flocoumafen has been researched along with 4-hydroxycoumarin* in 1 studies
1 other study(ies) available for flocoumafen and 4-hydroxycoumarin
| Article | Year |
|---|---|
Total synthesis of flocoumafen via knoevenagel condensation and intramolecular ring cyclization: general access to natural products.
The total synthesis and structure determination of cis- and trans-flocoumafen was described. The key synthetic steps involve Knoevenagel condensation with p-methoxybenzaldehyde, in situ decarboxylation and intramolecular ring cyclization to construct the tetralone skeleton. Stereospecific reduction of the O-alkylated ketone 13 afforded good yield of precusor alcohol 5. Final coupling of alcohol 5 with 4-hydroxy-coumarin yielded flocoumafen (1). Separation and structure determination of cis- and trans-flocoumafen through 2D NMR analyses-assisted computer simulation techniques for the evaluation of anticoagulant activities are reported for the first time. This method is useful for generating the core tetralone skeleton of 4-hydroxycoumarin derivatives and provides a generalized access to various warfarin type anticoagulants. Topics: 4-Hydroxycoumarins; Alkylation; Anticoagulants; Benzaldehydes; Biological Products; Cyclization; Decarboxylation | 2012 |