics, safety, and tolerability of flosequinan in patients with hepatic dysfunction.
Topics: Adult; Biotransformation; Chromatography, High Pressure Liquid; Female; Humans; Liver Diseases; Male; Middle Aged; Quinolines; Quinolones; Spectrophotometry, Ultraviolet | 1994 |
8 other study(ies) available for flosequinoxan and flosequinan
| Article | Year |
|---|---|
Effect of flosequinan upon isoenzymes of phosphodiesterase from guinea-pig cardiac and vascular smooth muscle.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Guinea Pigs; Humans; Isoenzymes; Muscle, Smooth; Muscle, Smooth, Vascular; Myocardium; Phosphodiesterase Inhibitors; Quinolines; Quinolones; Vasodilator Agents | 1992 |
Differential inotropic effects of flosequinan in ventricular muscle from normal ferrets versus patients with end-stage heart failure.
Topics: Animals; Calcium; Colforsin; Dose-Response Relationship, Drug; Ferrets; Heart Failure; Heart Ventricles; Humans; In Vitro Techniques; Male; Milrinone; Myocardial Contraction; Pyridones; Quinolines; Quinolones; Stimulation, Chemical; Vasodilator Agents | 1992 |
General pharmacological properties of the main metabolite of flosequinan.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Autonomic Nervous System; Blood Coagulation; Cats; Central Nervous System; Digestive System; Dogs; Female; Guinea Pigs; In Vitro Techniques; Irritants; Male; Mice; Mice, Inbred ICR; Peripheral Nerves; Pregnancy; Quinolines; Quinolones; Rabbits; Rats; Rats, Wistar; Urodynamics | 1992 |
Assessment of flosequinan's direct effect on human arterial, venous, and cardiac muscle: comparison with other classes of agents used to treat heart failure.
Topics: Captopril; Diltiazem; Heart Failure; Humans; In Vitro Techniques; Milrinone; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Ouabain; Pyridones; Quinolines; Quinolones; Vasodilator Agents | 1994 |
Acute effects of flosequinan (BTS 49465) in untreated moderate to severe hypertension.
Topics: Administration, Oral; Adult; Aldosterone; Epinephrine; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Norepinephrine; Quinolines; Quinolones; Renin; Vasodilator Agents | 1995 |
Actions of the novel vasodilator, flosequinan, in isolated ventricular cardiomyocytes.
Topics: Adenylyl Cyclases; Animals; Heart; Heart Atria; Heart Rate; Heart Ventricles; Imidazoles; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Papillary Muscles; Phosphodiesterase Inhibitors; Pyrrolidinones; Quinolines; Quinolones; Rabbits; Rats; Rats, Sprague-Dawley; Rolipram; Stimulation, Chemical; Vasodilator Agents | 1995 |
Relationship between inotropic activity and phosphodiesterase inhibition for flosequinan and milrinone.
Topics: Humans; In Vitro Techniques; Milrinone; Myocardial Contraction; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridones; Quinolines; Quinolones; Vasodilation | 1993 |
Long-term vasodilator treatment with flosequinan does not lead to hemodynamic tolerance or neurohormonal activation in severe heart failure.
Topics: Aged; Female; Heart Failure; Hemodynamics; Humans; Male; Middle Aged; Neurotransmitter Agents; Quinolines; Quinolones; Vasodilator Agents | 1995 |